CN102106461B - Enveloping acidifier for feed and preparation method thereof - Google Patents
Enveloping acidifier for feed and preparation method thereof Download PDFInfo
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- CN102106461B CN102106461B CN2010106224173A CN201010622417A CN102106461B CN 102106461 B CN102106461 B CN 102106461B CN 2010106224173 A CN2010106224173 A CN 2010106224173A CN 201010622417 A CN201010622417 A CN 201010622417A CN 102106461 B CN102106461 B CN 102106461B
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Abstract
The invention relates to enveloping acidifier and the preparation method thereof. The enveloping acidifier comprises acidifier solid microparticles and an enveloping layer on the surface of the acidifier solid microparticles, wherein the enveloping layer comprises an ethyecellulose (EC) and hydroxypropyl methyl cellulose (HPMC) composite layer and an enteric-coated polyacrylic resin layer. In the invention, sustained-release coating material with good film forming property and the coating process are adopted, so that excessive enveloping material consumption is avoided, the weight of the acidifier solid microparticles is increased slightly, the large total effective acid of the acidifier is kept, and the acidifier has good sustained-release effect.
Description
Technical field
The present invention relates to field of feed additive technology, specifically, relate to a kind of feed with being coated with acidulant and preparation method thereof.
Background technology
Acidulant is a kind of common animal feed additive, can reduce feed is sour power, suppress in feed and the growth of harmful bacteria in animal alimentary canal, and keep microbiotic balance in the animal animal alimentary canal, improve the digestibility of feed nutrition material, reduce the particularly diarrhoea of young animal of animal, and improve the immunity of animal body.Improve the growth performance of animal.
At present common acidulant is take compound acidulant as main, and its main component is various organic acids such as lactic acid, citric acid, fumaric acid, propionic acid, malic acid, sorbic acid, formic acid etc. with the inorganic acid such as phosphoric acid according to the composite mixture that forms of certain ratio.
Acidulant has a series of advantages in animal produces, but in use also exist at present some problems, mainly comprise: common acidulant is absorbed too fast by the animal alimentary canal in animal body, major part namely is absorbed under one's belt, seldom can arrive the back segment alimentary canals such as animal small intestine, fully antibacterial the and growth promoting function of performance in metenteron; In common acidulant and feed, some alkaline active materials react, and it is caused certain destruction; Common acidulant wants to bring into play it and should produce effect, and usually larger addition need to be arranged in feed, has increased feed cost.
In order to make acidulant performance acidifying and bacteriostasis in animal alimentary canal better; people have carried out a series of researchs to the release tech that delays of acidulant in recent years; wherein coating technique is that outer surface at common compound acidulant superscribes the specific protective layer of one deck by suitable art for coating; the active ingredient of acidulant can be discharged lentamente along with the dissolving of clothing film in the alimentary canal of animal, and reduce in feed the reaction with other composition.
Coated acidulant capsulating material commonly used has fat, aliphatic acid and other common coated auxiliary material etc., usually adopt the technology of melt coating, be sprayed onto solid particles surface in the mode of spraying after these solid matters fusings or be pre-mixed after carry out spraying granulation.
Use above-mentioned melt coating method, the consumption of capsulating material fat and aliphatic acid is generally larger, the consumption of the capsulating materials such as coated acidulant capsulating material stearic acid as disclosed in CN200710029691 and beta-schardinger dextrin-reaches more than 40%, caused the content of the total effective acid of coated acidulant on the low side, coated acidulant organic acid total amount as disclosed in CN200310106338 is 45～53%.
For defects, the present invention utilizes film forming commonly used in medicine sustained release coating material and art for coating preferably, has proposed a kind of novel coated acidulant, and has provided its preparation method.
Summary of the invention
The purpose of this invention is to provide a kind of coated acidulant and preparation method thereof.
The present invention adopts film forming commonly used in medicine sustained release coating material and art for coating preferably, can exceed the consumption capsulating material, the weightening finish of acidulant solid particle is less, thereby makes acidulant keep larger effective acid total amount, has simultaneously slow release effect preferably.
Coated acidulant of the present invention comprises the coated layer on acidulant solid microparticle and acidulant solid microparticle surface, and described acidulant solid microparticle comprises the component of following parts by weight: lactic acid: 20～30 parts; Fumaric acid: 5～15 parts; Citric acid: 10～15 parts; Malic acid: 5～10 parts; Formic acid: 5～10 parts; Propionic acid: 5～10 parts; Silica: 25～30 parts; 2～3 parts of synergist.
Described coated layer comprises that ethyl cellulose and hydroxypropyl methylcellulose composite bed, the quality of described ethyl cellulose and the compound coatings of hydroxypropyl methylcellulose are 2%～4% of acidulant solid microparticle quality.。
The compound coatings of described ethyl cellulose and hydroxypropyl methylcellulose comprises ethyl cellulose and hydroxypropyl methylcellulose, and wherein the weight ratio of ethyl cellulose and hydroxypropyl methylcellulose is 1: 1～2.5;
In addition, outside described ethyl cellulose and hydroxypropyl methylcellulose composite bed, described coated layer also comprises enteric solubility polyacrylic resin layer; Generally, this area enteric solubility polyacrylic resin commonly used has acrylic acid resinⅡ, III number etc.Described enteric solubility polyacrylic resin coatings comprises the enteric solubility polyacrylic resin, and the quality of described enteric solubility polyacrylic resin coatings is 2%～3% of acidulant solid microparticle quality.
In addition, also comprise following one or more dressing additives in described enteric solubility polyacrylic resin coatings and described ethyl cellulose and the compound coatings of hydroxypropyl methylcellulose: caking inhibiter, dispersant, plasticizer and defoamer.The quality of described dressing additive is 10%～50% of its affiliated coatings quality.
Above-mentioned dressing additive is to add for the character such as firm, smooth that guarantees dressing, can select configuration packet clothing various additives commonly used, can select polyethylene glycol as caking inhibiter; Dispersant can be selected talcum powder, dolomol, titanium dioxide etc.; Plasticizer can be selected polyethylene glycol, propane diols, triethyl citrate etc.; Defoamer can be selected methyl-silicone oil etc.;
Described synergist is probiotics or origanum oil.Wherein, described microorganism formulation is this area probiotics commonly used, as Bacillus acidi lactici, bacillus subtilis formulation etc.
The present invention also provides the preparation method of above-mentioned coated acidulant, and the present invention adopts the macromolecular materials such as sustained-release matrix material and PH sensitive material, takes double-deck coating technique, makes coated acidulant.
Described preparation method comprises the steps:
(1) with lactic acid, fumaric acid, citric acid, malic acid, formic acid, propionic acid mix and blend, then the liquid that mixes is sprayed in the mixer that carrier silica is housed, fully mix, then sneak into synergist, obtain acidulant solid microparticle;
(2) mixed solid microparticle is added effective fluidized bed seed-coating machine, spray into ethyl cellulose with atomize and hydroxypropyl methylcellulose composite slow release framework material coating solution A is coated with under fluidized state, spray into again enteric solubility polyacrylic resin coating solution B after having sprayed.Wherein the weight of coating solution A is 30～50% of step (1) gained acidulant powder, and the weight of coating solution B is 50～70% of step (1) gained acidulant powder, obtains coated acidulant of the present invention.
Wherein: described coating solution A comprises that ethyl cellulose, hydroxypropyl methylcellulose, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of ethyl cellulose, hydroxypropyl methylcellulose, solvent and dressing additive is: 1: 1～2.5: 55～80: 0.8～2.0;
Described coating solution B comprises that enteric solubility polyacrylic resin, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of enteric solubility polyacrylic resin, solvent and dressing additive is: 1: 10～35: 0.5～2.0;
Described solvent is water and/or absolute ethyl alcohol.
Subsequently the solid particle that makes being crossed the packing of weighing after screen cloth (20 order) gets product.
Concrete, described coating solution A can adopt following formula: ethyl cellulose 1.5kg, and hydroxypropyl methylcellulose 1.5kg, PEG-60001kg, talcum powder 1kg, 95% ethanol 50kg, water 45kg, rear mistake 100 mesh sieves and get final product stir.
Described coating solution B adopts following formula acrylic acid resinⅡ 2.5kg, polyacrylic resinⅢ 2.5kg, and 95% ethanol 80kg, water 10kg, talcum powder 2kg, triethyl citrate 0.5kg, methyl-silicone oil 10ml, rear mistake 100 mesh sieves and get final product stir.
For guaranteeing to mix, adopted the liquid mixture with various acid to spray in solid silica with atomize in the present invention, but be not limited to this kind method.
Detect and find; should be coated with weightening finish average out to 5～6% by coated acidulant product; after testing, total effective acid content reaches more than 60%; in addition; should be coated with acidulant and mix rear sealing with sodium bicarbonate solid; swollen bag phenomenon do not occur in 48h, show its effective acid protection fully, the dressing sealing effectiveness is good.
After this coated acidulant entered in animal body, in the gastral low pH environment of leading portion, coated acidulant coating membrane was comparatively complete, and effective acid composition major part does not discharge.After arriving the metenteron of higher pH value, outer pH sensitive material coating membrane dissolving is broken, and the effective acid composition slowly releases by internal layer sustained-release matrix material, the antibacterial effect with improving the little ecology of animal alimentary canal of performance in whole metenteron.
Compared with prior art, the present invention has following advantage:
(1) adopt double-deck coating technique, total effective acid content is high, can reach more than 60% after after testing.
(2) capsulating material has the active ingredient organic acid of acidulant and protects preferably effect.
The specific embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.Specialize as nothing, the raw material that the present embodiment adopts is commercial.
Embodiment 1
With 30kg lactic acid, 10kg fumaric acid, 10kg citric acid, 9kg formic acid, 7kg propionic acid, 5kg malic acid mix and blend, then the liquid that mixes is sprayed in 29kg carrier silica, fully mix, then sneak into synergist probiotics (available from the very lucky feed corporation,Ltd in Jinan, intestines are peaceful and comfortable) 3kg.
Mixed solid microparticle is added effective fluidized bed seed-coating machine, spray into successively the compound coating solution A of 50kg ethyl cellulose and hydroxypropyl methylcellulose and 50kg enteric solubility polyacrylic resin coating solution B is coated with granulation under fluidized state.
Wherein, coating solution A preparation technology is: ethyl cellulose 1.5kg, and hydroxypropyl methylcellulose 1.5kg, PEG-60001kg, talcum powder 1kg, 95% ethanol 50kg, water 45kg, rear mistake 100 mesh sieves that stir are coating solution A; Coating solution B preparation technology is: acrylic acid resinⅡ 2.5kg, and polyacrylic resinⅢ 2.5kg, 95% ethanol 80kg, water 10kg, talcum powder 2kg, triethyl citrate 0.5kg, methyl-silicone oil 10ml, rear mistake 100 mesh sieves that stir are coating solution B.
The solid particle that makes is crossed the packing of weighing after 20 eye mesh screens to get product.
After testing, total acid content is 60.7%, moisture≤8%.
Embodiment 2
With 25kg lactic acid, 12kg fumaric acid, 11kg citric acid, 10kg formic acid, 7kg propionic acid, 5kg malic acid mix and blend, then the liquid that mixes is sprayed in 30kg carrier silica, fully mix, then sneak into synergist probiotics (available from the very lucky feed corporation,Ltd in Jinan, adding the bacterium benefit) 3kg.
Mixed solid microparticle is added effective fluidized bed seed-coating machine, spray into successively the compound coating solution A of 40kg ethyl cellulose and hydroxypropyl methylcellulose and 60kg enteric solubility polyacrylic resin coating solution B is coated with granulation under fluidized state.
Wherein, coating solution A preparation technology is: ethyl cellulose 1.5kg, and hydroxypropyl methylcellulose 2.5kg, PEG-60000.8kg, talcum powder 1kg, 95% ethanol 50kg, water 55kg, rear mistake 100 mesh sieves that stir are coating solution A;
Coating solution B preparation technology is: acrylic acid resinⅡ 2.5kg, and polyacrylic resinⅢ 2kg, 95% ethanol 80kg, water 20kg, talcum powder 2kg, triethyl citrate 1.5kg, methyl-silicone oil 20ml, rear mistake 100 mesh sieves that stir are coating solution B.
The solid particle that makes is crossed the packing of weighing after 20 eye mesh screens to get product.
After testing, total acid content is 60.5%, moisture≤8%.
Embodiment 3
With 20kg lactic acid, 15kg fumaric acid, 15kg citric acid, 10kg formic acid, 5kg propionic acid, 7kg malic acid mix and blend, then the liquid that mixes is sprayed in 28kg carrier silica, fully mix, then sneak into synergist origanum oil 2kg.
Mixed solid microparticle is added effective fluidized bed seed-coating machine, spray into successively the compound coating solution A of 30kg ethyl cellulose and hydroxypropyl methylcellulose and 70kg enteric solubility polyacrylic resin coating solution B is coated with granulation under fluidized state.
Wherein, coating solution A preparation technology is: ethyl cellulose 1.0kg, and hydroxypropyl methylcellulose 2.5kg, PEG-60001kg, talcum powder 1kg, 95% ethanol 50kg, water 35kg, rear mistake 100 mesh sieves that stir are coating solution A; Coating solution B preparation technology is: acrylic acid resinⅡ 3kg, and polyacrylic resinⅢ 1.5kg, 95% ethanol 70kg, water 13kg, talcum powder 2kg, triethyl citrate 0.5kg, methyl-silicone oil 10ml, rear mistake 100 mesh sieves that stir are coating solution B.
The solid particle that makes is crossed the packing of weighing after 20 eye mesh screens to get product.After testing, total acid content is 62.9%, moisture≤8%.
Embodiment 4
The coated acidulant 5g of embodiment 1-3 preparation is mixed respectively with sodium bicarbonate powder 5g, be contained in vacuum bag, vacuum packaging, room temperature was placed 48 hours, found that bag phenomenon that do not rise.Illustrate that coated layer is tight.
Embodiment 5
Investigate the effect of the coated acidulant of the present invention in animal produces.
Choose 72 of 21 age in days weanling pigs, be not divided at random 3 groups by body weight, sex, nest, be respectively: control group (not adding acidulant), test one group and (add 0.2% commercial acidulant, Anhui Tiger Biotechnology Co., Ltd., acidulant II type), two groups (coated acidulant that adds 0.2% embodiment 1 to make) of test.Relatively acidulant uses in 4 weeks weanling pig growth promotion and Antidiarrheic effect.Result of the test is as follows:
The impact of the coated acidulant consumption of table 1 on Production Performance of Weaning Pigs and diarrhoea situation
| Index | Control group | Plain edition | Coated type |
| Initial weight (kg) | 5.3 | 5.3 | 5.3 |
| End heavy (kg) | 13.8 | 14.2 | 14.5 |
| Feed intake | 466 | 492 | 509 |
| Daily gain | 304 | 318 | 329 |
| Feedstuff-meat ratio | 1.53 | 1.55 | 1.55 |
| A diarrhoea number of times | 68 | 42 | 31 |
| Diarrhea rate | 10.1 | 6.3 | 4.6 |
As seen from the above table, add 0.2% the coated acidulant product of basis in 21 age in days weanling pig daily rations, significantly improved feed intake and the daily gain in 0～4 week, reduced diarrhea rate, and its effect is better than common acidulant.Therefore add 0.2% coated acidulant and can significantly improve the production performance of animal in the weanling pig daily ration.
Claims (4)
1. coated acidulant comprises the coated layer on acidulant solid microparticle and acidulant solid microparticle surface, and described acidulant solid microparticle is comprised of the component of following parts by weight: lactic acid: 20 ~ 30 parts; Fumaric acid: 5 ~ 15 parts; Citric acid: 10 ~ 15 parts; Malic acid: 5 ~ 10 parts; Formic acid: 5 ~ 10 parts; Propionic acid: 5 ~ 10 parts; Silica: 25 ~ 30 parts; 2 ~ 3 parts of synergist;
Described coated layer comprises: ethyl cellulose and hydroxypropyl methylcellulose composite bed outside described ethyl cellulose and hydroxypropyl methylcellulose composite bed, also comprise enteric solubility polyacrylic resin coatings;
The quality of described ethyl cellulose and hydroxypropyl methylcellulose composite bed is 2% ~ 4% of acidulant solid microparticle quality; Described enteric solubility polyacrylic resin coatings comprises the enteric solubility polyacrylic resin, and the quality of this coatings is 2% ~ 3% of acidulant solid microparticle quality;
Described ethyl cellulose and hydroxypropyl methylcellulose composite bed comprise ethyl cellulose and hydroxypropyl methylcellulose, and wherein the weight ratio of ethyl cellulose and hydroxypropyl methylcellulose is 1:1 ~ 2.5;
Described enteric solubility polyacrylic resin coatings and described ethyl cellulose and hydroxypropyl methylcellulose composite bed also comprise following one or more dressing additives: caking inhibiter, dispersant, plasticizer and defoamer; The quality of described dressing additive is 10% ~ 50% of its affiliated coatings quality.
2. coated acidulant as claimed in claim 1, is characterized in that, described synergist is probiotics or origanum oil.
3. as the preparation method of the arbitrary described coated acidulant of claim 1-2, it is characterized in that, comprise the steps:
(1) with lactic acid, fumaric acid, citric acid, malic acid, formic acid, propionic acid mix and blend, then the liquid that mixes is sprayed in the mixer that carrier silica is housed, fully mix, then sneak into synergist, obtain acidulant solid microparticle;
(2) mixed solid microparticle is added effective fluidized bed seed-coating machine, spray into ethyl cellulose with atomize and hydroxypropyl methylcellulose composite slow release framework material coating solution A is coated with under fluidized state, spray into again enteric solubility polyacrylic resin coating solution B after having sprayed, obtain coated acidulant of the present invention;
Wherein: described coating solution A comprises that ethyl cellulose, hydroxypropyl methylcellulose, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of ethyl cellulose, hydroxypropyl methylcellulose, solvent and dressing additive is: 1:1 ~ 2.5:55 ~ 80:0.8 ~ 2.0;
Described coating solution B comprises that enteric solubility polyacrylic resin, solvent and one or more comprise the dressing additive of caking inhibiter, dispersant, plasticizer and defoamer; Wherein the mass ratio of enteric solubility polyacrylic resin, solvent and dressing additive is: 1:10 ~ 35:0.5 ~ 2.0;
Described solvent is water and/or absolute ethyl alcohol.
4. preparation method as claimed in claim 3, is characterized in that, in step 2) afterwards, comprise that also the coated acidulant that makes crosses screen cloth, packing.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615725A (en) * | 2003-11-15 | 2005-05-18 | 宜兴市天石饲料有限公司 | Acidifying agent for fooder additive |
| CN1969854A (en) * | 2006-11-30 | 2007-05-30 | 成都耐切尔生物技术有限公司 | Sustained release formulation of raltitrexed and preparation method thereof |
| CN101513222A (en) * | 2009-02-18 | 2009-08-26 | 麦仑（厦门）生物科技有限公司 | Feeding acidifier prepared by emulsifying technology and preparing method thereof |
| CN101524118A (en) * | 2009-04-24 | 2009-09-09 | 安徽泰格生物技术有限公司 | Acidulant for feed and preparation method therefor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110111026A1 (en) * | 2008-03-10 | 2011-05-12 | Adel Penhasi | Humidity-resistant drug formulations and methods of preparation thereof |
-
2010
- 2010-12-28 CN CN2010106224173A patent/CN102106461B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615725A (en) * | 2003-11-15 | 2005-05-18 | 宜兴市天石饲料有限公司 | Acidifying agent for fooder additive |
| CN1969854A (en) * | 2006-11-30 | 2007-05-30 | 成都耐切尔生物技术有限公司 | Sustained release formulation of raltitrexed and preparation method thereof |
| CN101513222A (en) * | 2009-02-18 | 2009-08-26 | 麦仑（厦门）生物科技有限公司 | Feeding acidifier prepared by emulsifying technology and preparing method thereof |
| CN101524118A (en) * | 2009-04-24 | 2009-09-09 | 安徽泰格生物技术有限公司 | Acidulant for feed and preparation method therefor |
Non-Patent Citations (1)
| Title |
|---|
| 李浙烽.包被和控释技术在饲料工业中的应用.《中国饲料》.2005,(第1期),32-33. * |
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