CN109673848A - A kind of enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof - Google Patents
A kind of enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof Download PDFInfo
- Publication number
- CN109673848A CN109673848A CN201811640463.9A CN201811640463A CN109673848A CN 109673848 A CN109673848 A CN 109673848A CN 201811640463 A CN201811640463 A CN 201811640463A CN 109673848 A CN109673848 A CN 109673848A
- Authority
- CN
- China
- Prior art keywords
- enteric
- acid
- starch
- tannic acid
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A23K40/35—Making capsules specially adapted for ruminants
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to field of feed, and in particular to a kind of feed enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof.Enteric capsulating material includes: Enteric Materials 10%~20%, grease 70%~80%, mineral material 2%~6% and starch 4%~8%.It is coated with using above-mentioned enteric capsulating material, the mass ratio that the tannic acid accounts for coating finished product is 40%~50%.Mineral material is added in coating material of the invention; play the role of improving pellet hardness and particle is avoided adhesion occur; mineral material will form protective shell in gastric juice simultaneously; gained intestinal sustained releasing tannic acid does not discharge under one's belt; the influence to animal digestion enzyme is reduced, while in the release of enteron aisle rear end, absorption, raw materials for production are few; simple production process, and cost is relatively low.
Description
Technical field
The invention belongs to field of feed, and in particular to a kind of feed enteric capsulating material, intestinal sustained releasing tannic acid
And preparation method thereof.
Background technique
Tannic acid, also known as tannin, tannic acid are a kind of water-soluble phenolic compounds, and molecular mass is 500~3000,
It is present in various plants.Research shows that tannic acid has the function of many beneficial, such as antibacterial, anti-oxidant, anti-for birds
Diarrhea, antiviral, anti parasitic etc..
Research of the tannic acid on piglet is relatively more, most research shows that adding 0.7 in the feed diet of piglet
The tannic acid of~1.5kg/t can promote its digestion, reduce diarrhea, improve production performance, reduce making for antibiotic and zinc oxide
Dosage.But the additive amount of the Hydrolysable Tannins of 0.7~1.5kg/t acid, production cost can significantly larger than add the oxygen of 2.0kg/t
Change zinc, therefore there is no relevant applications in market；In addition also have a lot research shows that adding tannic acid meeting in piglet diet
It is substantially reduced the feed intake of piglet, reduces production performance, reason may be a kind of anti-battalion of the tannic acid as feedstuff
The factor is supported, insoluble compound can be formed in conjunction with the protein in feed, to influence to digest, in addition tannic acid is entering
It, can also be by forming insoluble compound in intestinal mucosal surface, damaging stomach and intestine in conjunction with gastrointestinal mucosa protein after in animal body
Form reduces animal to the abilities of digestive and absorption of nutriment.Therefore it needs to make tannic acid stomach processing, concentrates tannic acid
In distal small intestine and big enteric release, the usage amount of tannic acid and the adverse effect to animal are reduced.
CN107125440A is mentioned with enteric coating coating tannic acid, since material cause can cross stomach, but it is used
Material is complicated and price is higher, and intestinal sustained releasing effect is poor, and production technology is complicated, thus is not commercially available effectively
Application.
Summary of the invention
In view of this, the present invention in view of the above technical problems, provides a kind of feed enteric capsulating material, intestinal sustained releasing list
Peaceful acid and preparation method thereof, gained intestinal sustained releasing tannic acid does not discharge under one's belt, influence of the reduction to animal digestion enzyme, while
The release of enteron aisle rear end absorbs, and raw materials for production are few, simple production process, and cost is relatively low.
To achieve the above object, the present invention takes technical solution below:
Enteric capsulating material of the invention, comprising: Enteric Materials 10%~20%, grease 70%~80%, mineral material
Material 2%~6% and starch 4%~8%.
Preferably, the enteric capsulating material, comprising: Enteric Materials 12%~15%, grease 77%~80%,
Mineral material 3%~5% and starch 5%~7%.
Further, the Enteric Materials be polyacrylic acid resin, hydroxypropyl methyl cellulose, phthalic acid ester,
Hydroxypropylmethylcellulose acetate methylcellulose, succinate ethyl butyrate, Glyceryl tributyrate, chitosan, shellac, PVAP (polyvinyl alcohol vinegar
Sour phthalic acid ester), cellulose and its derivates, CAP (cellulose acetate phthalate), HPMCP (hydroxypropyl methyl fiber
Plain peptide acid esters), 1,2,4 benzenetricarboxylic acid cellulose acetate, 1,2,4 benzenetricarboxylic acid hydroxypropyl methyl cellulose, acetate succinate
Cellulose, acetate succinate hydroxypropyl cellulose, methacrylate, methacrylic acid, acrylate, butyl acrylate, third
Olefin(e) acid resin, ethyl cellulose, triacetin, vinyl propionate, polyvinyl proprionate, polyvinyl acetate, poly- butyric acid
Vinyl acetate, carboxylic acid vinyl ester polymer, vinyl acrylate, vinylpyrrolidone and vinyl carboxylates polymer, acrylic acid
It is one or more of in vinyl ester polymers, vinyl methacrylate and its polymer or o- benzoic acid ethyl ester.
Further, it is C that the grease, which is carbon atom number,12~C28One of or it is a variety of.
Preferably, the grease be coconut oil, palm-kernel oil, peanut oil, rapeseed oil, maize germ oil, hydrogenated oil and fat,
Oil with hydrogenated soybean, hydrogenated rapeseed oil, rilanit special, hydrogenated groundnut, palm stearin, olive oil, linseed oil, castor oil or
One of glyceride is a variety of.
Further, the mineral material include: mountain flour, it is talcum powder, bentonite, montmorillonite, kaolin, titanium dioxide, light
The mixture of one of matter calcium carbonate, calcium stearate or zinc oxide or more than one arbitrary proportions composition.
Further, the starch includes: cornstarch, wheaten starch, rice starch, tapioca, waxy corn shallow lake
Powder, potato starch, small rice starch, cassava pre-gelatinized starch, Hydroxypropyl phosphate ester starch, acetate converted starch, crosslinking are formed sediment
The mixture of one or more of powder or Xin Xiji succinic acid starch sodium arbitrary proportion composition.
A kind of intestinal sustained releasing tannic acid is coated with using above-mentioned enteric capsulating material, and the tannic acid accounts for coating finished product
Mass percent be 40%~50%.It is preferred that the mass percent that tannic acid accounts for coating finished product is 46%.
The tannic acid is particle tannic acid, and mass percentage is 70%~75%.
The preparation method of intestinal sustained releasing tannic acid of the invention, comprising:
One, the preparation of coating solution:
By enteric material, grease first heating stirring dissolve, then with water emulsification, then add mineral material and stirred with starch
It mixes uniformly spare；
Two, it is coated the preparation of tannic acid: above-mentioned coating solution and tannin granulates being entered in seed-coating machine in proportion and wrapped
Clothing obtains.
Tannin granulates in the present invention can be that particle is made by modes such as spray drying, extruding, centrifugal granulatings.
Preferably, the present invention selects emulsification pump to emulsify, emulsification times are 1~2h.
Further, the mass ratio of the water and remaining material in coating solution is 2~3:1.
Water consumption is excessive, is not easy drying in fluidized bed coating, causes coated granule uneven, and adhesion is serious, dosage
Too small, coating material dissolution and emulsifying effectiveness are bad, and tannin granulates will be exposed to outside.
Further, the seed-coating machine is fluidized-bed coating machine.
Further, the intake air temperature of the fluidized-bed coating machine is controlled at 45~55 DEG C, and air outlet temperature is at 40 DEG C
Hereinafter, wind speed is at 25~50 hertz, 1~2 hour of Coating times.
Preferably, the intake air temperature control of the fluidized-bed coating machine is at 50 DEG C, air outlet temperature is at 35 DEG C, wind
Speed is at 45 hertz, 1~2 hour of Coating times.
The present invention discharges after completing coating, is sieved, and products obtained therefrom 100% is logical less than 5% to sieve with 100 mesh sieve by 20 meshes.
In the present invention, the tannic acid is yellow or light brown light granules, and odorless, micro- to have special odor, taste is extremely puckery,
It is dissolved in water and ethyl alcohol, is soluble in glycerol, is practically insoluble in ether, chloroform, benzene, aqueous solution and iron salt solutions meet and become blue-black
Color, the molecular weight of tannic acid are 1701.20,210~215 DEG C of fusing point, 187 DEG C of flash-point, and molecular formula C76H52O46。
Enteric coating tannic acid made of the present invention, in the solution of pH1~5.5, the dissolution scope control of tannic acid is 0
~50%, it is preferable that in the aqueous solution of pH2~4, the dissolution rate range of tannic acid is in 10-30%；In the water-soluble of pH6~7.5
In liquid, the release rate range of tannic acid is 50~100%, it is preferable that in the aqueous solution of pH6.2~7.0, the release of tannic acid
Rate range is 80~100%.
The invention has the benefit that
1, mineral material is added in coating material, play the role of improving pellet hardness and particle is avoided adhesion occur, together
When mineral material will form protective shell in gastric juice, resist gastric acid (strong acid) and the broken ring of coating material structure acted on, to subtract
Few particle is discharged and is disintegrated in gastric juice.When entering enteron aisle, the middle enteric material in coating can dissolve, in addition mineral material by
In the effect by gastric acid, also can fater disintegration, remaining tannic acid also uniformly released, and can enable obtaining for tannic acid in this way
It obtains and efficiently utilizes.
2, the present invention selects tannic acid 40%~50%, and mineral material, which accounts for 2%~6%, can guarantee that economy is imitated while effect
Benefit maximizes, if tannic acid accounting is very little, consumptive material is too many, causes cost excessively high.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with the embodiment of the present invention, to this hair
Bright technical solution work further clearly and completely describes.It should be noted that described embodiment is only the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
Embodiment 1
780 grams of maize germ oil, 120 grams of methacrylate heating stirring dissolution is added 2000 after dissolving completely
Then gram water adds 40 grams of talcum powder after emulsifying 1h, 60 grams of wheaten starch, which stirs evenly, is made coating solution, then will
This coating solution and 2 kilograms of tannin granulates enter coating fluidized bed simultaneously, maintain intake air temperature control at 50 ± 5 DEG C, out
Draught temperature is at 35 ± 5 DEG C；Wind speed is coated 1.5 hours, then discharges at 30 hertz, sieving, obtains 100% by 20 mesh
Sieve, less than the 5% logical product sieved with 100 mesh sieve.
Embodiment 2
780 grams of linseed oil, 140 grams of cellulose acetate phthalate heating stirring dissolution adds after dissolving completely
Enter 3000 grams of water, emulsifies 1.5 hours, then add 30 grams of bentonite, 50 grams of Hydroxypropyl phosphate ester starch stirs evenly
Coating solution is made.Then this coating solution and 1.9 kilograms of tannin granulates are entered simultaneously to coating fluidized bed, maintain air inlet temperature
Degree control is at 50 ± 5 DEG C, and air outlet temperature is at 35 ± 5 DEG C；Wind speed is coated 2 hours, then discharges at 25 hertz, and sieving obtains
To 100% by 20 meshes, less than the 5% logical product sieved with 100 mesh sieve.
Embodiment 3
800 grams of hydrogenated oil and fat, 120 grams of hydroxypropyl methyl cellulose peptide acid esters heating stirring dissolution adds after dissolving completely
Enter 3000 grams of water, emulsifies 1 hour, then add 30 grams of zinc oxide, 20 grams of Xin Xiji succinic acid starch sodium, 30 grams of wood
Potato gelatinized starch, which stirs evenly, is made coating solution, then enters this coating solution and 2.1 kilograms of tannin granulates simultaneously and is coated
Fluidized bed maintains intake air temperature control at 55 ± 5 DEG C, and air outlet temperature is at 35 ± 5 DEG C or less；Wind speed is at 45 hertz, coating 2
It a hour, then discharges, is sieved, obtain 100% by 20 meshes, less than the 5% logical product sieved with 100 mesh sieve.
For the technical effect for further verifying the present invention program, tested using following experiment:
1. MATERIALS METHODS
1.1, coating tannic acid is tested in the release of animal intestinal tract, assimilation effect:
Test process:
(1) it the preparation of simulate the gastric juice, intestinal juice: is prepared according to official method.
(2) simulate the gastric juice and simulated intestinal fluid experimental group experimental method: taking each 1g of sample to be added separately to 100mlpH is 3.2
Simulate the gastric juice and pH be 6.2 simulated intestinal fluid, sufficiently dissolve, be placed in 37 DEG C, shaken in 150r/min incubator respectively, according to
The experimental design time takes out liquid assay tannin acid content therein, calculates tannic acid dissolution rate.It tests, makes even in triplicate
Mean value is recorded in table 1.
Table 1 is in artificial gastro-intestinal Fluid, the release rate (%) of sample
As shown in table 1, the tannic acid sample of coating buffer coating of the invention, compared with blank group and CN107125540A,
With better intestinal sustained releasing effect, while can be preferably by stomach without being destroyed.
The experimental test of 1.2 pairs of Growth Performance of Weaning Piglets
2 experimental design of table
Note: 1, in basal diet drug is added: aureomycin 75ppm；2, tannic acid >=60% is coated
The weanling pig 144 (about 8.3kg/) that age in days is consistent, healthy is selected, 6 processing, every processing 2 are randomly divided into
A repetition, 12 piglets of every repetition.By the corresponding test daily ration of every group of experimental design (being shown in Table 2), the period is 17 days, test
Forward and backward every group of weighing.
1.2 test daily rations
3 basal diet of table
1.3 feeding management
Test pig house daily management is executed by pig farm normal procedure during test.Take the feeding of free choice feeding, free water
The method of feeding.Pig house sanitation and hygiene are kept, ventilation condition is good.Piglet diseases, death are observed and are recorded in timing daily during test
Situations such as.
1.4 measurement item
1.4.1 growth performance
Record feed intake, extremely naughty pig quantity and weight daily calculate each stage average daily gain, day consumption during test
Material, feedstuff-meat ratio and death and culling rate.
Average daily gain=(addition feed total amount-hopper remaining material)/(the column residue head number × total number of days of test+dead naughty
Pig's head number × test number of days)
Average daily gain=(column end weight-column initial weight+extremely naughty pig end weight)/(the column residue head number × total number of days of test+dead naughty
Pig's head number × test number of days)
Feedstuff-meat ratio=average daily feed intake/Average weight increasing a day
Death and culling rate=(dead to wash in a pan sum × 100%)/every group of piglet sum；
1.4.2 diarrhea rate
Record grice diarrhoea situation daily.
The total head of diarrhea rate=diarrhea × 100%/(testing total head number × total number of days of test).
1.4.3 appearance scores
Observe weekly it is relatively primary, according to the hair of pig, color, can be divided into it is poor, in, good, excellent 4 grades (scoring respectively 1,
2,3,4 points)；
1.5 data statistics and analysis
Test data is arranged using Excel 2013, carries out the one-factor analysis of variance with SPSS21.0 software, and adopt
Significance test of difference is carried out with Dun-can method, is as a result indicated with average ± standard error.
2, result and analysis
2.1 experimental result
Influence of the 4 different disposal group of table to suckling piglet production performance
As shown in Table 4, in piglet diet, the average end weight of 5 suckling piglet of processing group, average feed intake, average daily gain are bright
It is aobvious to be higher than other 5 groups；From feedstuff-meat ratio, 5 suckling piglet feedstuff-meat ratio of processing group is better than other 5 groups of control；From diarrhea rate, place
5 suckling piglet diarrhea rate of reason group is lower；The hair color appearance of each processing group suckling piglet is comprehensive all the result shows that originally without significant difference
Scheme of the invention is optimal.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of enteric capsulating material characterized by comprising Enteric Materials 10%~20%, grease 70%~80%, mine
Object material 2%~6% and starch 4%~8%.
2. enteric capsulating material according to claim 1, which is characterized in that the grease is that carbon atom number is C12~C28In
It is one or more.
3. enteric capsulating material according to claim 1, which is characterized in that the Enteric Materials are polyacrylic acid tree
Ester, hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate ethyl butyrate, three fourth of glycerol
Ester, chitosan, shellac, PVAP (polyvinyl acetate phthalate), cellulose and its derivates, CAP (phthalic acid second
Acid cellulose), HPMCP (hydroxypropyl methyl cellulose peptide acid esters), 1,2,4 benzenetricarboxylic acid cellulose acetate, 1,2,4- benzene front three
Sour hydroxypropyl methyl cellulose, acetate succinate cellulose, acetate succinate hydroxypropyl cellulose, methacrylate, methyl
Acrylic acid, acrylate, butyl acrylate, acroleic acid resin, ethyl cellulose, triacetin, vinyl propionate, poly- third
Vinyl acetate, polyvinyl acetate, poly- vinyl butyrate, carboxylic acid vinyl ester polymer, vinyl acrylate, vinylpyrrolidone
With polymer, vinyl ester polymer, vinyl methacrylate and its polymer or o- benzoic acid of vinyl carboxylates
It is one or more of in ethyl ester.
4. enteric capsulating material according to claim 1, which is characterized in that the grease is coconut oil, palm-kernel oil, flower
Oil generation, rapeseed oil, maize germ oil, hydrogenated oil and fat, oil with hydrogenated soybean, hydrogenated rapeseed oil, rilanit special, hydrogenated groundnut, palm fibre
One of palmitic acid tristearin, olive oil, linseed oil, castor oil or glyceride are a variety of.
5. enteric capsulating material according to claim 1, which is characterized in that the mineral material includes: mountain flour, talcum
One of powder, bentonite, montmorillonite, kaolin, titanium dioxide, precipitated calcium carbonate, calcium stearate or zinc oxide or more than one
The mixture of arbitrary proportion composition.
6. enteric capsulating material according to claim 1, which is characterized in that the starch includes: cornstarch, wheat shallow lake
Powder, rice starch, tapioca, waxy corn starch, potato starch, small rice starch, cassava pre-gelatinized starch, hydroxypropyl phosphorus
One or more of acid esters starch, acetate converted starch, crosslinked starch or Xin Xiji succinic acid starch sodium arbitrary proportion group
At mixture.
7. a kind of intestinal sustained releasing tannic acid, which is characterized in that be coated with using above-mentioned enteric capsulating material, the tannic acid accounts for
The mass percent for being coated with finished product is 40%~50%.
8. a kind of preparation method of intestinal sustained releasing tannic acid characterized by comprising
One, the preparation of coating solution:
By enteric material, grease heating and melting first, then with water emulsification, then add mineral material and starch stirring it is spare；
Two, it is coated the preparation of tannic acid: above-mentioned coating solution and tannin granulates being entered in seed-coating machine in proportion and are coated
It arrives.
9. preparation method according to claim 8, which is characterized in that the mass ratio of remaining material in the water and coating solution
For 2~3:1.
10. preparation method according to claim 8, which is characterized in that the intake air temperature control of the fluidized-bed coating machine
System at 45~55 DEG C, air outlet temperature at 40 DEG C hereinafter, wind speed is at 25~50 hertz, 1~2 hour of Coating times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811640463.9A CN109673848A (en) | 2018-12-29 | 2018-12-29 | A kind of enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811640463.9A CN109673848A (en) | 2018-12-29 | 2018-12-29 | A kind of enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109673848A true CN109673848A (en) | 2019-04-26 |
Family
ID=66190247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811640463.9A Pending CN109673848A (en) | 2018-12-29 | 2018-12-29 | A kind of enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109673848A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111248351A (en) * | 2020-03-21 | 2020-06-09 | 天津瑞益瑞美生物技术有限公司 | Coated compound acidifier and preparation method thereof |
| CN111466490A (en) * | 2020-04-23 | 2020-07-31 | 叶平凡 | Preparation of lactating sow feed additive |
| CN114304394A (en) * | 2021-12-14 | 2022-04-12 | 珠海天凯生物科技有限公司 | Coated enteric zinc oxide and preparation process thereof |
| CN115968970A (en) * | 2023-01-13 | 2023-04-18 | 西北农林科技大学 | Feed additive based on modified tannin composite plant extract and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050169971A1 (en) * | 2002-03-11 | 2005-08-04 | Hubert Thoma | Tasted masked veterinary solid compositions |
| CN101249109A (en) * | 2008-03-14 | 2008-08-27 | 华侨大学 | Lactobacillus reuteri hollow micro-capsule and its preparing method |
| KR20100044498A (en) * | 2008-10-22 | 2010-04-30 | 경상대학교산학협력단 | The manufacturing method of rumen protected choline chloride and product by method thereof |
| CN101828650A (en) * | 2010-04-30 | 2010-09-15 | 青岛根源生物技术有限公司 | Process for preparing temperature-resistant enteric coated enzyme preparation product |
| CN104397349A (en) * | 2014-10-31 | 2015-03-11 | 广东绿生源饲料科技有限公司 | Feeding intestinal tract sustained-release type compound acidifier and preparation method thereof |
| CN106359909A (en) * | 2016-10-31 | 2017-02-01 | 福建深纳生物工程有限公司 | Coated zinc oxide with high stomach passing rate and preparation method of coated zinc oxide |
| CN106491557A (en) * | 2016-11-03 | 2017-03-15 | 中国科学院西北高原生物研究所 | A kind of antineoplastic Swertiridoid A enteric capsules and its preparation technology |
| CN107125440A (en) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | A kind of feed addictive enteric coating tannic acid and preparation method thereof and a kind of feed |
-
2018
- 2018-12-29 CN CN201811640463.9A patent/CN109673848A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050169971A1 (en) * | 2002-03-11 | 2005-08-04 | Hubert Thoma | Tasted masked veterinary solid compositions |
| CN101249109A (en) * | 2008-03-14 | 2008-08-27 | 华侨大学 | Lactobacillus reuteri hollow micro-capsule and its preparing method |
| KR20100044498A (en) * | 2008-10-22 | 2010-04-30 | 경상대학교산학협력단 | The manufacturing method of rumen protected choline chloride and product by method thereof |
| CN101828650A (en) * | 2010-04-30 | 2010-09-15 | 青岛根源生物技术有限公司 | Process for preparing temperature-resistant enteric coated enzyme preparation product |
| CN104397349A (en) * | 2014-10-31 | 2015-03-11 | 广东绿生源饲料科技有限公司 | Feeding intestinal tract sustained-release type compound acidifier and preparation method thereof |
| CN107125440A (en) * | 2016-02-29 | 2017-09-05 | 湖南晶天科技实业有限公司 | A kind of feed addictive enteric coating tannic acid and preparation method thereof and a kind of feed |
| CN106359909A (en) * | 2016-10-31 | 2017-02-01 | 福建深纳生物工程有限公司 | Coated zinc oxide with high stomach passing rate and preparation method of coated zinc oxide |
| CN106491557A (en) * | 2016-11-03 | 2017-03-15 | 中国科学院西北高原生物研究所 | A kind of antineoplastic Swertiridoid A enteric capsules and its preparation technology |
Non-Patent Citations (2)
| Title |
|---|
| YUJI MURAKAMI: "Application of an enteric coat increases the resistance to gastric juices for", 《SENSORS AND ACTUATORS B: CHEMICAL》 * |
| 尹进朝: "中药肠溶制剂研究进展", 《中成药》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111248351A (en) * | 2020-03-21 | 2020-06-09 | 天津瑞益瑞美生物技术有限公司 | Coated compound acidifier and preparation method thereof |
| CN111466490A (en) * | 2020-04-23 | 2020-07-31 | 叶平凡 | Preparation of lactating sow feed additive |
| CN114304394A (en) * | 2021-12-14 | 2022-04-12 | 珠海天凯生物科技有限公司 | Coated enteric zinc oxide and preparation process thereof |
| CN115968970A (en) * | 2023-01-13 | 2023-04-18 | 西北农林科技大学 | Feed additive based on modified tannin composite plant extract and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109673848A (en) | A kind of enteric capsulating material, intestinal sustained releasing tannic acid and preparation method thereof | |
| CN107125440A (en) | A kind of feed addictive enteric coating tannic acid and preparation method thereof and a kind of feed | |
| ES2306079T3 (en) | GRANULATES CONTAINING STABILIZING FITASA FORMULATIONS. | |
| Paolucci et al. | Development of biopolymers as binders for feed for farmed aquatic organisms | |
| JPH03505664A (en) | Rumen - Stability Pellets | |
| CN106107055A (en) | A kind of feed additive enteric coating butanoic acid and preparation method and a kind of feedstuff | |
| CN107125461A (en) | A kind of feed addictive enteric coating tannin acid derivative and a kind of feed | |
| CN107072249A (en) | Animal feed and aquatic feeds | |
| CN109601763A (en) | A kind of high stability aquatic feeds particle and preparation method thereof | |
| CN110973369A (en) | Slow-release sodium butyrate suitable for aquatic animals and preparation method thereof | |
| CN106036208A (en) | Seeding feed for aquatic products and production method of seeding feed | |
| CN109673847A (en) | A kind of preparation process of intestinal sustained releasing acidulant | |
| CN110897048A (en) | Enteric sodium butyrate microcapsule and preparation method and application thereof | |
| CN112568328A (en) | Enteric coated nano zinc oxide particle and production method thereof | |
| CN111228234A (en) | Coated lidocaine and preparation method and application thereof | |
| CN103652366B (en) | A kind of stabilization micro-capsule coating Mercaptamine and preparation method thereof | |
| CN108902476B (en) | Slow-release sodium butyrate suitable for different livestock and poultry and preparation method thereof | |
| CN103118547A (en) | Protected alpha-amylase | |
| CN116391806A (en) | Coated tannic acid preparation for weaned pigs and preparation method and application thereof | |
| CN107410710A (en) | A kind of preparation method of phytase preparation | |
| CN112006166A (en) | Serine feed additive for improving survival rate and growth speed of piglets and application thereof | |
| CN109601714A (en) | A kind of feed addictive and preparation method thereof with bacteriostatic activity and improvement growth of animal performance | |
| CN109430560A (en) | A kind of zinc oxide feed addictive and its preparation method and application | |
| US20080044516A1 (en) | Granules of Hydrophilic Active Principle | |
| CN108740371A (en) | Enteric capsulating material, using coated zinc oxide of the capsulating material and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190426 |