CN102308916A - Novel enteric sustained-release pellet for feed and preparation method thereof - Google Patents
Novel enteric sustained-release pellet for feed and preparation method thereof Download PDFInfo
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- CN102308916A CN102308916A CN201110224338A CN201110224338A CN102308916A CN 102308916 A CN102308916 A CN 102308916A CN 201110224338 A CN201110224338 A CN 201110224338A CN 201110224338 A CN201110224338 A CN 201110224338A CN 102308916 A CN102308916 A CN 102308916A
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- zinc oxide
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000013268 sustained release Methods 0.000 title claims abstract description 16
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 16
- 239000008188 pellet Substances 0.000 title claims abstract description 13
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 61
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 27
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 15
- 239000002131 composite material Substances 0.000 claims abstract description 10
- 229920002472 Starch Polymers 0.000 claims abstract description 9
- 239000008107 starch Substances 0.000 claims abstract description 9
- 235000019698 starch Nutrition 0.000 claims abstract description 9
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000011787 zinc oxide Substances 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 18
- 230000008569 process Effects 0.000 claims description 17
- 239000011248 coating agent Substances 0.000 claims description 13
- 238000000576 coating method Methods 0.000 claims description 13
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- 239000000463 material Substances 0.000 claims description 11
- 239000011122 softwood Substances 0.000 claims description 8
- 235000002917 Fraxinus ornus Nutrition 0.000 claims description 7
- 239000006187 pill Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 5
- 239000002023 wood Substances 0.000 claims description 5
- 239000004014 plasticizer Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000012055 enteric layer Substances 0.000 claims description 2
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract description 22
- 239000011701 zinc Substances 0.000 abstract description 22
- 229910052725 zinc Inorganic materials 0.000 abstract description 22
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 abstract description 12
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract description 6
- 239000000661 sodium alginate Substances 0.000 abstract description 6
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- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
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- 244000241257 Cucumis melo Species 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
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- 235000013312 flour Nutrition 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- -1 galactomannan compound Chemical class 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
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- 230000008105 immune reaction Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 150000003272 mannan oligosaccharides Chemical class 0.000 description 1
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- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
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- 239000010959 steel Substances 0.000 description 1
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a novel enteric sustained-release zinc oxide-oligosaccharide composite pellet for feed and a preparation method thereof. The novel enteric sustained-release zinc oxide-oligosaccharide composite pellet for feed comprises: by weight, 38 to 75% of zinc oxide powder, 15 to 35% of oligosaccharide, 2 to 14% of starch, 1.5 to 5.5% of cellulose acetate-phthalate, 0.05 to 0.1% of sodium alginate, 4.5 to 9.5% of talcum powder, and 0.15 to 0.5% of diethyl phthalate. The novel enteric sustained-release zinc oxide-oligosaccharide composite pellet for feed has the advantages of good effects of dissolution in the enteric canal and good treatment effects.
Description
Technical field:
The present invention relates to a kind of novel feed with zinc oxide, the compound enteric sustained-release pellet of oligosaccharides and preparation method thereof; In feed, add bioavailability in the animal body that this kind sustained release pellet not only can improve zinc oxide; Simultaneously; Oligosaccharides in the micropill can improve the daily gain of animal, reduces material anharmonic ratio and diarrhea rate, has good economic use value.
Background technology:
Zinc is the constituent of 40 plurality of enzymes in the human body, processes such as it has participated in nucleic acid and protein is synthetic, energetic supersession, redox.Research shows that an amount of zinc can effectively promote the organism metabolism of animal, and the zinc that in feed, adds doses can promote intestinal villus and the enterocyte hyperplasia of piglet; Quicken to repair the intestinal mucosa and the fine hair damage that cause because of ablactation stress, significantly alleviated the generation of post-weaning diarrhea in piglet, stimulate piglet growth; Improve daily gain; And have good antibacterial action, thus reduced feedstuff-meat ratio, reduce production cost.
Because the zinc oxide bioavailability is lower, present feed producer adds the zinc oxide of high dose and suffers from diarrhoea to prevent piglet white scour in the weanling pig daily ration, thereby causes the abuse of zinc.The zinc that adds high dose in the feed can cause element metabolism disorders such as iron, copper in the piglet body; High zinc has the effect of antagonism calcium ion simultaneously; Have a strong impact on growth in piglets and grow, the zinc of high dose is difficult for absorbing in animal alimentary canal simultaneously, thereby causes environmental pollution with the ight soil discharge.Yu Yanhu (2003) research shows that the zinc that adds in the wean piglet diet in the production practices is up to 2500～3000mg/kg, and wherein about 90～95% zinc is discharged from ight soil.Though this high zinc daily ration is only fed several weeks; But the total amount of discharging zinc is quite high; Can cause the bad reaction of environmental pollution and animal; Therefore, from safeguarding food security and protection environmental, designing the high enteric zinc oxide sustained release pellet of a kind of bioavilability can address the above problem.
For a long time, grice diarrhoea is usually prevented and controlled to people's custom through in feed, adding antibiosis, promotes piglet growth.Yet; This traditional technological means has caused problems such as the damage of pig body intestinal mucosa epithelial cell, the decline of livestock products safety and environmental pollution; And wood oligose, galactomannan-oligosaccharide, manna oligosacchride, FOS are as the feed addictive kind of national regulation; Not only have and improve livestock and poultry alimentary tract flora and the function that promotes beneficial bacterium propagation, but also be good immunomodulator.
Wood oligose is a kind of novel feed addictive, is difficult for being decomposed, and has characteristics acidproof, heat-resisting, good stability; Researchs such as Zhang Xiujiang show; The feeding xylo-oligosaccharide can improve the intestine of young pigs environment, reduce wean back feed to piglet stress, promote the health of piglet; Improve its disease-resistant performance, reduce the grice diarrhoea rate.
Galactomannan-oligosaccharide is claimed the galactomannan compound sugar again, is the oligosaccharides that is connected and composed through glycosidic bond by galactomannan sugar and glucose.Hou Zhen equality is investigated the diversity of weanling pig enteric microorganism through the feeding galactomannan-oligosaccharide; The result shows; Galactomannan-oligosaccharide promotes the propagation of intestinal beneficial bacterium in animal body; Reduce enteric pathogenic bacteria, thereby improve the integrality of intestinal mucosa. regulate the animal immune reaction and improve the production performance of animal.
Manna oligosacchride is claimed mannan-oligosaccharides or grape manna oligosaccharide sugar again, extensively is present in konjaku flour, melon bean gum, sesbania gum and the multiple microorganism wall.You Jinming etc. discover, in feed, add sodium butyrate and manna oligosacchride, can strengthen the specific immune response of weanling pig to 0VA.Manna oligosacchride optionally promotes the propagation of beneficial bacterium, suppresses or the elimination pathogen.
FOS is claimed fructooligosaccharide or FOS again, is one type of Bifidobacterium MF, characteristic such as have low heat value, stable, noresidue, have no drug resistance.Tan Congling etc. add the FOS of doses in feed; Study its influence to growing swine production performance and immunity function, result of study shows, compares with control group; Add 0.3% in the growing swine diet; FOS can significantly improve serum IgA concentration, and the apparent digestibility of the growth performance of raising growing swine and diet thick protein, crude fat can strengthen immunity function of animal.
Therefore; Novel zinc oxide-oligosaccharides composite slow release the micropill of the present invention development promptly adds the oligosaccharides of doses in the zinc oxide sustained release pellet, can improve bioavailability in the animal body of zinc oxide; Can improve the livestock and poultry alimentary tract flora again and promote beneficial bacterium propagation; Improve the daily gain of animal, reduce material anharmonic ratio and diarrhea rate, have good economic use value.
Summary of the invention:
The present invention relates to a kind of novel feed with zinc oxide, the compound enteric sustained-release pellet of oligosaccharides and preparation method thereof, the weight proportion of concrete raw material is following:
Preparing medicine material preferred weight percent of the present invention is:
Zinc oxide, oligosaccharides, starch are prepared the slowly-releasing ball heart according to the above ratio, and sustained-release coating layer is made up of slow-release material, lubricant, antiplastering aid and plasticizer, and wherein the filmogen of the enteric layer of sustained-release coating layer is a cellulose acetate-phthalate; Lubricant and antiplastering aid are talcum powder; Then preferred sodium alginate of plasticizer and diethyl phthalate.
The zinc oxide that the present invention relates to-oligosaccharides composite slow release micropill by containing pill core and sustained-release coating layer constitutes, is characterized in that described ball core is made up of zinc oxide, oligosaccharides and starch, and wherein, the percentage that zinc oxide content accounts for ball heart gross weight is 38%-75%; The percentage that oligosaccharide content accounts for ball heart gross weight is 15%-35%.
The present invention relates to a kind of preparation method of zinc oxide sustained release pellet, may further comprise the steps:
1, mixes
Press recipe quantity, zinc oxide, oligosaccharides and starch are joined in the mixer, mixed 10 minutes, for use.
2, preparation softwood
Mixed zinc oxide is placed in the granulator, add hot water and process softwood.
3, extruding is round as a ball
With softwood based in the extruder, be extruded into granular or strip after, place spheronizator round as a ball.
4, drying
With the micropill after round as a ball drying machine inner drying 30 minutes.
5, sieve
Micropill is crossed 30 orders and 80 mesh sieves, place in the clean polybag, and weighing.
6, the preparation of coating solution
(1) solvent is placed rustless steel container.
(2) stir with agitator, slowly coating material is added in the solvent, notice in the interpolation process that agglomerate produces, continuous stirring is up to dissolving fully, and is labelled subsequent use.
7, dressing
The zinc oxide micropill is placed in the coating pan, start coating pan, preheating.
Use the coating solution of step 6 preparation to carry out dressing, wherein the peristaltic pump rotating speed of coating pan is 20rpm, and compressed air pressure is 40psi, and the material bed tempertaure is 30-35 ℃, and the spray gun model is: W-71
8, drying
After coating solution has sprayed,, then micropill is placed on the basin, earlier in 40 ℃ of dried overnight coating pan inner drying 10 minutes.
9, sieve
Micropill is crossed 30 orders and 80 mesh sieves, place in the clean polybag, and weighing.
10, packing: woven bag packing, every bag of 20kg.
The specific embodiment:
1, zinc oxide-FOS composite slow release micropill
Preparation method: the described oxide powder and zinc of the foregoing description, FOS and starch are mixed by prescribed dose, and place mixer-granulator; Add hot water and process softwood; Through the extruding, round as a ball, dry, sieve and process the zinc oxide micropill of diameter between 0.3-0.9mm; Coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, process enteric-coated micro-pill, the micropill diameter of processing is controlled between the 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
2, zinc oxide, galactomannan-oligosaccharide composite slow release micropill
Preparation method: the described oxide powder and zinc of the foregoing description, galactomannan-oligosaccharide and starch are mixed by prescribed dose, and place mixer-granulator; Add hot water and process softwood; Through the extruding, round as a ball, dry, sieve and process the zinc oxide micropill of diameter between 0.3-0.9mm; Coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, process enteric-coated micro-pill, the micropill diameter of processing is controlled between the 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
3, zinc oxide-wood oligose composite slow release micropill
Preparation method: the described oxide powder and zinc of the foregoing description, wood oligose and starch are mixed by prescribed dose, and place mixer-granulator; Add hot water and process softwood; Through the extruding, round as a ball, dry, sieve and process the zinc oxide micropill of diameter between 0.3-0.9mm; Coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, process enteric-coated micro-pill, the micropill diameter of processing is controlled between the 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
4, zinc oxide-manna oligosacchride composite slow release micropill
Preparation method: the described oxide powder and zinc of the foregoing description, manna oligosacchride and starch are mixed by prescribed dose, and place mixer-granulator; Add hot water and process softwood; Through the extruding, round as a ball, dry, sieve and process the zinc oxide micropill of diameter between 0.3-0.9mm; Coating material is made into the aqueous suspension of 10% concentration, stirs and add talcum powder, sodium alginate and diethyl phthalate down, keep stirring; The zinc oxide micropill is placed the dressing machine, start the dressing machine, carry out the hydrojet dressing, process enteric-coated micro-pill, the micropill diameter of processing is controlled between the 0.3-0.9mm.
The result: in simulated gastric fluid and simulated intestinal fluid, measure, specific as follows:
Claims (5)
1. a zinc oxide, oligosaccharides composite slow release micropill is characterized in that it is by the preparation of following weight proportion raw material, and be specific as follows:
Wherein, oligosaccharides comprises wood oligose, galactomannan-oligosaccharide, manna oligosacchride and FOS.
2. according to the described envelope type slow release micropill of claim 1, it is characterized in that wherein the weight proportion of each raw material is:
3. according to the described sustained release pellet of claim 1, the percentage that zinc oxide content accounts for ball core gross weight is 30%-70%; The percentage that oligosaccharide content accounts for ball heart gross weight is 15%-30%.
4. enteric sustained-release pellet according to claim 1 describedly contains the weight ratio that pill core and enteric solubility material contain thing admittedly and is: 1: 0.03～0.08.
5. the preparation method of an enteric zinc oxide micropill may further comprise the steps:
1) the preparation ball heart:
Zinc oxide, the oligosaccharides of prescribed dose were mixed with starch 10 minutes, be placed in the granulator again, add hot water and process softwood, adopt the squeezing roll circule method to prepare the zinc oxide micropill, drying is sieved, and is for use;
2) preparation of coating solution:
Filmogen and the plasticizer of selecting the described enteric layer of claim 1 is made into the aqueous solution of 10% concentration by prescribed dose, stirs the talcum powder that adds prescribed dose down, stirs, and be for use;
3) micropill dressing:
The ball heart that step 1 is processed places the dressing machine, starts the dressing machine, by conventional dressing program dressing, processes enteric-coated micro-pill, and the micropill diameter of processing is controlled between 0.3～0.9mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102243381A CN102308916B (en) | 2011-08-04 | 2011-08-04 | Novel enteric sustained-release pellet for feed and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102243381A CN102308916B (en) | 2011-08-04 | 2011-08-04 | Novel enteric sustained-release pellet for feed and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102308916A true CN102308916A (en) | 2012-01-11 |
| CN102308916B CN102308916B (en) | 2013-08-28 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN103766606A (en) * | 2014-01-23 | 2014-05-07 | 浙江大学 | Feed additive capable for reducing emissions of nitrogen and ammonia in poultry farming |
| CN103766658A (en) * | 2014-01-23 | 2014-05-07 | 浙江大学 | Pig feed additive with low emissions of carbon and nitrogen |
| CN104922681A (en) * | 2015-05-23 | 2015-09-23 | 江苏南农高科动物药业有限公司 | Animal enteric film coating solution and preparation method as well as application thereof |
| CN108740371A (en) * | 2018-04-04 | 2018-11-06 | 广州智特奇生物科技股份有限公司 | Enteric capsulating material, using coated zinc oxide of the capsulating material and preparation method thereof |
| CN109805187A (en) * | 2019-01-09 | 2019-05-28 | 珠海天凯生物科技有限公司 | A kind of somatotrophic feed addictive of non-antibiotic class antibacterial |
| CN112262926A (en) * | 2020-11-03 | 2021-01-26 | 成都蜀星饲料有限公司 | Zinc oxide enteric-coated sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-coated sustained-release pellet |
| CN114532448A (en) * | 2022-03-11 | 2022-05-27 | 重庆威迪特药业有限责任公司 | Powder-coated zinc oxide preparation with high gastric hyperacidity rate as well as preparation method and application thereof |
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2011
- 2011-08-04 CN CN2011102243381A patent/CN102308916B/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
| CN103766606A (en) * | 2014-01-23 | 2014-05-07 | 浙江大学 | Feed additive capable for reducing emissions of nitrogen and ammonia in poultry farming |
| CN103766658A (en) * | 2014-01-23 | 2014-05-07 | 浙江大学 | Pig feed additive with low emissions of carbon and nitrogen |
| CN104922681A (en) * | 2015-05-23 | 2015-09-23 | 江苏南农高科动物药业有限公司 | Animal enteric film coating solution and preparation method as well as application thereof |
| CN108740371A (en) * | 2018-04-04 | 2018-11-06 | 广州智特奇生物科技股份有限公司 | Enteric capsulating material, using coated zinc oxide of the capsulating material and preparation method thereof |
| CN108740371B (en) * | 2018-04-04 | 2021-07-30 | 广州智特奇生物科技股份有限公司 | Enteric coating material, zinc oxide coated by coating material and preparation method thereof |
| CN109805187A (en) * | 2019-01-09 | 2019-05-28 | 珠海天凯生物科技有限公司 | A kind of somatotrophic feed addictive of non-antibiotic class antibacterial |
| CN112262926A (en) * | 2020-11-03 | 2021-01-26 | 成都蜀星饲料有限公司 | Zinc oxide enteric-coated sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-coated sustained-release pellet |
| CN112262926B (en) * | 2020-11-03 | 2023-08-04 | 成都蜀星饲料有限公司 | Zinc oxide enteric sustained-release pellet, preparation method thereof and feed composition containing zinc oxide enteric-release pellet |
| CN114532448A (en) * | 2022-03-11 | 2022-05-27 | 重庆威迪特药业有限责任公司 | Powder-coated zinc oxide preparation with high gastric hyperacidity rate as well as preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN102308916B (en) | 2013-08-28 |
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