CN108740371B - Enteric coating material, zinc oxide coated by coating material and preparation method thereof - Google Patents
Enteric coating material, zinc oxide coated by coating material and preparation method thereof Download PDFInfo
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- CN108740371B CN108740371B CN201810302103.1A CN201810302103A CN108740371B CN 108740371 B CN108740371 B CN 108740371B CN 201810302103 A CN201810302103 A CN 201810302103A CN 108740371 B CN108740371 B CN 108740371B
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- zinc oxide
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the technical field of feed additives, and particularly discloses an enteric coating material, which comprises the following components in part by weight: 30-40% of enteric material, 50-60% of fatty acid, 4-7% of medium-strength acid salt and 3-6% of talcum powder. The enteric coating material is used for coating to obtain coated zinc oxide, and the mass ratio of the zinc oxide to the coated finished product is 70-75%. The coated zinc oxide obtained by the invention has medium-strength acid salt in the coating material, plays a role in buffering gastric acid to damage the structure of the coating material, is not easy to collapse the network structure of the polymer coating material during gastric hyperacidity so as to cause the zinc oxide to be difficult to release in intestines, when the zinc oxide enters the intestinal tract, the medium-strength acid salt in the coating is replaced by the gastric acid, the network structure of the coating material is kept intact, a part of the zinc oxide firstly escapes from the network structure, and the rest zinc oxide is uniformly released along with the gradual dissolution of the coating material by intestinal juice, so that the problem of high-efficiency utilization of the zinc oxide can be effectively solved.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to an enteric coating material, zinc oxide coated by the coating material and a preparation method thereof.
Background
The zinc oxide is added into the feed, and the main purposes are as follows: effectively reduces the diarrhea of the weaned pigs, improves the growth speed of the weaned pigs, reduces the death rate, and partially replaces the application of antibiotics. It is known that the reason why zinc oxide can play the role of anti-diarrhea is that molecular zinc oxide is absorbed in intestinal tract, and if zinc oxide molecule is allowed to enter intestinal tract smoothly, it must avoid the gastric acid to destroy it to play its role. In the feed for weaned piglets, high-dose zinc oxide (2000-3000 ppm) is usually added to achieve the purpose, so that a large amount of unused zinc is discharged into the environment along with excrement, and environmental pollution is caused. With the increasing requirements of national environmental protection, the feeding mode is difficult to continue, people seek a method for more efficiently utilizing zinc oxide, CN101803684A mentions that zinc oxide is coated by enteric-coated materials, and the damage of gastric acid to zinc oxide can be overcome due to the coating materials, but the coating mode has the problem of difficult release in intestinal juice; CN102125171A also has similar problems with intestinal fluid release as described above; CN102318750A is through adopting the coating submicron order zinc oxide, and cubic shielding agent handles zinc oxide and can make the coating have fine tolerance to gastric acid, and has certain improvement to intestinal absorption, but release zinc oxide still has the defect in the intestines, and current technique still can not solve zinc oxide high efficiency and utilize and environmental protection pollution problem completely, meets the obstacle in the popularization in the market.
Disclosure of Invention
In view of the above, there is a need to provide an enteric coating material, zinc oxide coated by the enteric coating material, and a preparation method thereof, wherein the zinc oxide coated by the enteric coating material can effectively avoid the damage of gastric acid to the zinc oxide, and is very easy to release and absorb by intestinal tract.
In order to achieve the purpose, the invention adopts the following technical scheme:
the enteric coating material of the invention comprises: 30-40% of enteric material, 50-60% of fatty acid, 4-7% of medium-strength acid salt and 3-6% of talcum powder.
Preferably, the enteric coating material comprises: 32-35% of enteric material, 57-60% of fatty acid, 5-7% of medium-strength acid salt and 3-5% of talcum powder.
The fatty acid is one or more of medium-chain fatty acids and long-chain fatty acids with the carbon number of C8-C21.
Preferably, the fatty acid is at least one of coconut oil, palm kernel oil, stearic acid, palmitic acid, oleic acid and olive oil.
Further, the enteric material is at least one of CAP (cellulose acetate phthalate), HPMCP (hydroxypropylmethylcellulose peptidate), PVAP (polyvinyl acetate phthalate), and the like.
Further, the medium strength acid salts include: one or more than one of sodium citrate, sodium succinate, sodium adipate, sodium fumarate, sodium benzoate and potassium sorbate in any proportion.
The coated zinc oxide is coated by adopting the enteric coating material, and the mass ratio of the zinc oxide to a coated finished product is 70-75%.
Preferably, the mass ratio of zinc oxide in the finished coated product is 72%.
Further, the zinc oxide is nano zinc oxide.
The preparation method of the coated zinc oxide comprises the following steps:
step 1, preparation of coating liquid: dissolving enteric-coated materials and fatty acid in ethanol, adding moderate-strength acid salt and talcum powder, and stirring for later use;
step 2, preparation of coated zinc oxide: and (3) putting the coating liquid and zinc oxide into a coating machine in proportion for coating to obtain the zinc oxide zinc-zinc composite coating.
Further, the mass ratio of the ethanol to the rest materials in the coating liquid is 3-4: 1. The ethanol dosage is too large, so that the coating is not easy to dry in the fluidized bed coating process, the coated particles are not uniform, the adhesion is serious, the dosage is too small, the coating material is not well dissolved, and the zinc oxide can be exposed outside.
Further, the coating machine is a fluidized bed coating machine.
Furthermore, the temperature of an air inlet of the fluidized bed coating machine is controlled to be 50-60 ℃, the temperature of an air outlet is controlled to be below 35 ℃, the wind speed is 25-50 Hz, and the coating time is 1-2 hours.
Preferably, the temperature of an air inlet of the fluidized bed coating machine is controlled to be 60 ℃, the temperature of an air outlet is controlled to be 25 ℃, the wind speed is controlled to be 45 Hz, and the coating time is 1.5 hours.
The invention discharges and screens after coating, 100 percent of the obtained product passes through a 20-mesh screen, and less than 5 percent of the product passes through a 100-mesh screen.
The invention has the beneficial effects that:
1. the coating material contains medium-strength acid salt which plays a role in buffering gastric acid (strong acid) to break the structure of the coating material, the reticular structure of the polymer coating material is not easy to collapse during gastric hyperacidity so as to cause the zinc oxide to be difficult to release in intestines, when the polymer coating material enters the intestines, the medium-strength acid salt in the coating is replaced by the gastric acid, the reticular structure of the coating material is kept intact, the zinc oxide firstly escapes from the reticular structure, and the rest zinc oxide is uniformly released along with the gradual dissolution of the coating material by intestinal juice, so that the problem of the high-efficiency utilization of the zinc oxide can be effectively solved.
2. According to the invention, 70% -75% of zinc oxide is selected, 4% -7% of medium-strength acid salt can ensure the effect and maximize the economic benefit, and if the zinc oxide accounts for too little, too much material is consumed, and the cost is too high.
3. The nano zinc oxide is beneficial to intestinal absorption.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be further clearly and completely described below with reference to the embodiments of the present invention. It should be noted that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Adding 3000 g of ethanol into 600 g of coconut oil and 300 g of HPMCP, stirring and dissolving, then adding 40 g of potassium sorbate and 60 g of talcum powder to prepare coating liquid, then simultaneously feeding the coating liquid and 3kg of nano zinc oxide into a coating fluidized bed, and maintaining the temperature of an air inlet at 55 +/-5 ℃ and the temperature of an air outlet at 25 +/-5 ℃; coating for 1 hour at the wind speed of 25 Hz, discharging, and sieving to obtain 100% of product passing through 20 mesh sieve and less than 5% of product passing through 100 mesh sieve.
Example 2
Dissolving 4000 g of ethanol and 500 g of palm kernel oil and 400 g of CAP (CAP) by stirring, adding 70 g of sodium fumarate and 30 g of talcum powder to prepare a coating solution, and then simultaneously feeding the coating solution and 3kg of nano zinc oxide into a coating fluidized bed, and maintaining the temperature of an air inlet at 50 +/-5 ℃ and the temperature of an air outlet at 25 +/-5 ℃; coating for 2 hours at the wind speed of 50 Hz, discharging, and sieving to obtain a product with 100 percent of passing through a 20-mesh sieve and less than 5 percent of passing through the 100-mesh sieve.
Example 3
3050 g of ethanol is taken, 500 g of stearic acid and 400 g of CAP are added, stirred and dissolved, 30 g of sodium citrate, 20 g of sodium succinate and 50 g of talcum powder are added to prepare coating liquid, then the coating liquid and 2.3 kg of nano zinc oxide simultaneously enter a coating fluidized bed, the temperature of an air inlet is maintained to be controlled at 60 ℃, and the temperature of an air outlet is kept below 25 ℃; coating for 1.5 hours at the wind speed of 45 Hz, discharging, and sieving to obtain a product with 100 percent of passing through a 20-mesh sieve and less than 5 percent of passing through a 100-mesh sieve.
In order to further verify the technical effect of the scheme of the invention, the following experiments adopt different processes to coat the zinc oxide on the growth performance and diarrhea of the weaned pigs.
1. Material method
1.1 Experimental design and grouping
TABLE 1 design of the experiments
Note: 1. adding medicines into the basic daily ration: aureomycin 75 ppm; 2. the coating zinc oxide is more than or equal to 70 percent
192 healthy weaned piglets of consistent age in days (about 8.3 kg/head) were selected and randomized into 8 treatments, 2 replicates each, with 12 piglets per replicate. The corresponding test ration was used for each group according to the test design (see table 1) with a period of 17 days, and each group was weighed before and after the test.
1.2 test daily ration
TABLE 2 basic daily ration
1.3 Breeding management
The test pigsty daily management during the test was performed according to the normal program of the pigsty. Adopts a feeding method of free food intake and free water drinking. Keep the pigsty clean and sanitary and has good ventilation condition. The disease, death, etc. of piglets were observed and recorded regularly every day during the test period.
1.4 items of measurement
1.4.1 growth Performance
Feed intake, number and weight of dead pigs were recorded daily, and average daily gain, daily feed consumption, feed-meat ratio and death and culling rate at each stage during the test period were calculated.
Average daily feed intake ═ total feed added-trough remainder)/(column remainder number x total number of test days + number of dead pigs x number of test days)
Average daily gain (weight at end of column-initial weight at end of column + weight at end of dead pan pigs)/(number of remaining heads at column x total days of test + number of heads of dead pan pigs x days of test)
Feed/average daily gain
The mortality and elimination rate (total mortality and elimination multiplied by 100%)/total number of piglets per group;
1.4.2 diarrhea Rate
Piglet diarrhea was recorded daily.
The diarrhea rate is the total number of diarrhea x 100%/(total number of trials x total number of days).
1.4.3 appearance rating
The pigs are observed and compared once a week and can be classified into 4 grades of poor, medium, good and excellent according to the hair and color of the pigs (the grades are respectively 1, 2, 3 and 4);
1.5 data statistics and analysis
The experimental data were collated using Excel 2010, single factor analysis of variance using SPSS16.0 software, and significance of differences tested using Dun-can with the results expressed as mean ± standard error.
2. Results and analysis
2.1 results of the experiment
TABLE 3 influence of different technologies of Zinc oxide on the piglet production Performance
As can be seen from Table 3, in the piglet diet, the average end weight, average feed intake and average daily gain of the piglets of the treatment group 7 are obviously higher than those of the piglets of the treatment groups 1-6; the feed-meat ratio of the piglet of the treatment group 7 is superior to that of the piglet of the control treatment group 1-6 in terms of feed-meat ratio; from the aspect of diarrhea rate, the diarrhea rate of the piglets of the treatment group 7 is lower; the appearance of the fur color of the piglets of each treatment group was not significantly different. From the effects of the treatment groups 7 and 8, the coated zinc oxide scheme provided by the invention can completely replace the conventional high-dose zinc oxide scheme, and the expected purpose is achieved.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. An enteric coating material, comprising: 30-40% of enteric material, 50-60% of fatty acid, 4-7% of medium-strength acid salt and 3-6% of talcum powder; the medium strength acid salts include: the mixture is composed of more than one of sodium citrate, sodium succinate, sodium adipate, sodium fumarate, sodium benzoate and potassium sorbate in any proportion.
2. The enteric coating material of claim 1, wherein the fatty acid is one or more of medium-chain and long-chain fatty acids having carbon atoms of C8-C21.
3. The enteric coating material of claim 1, wherein the enteric material is at least one of CAP, HPMCP, PVAP.
4. Zinc oxide coated with the enteric coating material of any of claims 1 to 3, wherein the zinc oxide accounts for 70 to 75% by weight of the coated product.
5. The coated zinc oxide of claim 4, wherein the zinc oxide is nano zinc oxide.
6. The process for the preparation of coated zinc oxide according to claim 4 or 5, characterized in that it comprises the following steps:
step 1, preparation of coating liquid: dissolving enteric-coated materials and fatty acid in ethanol, adding moderate-strength acid salt and talcum powder, and stirring for later use;
step 2, preparation of coated zinc oxide: and (3) putting the coating liquid and zinc oxide into a coating machine in proportion for coating to obtain the zinc oxide zinc-zinc composite coating.
7. The method for preparing coated zinc oxide according to claim 6, wherein the mass ratio of the ethanol to the rest materials in the coating solution is 3-4: 1.
8. The process for preparing coated zinc oxide according to claim 6 or 7, wherein the coating machine is a fluidized bed coating machine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810302103.1A CN108740371B (en) | 2018-04-04 | 2018-04-04 | Enteric coating material, zinc oxide coated by coating material and preparation method thereof |
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| CN201810302103.1A CN108740371B (en) | 2018-04-04 | 2018-04-04 | Enteric coating material, zinc oxide coated by coating material and preparation method thereof |
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| CN108740371B true CN108740371B (en) | 2021-07-30 |
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| CN110100965A (en) * | 2019-05-30 | 2019-08-09 | 福建丰久生物科技有限公司 | A kind of derma type essential oil organic acid composite feed additive and its preparation method and application |
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