CN109805187A - A kind of somatotrophic feed addictive of non-antibiotic class antibacterial - Google Patents
A kind of somatotrophic feed addictive of non-antibiotic class antibacterial Download PDFInfo
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- CN109805187A CN109805187A CN201910020786.6A CN201910020786A CN109805187A CN 109805187 A CN109805187 A CN 109805187A CN 201910020786 A CN201910020786 A CN 201910020786A CN 109805187 A CN109805187 A CN 109805187A
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Abstract
The invention discloses a kind of somatotrophic feed addictives of non-antibiotic class antibacterial, according to parts by weight, including following components: 1-20 parts of zinc oxide, 2-35 parts of aldehyde compound, 0.1-5 parts of adhesive of 20-80 parts of filler, 10-50 parts of coatingss, 8-30 parts of water.Feed addictive of the present invention is added to that the ratio in feed is low, therefore the zinc oxide content in feed is also low, complies with standard；Feed addictive of the present invention avoids the destruction of gastric acid by coating technique, and after reaching small intestine, extended release coatings rupture reaches target administration purpose；In addition, feed addictive of the present invention can replace antibiotic treatment diarrhea, moreover it is possible to improve the appetite of livestock, while also have significant facilitation to the growth of livestock.
Description
Technical field
The invention belongs to animal feed additive field, in particular to a kind of somatotrophic feed of non-antibiotic class antibacterial adds
Add agent.
Background technique
With the promotion of people's Consciousness of food security, antibiotic additive is added in animal feeding-stuff to improve livestock
Disease resistance and speed of production are to be gradually prohibited.The additive containing zinc oxide is begun to use to substitute containing antibiosis in the prior art
The additive of element.Zinc oxide is a kind of feed addictive with antibacterial activity, is mainly used for preventing or control in aquaculture field
The diarrhea of wean pig is treated, the mechanism of action is to be destroyed microbial cell wall polysaccharide structures based on zinc oxide molecules, played antibacterial
Effect achievees the purpose that treat diarrhea.But zinc oxide through stomach when, can be destroyed by gastric acid, generate zinc ion, be unable to reach antibacterial
Effect, it is therefore desirable to zinc oxide is coated with, avoid zinc oxide in the degradation of gastric acid.
Have feed addictive in the prior art and use coated zinc oxide, but the feed addictive is added in feed
When need the content that the additive level that is added is high, and COMPREHENSIVE CALCULATING zinc oxide is added in feed to reach 1-2Kg/ tons of feeds.Oxygen
Change the too high levels of zinc, the excessively high main harm of zinc oxide content is that zinc oxide is not absorbed due to animal body in feed, most of
It excretes, causes zinc content in soil excessively high, contaminated land or river, contaminated soil can not recultivate, and interfere herding
The sustainable development of industry also influences environment.
According to the regulation of China's " feed addictive uses specification revision exposure draft safely ", explicitly points out and raised in cooperation
The highest limitation piglet, sow of zinc are not above 150mg/Kg (in terms of Zn-ef ficiency), other animals in material or full price mixed ration
200mg/Kg (in terms of Zn-ef ficiency) must not be higher than, also mean that and 2-3Kg oxide powder and zinc or 1-2Kg coating are added in feed per ton
Zinc oxide becomes history.Although the zinc oxide in feeds utilized additive also uses coated mode in the prior art, its
Coating effect is poor, and the content for generally requiring to improve additive in feed can be only achieved antibacterial to improve the content of zinc oxide
With somatotrophic effect, but the zinc oxide of high-content has very big destructiveness to soil after excreting, and cattle food is oxygen-containing
Change the too high health for being also unfavorable for people of zinc.Therefore it provides a kind of feed addictive of the coated zinc oxide containing low dosage, is then raised
Feed additives are added in feed with low dosage, to livestock reach antibacterial it is somatotrophic effect very it is necessary to.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of somatotrophic feed addictive of non-antibiotic class antibacterial.Institute
State feed addictive when in use, the additive amount in feed is very low, and satisfaction " solicit by feed addictive safe handling specification revision
Opinion original text " regulation.Meanwhile the somatotrophic effect of good antibacterial can be also played to livestock, in addition, also very friendly to environment
It is good.
A kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including following components:
Preferably, a kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including with the following group
Point:
It is further preferred that a kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including with
Lower component:
The partial size of the zinc oxide is 100 μm or less (preferably 20nm-10 μm).
The aldehyde compound refers to the compound containing aldehyde radical, preferably cinnamic acid, lauryl aldehyde, anisaldehyde, citral, vanilla
One or more of aldehyde, benzaldehyde；One or more of further preferred lauryl aldehyde, anisaldehyde, vanillic aldehyde, benzaldehyde.
The filler is selected from one or more of starch, dextrin, talcum powder, silica, lactose or calcium carbonate；It is excellent
Select one or more of starch, dextrin or lactose.
It is fine that described adhesive is selected from povidone (such as 30 POVIDONE K 30 BP/USP 15, K30, K45, K90), hydroxypropyl methylcellulose or hydroxypropyl
Tie up one or more of element.It is preferred that povidone or hydroxypropyl methylcellulose.
The coatingss are selected from stearic acid, hexadecanol, octadecyl alcolol, hydrogenated vegetable oil, single stearic acid glycerine lipoprotein, polyethylene glycol
One or more of (such as Macrogol 6000), beeswax or bar vinegar palm wax.It is preferred that stearic acid, hexadecanol, octadecyl alcolol, poly-
One or more of ethylene glycol 6000 or hydrogenated vegetable oil.
The present invention also provides a kind of preparation methods of somatotrophic feed addictive of non-antibiotic class antibacterial, including following step
It is rapid:
(1) each component is weighed by formula ratio, aldehyde compound, water and zinc oxide is stirred, then at 40-100 DEG C
Mixture A is made in lower standing 10-30 hours；
(2) the mixture A of step (1) preparation and filler are mixed, mixture B is made；
(3) adhesive is dissolved, is then added in mixture B, softwood is made, softwood is then placed in granulator
In, particle C is made；
(4) particle C is placed in seed-coating machine, it is 20-40 minutes round as a ball under 500-700 revs/min, obtain particle D；
(5) particle D is placed in drying at 65-75 DEG C, sieving obtains particle E；
(6) coatingss are placed at 70-90 DEG C and are heated, then particle E is placed in coating pan, coating solution is added, discharged,
Feed addictive of the present invention is made.
More specifically, a kind of preparation method of the somatotrophic feed addictive of non-antibiotic class antibacterial, comprising the following steps:
(1) each component is weighed by formula ratio, aldehyde compound and 5-15 parts of water is mixed, oxidation is then added
Zinc is stirred, and then stands 10-30 hours at 40-100 DEG C, and mixture A is made；
(2) the mixture A of step (1) preparation and filler are added in high efficiency wet granulator (efficient wet granulation
Machine is provided by Changzhou Zhi Yang mechanical equipment Co., Ltd, model GHL-30), in 500-1000 revs/min of (preferably 600-800
Rev/min) under be mixed 5-15 minutes, be made mixture B；
(3) adhesive is dissolved with water, is then added in mixture B, with 500-700 in high efficiency wet granulator
Rev/min (preferably 600 revs/min) mixing, while opening cutting revolving speed is 900-1100 revs/min (preferably 1000 revs/min
Clock), (function that high efficiency wet granulator is provided simultaneously with stirring and cutting) mixes 5-15 minutes (preferably 10 minutes), is made soft
Then softwood is placed in granulator by material, particle C is made；
(4) particle C centrifugal granulating seed-coating machine is placed in (to be provided by Changzhou Zhi Yang mechanical equipment Co., Ltd, model BZJ-
30) 20-40 minutes round as a ball under 500-700 revs/min (preferably 600 revs/min) (preferably 30 minutes) in, obtain rounding
Particle D；
(5) particle D is placed in baking oven the drying under 65-75 DEG C (preferably 70 DEG C), sieving obtains particle E；
(6) mode of coatingss heating water bath is heated at 70-90 DEG C, coating solution is made, be then placed in particle E
In coating pan (coating pan is defended and taught medical equipment Co., Ltd to provide by Beijing state, model WKY-600), coating solution is added,
Discharging, is made feed addictive of the present invention.
Preferably, the solution concentration when aldehyde compound wiring solution-forming is by mass percentage 10%-30%.
Preferably, described adhesive water dissolution is made into the solution that mass fraction is 2-10% (preferably 5%).
Preferably, the mesh number of particle C is 20-30 mesh (preferably 24 mesh).
Preferably, the mesh number being sieved in step (5) is 24-30 mesh.
The water content of the particle E is less than 10% (mass percent).
The coating process that step (6) carries out in coating pan is carried out at 70-90 DEG C.
The present invention is passivated coupling isomery processing using zinc oxide and aldehyde compound, imports conjugation aldehyde radical, occupy-place oxygen
Change zinc.Aldehyde radical is a nucleophilic group, is easily adsorbed by the hydrophilic group of pathogenic bacterial surface and penetrates cell wall to guide zinc oxide
It is implanted into pathogen cell wall, zinc oxide and conjugation aldehyde radical destroy the cell wall polysaccharide structure of pathogenic bacteria, fungi jointly, and then play
Antibacterial or bactericidal effect, and mammal does not have cell wall, therefore will not generate detrimental effect to the cell of human and animal.
In addition, avoiding the destruction of gastric acid by coating technique, after reaching small intestine, extended release coatings rupture reaches target administration
Therefore purpose can play good antibacterial somatotrophic effect feed addictive of the present invention is added in feed.
It avoids high agent zinc oxide and (phenomena such as skin is pale, coat slightly disorderly crimps, anaemia) is negatively affected to breeding performonce fo animals bring,
Influence of the animal excretion zinc to environment is also reduced simultaneously.
Compared with the existing technology, beneficial effects of the present invention are as follows:
(1) feed addictive of the present invention is added to that the ratio in feed is low, therefore the zinc oxide content in feed
It is low, meet the standard of " feed addictive uses specification revision exposure draft safely ".
(2) feed addictive of the present invention avoids the destruction of gastric acid by coating technique, after reaching small intestine, sustained release
Clothing rupture, reaches target administration purpose.
(3) feed addictive of the present invention can replace antibiotic treatment diarrhea, moreover it is possible to improve the appetite of livestock, while right
The growth of livestock also has significant facilitation.
Specific embodiment
In order to allow those skilled in the art that technical solution of the present invention is more clearly understood, now enumerates following embodiment and said
It is bright, it is pointed out that following embodiment does not constitute a limitation effect to the scope of protection of present invention.
Embodiment 1
A kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including following components:
The partial size of the zinc oxide is 20nm-40nm.
The coatingss are 2Kg Macrogol 6000 and 12Kg stearic acid.
A kind of preparation method of the somatotrophic feed addictive of non-antibiotic class antibacterial, comprising the following steps:
(1) each component is weighed by formula ratio, cinnamic acid and 6Kg water is mixed, zinc oxide is then added, stirring is mixed
It closes, then stands 10 hours at 40 DEG C, mixture A is made；
(2) the mixture A of step (1) preparation and starch are added in high efficiency wet granulator, at 700 revolutions per minute
It is mixed 5 minutes, mixture B is made；
(3) the remaining water of povidone is dissolved, is then added in mixture B, with 600 in efficient wet granulation
Rev/min mixing, while opening cutting revolving speed is 900 revs/min, mixes 10 minutes, softwood is made, be then placed in softwood
In grain granulator, particle C is made；
(4) particle C is placed in centrifugal granulating seed-coating machine, round as a ball 30 minutes under 600 revs/min, obtains of rounding
Grain D；
(5) particle D is placed in baking oven the drying at 70 DEG C, sieving obtains particle E；
(6) mode of coatingss heating water bath is heated at 80 DEG C, coating solution is made, particle E is then placed in packet
In clothing pot, coating solution is added, feed addictive of the present invention is made in discharging.
The mesh number of particle C is 24 mesh.
The mesh number being sieved in step (5) is 24-30 mesh.
The water content of the particle E is less than 10% (mass percent).
The coating process that step (6) carries out in coating pan is carried out at 80 DEG C.
Embodiment 2
A kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including following components:
The partial size of the zinc oxide is 100nm-10 μm.
The coatingss are 2.5Kg Macrogol 6000 and 15Kg hydrogenated vegetable oil.
A kind of preparation method of the somatotrophic feed addictive of non-antibiotic class antibacterial, comprising the following steps:
(1) each component is weighed by formula ratio, vanillic aldehyde and 6Kg water is mixed, zinc oxide is then added, stirring is mixed
It closes, then stands 30 hours at 50 DEG C, mixture A is made；
(2) the mixture A of step (1) preparation and dextrin are added in high efficiency wet granulator, under 800 revs/min
It is mixed 10 minutes, mixture B is made；
(3) the remaining water of hydroxypropyl methylcellulose is dissolved, is then added in mixture B, in efficient wet granulation
With 600 revs/min, while opening cutting revolving speed is 1000 revs/min, mixes 10 minutes, softwood is made, is then placed in softwood
In granulator, particle C is made；
(4) particle C is placed in centrifugal granulating seed-coating machine, round as a ball 30 minutes under 600 revs/min, obtains of rounding
Grain D；
(5) particle D is placed in baking oven the drying at 70 DEG C, sieving obtains particle E；
(6) mode of coatingss heating water bath is heated at 80 DEG C, coating solution is made, particle E is then placed in packet
In clothing pot, coating solution is added, feed addictive of the present invention is made in discharging.
The mesh number of particle C is 20-30 mesh.
The mesh number being sieved in step (5) is 24-30 mesh.
The water content of the particle E is less than 10% (mass percent).
The coating process that step (6) carries out in coating pan is carried out at 80 DEG C.
Embodiment 3
A kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including following components:
The partial size of the zinc oxide is 1 μm -10 μm.
The coatingss are 10Kg hexadecanol and 9Kg octadecyl alcolol.
A kind of preparation method of the somatotrophic feed addictive of non-antibiotic class antibacterial, comprising the following steps:
(1) each component is weighed by formula ratio, lauryl aldehyde and 7Kg water is mixed, zinc oxide is then added, stirring is mixed
It closes, then stands 10-30 hours at 80 DEG C, mixture A is made；
(2) the mixture A of step (1) preparation and lactose are added in high efficiency wet granulator, under 500 revs/min
It is mixed 5 minutes, mixture B is made；
(3) the remaining water of hydroxypropyl methylcellulose is dissolved, is then added in mixture B, in efficient wet granulation
It is mixed with 500 revs/min, while opening cutting revolving speed is 950 revs/min, mixes 5 minutes, softwood is made, then sets softwood
In granulator, particle C is made；
(4) particle C is placed in centrifugal granulating seed-coating machine, round as a ball 20 minutes under 500 revs/min, obtains of rounding
Grain D；
(5) particle D is placed in baking oven the drying at 65 DEG C, sieving obtains particle E；
(6) mode of coatingss heating water bath is heated at 70 DEG C, coating solution is made, particle E is then placed in packet
In clothing pot, coating solution is added, feed addictive of the present invention is made in discharging.
The mesh number of particle C is 20 mesh.
The mesh number being sieved in step (5) is 24 mesh.
The water content of the particle E is less than 10% (mass percent).
The coating process that step (6) carries out in coating pan is carried out at 70 DEG C.
Embodiment 4
A kind of somatotrophic feed addictive of non-antibiotic class antibacterial, according to parts by weight, including following components:
The partial size of the zinc oxide is 20nm-100nm.
The coatingss are 10Kg stearic acid and 10Kg hexadecanol.
A kind of preparation method of the somatotrophic feed addictive of non-antibiotic class antibacterial, comprising the following steps:
(1) each component is weighed by formula ratio, anisaldehyde and 5Kg water is mixed, zinc oxide is then added, stirring is mixed
It closes, then stands 30 hours at 100 DEG C, mixture A is made；
(2) the mixture A of step (1) preparation and talcum powder are added in high efficiency wet granulator, at 1000 revs/min
It is lower to be mixed 15 minutes, mixture B is made；
(3) the remaining water of hydroxypropyl methylcellulose is dissolved, is then added in mixture B, in efficient wet granulation
It is mixed with 700 revs/min, while opening cutting revolving speed is 1000 revs/min, mixes 10 minutes, softwood is made, then by softwood
It is placed in granulator, particle C is made；
(4) particle C is placed in centrifugal granulating seed-coating machine, round as a ball 40 minutes under 600 revs/min, obtains of rounding
Grain D；
(5) particle D is placed in baking oven the drying at 75 DEG C, sieving obtains particle E；
(6) mode of coatingss heating water bath is heated at 90 DEG C, coating solution is made, particle E is then placed in packet
In clothing pot, coating solution is added, feed addictive of the present invention is made in discharging.
The mesh number of particle C is 30 mesh.
The mesh number being sieved in step (5) is 30 mesh.
The water content of the particle E is less than 10% (mass percent).
The coating process that step (6) carries out in coating pan is carried out at 90 DEG C.
Embodiment 5
The safety testing of feed addictive of the present invention is tested.
Test small white mouse: Kun Ming mice, standard second level, weight 18g-20g, half male and half female, by Chinese drug biology
Product calibrating is provided.Male and female are randomly divided into six groups, every group 20 respectively.
Ration Compound: according to experimental animal mixed feed national standard, feed addictive prepared by embodiment 1 is added, is pressed
According to additive amount (i.e. embodiment 1 prepare feed addictive (g): feed (ton)) be respectively 0g:1 tons, 1000g:1 tons, 2000g:1
Ton, 3000g:1 tons, 4000g:1 tons, 5000g:1 tons be processed into pellet.It is freely eaten, is observed continuously 30 days, record feeding
Amount, death toll, the results are shown in Table 1.
Table 1:
| Average daily gain | Death toll | |
| 0g:1 tons | 5.31 | 0 |
| 1000g:1 tons | 6.05 | 0 |
| 2000g:1 tons | 6.11 | 0 |
| 3000g:1 tons | 6.06 | 0 |
| 4000g:1 tons | 6.04 | 0 |
| 5000g:1 tons | 6.07 | 0 |
As known from Table 1, the feed addictive that prepared by addition embodiment 1 effectively increases Kun Ming mice daily ingestion amount；
Feed addictive (g) prepared by embodiment 1: feed (ton) is 5000g:1 ton hour without Kun Ming mice death, shows safety.
Embodiment 6
The antibiotic property experimental test of feed addictive prepared by embodiment 1.
Feed addictive, commercially available similar-type products, quinocetone and the Bacitracin Zinc point prepared with same amount of embodiment 1
It is other that sensitization test test is carried out (according to 2015 editions marks of Chinese Pharmacopoeia general rules 1201 to same amount of Escherichia coli and Salmonella
Quasi- test), compare inhibition zone size (inhibition zone is bigger, and it is stronger to represent its bacteriostasis), the results are shown in Table 2.
Table 2:
| Escherichia coli | Salmonella | |
| Feed addictive prepared by embodiment 1 | 22mm | 21mm |
| Commercially available similar-type products | 16mm | 15mm |
| Quinocetone | 23mm | 22mm |
| Bacitracin Zinc | 13mm | 11mm |
From table 2 it can be seen that fungistatic effect of the feed addictive of the preparation of embodiment 1 to Escherichia coli and Salmonella
A kind of fungistatic effect of quinocetone (antibiotic) can be reached, and be significantly better than the fungistatic effect of commercially available similar-type products.
Embodiment 7
The test of minimal inhibitory concentration (MIC).
Feed addictive, commercially available similar-type products, the quinocetone of the preparation of embodiment 2 are antibacterial dense to the minimum of Escherichia coli
The comparison (according to 2015 editions 1201 standard testings of Chinese Pharmacopoeia general rule) of degree, the results are shown in Table 3.
Table 3:
| Original concentration (μ g/ml) | MIC(μg/ml) | |
| Feed addictive prepared by embodiment 2 | 1000 | 20 |
| Commercially available similar-type products | 1000 | 110 |
| Quinocetone | 1000 | 53 |
From table 3 it can be seen that the minimal inhibitory concentration (MIC) of feed addictive prepared by embodiment 2 is better than quinocetone.
Embodiment 8
In the case where carrying out manually pathogenic (diarrhea) to Kun Ming mice, using Different adding amount (such as 100g:1 tons of table
Show the feed addictive that 100g is added in feed per ton), the feed addictive and commercially available prepared respectively with the embodiment of the present invention 3
Similar-type products are added in feed, and the identical Kun Ming mice of raising health status counts Kun Ming mice in one week
Diarrhea rate and the death rate, as a result as shown in table 4 and table 5.
Table 4: the diarrhea rate and mortality results of commercially available similar-type products are used under Different adding amount
| Additive amount | 0g:1 tons | 100g:1 tons | 300g:1 tons | 500g:1 tons | 1000g:1 tons | 1500g:1 tons |
| Diarrhea rate | 71/72 | 69/72 | 56/72 | 38/72 | 30/72 | 21/72 |
| The death rate | 22/72 | 14/72 | 6/72 | 1/72 | 1/72 | 1/72 |
Table 5: the diarrhea rate and mortality results of the feed addictive prepared under Different adding amount using the embodiment of the present invention 3
From table 4 and table 5 as can be seen that when not adding feed addictive, the diarrhea rate of Kun Ming mice is up to 71/
72, the death rate is up to 22/72.In addition, after the feed addictive prepared using the embodiment of the present invention 3, the abdomen of Kun Ming mice
It rushes down rate and the death rate and is all significantly lower than commercially available similar-type products, and the feed addictive prepared using the embodiment of the present invention 3
Additive amount it is lower.
Embodiment 9
Product is to the wean somatotrophic measure of merit of pig.
Using pig of weaning as experimental subjects, it is added in feed using commercially available similar-type products, according to adding in feed per ton
2.5Kg is added to feed the pig on column number 5 and column number 6.Identical feed is added to using feed addictive prepared by the embodiment of the present invention 1
In, the pig on column number 7 and column number 8 is fed according to feed addition 0.5Kg per ton, the Gain weight of pig is counted after 30 days, as a result such as table 6
It is shown.Wherein, daily average weight gain (g)=(average weight (Kg)/30 of every pig after 30 days) * 1000；Feed/weight gain=30
Forage volume (Kg)/(the 30 days total average weight gains (Kg) * 20) of its consumption.
Table 6:
As can be seen from Table 6, feed is added to using feed addictive prepared by commercially available similar-type products and embodiment 1
Middle nursing pig, the daily average weight gain of corresponding every pig be not 708.3g and 726.7g, it is seen that using embodiment 1 prepare
Feed addictive is added to feed to feed pig, and the 18.4g that increase weight daily, daily gain improves 2.6% more, and the speed of growth of pig is more
Fastly.From the point of view of pig is measured with feed/weight gain to the conversion ratio of feed, the feed of commercially available similar-type products and the preparation of embodiment 1
Corresponding feed/the weight gain of the experimental group of additive is respectively 2.44 and 2.36, it is seen that every increase 1g weight, prepared by embodiment 1
The experimental group of feed addictive only needs 2.36g feed, and commercially available similar-type products experimental group needs 2.44g feed, it is seen that addition
For feed addictive prepared by embodiment 1 into feed, pig is better than commercially available similar-type products to the conversion ratio of feed.
Embodiment 10
" feed addictive uses specification revision exposure draft safely " is inner to explicitly point out in mixed feed or full mixing day
Highest limitation (mg/kg based on the element) piglet and sow 150, other animals 120 of zinc in grain.Also mean that feed per ton adds
Add 2-3kg zinc oxide or the coated zinc oxide of 1-2kg that will become history, because even being that (Zn content exists using coated zinc oxide
300-400g/kg) 500g (along in the compound trace quantity mineral substance element of feed addition zinc in 50-60ppm) be all highest limitation nothing
What method received.
(with the Mass Calculation of Zn-ef ficiency, zinc is far insufficient by maximum addition product of the present invention 1000g per ton in pannage
100g), in addition zinc 50-60ppm in the compound trace quantity mineral substance element of feed addition, does not transfinite, safely and effectively.
The middle oxide powder and zinc (fluorescent marker) that 3Kg is added per ton adds feed, feeds 20 piggys, every 500g, weight
Difference 0.1kg.1 hour acquisition stomach chyme, acquisition small intestine contents weight calculation in 3 hours.Extracted by organic matter separation, zinc oxide,
Fluorescent technique identification, molecular assay technology obtain as the result is shown: the amount of zinc oxide is to adopt in stomach chyme when piggy feeds 1 hour
The 5.2% of food；The amount of zinc oxide is the 3.8% of feeding in 3 hours small intestine contents after feed.Result above is also implied that small
The zinc oxide to work in intestines is the 3.8% of additive amount.95% or more zinc oxide is just transformed into other forms in stomach
Zinc ion does not have therapeutic effect.
Claims (10)
1. a kind of somatotrophic feed addictive of non-antibiotic class antibacterial, which is characterized in that according to parts by weight, including with the following group
Point:
2. feed addictive according to claim 1, which is characterized in that according to parts by weight, including following components:
3. feed addictive according to claim 1, which is characterized in that according to parts by weight, including following components:
4. feed addictive according to any one of claim 1-3, which is characterized in that the partial size of the zinc oxide is
100 μm or less.
5. feed addictive according to any one of claim 1-3, which is characterized in that the aldehyde compound is selected from meat
One or more of cinnamic aldehyde, lauryl aldehyde, anisaldehyde, citral, vanillic aldehyde, benzaldehyde.
6. feed addictive according to any one of claim 1-3, which is characterized in that the filler be selected from starch,
One or more of dextrin, talcum powder, silica, lactose or calcium carbonate.
7. feed addictive according to any one of claim 1-3, which is characterized in that described adhesive is selected from poly- dimension
One or more of ketone, hydroxypropyl methylcellulose or hydroxypropylcellulose；The coatingss be selected from stearic acid, hexadecanol, octadecyl alcolol,
One or more of hydrogenated vegetable oil, single stearic acid glycerine lipoprotein, polyethylene glycol, beeswax or bar vinegar palm wax.
8. a kind of preparation method of feed addictive described in any one of -7 according to claim 1, which is characterized in that including with
Lower step:
(1) each component is weighed by formula ratio, aldehyde compound, water and zinc oxide is stirred, it is then quiet at 40-100 DEG C
It sets 10-30 hours, mixture A is made；
(2) the mixture A of step (1) preparation and filler are mixed, mixture B is made；
(3) adhesive is dissolved, is then added in mixture B, softwood is made, then softwood is placed in granulator,
Particle C is made；
(4) particle C is placed in seed-coating machine, it is 20-40 minutes round as a ball under 500-700 revs/min, obtain particle D；
(5) particle D is placed in drying at 65-75 DEG C, sieving obtains particle E；
(6) coatingss are placed at 70-90 DEG C and are heated, then particle E is placed in coating pan, coating solution is added, discharged, is made
Feed addictive of the present invention.
9. preparation method according to claim 8, which is characterized in that the mixture A and filler in step (2) are efficient
In wet granulator, it is mixed 5-15 minutes under 500-1000 revs/min；It is added to after adhesive dissolution in step (3)
It is stirred in mixture B in efficient wet granulation with 500-700 revs/min.
10. preparation method according to claim 8, which is characterized in that the heating in step (6) is using heating water bath
Mode.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138642A (en) * | 2010-02-02 | 2011-08-03 | 广州市正百饲料科技有限公司 | Enteric zinc oxide micropills and preparation method thereof |
| CN102308916A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel enteric sustained-release pellet for feed and preparation method thereof |
| CN105454667A (en) * | 2015-12-12 | 2016-04-06 | 江苏雅博动物保健品有限责任公司 | Feed additive capable of replacing antibiotics and preparation method of feed additive |
| CN106535632A (en) * | 2014-03-21 | 2017-03-22 | 弗罗里达大学研究基金会有限公司 | Use of aldehydes formulated with nanoparticles and/or nanoemulsions to enhance disease resistance of plants to liberibacters |
-
2019
- 2019-01-09 CN CN201910020786.6A patent/CN109805187A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102138642A (en) * | 2010-02-02 | 2011-08-03 | 广州市正百饲料科技有限公司 | Enteric zinc oxide micropills and preparation method thereof |
| CN102308916A (en) * | 2011-08-04 | 2012-01-11 | 珠海天凯生物科技有限公司 | Novel enteric sustained-release pellet for feed and preparation method thereof |
| CN106535632A (en) * | 2014-03-21 | 2017-03-22 | 弗罗里达大学研究基金会有限公司 | Use of aldehydes formulated with nanoparticles and/or nanoemulsions to enhance disease resistance of plants to liberibacters |
| CN105454667A (en) * | 2015-12-12 | 2016-04-06 | 江苏雅博动物保健品有限责任公司 | Feed additive capable of replacing antibiotics and preparation method of feed additive |
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Application publication date: 20190528 |