CN105454667A - Feed additive capable of replacing antibiotics and preparation method of feed additive - Google Patents
Feed additive capable of replacing antibiotics and preparation method of feed additive Download PDFInfo
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- CN105454667A CN105454667A CN201510913345.0A CN201510913345A CN105454667A CN 105454667 A CN105454667 A CN 105454667A CN 201510913345 A CN201510913345 A CN 201510913345A CN 105454667 A CN105454667 A CN 105454667A
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Abstract
The invention discloses a feed additive capable of replacing antibiotics and a preparation method of the feed additive. The feed additive comprises components in parts by weight as follows: 40-60 parts of 1% allicin, 6-10 parts of cinnamyl aldehyde powder, 3-5 parts of 50% vitamin E acetate, 2.0-2.4 parts of D-calcium pantothenate, 5.60-5.68 parts of zinc oxide powder, 4-6 parts of see-enriched yeast and 25.14-25.18 parts of a carrier, namely, calcium carbonate powder. The feed additive can meet requirements of domestic animals such as chickens for nutrition and increase the growth speed and improve the anti-disease capacity.
Description
Technical field
The present invention relates to animal feed processing technique field, especially relate to a kind of alternative antibiotic feed addictive and preparation method thereof.
Background technology
Along with social development and growth in the living standard, people more and more pursue nutrition, healthy food, and animal product safety problem causes the extensive concern of the whole society, and feed safety ensures animal production safety and the stable basis of industrial economy by being.European Union starts to forbid that antibiotic uses as feed addictive for 2006.Federal Food and bureau of drug (FDA) determined from 2014, progressively forbade using PA in animal feed with triennium, and since 2000, Chinese Government also uses antibiotic kind to carry out significantly limiting to allowing in feed.Society need aquaculture provides animal product that is nontoxic, harmless, drug residue free, Feed Enterprise also using green, the safety a kind of means as sustainable development, the research and development of green, safety, functional feed product and promote and will become the development trend of feed industry.
Antibiotic adds in feed long-standing as antibacterial growth regulator.Over nearly 40 years, the extensive use of antibiotic etc feed addictive in animal feed, to control livestock and poultry generation, promote animal growth and development, improve raise economic benefit really play a positive role.Although antibiotic is very little as the consumption of feed addictive, calculate mainly with 1,000,000/(mg/kg) greatly, thing followed social effects of pollution are more and more outstanding: in (1) animal body, drug resistance pathogen is more and more, more and more stronger; (2) medicine remaining in meat, egg, milk directly threatens human health; (3) drug resistance pathogen contamination ambient influnence is to the health and safety of the mankind; (4) antibiotic and medicine directly cause animal autogenous infection or suprainfection.
Summary of the invention
The object of this invention is to provide a kind of alternative antibiotic feed addictive and preparation method thereof.
To achieve these goals, a kind of alternative antibiotic feed addictive of the present invention, comprise stock and adjunct, described raw material comprises the component of following weight portion: allicin 40-60 part of 1% mass concentration, cinnamic acid powder 6-10 part, vitamin e acetate 3-5 part of 50% mass concentration, D-VB5 calcium 2.0-2.4 part, oxide powder and zinc 5.60-5.68 part, Se-enriched yeast powder 4-6 part, described carrier and auxiliary material Paris white 25.14-25.18 part.
As the preferred technical solution of the present invention, described raw material comprises component 1% allicin 50 parts of following weight portion, 8 parts, cinnamic acid powder, 50% vitamin e acetate 4 parts, D-VB5 calcium 2.2 parts, oxide powder and zinc 5.64 parts, 5 parts, Se-enriched yeast powder, described carrier and auxiliary material Paris white 25.16 parts, its weight summation is 100 parts.
Present invention also offers a kind of preparation method of alternative antibiotic feed addictive, comprise the following steps:
1) raw material is got: get in proportion and meet quality standard, all kinds of raw materials through being up to the standards, comprise 1% allicin, cinnamic acid powder, 50% vitamin e acetate, D-VB5 calcium, oxide powder and zinc, Se-enriched yeast powder, Paris white;
2) feeding: after each supplementary material removes external packing, inner packing enters 300,000 grades of clean areas by logistics corridor;
3) sieve, weigh: 1% allicin, cinnamic acid powder, D-VB5 calcium, Se-enriched yeast powder are crossed 80 mesh sieves, weigh for subsequent use by formula rate; Weigh 50% vitamin e acetate by formula rate, oxide powder and zinc, Paris white are for subsequent use;
4) mix: D-VB5 calcium, oxide powder and zinc, Se-enriched yeast powder, 50% vitamin e acetate are fully mixed, obtains premix A; Cinnamic acid powder, half amount Paris white are mixed, obtains premix B; By after premix A, premix B, 1% allicin and remaining Paris white mixing 20min (rotating speed is 8 revs/min), discharging packs.
5) this product mixes with 1:1000 with terminal feed.
The beneficial effect that each component of the above-mentioned formula of the present invention is brought:
1,1% allicin
Through more than 200 kinds of natural plants screenings, there is stronger antibacterial ability, there is broad-spectrum antiseptic, antienzyme and antiprotozoan.The mechanism of action: 1, destroy-SH sulfydryl, 2, suppress the enzyme of sulfur-bearing, 3, the biosynthesis of T suppression cell film, 4, suppress archaeal dna polymerase.Pharmacology 1, MIC:12-50mg/ml, 2, enteron aisle effect: after absorption, in liver, change into diallyl sulfide, 3, do not have persister to produce, 4, lethal dose (LDSO): 10-20g/Kg/ days.
2, cinnamic acid powder
There is broad-spectrum antibacterial effect widely, adopt microcapsule granule proterties to be applied in product.The mechanism of action: after 1, cinnamic acid is absorbed, the flowing of blood in intestinal mucosa can be promoted, 2, by absorbing, cinnamic acid energy intense stimulus acth secretion adrenaline, 3, adrenergic stimulates decomposition of glycogen in liver to become glucose, the steatolysis of adipose tissue can be stimulated, increase the level of blood sugar and aliphatic acid.Cinnamic acid oil ingredient is on the impact of physiological mammal: 1, the main active of cinnamic acid oil is cinnamic acid and eugenol, and 2, in the vegetable oil of all common application, cinnamic acid oil and cinnamic acid have the highest antibacterial activity.
3,50% vitamin e acetate
Prevent in body metabolic processes in cell membrane and cell
unrighted acidoxidized Deng readily oxidizable substance, thus Cell protection film complete and then prevent old and feeble effect, can keep
reproductive organsnormal function.4, D-VB5 calcium
The metabolism of participation machine body fat and protein.Major function participates in the manufacture of energy, increases immunity, and assisted carbohydrate, fat and protein produce human body energy.It is the required nutriment of brain and nerve.
5, zinc oxide
The good reputation that zinc has " flowers of life ".Zinc is the activator of multiple enzyme, can promote that body growth is grown, and promotes the biosynthesis of nucleic acid and protein, strengthens immunity of organisms, very important to the growth of organism nervous system.
6, Se-enriched yeast
Selenium is the necessary trace element of body, has very important physiological function, closely related with the health of body.Selenium can prevention and prohibition tumour, anti-ageing, maintain the normal function of cardiovascular system, the appearance of prevention of arterial sclerosis and coronary heart disease.
7, calcium carbonate
Calcium carbonate, as a kind of calcium agent, is the auxiliary material source in the present invention.The kind in calcium source is a lot, and calcium carbonate calcium content is high, and bioavilability is good, has no side effect, and is a kind of good calcium source of very economical.It is consistent with the effect of BIOLOGICAL CALCIUM simultaneously, all can increase osteoporotic bone density.
In addition, a kind of alternative antibiotic feed addictive provided by the invention carries out mixing rear use with the mass ratio of 1:1000 with terminal feed.
Detailed description of the invention
A kind of alternative antibiotic feed addictive, comprise 1% allicin 500Kg, cinnamic acid powder 80Kg, 50% vitamin e acetate 40Kg, D-VB5 calcium 22Kg, oxide powder and zinc 56.4Kg, Se-enriched yeast powder 50Kg, carrier is Paris white 251.6Kg.
Its preparation method is as follows, gets raw material: get in proportion and meet quality standard, all kinds of raw materials through being up to the standards, comprise 1% allicin, cinnamic acid powder, 50% vitamin e acetate, D-VB5 calcium, oxide powder and zinc, Se-enriched yeast powder, Paris white; After each raw material removes external packing, inner packing enters 300,000 grades of clean areas by logistics corridor; Sieve, weigh: 1% allicin, cinnamic acid powder, D-VB5 calcium, Se-enriched yeast powder are crossed 80 mesh sieves, weigh for subsequent use by formula rate; Weigh 50% vitamin e acetate by formula rate, oxide powder and zinc, Paris white are for subsequent use; 50% vitamin e acetate of 22KgD-calcium pantothenate, 56.4Kg oxide powder and zinc, 50Kg Se-enriched yeast powder, 40Kg is fully mixed, obtains premix A; 80Kg cinnamic acid powder, 125.8Kg Paris white are mixed, obtains premix B; By after 1% allicin of premix A, premix B, 500Kg and remaining 125.8Kg Paris white mixing 20min (rotating speed is 8 revs/min), discharging packs.
During concrete use, this product is carried out weighing and proportioning with terminal feed with 1Kg:1000Kg and mixes rear to nursing broiler chicken.
Alternative antibiotic feed addictive described in patent of the present invention is as the efficiency assay analysis of growth accelerator on broiler production:
Note: medium and small female different person that writes represents significant difference with a line.
Conclusion:
The broiler chicken average daily gain of 1, feeding this patent feed addictive to be antibioticly eager to excel compared with antibiotic-free and having.
The average daily ingestion amount of broiler chicken of 2, feeding this patent feed addictive is compared with antibiotic-free and have antibiotic some more.
3, comparatively antibiotic-free is well a lot of for the broiler chicken death rate of nursing this patent feed addictive, and there comparatively have to be antibiotic slightly poorer.
Claims (7)
1. an alternative antibiotic feed addictive, is characterized in that: this feed addictive is made up of allicin, cinnamic acid powder, Vitwas E, D-VB5 calcium, oxide powder and zinc, Se-enriched yeast powder and carrier.
2. the alternative antibiotic feed addictive of one according to claim 1, is characterized in that: described carrier and Paris white.
3. the alternative antibiotic feed addictive of one according to claim 1, is characterized in that: the mass percentage concentration of described allicin is 1%.
4. the alternative antibiotic feed addictive of one according to claim 1, is characterized in that: described vitamin E to be mass percentage concentration be 50% vitamin e acetate.
5. the alternative antibiotic feed addictive of the one according to any one of claim 1-4, it is characterized in that, this additive comprises the component of following weight portion: allicin 40-60 part, cinnamic acid powder 6-10 part, vitamin e acetate 3-5 part, D-VB5 calcium 2.0-2.4 part, oxide powder and zinc 5.60-5.68 part, Se-enriched yeast powder 4-6 part, Paris white 25.14-25.18 part.
6. according to the alternative antibiotic feed addictive of the one described in claim 5, it is characterized in that, this additive comprises the component of following weight portion: allicin 50 parts, 8 parts, cinnamic acid powder, vitamin e acetate 4 parts, D-VB5 calcium 2.2 parts, oxide powder and zinc 5.64 parts, 5 parts, Se-enriched yeast powder, Paris white 25.16 parts.
7. a preparation method for alternative antibiotic feed addictive, is characterized in that, comprise the following steps:
1) raw material is got: get in proportion and meet quality standard, all kinds of raw materials through being up to the standards, comprise allicin, cinnamic acid powder, vitamin e acetate, D-VB5 calcium, oxide powder and zinc, Se-enriched yeast powder, Paris white;
2) feeding: after each supplementary material removes external packing, inner packing enters clean area by logistics corridor;
3) sieve, weigh: allicin, cinnamic acid powder, D-VB5 calcium, Se-enriched yeast powder are crossed 80 mesh sieves, weigh for subsequent use by formula rate; Weigh vitamin e acetate by formula rate, oxide powder and zinc, Paris white are for subsequent use;
4) mix: D-VB5 calcium, oxide powder and zinc, Se-enriched yeast powder, vitamin e acetate are fully mixed, obtains premix A; The Paris white of cinnamic acid powder, half weight is mixed, obtains premix B; After premix A, premix B, allicin and remaining Paris white mixing 20min, rotating speed is 8 revs/min, and discharging packs;
5) this product mixes with the mass ratio of 1:1000 with terminal feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510913345.0A CN105454667A (en) | 2015-12-12 | 2015-12-12 | Feed additive capable of replacing antibiotics and preparation method of feed additive |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510913345.0A CN105454667A (en) | 2015-12-12 | 2015-12-12 | Feed additive capable of replacing antibiotics and preparation method of feed additive |
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| CN105454667A true CN105454667A (en) | 2016-04-06 |
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| CN201510913345.0A Pending CN105454667A (en) | 2015-12-12 | 2015-12-12 | Feed additive capable of replacing antibiotics and preparation method of feed additive |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106107035A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | Cinnamic aldehyde feed additive, Preparation method and use |
| CN106107058A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | Cinnamic aldehyde emulsion feed additive, Preparation method and use |
| CN106578491A (en) * | 2016-10-28 | 2017-04-26 | 浙江大飞龙动物保健品股份有限公司 | Mixed feed additive for replacing antibiotics and preparation method of mixed feed additive |
| CN109805187A (en) * | 2019-01-09 | 2019-05-28 | 珠海天凯生物科技有限公司 | A kind of somatotrophic feed addictive of non-antibiotic class antibacterial |
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| CN1031791A (en) * | 1987-05-22 | 1989-03-22 | 上海第二制药厂 | The manufacture method of compound garlic feed additive (reinforced vitamin) |
| CN104171690A (en) * | 2014-08-06 | 2014-12-03 | 广州市信农生物科技有限公司 | Feed additive used for repelling mosquitoes and removing odor of pigsty |
| CN104381611A (en) * | 2014-12-01 | 2015-03-04 | 青岛普维动物保健品有限公司 | Animal feed additive replacing antibiotics |
| CN106107058A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | Cinnamic aldehyde emulsion feed additive, Preparation method and use |
-
2015
- 2015-12-12 CN CN201510913345.0A patent/CN105454667A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031791A (en) * | 1987-05-22 | 1989-03-22 | 上海第二制药厂 | The manufacture method of compound garlic feed additive (reinforced vitamin) |
| CN104171690A (en) * | 2014-08-06 | 2014-12-03 | 广州市信农生物科技有限公司 | Feed additive used for repelling mosquitoes and removing odor of pigsty |
| CN104381611A (en) * | 2014-12-01 | 2015-03-04 | 青岛普维动物保健品有限公司 | Animal feed additive replacing antibiotics |
| CN106107058A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | Cinnamic aldehyde emulsion feed additive, Preparation method and use |
Non-Patent Citations (2)
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| 孙罗美等: "肉桂醛的研究与应用", 《广东饲料》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106107035A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | Cinnamic aldehyde feed additive, Preparation method and use |
| CN106107058A (en) * | 2016-06-30 | 2016-11-16 | 临沂友康生物科技有限公司 | Cinnamic aldehyde emulsion feed additive, Preparation method and use |
| CN106578491A (en) * | 2016-10-28 | 2017-04-26 | 浙江大飞龙动物保健品股份有限公司 | Mixed feed additive for replacing antibiotics and preparation method of mixed feed additive |
| CN109805187A (en) * | 2019-01-09 | 2019-05-28 | 珠海天凯生物科技有限公司 | A kind of somatotrophic feed addictive of non-antibiotic class antibacterial |
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| CB02 | Change of applicant information |
Address after: No. 18, Jingjiang City, Jiangsu, Taizhou, Jiangsu Applicant after: Albert Jiangsu animal health technology limited liability company Address before: 214500, 61 Jiangshan Road, Taizhou, Jiangsu, Jingjiang Applicant before: ABRAM (JIANGSU) ANIMAL HEALTH CO., LTD. |
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Application publication date: 20160406 |
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