CN102138642A - Enteric zinc oxide micropills and preparation method thereof - Google Patents
Enteric zinc oxide micropills and preparation method thereof Download PDFInfo
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- CN102138642A CN102138642A CN2010190500124A CN201019050012A CN102138642A CN 102138642 A CN102138642 A CN 102138642A CN 2010190500124 A CN2010190500124 A CN 2010190500124A CN 201019050012 A CN201019050012 A CN 201019050012A CN 102138642 A CN102138642 A CN 102138642A
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Abstract
The invention discloses enteric zinc oxide micropills and a preparation method thereof. The enteric zinc oxide micropills comprise the following components: a) tablet cores and b) enteric coating layers on the outer layers, wherein the tablet cores comprise the following components in percentage by mass: 50 to 80 percent of zinc oxide and 20 to 50 percent of auxiliary materials; and the enteric coating layers are in an amount which is 5 to 15 percent of the total mass of the enteric zinc oxide micropills, and the grain diameters of the micropills are between 20 and 80 meshes. Enteric coats are not dissolved in stomachs and are dissolved in intestinal tracts, the zinc oxide is released and is dispersed in the intestinal tracts to form a protective film, and the protective film plays a role in astringency and antibacterium to reduce diarrhea of piglets. Each ton of feed for the piglets contains 2,500 to 3,000 grams of zinc oxide only by adding 200 to 500 grams of enteric zinc oxide micropills into each ton of feed for the piglets. The enteric zinc oxide micropills have the same effects as those of preventing the diarrhea and improving the growth performance of the piglets by the high-dose zinc oxide, are low in a using amount, better solve the side effect of high-content zinc, and provide an excellent zinc source product for feed industry.
Description
Technical field:
The present invention relates to a kind of feed addictive and preparation method thereof, be specifically related to a kind of enteric solubility zinc oxide micropill and preparation method thereof.
Background technology:
Feed grade zinc oxide be a kind of canescence to the yellow green powder, zinc oxide content is more than 95%.Zinc oxide is water insoluble, but is dissolved in acid.
Add the feed grade zinc oxide (as 3000mg/kg) of high dose in the weanling pig daily ration, to reducing grice diarrhoea, improving the piglet production performance has obvious effect.But there are many negative interactions in feed with high dose zinc oxide:
1. high zinc a large amount of hydrochloric acid in gastric juice that can neutralize, the reduction protease activities reduces the degree of hydrolysis of starch, is unfavorable for that nutrient digestion absorbs.
2. high zinc can form the chelating salt compound with the phytic acid in the feed, reduces the hydrolysis efficiency (Augspurgeret al.2004) of phytase in the feed.
3. the antagonism of high zinc can influence piglet to other trace elements absorbed, and it is uneven to cause copper, iron to absorb, and influences animal health.Particularly in zinc intake surpasses body during the discharge capacity of various excretory organs, electrolyte balance mechanism can be destroyed in the body, and ochrodermia will appear in piglet, by phenomenons such as thick disorderly curling, the anaemias of hair.
4. high zinc daily ration cause most of zinc with defecate in environment, cause environmental pollution, the zinc in soil content overproof from the angle of food chain, finally can work the mischief to human health.
Along with living standards of the people improve constantly, the food quality safety requirements is more and more tighter, No. 1224, Ministry of Agriculture bulletin " feed addictive safe handling standard ", also go with the stream ground clearly behind the regulation weaned piglet in preceding 2 all batches the zinc addition of zinc oxide form can not surpass 2250mg/kg.Yet after the zinc oxide addition reduced, the grice diarrhoea rate can rise significantly, and growth performance descends, and feed efficiency descends, and raiser's loss is very big.
Summary of the invention:
An object of the present invention is to provide a kind of enteric solubility zinc oxide micropill; this enteric solubility zinc oxide micropill is as feed addictive; can mix fully with feed; in enteron aisle, can in 1 hour, discharge fully; thereby the enteron aisle that effectively distributes rapidly; form diaphragm, play convergence and antibacterial action, thereby reduce grice diarrhoea.
Enteric solubility zinc oxide micropill of the present invention is made up of following composition:
By mass fraction 100%, comprise the label that the auxiliary material of the zinc oxide of 50%-80% and 20%-50% is formed, skin is an enteric coating layer, and described enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass, and the particle diameter of this enteric solubility zinc oxide micropill is the 20-80 order.
The particle diameter of described enteric solubility zinc oxide micropill is preferably the 20-60 order.
Described label preferably includes the zinc oxide of 70%-80% and the auxiliary material of 20%-30% by mass fraction 100%.
Auxiliary material in the described label comprises a kind of compound in talcum powder, aluminium oxide, alum, alphalise starch, dextrin, carboxymethyl cellulose, microcrystalline cellulose, Arabic gum, polyvinylpyrrolidone and polyacrylic acid and the derivative thereof at least.
Described enteric coating layer is by polyvinyl alcohol acetate phthalic acid ester, crylic acid resin is (as Eudragit L30D-55, Eudragit L100, Eudragit S100, methyl methacrylate, methacrylic acid and butyl acrylate), cellulose and derivative thereof are (as phthalic acid acetate fiber CAP, cellulose acetate benzenetricarboxylic acid ester CAT, butanedioic acid cellulose acetate CAS, butanedioic acid acetate hydroxypropyl methylcellulose HPMCAS, Opadry), stearic acid, at least a compound is as coating material in the Brazil wax.
According to the difference of coating material, can mix with some dispersants such as ethanol, castor oil, diethyl phthalate and Tween-80 and form coating solution, those skilled in the art can select according to general knowledge known in this field.
Zinc oxide of the present invention can use the zinc oxide of feed grade, its purity is more than 95%, the coating material and the dispersant of described label auxiliary material and enteric coating layer all are acceptable accessories and dispersant, belong to product well known in the art, can buy from the market.
Another object of the present invention provides the preparation method of described enteric solubility zinc oxide micropill, may further comprise the steps:
A) preparation of label:
After zinc oxide and auxiliary material weighed, mix, add entry, stir, make the wet granular softwood, extruding is granulated, and is round as a ball, drying and dehydrating, and 20 orders-80 purpose sheet slug particle is chosen in screening;
B) preparation of enteric coating liquid:
The coating material and the auxiliary material of enteric coating layer are mixedly configured into enteric coating liquid;
C) get label, according to conventional method enteric-coating layer in the enteric coating liquid of 0.2～2 times of label gross mass, control enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass, and the micropill in the 20-80 order scope is chosen in drying dehydration, screening, is enteric solubility zinc oxide micropill.
Described control enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass, and those skilled in the art use conventional method and are achieved according to the general knowledge of this area.
Enteric solubility zinc oxide micropill of the present invention be in appearance canescence to oyster particle or capsule, sphere or almost spherical can be used as a kind of feed addictive, its consumption is for to add 200～500g in pig starter feed per ton.
Enteric solubility zinc oxide micropill of the present invention, skin is one deck enteric coating, it is under stomach inner acidic environment (pH＜5.5); micropill does not dissolve, and zinc oxide does not disengage in the micropill, not in and hydrochloric acid in gastric juice; proteinase activity is increased, and protein digestibility improves, and growth performance improves; and under intestinal environment (pH＞5.5), the enteric coating dissolving all discharges zinc oxide; and be scattered in whole enteron aisle rapidly; form diaphragm, play convergence and antibacterial action, thereby reduce grice diarrhoea.
The present invention is according to Physiological Characteristics in Growing Pig and life habit and as the feature of feed addictive, work out enteric solubility zinc oxide micropill, this enteric solubility zinc oxide micropill is by mass fraction 100%, the label of forming by the auxiliary material of the zinc oxide of 50%-80% and 20%-50%, skin is an enteric coating layer, this enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass, and the particle diameter of this enteric solubility zinc oxide micropill is the 20-80 order.20～80 purpose particle diameters are convenient to do enteric coatings, and realizing suitability for industrialized production, and the enteric solubility zinc oxide of this particle size range is when low amount is added, easily and other compositions in the feed fully mix, guarantee the product result of use.The enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass; can guarantee that promptly the zinc oxide micropill can fully be coated; in the process of manufacture, as mix, be difficult for being peeled off; particle is non-friable; can also guarantee that enteric solubility zinc oxide micropill can all discharge in 1 hour under intestinal environment, rapidly, effectively be scattered in whole enteron aisle, form diaphragm; can rapidly, effectively play convergence and antibacterial action, reduce grice diarrhoea.
The present invention adopts the zinc oxide of certain content and the label that auxiliary material is formed, the enteric coating that outsourcing is specific, the enteric solubility zinc oxide micropill of selecting certain particle diameter and forming, only need add this enteric solubility zinc oxide micropill 200～500 grams at pig starter feed per ton, just can reach the effect of in pig starter feed per ton, adding 2500～3000 gram zinc oxide in the present prior art.Therefore enteric solubility zinc oxide micropill of the present invention not only has the effect of the anti-diarrhoea of high dose zinc oxide, raising piglet growth performance, and its consumption is low, has solved the side-effect problem of high zinc well, for feedstuff industry provides a kind of splendid zinc product-derived.This enteric solubility zinc oxide micropill, safety and environmental protection has reduced more than 80% the discharge capacity of zinc, and is environmentally safe, significantly reduces pollution.This product development utilizes, and will have a tremendous social and economic benefits.
The specific embodiment:
Below be to further specify to of the present invention, rather than the restriction to inventing.
Embodiment 1
Take by weighing the nano zine oxide 160kg of content 99%, 38kg microcrystalline cellulose, 2.0kg Sodium Polyacrylate add running water 60kg in trough type mixing machine, mix to form the wet granular softwood; Then the wet granular softwood after mixed is added in the oscillating granulator, be extruded into the material of column type chain form, then with round as a ball 15 minutes of column type chain form material input spheronizator with 60 order aperture screen clothes; Place 90 ℃ of baking oven inner dryings to get semi-finished product in 2 hours with rolling round material.Get 30～60 order semi-finished product 168kg after the screening, add in the fluidized-bed coating machine, spray into coating solution and carry out the processing of casing coating, the coating solution raw material is formed: acrylic resin I number: 10kg, acrylic resin II number: 10kg, 85% ethanol 300kg, castor oil: 3kg, diethyl phthalate: 4kg, Tween-80: 1.0kg.Treat that coating solution has sprayed, continued dry 1 hour that get 30～60 order enteric solubility zinc oxide micropill product 186kg after the screening, the quality of enteric coating layer accounts for 9.7% of enteric solubility zinc oxide micropill gross mass with 90 ℃ of temperature.
Embodiment 2
Take by weighing the nano zine oxide 103kg of content 99%, the 40kg microcrystalline cellulose, 54kg starch, 2.0kg Arabic gum, 4kg talcum powder add running water 60kg in trough type mixing machine, mix to form the wet granular softwood; Then the wet granular softwood after mixed is added in the oscillating granulator, be extruded into the material of column type chain form, then with round as a ball 10 minutes of column type chain form material input spheronizator with 20 order aperture screen clothes; Place 90 ℃ of baking oven inner dryings to get semi-finished product in 3 hours with rolling round material.Get 20～60 order semi-finished product 181kg after the screening, add in the fluidized-bed coating machine, spray into coating solution and carry out the processing of casing coating, the coating solution raw material is formed: acrylic resin I number: 5kg, acrylic resin II number: 5kg, 85% ethanol 180kg, castor oil: 2kg, diethyl phthalate: 3kg, Tween-80: 1.0kg.Treat that coating solution has sprayed, continued dry 1 hour that get 20～60 order enteric solubility zinc oxide micropill product 193kg after the screening, the quality of enteric coating layer accounts for 6.2% of enteric solubility zinc oxide micropill gross mass with 90 ℃ of temperature.
Embodiment 3
Take by weighing content 99% nano zine oxide 140kg, the 30kg microcrystalline cellulose, 24kg starch, 2.0kg polyvinylpyrrolidone, 4kg talcum powder add running water 50kg in trough type mixing machine, mix to form the wet granular softwood; Then the wet granular softwood after mixed is added in the oscillating granulator, be extruded into the material of column type chain form, then with round as a ball 10 minutes of column type chain form material input spheronizator with 40 order aperture screen clothes; Place 90 ℃ of baking oven inner dryings to get semi-finished product in 3 hours with rolling round material.After the screening 20～60 order semi-finished product 174kg, add in the fluidized-bed coating machine, spray into coating solution and carry out the casing coating and handle, the coating solution raw material is formed: stearic acid: 18kg, Brazil wax: 18kg sprays into dressing after being heated to 90 ℃ of whole fusions.Treat that coating solution has sprayed, continued dry 1 hour that get 20～60 order enteric solubility zinc oxide micropill product 204kg after the screening, the quality of enteric coating layer accounts for 14.7% of enteric solubility zinc oxide micropill gross mass with 90 ℃ of temperature.。
Embodiment 4
Take by weighing content 99% nano zine oxide 160kg, the 38kg microcrystalline cellulose, 1.0kg Sodium Polyacrylate, 1.0kg polyvinylpyrrolidone add running water 60kg in trough type mixing machine, mix to form the wet granular softwood; Then the wet granular softwood after mixed is added in the oscillating granulator, be extruded into the material of column type chain form, then with round as a ball 18 minutes of column type chain form material input spheronizator with 60 order aperture screen clothes; Place 90 ℃ of baking oven inner dryings to get semi-finished product in 2 hours with rolling round material.Get 40～60 order semi-finished product 165kg after the screening, add in the fluidized-bed coating machine, spray into coating solution and carry out the processing of casing coating, the coating solution raw material is formed: acrylic resin I number: 5kg, acrylic resin II number: 5kg, 85% ethanol 200kg, castor oil: 2kg, diethyl phthalate: 2kg, Tween-80: 1.0kg.Treat that coating solution has sprayed, continued dry 1 hour that get 40～60 order enteric solubility zinc oxide micropill product 176kg after the screening, the enteric coating layer quality accounts for 6.2% of enteric solubility zinc oxide micropill gross mass with 90 ℃ of temperature.
On July 12nd, 2009, on Boluo pig farm, Guangdong, select 120 of the big York summer sowing piggys of 21 ages in days wean, be divided into 4 processed group at random, each processed group is established 3 repetitions, and each repeats 10 pigs, carries out 30 days feeding experiment by a definite date.Experiment is a control group with normal diet level zinc oxide, adds 3000g/ ton feed; Test 1,2,3 group and use the enteric solubility zinc oxide micropill of present embodiment to add in the feed as additive respectively, its addition is respectively 200g/ ton feed, 350g/ ton feed, 500g/ ton feed.Under identical basal diet and feeding and management level, experimentize, with hundred poisonings colony house carried out disinfection before the test, experimental period the piglet free choice feeding, freely drink water, immune programme for children immunity routinely, piglet is in time treated when ill in discovery.
Carry out individuality by the hurdle by head and weigh when on-test (21 age in days) and off-test (51 age in days), empty stomach is 12 hours before weighing, and calculates test and respectively organizes piglet average weight and average daily the weightening finish.Every day, statistics was respectively organized the piglet feed consumption rate, calculated average daily feed intake, and according to each group feed intake and weightening finish, calculated feedstuff-meat ratio.At last, also to add up every day and respectively organize grice diarrhoea head number, calculate diarrhea rate.Result of the test is shown in table 1
The every index determining result of table 1 piglet
Annotate: diarrhea rate=total number of days of experimental period diarrhoea/experimental period, raised total number of days * 100;
Total feed intake of feedstuff-meat ratio=experimental period (kg)/experimental period total augment weight (kg)
As seen from Table 1, this enteric solubility zinc oxide micropill is reducing the grice diarrhoea rate, is improving daily gain and feed intake, is improving aspect such as feedstuff-meat ratio and all played good effect, with respect to normal diet level zinc oxide dosage 3000g/ ton feed, this enteric solubility zinc oxide micropill can reduce the addition of zinc in the daily ration significantly, improve efficiency of feed utilization, reduce pollution environment.Test finds that also the piglet hair of control group fed high dose common zinc oxide is coarse in disorder and longer, and skin color has the sign of turning white, and it is smooth submissive to use the test of enteric solubility zinc oxide micropill respectively to organize hair color, and skin is ruddy.
Experimental result shows that enteric solubility zinc oxide micropill when 200～500g/ ton feed consumption, can replace normal diet zinc oxide fully, is used to improve the production performance of piglet.
Claims (6)
1. an enteric solubility zinc oxide micropill is characterized in that, this enteric solubility zinc oxide micropill is made up of following composition:
A), comprise the label that the auxiliary material of the zinc oxide of 50%-80% and 20%-50% is formed by mass fraction 100%;
B) outer field enteric coating layer;
Described enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass, and the particle diameter of this enteric solubility zinc oxide micropill is the 20-80 order.
2. enteric solubility zinc oxide micropill according to claim 1, the particle diameter that it is characterized in that described enteric solubility zinc oxide micropill is the 20-60 order.
3. enteric solubility zinc oxide micropill according to claim 1 is characterized in that described label by mass fraction 100%, comprises the zinc oxide of 70%-80% and the auxiliary material of 20%-30%.
4. according to claim 1,2 or 3 described enteric solubility zinc oxide micropills, it is characterized in that auxiliary material in the described label comprises a kind of compound in talcum powder, aluminium oxide, alum, alphalise starch, dextrin, carboxymethyl cellulose, microcrystalline cellulose, Arabic gum, polyvinylpyrrolidone and polyacrylic acid and the derivative thereof at least.
5. according to claim 1,2 or 3 described enteric solubility zinc oxide micropills, it is characterized in that described enteric coating layer by at least a compound in polyvinyl alcohol acetate phthalic acid ester, crylic acid resin, stearic acid, the Brazil wax as coating material.
6. the preparation method of the described enteric solubility zinc oxide of claim 1 micropill is characterized in that, may further comprise the steps:
A) preparation of label:
Zinc oxide and auxiliary material are weighed, mix, add entry, stir, make the wet granular softwood, extruding is granulated, and is round as a ball, drying and dehydrating, and 20 orders-80 purpose sheet slug particle is chosen in screening;
B) preparation of enteric coating liquid:
The coating material and the auxiliary material of enteric coating layer are mixedly configured into enteric coating liquid;
C) get label, according to conventional method enteric-coating layer in 0.2～2 times enteric coating liquid of label gross mass, control enteric coating layer quality accounts for the 5-15% of enteric solubility zinc oxide micropill gross mass, and the micropill in the 20-80 order scope is chosen in drying dehydration, screening, is enteric solubility zinc oxide micropill.
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| CN102318750A (en) * | 2011-10-08 | 2012-01-18 | 成都巨星猪业有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN102335196A (en) * | 2011-10-25 | 2012-02-01 | 浙江大学 | Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method |
| CN102920665A (en) * | 2012-12-04 | 2013-02-13 | 四川省川龙动科药业有限公司 | Colon-targeted zinc oxide pellet and preparation method thereof |
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
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| CN104686808A (en) * | 2015-03-26 | 2015-06-10 | 无锡正大畜禽有限公司 | 50% enteric package zinc oxide nanoparticle preparation method |
| CN105639141A (en) * | 2015-12-29 | 2016-06-08 | 河南艾德昕生物科技有限公司 | Enteric-coated zinc oxide additive for feed and preparation method of additive |
| CN105961846A (en) * | 2016-05-27 | 2016-09-28 | 重庆新动生物技术有限公司 | Modified wrapped enteric-coated zinc oxide nanoparticle |
| CN106260599A (en) * | 2016-08-12 | 2017-01-04 | 广汉隆达饲料有限公司 | Enteric zinc oxide micropill |
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| CN109276561A (en) * | 2018-11-12 | 2019-01-29 | 浙江诚缘生物科技有限公司 | A kind of nano zine oxide enteric-coated micro-pill and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102318750A (en) * | 2011-10-08 | 2012-01-18 | 成都巨星猪业有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN102318750B (en) * | 2011-10-08 | 2013-06-05 | 成都巨星农牧科技有限公司 | Coated submicron feed-grade zinc oxide and preparation method thereof |
| CN102335196A (en) * | 2011-10-25 | 2012-02-01 | 浙江大学 | Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method |
| CN102920665A (en) * | 2012-12-04 | 2013-02-13 | 四川省川龙动科药业有限公司 | Colon-targeted zinc oxide pellet and preparation method thereof |
| CN102920665B (en) * | 2012-12-04 | 2014-06-11 | 四川省川龙动科药业有限公司 | Colon-targeted zinc oxide pellet and preparation method thereof |
| CN103549162A (en) * | 2013-11-02 | 2014-02-05 | 成都雪樱动物科技实业有限公司 | Novel feed additive and preparation method thereof |
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| CN104546907A (en) * | 2014-12-24 | 2015-04-29 | 浙江惠嘉生物科技有限公司 | Enteric nano zinc oxide preparation and preparation method thereof |
| CN104546907B (en) * | 2014-12-24 | 2017-10-10 | 浙江万方生物科技有限公司 | A kind of nano oxidized zinc preparation of enteric and preparation method thereof |
| CN104686808A (en) * | 2015-03-26 | 2015-06-10 | 无锡正大畜禽有限公司 | 50% enteric package zinc oxide nanoparticle preparation method |
| CN105639141A (en) * | 2015-12-29 | 2016-06-08 | 河南艾德昕生物科技有限公司 | Enteric-coated zinc oxide additive for feed and preparation method of additive |
| CN105961846A (en) * | 2016-05-27 | 2016-09-28 | 重庆新动生物技术有限公司 | Modified wrapped enteric-coated zinc oxide nanoparticle |
| CN106260599A (en) * | 2016-08-12 | 2017-01-04 | 广汉隆达饲料有限公司 | Enteric zinc oxide micropill |
| CN106474151A (en) * | 2016-11-16 | 2017-03-08 | 浙江丰虹新材料股份有限公司 | A kind of animal core shell structure zinc oxide clay antidiarrhoea formulation and preparation method thereof |
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| CN109276561A (en) * | 2018-11-12 | 2019-01-29 | 浙江诚缘生物科技有限公司 | A kind of nano zine oxide enteric-coated micro-pill and preparation method thereof |
| CN109511786A (en) * | 2019-01-04 | 2019-03-26 | 重庆威迪特药业有限责任公司 | A kind of feed addictive and preparation method thereof containing zinc oxide |
| CN109805187A (en) * | 2019-01-09 | 2019-05-28 | 珠海天凯生物科技有限公司 | A kind of somatotrophic feed addictive of non-antibiotic class antibacterial |
| CN111529548A (en) * | 2020-05-13 | 2020-08-14 | 上海美农生物科技股份有限公司 | Enteric zinc oxide particles |
| CN111529548B (en) * | 2020-05-13 | 2022-07-26 | 上海美农生物科技股份有限公司 | Enteric zinc oxide particles |
| CN112568328A (en) * | 2020-12-10 | 2021-03-30 | 无锡正大生物股份有限公司 | Enteric coated nano zinc oxide particle and production method thereof |
| CN112753865A (en) * | 2020-12-28 | 2021-05-07 | 湖南普菲克生物科技有限公司 | Coated copper sulfate for feed and preparation method thereof |
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Application publication date: 20110803 |