CN102335196A - Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method - Google Patents
Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method Download PDFInfo
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Abstract
The invention discloses use of supported nano zinc oxide as an anti-diarrhea agent for weaned pigs and a using method. According to the use of the supported nano zinc oxide as the anti-diarrhea agent for the weaned pigs, the supported nano zinc oxide is a composite material for supporting nano zinc oxide by using kaolin or montmorillonite or attapulgite or sepiolite or zeolite as a supporter. The zinc oxide accounts for 10 to 50 weight percent of the composite material for supporting the nano zinc oxide. The using method of the supported nano zinc oxide serving as the anti-diarrhea agent for the weaned pigs comprises that 160 to 800 mg/kg of supported nano zinc oxide based on zinc is added into a weaned pig feed. The supported nano zinc oxide can remarkably reduce the diarrhea rate of the weaned pigs, improve the daily gain, improve the form of the intestinal mucous membrane and protect the intestinal mucous membrane barrier; the fur of the pigs is red and bright; the toxic or side effect of high-zinc daily ration on the pigs is avoided; and the effect of the supported nano zinc oxide exceeds that of high-dose common zinc oxide, the consumption of the zinc oxide is greatly reduced, and zinc excretion and environmental pollution are reduced.
Description
Technical field
The present invention relates to purposes and the method for using of a kind of loaded nano zinc oxide as the ablactational baby pig anti-diarrhea agents.Be specifically a kind of be carrier with Kaolin, Montmorillonitum, attapulgite, meerschaum, zeolite etc., the composite of supported nano zinc oxide is as the purposes and the method for using of ablactational baby pig anti-diarrhea agents.
Background technology
Wean to piglet cause stress, be easy to cause " weaning syndrome of piglets ", cause piglet diarrhea, and then influence piglet growth.Wean back piglet becomes the edible solid daily ration by sucking breast milk, and this stress make piglet, and still the gut barrier of undeveloped mature is impaired; Simultaneously, the disappearance of maternal antibody also can reduce the resistance of piglet; The change of environment also can increase the touch opportunity of piglet and pathogen, and these all might cause piglet diarrhea.The permeability of the impaired back of piglet gut barrier intestinal mucosa increases, and can cause by the protein induced allergic diarrhea in the daily ration, forms vicious cycle like this, further aggravates the intestinal mucosa damage.The triple sensitivity that stress increase wean back piglet to potential pathogenic microorganism in the environment inevitably of nutrition, psychology and environment, the back piglet diarrhea causes weaning.Wean back piglet diarrhea is often followed the stagnation of piglet growth, produces cad pig when situation is serious, even causes piglet dead, and Swine Production is caused heavy economic losses.
The main means that solve diarrhea of weaned piglets at present are to use high dose zinc oxide (general 2000 ~ 3000 mg/kg).From Denmark scientist Poulsen (1989) report, zinc content 2500mg/kg (zinc oxide) can reduce since the sickness rate of ablactation piglet diarrhea in the diet, and the application of high zinc in animal produces is very extensive.Though the high dose zinc oxide is fairly obvious to the effect of prevention piglet diarrhea, unsuitable life-time service generally was no more than for 2 weeks, and life-time service can cause staple length, the colour of skin pale with harmful effect such as restriction late growing stage; Simultaneously the high dose zinc oxide also can influence absorbing of other constants and trace quantity mineral substance element, and the balance that this will inevitably destroy various trace element causes vitamin stability to reduce and the reduction etc. of tiring of other nutrients; High zinc makes animal be in the inferior clinical symptom of poisoning; In addition, zinc oxide since biology utilization rate lower, a large amount of zinc cause environmental pollution with defecate in environment.
Big both at home and abroad quantity research shows, ionic state zinc such as zinc sulfate though zinc chloride and organic zinc have an antibacterial effect external, do not have the diarrhea effect to ablactational baby pig.Most at present researchs think that only the Gao Xincai in zinc oxide source has diarrhea and growth promoting function, and reports that the bioavailability of zinc oxide in the various zinc source is minimum, and the zinc major part in the zinc oxide is discharged from feces.Many scholars think that the effect of zinc oxide is antibacterial relevant with astriction with it.Zinc oxide should be brought into play the diarrhea effect with molecular conformation, and its rate of dissociation under one's belt directly influences its action effect.Have only the high dose zinc oxide that convergence intestinal and fungistatic effect are just arranged, could partly keep away the disassociation of gastric acid, performance diarrhea effect zinc oxide.
Better bring into play it in order to reduce zinc oxide dosage to piglet diarrhea effect, product or technology such as existing microencapsulated coating zinc oxide, enteric coated zinc oxide, nano zine oxide.Peplos or coated zinc oxide make more zinc oxide effectively arrive at the effect of animal intestinal performance diarrhea through reducing zinc oxide disassociation under one's belt.Nano zine oxide is the new product of nanometer scale, on pig, chicken, studies to show that nano zine oxide can reduce the diarrhea of weaned piglets rate, improves the piglet fertility performance.But,, all await further raising though the said goods has certain effect on the ablactational baby pig diarrhea.
The loaded nano zinc oxide is to be carrier with Kaolin, Montmorillonitum, attapulgite, meerschaum, zeolite etc.; The composite of supported nano zinc oxide; Nano zine oxide load on carrier is even, dispersive property good, have narrow grain size distributes; Solve nanoparticle preferably and reunited and stability problem, had effects such as stronger photocatalytic degradation, uvioresistant.
Document 1: Kang Suyuan, Lu Shixiang, Xu Wenguo; Liu Shifeng, week is silver-colored. sepiolite supported nano zinc oxide photocatalysis material and preparation method thereof. and application number: Crinis Carbonisatus such as 200810222209.7. Kang Suyuan are understood a kind of sepiolite supported nano zinc oxide photocatalysis material, and its preparation method is with the meerschaum behind the hydrochloric acid activation; With zinc acetate mix homogeneously in anhydrous ethanol solvent; Ethanol solution with hydroxide joins in the above-mentioned mixed solution distilling under reduced pressure, drying then; At last 50～500 ℃ of roastings more than 1 hour, and be ground to less than 100 orders.
Document 2: Yao Chao, Liu Min, Chen Zhigang; Li Weimin, Hu Xiaoli, Liu Jianping. a kind of method for preparing attapulgite/zinc oxide nanometer composite material. application number: the superfine Crinis Carbonisatus of 200810243654. Yao is understood a kind of method for preparing attapulgite/zinc oxide nanometer composite material; At first prepare the nano-attapulgite dispersion liquid; Add zinc salt solution and carbonate aqueous solution then, mixed serum filters, Cake Wash, drying, roasting.The nano composite material load of preparing is even, dispersive property good and tangible photocatalytic degradation performance is arranged.
Document 3: Gong Zhaozhuo; Zheng Shuilin, Lv Fangli, Shen Hongling; Sun Zhiming. the preparation of nano zine oxide one calcined kaolin composite. Chinese powder technology; 2010,16:58-60. Gong Zhao Zhuo etc. at the surperficial clad nano zinc oxide of calcined kaolin, have prepared a kind of inorganic composite type uvioresistant material with the hydrolysis sedimentation method.The zinc oxide covering amount is 8% (7%).
Document 4: Du Yiting. original position synthesizing nano-silver, zinc oxide between montmorillonite layer. Technical Colleges Of Guilin's master thesis; 2008. original position synthesizing nano-silver, zinc oxide between kaolinite, montmorillonite layer. Du Yiting is after zinc nitrate intercalation Montmorillonitum finishes; After the excessive urea of adding grinds together a little under drying condition; Put into and make its burning under the hot environment, unnecessary urea burning volatilization is prepared into zinc oxide/Montmorillonitum intercalated compound at last.
Document 5: Lin Zhang, Zhang Zhen, Yang Lefu; Ma Zengxin, Lin Jingdong, Liao Daiwei. the anti-microbial property research of nano zine oxide and load zeolite. chemical research and application; 2009,2l:1309-1313. Lin Zhang etc. add the zeolite of the feed grade of different quality in the aqueous solution of zinc nitrate, the aqueous solution of dropping sodium and sodium carbonate under stirring; Filtration washing, drying the back of sieving is sintering temperature roasting 1 h with 300 ℃, has prepared zeolite-nano zine oxide complex; Can better inhibited the growth of mycete, reach the effect of antibacterial and mouldproof.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, purposes and the method for using of a kind of loaded nano zinc oxide as the ablactational baby pig anti-diarrhea agents are provided.
The loaded nano zinc oxide is as the purposes of ablactational baby pig anti-diarrhea agents.
Described loaded nano zinc oxide is to be carrier with Kaolin or Montmorillonitum or attapulgite or meerschaum or zeolite, the composite of supported nano zinc oxide.
In the composite of described supported nano zinc oxide, the weight percent content of zinc oxide is 10 ~ 50%.
The loaded nano zinc oxide as the method for using of ablactational baby pig anti-diarrhea agents is: add in the ablactational baby pig feedstuff in the dosage of zinc by 160～800 mg/kg.
The loaded nano zinc oxide that uses in the invention can be the commercial goods, also can be according to prior art for preparing, and its technology of preparing is well-known.
The present invention has the following advantages:
(1) nano zine oxide of the present invention load on carrier is even, dispersive property good, have narrow grain size distributes, and has solved nanoparticle preferably and has reunited and stability problem.。
(2) the loaded nano zinc oxide is fed and can be reduced the disassociation of gastric acid to zinc oxide in piglet, realizes the slow release of zinc oxide in animal intestinal, makes more zinc oxide arrive intestinal with molecular conformation, performance diarrhea effect.And supported nano zinc oxide can be avoided feedstuff constant and trace quantity mineral substance element absorption, metabolism, sedimentary interference.
(3) add 60～800 mg/kg (in zinc) loaded nano zinc oxide in the daily ration and can significantly reduce the diarrhea of weaned piglets rate, improve daily gain, improve the intestinal mucosa form; Protection intestinal mucosal barrier, and the glow of piglet fur have been avoided the toxic and side effects of high zinc daily ration to pig; Its action effect has surpassed use high dose common zinc oxide (2500 ~ 3000 mg/kg; In zinc), greatly reduce zinc oxide dosage, reduced feces zinc and drained and environmental pollution.
The specific embodiment
The loaded nano zinc oxide is as the purposes of ablactational baby pig anti-diarrhea agents.
Described loaded nano zinc oxide is to be carrier with Kaolin or Montmorillonitum or attapulgite or meerschaum or zeolite, the composite of supported nano zinc oxide.
In the composite of described supported nano zinc oxide, the weight percent content of zinc oxide is 10 ~ 50%.
The loaded nano zinc oxide as the method for using of ablactational baby pig anti-diarrhea agents is: add in the ablactational baby pig feedstuff in the dosage of zinc by 160～800 mg/kg.
The loaded nano zinc oxide that uses in the invention can be the commercial goods, also can be according to prior art for preparing, and its technology of preparing is well-known.
The present invention combines following instance to be further described.
EXAMPLE l
According to document (Du Yiting. original position synthesizing nano-silver, zinc oxide between montmorillonite layer. Technical Colleges Of Guilin's master thesis; 2008.) method prepare nano-ZnO/Montmorillonitum intercalated compound; By weight percentage, the content of zinc oxide in nano composite material is 10%.
The zinc oxide rate of dissociation in the in-vitro simulated stomach of table 1 (pH value 2.5)
| ? | Common zinc oxide | The loaded nano zinc oxide |
| The zinc oxide rate of dissociation, % | 55.2±6.3 | 9.2±1.2 |
Visible by table 1, montmorillonite-loaded nano zine oxide zinc oxide rate of dissociation in in-vitro simulated stomach significantly is lower than common zinc oxide.
Select for use 96 (5.7 ± 0.2 kg) 21 ages in days " Du * length * big " /> ablactational baby pig to be divided into 3 groups at random: (1) matched group, the basal diet of feeding; (2) zinc oxide group is added 2500 mg/kg zinc oxide (in zinc) in the basal diet; (3) loaded nano zinc oxide group is added 160 mg/kg loaded nano zinc oxide (in zinc) in the basal diet.Every group of 4 repetitions, each repeats 8 piglets, experimental periods 14 d.(result) result shows 1) compare with matched group, add 160 mg/kg loaded nano zinc oxide and improved ablactational baby pig daily gain 8.52 % (P < 0.05), reduced diarrhea rate 75.63% (P < 0.05), not remarkable with 2500 mgkg zinc oxide group differences.2) compare loaded nano zinc oxide group piglet 28 ages in days and 35 age in days height of naps improve 15.63% respectively (P < 0.05) and 13.25% (P < 0.05) with matched group; The crypts degree of depth reduces by 16.85% respectively (P < 0.05) and 12.35 % (P>0.05); Height of naps/crypts degree of depth improves 34.25 % (P < 0.05) and 24.63 % (P < 0.05) respectively, plasma D-lactic acid reduces by 31.23% respectively (P < 0.05) and 24.62 % (P 0.05); The DAO activity reduces by 28.95 % (P < 0.05) and 22.38 % (P < 0.05) respectively.Each index difference not significantly (P>0.05) between 2500 mg/kg zinc oxide groups and the 160 mg/kg loaded nano zinc oxide groups.Results suggest is added 160 mg/kg loaded nano zinc oxide and can be improved daily gain in the ablactational baby pig daily ration, reduce diarrhea rate, improves the intestinal mucosa form, reduces intestinal permeability, and its effect is suitable with interpolation 2500 mg/kg common zinc oxides.
Embodiment 2
According to document (Gong Zhaozhuo, Zheng Shuilin, Lv Fangli; Shen Hongling; Sun Zhiming. the preparation of nano zine oxide one calcined kaolin composite. Chinese powder technology, 2010, method 16:58-60) prepares the composite of kaoline loaded with nano zinc oxide; By weight percentage, the content of zinc oxide in nano composite material is 20%.
The zinc oxide rate of dissociation in the in-vitro simulated stomach of table 1 (pH value 2.5)
| ? | Common zinc oxide | The loaded nano zinc oxide |
| The zinc oxide rate of dissociation, % | 55.2±6.3 | 11.6±1.7 |
Visible by table 1, kaoline loaded with nano zinc oxide zinc oxide rate of dissociation in in-vitro simulated stomach significantly is lower than common zinc oxide.
The result of the test of in the ablactational baby pig daily ration, adding 2500 mg/kg (in zinc) zinc oxide and 300 mg/kg (in zinc) loaded nano zinc oxide shows; 300 mg/kg loaded nano zinc oxide can reduce diarrhea of weaned piglets rate 65.2%; Improve daily gain 7.6%, its effect slightly is superior to adding 2500 mg/kg common zinc oxides.
Embodiment 3
According to document (Lin Zhang, Zhang Zhen, Yang Lefu; Ma Zengxin, Lin Jingdong, Liao Daiwei. the anti-microbial property research of nano zine oxide and load zeolite. chemical research and application; 2009; 2l:1309-1313.) method prepare zeolite-nano zine oxide composite, by weight percentage, the content of zinc oxide in nano composite material is 30%.
The mensuration result of the zinc oxide rate of dissociation in the in-vitro simulated stomach (pH value 2.5) shows that zeolite-nano zine oxide composite zinc oxide rate of dissociation in in-vitro simulated stomach is 12.5 ± 2.1, significantly is lower than common zinc oxide 55.2 ± 6.3.
The result of the test of in the ablactational baby pig daily ration, adding 3000 mg/kg (in zinc) zinc oxide and 500 mg/kg (in zinc) loaded nano zinc oxide shows; 500 mg/kg loaded nano zinc oxide can reduce diarrhea of weaned piglets rate 82.6%; Improve daily gain 7.2%; Improve jejunum villi height 17.5%, reduce the crypts degree of depth 16.8 %, its effect slightly is superior to adding 3000 mg/kg common zinc oxides.
Embodiment 4
According to document (Yao Chao; Liu Min, Chen Zhigang, Li Weimin; Hu Xiaoli; Liu Jianping. a kind of method for preparing attapulgite/zinc oxide nanometer composite material. application number: method 200810243654.) prepares attapulgite/zinc oxide nanometer composite material, and by weight percentage, the content of zinc oxide in nano composite material is 40%.
The result of the test of in the ablactational baby pig daily ration, adding 2800 mg/kg (in zinc) zinc oxide and 600mg/kg (in zinc) loaded nano zinc oxide shows; 600 mg/kg loaded nano zinc oxide can reduce diarrhea of weaned piglets rate 65.8% (P < 0.05); Improve daily gain 5.4% (P < 0.05), plasma D-lactic acid and DAO activity reduce by 28.5% respectively (P < 0.05) and 26.4% (P < 0.05).2800 mg/>kg (in zinc) zinc oxide and 600mg/kg (in zinc) loaded nano zinc oxide group These parameters do not have significant difference.
Embodiment 5
According to document (Kang Suyuan; Lu Shixiang; Xu Wenguo, Liu Shifeng, week is silver-colored. sepiolite supported nano zinc oxide photocatalysis material and preparation method thereof. application number: method 200810222209.7.) prepares the sepiolite supported nano zinc oxide composite; By weight percentage, the content of zinc oxide in nano composite material is 50%.
The result of the test of in the ablactational baby pig daily ration, adding 3000 mg/kg (in zinc) zinc oxide and 800mg/kg (in zinc) loaded nano zinc oxide shows; 800 mg/kg loaded nano zinc oxide can reduce diarrhea of weaned piglets rate 72.6% (P < 0.05); Improve daily gain 6.1% (P < 0.05), plasma D-lactic acid and DAO activity reduce by 32.5% respectively (P < 0.05) and 31.2% (P < 0.05).2800 mg/>kg (in zinc) zinc oxide and 800mg/kg (in zinc) loaded nano zinc oxide group These parameters do not have significant difference.
Claims (4)
1. the loaded nano zinc oxide is as the purposes of ablactational baby pig anti-diarrhea agents.
2. a kind of loaded nano zinc oxide according to claim 1 is as the anti-diarrhea purposes of ablactational baby pig; It is characterized in that; Described loaded nano zinc oxide is to be carrier with Kaolin or Montmorillonitum or attapulgite or meerschaum or zeolite, the composite of supported nano zinc oxide.
3. a kind of loaded nano zinc oxide according to claim 1 is characterized in that as the purposes of ablactational baby pig anti-diarrhea agents in the composite of described supported nano zinc oxide, the weight percent content of zinc oxide is 10 ~ 50%.
4. a loaded nano zinc oxide as claimed in claim 1 is characterized in that: add in the ablactational baby pig feedstuff in the dosage of zinc by 160～800 mg/kg as the method for using of ablactational baby pig anti-diarrhea agents.
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| CN104546908A (en) * | 2015-01-28 | 2015-04-29 | 成都乾坤动物药业有限公司 | Pharmaceutical composition as well as preparation method and application thereof |
| CN105920111A (en) * | 2016-05-27 | 2016-09-07 | 湖南泰谷生物兽药有限公司 | Anti-diarrhea feed additive and preparation method thereof |
| CN106135696A (en) * | 2016-07-02 | 2016-11-23 | 浙江大学 | CS ZnO is as the application of intestine of young pigs mucosal immunity reinforcing agent |
| CN106186042A (en) * | 2016-07-15 | 2016-12-07 | 东莞市民益生物科技有限公司 | A kind of feedstuff three-dimensional multistage hole nano zine oxide and preparation method thereof |
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| CN108887479A (en) * | 2018-06-14 | 2018-11-27 | 华南农业大学 | L-Aspartic acid zinc promotes animal intestinal tract development in preparation and alleviates the application in intestinal tract injury preparation |
| CN109349431A (en) * | 2018-12-21 | 2019-02-19 | 美泰克（天津）矿物有限公司 | A kind of preparation method of anti-diarrhea additive for feed for porkets |
| CN109674815A (en) * | 2019-02-02 | 2019-04-26 | 浙江大学 | A kind of weanling pig intestinal mucosa renovation agent |
| CN111067917A (en) * | 2019-12-10 | 2020-04-28 | 北京桃古图生物科技有限公司 | Composite material loaded with nano zinc oxide and preparation method thereof |
| CN112167455A (en) * | 2020-10-14 | 2021-01-05 | 四川省旺达饲料有限公司 | Green additive composition for weaned piglets, preparation method and application method |
| CN115708542A (en) * | 2022-09-27 | 2023-02-24 | 乐山师范学院 | Zinc oxide-loaded bamboo fiber compound and preparation method thereof |
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| CN105920111A (en) * | 2016-05-27 | 2016-09-07 | 湖南泰谷生物兽药有限公司 | Anti-diarrhea feed additive and preparation method thereof |
| CN106135696B (en) * | 2016-07-02 | 2019-11-05 | 浙江大学 | Application of the CS-ZnO as intestine of young pigs mucosal immunity reinforcing agent |
| CN106135696A (en) * | 2016-07-02 | 2016-11-23 | 浙江大学 | CS ZnO is as the application of intestine of young pigs mucosal immunity reinforcing agent |
| CN106186042A (en) * | 2016-07-15 | 2016-12-07 | 东莞市民益生物科技有限公司 | A kind of feedstuff three-dimensional multistage hole nano zine oxide and preparation method thereof |
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| CN108887479A (en) * | 2018-06-14 | 2018-11-27 | 华南农业大学 | L-Aspartic acid zinc promotes animal intestinal tract development in preparation and alleviates the application in intestinal tract injury preparation |
| CN109349431B (en) * | 2018-12-21 | 2021-12-17 | 美泰克（天津）矿物有限公司 | Preparation method of diarrhea-preventing suckling pig feed additive |
| CN109349431A (en) * | 2018-12-21 | 2019-02-19 | 美泰克（天津）矿物有限公司 | A kind of preparation method of anti-diarrhea additive for feed for porkets |
| CN109674815A (en) * | 2019-02-02 | 2019-04-26 | 浙江大学 | A kind of weanling pig intestinal mucosa renovation agent |
| CN111067917A (en) * | 2019-12-10 | 2020-04-28 | 北京桃古图生物科技有限公司 | Composite material loaded with nano zinc oxide and preparation method thereof |
| CN112167455A (en) * | 2020-10-14 | 2021-01-05 | 四川省旺达饲料有限公司 | Green additive composition for weaned piglets, preparation method and application method |
| WO2024063664A1 (en) | 2022-09-23 | 2024-03-28 | Beointech D.O.O. Beograd | Ultrasonic low temperature synthesis of an advanced multifunctional additive for application in animal feed production |
| CN115708542A (en) * | 2022-09-27 | 2023-02-24 | 乐山师范学院 | Zinc oxide-loaded bamboo fiber compound and preparation method thereof |
| CN115708542B (en) * | 2022-09-27 | 2024-07-02 | 乐山师范学院 | Zinc oxide-loaded bamboo fiber compound and preparation method thereof |
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Application publication date: 20120201 |