CN105920111A - Anti-diarrhea feed additive and preparation method thereof - Google Patents
Anti-diarrhea feed additive and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of feed, and particularly provides an anti-diarrhea feed additive. The feed additive contains the following components: an intestinal mucosa protecting agent, a synergistic factor, a radix astragali extract, a flos lonicerae extract, a radix scutellariae extract, a fructus forsythiae extract, zeolite powder and an aluminosilicate carrier. The invention also relates to a preparation method of the anti-diarrhea feed additive. The anti-diarrhea feed additive controls the diarrhea of a piglet in aspects of killing or isolating pathogenic microorganisms, repairing an injured intestinal mucosa, multiplying intestinal beneficial bacterial colonies, and the like; meanwhile, the anti-diarrhea feed additive can also improve the disease resistance of the piglet, and is a green, non-reactive and residue-free feed additive.
Description
Technical field
The present invention relates to field of fodder, specifically, relate to a kind of diarrhea feed additive and preparation side thereof
Method.
Background technology
Piglet diarrhea is the disease of a kind of multi-factor comprehensive, occurs mainly in the 1-3 monthly age.There is sickness rate high,
The feature that mortality rate is high, is one of several big disease carrying out tremendous economic loss to cultivation industrial belt.Due to this stage
Piglet to there is resistance poor, the digestive system development feature such as not exclusively, easily cause antibacterial, virus and post
Infested etc. infection and diarrhoea occurs, another change in weather, jump, the stress such as transport and dyspepsia are also
Cause the reason of diarrhoea.If not giving the most reasonably treatment, the state of an illness can transfer chronic diarrhea further to,
Affecting the speed of growth of piglet, another severe patient then can lethal because of electrolyte disturbance, dehydration etc. be died.
Present stage to the treatment of piglet diarrhea mainly based on chemicals, although also have certain curative effect, but
Less effective on the whole, reason be chemicals after killing pathogenic microorganism, also press down simultaneously and killed intestinal
Interior probiotics, thus increase the weight of diarrhoea and affect piglet growth speed.Therefore, the present invention is by piglet abdomen
Rush down pathogeny and the analysis of the undesirable reason of clinical therapeutic efficacy and research, it is thus achieved that one treats piglet abdomen
The new approaches rushed down, i.e. after killing pathogen, repair intestinal mucosa simultaneously, thus guide and activate intestinal
Group restores balance again, finally provides lasting protection for intestinal, the adverse effect of piglet diarrhea is dropped to
Minimum point, reduces the economic loss brought because of disease, the most indirectly adds the economic benefit of cultivation.
Summary of the invention
In order to realize the purpose of the present invention, the invention provides a kind of anti-diarrhea feed additive and preparation side thereof
Method, fundamentally solves the problem that antibacterial drug therapy piglet diarrhea is undesirable.
Present invention firstly provides a kind of diarrhea feed additive, described diarrhea feed additive contain with
The component of lower weight portion: intestinal mucosa protective agent 4～10 parts, synergistic factor 8～17 parts, Radix Astragali extract 8～
17 parts, Flos Lonicerae extract 3～7 parts, Radix Scutellariae extract 3～7 parts, Fructus Forsythiae extract 7～15 parts, boiling
Stone powder 15～22 parts, aluminosilicate carrier adds to 100 parts；
Preferably, containing the component of following weight portion: intestinal mucosa protective agent 6～9 parts, synergistic factor 9～
16 parts, Radix Astragali extract 9～15 parts, Flos Lonicerae extract 4～6 parts, Radix Scutellariae extract 4～6 parts, even
Sticking up extract 8～12 parts, zeolite powder 17～21 parts, aluminosilicate carrier adds to 100 parts；
It is highly preferred that the component containing following weight portion: intestinal mucosa protective agent 8 parts, synergistic factor 15 parts,
Radix Astragali extract 10 parts, Flos Lonicerae extract 5 parts, Radix Scutellariae extract 5 parts, Fructus Forsythiae extract 10 parts,
Zeolite powder 20 parts, aluminosilicate carrier adds to 100 parts.
Further, described intestinal mucosa protective agent is zinc oxide, nano zine oxide, tannic acid, alkali formula nitric acid
The mixture of one or more in bismuth, bismuth subcarbonate；Preferably, described intestinal mucosa protective agent is for receiving
Rice zinc oxide.Intestinal mucosa protective agent is plant extract or chemosynthesis material, can directly or indirectly (solve
After separating out zinc or bismuth ion) and gastric mucosa protein binding, it is coated on gastrointestinal mucosa surface and shields, from
And isolate the damage to intestinal of pathogen and toxin.
Further, the one during described synergistic factor is oligofructose, oligomeric xylose, oligomeric isomaltose
Or several mixture；Preferably, described synergistic factor is oligomeric isomaltose.Synergistic factor is through enzyme water
The oligosaccharide obtained after solution, has stomach juice-resistant and the effect of digestion resistant enzyme, therefore can safety gastrointestinal tract；Make
Probiotics can be made again to become dominant microflora and indirectly press down by the fermented utilization of the probiotics in intestinal for carbon source
The growth of pathogen processed, provides long-acting, lasting protection for intestinal.
Further, described Radix Astragali extract is leguminous plant Radix Astagali Astragalus
Membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsial or Radix Astragali
The extraction that the dry root of Astragalus membranaceus (Fisch.) Bge. is processed into through water boiling and precipitation with ethanol method
Thing.Concrete preparation method is: take the Radix Astragali, boiling 2～3 times, 1.5～2 hours for the first time, for the second time
1.5～2 hours, collecting decoction, it is concentrated into appropriate, adds ethanol and make alcohol content reach 70%～75%, stand, take
Supernatant, decompression recycling ethanol, concentrated solution is spray-dried, to obtain final product.
Preferably, in Radix Astragali extract, the content of astragalus polysaccharides is not less than 70%.Its major function is for promoting body
Immunity.
Further, described Flos Lonicerae extract is caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb.
Dry flower or the extract be processed into through alcohol reflux of the flower just opened of band.Concrete preparation method is:
Extracting honeysuckle, adds alcohol reflux 2～3 times, the most each 1～1.5 hour, united extraction liquid, decompression
It is concentrated into appropriate, adds ethanol and make alcohol content reach 60%～65%, stand, take supernatant, decompression recycling ethanol,
Concentrated solution is spray-dried, and to obtain final product.
Preferably, Flos Lonicerae extract Content of Chlorogenic Acid is not less than 3.5%.Its function is heat-clearing and toxic substances removing, dredges
Wind dispels the heat.Clinically for toxic-heat and blood stasis.
Further, described Radix Scutellariae extract is labiate Radix Scutellariae Scutellaria baicalensis
The extract that the dry root of Georgi is processed into through water boiling and precipitation with ethanol method.Concrete preparation method is: take Radix Scutellariae,
Boiling 2 times, 1～1.5 hour for the first time, 1～1.5 hour for the second time, collecting decoction, it is concentrated into appropriate,
Decocting liquid is with hydrochloric acid solution regulation pH value to highly acid, and 80 DEG C of insulations, standing, filtration, precipitate adds suitable quantity of water
Stirring evenly, with sodium hydroxide solution regulation pH value to neutral, add ethanol, be stirred to dissolve, filter, filtrate adds
Salt acid for adjusting pH value is to highly acid, and 60 DEG C of insulations, standing, filtration, precipitation is dense by suitable quantity of water and difference successively
It is neutral that the ethanol of degree is washed till pH value, waves most ethanol, drying under reduced pressure, to obtain final product.
Preferably, in Radix Scutellariae extract, content of baicalin is not less than 85%.Its function is heat clearing and damp drying, pathogenic fire purging solution
Poison, hemostasis, antiabortive.Damp and hot for gastrointestinal clinically, dysentery.
Further, described Fructus Forsythiae extract is Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.)
The extract that the dry fruit of Vahl is processed into through water boiling and precipitation with ethanol method.Concrete preparation method is: take Fructus Forsythiae,
Pulverizing, boiling 3～4 times, the most each 1～1.5 hour, filter, merging filtrate, filtrate decompression is dense
Being reduced to appropriate, let cool, add ethanol, stir evenly, stand, filter, filtrate decompression returns ethanol, and concentrated solution sprays
Mist is dried, and to obtain final product.
Preferably, in Fructus Forsythiae extract, Determination of forsythin is not less than 0.5%.Its function is heat-clearing and toxic substances removing, Sweeling-eliminating medicine powder
Knot.Generate heat for epidemic febrile disease clinically, skin ulcer general edema with yellowish skin poison.
Further, described aluminosilicate carrier is bentonite, meerschaum, Pulvis Talci, montmorillonite, nanometer illiteracy
The mixture of one or more in de-stone；Preferably, described aluminosilicate carrier is nanometer Montmorillonitum.Silicon
Aluminate carrier has huge surface area due to its special crystal structure, therefore has excellent absorption and make
With, the toxin produced in adsorbable intestinal, thus the damaging action to intestinal of alleviating diarrhoea.
Weight portion of the present invention can be the unit of weights well known in the art such as μ g, mg, g, kg, it is possible to
To be its multiple, such as 1/10,1/100,10 times, 100 times etc..
Present invention also offers the preparation method of a kind of above-mentioned diarrhea feed additive, comprise the steps:
A. the temperature and relative humidity preparing in environment is set: temperature is as 15 DEG C～30 DEG C, and relative humidity is
15%～30%；
B., after design temperature and relative humidity, it is prepared as follows:
B1. the Flos Lonicerae extract of full dose and the Radix Scutellariae extract of full dose, mix homogeneously are taken；
B2. toward the mixture obtained by step B1 adds the intestinal mucosa protective agent of full dose, mix homogeneously；
B3. toward the astragalus extraction being sequentially added into the zeolite powder of full dose, full dose in the mixture obtained by step B2
Thing, the aluminosilicate carrier of half amount, the Fructus Forsythiae extract of full dose, the synergistic factor of full dose, remaining sial
Hydrochlorate carrier, mix homogeneously, standby；
B4. after in, inspection is qualified, subpackage, packaging,.
Preferably, described temperature is preferably 20 DEG C～25 DEG C, and relative humidity is preferably 18%～25%.
It is highly preferred that described temperature is 25 DEG C, relative humidity is 20%.
The beneficial effects of the present invention is:
A kind of feed additive provided by the present invention, overcomes traditional antibacterials preventing and treating piglet diarrhea
Shortcoming, has the beneficial effect that (one) can activate and breed intestinal beneficial flora, makes profitable strain become in intestinal
Dominant microflora, thus competitive inhibition growth of pathogenic bacteria；(2) pathogenic microorganism can be killed and block cause of disease
The toxin that bacterium the produces damaging action to intestinal, so that damaged intestine mucosa is quickly repaired；(3) energy
Improve the specific immunity of piglet, indirectly promote the resistance against diseases of body, thus reduce secondary infection.This
Invention thoroughly solves the problem that antibacterial drug therapy piglet diarrhea is undesirable, also provides one for veterinary clinic
The medication reference for the treatment of piglet diarrhea.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.Embodiment is not noted
Bright concrete technology or condition person, according to the technology described by the document in this area or condition, or according to product
Product description is carried out.Agents useful for same or instrument unreceipted production firm person, be and can be purchased by regular channel
Available conventional products.
Embodiment 1 Radix Astragali extract, Flos Lonicerae extract, Radix Scutellariae extract and the preparation of Fructus Forsythiae extract
Radix Astragali extract preparation method is: take the dry root of leguminous plant Radix Astagali, boiling 2 times,
8 times amount soak by water 1.5 hours for the first time, for the second time 6 times amount soak by water 1.5 hours, collecting decoction is dense
It is reduced to appropriate, adds ethanol and make alcohol content reach 72%, stand 10 hours, take supernatant, decompression recycling ethanol,
Concentrated solution is spray-dried, and the content of the astragalus polysaccharides in the Radix Astragali extract prepared is 70%.
The preparation method of Flos Lonicerae extract is: take the dry flower of caprifoliaceae plant Radix Ophiopogonis, the ethanol adding 15%
Reflux, extract, 2 times, the most each 1 hour, united extraction liquid, being evaporated to relative density was 1.15～1.18
The clear paste of (60 DEG C), adds ethanol and makes alcohol content reach 63%, stand 22 hours, take supernatant, recovered under reduced pressure
Ethanol, concentrated solution is spray-dried, and the content of the Flos Lonicerae extract Content of Chlorogenic Acid prepared is 3.5%.
The preparation method of Radix Scutellariae extract is: take the dry root of labiate Radix Scutellariae, boiling 2 times,
8 times amount soak by water 1 hour, 6 times amount soak by water 1 hour, collecting decoction for the second time, it is concentrated into appropriate,
Decocting liquid 2mol/L hydrochloric acid solution regulation pH value is incubated 30 minutes to 1.0～2.0,80 DEG C, stands 12 little
Time, filtering, precipitate adds suitable quantity of water and stirs evenly, and with 40% sodium hydroxide solution regulation pH value to 7.0, adds
Amount ethanol, is stirred to dissolve, and filters, filtrate salt adding acid for adjusting pH value to 1.0～2.0,60 DEG C insulation 30
Minute, standing, filter, precipitation is washed till pH value to 7.0 with the ethanol of suitable quantity of water and variable concentrations successively, waves
Ethanol to the greatest extent, drying under reduced pressure, in prepared Radix Scutellariae extract, content of baicalin is 85.0%.
The preparation method of Fructus Forsythiae extract is: takes the dry fruit of Oleaceae plants Fructus Forsythiae, is ground into coarse powder,
Boiling 3 times, 1 hour for the first time, 1.5 hours for the second time, 1 hour for the third time, filters, merges
Filtrate, filtrate is evaporated to, in less than 60 DEG C, the clear paste that relative density is 1.10～1.20 (room temperatures), puts
Cold, add 4 times amount ethanol, stir evenly, stand 2 hours, filter, filtrate decompression returns ethanol, and concentrated solution sprays
Mist is dried, and in the Fructus Forsythiae extract prepared, Determination of forsythin is 0.5%.
Embodiment 2 Radix Astragali extract, Flos Lonicerae extract, Radix Scutellariae extract and the preparation of Fructus Forsythiae extract
Radix Astragali extract preparation method is: take the dry root of Radix Astragali, boiling 2 times, for the first time 8
Times amount soak by water 2 hours, for the second time 6 times amount soak by water 2 hours, collecting decoction, be concentrated into appropriate, add
Entering ethanol makes alcohol content reach 75%, stands 12 hours, takes supernatant, decompression recycling ethanol, and concentrated solution is sprayed
Being dried, in the Radix Astragali extract prepared, the content of astragalus polysaccharides is 75.0%.
The preparation method of Flos Lonicerae extract is: take the flower that caprifoliaceae plant Radix Ophiopogonis band is just opened, the ethanol adding 15%
Reflux, extract, 2 times, the most each 1 hour, united extraction liquid, being evaporated to relative density was 1.15～1.18
The clear paste of (60 DEG C), adds ethanol and makes alcohol content reach 65%, stand 24 hours, take supernatant, reduce pressure back
Receiving ethanol, concentrated solution is spray-dried, and the Flos Lonicerae extract Content of Chlorogenic Acid prepared is 4.0%.
The preparation method of Radix Scutellariae extract is: take the dry root of labiate Radix Scutellariae, boiling 2 times, first
Secondary 8 times amount soak by water 1.5 hours, for the second time 6 times amount soak by water 1.5 hours, collecting decoction, be concentrated into appropriate,
Decocting liquid 2mol/L hydrochloric acid solution regulation pH value is incubated 30 minutes to 1.0～2.0,80 DEG C, stands 12 little
Time, filtering, precipitate adds suitable quantity of water and stirs evenly, and with 40% sodium hydroxide solution regulation pH value to 7.0, adds
Amount ethanol, is stirred to dissolve, and filters, filtrate salt adding acid for adjusting pH value to 1.0～2.0,60 DEG C insulation 30
Minute, standing, filter, precipitation is washed till pH value to 7.0 with the ethanol of suitable quantity of water and variable concentrations successively, waves
Ethanol to the greatest extent, drying under reduced pressure, in prepared Radix Scutellariae extract, content of baicalin is 88.0%.
The preparation method of Fructus Forsythiae extract is: takes the dry fruit of Oleaceae plants Fructus Forsythiae, is ground into coarse powder, adds
Soak by water 3 times, each 1.5 hours, filters, and merging filtrate, filtrate is evaporated to phase in less than 60 DEG C
It is the clear paste of 1.10～1.20 (room temperatures) to density, lets cool, add 4 times amount ethanol, stir evenly, stand 2
Hour, filtering, filtrate decompression returns ethanol, and concentrated solution is spray-dried, phillyrin in the Fructus Forsythiae extract prepared
Content is 0.65%.
Embodiment 3
The present embodiment provides a kind of diarrhea feed additive, containing tannic acid 10kg in every 100kg, oligofructose
8kg, Radix Astragali extract 17kg, Flos Lonicerae extract 7kg, Radix Scutellariae extract 7kg, Fructus Forsythiae extract 15kg,
Zeolite powder 15kg, Pulvis Talci 21kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 1.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 25 DEG C, and relative humidity is 20%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the tannic acid of full dose, mix homogeneously；Sequentially add complete
The zeolite powder of amount, the Radix Astragali extract of full dose, the Pulvis Talci of half amount, the Fructus Forsythiae extract of full dose, full dose
Oligofructose, remaining Pulvis Talci, mix homogeneously, standby；After middle inspection is qualified, subpackage, packaging,.
Embodiment 4
The present embodiment provides a kind of diarrhea feed additive, containing basic bismuth nitrate 6kg in every 100kg, low
Xylan 15kg, Radix Astragali extract 8kg, Flos Lonicerae extract 3kg, Radix Scutellariae extract 8kg, Fructus Forsythiae extracts
Thing 12kg, zeolite powder 22kg, bentonite 26kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use real
Execute the extract prepared by example 2.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 20 DEG C, and relative humidity is 30%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the basic bismuth nitrate of full dose, mix homogeneously；The most successively
Add the zeolite powder of full dose, the Radix Astragali extract of full dose, the bentonite of half amount, the Fructus Forsythiae extract of full dose,
The oligomeric xylose of full dose, remaining bentonite, mix homogeneously, standby；After middle inspection is qualified, subpackage, packaging,
?.
Embodiment 5
The present embodiment provides a kind of diarrhea feed additive, containing nano zine oxide 4kg in every 100kg, low
IMO 17kg, Radix Astragali extract 10kg, Flos Lonicerae extract 5kg, Radix Scutellariae extract 5kg, even
Stick up extract 7kg, zeolite powder 20kg, bentonite 10kg, montmorillonite 2 2kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 2.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 15 DEG C, and relative humidity is 26%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the nano zine oxide of full dose, mix homogeneously；The most successively
Add the zeolite powder of full dose, the Radix Astragali extract of full dose, the bentonite of half amount, the montmorillonite of half amount, full dose
Fructus Forsythiae extract, the oligomeric isomaltose of full dose, remaining bentonite and montmorillonite, mix homogeneously, standby
With；After middle inspection is qualified, subpackage, packaging,.
Embodiment 6
The present embodiment provides a kind of diarrhea feed additive, containing zinc oxide 5kg in every 100kg, oligomeric fruit
Sugar 5kg, oligomeric isomaltose 11kg, Radix Astragali extract 15kg, Flos Lonicerae extract 4kg, Radix Scutellariae extracts
Thing 6kg, Fructus Forsythiae extract 10kg, zeolite powder 17kg, montmorillonite 2 7kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 1.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 30 DEG C, and relative humidity is 15%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the zinc oxide of full dose, mix homogeneously；Sequentially add
The zeolite powder of full dose, the Radix Astragali extract of full dose, the montmorillonite of half amount, the Fructus Forsythiae extract of full dose, full dose
Oligofructose and oligomeric isomaltose, remaining montmorillonite, mix homogeneously, standby；After middle inspection is qualified,
Subpackage, packaging,.
Embodiment 7
The present embodiment provides a kind of diarrhea feed additive, containing nano zine oxide 5kg in every 100kg, tan
Acid 4kg, oligomeric isomaltose 9kg, Radix Astragali extract 9kg, Flos Lonicerae extract 6kg, Radix Scutellariae extract
7kg, Fructus Forsythiae extract 15kg, zeolite powder 15kg, montmorillonite 30kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 2.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 18 DEG C, and relative humidity is 25%,；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add nano zine oxide and the tannic acid of full dose, mix homogeneously；
Sequentially add the zeolite powder of full dose, the Radix Astragali extract of full dose, the partly montmorillonite of amount, the Fructus Forsythiae of full dose carry
Take thing, the oligomeric isomaltose of full dose, remaining montmorillonite, mix homogeneously, standby；After middle inspection is qualified,
Subpackage, packaging,.
Embodiment 8
The present embodiment provides a kind of diarrhea feed additive, containing nano zine oxide 5kg in every 100kg, low
Xylan 15kg, Radix Astragali extract 9kg, Flos Lonicerae extract 6kg, Radix Scutellariae extract 3kg, Fructus Forsythiae extracts
Thing 8kg, zeolite powder 21kg, meerschaum 10kg, montmorillonite 2 3kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 1.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 25 DEG C, and relative humidity is 18%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the nano zine oxide of full dose, mix homogeneously；The most successively
Add the zeolite powder of full dose, the Radix Astragali extract of full dose, the meerschaum of half amount, the montmorillonite of half amount, full dose
Fructus Forsythiae extract, the oligomeric xylose of full dose, remaining meerschaum and montmorillonite, mix homogeneously, standby；
After middle inspection is qualified, subpackage, packaging,.
Embodiment 9
The present embodiment provides a kind of diarrhea feed additive, containing nano zine oxide 8kg in every 100kg, low
Polyfructose. 10kg, oligomeric xylose 5kg, Radix Astragali extract 10kg, Flos Lonicerae extract 5kg, Radix Scutellariae extracts
Thing 5kg, Fructus Forsythiae extract 10kg, zeolite powder 17kg, nanometer Montmorillonitum 30kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 2.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 25 DEG C, and relative humidity is 15%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the nano zine oxide of full dose, mix homogeneously；The most successively
Add the Fructus Forsythiae extraction of the zeolite powder of full dose, the Radix Astragali extract of full dose, the nanometer Montmorillonitum of half amount, full dose
Thing, the oligofructose of full dose and oligomeric xylose, remaining nanometer Montmorillonitum, mix homogeneously, standby；Middle inspection
After qualified, subpackage, packaging,.
Embodiment 10
The present embodiment provides a kind of diarrhea feed additive, containing nano zine oxide 8kg in every 100kg, low
Polyfructose. 10kg, oligomeric xylose 5kg, Radix Astragali extract 10kg, Flos Lonicerae extract 5kg, Radix Scutellariae extracts
Thing 5kg, Fructus Forsythiae extract 10kg, zeolite powder 17kg, meerschaum 30kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 2.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 25 DEG C, and relative humidity is 20%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the nano zine oxide of full dose, mix homogeneously；The most successively
Add the zeolite powder of full dose, the Radix Astragali extract of full dose, the meerschaum of half amount, the Fructus Forsythiae extract of full dose,
The oligofructose of full dose and oligomeric xylose, remaining meerschaum, mix homogeneously, standby；After middle inspection is qualified,
Subpackage, packaging,.
Embodiment 11
The present embodiment provides a kind of diarrhea feed additive, containing nano zine oxide 8kg in every 100kg, low
IMO 15kg, Radix Astragali extract 10kg, Flos Lonicerae extract 5kg, Radix Scutellariae extract 5kg, Fructus Forsythiae
Extract 10kg, zeolite powder 20kg, nanometer Montmorillonitum 27kg.
Radix Astragali extract in the present embodiment, Flos Lonicerae extract, Radix Scutellariae extract and Fructus Forsythiae extract use to be implemented
Extract prepared by example 2.
The preparation method of the diarrhea feed additive described in the present embodiment specifically includes following steps:
(1) temperature and humidity preparing in environment is set: temperature is as 25 DEG C, and relative humidity is 20%；
(2), after design temperature and relative humidity, carry out as follows: take full dose Flos Lonicerae extract and
The Radix Scutellariae extract of full dose, mix homogeneously；Add the nano zine oxide of full dose, mix homogeneously；The most successively
Add the Fructus Forsythiae extraction of the zeolite powder of full dose, the Radix Astragali extract of full dose, the nanometer Montmorillonitum of half amount, full dose
Thing, the oligomeric isomaltose of full dose, remaining nanometer Montmorillonitum, mix homogeneously, standby；After middle inspection is qualified,
Subpackage, packaging,.
Test example 1 draws moist test
1, test objective: investigate in the present invention and easily draw the impact on preparation method of the wet each component.
2, test method
2.1 take dry tool plug glass weighing botle (external diameter is 50mm, a height of 15mm), put the previous day in test
In suitable growth cabinet (scalable humiture), accurately weighed weight (m1)。
2.2 take component sample in right amount, are laid in weighing botle, and test sample thickness is about 1mm, accurately weighed
Weight (m2)。
2.3 is uncovered by weighing botle, and with bottle cap with being placed in 5min, 15min, 30min under the conditions of above-mentioned constant temperature and humidity.
2.4 build weighing botle lid, accurately weighed weight (m3), and it is calculated as follows percentage weight increase (η):
2.5 draw moist feature description and draw defining of moist weightening finish, are shown in Table 1.
Table 1 draw moist feature description with draw moist weightening finish define table
| Draw wet weightening finish | Feature description |
| Absorb enough water and divide formation liquid | Deliquescence |
| η >=15% | Great draw moist |
| 2%≤η ＜ 15% | Have draw moist |
| 0.2%≤η ＜ 2% | Slightly draw moist |
| η ＜ 0.2% | Nothing or moist almost without drawing |
2.6 each component draw moist result of the test be shown in Table 2, table 3, table 4.
Radix Astragali extract, Flos Lonicerae extract and Fructus Forsythiae extract use the extract of embodiment 2 preparation.
Result of the test shows, easily draw wet each component high temperature, high humidity prepare environment draws moist extremely strong, very
Easily absorb the moisture in air and cannot be uniformly dispersed；In low humidity, low temperature environment then wet almost without drawing
Property.Therefore preparation process needs to control the temperature and humidity of environment.
The each component of table 2 draws moist percentage weight increase table (RH=65%, T=30 DEG C)
| Component | 5min | 15min | 30min |
| Radix Astragali extract | 5.4% | 9.6% | 17.1% |
| Flos Lonicerae extract | 4.8% | 7.5% | 15.5% |
| Fructus Forsythiae extract | 4.2% | 6.3% | 10.7% |
| Oligomeric isomaltose | 7.2% | 10.4% | 18.3% |
The each component of table 3 draws moist percentage weight increase table (RH=30%, T=20 DEG C)
| Component | 5min | 15min | 30min |
| Radix Astragali extract | 0.12% | 0.12% | 0.13% |
| Flos Lonicerae extract | 0.10% | 0.10% | 0.10% |
| Fructus Forsythiae extract | 0.09% | 0.09% | 0.10% |
| Oligomeric isomaltose | 0.15% | 0.15% | 0.16% |
The each component of table 4 draws moist percentage weight increase table (RH=15%, T=25 DEG C)
| Component | 5min | 15min | 30min |
| Radix Astragali extract | 0.10% | 0.10% | 0.12% |
| Flos Lonicerae extract | 0.08% | 0.09% | 0.09% |
| Fructus Forsythiae extract | 0.08% | 0.08% | 0.08% |
| Oligomeric isomaltose | 0.12% | 0.12% | 0.15% |
Test example 2 stability test
1, test objective: investigate the stability of a kind of diarrhea feed additive provided by the present invention.
2, test method: this test is as a example by 3 batches of products that embodiment 11 prepares, with reference to the Ministry of Agriculture's " veterinary drug
Stability test guideline " require to have carried out accelerated test, in temperature 25 DEG C ± 2 DEG C, relative humidity 60%
The condition of ± 10% is investigated, and carries respectively at the 1st, 2,3,6 character detecting product the end of month and the Radix Astragali
Take the content of thing, Flos Lonicerae extract, Radix Scutellariae extract, Fructus Forsythiae extract.
3, result of the test and analysis: accelerated test the results are shown in Table 5, and result shows, under adding gentle humidified condition
Investigating to 6 the end of month, there is not significant change in the character of said preparation, remaining each index all meets quality standard
Requirement, therefore, said preparation is still stable in the environment of high temperature and high humidity.
Table 5 accelerated test result
Test example 3 clinical trial
1, test objective
In order to verify the drug effect of a kind of diarrhea feed additive that the present invention provides.The present invention implements in this test
The diarrhea feed additive that example 11 prepares carries out therapeutic effect test to piglet diarrhea respectively with control drug.
2, test material
2.1 trial drug
Blank group: oresol (commercially available)
Drug control group: oresol (commercially available)+SHUANGHUANGLIAN KOUFUYE (animal pharmaceutical factory, Chongqing, lot number
12120301)
Medication therapy groups: the feed additive that oresol (commercially available)+embodiment of the present invention 11 prepares (is criticized
Numbers 12110501)
2.2 test packets
Randomly select 400 example in February, 2013～in the February, the 2015 piglet diarrhea case on pig farm, Yongzhou is
Object of study, and use the method for table of random number to be classified as blank group, drug control group and medicine
Treatment group.Ill piglet was 1～3 monthly ages, and disease time is 1～5 day.Enter the ill piglet clinical condition of group
Shape is typical and meets into group requirement, and blank group is 50 examples, and drug control group and medication therapy groups are often organized respectively
175 example disease pigs, compare at aspects such as body weight, age in days and disease times, and no significant difference, having can
Compare property.
2.3 therapeutic scheme
Therapeutic scheme is shown in Table 6.
Table 6 each test group therapeutic scheme
2.4 efficacy assessment standard
Curing: clinical symptom disappearance after medication, as having loose bowels, diarrhoea stops, and spirit takes a turn for the better, and growth recovery is normal；
Effective: clinical symptom relief after medication, as having loose bowels, diarrhoea stops, spirit improvement etc.；
Invalid: before and after medication, clinical symptoms is unchanged, even there is the phenomenon increased the weight of.
2.5 statistical analysiss and process
All data carry out statistical analysis, and measurement data uses t inspection, and enumeration data compares employing X2Inspection,
P ＜ 0.05 has statistical significance for difference.
3, result of the test
The results are shown in Table 7.Find through comparative study, drug control group total effective rate (cure+effectively) 142
(81.14%) significantly lower than the 168 (96.0%) of medication therapy groups, and difference has statistical significance
(P ＜ 0.05).It addition, the body weight of drug control group piglet does not only increase, the body weight of more piglets reduces；
And the body weight of medication therapy groups piglet all has increase in various degree.Therefore, one provided by the present invention is raised
It is a kind of preferably preparation that feed additives is used for controlling piglet diarrhea, both safe and effective.
Table 7 clinical therapeutic efficacy relative analysis
Except the diarrhea feed additive of embodiment 11, the diarrhea feedstuff that other embodiments of the invention prepare
Additive and by the diarrhea feed additive obtained by the formula of the present invention and preparation method, is respectively provided with
The medicine stability similar to embodiment 11 and clinical drug effect, the diarrhea feed additive obtained by the present invention
Not only control the diarrhoea problem of piglet, also improve the resistance against diseases of piglet simultaneously.
Although, the present invention is described in detail the most with a general description of the specific embodiments,
But on the basis of the present invention, can make some modifications or improvements it, this is to those skilled in the art
Obviously.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all
Belong to the scope of protection of present invention.
Claims (10)
1. a diarrhea feed additive; it is characterized in that; component containing following weight portion: intestinal mucosa protective agent 4～10 parts; synergistic factor 8～17 parts, Radix Astragali extract 8～17 parts, Flos Lonicerae extract 3～7 parts; Radix Scutellariae extract 3～7 parts; Fructus Forsythiae extract 7～15 parts, zeolite powder 15～22 parts, aluminosilicate carrier adds to 100 parts；
Preferably, containing the component of following weight portion: intestinal mucosa protective agent 6～9 parts, synergistic factor 9～16 parts; Radix Astragali extract 9～15 parts, Flos Lonicerae extract 4～6 parts, Radix Scutellariae extract 4～6 parts; Fructus Forsythiae extract 8～12 parts, zeolite powder 17～21 parts, aluminosilicate carrier adds to 100 parts；
It is highly preferred that the component containing following weight portion: intestinal mucosa protective agent 8 parts, synergistic factor 15 parts, Radix Astragali extract 10 parts, Flos Lonicerae extract 5 parts, Radix Scutellariae extract 5 parts, Fructus Forsythiae extract 10 parts, zeolite powder 20 parts, aluminosilicate carrier adds to 100 parts.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: described intestinal mucosa protective agent is the mixture of one or more in zinc oxide, nano zine oxide, tannic acid, basic bismuth nitrate, bismuth subcarbonate；Described intestinal protective agent is preferably nano zine oxide.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: described synergistic factor is the mixture of one or more in oligofructose, oligomeric xylose, oligomeric isomaltose；Described synergistic factor is preferably oligomeric isomaltose.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: described Radix Astragali extract is the extract that the dry root of leguminous plant Radix Astagali or Radix Astragali is processed into through water boiling and precipitation with ethanol method；Preferably, in described Radix Astragali extract, the content of astragalus polysaccharides is not less than 70%.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: the extract that the flower that described Flos Lonicerae extract is the dry flower of caprifoliaceae plant Radix Ophiopogonis or band is just opened is processed into through alcohol reflux；Preferably, described Flos Lonicerae extract Content of Chlorogenic Acid is not less than 3.5%.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: described Radix Scutellariae extract is the extract that the dry root of labiate Radix Scutellariae is processed into through water boiling and precipitation with ethanol method；Preferably, in described Radix Scutellariae extract, content of baicalin is not less than 85%.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: described Fructus Forsythiae extract is the extract that the dry fruit of Oleaceae plants Fructus Forsythiae is processed into through water boiling and precipitation with ethanol method；Preferably, in described Fructus Forsythiae extract, Determination of forsythin is not less than 0.5%.
A kind of diarrhea feed additive the most according to claim 1, it is characterised in that: described aluminosilicate carrier is the mixture of one or more in bentonite, meerschaum, Pulvis Talci, montmorillonite, nanometer Montmorillonitum；Described aluminosilicate carrier is preferably nanometer Montmorillonitum.
9. the preparation method of a diarrhea feed additive according to any one of claim 1 to 8, it is characterised in that comprise the steps:
A. the temperature and relative humidity preparing in environment is set: temperature is as 15 DEG C～30 DEG C, and relative humidity is 15%～30%；
B., after design temperature and relative humidity, it is prepared as follows:
B1. the Flos Lonicerae extract of full dose and the Radix Scutellariae extract of full dose, mix homogeneously are taken；
B2. toward the mixture obtained by step B1 adds the intestinal mucosa protective agent of full dose, mix homogeneously；
B3. toward the mixture obtained by step B2 is sequentially added into the zeolite powder of full dose, the Radix Astragali extract of full dose, the aluminosilicate carrier of half amount, the Fructus Forsythiae extract of full dose, the synergistic factor of full dose, remaining aluminosilicate carrier, mix homogeneously, standby；
B4. after in, inspection is qualified, subpackage, packaging,.
10. according to the preparation method of the diarrhea feed additive described in claim 9, it is characterised in that: described temperature is preferably 20 DEG C～25 DEG C, and relative humidity is preferably 18%～25%；It is highly preferred that described temperature is 25 DEG C, relative humidity is 20%.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106387435A (en) * | 2016-10-20 | 2017-02-15 | 中粮饲料有限公司 | Feed additive, and application thereof, as well as feed |
| CN107348146A (en) * | 2017-07-28 | 2017-11-17 | 青岛农业大学 | Natural and multi-functional feed addictive |
| CN110613054A (en) * | 2019-09-17 | 2019-12-27 | 中国农业大学 | Chinese herbal medicine additive for lactating sows and application thereof |
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|---|---|---|---|---|
| CN102335196A (en) * | 2011-10-25 | 2012-02-01 | 浙江大学 | Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method |
| CN104435265A (en) * | 2013-09-16 | 2015-03-25 | 保龄宝生物股份有限公司 | Oral liquid for preventing and treating piglet diarrhea |
| CN104546908A (en) * | 2015-01-28 | 2015-04-29 | 成都乾坤动物药业有限公司 | Pharmaceutical composition as well as preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102335196A (en) * | 2011-10-25 | 2012-02-01 | 浙江大学 | Use of supported nano zinc oxide as anti-diarrhea agent for weaned pigs and using method |
| CN104435265A (en) * | 2013-09-16 | 2015-03-25 | 保龄宝生物股份有限公司 | Oral liquid for preventing and treating piglet diarrhea |
| CN104546908A (en) * | 2015-01-28 | 2015-04-29 | 成都乾坤动物药业有限公司 | Pharmaceutical composition as well as preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106387435A (en) * | 2016-10-20 | 2017-02-15 | 中粮饲料有限公司 | Feed additive, and application thereof, as well as feed |
| CN107348146A (en) * | 2017-07-28 | 2017-11-17 | 青岛农业大学 | Natural and multi-functional feed addictive |
| CN110613054A (en) * | 2019-09-17 | 2019-12-27 | 中国农业大学 | Chinese herbal medicine additive for lactating sows and application thereof |
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