CN102641439B - Compound propolis composition for curing chicken infectivity throat bronchitis and preparation method thereof - Google Patents
Compound propolis composition for curing chicken infectivity throat bronchitis and preparation method thereof Download PDFInfo
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Abstract
A compound propolis composition for curing chicken infectivity throat bronchitis and a preparation method thereof relate to the field of animal medicines. The compound propolis composition is formed by mixing and matching the following ingredients by parts of weight: 15-35 parts of propolis, 15-45 parts of folium mori, 10-35 parts of fructus forsythiae, 15-35 parts of reed rhizome, 10-35 parts of trichosanthes kirilowii maxim, 10-35 parts of radix ophiopogonis, 10-35 parts of radix paeoniae alba, 15-35 parts of burdock and 10-40 parts of isatis root. The compound propolis composition has the advantages of being reasonable in formula, simple in preparation, free of toxic and side effect, free of pollution, free of drug residue, free of drug resistance, high in superfine grinding and biological utilization rate and obvious in treatment. Clinical tests show that the compound propolis composition has special effects on curing chicken infectivity throat bronchitis.
Description
Technical field
The present invention relates to treat bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof, belong to the animal field of medicaments, particularly a kind of bronchitic compound bee-glue composition of the avian infectious larynx for the treatment of and preparation method thereof that is specifically designed to.
Background technology
Avian infectious larynx bronchitis is a kind of acute, the contact upper respiratory infectious disease caused by avian infectious larynx bronchitis virus.The chicken of various ages and kind all can infect, and it is characterized in that the exudate that dyspnea, cough and expectoration contain blood sample.Visible throat, tunica mucosa tracheae swelling, hemorrhage and rotten to the corn while cuing open inspection.Primary disease is propagated fast, and mortality rate is generally between 10%-30%.This disease all can occur throughout the year, and cold season autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is herpesvirus, and virus can be survived more than 1 year under dry environment.Under cryogenic conditions, the time-to-live is long.This disease almost spreads all over the world all poultry country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs ban use of as Ministry of Agriculture such as ribavirin, amantadines.
Therefore researching and developing a kind of bronchitic drug residue free of avian infectious larynx, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the bronchitic compound bee-glue composition of the avian infectious larynx of effective treatment of drug residue and preparation method thereof.
For achieving the above object, implementation of the present invention is as follows: a kind of bronchitic compound bee-glue composition of avian infectious larynx for the treatment of, by following component by weight mixed preparing form: propolis 15-35 part, Folium Mori 15-45 part, Fructus Forsythiae 10-35 part, Rhizoma Phragmitis 15-35 part, Fructus Trichosanthis 10-35 part, Radix Ophiopogonis 10-35 part, Radix Paeoniae Alba 10-35 part, Fructus Arctii 15-35 part, Radix Isatidis 10-40 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 30 parts, Folium Mori, 25 parts of Fructus Forsythiaes, 25 parts of Rhizoma Phragmitiss, 25 parts of Fructus Trichosanthis, 25 parts of Radix Ophiopogonis, 25 parts of the Radix Paeoniae Albas, 25 parts of Fructus Arctiis, 25 parts of Radix Isatidis.
A kind of preparation method for the treatment of the bronchitic compound bee-glue composition of avian infectious larynx, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Folium Mori 15-45 part, Fructus Forsythiae 10-35 part, Rhizoma Phragmitis 15-35 part, mix 5-10 minute to even;
(3) take by weight Fructus Trichosanthis 10-35 part, Radix Ophiopogonis 10-35 part, Radix Paeoniae Alba 10-35 part, Fructus Arctii 15-35 part, Radix Isatidis 10-40 part, mix 5-10 minute to evenly;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, have anti-inflammation, pain relieving only overworked, promote tissue regeneration, improve the function of immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Folium Mori: sweet, bitter, cold, return lung, Liver Channel, there is the function of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving; Curing mainly anemopyretic cold, cough due to lung-heat, conjunctival congestion sheds tears etc.
Fructus Forsythiae: bitter, cold, return lung, the heart, small intestine meridian, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Rhizoma Phragmitis: sweet, cold, attach to the lung and stomach meridians, there is the function of clearing away heat and promoting production of body fluid, preventing or arresting vomiting, diuresis; Cure mainly that interior-heat is thirsty, lung abscess, gastropyretic vomiting, the puckery pain of pyretic stranguria etc.
Fructus Trichosanthis: sweet, bitter, cold, return lung, stomach, large intestine channel, there is the function of removing heat-phlegm, promoting the circulation of QI eliminating stagnation, moistening dryness for relaxing bowels; Cure mainly cough due to lung-heat, chest and diaphragm pain, acute mastitis, feces drying etc.
Radix Ophiopogonis: bitter, sweet, cold, return lung, the heart, stomach warp, there is the function that YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire; Cure mainly yin asthenia generating intrinsic heat, dryness of the lung dry cough, dryness of the intestine constipation etc.
The Radix Paeoniae Alba: bitter, acid, be slightly cold, return liver, spleen channel, there is the suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.
Fructus Arctii: hot, bitter, cold, attach to the lung and stomach meridians, there is the function of dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat; Cure mainly affection due to external wind and heat, cough and asthma, laryngopharynx swelling and pain, carbuncle sore tumefacting virus etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for the bronchitic pathogenic microorganism of avian infectious larynx and clinical symptoms and pathological change, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this nine flavors Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, to treating avian infectious larynx bronchitis, specially good effect is arranged, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof for the treatment of: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts, Folium Mori, 100 parts of Fructus Forsythiaes, 150 parts of Rhizoma Phragmitiss, mix 5-10 minute to even;
(3) take by weight 100 parts of Fructus Trichosanthis, 100 parts of Radix Ophiopogonis, 100 parts of the Radix Paeoniae Albas, 150 parts of Fructus Arctiis, 100 parts of Radix Isatidis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof for the treatment of: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 300 parts, Folium Mori, 150 parts of Fructus Forsythiaes, 250 parts of Rhizoma Phragmitiss, mix 5-10 minute to even;
(3) take by weight 200 parts of Fructus Trichosanthis, 200 parts of Radix Ophiopogonis, 200 parts of the Radix Paeoniae Albas, 250 parts of Fructus Arctiis, 250 parts of Radix Isatidis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof for the treatment of: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 450 parts, Folium Mori, 350 parts of Fructus Forsythiaes, 350 parts of Rhizoma Phragmitiss, mix 5-10 minute to even;
(3) take by weight 350 parts of Fructus Trichosanthis, 350 parts of Radix Ophiopogonis, 350 parts of the Radix Paeoniae Albas, 350 parts of Fructus Arctiis, 400 parts of Radix Isatidis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 150-250 age in days, body weight at 1.8kg-3.0kg, and Laboratory Diagnosed is the bronchitic ill laying hen of avian infectious larynx.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; The blank group is left intact, and the medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 250kg feeds, and drinking-water 400kg, is used in conjunction 3-5 day at every day 2-3 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Result (testing the 8th day) when following table is the experiment end.
Table is that the present invention and other medicines are treated the applicable cases contrast of the bronchitic field of avian infectious larynx:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 26.6 | 32.2 | 41.2 |
| II | The HOUYANJING SAN group | 8.3 | 79.0 | 12.7 |
| III | Chinese medicine composition of the present invention | 6.5 | 87.7 | 5.8 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P<0.01) with the HOUYANJING SAN group aspect cure rate.
Above-mentionedly with reference to embodiment, this is treated to the detailed description that bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof carries out; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. a treatment avian infectious larynx bronchitic compound bee-glue composition, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Folium Mori 15-45 part, Fructus Forsythiae 10-35 part, Rhizoma Phragmitis 15-35 part, Fructus Trichosanthis 10-35 part, Radix Ophiopogonis 10-35 part, Radix Paeoniae Alba 10-35 part, Fructus Arctii 15-35 part, Radix Isatidis 10-40 part.
2. the bronchitic compound bee-glue composition of the avian infectious larynx for the treatment of according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts, Folium Mori, 25 parts of Fructus Forsythiaes, 25 parts of Rhizoma Phragmitiss, 25 parts of Fructus Trichosanthis, 25 parts of Radix Ophiopogonis, 25 parts of the Radix Paeoniae Albas, 25 parts of Fructus Arctiis, 25 parts of Radix Isatidis.
3. the preparation method of the bronchitic compound bee-glue composition of the avian infectious larynx for the treatment of according to claim 1 is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Folium Mori 15-45 part, Fructus Forsythiae 10-35 part, Rhizoma Phragmitis 15-35 part, mix 5-10 minute to even;
(3) take by weight Fructus Trichosanthis 10-35 part, Radix Ophiopogonis 10-35 part, Radix Paeoniae Alba 10-35 part, Fructus Arctii 15-35 part, Radix Isatidis 10-40 part, mix 5-10 minute to evenly;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210133693.2A CN102641439B (en) | 2012-05-03 | 2012-05-03 | Compound propolis composition for curing chicken infectivity throat bronchitis and preparation method thereof |
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| CN201210133693.2A CN102641439B (en) | 2012-05-03 | 2012-05-03 | Compound propolis composition for curing chicken infectivity throat bronchitis and preparation method thereof |
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| CN102641439B true CN102641439B (en) | 2014-01-01 |
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| CN106071146A (en) * | 2016-06-22 | 2016-11-09 | 丁大喜 | A kind of pharmaceutical composition for treating sheep bronchitis |
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