CN105685484A - Compound eucalyptus oil composition for preventing and treating livestock viral respiratory disease and preparing method thereof - Google Patents
Compound eucalyptus oil composition for preventing and treating livestock viral respiratory disease and preparing method thereof Download PDFInfo
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Abstract
The invention relates to a compound eucalyptus oil composition for preventing and treating the livestock viral respiratory disease.The compound eucalyptus oil composition is prepared by mixing, by weight, 15-55 parts of eucalyptus oil, 15-45 parts of mint oil, 15-35 parts of great burdock achene, 15-45 parts of codonopsis pilosula, 10-50 parts of licorice roots, 10-50 parts of portulaca oleracea, 15-35 parts of elecampane inula roots, 10-40 parts of pseudo-ginseng, 15-45 parts of anhwei barberry roots and 15-55 parts of Chinese dates.The composition has the advantages that the composition is reasonable, preparation is simple, the composition is free of toxic and side effects, pollution, drug resides and drug resistance, is ground in a superfine mode, and is high in bioavailability and remarkable in curative effect, and clinic proves that the composition has special effects of preventing and treating the livestock viral respiratory disease.
Description
Technical field
The present invention relates to the compound recipe eucalyptus oil composition and method of making the same of preventing and treating animal viral respiratory tract disease, belong to animal feed additive field, particularly to a kind of compound recipe eucalyptus oil composition and method of making the same being specifically designed to preventing and treating animal viral respiratory tract disease。
Background technology
Animal viral respiratory tract disease is by multiple virus mixed infection, the coefficient result of many factors。Main manifestations is respiratory symptom and nervous symptoms, organa parenchymatosum's inflammation, hemorrhage, downright bad etc.。Primary disease sickness rate and case fatality rate are all significantly high, all can occur throughout the year, are one of principal diseases endangering livestock and poultry breeding industry。
This disease almost spreads over all livestock and poultry cultivation countries of the world, is widely distributed。At present, treat this disease and be most commonly used that Chinese medicine and Western medicine。Western medical treatment mainly based on sterilizing and anti-virus, the medicine aid in cough-relieving, reduce phlegm, relievining asthma such as carbetapentane citrate, Bisolvon etc.。And in Western medicine antiviral drugs such as ribavirin, amantadine etc. due to its serious toxic and side effects and curative effect poor, the Ministry of Agriculture prohibits the use of。Antimicrobial drug and antitussive and antiasthmatic drugs thing are owing to its toxic and side effects is strong, be easily generated the problem such as drug resistance and drug residue, and clinical practice is very limited。Chinese medicine is owing to its prescription is unreasonable or simply simple pulverizing, and particle diameter is excessive, and drug release is relatively slow, causes that its bioavailability is relatively low, and clinical effectiveness is not as。
Therefore research and develop and a kind of prevent and treat the having no side effect of animal viral respiratory tract disease, drug residue free, the efficacious additive for fodder produced that has no drug resistance are one of this field scientific research technical staff new problem anxious to be resolved。
Summary of the invention
It is an object of the invention to overcome above-mentioned weak point, it is provided that a kind of reasonable recipe, preparation is simple, micronizing, bioavailability high, effect substantially, have no side effect, have no drug resistance and the compound recipe eucalyptus oil composition and method of making the same effectively preventing and treating animal viral respiratory tract disease of drug residue。
Implementation of the present invention is as follows for achieving the above object: a kind of compound recipe eucalyptus oil compositions preventing and treating animal viral respiratory tract disease, following components mixed preparing by weight form: eucalyptus oil 15-55 part, Oleum menthae 15-45 part, Fructus Arctii 15-35 part, Radix Codonopsis 15-45 part, Radix Glycyrrhizae 10-50 part, Herba Portulacae 10-50 part, Radix Inulae 15-35 part, Radix Notoginseng 10-40 part, Radix Berberidis 15-45 part, Fructus Jujubae 15-55 part。
Described various component optimum ratio amount is: eucalyptus oil 35 parts, Oleum menthae 30 parts, Fructus Arctii 25 parts, Radix Codonopsis 30 parts, 30 parts of Radix Glycyrrhizae, Herba Portulacae 30 parts, Radix Inulae 25 parts, Radix Notoginseng 25 parts, Radix Berberidis 30 parts, 35 parts of Fructus Jujubae。
The preparation method of a kind of compound recipe eucalyptus oil compositions preventing and treating animal viral respiratory tract disease, carries out as follows:
(1) by the composition in prescription, except eucalyptus oil and Oleum menthae, 700 mesh sieves are crossed after micronizing respectively；
(2) weigh Fructus Arctii 15-35 part, Radix Codonopsis 15-45 part, Radix Glycyrrhizae 10-50 part, Herba Portulacae 10-50 part by weight, mix 5-10 minute to uniformly；
(3) weigh Radix Inulae 15-35 part, Radix Notoginseng 10-40 part, Radix Berberidis 15-45 part, Fructus Jujubae 15-55 part by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares and eucalyptus oil and Oleum menthae, continue mixing 10-15 minute to uniform。
The medicinal property of each component is as follows:
Eucalyptus oil: bitter, warm, returns liver, lung, liver, spleen channel, has function refrigerant, pain relieving；Cure mainly traumatic injury, congestion swells and ache。
Herba Menthae: pungent, cool, returns liver, lung meridian, has the function of heat radiation, dispelling wind, diaphoresis, dissipating depression of QI；Cure mainly affection due to external wind and heat, laryngopharynx swelling and pain, conjunctival congestion, tripe is swollen, dyspepsia does not disappear。
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function；Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning。
Fructus Arctii: cold, bitter, pungent, attaches to the lung and stomach meridians, and has the function of dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat；Cure mainly affection due to external wind and heat, cough and asthma, laryngopharynx swelling and pain, carbuncle sore tumefacting virus etc.。
Radix Codonopsis: sweet, flat, returns lung, spleen channel, has the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting；Cure mainly weakness of the spleen and stomach, eat diarrhoea less, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy are hung down de-etc.。
Herba Portulacae: sour, cold, returns liver, large intestine channel, has the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery；Cure mainly pyretic toxicity dysentery, skin ulcer general edema with yellowish skin poison, pyretic stranguria hematuria, have blood in stool, snake bite and insect sting etc.。
Radix Inulae: bitter, pungent, warm, returns liver, spleen channel, has invigorating the spleen and regulating the stomach, promoting the circulation of QI to relieve pain, antiabortive function；Cure mainly weight, frequent fetal movement etc. after stagnation of QI abdominal distention, stomachache, vomiting, dysentery。
Radix Berberidis: bitter, cold, returns liver, large intestine, stomach warp, has the function of heat clearing and damp drying, eliminating fire and detoxication；Cure mainly hematodiarrhoea have blood in stool, jaundice due to damp-heat, difficulty in urination, conjunctival congestion and swelling pain etc.。
Radix Notoginseng: hardship sweet, micro-, temperature, returns liver, stomach warp, has the function of reducing swelling and alleviating pain, dissipating blood stasis hemostasis；Cure mainly have blood in stool, epistaxis, haematemesis, traumatic hemorrhage, traumatic injury blood stasis etc.。
Fructus Jujubae: sweet, warm, returns spleen, stomach warp, has the function of invigorating the spleen and replenishing QI, nourishing blood and preventing abortion；Cure mainly weakness of the spleen and stomach, diarrhea due to hypofunction of the spleen, deficiency of both QI and blood, deficiency of body fluid etc.。
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the paathogenic factor of animal viral respiratory tract disease, clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease。
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more uniform；Said composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant。Present invention Chinese veterinarian's traditional theory, preferably go out this Ten Herbs, and make them form feed additive according to optimum ratio, clinical practice proves, preventing and treating animal viral respiratory tract disease there is specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, be effectively ensured the healthy of people。
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound recipe eucalyptus oil composition and method of making the same preventing and treating animal viral respiratory tract disease: carry out as follows: (every part by 10g)
(1) by the composition in prescription, except eucalyptus oil and Oleum menthae, 700 mesh sieves are crossed after micronizing respectively；
(2) weigh Fructus Arctii 150 parts, Radix Codonopsis 150 parts, 100 parts of Radix Glycyrrhizae, Herba Portulacae 100 parts by weight, mix 5-10 minute to uniformly；
(3) weigh Radix Inulae 150 parts, Radix Notoginseng 100 parts, Radix Berberidis 150 parts, 150 parts of Fructus Jujubae by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares and eucalyptus oil 150 parts and Oleum menthae 150 parts, continue mixing 10-15 minute to uniform。
Embodiment 2
A kind of compound recipe eucalyptus oil composition and method of making the same preventing and treating animal viral respiratory tract disease: carry out as follows: (every part by 10g)
(1) by the composition in prescription, except eucalyptus oil and Oleum menthae, 700 mesh sieves are crossed after micronizing respectively；
(2) weigh Fructus Arctii 250 parts, Radix Codonopsis 300 parts, 300 parts of Radix Glycyrrhizae, Herba Portulacae 300 parts by weight, mix 5-10 minute to uniformly；
(3) weigh Radix Inulae 250 parts, Radix Notoginseng 250 parts, Radix Berberidis 300 parts, 350 parts of Fructus Jujubae by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares and eucalyptus oil 350 parts and Oleum menthae 300 parts, continue mixing 10-15 minute to uniform。
Embodiment 3
A kind of compound recipe eucalyptus oil composition and method of making the same preventing and treating animal viral respiratory tract disease: carry out as follows: (every part by 10g)
(1) by the composition in prescription, except eucalyptus oil and Oleum menthae, 700 mesh sieves are crossed after micronizing respectively；
(2) weigh Fructus Arctii 350 parts, Radix Codonopsis 450 parts, 500 parts of Radix Glycyrrhizae, Herba Portulacae 500 parts by weight, mix 5-10 minute to uniformly；
(3) weigh Radix Inulae 350 parts, Radix Notoginseng 400 parts, Radix Berberidis 450 parts, 550 parts of Fructus Jujubae by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares and eucalyptus oil 550 parts and Oleum menthae 450 parts, continue mixing 10-15 minute to uniform。
Clinical trial (one):
In the viral respiratory disease of domestic animal, the breeding of representational pig is tested with respiratory disorder syndrome。Clinical experiment animal selects 70-85 age in days, body weight at 35kg-40kg, and Laboratory Diagnosed is pig breeding and the syndromic ill pig of respiratory disorder。The isolation of ill pig individually being raised, feed complete feed, and be randomly divided into 3 groups, often group 30,3 groups of feeding environments are identical, and experiment carries out 7 days altogether；Blank group is left intact, and drug control group " antipyretic and antitoxic powder " (refer to " People's Republic of China's veterinary drug allusion quotation " 2000 editions two the 418th page) by specification uses treatment；Present composition group can by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill pig of feeding etc., day dose be: feed by the every 100g of the present invention, spice 200kg, every day 2-3 time, be used in conjunction 3-5 day；Reached the purpose for the treatment of disease by gastrointestinal absorption after oral。Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%。Table 1 below is result during experiment end。
Efficacy assessment standard:
Healing: spirit is normal, drinking-water of searching for food is normal, and breathing is normal, feces is normal, bouncing, and laboratory is not detected by pig breeding and respiratory disorder syndrome virus etc.。
Symptom is had: clinical symptoms is not improved and even increased the weight of during end。
Table 1 is present invention situation contrast syndromic with respiratory disorder with other medicines treatment pig breeding:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is had during end |
| Ⅰ | Blank group | 23.3 | 0 | 76.7 |
| Ⅱ | Antipyretic and antitoxic powder group | 10 | 60 | 30 |
| Ⅲ | Present composition group | 6.7 | 73.3 | 20 |
This clinical test results statistical analysis, present composition group and antipyretic and detoxicated scattered group of difference extremely notable (P < 0.01) compared with in cure rate。
Clinical trial (two):
In the viral respiratory disease of poultry, representational infectious bronchitis of chicken is tested。Clinical experiment animal selects 20 ages in days, body weight at 0.8kg-0.9kg, and Laboratory Diagnosed is the ill broiler of infectious bronchitis of chicken。The isolation of ill chicken individually being raised, feed complete feed, and be randomly divided into 3 groups, often group 100,3 groups of feeding environments are identical, and experimental period carries out 5 days altogether；Blank group is left intact, and drug control group institute's control drug " antipyretic and antitoxic powder " (refer to " People's Republic of China's veterinary drug allusion quotation " 2000 editions two the 418th page) is used according to an instruction treatment；Present composition group by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill poultry of feeding etc., day dose be: feed by the every 100g spice 220kg of the present invention, every day 2-3 time, be used in conjunction 3-5 day；Reached the purpose for the treatment of disease by gastrointestinal absorption after oral。Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%。Table 2 below is result during experiment end。
Efficacy assessment standard:
Curing: spirit is normal, drinking-water of searching for food is normal, and feces is normal, breathes normal etc.。Cuing open the histoorgans such as detector tube, bronchus, larynx normal, Experimental immunization fluoroscopic examination has no pathogenic microorganism avian infectious bronchitis virus etc.。
Symptom is had: clinical symptoms is not improved and even increased the weight of during end。
Table 2 is the Field information situation contrast of the present invention and other medicines treatment infectious bronchitis of chicken:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is had during end |
| Ⅰ | Blank group | 11 | 4 | 85 |
| Ⅱ | Antipyretic and antitoxic powder group | 7 | 80 | 13 |
| Ⅲ | Present composition group | 4 | 91 | 5 |
This clinical effectiveness statistical analysis, present composition group and antipyretic and detoxicated scattered group of difference extremely notable (P < 0.01) compared with in cure rate。
Safety testing (one):
Choose 20 age in days health broiler 60,30 days are fed according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2, during medication, healthy broiler does not have any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not notable that body weight increase compares difference with blank group (namely health is not administered group)。
Safety testing (two):
Choose 70 age in days health pig 10,30 days are fed according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2, during medication, experiment pig does not have any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not notable that body weight increase compares difference with blank group (namely health is not administered group)。
The above-mentioned detailed description composition and method of making the same of this preventing and treating animal viral respiratory tract disease carried out with reference to embodiment; it is illustrative rather than determinate; can according to restriction scope list several embodiments; therefore without departing from changing and modifications under present general inventive concept, should belong within protection scope of the present invention。
Claims (3)
1. prevent and treat a compound recipe eucalyptus oil compositions for animal viral respiratory tract disease, it is characterized in that being formed by following components mixed preparing by weight: eucalyptus oil 15-55 part, Oleum menthae 15-45 part, Fructus Arctii 15-35 part, Radix Codonopsis 15-45 part, Radix Glycyrrhizae 10-50 part, Herba Portulacae 10-50 part, Radix Inulae 15-35 part, Radix Notoginseng 10-40 part, Radix Berberidis 15-45 part, Fructus Jujubae 15-55 part。
2. the compound recipe eucalyptus oil compositions of preventing and treating animal viral respiratory tract disease according to claim 1, is characterized in that described various component optimum ratio amount is: eucalyptus oil 35 parts, Oleum menthae 30 parts, Fructus Arctii 25 parts, Radix Codonopsis 30 parts, 30 parts of Radix Glycyrrhizae, Herba Portulacae 30 parts, Radix Inulae 25 parts, Radix Notoginseng 25 parts, Radix Berberidis 30 parts, 35 parts of Fructus Jujubae。
3. a preparation method for the compound recipe eucalyptus oil compositions of preventing and treating animal viral respiratory tract disease according to claim 1 and 2, is characterized in that carrying out as follows:
(1) by the composition in prescription, except eucalyptus oil and Oleum menthae, 700 mesh sieves are crossed after micronizing respectively；
(2) weigh Fructus Arctii 15-35 part, Radix Codonopsis 15-45 part, Radix Glycyrrhizae 10-50 part, Herba Portulacae 10-50 part by weight, mix 5-10 minute to uniformly；
(3) weigh Radix Inulae 15-35 part, Radix Notoginseng 10-40 part, Radix Berberidis 15-45 part, Fructus Jujubae 15-55 part by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares and eucalyptus oil and Oleum menthae, continue mixing 10-15 minute to uniform。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106472839A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | A kind of compound microecological additive of preventing and treating pig winter respiratory tract disease and its using method |
| CN110664928A (en) * | 2019-10-23 | 2020-01-10 | 潍坊市华程生物科技有限公司 | Medicinal plant essential oil composition for preventing and treating poultry dryness pathogen invading lung syndrome |
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2016
- 2016-01-18 CN CN201610031389.5A patent/CN105685484A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106472839A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | A kind of compound microecological additive of preventing and treating pig winter respiratory tract disease and its using method |
| CN110664928A (en) * | 2019-10-23 | 2020-01-10 | 潍坊市华程生物科技有限公司 | Medicinal plant essential oil composition for preventing and treating poultry dryness pathogen invading lung syndrome |
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Application publication date: 20160622 |