CN103520674A - Pure traditional Chinese medicine composition for treatment of infectious bursa fabricius disease of poultry - Google Patents

Abstract

The invention relates to a pure traditional Chinese medicine composition for treatment of infectious bursa fabricius disease of poultry, and a specific preparation method of the pure traditional Chinese medicine composition comprises the following steps: (1) all components in the prescription are respectively superfinely crushed, then passes through a 700 mesh sieve, (2) weighing, by weight, 15-25 parts of cortex moutan, 15-35 parts of dried ginger, 15-25 parts of monkshood, 15-25 parts of radix aucklandiae and 15-25 parts of mangnolia officinalis, mixing for 5-10 minutes to even; (3) weighing, by weight, 15-30 parts of palm, 15-25 parts of circium japonicum, 15-35 parts of yam, 15-25 parts of licorice and 15-35 parts radix paeoniae alba, mixing for 5-10 minutes to even; (4), merging compositions prepared by the step (2) and (3), continuing to mix for 10-15 minutes to uniform. The beneficial effects of the pure traditional Chinese medicine composition are that: the prescription is reasonable, the preparation is simple, the pure traditional Chinese medicine composition has no toxic and side effect, no drug residue and no drug resistance, is superfinely crushed, and has high bioavailability and obvious curative effects, and clinic proofs that the pure traditional Chinese medicine composition has specific effects on treatment of the infectious bursa fabricius disease of the poultry.

Description

Pure Chinese medicine composition for the treatment of man poultry infectious bursal disease and preparation method thereof

Technical field

The present invention relates to pure Chinese medicine composition for the treatment of man poultry infectious bursal disease and preparation method thereof, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment man poultry infectious bursal disease and preparation method thereof.

Background technology

Family's poultry infectious bursal disease is that a kind of common transmittable being caused by poultry infectious bursal disease virus is sick, main infection 3-6 poultry in age in week, take clinically diarrhoea, arrange white thickness or water sample loose stool is feature, mortality rate is very high, very harmful to poultry.

The pathogen of primary disease is poultry infectious bursal disease virus, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine, but because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability to reduce, clinical effectiveness is not fine; And various antiviral Western medicine ban use of as ribavirin, the amantadine Deng， Ministry of Agriculture.

Therefore researching and developing a kind of specific medicament for the treatment of a poultry infectious bursal disease is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, the pure Chinese medicine composition of successful, the effective treatment man poultry infectious bursal disease that has no drug resistance and have no side effect and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease, by following component by weight mixed preparing form: Cortex Moutan 15-25 part, Rhizoma Zingiberis 15-35 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Aucklandiae 15-25 part, Cortex Magnoliae Officinalis 15-25 part, Petiolus Trachycarpi 15-30 part, Radix Cirsii Japonici 15-25 part, Rhizoma Dioscoreae 15-35 part, Radix Glycyrrhizae 15-25 part, Radix Paeoniae Alba 15-35 part.

Described various component optimum ratio amount is: 20 parts of Cortex Moutans, 25 parts of Rhizoma Zingiberiss, 20 parts of Radix Aconiti Lateralis Preparatas, 20 parts of the Radix Aucklandiae, 20 parts of Cortex Magnoliae Officinalis, 20 parts, Petiolus Trachycarpi, 20 parts of Radix Cirsii Japonicis, 25 parts of Rhizoma Dioscoreaes, 20 parts, Radix Glycyrrhizae, 25 parts of the Radix Paeoniae Albas.

A preparation method for the pure Chinese medicine composition of poultry infectious bursal disease, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Cortex Moutan 15-25 part, Rhizoma Zingiberis 15-35 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Aucklandiae 15-25 part, Cortex Magnoliae Officinalis 15-25 part, mix 5-10 minute to even;

(3) take by weight Petiolus Trachycarpi 15-30 part, Radix Cirsii Japonici 15-25 part, Rhizoma Dioscoreae 15-35 part, Radix Glycyrrhizae 15-25 part, Radix Paeoniae Alba 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Cortex Moutan: bitter, pungent, be slightly cold, return liver, the heart, kidney channel, there is the function of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Cure mainly maculae caused by violent heat pathogen, epistaxis, have blood in stool, hematuria, traumatic injury, carbuncle sore tumefacting virus etc.

Rhizoma Zingiberis: warm, pungent, return lung, urinary bladder channel, there is the function of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing; Cure mainly for anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough etc.

Radix Aconiti Lateralis Preparata: sweet, pungent, hot, return spleen, the heart, kidney channel, there is warming middle-JIAO except the function of cold, recuperating depleted YANG and rescuing the patient from collapse, expelling wind and removing dampness; Cure mainly that profuse sweating, YANG-depletion, extreme cold of the limbs, rheumatism, enterospasm, cold intestinal are had loose bowels, anemofrigid-damp arthralgia etc.

The Radix Aucklandiae: acrid, bitter, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, there is the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Cure mainly the gastrointestinal stagnation of QI, food stagnation tripe is swollen, weight, stomachache etc. after dysentery.

Cortex Magnoliae Officinalis: acrid, bitter, warm, return spleen, stomach, large intestine channel, there is the function of warming middle-JIAO dampness, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, removing mass eliminating stagnation; Cure mainly insufficiency of the spleen cold syndrome of the stomach, wound material, tripe abdominal distention and pain etc.

Petiolus Trachycarpi: bitter, puckery, flat, return lung, liver, large intestine channel, there is the function of hemostasis with astringents; Cure mainly epistaxis, have blood in stool, hematuria, metrorrhagia etc.

Radix Cirsii Japonici: bitter, sweet, cool, return liver, heart channel, there is the function of cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling; Cure mainly epistaxis, have blood in stool, hematuria, metrorrhagia, traumatic hemorrhage, the yellow furunculosis of skin ulcer etc.

Rhizoma Dioscoreae: sweet, flat, return spleen, stomach, lung meridian, have that spleen reinforcing nourishing the stomach, lung benefiting are promoted the production of body fluid, the function of the kidney invigorating arresting seminal emission; Cure mainly weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen, asthenia cough with asthma, spermatorrhea etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

The Radix Paeoniae Alba: bitter, acid, be slightly cold, return liver, spleen channel, there is suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for clinical symptoms and the pathological change of family's poultry infectious bursal disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition no drug residue, have no drug resistance, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Ten Herbs, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment man poultry infectious bursal disease is had to specially good effect.And make poultry product meat reach nuisanceless requirement, meet the export standard of poultry product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of Cortex Moutans, 150 parts of Rhizoma Zingiberiss, 150 parts of Radix Aconiti Lateralis Preparatas, 150 parts of the Radix Aucklandiae, 150 parts of Cortex Magnoliae Officinalis, mix 5-10 minute to even;

(3) take by weight 150 parts, Petiolus Trachycarpi, 150 parts of Radix Cirsii Japonicis, 150 parts of Rhizoma Dioscoreaes, 150 parts, Radix Glycyrrhizae, 150 parts of the Radix Paeoniae Albas, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 200 parts of Cortex Moutans, 250 parts of Rhizoma Zingiberiss, 200 parts of Radix Aconiti Lateralis Preparatas, 200 parts of the Radix Aucklandiae, 200 parts of Cortex Magnoliae Officinalis, mix 5-10 minute to even;

(3) take by weight 200 parts, Petiolus Trachycarpi, 200 parts of Radix Cirsii Japonicis, 250 parts of Rhizoma Dioscoreaes, 200 parts, Radix Glycyrrhizae, 250 parts of the Radix Paeoniae Albas, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of a poultry infectious bursal disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of Cortex Moutans, 350 parts of Rhizoma Zingiberiss, 250 parts of Radix Aconiti Lateralis Preparatas, 250 parts of the Radix Aucklandiae, 250 parts of Cortex Magnoliae Officinalis, mix 5-10 minute to even;

(3) take by weight 300 parts, Petiolus Trachycarpi, 250 parts of Radix Cirsii Japonicis, 350 parts of Rhizoma Dioscoreaes, 250 parts, Radix Glycyrrhizae, 350 parts of the Radix Paeoniae Albas, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 20-25 age in days, body weight at 0.8kg-0.9kg, the ill broiler that Laboratory Diagnosed is infectious bursal disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill poultry of feeding etc., and a day dose is: by the every 100g of the present invention, spice 250kg feeds or the 450kg that drinks water, and every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 7th day) when following table is experiment end.

Efficacy assessment standard:

Cure: spirit is normal, the drinking-water of searching for food is normal, and feces is normal, and feather is normal, breathes normally, and bouncing, cuts open inspection fabricius bursa etc. normal.

During end, there is symptom: clinical symptoms is not improved and even increased the weight of.

Table is the field applicable cases contrast of the present invention and other medicines treatment man poultry infectious bursal disease:

Numbering	Group	Mortality rate %	Cure rate %	During end, there is symptom rate %
					I	Blank group	22	41	37
II	Fuzheng Jiedu powder group	10	77	13
					III	Chinese medicine composition group of the present invention	6	88	6

This clinical effectiveness statistical analysis, present composition group is compared difference extremely significantly (P < 0.01) with Fuzheng Jiedu powder group.

Safety testing:

Choose 60 of the healthy broiler of 20 ages in days, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2 or drink water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

Above-mentioned detailed description of pure Chinese medicine composition of this treatment man poultry infectious bursal disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a pure Chinese medicine composition for a poultry infectious bursal disease, it is characterized in that by following component by weight mixed preparing form: Cortex Moutan 15-25 part, Rhizoma Zingiberis 15-35 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Aucklandiae 15-25 part, Cortex Magnoliae Officinalis 15-25 part, Petiolus Trachycarpi 15-30 part, Radix Cirsii Japonici 15-25 part, Rhizoma Dioscoreae 15-35 part, Radix Glycyrrhizae 15-25 part, Radix Paeoniae Alba 15-35 part.

2. the pure Chinese medicine composition of a treatment poultry infectious bursal disease according to claim 1, is characterized in that described various component optimum ratio amount is: 20 parts of Cortex Moutans, 25 parts of Rhizoma Zingiberiss, 20 parts of Radix Aconiti Lateralis Preparatas, 20 parts of the Radix Aucklandiae, 20 parts of Cortex Magnoliae Officinalis, 20 parts, Petiolus Trachycarpi, 20 parts of Radix Cirsii Japonicis, 25 parts of Rhizoma Dioscoreaes, 20 parts, Radix Glycyrrhizae, 25 parts of the Radix Paeoniae Albas.

3. a preparation method for the pure Chinese medicine composition for the treatment of man according to claim 1 and 2 poultry infectious bursal disease, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Cortex Moutan 15-25 part, Rhizoma Zingiberis 15-35 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Aucklandiae 15-25 part, Cortex Magnoliae Officinalis 15-25 part, mix 5-10 minute to even;

(3) take by weight Petiolus Trachycarpi 15-30 part, Radix Cirsii Japonici 15-25 part, Rhizoma Dioscoreae 15-35 part, Radix Glycyrrhizae 15-25 part, Radix Paeoniae Alba 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.