CN103599362B - Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof - Google Patents
Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for the treatment of swine enzootic pneumonia, by following component by weight mixed preparing form: Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, and clinical proof has specially good effect to treatment swine enzootic pneumonia.
Description
Technical field
The present invention relates to Chinese medicine composition and preparation method thereof for the treatment of swine enzootic pneumonia, belong to field of animal, be particularly a kind ofly specifically designed to Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof.
Background technology
Swine enzootic pneumonia is a kind of contact respiratory infectious disease caused by mycoplasma hyopneumoniae, and to cough, to pant as feature, pig farm, once infect, is difficult to thoroughly eliminate.The pig of various age and kind all can occur, and M & M is all between 5%-20%.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease is all pig-raising countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug has drug residue due to life-time service and easily produces drug resistance, and worse and worse, and drug residue causes that outlet is limited and harm people are healthy to its clinical effectiveness, thus the use of antimicrobial drug is very restricted.
Therefore researching and developing a kind of drug residue free, specific medicament of producing of having no drug resistance for the treatment of swine enzootic pneumonia is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the Chinese medicine composition and preparation method thereof of effective treatment swine enzootic pneumonia of drug residue.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of swine enzootic pneumonia, by following component by weight mixed preparing form: Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part.
Described various component optimum ratio amount is: Radix Et Rhizoma Nardostachyos 25 parts, 25 parts, Radix Glycyrrhizae, Caulis Mahoniae 25 parts, Rhizoma Polygonati Odorati 25 parts, Fructus Adinae 30 parts, Pericarpium Trichosanthis 25 parts, Matrii Sulfas Exsiccatus 30 parts, Herba Scutellariae Barbatae 30 parts, Herba Lobeliae Chinensis 30 parts, Retinervus Luffae Fructus 30 parts.
Treating a preparation method for the Chinese medicine composition of swine enzootic pneumonia, is carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part by weight, mix 5-10 minute to even;
(3) take Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Radix Et Rhizoma Nardostachyos: sweet, pungent, warm, returns spleen, stomach warp, has the function of regulating QI to relieve pain, cold expelling dampness, appetizing of being amusing; Cure mainly cold-damp disturbing the spleen, tripe distention and fullness in the abdomen, skin infection etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Caulis Mahoniae: bitter, cold, returns liver, large intestine, stomach warp, has the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly intestinal yellow dysentery, jaundice due to damp-heat, conjunctival congestion and swelling pain, laryngopharynx swelling and pain, sore etc.
Rhizoma Polygonati Odorati: sweet, cold, attaches to the lung and stomach meridians, has the function of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid; Cure mainly dryness of the lung dry cough, gastric heat, consumption of YIN caused by febrile disease, deficient fever etc.
Fructus Adinae: bitter, puckery, cool, GUIXIN, small intestinal, lung meridian, have the function of heat-clearing and toxic substances removing; Cure mainly cold, fever, laryngopharynx swelling and pain, dysentery etc.
Pericarpium Trichosanthis: sweet, cold, attaches to the lung and stomach meridians, has removing heat-phlegm, the function of eliminating stagnation of regulating the flow of vital energy; Cure mainly lung-heat cough with asthma, chest and diaphragm has a pain.
Matrii Sulfas Exsiccatus: salty, bitter, cold, returns stomach, large intestine channel, has the function of purging heat to relax the bowels, moistening for dryness and softening hard mass, clearing heat for detumescence; Cure mainly feces constipated, stagnant stomachache, excess-heat constipation, laryngopharynx swelling and pain, aphtha of the mouth and tongue, conjunctival congestion, carbuncle etc.
Herba Scutellariae Barbatae: pungent, bitter, cold, returns lung, liver, kidney channel, has the function of heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, diuresis; Cure mainly diarrhea due to damp-heat, furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice etc.
Herba Lobeliae Chinensis: pungent, flat, GUIXIN, small intestinal, lung meridian, have the function of heat-clearing and toxic substances removing, inducing diuresis to remove edema; Cure mainly edema, carbuncle furuncle etc.
Retinervus Luffae Fructus: sweet, flat, returns stomach, liver, lung meridian, the function of have dredging collateral, invigorate blood circulation, dispeling the wind; Cure mainly rheumatic arthralgia, limbs contracture, galactostasis etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for clinical symptoms and the pathological change of swine enzootic pneumonia, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment swine enzootic pneumonia, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Radix Et Rhizoma Nardostachyos 150 parts, 150 parts, Radix Glycyrrhizae, Caulis Mahoniae 150 parts, Rhizoma Polygonati Odorati 150 parts, Fructus Adinae 150 parts by weight, mix 5-10 minute to even;
(3) take Pericarpium Trichosanthis 150 parts, Matrii Sulfas Exsiccatus 150 parts, Herba Scutellariae Barbatae 150 parts, Herba Lobeliae Chinensis 150 parts, Retinervus Luffae Fructus 150 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Radix Et Rhizoma Nardostachyos 250 parts, 250 parts, Radix Glycyrrhizae, Caulis Mahoniae 250 parts, Rhizoma Polygonati Odorati 250 parts, Fructus Adinae 300 parts by weight, mix 5-10 minute to even;
(3) take Pericarpium Trichosanthis 250 parts, Matrii Sulfas Exsiccatus 300 parts, Herba Scutellariae Barbatae 300 parts, Herba Lobeliae Chinensis 300 parts, Retinervus Luffae Fructus 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of Chinese medicine composition for the treatment of swine enzootic pneumonia and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Radix Et Rhizoma Nardostachyos 350 parts, 350 parts, Radix Glycyrrhizae, Caulis Mahoniae 350 parts, Rhizoma Polygonati Odorati 350 parts, Fructus Adinae 450 parts by weight, mix 5-10 minute to even;
(3) take Pericarpium Trichosanthis 350 parts, Matrii Sulfas Exsiccatus 400 parts, Herba Scutellariae Barbatae 450 parts, Herba Lobeliae Chinensis 450 parts, Retinervus Luffae Fructus 450 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 120-130 age in days, and Laboratory Diagnosed is the ill pig of swine enzootic pneumonia.Ill pig isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, and experiment carries out 8 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Chinese medicine composition group of the present invention can by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill pig of feeding etc., day dose be: feed or the 400kg that drinks water by the present invention's every 100g spice 200kg, every day 2-3 time, be used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result at the end of experiment.
Efficacy assessment standard:
Cure: spirit is normal, drinking-water of searching for food is normal, breathes normal, the clinical symptom disappearance such as feces is normal, detects have no mycoplasma etc. in pig tracheal secretion through direct fluorescence detection.
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
Table is that the Field information situation that the present invention and other medicines treat swine enzootic pneumonia contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 33.3 | 3.3 | 63.4 |
| II | Pig asthma health is fallen apart group | 6.7 | 73.3 | 20 |
| III | Present composition group | 3.3 | 80 | 16.7 |
This clinical effectiveness statistical analysis, present composition treatment group and pig pant health fall apart group in cure rate compared with significant difference (P<0.05).
Safety testing:
Choose 90 age in days health pig 10,5 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed or are drunk water 10 days, during medication, health pig is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of Chinese medicine composition of this treatment swine enzootic pneumonia and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for swine enzootic pneumonia, it is characterized in that by following component by weight mixed preparing form:
Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part, Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part.
2. the Chinese medicine composition for the treatment of swine enzootic pneumonia according to claim 1, is characterized in that described various component optimum ratio amount is: Radix Et Rhizoma Nardostachyos 25 parts, 25 parts, Radix Glycyrrhizae, Caulis Mahoniae 25 parts, Rhizoma Polygonati Odorati 25 parts, Fructus Adinae 30 parts, Pericarpium Trichosanthis 25 parts, Matrii Sulfas Exsiccatus 30 parts, Herba Scutellariae Barbatae 30 parts, Herba Lobeliae Chinensis 30 parts, Retinervus Luffae Fructus 30 parts.
3. a preparation method for the Chinese medicine composition for the treatment of swine enzootic pneumonia according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take Radix Et Rhizoma Nardostachyos 15-35 part, Radix Glycyrrhizae 15-35 part, Caulis Mahoniae 15-35 part, Rhizoma Polygonati Odorati 15-35 part, Fructus Adinae 15-45 part by weight, mix 5-10 minute to even;
(3) take Pericarpium Trichosanthis 15-35 part, Matrii Sulfas Exsiccatus 15-40 part, Herba Scutellariae Barbatae 15-45 part, Herba Lobeliae Chinensis 15-45 part, Retinervus Luffae Fructus 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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| CN103947887B (en) * | 2014-05-09 | 2015-08-12 | 山东新希望六和集团有限公司 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating swine enzootic pneumonia |
| CN105104857A (en) * | 2015-08-28 | 2015-12-02 | 方标嵩 | Fermented feed for feeding wild porkers and production method thereof |
| CN105104858A (en) * | 2015-08-28 | 2015-12-02 | 方标嵩 | Disease-resistant traditional Chinese medicine additive for fermented feed of wild porkers |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043262A (en) * | 1989-12-08 | 1990-06-27 | 吕金博 | One boar is used the compound method of Chinese herbal medicine powder |
| CN102210813A (en) * | 2011-05-31 | 2011-10-12 | 徐斯润 | Traditional Chinese medicine composition for diminishing inflammation and relieving toxicity for livestock and poultry and preparation method thereof |
| CN102240329A (en) * | 2011-07-01 | 2011-11-16 | 佛山科学技术学院 | Chinese medicinal preparation for preventing and treating livestock lung heat syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043262A (en) * | 1989-12-08 | 1990-06-27 | 吕金博 | One boar is used the compound method of Chinese herbal medicine powder |
| CN102210813A (en) * | 2011-05-31 | 2011-10-12 | 徐斯润 | Traditional Chinese medicine composition for diminishing inflammation and relieving toxicity for livestock and poultry and preparation method thereof |
| CN102240329A (en) * | 2011-07-01 | 2011-11-16 | 佛山科学技术学院 | Chinese medicinal preparation for preventing and treating livestock lung heat syndrome |
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Effective date of registration: 20190628 Address after: 510507 No. 180 Tianyuan Road, Tianhe District, Guangzhou City, Guangdong Province, Pavilion 113A, Yangming (International) Agricultural Commodity Exchange City, Guangzhou City Patentee after: Guangzhou and Biotechnology Co., Ltd. Address before: 266000 No. 66, Nan Wang Industrial Park, Licang District, Qingdao, Shandong. Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |