CN103877472B - Chinese medicine composition for the treatment of pig streptococcicosis and preparation method thereof - Google Patents
Chinese medicine composition for the treatment of pig streptococcicosis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition treating pig streptococcicosis, following components mixed preparing by weight form: 15 35 parts of Flos Carthami, Radix Hedysari Preparata 15 45 parts, Fructus Galangae 15 55 parts, Radix Ophiopogonis 15 45 parts, Radix Polygalae 15 45 parts, Lignum Sappan 15 55 parts, the Cortex Eucommiae 15 60 parts, Fructus Evodiae 15 55 parts, Flos Ilicis Asprellae 15 65 parts, Ramulus Et Folium Picrasmae 15 70 parts, Semen Abutili 15 45 parts, 15 65 parts of Folium Pini, 15 45 parts of Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 15 45 parts.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, pollution-free, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, clinical proves that treatment pig streptococcicosis is had specially good effect.
Description
Technical field
The present invention relates to Chinese medicine composition treating pig streptococcicosis and preparation method thereof, belong to field of animal, particularly to a kind of Chinese medicine composition being specifically designed to treatment pig streptococcicosis and preparation method thereof.
Background technology
Pig streptococcicosis is a kind of deadly infectious disease being characterized with piglet arthritis, meningitis, pneumonia, septicemia and sudden death caused by Streptococcus suis.The pig of various ages and kind all can occur, and also can infect people,；M & M is all more than 50%.Primary disease the most all can occur, and is one of principal disease endangering pig industry.
This disease almost spreads over all pig-raising countries in the world, is widely distributed.At present, treating this disease and be most commonly used that Chinese medicine and antimicrobial drug, Chinese medicine is owing to its prescription is unreasonable or the simplest pulverizing, and particle diameter is excessive, and drug release is relatively slow, causes its bioavailability relatively low, and clinical effectiveness is not fine；Antimicrobial drug has drug residue and be easily generated drug resistance due to life-time service, and worse and worse, and drug residue causes exporting limited and harm people are healthy, so that the use of antimicrobial drug is very restricted for its clinical effectiveness.
Therefore research and develop a kind of drug residue free for the treatment of pig streptococcicosis, the specific medicament produced that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
It is an object of the invention to overcome above-mentioned weak point, it is provided that a kind of reasonable recipe, preparation is simple, micronizing, bioavailability high, effect substantially, have no drug resistance and the Chinese medicine composition of effectively treatment pig streptococcicosis and preparation method thereof of drug residue.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition treating pig streptococcicosis, following components mixed preparing by weight form: Flos Carthami 15-35 part, Radix Hedysari Preparata 15-45 part, Fructus Galangae 15-55 part, 15-45 part Radix Ophiopogonis, Radix Polygalae 15-45 part, Lignum Sappan 15-55 part, Cortex Eucommiae 15-60 part, Fructus Evodiae 15-55 part, Flos Ilicis Asprellae 15-65 part, Ramulus Et Folium Picrasmae 15-70 part, Semen Abutili 15-45 part, Folium Pini 15-65 part, Radix Glycyrrhizae 15-45 part, Radix Et Caulis Acanthopanacis Senticosi 15-45 part.
Described various component optimum ratio amount is: 25 parts of Flos Carthami, Radix Hedysari Preparata 30 parts, Fructus Galangae 35 parts, Radix Ophiopogonis 30 parts, Radix Polygalae 30 parts, Lignum Sappan 35 parts, the Cortex Eucommiae 40 parts, Fructus Evodiae 35 parts, Flos Ilicis Asprellae 40 parts, Ramulus Et Folium Picrasmae 40 parts, Semen Abutili 30 parts, 40 parts of Folium Pini, 30 parts of Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 30 parts.
The preparation method of a kind of Chinese medicine composition treating pig streptococcicosis, is carried out as follows:
(1) after the various compositions in prescription respectively micronizing, 700 mesh sieves are crossed；
(2) weigh Flos Carthami 15-35 part, Radix Hedysari Preparata 15-45 part, Fructus Galangae 15-55 part, 15-45 part Radix Ophiopogonis, Radix Polygalae 15-45 part, Lignum Sappan 15-55 part, Cortex Eucommiae 15-60 part by weight, mix 5-10 minute to uniformly；
(3) weigh Fructus Evodiae 15-55 part, Flos Ilicis Asprellae 15-65 part, Ramulus Et Folium Picrasmae 15-70 part, Semen Abutili 15-45 part, Folium Pini 15-65 part, Radix Glycyrrhizae 15-45 part, Radix Et Caulis Acanthopanacis Senticosi 15-45 part by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares, continue mixing 10-15 minute to uniformly.
The medicinal property of each component is as follows:
Flos Carthami: pungent, warm, returns liver, heart channel, have invigorate blood circulation, dissipating blood stasis, the function of pain relieving；Cure mainly traumatic injury, congestion pain, placenta retention, lochiorrhea etc..
Radix Hedysari Preparata: sweet, warm, returns spleen, lung meridian, has the function of invigorating the spleen and replenishing QI；Cure mainly weakness of the spleen and stomach, weak, the anorexia and loose stool of the deficiency of vital energy etc..
Fructus Galangae: pungent, warm, returns spleen, lung meridian, has dampness cold expelling, the function helped digestion of being amusing；Cure mainly Deficiency and coldness of spleen and stomach, have loose bowels, cold type of pain, dyspeptic abdominal distention etc..
Radix Ophiopogonis: sweet, bitter, cold, GUIXIN, lung, big stomach warp, there is YIN nourishing and the production of body fluid promoting, function that lung moistening clears away heart-fire；Cure mainly yin asthenia generating intrinsic heat, dryness of the lung dry cough, dryness of the intestine constipation etc..
Radix Polygalae: bitter, warm, GUIXIN, lung, kidney channel, there is the function of tranquilizing by nourishing the heart, relieving cough and reducing sputum, detumescence；Cure mainly have a guilty conscience terrified, cough with copious phlegm, epilepsy mania and irritation, spasm tic, skin sore etc..
Lignum Sappan: sweet, salty, flat, returns liver, the heart, spleen channel, has the function of promoting the circulation of blood removing blood stasis with potent drugs, reducing swelling and alleviating pain；Cure mainly traumatic injury blood stasis, blood stasis in puerperal, carbuncle etc..
The Cortex Eucommiae: sweet, warm, returns liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, antiabortive function；Cure mainly that lumbago due to renal deficiency, waist be unable, rheumatic arthralgia, frequent fetal movement etc..
Fructus Evodiae: pungent, bitter, hot, returns liver, spleen, stomach, kidney channel, has warming middle-JIAO to relieve pain, the function of preventing or arresting vomiting of regulating the flow of vital energy；Cure mainly Deficiency and coldness of spleen and stomach, cold intestinal is had loose bowels, the cold salivation of stomach etc..
Flos Ilicis Asprellae: bitter, sweet, cool, has the function of heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, dissipating blood stasis for subsidence of swelling；Cure mainly flu, heatstroke, laryngopharynx swelling and pain, thirsty, the traumatic injury of high heat etc..
Ramulus Et Folium Picrasmae: bitter, cold, returns lung, large intestine channel, has the function of heat clearing away, removing toxic substances, damp eliminating；Cure mainly anemopyretic cold, diarrhoea dysentery, eczema, skin ulcer general edema with yellowish skin poison, traumatic injury etc..
Semen Abutili: bitter, flat, returns bladder, small intestinal, large intestine channel, has the function of heat-clearing and toxic substances removing, dampness removing, nebula removing；Cure mainly dysentery, difficulty in urination, carbuncle, corneal nebula etc..
Folium Pini: bitter, puckery, warm, GUIXIN, spleen channel, have spleen invigorating regulate the flow of vital energy, the function of dispeiling pathogenic wind and removing dampness；Cure mainly swollen, the rheumatic arthralgia of food stagnation tripe etc..
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function；Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc..
Radix Et Caulis Acanthopanacis Senticosi: acrid, bitter, warm, returns spleen, kidney, heart channel, has the function of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization；Cure mainly deficiency of both the splenic and pulmonary QI, limbs fatigue, soreness of waist and knee joint, restlessness etc..
The most all taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of pig streptococcicosis, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more uniform；Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, low cost, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, preferably go out this 14 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment pig streptococcicosis there is specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, people healthy has been effectively ensured.
Detailed description of the invention
Below in conjunction with preferred embodiment, to the detailed description of the invention provided according to the present invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition treating pig streptococcicosis and preparation method thereof: carry out as follows: (every part based on 10g)
(1) after the various compositions in prescription respectively micronizing, 700 mesh sieves are crossed；
(2) weigh 150 parts of Flos Carthami, Radix Hedysari Preparata 150 parts, Fructus Galangae 150 parts, Radix Ophiopogonis 150 parts, Radix Polygalae 150 parts, Lignum Sappan 150 parts, the Cortex Eucommiae 150 parts by weight, mix 5-10 minute to uniformly；
(3) weigh Fructus Evodiae 150 parts, Flos Ilicis Asprellae 150 parts, Ramulus Et Folium Picrasmae 150 parts, Semen Abutili 150 parts, 150 parts of Folium Pini, 150 parts of Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 150 parts by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares, continue mixing 10-15 minute to uniformly.
Embodiment 2
A kind of Chinese medicine composition treating pig streptococcicosis and preparation method thereof: carry out as follows: (every part based on 10g)
(1) after the various compositions in prescription respectively micronizing, 700 mesh sieves are crossed；
(2) weigh 250 parts of Flos Carthami, Radix Hedysari Preparata 300 parts, Fructus Galangae 350 parts, Radix Ophiopogonis 300 parts, Radix Polygalae 300 parts, Lignum Sappan 350 parts, the Cortex Eucommiae 350 parts by weight, mix 5-10 minute to uniformly；
(3) weigh Fructus Evodiae 350 parts, Flos Ilicis Asprellae 400 parts, Ramulus Et Folium Picrasmae 400 parts, Semen Abutili 300 parts, 400 parts of Folium Pini, 300 parts of Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 300 parts by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares, continue mixing 10-15 minute to uniformly.
Embodiment 3
A kind of Chinese medicine composition treating pig streptococcicosis and preparation method thereof: carry out as follows: (every part based on 10g)
(1) after the various compositions in prescription respectively micronizing, 700 mesh sieves are crossed；
(2) weigh 350 parts of Flos Carthami, Radix Hedysari Preparata 450 parts, Fructus Galangae 550 parts, Radix Ophiopogonis 450 parts, Radix Polygalae 450 parts, Lignum Sappan 550 parts, the Cortex Eucommiae 600 parts by weight, mix 5-10 minute to uniformly；
(3) weigh Fructus Evodiae 550 parts, Flos Ilicis Asprellae 650 parts, Ramulus Et Folium Picrasmae 700 parts, Semen Abutili 450 parts, 650 parts of Folium Pini, 450 parts of Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 450 parts by weight, mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), compositions that (3) step prepares, continue mixing 10-15 minute to uniformly.
Clinical trial:
Clinical experiment animal selects 80-90 age in days, body weight at 35kg-45kg, and Laboratory Diagnosed is the ill pig of pig streptococcicosis.The isolation of ill pig individually being raised, feed complete feed, and be randomly divided into 3 groups, often group 30,3 groups of feeding environments are identical, and experiment is carried out 7 days altogether；Blank group is left intact, and drug control group institute's control drug is used according to an instruction treatment；Chinese medicine composition group of the present invention can by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill pig of feeding etc., day dose be: feed by the present invention every 100g spice 210kg, every day 2-3 time, be used in conjunction 3-5 day；Reach to treat the purpose of disease by gastrointestinal absorption after Kou Fu.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result at the end of experiment.
Pig streptococcicosis efficacy assessment standard:
Curing: spirit is normal, drinking-water of searching for food is normal, and body temperature is normal, and feces is normal, bouncing, and laboratory PCR diagnosis has no the distinctive virulence gene of Streptococcus suis (cps2A, mrp, gapdh, sly, ef).
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
Table is the Field information situation contrast of the present invention and other medicines treatment pig streptococcicosis:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 26.7 | 0 | 73.3 |
| II | Pig chain bacterium dissipates group | 10 | 66.7 | 23.3 |
| III | Present composition group | 6.7 | 76.7 | 16.6 |
This clinical effectiveness statistical analysis, it is extremely notable (P < 0.01) that present composition treatment group dissipates group difference compared with in terms of cure rate with pig chain bacterium.
Safety testing:
Choose 70 age in days health pig 10,10 days are fed according to 5 times of spices of the embodiment of the present invention 2 made compositions recommended dose, during medication, health pig does not has any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is the most notable that body weight increase compares difference with blank group (i.e. health is not administered group).
Above-mentioned detailed description Chinese medicine composition of this treatment pig streptococcicosis and preparation method thereof carried out with reference to embodiment; it is illustrative rather than determinate; can according to restriction scope list several embodiments; therefore changing and modifications under without departing from present general inventive concept, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for pig streptococcicosis, it is characterized in that by following components by weight
Amount number mixed preparing forms:
Flos Carthami 15-35 part, Radix Hedysari Preparata 15-45 part, Fructus Galangae 15-55 part, 15-45 part Radix Ophiopogonis,
Radix Polygalae 15-45 part, Lignum Sappan 15-55 part, Cortex Eucommiae 15-60 part, Fructus Evodiae 15-55 part, hilllock
Prunus mume (sieb.) sieb.et zucc. 15-65 part, Ramulus Et Folium Picrasmae 15-70 part, Semen Abutili 15-45 part, Folium Pini 15-65 part, Radix Glycyrrhizae
15-45 part, Radix Et Caulis Acanthopanacis Senticosi 15-45 part.
The Chinese medicine composition for the treatment of pig streptococcicosis the most according to claim 1, its feature
It is to be formed by following components mixed preparing by weight:
25 parts of Flos Carthami, Radix Hedysari Preparata 30 parts, Fructus Galangae 35 parts, Radix Ophiopogonis 30 parts, Radix Polygalae 30
Part, Lignum Sappan 35 parts, the Cortex Eucommiae 40 parts, Fructus Evodiae 35 parts, Flos Ilicis Asprellae 40 parts, Ramulus Et Folium Picrasmae 40 parts,
Semen Abutili 30 parts, 40 parts of Folium Pini, 30 parts of Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi 30 parts.
3. the system of the Chinese medicine composition of a treatment pig streptococcicosis according to claim 1
Preparation Method, is characterized in that carrying out as follows:
(1) after the various compositions in prescription respectively micronizing, 700 mesh sieves are crossed；
(2) weigh by weight Flos Carthami 15-35 part, Radix Hedysari Preparata 15-45 part, Fructus Galangae 15-55 part,
Radix Ophiopogonis 15-45 part, Radix Polygalae 15-45 part, Lignum Sappan 15-55 part, Cortex Eucommiae 15-60 part, mixing
5-10 minute to uniformly；
(3) weigh by weight Fructus Evodiae 15-55 part, Flos Ilicis Asprellae 15-65 part, Ramulus Et Folium Picrasmae 15-70 part,
Semen Abutili 15-45 part, Folium Pini 15-65 part, Radix Glycyrrhizae 15-45 part, Radix Et Caulis Acanthopanacis Senticosi 15-45 part,
Mix 5-10 minute to uniformly；
(4) merge above-mentioned (2), (3) step prepare compositions, continue mixing 10-15 minute extremely
Uniformly.
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| CN102327439A (en) * | 2011-09-19 | 2012-01-25 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese herbal medicine for treating septicemia |
| WO2013071723A1 (en) * | 2011-11-16 | 2013-05-23 | 南京森楠生物技术研究有限公司 | Preparation method of antibacterial lipopeptide and application thereof to veterinary medicine |
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| CN102327439A (en) * | 2011-09-19 | 2012-01-25 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese herbal medicine for treating septicemia |
| WO2013071723A1 (en) * | 2011-11-16 | 2013-05-23 | 南京森楠生物技术研究有限公司 | Preparation method of antibacterial lipopeptide and application thereof to veterinary medicine |
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| 对人感染猪链球菌病的中医认识;周晓虹等;《中国中医急症》;20060131;第15卷(第01期);62-63 * |
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