CN102784219B - Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same - Google Patents
Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same Download PDFInfo
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Abstract
The invention relates to a compound pure Chinese medicine composition for treating bovine ephemeral fever and a preparation method of the compound pure Chinese medicine composition. The composition is prepared by mixing the following components in part by weight: 25-45 parts of plaster, 25-35 parts of platycodon root, 25-35 parts of cape jasmine fruit, 15-35 parts of menthol, 15-35 parts of mulberry leaf, 15-35 parts of pepper stem, 25-45 parts of licorice, 25-45 parts of dried orange peel, 15-45 parts of ephedra, and 15-45 parts of baical skullcap root. The compound pure Chinese medicine composition has the benefits of reasonable formula, simplicity in preparation, no toxic or side effect, no pollution, no medicinal residue, no drug tolerance, ultrafine particles, high bioavailability and very remarkable curative effect, and has a specially good effect on treating bovine ephemeral fever, which is proved clinically.
Description
Technical field
The compound pure Chinese medicine composition and method of making the same that the present invention relates to treat Niu Liuhang heat, belongs to animal field of medicaments, particularly a kind of compound pure Chinese medicine composition and method of making the same that is specifically designed to treatment Niu Liuhang heat.
Background technology
The popular heat of cattle (having another name called Ephemeral fever) is a kind of acute heat sexually transmitted disease being caused by bovine epizootic fever virus.It is characterized by unexpected high heat, tachypnea, sheds tears and Alimentary serious catarrhal inflammation and the dyskinesia.The sick cattle of part that infects this disease recovered normal through 2～3, therefore claim again Ephemeral fever or temporarily hot.This disease is mainly encroached on cattle, milk cattle, Babalus bubalis L. etc., with 3 years old～5 years old prime of life cattle, milk cattle, cattle susceptibility maximum.This disease is popular swift and violent, can make in a short time large quantities of cattle only fall ill, and is endemicity or large fluidity.Acute death is many because of due to suffocating.Cut open inspection visible trachea and bronchus mucosa hyperemia and petechial hemorrhage, mucosa swelling, is full of a large amount of foam mucus in trachea.The remarkable enlargement of lung, has edema and interstitial edema due to disorder of QI that degree is different, pressure have a crepitation.Lymph nodes of body as a whole hyperemia, swelling or hemorrhage.Straight stomach, small intestinal and caecum mucosa are catarrhal inflammation and hemorrhage.Other substantial viscera visible haze swelling.This condition of disease causes Niu great Qun morbidity, and sickness rate is up to more than 20%, and mortality rate, between 1%～5%, can obviously reduce the milk production of milk cattle, to producing to cause, has a strong impact on.
This disease almost spreads all over the world all cowboying country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug and antipyretic analgesic medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug and antipyretic analgesic are because life-time service has drug residue and easily produces drug resistance, its clinical effectiveness worse and worse, and drug residue causes exporting limited and harm people are healthy, thereby the use of antimicrobial drug and antipyretic analgesic is very restricted.
Therefore research and develop a kind of Niu Liuhang for the treatment of heat drug residue free, have no drug resistance produce specific medicament be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound pure Chinese medicine composition and method of making the same of effective treatment Niu Liuhang heat of drug residue.
Implementation of the present invention is as follows for achieving the above object: a kind of compound pure Chinese medicine compositions for the treatment of Niu Liuhang heat, by following component by weight mixed preparing form: Gypsum Fibrosum 25-45 part, Radix Platycodonis 25-35 part, Fructus Gardeniae 25-35 part, Herba Menthae 15-35 part, Folium Mori 15-35 part, Caulis Piperis Kadsurae 15-35 part, Radix Glycyrrhizae 25-45 part, Pericarpium Citri Reticulatae 25-45 part, Herba Ephedrae 15-45 part, Radix Scutellariae 15-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 35 parts, Gypsum Fibrosum, 30 parts of Radix Platycodoniss, 30 parts of Fructus Gardeniaes, 25 parts of Herba Menthaes, 25 parts, Folium Mori, 25 parts of Caulis Piperis Kadsuraes, 35 parts, Radix Glycyrrhizae, 35 parts of Pericarpium Citri Reticulataes, 30 parts, Herba Ephedrae, 30 parts of Radix Scutellariaes.
Treat a preparation method for the compound pure Chinese medicine compositions of Niu Liuhang heat, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Gypsum Fibrosum 25-45 part, Radix Platycodonis 25-35 part, Fructus Gardeniae 25-35 part, Herba Menthae 15-35 part, Folium Mori 15-35 part, mix 5-10 minute to even;
(3) take by weight Caulis Piperis Kadsurae 15-35 part, Radix Glycyrrhizae 25-45 part, Pericarpium Citri Reticulatae 25-45 part, Herba Ephedrae 15-45 part, Radix Scutellariae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Gypsum Fibrosum: sweet, pungent, cold, attach to the lung and stomach meridians, there is the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Radix Platycodonis: bitter, pungent, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Herba Menthae: pungent, cool, return lung, Liver Channel, there is the function of wind-dispelling heat-dissipating, the cleaning head, sore-throat relieving, rash; Cure mainly affection due to external wind and heat, laryngopharynx swelling and pain, conjunctival congestion, rubella etc.
Folium Mori: sweet, bitter, cold, return lung, Liver Channel, there is the function of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving; Curing mainly anemopyretic cold, cough due to lung-heat, conjunctival congestion sheds tears etc.
Caulis Piperis Kadsurae: sweet, warm, return liver, kidney channel, there is the function of warming the kidney to invigorate YANG, mass dissipating and swelling eliminating; Cure mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, edema etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Herba Ephedrae: micro-hardship, temperature, pungent, return lung, urinary bladder channel, there is the function of the cold expelling that induces sweat, depressed lung-energy dispersing, inducing diuresis to remove edema; Cure mainly affection of exogenous wind-cold, cough, asthma, edema etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for clinical symptoms and the pathological change of Niu Liuhang heat, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment Niu Liuhang heat is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound pure Chinese medicine composition and method of making the same of the Niu Liuhang for the treatment of heat: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts, Gypsum Fibrosum, 250 parts of Radix Platycodoniss, 250 parts of Fructus Gardeniaes, 150 parts of Herba Menthaes, 150 parts, Folium Mori, mix 5-10 minute to even;
(3) take by weight 150 parts of Caulis Piperis Kadsuraes, 250 parts, Radix Glycyrrhizae, 250 parts of Pericarpium Citri Reticulataes, 150 parts, Herba Ephedrae, 150 parts of Radix Scutellariaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound pure Chinese medicine composition and method of making the same of the Niu Liuhang for the treatment of heat: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts, Gypsum Fibrosum, 300 parts of Radix Platycodoniss, 300 parts of Fructus Gardeniaes, 250 parts of Herba Menthaes, 250 parts, Folium Mori, mix 5-10 minute to even;
(3) take by weight 250 parts of Caulis Piperis Kadsuraes, 350 parts, Radix Glycyrrhizae, 350 parts of Pericarpium Citri Reticulataes, 300 parts, Herba Ephedrae, 300 parts of Radix Scutellariaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound pure Chinese medicine composition and method of making the same of the Niu Liuhang for the treatment of heat: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 450 parts, Gypsum Fibrosum, 350 parts of Radix Platycodoniss, 350 parts of Fructus Gardeniaes, 350 parts of Herba Menthaes, 350 parts, Folium Mori, mix 5-10 minute to even;
(3) take by weight 350 parts of Caulis Piperis Kadsuraes, 450 parts, Radix Glycyrrhizae, 450 parts of Pericarpium Citri Reticulataes, 450 parts, Herba Ephedrae, 450 parts of Radix Scutellariaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal is selected the 25-26 monthly age, and Laboratory Diagnosed is the milch cow of Niu Liuhang heat, and isolated separately and raised, the complete feed of feeding, and be divided at random 3 groups, and 10 every group, 3 groups of feeding environments are identical, and test period is 5 days; Blank group is left intact, and medicine matched group is used treatment with " cattle GANKANG is loose " by specification; Chinese medicine composition group of the present invention can be by product of the present invention (the prepared compositions of the embodiment of the present invention 1) the ill cattle of feeding etc., and a day dose is: boiled water soaks, and waits temperature to gavage, and by the each 200g of product of the present invention, every day 1 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 5th day) when following table is experiment end.
Table is the contrast of the situation of the present invention and other medicines treatment Niu Liuhang heat:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 30.0 | 40.0 | 30.0 |
| II | The cattle GANKANG group of faling apart | 10.0 | 80.0 | 10.0 |
| III | Present composition group | 0 | 90.0 | 10.0 |
This clinical effectiveness statistical analysis, the loose group of present composition treatment group and cattle GANKANG extremely significantly (P < 0.01) of difference compared with aspect cure rate.
Safety testing:
Choose 10 of 150 age in days healthy cows, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 gavage 5 days, during medication, healthy cow is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of the compound pure Chinese medicine composition and method of making the same of this treatment Niu Liuhang heat being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound pure Chinese medicine compositions for Niu Liuhang heat, it is characterized in that by following component by weight mixed preparing form: Gypsum Fibrosum 25-45 part, Radix Platycodonis 25-35 part, Fructus Gardeniae 25-35 part, Herba Menthae 15-35 part, Folium Mori 15-35 part, Caulis Piperis Kadsurae 15-35 part, Radix Glycyrrhizae 25-45 part, Pericarpium Citri Reticulatae 25-45 part, Herba Ephedrae 15-45 part, Radix Scutellariae 15-45 part.
2. the compound pure Chinese medicine compositions for the treatment of according to claim 1 Niu Liuhang heat, it is characterized in that by following component by weight mixed preparing form: 35 parts, Gypsum Fibrosum, 30 parts of Radix Platycodoniss, 30 parts of Fructus Gardeniaes, 25 parts of Herba Menthaes, 25 parts, Folium Mori, 25 parts of Caulis Piperis Kadsuraes, 35 parts, Radix Glycyrrhizae, 35 parts of Pericarpium Citri Reticulataes, 30 parts, Herba Ephedrae, 30 parts of Radix Scutellariaes.
3. a preparation method for the compound pure Chinese medicine compositions for the treatment of Niu Liuhang heat according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Gypsum Fibrosum 25-45 part, Radix Platycodonis 25-35 part, Fructus Gardeniae 25-35 part, Herba Menthae 15-35 part, Folium Mori 15-35 part, mix 5-10 minute to even;
(3) take by weight Caulis Piperis Kadsurae 15-35 part, Radix Glycyrrhizae 25-45 part, Pericarpium Citri Reticulatae 25-45 part, Herba Ephedrae 15-45 part, Radix Scutellariae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210269799.5A CN102784219B (en) | 2012-08-01 | 2012-08-01 | Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same |
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| CN201210269799.5A CN102784219B (en) | 2012-08-01 | 2012-08-01 | Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same |
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| CN102784219A CN102784219A (en) | 2012-11-21 |
| CN102784219B true CN102784219B (en) | 2014-04-30 |
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| CN104208090B (en) * | 2014-09-18 | 2016-08-17 | 山东农业大学 | A kind of preventing and treating Bovine Ephemeral Fever compositions |
| CN104256094A (en) * | 2014-09-28 | 2015-01-07 | 山东新希望六和集团有限公司 | Functional feed for preventing and treating bovine ephemeral fever and preparation method of functional feed |
| CN104258211A (en) * | 2014-09-28 | 2015-01-07 | 山东新希望六和集团有限公司 | Traditional Chinese medicine composition for preventing and treating bovine ephemeral fever and preparation method of traditional Chinese medicine composition |
| CN104288686A (en) * | 2014-10-13 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine and western medicine composition for treating bovine damp-heat type epherl fever and preparation method of composition |
| CN104970234A (en) * | 2015-06-29 | 2015-10-14 | 何以安 | Feed additive for preventing and treating bovine epizootic fever of cows |
| CN106668817A (en) * | 2017-01-24 | 2017-05-17 | 广西山水牛农业有限责任公司 | Medicine capable of treating bovine epizootic fever |
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