CN102961515A - Compound propolis combination for treating swine erysipelas and preparation method of combination - Google Patents
Compound propolis combination for treating swine erysipelas and preparation method of combination Download PDFInfo
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Abstract
The invention relates to the field of animal medicines, and particularly relates to a compound propolis combination for treating swine erysipelas. The compound propolis combination is prepared by mixing the following components in parts by weight: 15 to 35 parts of propolis, 15 to 35 parts of rheum officinale, 15 to 35 parts of burdock, 15 to 35 parts of herba taching, 15 to 45 parts of gentiana scabra bge, 15 to 35 parts of cortex moutan, 15 to 40 parts of liquorice, 15 to 45 parts of cape jasmine fruit, 15 to 45 parts of pericarpium citri reticulatae, and 15 to 45 parts of fructus forsythia. The compound propolis combination has the beneficial effects of being reasonable in composition and simple to prepare, being free from toxic and side effects, pollution, drug residues and tolerance, achieving high biological availability as being subjected to superfine grinding, having a greatly remarkable curative effect, and having a special effect on treating the swine erysipelas according to clinical evidence.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof, belong to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment swine erysipelas and preparation method thereof.
Background technology
Swine erysipelas is acute, the hot infectious disease that is caused by bacillus rhusiopathiae suis.Be characterized as acute sepsis, subacute skin rash piece, chronic is polyarthritis and endocarditis.The pig of various ages and kind all can occur, and M ﹠ M is all between 5%-20%.Primary disease all can occur throughout the year, is one of principal disease of serious harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug since life-time service drug residue is arranged and easily produces drug resistance, its clinical effectiveness worse and worse, and drug residue causes exporting limited and the harm people are healthy, thereby the use of antimicrobial drug is very restricted.
Therefore research and develop and a kind ofly treat the drug residue free of swine erysipelas, the specific medicament that produces that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability height, successful, have no drug resistance and the compound bee-glue composition of effective treatment swine erysipelas of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of swine erysipelas, by following component by weight mixed preparing form: propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part.
On the basis of such scheme, by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Fructus Arctiis, 25 parts of Folium Isatidiss, 30 parts of Radix Gentianaes, 25 parts of Cortex Moutans, 25 parts in Radix Glycyrrhizae, 30 parts of Fructus Gardeniaes, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Forsythiaes.
A kind of preparation method for the treatment of the compound bee-glue composition of swine erysipelas, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Fructus Arctii: hot, bitter, cold, attach to the lung and stomach meridians, have the function of dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat; Cure mainly affection due to external wind and heat, cough and asthma, laryngopharynx swelling and pain, carbuncle sore tumefacting virus etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Radix Gentianae: bitter, cold, return liver, gallbladder meridian, have eliminating pathogen in the liver gallbladder excess-fire, except the function of damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.
Cortex Moutan: bitter, hot, cold, return liver, the heart, kidney channel, have the function of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Cure mainly maculae caused by violent heat pathogen, epistaxis, have blood in stool, hematuria, traumatic injury, carbuncle sore tumefacting virus etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Pericarpium Citri Reticulatae: bitter, hot, warm, return lung, spleen channel, have the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly that poor appetite, stomachache, tripe expand, have loose bowels, productive cough due to phlegm-damp etc.
Fructus Forsythiae: bitter, cold, return lung, the heart, small intestine meridian, have the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of swine erysipelas, the performance treating both the principal and secondary aspects of a disease effect.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, the treatment swine erysipelas there is specially good effect, and make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of propolis, 150 parts of Radix Et Rhizoma Rhei, 150 parts of Fructus Arctiis, 150 parts of Folium Isatidiss, 150 parts of Radix Gentianaes, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Cortex Moutans, 150 parts in Radix Glycyrrhizae, 150 parts of Fructus Gardeniaes, 150 parts of Pericarpium Citri Reticulataes, 150 parts of Fructus Forsythiaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of propolis, 250 parts of Radix Et Rhizoma Rhei, 250 parts of Fructus Arctiis, 250 parts of Folium Isatidiss, 300 parts of Radix Gentianaes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Cortex Moutans, 250 parts in Radix Glycyrrhizae, 300 parts of Fructus Gardeniaes, 300 parts of Pericarpium Citri Reticulataes, 300 parts of Fructus Forsythiaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of propolis, 350 parts of Radix Et Rhizoma Rhei, 350 parts of Fructus Arctiis, 350 parts of Folium Isatidiss, 450 parts of Radix Gentianaes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Cortex Moutans, 400 parts in Radix Glycyrrhizae, 450 parts of Fructus Gardeniaes, 450 parts of Pericarpium Citri Reticulataes, 450 parts of Fructus Forsythiaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 75-85 age in days, body weight at 35kg-45kg, and Laboratory Diagnosed is the ill pig of swine erysipelas.Ill pig isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " the pig erysipelas health is loose " by specification; Chinese medicine composition group of the present invention can be with product of the present invention (embodiment of the invention 1 prepared compositions) the ill pig of feeding etc., and a day dose is: by the every 100g of the present invention, spice 280kg feeds, and every day 2-3 time, is used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the situation contrast of the present invention and other medicines treatment swine erysipelas:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 13.3 | 60.9 | 26.7 |
| II | The loose group of pig erysipelas health | 6.7 | 80.0 | 13.3 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of pig erysipelas health aspect the cure rate.
Safety testing:
Choose 10 of 70 age in days health pig, 5 times of spices according to the embodiment of the invention 1 made compositions recommended dose were fed 10 days, during the medication, health pig is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of compound bee-glue composition of this treatment swine erysipelas and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition for the treatment of swine erysipelas, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part.
2. the compound bee-glue composition for the treatment of swine erysipelas according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Radix Et Rhizoma Rhei, 25 parts of Fructus Arctiis, 25 parts of Folium Isatidiss, 30 parts of Radix Gentianaes, 25 parts of Cortex Moutans, 25 parts in Radix Glycyrrhizae, 30 parts of Fructus Gardeniaes, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Forsythiaes.
3. the preparation method of the compound bee-glue composition of a treatment swine erysipelas according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight propolis 15-35 part, Radix Et Rhizoma Rhei 15-35 part, Fructus Arctii 15-35 part, Folium Isatidis 15-35 part, Radix Gentianae 15-45 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Moutan 15-35 part, Radix Glycyrrhizae 15-40 part, Fructus Gardeniae 15-45 part, Pericarpium Citri Reticulatae 15-45 part, Fructus Forsythiae 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105362430A (en) * | 2015-11-15 | 2016-03-02 | 衡阳市金凤牲猪养殖专业合作社 | Drug for preventing and curing swine erysipelas, and preparation method thereof |
| CN107281427A (en) * | 2017-06-28 | 2017-10-24 | 石阡县金桥农牧发展有限责任公司 | A kind of feed addictive for preventing and treating brickpox |
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| CN102727669A (en) * | 2012-06-20 | 2012-10-17 | 青岛绿曼生物工程有限公司 | Compound propolis composition used for treating swine erysipelas, and preparation method thereof |
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| CN102961515B (en) | 2016-04-27 |
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