CN102961516B - Pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof - Google Patents
Pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof Download PDFInfo
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- CN102961516B CN102961516B CN201210516203.7A CN201210516203A CN102961516B CN 102961516 B CN102961516 B CN 102961516B CN 201210516203 A CN201210516203 A CN 201210516203A CN 102961516 B CN102961516 B CN 102961516B
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Abstract
The present invention relates to a kind of pure Chinese medicine composition for the treatment of duck viral hepatitis, by following component by weight mixed preparing form: propolis 15-35 part, Folium Isatidis 15-40 part, Radix Puerariae 15-35 part, Alumen 20-55 part, Herba Equiseti Hiemalis 10-30 part, Cinnabaris 10-20 part, Massa Medicata Fermentata 20-45 part, Semen phaseoli radiati 15-40 part, Radix Gentianae 15-35 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and pure Chinese medicine composition has no side effect, pollution-free, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, clinical proof has specially good effect to treatment duck viral hepatitis.
Description
Technical field
The present invention relates to pure Chinese medicine composition and preparation method thereof for the treatment of duck viral hepatitis, belong to field of animal, be particularly a kind ofly specifically designed to pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof.
Background technology
Duck viral hepatitis is a kind of common acute, the height lethal infectious diseases that are caused by DHV, duckling within 2 week age of main infection, clinically with opisthotonus, beak end and pawl point congestion and in mulberry for feature, cut open the visible liver enlargement of inspection and have a large amount of haemorrhagic puncta, mortality rate is very high, is that one of principal disease of duck industry is supported in harm.
The pathogen of primary disease is DHV, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And various antiviral Western medicine is as ribavirin, amantadine etc., the Ministry of Agriculture prohibits the use.
Therefore researching and developing a kind of specific medicament for the treatment of duck viral hepatitis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the pure Chinese medicine composition and preparation method thereof of effective treatment duck viral hepatitis of toxic and side effects.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of duck viral hepatitis, by following component by weight mixed preparing form: propolis 15-35 part, Folium Isatidis 15-40 part, Radix Puerariae 15-35 part, Alumen 20-55 part, Herba Equiseti Hiemalis 10-30 part, Cinnabaris 10-20 part, Massa Medicata Fermentata 20-45 part, Semen phaseoli radiati 15-40 part, Radix Gentianae 15-35 part.
Described various component optimum ratio amount is: propolis 25 parts, Folium Isatidis 30 parts, Radix Puerariae 25 parts, 35 parts, Alumen, Herba Equiseti Hiemalis 20 parts, 15 parts, Cinnabaris, Massa Medicata Fermentata 35 parts, 25 parts, Semen phaseoli radiati, Radix Gentianae 25 parts.
Treat a preparation method for the pure Chinese medicine composition of duck viral hepatitis, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Folium Isatidis 15-40 part, Radix Puerariae 15-35 part, Alumen 20-55 part by weight, mix 5-10 minute to even;
(3) take Herba Equiseti Hiemalis 10-30 part, Cinnabaris 10-20 part, Massa Medicata Fermentata 20-45 part, Semen phaseoli radiati 15-40 part, Radix Gentianae 15-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, stomach warp, has anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improves immunity, antiallergic is oxidized, the function of the gastrointestinal mucosa that stops blooding, protects.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Radix Puerariae: sweet, pungent, cool, returns stomach, spleen channel, has the function of expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal; Cure mainly that fever caused by exogenous pathogens, gastric heat are thirsty, varioliform exanthema, diarrhea due to hypofunction of the spleen etc.
Alumen: cold, sour, puckery, returns lung, spleen, large intestine, Liver Channel, has the function of heat clearing away expectorant, hemostasis antidiarrheal, dampness removing to stop itchin, removing toxic substances parasite killing; Cure mainly incessant chronic diarrhea, have blood in stool, let out dysentery after heavily etc.
Herba Equiseti Hiemalis: sweet, bitter, flat, returns lung, Liver Channel, has loose wind heat, moves back the function of corneal nebula; Cure mainly conjunctival congestion and swelling pain, epiphora induced by wind, pterygium etc.
Cinnabaris: sweet, be slightly cold, GUIXIN warp, has the function that is relieving convulsion, that calm the nerves, detoxify that clears away heart-fire; Cure mainly heat in the heart ailment said due to cold or exposure, restlessness, calentura epilepsy, sore swollen toxin etc.
Massa Medicata Fermentata: sweet, pungent, warm, returns stomach, spleen channel, has invigorating the spleen and regulating the stomach, help digestion the function in adjusting; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.
Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, have heat-clearing and toxic substances removing, a function of stomach invigorating of relieving summer heat; Cure mainly diarrhea due to damp-heat, removing toxic substances protects the liver, antiallergic.
Radix Gentianae:: bitter, cold, return liver, gallbladder meridian, there is eliminating pathogen in the liver gallbladder excess-fire, function except damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the pathogenic microorganism of duck viral hepatitis, clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this nine tastes Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment duck viral hepatitis, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 150 parts, Folium Isatidis 150 parts, Radix Puerariae 150 parts, 200 parts, Alumen by weight, mix 5-10 minute to even;
(3) take Herba Equiseti Hiemalis 100 parts, 100 parts, Cinnabaris, Massa Medicata Fermentata 200 parts, 150 parts, Semen phaseoli radiati, Radix Gentianae 150 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 250 parts, Folium Isatidis 250 parts, Radix Puerariae 250 parts, 400 parts, Alumen by weight, mix 5-10 minute to even;
(3) take Herba Equiseti Hiemalis 200 parts, 150 parts, Cinnabaris, Massa Medicata Fermentata 300 parts, 250 parts, Semen phaseoli radiati, Radix Gentianae 250 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 350 parts, Folium Isatidis 400 parts, Radix Puerariae 350 parts, 550 parts, Alumen by weight, mix 5-10 minute to even;
(3) take Herba Equiseti Hiemalis 300 parts, 200 parts, Cinnabaris, Massa Medicata Fermentata 450 parts, 400 parts, Semen phaseoli radiati, Radix Gentianae 350 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20-30 age in days, body weight at 1.2kg-1.5kg, and Laboratory Diagnosed is the ill meat duck of duck viral hepatitis.Ill duck isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 60,3 groups of feeding environments are identical, and experimental period carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Present composition group can by product of the present invention (compositions obtained by the embodiment of the present invention 1) the ill duck of feeding etc., day dose be: by the every 100g of the present invention, spice 240kg feeds, and drinking-water 400kg, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the situation that the present invention and other medicines treat duck viral hepatitis contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 31.7 | 48.3 | 20.0 |
| II | Duck poison health is fallen apart group | 11.7 | 74.2 | 15.0 |
| III | Hepatitis recovery oral liquid group | 10.0 | 78.3 | 11.7 |
| IV | Chinese medicine composition group of the present invention | 6.7 | 85.0 | 8.3 |
This clinical effectiveness statistical analysis, present composition treatment group and duck poison health fall apart group, hepatitis recovery oral liquid group in cure rate compared with difference extremely significantly (P < 0.01) and remarkable (P < 0.05).
Safety testing:
Choose the healthy meat-type duck 60 of 20 ages in days, 10 times of spices according to the made compositions recommended dose of the embodiment of the present invention 1 are fed 10 days, during medication, healthy duck is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of pure Chinese medicine composition of this treatment duck viral hepatitis and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for duck viral hepatitis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Folium Isatidis 15-40 part, Radix Puerariae 15-35 part, Alumen 20-55 part, Herba Equiseti Hiemalis 10-30 part, Cinnabaris 10-20 part, Massa Medicata Fermentata 20-45 part, Semen phaseoli radiati 15-40 part, Radix Gentianae 15-35 part.
2. the pure Chinese medicine composition for the treatment of duck viral hepatitis according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, Folium Isatidis 30 parts, Radix Puerariae 25 parts, 35 parts, Alumen, Herba Equiseti Hiemalis 20 parts, 15 parts, Cinnabaris, Massa Medicata Fermentata 35 parts, 25 parts, Semen phaseoli radiati, Radix Gentianae 25 parts.
3. a preparation method for the pure Chinese medicine composition for the treatment of duck viral hepatitis according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Folium Isatidis 15-40 part, Radix Puerariae 15-35 part, Alumen 20-55 part by weight, mix 5-10 minute to even;
(3) take Herba Equiseti Hiemalis 10-30 part, Cinnabaris 10-20 part, Massa Medicata Fermentata 20-45 part, Semen phaseoli radiati 15-40 part, Radix Gentianae 15-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210516203.7A CN102961516B (en) | 2012-11-22 | 2012-11-22 | Pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210516203.7A CN102961516B (en) | 2012-11-22 | 2012-11-22 | Pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof |
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| CN102961516A CN102961516A (en) | 2013-03-13 |
| CN102961516B true CN102961516B (en) | 2015-11-25 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683490A (en) * | 2009-05-18 | 2010-03-31 | 中山市新运来医药科技开发有限公司 | Chinese medicinal granule preparation for preventing and treating influenza A(H1N1) virus occurring in humans and pigs |
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- 2012-11-22 CN CN201210516203.7A patent/CN102961516B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683490A (en) * | 2009-05-18 | 2010-03-31 | 中山市新运来医药科技开发有限公司 | Chinese medicinal granule preparation for preventing and treating influenza A(H1N1) virus occurring in humans and pigs |
Non-Patent Citations (2)
| Title |
|---|
| 《中草药治疗鸭病毒性肝炎概述》;陈昌霞;《畜禽业》;20031231(第3期);64页右栏 * |
| 《探析鸭病毒性肝炎的中草药治疗》;何永明;《广东畜牧兽医科技》;19960331;第21卷(第3期);41-42 * |
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