CN104922573A - Pure traditional Chinese medicine composition for treating duck virus hepatitis and preparation method thereof - Google Patents

Abstract

The invention relates to a pure traditional Chinese medicine composition for treating duck virus hepatitis. The pure traditional Chinese medicine composition is prepared by mixing the following components in parts by weight: 15-45 parts of pimpinella thellungiana, 10-50 parts of borneol, 15-45 parts of berba aristolochiae mollissimae, 15-35 parts of radix stephaniae tetrandrae, 20-50 parts of radix saposhnikoviae, 15-45 parts of liquorice, 20-45 parts of safflower, 20-40 parts of malt, 15-55 parts of manyinflorescenced sweetvetch root, 15-45 parts of fructus galangae, 15-45 parts of polygala tenuifolia and 15-45 parts of halloysitum rubrum. The pure traditional Chinese medicine composition has the beneficial effects that the pure traditional Chinese medicine composition is reasonable in formula, simple to prepare, free of toxic and side effects, free of medicine residues, free of medicine resistance, high in bioavailability and very obvious in curative effect, the pure traditional Chinese medicine composition can be super finely ground, and clinically-proven results show that the pure traditional Chinese medicine composition has the special treatment effect on duck virus hepatitis.

Description

Pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof

Technical field

The present invention relates to pure Chinese medicine composition and preparation method thereof for the treatment of duck viral hepatitis, belong to field of animal, be particularly a kind ofly specifically designed to pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof.

Background technology

Duck viral hepatitis is a kind of common acute, the height lethal infectious diseases that are caused by DHV, duckling within 2 week age of main infection, clinically with opisthotonus, beak end and pawl point congestion and in mulberry for feature, cut open the visible liver enlargement of inspection and have a large amount of haemorrhagic puncta, mortality rate is very high, is that one of principal disease of duck industry is supported in harm.

The pathogen of primary disease is DHV, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And various antiviral Western medicine is as ribavirin, amantadine etc., the Ministry of Agriculture prohibits the use.

Therefore researching and developing a kind of specific medicament for the treatment of duck viral hepatitis is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the pure Chinese medicine composition and preparation method thereof of effective treatment duck viral hepatitis of toxic and side effects.

Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of duck viral hepatitis, by following component by weight mixed preparing form: Herba Pimpinellae thellungianae 15-45 part, Borneolum Syntheticum 10-50 part, Herba Aristolochiae Mollissimae 15-45 part, Radix Stephaniae Tetrandrae 15-35 part, Radix Saposhnikoviae 20-50 part, Radix Glycyrrhizae 15-45 part, Flos Carthami 20-45 part, Fructus Hordei Germinatus 20-40 part, Radix Hedysari 15-55 part, Fructus Galangae 15-45 part, Radix Polygalae 15-45 part, Halloysitum Rubrum 15-45 part.

Described various component optimum ratio amount is: Herba Pimpinellae thellungianae 30 parts, Borneolum Syntheticum 30 parts, Herba Aristolochiae Mollissimae 30 parts, Radix Stephaniae Tetrandrae 25 parts, Radix Saposhnikoviae 35 parts, 30 parts, Radix Glycyrrhizae, 30 parts, Flos Carthami, 30 parts, Fructus Hordei Germinatus, Radix Hedysari 35 parts, Fructus Galangae 30 parts, Radix Polygalae 30 parts, Halloysitum Rubrum 30 parts.

Treat a preparation method for the pure Chinese medicine composition of duck viral hepatitis, carry out as follows:

(1) 500 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Herba Pimpinellae thellungianae 15-45 part, Borneolum Syntheticum 10-50 part, Herba Aristolochiae Mollissimae 15-45 part, Radix Stephaniae Tetrandrae 15-35 part, Radix Saposhnikoviae 20-50 part, Radix Glycyrrhizae 15-45 part by weight, mix 5-10 minute to even;

(3) take Flos Carthami 20-45 part, Fructus Hordei Germinatus 20-40 part, Radix Hedysari 15-55 part, Fructus Galangae 15-45 part, Radix Polygalae 15-45 part, Halloysitum Rubrum 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

The medicinal property of each component is as follows:

Herba Pimpinellae thellungianae: pungent, warm, GUIXIN, spleen channel, have warming middle-JIAO and strengthening the spleen, a function that tonifying YANG is promoted the sexual maturity; Cure mainly shortness of breath and fatigue, cough, piglet pujos blancos, the atrophic debility of bones, infertile etc.

Borneolum Syntheticum: bitter, pungent, be slightly cold, GUIXIN, spleen, lung meridian, have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, cataract, sore swollen toxin etc.

Herba Aristolochiae Mollissimae: pungent, bitter, flat, returns liver, kidney channel, has the function of dispelling, collateral-activating, promoting the circulation of QI to relieve pain; Cure mainly rheumatic arthralgia, tripe abdomen pain etc.

Radix Stephaniae Tetrandrae: bitter, cold, returns bladder, lung meridian, has the function of inducing diuresis to remove edema, wind-expelling pain-stopping; Cure mainly difficulty in urination, edema, rheumatic arthralgia, arthralgia etc.

Radix Saposhnikoviae: pungent, sweet, warm, returns bladder, liver, spleen channel, has inducing diaphoresis to dispel wind, wins function that is wet, spasmolytic; Cure mainly affection of exogenous wind-cold, anemofrigid-damp arthralgia, rubella pruritus, tetanus etc.

Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

Flos Carthami: pungent, warm, GUIXIN, Liver Channel, have invigorate blood circulation, dissipating blood stasis, pain relieving function; Cure mainly traumatic injury, congestion pain, placenta retention, lochiorrhea etc.

Fructus Hordei Germinatus: sweet, flat, returns spleen, stomach warp, has the function of spleen benefiting and stimulating the appetite, promote qi circulation digestion promoting, galactopoiesis; Cure mainly that food stagnation does not disappear, tripe is swollen, distending pain of the breast, female animal ablactation etc.

Radix Hedysari: sweet, warm, returns spleen, lung meridian, has the function of invigorating QI to consolidate the body surface resistance, holder skin ulcer granulation promoting, inducing diuresis to remove edema; Cure mainly invigorating QI to consolidate the body surface resistance, diarrhea due to hypofunction of the spleen, skin infection difficulty burst, sinking of QI of middle-JIAO, chronic dysentery, proctoptosis, uterine prolapse, vaginocele, edema etc.

Fructus Galangae: pungent, warm, returns spleen, lung meridian, has dampness cold expelling, a function helped digestion of being amusing; Cure mainly Deficiency and coldness of spleen and stomach, have loose bowels, cold type of pain, dyspeptic abdominal distention etc.

Radix Polygalae: acrid, bitter, warm, returns kidney, the heart, lung meridian, has the function of calming the nerves, eliminating the phlegm, subsiding a swelling; Cure mainly have a guilty conscience terrified, cough with copious phlegm, sore swollen toxin etc.

Halloysitum Rubrum: sweet, puckery, sour, warm, returns large intestine, stomach warp, has the function of relieving diarrhea with astringents, hemostasis, promoting tissue regeneration and ulcer healing; Cure mainly chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, skin infection do not hold back.

All taste Chinese medicine is according to Chinese medical theory compatible combination above, for clinical symptoms and the pathological change of duck viral hepatitis, plays the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition no drug residue, have no drug resistance, cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment duck viral hepatitis, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)

(1) 500 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Herba Pimpinellae thellungianae 150 parts, Borneolum Syntheticum 100 parts, Herba Aristolochiae Mollissimae 150 parts, Radix Stephaniae Tetrandrae 150 parts, Radix Saposhnikoviae 200 parts, 150 parts, Radix Glycyrrhizae by weight, mix 5-10 minute to even;

(3) take 200 parts, Flos Carthami, 200 parts, Fructus Hordei Germinatus, Radix Hedysari 150 parts, Fructus Galangae 150 parts, Radix Polygalae 150 parts, Halloysitum Rubrum 150 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)

(1) 500 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Herba Pimpinellae thellungianae 300 parts, Borneolum Syntheticum 300 parts, Herba Aristolochiae Mollissimae 300 parts, Radix Stephaniae Tetrandrae 250 parts, Radix Saposhnikoviae 350 parts, 300 parts, Radix Glycyrrhizae by weight, mix 5-10 minute to even;

(3) take 300 parts, Flos Carthami, 300 parts, Fructus Hordei Germinatus, Radix Hedysari 350 parts, Fructus Galangae 300 parts, Radix Polygalae 300 parts, Halloysitum Rubrum 300 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)

(1) 500 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Herba Pimpinellae thellungianae 450 parts, Borneolum Syntheticum 500 parts, Herba Aristolochiae Mollissimae 450 parts, Radix Stephaniae Tetrandrae 350 parts, Radix Saposhnikoviae 500 parts, 450 parts, Radix Glycyrrhizae by weight, mix 5-10 minute to even;

(3) take 450 parts, Flos Carthami, 400 parts, Fructus Hordei Germinatus, Radix Hedysari 550 parts, Fructus Galangae 450 parts, Radix Polygalae 450 parts, Halloysitum Rubrum 450 parts by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.

Clinical trial:

Clinical experiment animal selects 20 ages in days, body weight at 1.2kg-1.3kg, and Laboratory Diagnosed is the ill meat duck of duck viral hepatitis.Ill duck isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 100,3 groups of feeding environments are identical, and experimental period carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Present composition group can by product of the present invention (compositions obtained by the embodiment of the present invention 2) the ill duck of feeding etc., day dose be: by the every 100g of the present invention, spice 220kg feeds, and drinking-water 400kg, every day 2-3 time, is used in conjunction 5; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%, at the end of have symptom rate=have symptom number of animals/experimental animal number × 100%.Following table is the result at the end of experiment.

Efficacy assessment standard:

Cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, breathes normal, bouncing, cuts open inspection liver, heart etc. normal.

At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.

Table is that the Field information situation that the present invention and other medicines treat duck viral hepatitis contrasts:

Numbering	Group	Mortality rate %	Cure rate %	At the end of have symptom rate %
					Ⅰ	Blank group	30	0	70

Ⅱ	Duck poison health is fallen apart group	10	76	14
					Ⅲ	Chinese medicine composition group of the present invention	7	86	7

This clinical trial results statistical analysis, present composition group and duck poison health fall apart group in cure rate compared with difference extremely significantly (P < 0.01).

Safety testing:

Choose the healthy meat-type duck 60 of 20 ages in days, 10 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed 10 days, during medication, healthy duck is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.

Above-mentioned detailed description of pure Chinese medicine composition of this treatment duck viral hepatitis and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.

Claims (3)

1. treat a pure Chinese medicine composition for duck viral hepatitis, it is characterized in that by following component by weight mixed preparing form: Herba Pimpinellae thellungianae 15-45 part, Borneolum Syntheticum 10-50 part, Herba Aristolochiae Mollissimae 15-45 part, Radix Stephaniae Tetrandrae 15-35 part, Radix Saposhnikoviae 20-50 part, Radix Glycyrrhizae 15-45 part, Flos Carthami 20-45 part, Fructus Hordei Germinatus 20-40 part, Radix Hedysari 15-55 part, Fructus Galangae 15-45 part, Radix Polygalae 15-45 part, Halloysitum Rubrum 15-45 part.

2. the pure Chinese medicine composition for the treatment of duck viral hepatitis according to claim 1, is characterized in that described various component optimum ratio amount is: Herba Pimpinellae thellungianae 30 parts, Borneolum Syntheticum 30 parts, Herba Aristolochiae Mollissimae 30 parts, Radix Stephaniae Tetrandrae 25 parts, Radix Saposhnikoviae 35 parts, 30 parts, Radix Glycyrrhizae, 30 parts, Flos Carthami, 30 parts, Fructus Hordei Germinatus, Radix Hedysari 35 parts, Fructus Galangae 30 parts, Radix Polygalae 30 parts, Halloysitum Rubrum 30 parts.

3. a preparation method for the pure Chinese medicine composition for the treatment of duck viral hepatitis according to claim 1 and 2, is characterized in that carrying out as follows:

(1) 500 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;

(2) take Herba Pimpinellae thellungianae 15-45 part, Borneolum Syntheticum 10-50 part, Herba Aristolochiae Mollissimae 15-45 part, Radix Stephaniae Tetrandrae 15-35 part, Radix Saposhnikoviae 20-50 part, Radix Glycyrrhizae 15-45 part by weight, mix 5-10 minute to even;

(3) take Flos Carthami 20-45 part, Fructus Hordei Germinatus 20-40 part, Radix Hedysari 15-55 part, Fructus Galangae 15-45 part, Radix Polygalae 15-45 part, Halloysitum Rubrum 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.