CN103520636A - Pure traditional Chinese medicine composition for treatment of duck virus hepatitis and preparation method thereof - Google Patents
Pure traditional Chinese medicine composition for treatment of duck virus hepatitis and preparation method thereof Download PDFInfo
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- CN103520636A CN103520636A CN201310474159.2A CN201310474159A CN103520636A CN 103520636 A CN103520636 A CN 103520636A CN 201310474159 A CN201310474159 A CN 201310474159A CN 103520636 A CN103520636 A CN 103520636A
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Abstract
The invention relates to a pure traditional Chinese medicine composition for treatment of duck virus hepatitis, and a specific preparation method of the pure traditional Chinese medicine composition comprises the following steps: (1) all components in the prescription are respectively superfinely crushed, then passes through a 500 mesh sieve, (2) weighing, by weight, 15-25 parts of poria cocos, 10-20 parts of polygala tenuifolia, 15-25 parts of barbary wolfberry fruit, 15-25 parts of radix paeoniae alba and 10-20 parts of eucommia ulmoides, mixing for 5-10 minutes to even; (3) weighing, by weight, 15-35 parts of licorice, 20-35 parts of agastache, 20-40 parts of malt, 15-30 parts of radix curcumae and 15-30 parts of carbonized hair, mixing for 5-10 minutes to even; (4) merging compositions prepared by the step (2) and (3), continuing to mix for 10-15 minutes to uniform. The beneficial effects of the pure traditional Chinese medicine composition are that: the prescription is reasonable, the preparation is simple, the pure traditional Chinese medicine composition has no toxic and side effect, no drug residue and no drug resistance, is superfinely crushed, and has high bioavailability and obvious curative effects, and clinic proofs that the pure traditional Chinese medicine composition has specific effects on treatment of the duck virus hepatitis.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment duck viral hepatitis and preparation method thereof.
Background technology
Duck viral hepatitis is a kind of common acute, the height lethal infectious disease being caused by DHV, 2 week age of main infection is with interior duckling, take clinically opisthotonus, beak end and pawl point congestion and be mulberry as feature, cut open the visible liver enlargement of inspection and have a large amount of hemorrhagic speckles, mortality rate is very high, is one of principal disease of the foster duck industry of harm.
The pathogen of primary disease is DHV, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral Western medicine ban use of as ribavirin, the amantadine Deng， Ministry of Agriculture.
Therefore researching and developing a kind of specific medicament for the treatment of duck viral hepatitis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the pure Chinese medicine composition of effective treatment duck viral hepatitis of toxic and side effects and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of duck viral hepatitis, by following component by weight mixed preparing form: Poria cum Radix Pini 15-25 part, Radix Polygalae 10-20 part, Fructus Lycii 15-25 part, Radix Paeoniae Alba 15-25 part, Cortex Eucommiae 10-20 part, Radix Glycyrrhizae 15-35 part, Herba Pogostemonis 20-35 part, Fructus Hordei Germinatus 20-40 part, Radix Curcumae 15-30 part, Crinis Carbonisatus 15-30 part.
Described various component optimum ratio amount is: 20 parts of Poria cum Radix Pinis, 15 parts of Radix Polygalaes, 20 parts of Fructus Lycii, 20 parts of the Radix Paeoniae Albas, 15 parts of the Cortexs Eucommiae, 25 parts, Radix Glycyrrhizae, 25 parts of Herba Pogostemoniss, 30 parts, Fructus Hordei Germinatus, 20 parts of Radix Curcumaes, 20 parts of Crinis Carbonisatus.
A preparation method for the pure Chinese medicine composition of duck viral hepatitis, carry out as follows:
(1) the various compositions in prescription are crossed to 500 mesh sieves after micronizing respectively;
(2) take by weight Poria cum Radix Pini 15-25 part, Radix Polygalae 10-20 part, Fructus Lycii 15-25 part, Radix Paeoniae Alba 15-25 part, Cortex Eucommiae 10-20 part, mix 5-10 minute to even;
(3) take by weight Radix Glycyrrhizae 15-35 part, Herba Pogostemonis 20-35 part, Fructus Hordei Germinatus 20-40 part, Radix Curcumae 15-30 part, blood She charcoal 15-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Poria cum Radix Pini: sweet, flat, GUIXIN, spleen channel, have the function of mind tranquilizing and the heart calming; Cure mainly terrified, the coma of having a guilty conscience, difficulty in urination etc.
Radix Polygalae: bitter, warm, return liver, stomach warp, there is the function of tranquilizing by nourishing the heart, relieving cough and reducing sputum; Cure mainly terrified, the nervous insufficiency of the spleen cough etc. of having a guilty conscience.
Fructus Lycii: sweet, flat, return liver, kidney channel, there is the function of nourishing the liver and kidney, replenishing vital essence to improve eyesight; Cure mainly lumbago due to renal deficiency, deficiency of the liver blurred vision, myasthenia of limbs etc.
The Radix Paeoniae Alba: bitter, acid, cold, return liver, stomach warp, there is the function of hemopoietic removing heat from blood, nourishing the liver strengthening the spleen; Cure mainly blood deficiency, blood stasis, enteritis, hematuria, tire all diseases in front puerperal etc.
The Cortex Eucommiae: sweet, warm, return liver, kidney channel, there is the function of temperature compensation Liver and kidney, bone and muscle strengthening; Cure mainly cold hinder waist hip, extremity rheumatism, positive thin spermatorrhea, frequent fetal movement etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Herba Pogostemonis: pungent, warm, return spleen, stomach warp, there is the function that dispelling wind to relieve the exterior syndrome, circulation of qi promoting removing dampness, stomach function regulating are amusing; Cure mainly that heat-damp in summer heating, cold intestinal are had loose bowels, edema etc.
Fructus Hordei Germinatus: sweet, flat, return spleen, stomach warp, the function that there is strengthening the spleen to promote digestion, parasite killing, galactopoiesis, expedites the emergence of; Cure mainly that grass of last year does not disappear, insufficiency of the spleen stomach is weak, placenta retention, malnutrition due to parasitic infestation etc.
Radix Curcumae: pungent, bitter, cold, return liver, the heart, lung meridian, there is the function of promoting QI circulation for relieving depression, promoting blood circulation and breaking stagnation; Cure mainly epistaxis, have blood in stool, hematuria, puerperal abdonimal pain, acute enteritis, skin ulcer Huang toxic swelling etc.
Crinis Carbonisatus: bitter, flat, return liver, stomach warp, there is the function that skin ulcer is closed in hemostasis, granulation promoting; Cure mainly various hemorrhage etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for clinical symptoms and the pathological change of duck viral hepatitis, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition no drug residue, have no drug resistance, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment duck viral hepatitis is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 500 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Poria cum Radix Pinis, 100 parts of Radix Polygalaes, 150 parts of Fructus Lycii, 150 parts of the Radix Paeoniae Albas, 100 parts of the Cortexs Eucommiae, mix 5-10 minute to even;
(3) take by weight 150 parts, Radix Glycyrrhizae, 200 parts of Herba Pogostemoniss, 200 parts, Fructus Hordei Germinatus, 150 parts of Radix Curcumaes, 150 parts of Crinis Carbonisatus, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 500 mesh sieves after micronizing respectively;
(2) take by weight 200 parts of Poria cum Radix Pinis, 150 parts of Radix Polygalaes, 200 parts of Fructus Lycii, 200 parts of the Radix Paeoniae Albas, 150 parts of the Cortexs Eucommiae, mix 5-10 minute to even;
(3) take by weight 250 parts, Radix Glycyrrhizae, 250 parts of Herba Pogostemoniss, 300 parts, Fructus Hordei Germinatus, 250 parts of Radix Curcumaes, 200 parts of Crinis Carbonisatus, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 500 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Poria cum Radix Pinis, 200 parts of Radix Polygalaes, 250 parts of Fructus Lycii, 250 parts of the Radix Paeoniae Albas, 200 parts of the Cortexs Eucommiae, mix 5-10 minute to even;
(3) take by weight 350 parts, Radix Glycyrrhizae, 350 parts of Herba Pogostemoniss, 400 parts, Fructus Hordei Germinatus, 300 parts of Radix Curcumaes, 300 parts of Crinis Carbonisatus, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 20-30 age in days, body weight at 1.2kg-1.5kg, the ill meat duck that Laboratory Diagnosed is duck viral hepatitis.Ill duck isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Present composition group can be by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill duck of feeding etc., and a day dose is: by the every 100g of the present invention, spice 220kg feeds, and drinking-water 400kg, is used in conjunction 3-5 day at every day 2-3 time; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 7th day) when following table is experiment end.
Efficacy assessment standard:
Cure: spiritual normal, the drinking-water of searching for food is normal, and feces is normal, breathe normally, bouncing, cuts open inspection liver, heart etc. normal.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment duck viral hepatitis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 31 | 23 | 46 |
| II | The loose group of duck poison health | 11 | 75 | 14 |
| III | Chinese medicine composition group of the present invention | 7 | 86 | 7 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P < 0.01) with the loose group of duck poison health aspect cure rate.
Safety testing:
Choose 60 of the healthy meat-type duck of 20 ages in days, 10 times of spices according to the made compositions recommended dose of the embodiment of the present invention 2 are fed 10 days, during medication, healthy duck is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment duck viral hepatitis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for duck viral hepatitis, it is characterized in that by following component by weight mixed preparing form: Poria cum Radix Pini 15-25 part, Radix Polygalae 10-20 part, Fructus Lycii 15-25 part, Radix Paeoniae Alba 15-25 part, Cortex Eucommiae 10-20 part, Radix Glycyrrhizae 15-35 part, Herba Pogostemonis 20-35 part, Fructus Hordei Germinatus 20-40 part, Radix Curcumae 15-30 part, Crinis Carbonisatus 15-30 part.
2. the pure Chinese medicine composition for the treatment of duck viral hepatitis according to claim 1, is characterized in that described various component optimum ratio amount is: 20 parts of Poria cum Radix Pinis, 15 parts of Radix Polygalaes, 20 parts of Fructus Lycii, 20 parts of the Radix Paeoniae Albas, 15 parts of the Cortexs Eucommiae, 25 parts, Radix Glycyrrhizae, 25 parts of Herba Pogostemoniss, 30 parts, Fructus Hordei Germinatus, 20 parts of Radix Curcumaes, 20 parts of Crinis Carbonisatus.
3. a preparation method for the pure Chinese medicine composition for the treatment of duck viral hepatitis according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 500 mesh sieves after micronizing respectively;
(2) take by weight Poria cum Radix Pini 15-25 part, Radix Polygalae 10-20 part, Fructus Lycii 15-25 part, Radix Paeoniae Alba 15-25 part, Cortex Eucommiae 10-20 part, mix 5-10 minute to even;
(3) take by weight Radix Glycyrrhizae 15-35 part, Herba Pogostemonis 20-35 part, Fructus Hordei Germinatus 20-40 part, Radix Curcumae 15-30 part, Crinis Carbonisatus 15-30 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN201310474159.2A CN103520636A (en) | 2013-09-27 | 2013-09-27 | Pure traditional Chinese medicine composition for treatment of duck virus hepatitis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606646A (en) * | 2015-02-14 | 2015-05-13 | 安徽恒源药业有限公司 | Special antiviral traditional Chinese medicine preparation capable of increasing feed intake for laying ducks |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1454661A (en) * | 2003-05-30 | 2003-11-12 | 刘梅英 | Medicine for curing hepatitis B and preparing method thereof |
| KR20130019725A (en) * | 2011-08-17 | 2013-02-27 | 전남대학교산학협력단 | A pharmaceutical composition comprising the fractions of water extract from curcuma longa l. for preventing alcoholic liver damage |
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2013
- 2013-09-27 CN CN201310474159.2A patent/CN103520636A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1454661A (en) * | 2003-05-30 | 2003-11-12 | 刘梅英 | Medicine for curing hepatitis B and preparing method thereof |
| KR20130019725A (en) * | 2011-08-17 | 2013-02-27 | 전남대학교산학협력단 | A pharmaceutical composition comprising the fractions of water extract from curcuma longa l. for preventing alcoholic liver damage |
Non-Patent Citations (1)
| Title |
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| 张洪泉等: "参灵益肝颗粒抗乙型肝炎病毒作用的实验研究", 《中国中西医结合杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606646A (en) * | 2015-02-14 | 2015-05-13 | 安徽恒源药业有限公司 | Special antiviral traditional Chinese medicine preparation capable of increasing feed intake for laying ducks |
| CN104606646B (en) * | 2015-02-14 | 2018-05-04 | 安徽恒源药业有限公司 | A kind of laying duck is special antiviral and improves the Chinese medicine preparation of feed intake |
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Application publication date: 20140122 |
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