CN103599220A - Compound propolis composition for treating pet acariasis disease, and preparation method thereof - Google Patents
Compound propolis composition for treating pet acariasis disease, and preparation method thereof Download PDFInfo
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- CN103599220A CN103599220A CN201310581634.6A CN201310581634A CN103599220A CN 103599220 A CN103599220 A CN 103599220A CN 201310581634 A CN201310581634 A CN 201310581634A CN 103599220 A CN103599220 A CN 103599220A
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Abstract
The invention relates to a compound propolis composition for treating a pet acariasis disease. The compound propolis composition is prepared from the following components in parts by weight: 15-35 parts of propolis, 15-35 parts of radix angelicae pubescentis, 15-35 parts of radices ligustici sinensis, 15-40 parts of radices trichosanthis, 15-45 parts of spina date seed, 15-35 parts of uncaria rhynchophylla, 15-35 parts of teasel root, 15-35 parts of hawthorn, 15-35 parts of sanguisorba officinalis, 15-35 parts of carbonized hair, 15-55 parts of quispualis indica and 15-35 parts of common carpesium fruit in a mixing manner. The compound propolis composition has the beneficial effects of being reasonable in prescription, simple in preparation, free of toxic and side effects, free of pollution, free of drug residue, free of drug tolerance, ultramicro in crushing, high in bioavailability, and significant in curative effect. A clinical test proves that the compound propolis composition has special efficiency on treatment of the pet acariasis disease.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment house pet mange and scab and preparation method thereof.
Background technology
House pet mange and scab is a kind of height contagious infection dermatoses being caused by acaricide, and itch all over and the affected part depilation of take is feature.House pet infects this disease, often occurs that symptom, the bodies such as play is itched, depilation become thin gradually, affect growth promoter, more do not cause death for a long time, causes very large economic loss to house pet industry.
The traditional Chinese medical science thinks that this disease belongs to exopathogen invading into the interior, the damp and hot skin of fighting mutually, and due to QI and blood is weak, treatment should adopt heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, remove that wind is antipruritic, the principle of cool blood and remove dampness, strengthening vital QI to eliminate pathogenic factors.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm house pet industry.
This disease almost spreads all over the world all livestock culturings country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And western medical treatment mainly be take sterilization, antiinflammatory etc. as main, Western medicine is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, and clinical practice is very limited.
Therefore research and develop that a kind of to treat the having no side effect of house pet mange and scab, drug residue free, the specific medicament producing that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment house pet mange and scab of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of house pet mange and scab, by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part.
Described various component optimum ratio amount is: 25 parts of propolis, 25 parts of Radix Angelicae Pubescentiss, 25 parts of Rhizoma Ligusticis, 30 parts of Radix Trichosanthis, 30 parts of Semen Ziziphi Spinosaes, 25 parts of Ramulus Uncariae Cum Uncis, 25 parts of Radix Dipsacis, 25 parts of Fructus Crataegis, 25 parts of Radix Sanguisorbaes, 25 parts of Crinis Carbonisatus, 35 parts of Fructus Quisqualis, 25 parts of Fructus Carpesiis.
Treat a preparation method for the compound bee-glue composition of house pet mange and scab, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa etc.
Radix Angelicae Pubescentis: bitter, be slightly cold, return lung, kidney, spleen channel, there is the function of nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, QI invigorating, clearing away heat and cooling blood; Cure mainly lung-heat cough with asthma, consumption of YIN caused by febrile disease, carbuncle sore tumefacting virus, scabies etc.
Rhizoma Ligustici: pungent, warm, return urinary bladder channel, have dispel the wind, the function of cold expelling, dehumidifying, pain relieving; Cure mainly that anemofrigid-damp arthralgia, waist hip swell and ache, tetanus etc.
Radix Trichosanthis: sweet, bitter, cold, attach to the lung and stomach meridians, there is the function of clearing away heat and promoting production of body fluid, detumescence and apocenosis, relieving cough and resolving phlegm; Cure mainly that calentura excessive thirst, lung-heat type cough, interior-heat are quenched one's thirst, sore swollen toxin etc.
Semen Ziziphi Spinosae: sweet, sour, flat, return liver, the heart, spleen, gallbladder meridian, having that centering is calmed the nerves, a function of tonifying liver gallbladder, arresting sweating; Cure mainly terrified, the spontaneous sweating of having a guilty conscience etc.
Ramulus Uncariae Cum Uncis: sweet, cold, return liver, heart channel, there is the function relieving convulsion, heat clearing away suppressing the hyperactive liver that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; Cure mainly that infantile convulsion, conjunctival congestion and swelling pain, mouthful mouth are crooked, tetanus etc.
Radix Dipsaci: warm, pungent, bitter, return liver, kidney channel, there is the function in invigorating the liver and kidney, reuniting the fractured tendons and bones, promoting blood circulation, sharp joint; Cure mainly muscles and bones fractureing, traumatic injury, rheumatic arthralgia, frequent fetal movement, carbuncle and ulcer treatment poison etc.
Fructus Crataegi: warm, sweet, sour, return liver, stomach, spleen channel, there is removing food stagnancy, clots absorbing, the stagnant function of change; Cure mainly that dyspepsia, insufficiency of the spleen stomach are weak, constipation or stagnant have loose bowels etc.
Radix Sanguisorbae: bitter, acid, cold, return stomach, liver, kidney, lung meridian, there is cooling blood for hemostasis, heat-clearing and toxic substances removing, the function of detumescence sore; Cure mainly dysentery, have blood in stool, generate heat etc. after hematuria, burn.
Crinis Carbonisatus: bitter, tepor, return stomach, liver, kidney channel, there is the function of hemostasis, blood stasis dispelling, diuresis, granulation promoting; Cure mainly various hemorrhage etc.
Fructus Quisqualis: sweet, warm, return large intestine, stomach, spleen channel, there is the function of anthelmintic, spleen invigorating removing food stagnancy; Cure mainly ascarid, scabies etc.
Fructus Carpesii: bitter, flat, return liver, stomach, spleen channel, there is the function of parasite killing, heat-clearing and toxic substances removing, invigorating the spleen and regulating the stomach; Cure mainly gastrointestinal parasite, external mange and scab etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of house pet mange and scab, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this 12 taste Chinese medicine, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment house pet mange and scab is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Radix Angelicae Pubescentiss, 150 parts of Rhizoma Ligusticis, 150 parts of Radix Trichosanthis, 150 parts of Semen Ziziphi Spinosaes, 150 parts of Ramulus Uncariae Cum Uncis, mix 5-10 minute to even;
(3) take by weight 150 parts of Radix Dipsacis, 150 parts of Fructus Crataegis, 150 parts of Radix Sanguisorbaes, 150 parts of Crinis Carbonisatus, 150 parts of Fructus Quisqualis, 150 parts of Fructus Carpesiis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 250 parts of Radix Angelicae Pubescentiss, 250 parts of Rhizoma Ligusticis, 300 parts of Radix Trichosanthis, 300 parts of Semen Ziziphi Spinosaes, 250 parts of Ramulus Uncariae Cum Uncis, mix 5-10 minute to even;
(3) take by weight 250 parts of Radix Dipsacis, 250 parts of Fructus Crataegis, 250 parts of Radix Sanguisorbaes, 250 parts of Crinis Carbonisatus, 350 parts of Fructus Quisqualis, 250 parts of Fructus Carpesiis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 350 parts of Radix Angelicae Pubescentiss, 350 parts of Rhizoma Ligusticis, 400 parts of Radix Trichosanthis, 450 parts of Semen Ziziphi Spinosaes, 350 parts of Ramulus Uncariae Cum Uncis, mix 5-10 minute to even;
(3) take by weight 350 parts of Radix Dipsacis, 350 parts of Fructus Crataegis, 350 parts of Radix Sanguisorbaes, 350 parts of Crinis Carbonisatus, 550 parts of Fructus Quisqualis, 350 parts of Fructus Carpesiis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The ill capital bar dog that it is mange and scab that clinical experiment animal is selected 100-180 age in days, Laboratory Diagnosed.Ill dog isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, 30 every group, 3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and institute's control drug for medicine matched group " " Jiexuanling " medicine for treating scabies is loose " by specification is used treatment; Chinese medicine composition group of the present invention can brew product of the present invention (the prepared compositions of the embodiment of the present invention 2) with boiled water, wait temperature and gavage, and once a day, each 100 grams-250 grams, is used in conjunction 5-7 days.After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result when following table is experiment end.
Efficacy assessment standard:
Cure: spirit is normal, the drinking-water of searching for food is normal, and feces is normal, and body temperature is normal, skin is normal etc.The pathogenic microorganisms such as acaricide are not found at the positions such as laboratory detection of skin.
During end, there is symptom: clinical symptoms is not improved and even increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment dog mange and scab:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 10 | 13.3 | 76.7 |
| II | The " Jiexuanling " medicine for treating scabies group of faling apart | 6.7 | 76.7 | 16.6 |
| III | Present composition group | 3.3 | 86.7 | 10 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P < 0.01) with the loose group of " Jiexuanling " medicine for treating scabies aspect cure rate.
Safety testing:
Choose 10 of 2 monthly age healthy dogs, wait temperature gavage 10 days according to 5 times of the made compositions recommended dose of the embodiment of the present invention 2, during medication, observation experiment dog is without any bad or Deviant Behavior performance, and the drinking-water of searching for food is normal.
Above-mentioned detailed description of compound bee-glue composition of this treatment house pet mange and scab and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for house pet mange and scab, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part.
2. the compound bee-glue composition for the treatment of house pet mange and scab according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of propolis, 25 parts of Radix Angelicae Pubescentiss, 25 parts of Rhizoma Ligusticis, 30 parts of Radix Trichosanthis, 30 parts of Semen Ziziphi Spinosaes, 25 parts of Ramulus Uncariae Cum Uncis, 25 parts of Radix Dipsacis, 25 parts of Fructus Crataegis, 25 parts of Radix Sanguisorbaes, 25 parts of Crinis Carbonisatus, 35 parts of Fructus Quisqualis, 25 parts of Fructus Carpesiis.
3. a preparation method for the compound bee-glue composition for the treatment of according to claim 1 and 2 house pet mange and scab, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, mix 5-10 minute to even;
(3) take by weight Radix Dipsaci 15--35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310581634.6A CN103599220B (en) | 2013-11-12 | 2013-11-12 | Compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877326A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating acariasis of domestic animals and preparation method thereof |
| WO2017010858A1 (en) * | 2015-07-15 | 2017-01-19 | Flores Samaniego Beatriz | Composition based on extracts of heliopsis longipes and propolis for the control and/or elimination of ticks |
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| CN101278943A (en) * | 2008-05-19 | 2008-10-08 | 郝天好 | Externally-applied medicine for curing psora and preparation method thereof |
| KR20090026426A (en) * | 2007-09-10 | 2009-03-13 | 주식회사 엘지생활건강 | Composition for moisturizing and improving wrinkle on skin |
| CN102784350A (en) * | 2012-08-07 | 2012-11-21 | 孙雅儒 | Mite killing bactericide and preparation method of mite killing bactericide |
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2013
- 2013-11-12 CN CN201310581634.6A patent/CN103599220B/en not_active Expired - Fee Related
Patent Citations (4)
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| KR20090026426A (en) * | 2007-09-10 | 2009-03-13 | 주식회사 엘지생활건강 | Composition for moisturizing and improving wrinkle on skin |
| CN101204529A (en) * | 2007-12-18 | 2008-06-25 | 秦庆吉 | Medicine for wound-curing and scar-dispeling |
| CN101278943A (en) * | 2008-05-19 | 2008-10-08 | 郝天好 | Externally-applied medicine for curing psora and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877326A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating acariasis of domestic animals and preparation method thereof |
| WO2017010858A1 (en) * | 2015-07-15 | 2017-01-19 | Flores Samaniego Beatriz | Composition based on extracts of heliopsis longipes and propolis for the control and/or elimination of ticks |
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| CN103599220B (en) | 2015-07-29 |
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