CN103877326A - Traditional Chinese medicine composition for treating acariasis of domestic animals and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating acariasis of domestic animals and preparation method thereof Download PDFInfo
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- CN103877326A CN103877326A CN201410112254.2A CN201410112254A CN103877326A CN 103877326 A CN103877326 A CN 103877326A CN 201410112254 A CN201410112254 A CN 201410112254A CN 103877326 A CN103877326 A CN 103877326A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating acariasis of domestic animals. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-55 parts of cirsii japonici herba carbonisata, 15-35 parts of pericarpium arece, 15-55 parts of subprostrate sophora, 15-45 parts of Chinese yam, 15-45 parts of hawthorn, 15-55 parts of homalomena occulta, 15-65 parts of moleplant seed, 15-35 parts of medicinal cyathula root, 15-45 parts of astragalus membranaceus, 15-55 parts of euphorbia hirta, 15-55 parts of szechwan chinaberry fruit and 15-75 parts of fructus choerospondiatis. The traditional Chinese medicine composition has the beneficial effects that the components are reasonable, the preparation is simple, the composition is free of toxic or side effect, free of pollution, free of medicine residue, free of medicine resistance, high in bioavailability and remarkable in curative effect, and can be crushed in a superfine manner, and the clinical application shows that the composition is especially effective in treating acariasis of domestic animals.
Description
Technical field
The present invention relates to Chinese medicine composition for the treatment of acariasis of domestic animal and preparation method thereof, belong to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment acariasis of domestic animal and preparation method thereof.
Background technology
Acariasis of domestic animal is a kind of height contagious infection dermatoses being caused by acaricide, loses hair or feathers as feature take itch all over and affected part.This disease of animal infection, often occurs that symptom, the bodies such as play is itched, depilation become thin gradually, affect growth promoter, more do not cause death for a long time, causes very large economic loss to animal raising.
The traditional Chinese medical science thinks that this disease belongs to exopathogen invading into the interior, the damp and hot skin of fighting mutually, and due to QI and blood is weak, treatment should adopt heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, remove that wind is antipruritic, the principle of cool blood and remove dampness, strengthening vital QI to eliminate pathogenic factors.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm livestock culturing industry.
This disease almost spreads all over all livestock culturings country of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And western medical treatment is mainly take sterilization, antiinflammatory etc. as main, Western medicine is because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, and clinical practice is very limited.
Therefore research and develop and a kind ofly treat the having no side effect of acariasis of domestic animal, drug residue free, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the Chinese medicine composition of effective treatment acariasis of domestic animal of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of acariasis of domestic animal, by following component by weight mixed preparing form: Carbonized Cirsium japonicum 15-55 part, Pericarpium Arecae 15-35 part, Radix Sophorae Tonkinensis 15-55 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-45 part, Rhizoma Homalomenae 15-55 part, Semen Euphorbiae 15-65 part, Radix Cyathulae 15-35 part, Radix Astragali 15-45 part, Ramulus et Folium Bauhiniae Faberi 15-55 part, Fructus Toosendan 15-55 part, Fructus Choerospondiatis 15-75 part.
Described various component optimum ratio amount is: 35 parts of Carbonized Cirsium japonicum, 25 parts of Pericarpium Arecae, 35 parts of Radix Sophorae Tonkinensiss, 30 parts of Rhizoma Dioscoreaes, 30 parts of Fructus Crataegis, 35 parts of Rhizoma Homalomenaes, 40 parts of Semen Euphorbiaes, 25 parts of Radix Cyathulaes, 30 parts of the Radixs Astragali, 35 parts of Ramulus et Folium Bauhiniae Faberi, 35 parts of Fructus Toosendans, 45 parts of Fructus Choerospondiatis.
Treat a preparation method for the Chinese medicine composition of acariasis of domestic animal, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Carbonized Cirsium japonicum 15-55 part, Pericarpium Arecae 15-35 part, Radix Sophorae Tonkinensis 15-55 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-45 part, Rhizoma Homalomenae 15-55 part, mix 5-10 minute to even;
(3) take by weight Semen Euphorbiae 15-65 part, Radix Cyathulae 15-35 part, Radix Astragali 15-45 part, Ramulus et Folium Bauhiniae Faberi 15-55 part, Fructus Toosendan 15-55 part, Fructus Choerospondiatis 15-75 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Carbonized Cirsium japonicum: bitter, puckery, cool, GUIXIN, Liver Channel, have the function of cooling blood for hemostasis; Cure mainly epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage etc.
Pericarpium Arecae: pungent, tepor, return large intestine, spleen, stomach, small intestine meridian, there is the function of promoting the circulation of QI to alleviate the stagnation in middle-JIAO, line water detumescence; Cure mainly retention of damp leading to blockage of QI, edema distension, retained water and stop umbilicus, dysuria etc.
Radix Sophorae Tonkinensis: bitter, cold, attach to the lung and stomach meridians, there is the function of heat-clearing and toxic substances removing, detumescence sore-throat relieving, expelling phlegm for arresting cough; Cure mainly laryngopharynx swelling and pain, lung-heat cough with asthma, the yellow furunculosis of skin ulcer etc.
Rhizoma Dioscoreae: sweet, flat, return kidney, spleen, kidney channel, have that spleen reinforcing nourishing the stomach, lung benefiting are promoted the production of body fluid, the function of the kidney invigorating arresting seminal emission; Cure mainly weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen, asthenia cough with asthma, spermatorrhea, leukorrhagia, frequent micturition number etc.
Fructus Crataegi: sour, sweet, tepor, return spleen, stomach, Liver Channel, there is the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Rhizoma Homalomenae: bitter, pungent, warm, return kidney, Liver Channel, there is the function of dredging the meridian, loose wind damp eliminating, strong muscle symplectic bone; Cure mainly anemofrigid-damp arthralgia, muscles and bones pain, spasm of the limbs etc.
Semen Euphorbiae: pungent, warm, return large intestine, kidney, Liver Channel, there is the function of the detumescence of relieving oedema or abdominal distension through diuresis or purgation, removing blood stasis eliminating stagnation; Cure mainly difficulty in urination, ascites tripe is swollen, feces is constipated etc.
Radix Cyathulae: bitter, sweet, flat, return kidney, Liver Channel, there is the function of eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome; Cure mainly rheumatic arthralgia, puerperal blood stasis, placenta retention, traumatic injury, stranguria with blood etc.
The Radix Astragali: sweet, tepor, return lung, spleen channel, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Ramulus et Folium Bauhiniae Faberi: pungent, sour, cool, return large intestine, lung, urinary bladder channel, have that heat-clearing and toxic substances removing, dampness removing are antipruritic, the function of lactogenesis; Cure mainly lung abscess, acute mastitis, furuncle swelling toxin, have loose bowels, pyretic stranguria, hematuria, puerperal breast less, eczema etc.
Fructus Toosendan: bitter, cold, return small intestinal, liver, urinary bladder channel, there is the function of soothing the liver circulation of qi promoting, promoting the circulation of QI to relieve pain, anthelmintic; Cure mainly stagnation of QI abdominal distention, waist across pain, malnutrition due to parasitic infestation etc.
Fructus Choerospondiatis: sweet, sour, flat, GUIXIN, Liver Channel, have the function of promoting flow of QI and blood, tranquilizing by nourishing the heart; Cure mainly qi depression to blood stasis, irritability etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of acariasis of domestic animal, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this 12 taste Chinese medicine, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment acariasis of domestic animal is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition for the treatment of acariasis of domestic animal and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Carbonized Cirsium japonicum, 150 parts of Pericarpium Arecae, 150 parts of Radix Sophorae Tonkinensiss, 150 parts of Rhizoma Dioscoreaes, 150 parts of Fructus Crataegis, 150 parts of Rhizoma Homalomenaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Semen Euphorbiaes, 150 parts of Radix Cyathulaes, 150 parts of the Radixs Astragali, 150 parts of Ramulus et Folium Bauhiniae Faberi, 150 parts of Fructus Toosendans, 150 parts of Fructus Choerospondiatis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of Chinese medicine composition for the treatment of acariasis of domestic animal and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Carbonized Cirsium japonicum, 250 parts of Pericarpium Arecae, 350 parts of Radix Sophorae Tonkinensiss, 300 parts of Rhizoma Dioscoreaes, 300 parts of Fructus Crataegis, 350 parts of Rhizoma Homalomenaes, mix 5-10 minute to even;
(3) take by weight 400 parts of Semen Euphorbiaes, 250 parts of Radix Cyathulaes, 300 parts of the Radixs Astragali, 350 parts of Ramulus et Folium Bauhiniae Faberi, 350 parts of Fructus Toosendans, 450 parts of Fructus Choerospondiatis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of Chinese medicine composition for the treatment of acariasis of domestic animal and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 550 parts of Carbonized Cirsium japonicum, 350 parts of Pericarpium Arecae, 550 parts of Radix Sophorae Tonkinensiss, 450 parts of Rhizoma Dioscoreaes, 450 parts of Fructus Crataegis, 550 parts of Rhizoma Homalomenaes, mix 5-10 minute to even;
(3) take by weight 650 parts of Semen Euphorbiaes, 350 parts of Radix Cyathulaes, 450 parts of the Radixs Astragali, 550 parts of Ramulus et Folium Bauhiniae Faberi, 550 parts of Fructus Toosendans, 750 parts of Fructus Choerospondiatis, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 100-180 age in days, body weight at 20kg-45kg, and Laboratory Diagnosed is the ill sheep of sheep mange tinea.Ill sheep isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, 20 every group, 3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and medicine matched group uses treatment with " wiping scabies loose " by specification; Chinese medicine composition group of the present invention can brew product of the present invention (the prepared compositions of the embodiment of the present invention 2) with boiled water, wait temperature and gavage, and once a day, each 100 grams-250 grams, is used in conjunction 5-7 days.After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result when following table is experiment end.
Efficacy assessment standard:
Cure: spirit is normal, the drinking-water of searching for food is normal, and feces is normal, and body temperature is normal, skin is normal etc.The pathogenic microorganisms such as acaricide etc. are not found at the positions such as laboratory detection of skin.
When end, there is symptom: clinical symptoms is not improved even and increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment sheep mange tinea:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 10 | 0 | 90 |
| II | Wipe the loose group of scabies | 5 | 80 | 15 |
| III | Present composition group | 5 | 90 | 5 |
This clinical effectiveness statistical analysis, present composition treatment group with wipe the loose group of scabies extremely significantly (P < 0.01) of difference compared with aspect cure rate.
Safety testing:
Choose 10 of 1 monthly age Healthy Sheep, gavage 7 days according to 5 times of time temperature of the made compositions recommended dose of the embodiment of the present invention 2, during medication, observe and find that experiment sheep is without any bad or Deviant Behavior performance, searching for food, it is normal to drink water.
The above-mentioned detailed description that Chinese medicine composition to this treatment acariasis of domestic animal and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for acariasis of domestic animal, it is characterized in that by following component by weight mixed preparing form: Carbonized Cirsium japonicum 15-55 part, Pericarpium Arecae 15-35 part, Radix Sophorae Tonkinensis 15-55 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-45 part, Rhizoma Homalomenae 15-55 part, Semen Euphorbiae 15-65 part, Radix Cyathulae 15-35 part, Radix Astragali 15-45 part, Ramulus et Folium Bauhiniae Faberi 15-55 part, Fructus Toosendan 15-55 part, Fructus Choerospondiatis 15-75 part form.
2. the Chinese medicine composition for the treatment of acariasis of domestic animal according to claim 1, is characterized in that described various component optimum ratio amount is: 35 parts of Carbonized Cirsium japonicum, 25 parts of Pericarpium Arecae, 35 parts of Radix Sophorae Tonkinensiss, 30 parts of Rhizoma Dioscoreaes, 30 parts of Fructus Crataegis, 35 parts of Rhizoma Homalomenaes, 40 parts of Semen Euphorbiaes, 25 parts of Radix Cyathulaes, 30 parts of the Radixs Astragali, 35 parts of Ramulus et Folium Bauhiniae Faberi, 35 parts of Fructus Toosendans, 45 parts of compositions of Fructus Choerospondiatis.
3. a preparation method for the Chinese medicine composition for the treatment of acariasis of domestic animal according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Carbonized Cirsium japonicum 15-55 part, Pericarpium Arecae 15-35 part, Radix Sophorae Tonkinensis 15-55 part, Rhizoma Dioscoreae 15-45 part, Fructus Crataegi 15-45 part, Rhizoma Homalomenae 15-55 part, mix 5-10 minute to even;
(3) take by weight Semen Euphorbiae 15-65 part, Radix Cyathulae 15-35 part, Radix Astragali 15-45 part, Ramulus et Folium Bauhiniae Faberi 15-55 part, Fructus Toosendan 15-55 part, Fructus Choerospondiatis 15-75 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN201410112254.2A CN103877326A (en) | 2014-03-15 | 2014-03-15 | Traditional Chinese medicine composition for treating acariasis of domestic animals and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670939A (en) * | 2012-05-11 | 2012-09-19 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating livestock acariasis and preparation method thereof |
| CN102670863A (en) * | 2012-05-11 | 2012-09-19 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating acariasis of domestic animal and preparation method thereof |
| CN103599220A (en) * | 2013-11-12 | 2014-02-26 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating pet acariasis disease, and preparation method thereof |
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2014
- 2014-03-15 CN CN201410112254.2A patent/CN103877326A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670939A (en) * | 2012-05-11 | 2012-09-19 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating livestock acariasis and preparation method thereof |
| CN102670863A (en) * | 2012-05-11 | 2012-09-19 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating acariasis of domestic animal and preparation method thereof |
| CN103599220A (en) * | 2013-11-12 | 2014-02-26 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating pet acariasis disease, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘春雨等: "中药治疗家畜疥癣217例", 《中兽医医药杂志》 * |
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Application publication date: 20140625 |