CN103055281A - Pure Chinese medicinal composition for treating white head-mouth disease of fish and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating white head-mouth disease of fish and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the white head-mouth disease of fish. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 15 to 35 parts of lonicera japonica, 15 to 35 parts of angelica dahurica, 20 to 40 parts of dried ginger, 20 to 40 parts of licorice root, 15 to 35 parts of large-head atractylodes rhizome, 25 to 45 parts of Chinese pulsatilla root, 20 to 40 parts of pomegranate rind, 20 to 40 parts of virgate wormwood herb, 20 to 40 parts of plantain herb and 20 to 40 parts of lightyellow sophora root. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the white head-mouth disease of the fish.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of the fish white head and mouth fish disease and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment fish white head and mouth fish disease and preparation method thereof.
Background technology
The fish white head and mouth fish disease is to be infected and caused by slime bacteria, and one section skin that sick fish shows as from the kiss end to eyeball loses normal color, becomes milky.Observe the sick fish that moves about at the pool side water surface, the symptom of visible " the white mouth of hoary hair ".Sick shark's lip swelling is opened and is closed malfunctioning, dyspnea, and the skin ulceration around mouthful has floccule to adhere on it.Sick fish body is thin, and body colour is more black, swims at the leeward offshore water surface feeblely, and is extremely blunt to reactions such as people, sound, namely dead soon.This disease is one of serious plant disease of harm summer flower fingerling, and is especially very harmful to Young grass carp, already causes serious economic loss for fish culture.
This disease almost spreads all over all fish culture countries of the world, is widely distributed.The primary disease western medicine mainly uses antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of the fish white head and mouth fish disease, micronizing, bioavailability height, the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simply, micronizing, high, the treating both the principal and secondary aspects of a disease of bioavailability, pure Chinese medicine composition of effective treatment fish white head and mouth fish disease of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of the fish white head and mouth fish disease, by following component by weight mixed preparing form: Flos Lonicerae 15-35 part, Radix Angelicae Dahuricae 15-35 part, Rhizoma Zingiberis 20-40 part, Radix Glycyrrhizae 20-40 part, Rhizoma Atractylodis Macrocephalae 15-35 part, Radix Pulsatillae 25-45 part, Pericarpium Granati 20-40 part, Herba Artemisiae Scopariae 20-40 part, Herba Plantaginis 20-40 part, Radix Sophorae Flavescentis 20-40 part.
Described various component optimum ratio amount is: 25 parts of Flos Loniceraes, 25 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Zingiberiss, 30 parts in Radix Glycyrrhizae, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 35 parts of the Radix Pulsatillaes, 30 parts of Pericarpium Granatis, 30 parts of Herba Artemisiae Scopariaes, 30 parts of Herba Plantaginiss, 30 parts of Radix Sophorae Flavescentiss.
A kind of preparation method for the treatment of the pure Chinese medicine composition of fish white head and mouth fish disease, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Flos Lonicerae 15-35 part, Radix Angelicae Dahuricae 15-35 part, Rhizoma Zingiberis 20-40 part, Radix Glycyrrhizae 20-40 part, Rhizoma Atractylodis Macrocephalae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Pulsatillae 25-45 part, Pericarpium Granati 20-40 part, Herba Artemisiae Scopariae 20-40 part, Herba Plantaginis 20-40 part, Radix Sophorae Flavescentis 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
The Radix Angelicae Dahuricae: hot, warm, return large intestine, lung, stomach warp, have the function of mending loose wind damp eliminating, detumescence and apocenosis, understand things pain-stopping; Cure mainly affection of exogenous wind-cold, rheumatic arthralgia, the yellow furunculosis of skin ulcer, rhinocleisis etc.
Rhizoma Zingiberis: hot, hot, return spleen, stomach, kidney, suffering, lung meridian, have warming middle-JIAO by cold, recuperating depleted YANG is promoted blood circulation, the function of dampness expectorant; Cure mainly that cold syndrome of the stomach lack of appetite, cold intestinal are had loose bowels, cold type of pain, extreme cold of the limbs, anemofrigid-damp arthralgia, phlegm retention breath with cough etc.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, return spleen, stomach warp, have the function of invigorating the spleen and replenishing QI, dampness diuretic; Cure mainly diarrhea due to hypofunction of the spleen, edema etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
Herba Artemisiae Scopariae: bitter, hot, be slightly cold, return spleen, stomach, liver, gallbladder meridian, have the function of eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Cure mainly jaundice, oliguria, eczema pruritus etc.
Pericarpium Granati: sour, puckery, warm, return large intestine channel, have the function of relieving diarrhea with astringents, hemostasis, anthelmintic; Cure mainly dysentery, have blood in stool, proctoptosis, malnutrition due to parasitic infestation etc.
Herba Plantaginis: sweet, cold, return lung, kidney, liver, small intestine meridian, have clearing away heat and promoting diuresis, eliminate the phlegm, the function of removing heat from blood, detoxifcation; Cure mainly that pyretic stranguria, short urination are red, diarrhea due to damp-heat, phlegm-heat cough, carbuncle sore tumefacting virus etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, the heart, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
More than all herbal medicines according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of fish white head and mouth fish disease, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, and it is wide to draw materials, micronizing, bioavailability height, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment fish white head and mouth fish disease is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of the fish white head and mouth fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 150 parts of Flos Loniceraes, 150 parts of the Radixs Angelicae Dahuricae, 200 parts of Rhizoma Zingiberiss, 200 parts in Radix Glycyrrhizae, 150 parts of the Rhizoma Atractylodis Macrocephalaes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of the Radix Pulsatillaes, 200 parts of Pericarpium Granatis, 200 parts of Herba Artemisiae Scopariaes, 200 parts of Herba Plantaginiss, 200 parts of Radix Sophorae Flavescentiss, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of the fish white head and mouth fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Flos Loniceraes, 250 parts of the Radixs Angelicae Dahuricae, 300 parts of Rhizoma Zingiberiss, 300 parts in Radix Glycyrrhizae, 250 parts of the Rhizoma Atractylodis Macrocephalaes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of the Radix Pulsatillaes, 300 parts of Pericarpium Granatis, 300 parts of Herba Artemisiae Scopariaes, 300 parts of Herba Plantaginiss, 300 parts of Radix Sophorae Flavescentiss, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of the fish white head and mouth fish disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Flos Loniceraes, 350 parts of the Radixs Angelicae Dahuricae, 400 parts of Rhizoma Zingiberiss, 400 parts in Radix Glycyrrhizae, 350 parts of the Rhizoma Atractylodis Macrocephalaes, mix 5-10 minute to even;
(3) take by weighing by weight 450 parts of the Radix Pulsatillaes, 400 parts of Pericarpium Granatis, 400 parts of Herba Artemisiae Scopariaes, 400 parts of Herba Plantaginiss, 400 parts of Radix Sophorae Flavescentiss, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
The clinical experiment animal selects 180 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus white head and mouth fish disease.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 60 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " strong fish is precious loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 2% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment Ctenopharyngodon idellus white head and mouth fish disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 33.3 | 26.7 | 40.0 |
| II | The precious loose group of strong fish | 10.0 | 76.7 | 13.3 |
| III | Present composition group | 6.7 | 86.6 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the precious loose group of strong fish aspect the cure rate.
Safety testing:
Choose 80 age in days healthy grass carp, 30 tails, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment fish white head and mouth fish disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of the fish white head and mouth fish disease, it is characterized in that by following component by weight mixed preparing form: Flos Lonicerae 15-35 part, Radix Angelicae Dahuricae 15-35 part, Rhizoma Zingiberis 20-40 part, Radix Glycyrrhizae 20-40 part, Rhizoma Atractylodis Macrocephalae 15-35 part, Radix Pulsatillae 25-45 part, Pericarpium Granati 20-40 part, Herba Artemisiae Scopariae 20-40 part, Herba Plantaginis 20-40 part, Radix Sophorae Flavescentis 20-40 part.
2. the pure Chinese medicine composition for the treatment of according to claim 1 fish white head and mouth fish disease, it is characterized in that by following component by weight mixed preparing form: 25 parts of Flos Loniceraes, 25 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Zingiberiss, 30 parts in Radix Glycyrrhizae, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 35 parts of the Radix Pulsatillaes, 30 parts of Pericarpium Granatis, 30 parts of Herba Artemisiae Scopariaes, 30 parts of Herba Plantaginiss, 30 parts of Radix Sophorae Flavescentiss.
3. the preparation method of the pure Chinese medicine composition of a treatment according to claim 1 and 2 fish white head and mouth fish disease is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Flos Lonicerae 15-35 part, Radix Angelicae Dahuricae 15-35 part, Rhizoma Zingiberis 20-40 part, Radix Glycyrrhizae 20-40 part, Rhizoma Atractylodis Macrocephalae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Pulsatillae 25-45 part, Pericarpium Granati 20-40 part, Herba Artemisiae Scopariae 20-40 part, Herba Plantaginis 20-40 part, Radix Sophorae Flavescentis 20-40 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933184A (en) * | 2014-04-22 | 2014-07-23 | 湖州天健兽药有限公司 | Traditional Chinese medicine composition for treating white head-mouth disease of fishes |
| CN104398556A (en) * | 2014-12-08 | 2015-03-11 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine compound for preventing and controlling white head-mouth disease of grass carp fries and preparation method |
| CN104435423A (en) * | 2014-11-13 | 2015-03-25 | 桂东县华溪石蛙养殖专业合作社 | Traditional Chinese medicine composition for preventing and treating skin disease of rana spinosa and preparation method of traditional Chinese medicine composition |
| CN105106894A (en) * | 2015-09-15 | 2015-12-02 | 青岛海之源智能技术有限公司 | Chinese herbal medicine preparation for treating white head-mouth disease of xiphophorus helleri and preparation method thereof |
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| CN103933184A (en) * | 2014-04-22 | 2014-07-23 | 湖州天健兽药有限公司 | Traditional Chinese medicine composition for treating white head-mouth disease of fishes |
| CN103933184B (en) * | 2014-04-22 | 2016-08-31 | 湖州天健兽药有限公司 | A kind of Chinese medicine composition treating Fish white head and mouth fish disease |
| CN104435423A (en) * | 2014-11-13 | 2015-03-25 | 桂东县华溪石蛙养殖专业合作社 | Traditional Chinese medicine composition for preventing and treating skin disease of rana spinosa and preparation method of traditional Chinese medicine composition |
| CN104435423B (en) * | 2014-11-13 | 2017-12-29 | 桂东县华溪石蛙养殖专业合作社 | Prevent and treat dermopathic Chinese medicine composition of the stone frog and preparation method thereof |
| CN104398556A (en) * | 2014-12-08 | 2015-03-11 | 鼎正动物药业（天津）有限公司 | Traditional Chinese medicine compound for preventing and controlling white head-mouth disease of grass carp fries and preparation method |
| CN105106894A (en) * | 2015-09-15 | 2015-12-02 | 青岛海之源智能技术有限公司 | Chinese herbal medicine preparation for treating white head-mouth disease of xiphophorus helleri and preparation method thereof |
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