CN103599220B - Compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof - Google Patents
Compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof Download PDFInfo
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- CN103599220B CN103599220B CN201310581634.6A CN201310581634A CN103599220B CN 103599220 B CN103599220 B CN 103599220B CN 201310581634 A CN201310581634 A CN 201310581634A CN 103599220 B CN103599220 B CN 103599220B
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Abstract
The present invention relates to a kind of compound bee-glue composition for the treatment of house pet mange and scab, by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and said composition has no side effect, pollution-free, drug residue free, have no drug resistance, and micronizing, bioavailability are high, curative effect highly significant, and clinical proof has specially good effect to treatment house pet mange and scab.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof, belong to field of animal, be particularly a kind ofly specifically designed to compound bee-glue composition for the treatment of house pet mange and scab and preparation method thereof.
Background technology
House pet mange and scab is a kind of high degree in contact infectious dermatosis caused by acaricide, loses hair or feathers for feature with itch all over and affected part.House pet infects this disease, often occurs that symptom, the bodies such as play is itched, depilation are become thin gradually, affect growth promoter, more do not caused death for a long time, causes very large economic loss to house pet industry.
The traditional Chinese medical science thinks that this disease belongs to exopathogen invading into the interior, damp and hot skin of fighting mutually, and caused by QI and blood is weak, treatment should adopt heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, except wind is antipruritic, the principle of cool blood and remove dampness, strengthening vital QI to eliminate pathogenic factors.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm house pet industry.
This disease is all livestock culturing countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And western medical treatment is mainly based on sterilization, antiinflammatory etc., Western medicine is because its toxic and side effects is strong, easily produce the problem such as drug resistance and drug residue, and clinical practice is very limited.
Therefore research and develop and a kind ofly treat the having no side effect of house pet mange and scab, drug residue free, the specific medicament that produces of having no drug resistance are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and compound bee-glue composition and preparation method thereof of effective treatment house pet mange and scab of drug residue.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of house pet mange and scab, by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part.
Described various component optimum ratio amount is: propolis 25 parts, Radix Angelicae Pubescentis 25 parts, Rhizoma Ligustici 25 parts, Radix Trichosanthis 30 parts, Semen Ziziphi Spinosae 30 parts, Ramulus Uncariae Cum Uncis 25 parts, Radix Dipsaci 25 parts, Fructus Crataegi 25 parts, Radix Sanguisorbae 25 parts, Crinis Carbonisatus 25 parts, Fructus Quisqualis 35 parts, Fructus Carpesii 25 parts.
Treat a preparation method for the compound bee-glue composition of house pet mange and scab, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part by weight, mix 5-10 minute to even;
(3) take Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, lung, stomach warp, has anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improves that immunity, antiallergic are oxidized, stop blooding, moisturize, the function etc. of relieving cough and asthma, protection gastrointestinal mucosa.
Radix Angelicae Pubescentis: bitter, be slightly cold, returns lung, kidney, spleen channel, has the function of nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, QI invigorating, clearing away heat and cooling blood; Cure mainly lung-heat cough with asthma, consumption of YIN caused by febrile disease, carbuncle sore tumefacting virus, scabies etc.
Rhizoma Ligustici: pungent, warm, returns urinary bladder channel, have dispel the wind, cold expelling, dehumidifying, pain relieving function; Cure mainly anemofrigid-damp arthralgia, waist hip swell and ache, tetanus etc.
Radix Trichosanthis: sweet, bitter, cold, attaches to the lung and stomach meridians, has the function of clearing away heat and promoting production of body fluid, detumescence and apocenosis, relieving cough and resolving phlegm; Cure mainly calentura excessive thirst, lung-heat type cough, interior-heat quenched one's thirst, sore swollen toxin etc.
Semen Ziziphi Spinosae: sweet, sour, flat, returns liver, the heart, spleen, gallbladder meridian, and having feels relieved calms the nerves, the function of tonifying liver gallbladder, arresting sweating; Cure mainly terrified, the spontaneous sweating of having a guilty conscience etc.
Ramulus Uncariae Cum Uncis: sweet, cold, returns liver, heart channel, has the function that is relieving convulsion, heat clearing away suppressing the hyperactive liver that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.; Cure mainly that infantile convulsion, conjunctival congestion and swelling pain, mouth mouth are crooked, tetanus etc.
Radix Dipsaci: warm, pungent, bitter, returns liver, kidney channel, has the function in invigorating the liver and kidney, reuniting the fractured tendons and bones, promoting blood circulation, sharp joint; Cure mainly muscles and bones fractureing, traumatic injury, rheumatic arthralgia, frequent fetal movement, carbuncle and ulcer treatment poison etc.
Fructus Crataegi: warm, sweet, sour, returns liver, stomach, spleen channel, has the function that removing food stagnancy, clots absorbing, change are stagnant; Cure mainly that dyspepsia, insufficiency of the spleen stomach are weak, constipation or stagnantly to have loose bowels.
Radix Sanguisorbae: bitter, sour, cold, returns stomach, liver, kidney, lung meridian, has cooling blood for hemostasis, heat-clearing and toxic substances removing, the function of detumescence sore; Cure mainly dysentery, have blood in stool, hematuria, burnt degree heating etc.
Crinis Carbonisatus: bitter, tepor, returns stomach, liver, kidney channel, has the function of hemostasis, blood stasis dispelling, diuresis, granulation promoting; Cure mainly various hemorrhage etc.
Fructus Quisqualis: sweet, warm, returns large intestine, stomach, spleen channel, has the function of anthelmintic, spleen invigorating removing food stagnancy; Cure mainly ascarid, scabies etc.
Fructus Carpesii: bitter, flat, returns liver, stomach, spleen channel, has the function of parasite killing, heat-clearing and toxic substances removing, invigorating the spleen and regulating the stomach; Cure mainly gastrointestinal parasite, external mange and scab etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for paathogenic factor and the clinical symptoms of house pet mange and scab, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, and optimize this 12 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, has specially good effect to treatment house pet mange and scab.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind ofly treat compound bee-glue composition of house pet mange and scab and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 150 parts, Radix Angelicae Pubescentis 150 parts, Rhizoma Ligustici 150 parts, Radix Trichosanthis 150 parts, Semen Ziziphi Spinosae 150 parts, Ramulus Uncariae Cum Uncis 150 parts by weight, mix 5-10 minute to even;
(3) take Radix Dipsaci 150 parts, Fructus Crataegi 150 parts, Radix Sanguisorbae 150 parts, Crinis Carbonisatus 150 parts, Fructus Quisqualis 150 parts, Fructus Carpesii 150 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind ofly treat compound bee-glue composition of house pet mange and scab and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 250 parts, Radix Angelicae Pubescentis 250 parts, Rhizoma Ligustici 250 parts, Radix Trichosanthis 300 parts, Semen Ziziphi Spinosae 300 parts, Ramulus Uncariae Cum Uncis 250 parts by weight, mix 5-10 minute to even;
(3) take Radix Dipsaci 250 parts, Fructus Crataegi 250 parts, Radix Sanguisorbae 250 parts, Crinis Carbonisatus 250 parts, Fructus Quisqualis 350 parts, Fructus Carpesii 250 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind ofly treat compound bee-glue composition of house pet mange and scab and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 350 parts, Radix Angelicae Pubescentis 350 parts, Rhizoma Ligustici 350 parts, Radix Trichosanthis 400 parts, Semen Ziziphi Spinosae 450 parts, Ramulus Uncariae Cum Uncis 350 parts by weight, mix 5-10 minute to even;
(3) take Radix Dipsaci 350 parts, Fructus Crataegi 350 parts, Radix Sanguisorbae 350 parts, Crinis Carbonisatus 350 parts, Fructus Quisqualis 550 parts, Fructus Carpesii 350 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 100-180 age in days, Laboratory Diagnosed to be ill capital bar dog of mange and scab.Ill dog isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and drug control group institute's control drug " " Jiexuanling " medicine for treating scabies falls apart " by specification uses treatment; Product of the present invention (compositions obtained by the embodiment of the present invention 2) can brew with boiled water by Chinese medicine composition group of the present invention, waits temperature and gavages, once a day, each 100 grams-250 grams, be used in conjunction 5-7 days.Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result at the end of experiment.
Efficacy assessment standard:
Cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, and body temperature is normal, skin is normal.The positions such as test in laboratory skin do not find the pathogenic microorganisms such as acaricide.
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
Table is that the Field information situation that the present invention and other medicines treat dog mange and scab contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 10 | 13.3 | 76.7 |
| II | " Jiexuanling " medicine for treating scabies falls apart group | 6.7 | 76.7 | 16.6 |
| III | Present composition group | 3.3 | 86.7 | 10 |
This clinical effectiveness statistical analysis, present composition group and " Jiexuanling " medicine for treating scabies fall apart group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 2 monthly age healthy dogs 10,5 times of time temperature according to the made compositions recommended dose of the embodiment of the present invention 2 gavage 10 days, during medication, and observation experiment dog is without any bad or Deviant Behavior performance, and drinking-water of searching for food is normal.
Above-mentioned detailed description of compound bee-glue composition of this treatment house pet mange and scab and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for house pet mange and scab, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part, Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part.
2. the compound bee-glue composition for the treatment of house pet mange and scab according to claim 1, is characterized in that described various component optimum ratio amount is: propolis 25 parts, Radix Angelicae Pubescentis 25 parts, Rhizoma Ligustici 25 parts, Radix Trichosanthis 30 parts, Semen Ziziphi Spinosae 30 parts, Ramulus Uncariae Cum Uncis 25 parts, Radix Dipsaci 25 parts, Fructus Crataegi 25 parts, Radix Sanguisorbae 25 parts, Crinis Carbonisatus 25 parts, Fructus Quisqualis 35 parts, Fructus Carpesii 25 parts.
3. a preparation method for the compound bee-glue composition for the treatment of house pet mange and scab according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Radix Angelicae Pubescentis 15-35 part, Rhizoma Ligustici 15-35 part, Radix Trichosanthis 15-40 part, Semen Ziziphi Spinosae 15-45 part, Ramulus Uncariae Cum Uncis 15-35 part by weight, mix 5-10 minute to even;
(3) take Radix Dipsaci 15-35 part, Fructus Crataegi 15-35 part, Radix Sanguisorbae 15-35 part, Crinis Carbonisatus 15-35 part, Fructus Quisqualis 15-55 part, Fructus Carpesii 15-35 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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| CN103877326A (en) * | 2014-03-15 | 2014-06-25 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating acariasis of domestic animals and preparation method thereof |
| WO2017010858A1 (en) * | 2015-07-15 | 2017-01-19 | Flores Samaniego Beatriz | Composition based on extracts of heliopsis longipes and propolis for the control and/or elimination of ticks |
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| CN101204529A (en) * | 2007-12-18 | 2008-06-25 | 秦庆吉 | Medicine for wound-curing and scar-dispeling |
| CN101278943B (en) * | 2008-05-19 | 2010-12-08 | 郝天好 | Externally-applied medicine for curing psora |
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Granted publication date: 20150729 Termination date: 20161112 |