CN103893696A - Traditional Chinese medicinal composition for treating hepatic fascioliasis of cattle and sheep and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating hepatic fascioliasis of cattle and sheep and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating hepatic fascioliasis of cattle and sheep. The composition is prepared by mixing the following components in parts by weight: 15-35 parts of dried tangerine peel, 15-45 parts of eucommia ulmoides, 15-35 parts of codonopsis pilosula, 15-35 parts of astragalus membranaceus, 15-35 parts of szechwan chinaberry fruit, 15-45 parts of rhizoma dryopteris crassirhizomae, 15-35 parts of wrinkled giant hyssop, 15-35 parts of rhizoma sparganii, 15-45 parts of liquorice, 15-35 parts of cape jasmine fruit, 15-45 parts of areca-nut, 15-25 parts of uncaria, 15-35 parts of immature bitter orange and 15-25 parts of curcuma zedoary. The traditional Chinese medicinal composition has the beneficial effects of reasonable formula, simple preparation, no pollution, no toxic or side effect, no drug-resistance, no drug residue and remarkable curative effect, and has a unique effect on hepatic fascioliasis of cattle and sheep by means of clinical verification.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment cattle and sheep fascioliasis hepatica and preparation method thereof.
Background technology
Cattle and sheep fascioliasis hepatica is to parasitize caused a kind of comparatively serious parasitic disease in the liver bile ducts of cattle and sheep by the distoma hepaticum of Fasciolidae Fasciola.Primary disease can cause that cattle and sheep are acute, chronic hepatitis and cholangitis, and the systemic toxicity that simultaneously occurs together and malnutrition, decline cattle and sheep fertility performance, and young stock can cause large quantities of death, produces and brings huge economic loss to animal husbandry.
At present, this disease can only be treated with anthelmintics such as nitre chlorine powder, the two dichloro powder of sulfur, Albendazole, carbon tetrachloride, once produce drug resistance, this disease is difficult to cure; And also having drug residue, its livestock products affect health.This disease is to pig industry and people are healthy causes very large threat.
Therefore research and develop a kind of treat cattle and sheep fascioliasis hepatica and have no side effect, drug residue free, have no drug resistance produce specific medicament be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, have no side effect, have no drug resistance generation, drug residue free, successful, effectively treat Chinese medicine composition of cattle and sheep fascioliasis hepatica and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of cattle and sheep fascioliasis hepatica, by following component by weight mixed preparing form: Pericarpium Citri Reticulatae 15-35 part, Cortex Eucommiae 15-45 part, Radix Codonopsis 15-35 part, Radix Astragali 15-35 part, Fructus Toosendan 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Pogostemonis 15-35 part, Rhizoma Sparganii 15-35 part, Radix Glycyrrhizae 15-45 part, Fructus Gardeniae 15-35 part, Semen Arecae 15-45 part, an ancient unit of weight rattan 15-25 part, Fructus Aurantii Immaturus 15-35 part, Rhizoma Curcumae 15-25 part.
Described various component optimum ratio amount is: 25 parts of Pericarpium Citri Reticulataes, 30 parts of the Cortexs Eucommiae, 25 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 25 parts of Fructus Toosendans, 30 parts of Rhizoma Dryopteris Crassirhizomatiss, 25 parts of Herba Pogostemoniss, 25 parts of Rhizoma Sparganii, 30 parts, Radix Glycyrrhizae, 25 parts of Fructus Gardeniaes, 30 parts of Semen Arecaes, 20 parts of Ramulus Uncariae Cum Uncis, 25 parts of Fructus Aurantii Immaturuss, 20 parts of Rhizoma Curcumae.
Treat a preparation method for the Chinese medicine composition of cattle and sheep fascioliasis hepatica, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Pericarpium Citri Reticulatae 15-35 part, Cortex Eucommiae 15-45 part, Radix Codonopsis 15-35 part, Radix Astragali 15-35 part, Fructus Toosendan 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Pogostemonis 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Sparganii 15-35 part, Radix Glycyrrhizae 15-45 part, Fructus Gardeniae 15-35 part, Semen Arecae 15-45 part, Ramulus Uncariae Cum Uncis 15-25 part, Fructus Aurantii Immaturus 15-35 part, Rhizoma Curcumae 15-25 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
The Cortex Eucommiae: sweet, warm, return liver, kidney channel, there is invigorating the liver and kidney, bone and muscle strengthening, antiabortive function; Cure mainly that lumbago due to renal deficiency, waist are unable, rheumatic arthralgia, frequent fetal movement etc.
Semen Arecae: bitter, pungent, warm, return stomach, large intestine channel, there is the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, constipation, edema etc.
Radix Codonopsis: sweet, flat, return spleen, lung meridian, there is the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down de-etc.
The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.
Rhizoma Dryopteris Crassirhizomatis: bitter, cold, return liver, stomach warp, there is the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.
Fructus Toosendan: bitter, cold, return Liver Channel, there is the function of catharsis liver-heat, promoting the circulation of QI to relieve pain; Cure mainly except damp and hot, clearing away liver-fire, pain relieving, parasite killing etc.
Herba Pogostemonis: sweet, light, cold, return kidney, urinary bladder channel, there is the function of diuresis, clearing away damp-heat; Cure mainly dysuria, edema distension, diarrhea due to damp-heat etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Rhizoma Sparganii: pungent, cool, return liver, spleen channel, have that blood stasis dispelling stimulates the menstrual flow, a function of removing blood stasis eliminating mass, circulation of qi promoting removing food stagnancy; Cure mainly enclosed mass, abdominal pain due to retention of food etc. in amenorrhea due to stagnation of blood, postpartum stagnation stomachache, traumatic injury congestive edema, abdomen.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Ramulus Uncariae Cum Uncis: sweet, cool, return liver, pericardium channel, the function that there is heat clearing away suppressing the hyperactive liver, relieves dizziness, high fever, infantile convulsions, epilepsy, etc. and calm the frightened; Cure mainly wind-heat of liver channel, spasm tic, young stock convulsion etc.
Fructus Aurantii Immaturus: bitter, pungent, sour, warm, return spleen, stomach warp, there is dispelling the stagnated QI removing food stagnancy, reduce phlegm, the function of de-swelling; Cure mainly that food stagnation does not disappear, tripe is swollen, feces is constipated, hang down de-disease, the stagnant vapour lock of expectorant etc.
Rhizoma Curcumae: acrid, bitter, warm, return liver, spleen channel, there is the function of broken silt removing food stagnancy, promoting the circulation of QI to relieve pain; Cure mainly stagnation of QI-blood, tripe abdominal distention and pain, accumulation of food in the stomach and intes tine due to indigestion, traumatic injury etc.
All taste Chinese medicine, according to tcm theory compatible combination, for the pathological change of cattle and sheep fascioliasis hepatica, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.According to the tradition Chinese veterinarian of motherland, theoretical and modern Chinese medicine pharmacology theory, optimizes this 14 kinds of medicines, and makes them form pure Chinese powder medicine according to optimum ratio, and clinical practice proves that treatment cattle and sheep fascioliasis hepatica is had specially good effect and had no side effect and drug resistance.And make livestock products reach nuisanceless requirement, meet the export standard of livestock products, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of Chinese medicine composition for the treatment of cattle and sheep distoma hepaticum and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Pericarpium Citri Reticulataes, 150 parts of the Cortexs Eucommiae, 150 parts of Radix Codonopsis, 150 parts of the Radixs Astragali, 150 parts of Fructus Toosendans, 150 parts of Rhizoma Dryopteris Crassirhizomatiss, 150 parts of Herba Pogostemoniss, mix 5-10 minute to even;
(3) take by weight 150 parts of Rhizoma Sparganii, 150 parts, Radix Glycyrrhizae, 150 parts of Fructus Gardeniaes, 150 parts of Semen Arecaes, 150 parts of Ramulus Uncariae Cum Uncis, 150 parts of Fructus Aurantii Immaturuss, 150 parts of Rhizoma Curcumae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of Chinese medicine composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Pericarpium Citri Reticulataes, 300 parts of the Cortexs Eucommiae, 250 parts of Radix Codonopsis, 250 parts of the Radixs Astragali, 250 parts of Fructus Toosendans, 300 parts of Rhizoma Dryopteris Crassirhizomatiss, 250 parts of Herba Pogostemoniss, mix 5-10 minute to even;
(3) take by weight 250 parts of Rhizoma Sparganii, 300 parts, Radix Glycyrrhizae, 250 parts of Fructus Gardeniaes, 300 parts of Semen Arecaes, 200 parts of Ramulus Uncariae Cum Uncis, 250 parts of Fructus Aurantii Immaturuss, 200 parts of Rhizoma Curcumae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of Chinese medicine composition for the treatment of cattle and sheep fascioliasis hepatica and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Pericarpium Citri Reticulataes, 450 parts of the Cortexs Eucommiae, 350 parts of Radix Codonopsis, 350 parts of the Radixs Astragali, 350 parts of Fructus Toosendans, 450 parts of Rhizoma Dryopteris Crassirhizomatiss, 350 parts of Herba Pogostemoniss, mix 5-10 minute to even;
(3) take by weight 350 parts of Rhizoma Sparganii, 450 parts, Radix Glycyrrhizae, 350 parts of Fructus Gardeniaes, 450 parts of Semen Arecaes, 250 parts of Ramulus Uncariae Cum Uncis, 350 parts of Fructus Aurantii Immaturuss, 250 parts of Rhizoma Curcumae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 80-150 age in days, body weight at 20kg-40kg, and Laboratory Diagnosed is the ill sheep of Hepar Caprae seu ovis fascioliasis.Ill sheep isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, 20 every group, 3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and medicine matched group uses treatment with " liver fluke is loose " by specification; Chinese medicine composition group of the present invention can gavage ill cattle and sheep by product of the present invention (the prepared compositions of the embodiment of the present invention 2), and a day dose is the 50-100 gram of present composition, every day 1 time, is used in conjunction 3-5 days; After oral, reach the object for the treatment of disease by gastrointestinal absorption.
Efficacy assessment standard:
Cure: spirit is normal, the drinking-water of searching for food is normal, and feces normally waits Hepar Caprae seu ovis fascioliasis clinical symptom disappearance, from the feces of sick sheep, detects and is showed no distoma hepaticum etc. through laboratory.
When end, there is symptom: clinical symptoms is not improved even and increased the weight of.
Table is the field applicable cases contrast of the present invention and other medicines treatment Hepar Caprae seu ovis fascioliasis:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 10 | 0 | 90 |
| II | The liver fluke group of faling apart | 5 | 80 | 15 |
| III | Chinese medicine composition group of the present invention | 0 | 90 | 10 |
This clinical effectiveness statistical analysis, the loose group of present composition group and liver fluke extremely significantly (P<0.01) of difference compared with aspect cure rate.
Safety testing:
Choose 30 of 30 age in days Healthy Sheep, 5 times according to the made Chinese medicine composition recommended dose of the embodiment of the present invention 2 gavage 5 days, during medication, Healthy Sheep is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
The above-mentioned detailed description that Chinese medicine composition to this treatment cattle and sheep fascioliasis hepatica and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for cattle and sheep fascioliasis hepatica, it is characterized in that by following component by weight mixed preparing form: Pericarpium Citri Reticulatae 15-35 part, Cortex Eucommiae 15-45 part, Radix Codonopsis 15-35 part, Radix Astragali 15-35 part, Fructus Toosendan 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Pogostemonis 15-35 part, Rhizoma Sparganii 15-35 part, Radix Glycyrrhizae 15-45 part, Fructus Gardeniae 15-35 part, Semen Arecae 15-45 part, Ramulus Uncariae Cum Uncis 15-25 part, Fructus Aurantii Immaturus 15-35 part, Rhizoma Curcumae 15-25 part.
2. the Chinese medicine composition for the treatment of cattle and sheep fascioliasis hepatica according to claim 1, is characterized in that described various component optimum ratio amount is: 25 parts of Pericarpium Citri Reticulataes, 30 parts of the Cortexs Eucommiae, 25 parts of Radix Codonopsis, 25 parts of the Radixs Astragali, 25 parts of Fructus Toosendans, 30 parts of Rhizoma Dryopteris Crassirhizomatiss, 25 parts of Herba Pogostemoniss, 25 parts of Rhizoma Sparganii, 30 parts, Radix Glycyrrhizae, 25 parts of Fructus Gardeniaes, 30 parts of Semen Arecaes, 20 parts of Ramulus Uncariae Cum Uncis, 25 parts of Fructus Aurantii Immaturuss, 20 parts of Rhizoma Curcumae.
3. a preparation method for the Chinese medicine composition for the treatment of cattle and sheep fascioliasis hepatica according to claim 1 and 2, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Pericarpium Citri Reticulatae 15-35 part, Cortex Eucommiae 15-45 part, Radix Codonopsis 15-35 part, Radix Astragali 15-35 part, Fructus Toosendan 15-35 part, Rhizoma Dryopteris Crassirhizomatis 15-45 part, Herba Pogostemonis 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Sparganii 15-35 part, Radix Glycyrrhizae 15-45 part, Fructus Gardeniae 15-35 part, Semen Arecae 15-45 part, Ramulus Uncariae Cum Uncis 15-25 part, Fructus Aurantii Immaturus 15-35 part, Rhizoma Curcumae 15-25 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| CN201410112272.0A CN103893696A (en) | 2014-03-15 | 2014-03-15 | Traditional Chinese medicinal composition for treating hepatic fascioliasis of cattle and sheep and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749171A (en) * | 2016-04-19 | 2016-07-13 | 烟台民望机电技术有限公司 | Traditional Chinese medicine composition for preventing and treating sheep hepatic fascioliasis |
| CN106075289A (en) * | 2016-07-03 | 2016-11-09 | 张俊清 | A kind of mongolian medicine compositions treating sheep distoma hepaticum |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657808A (en) * | 2012-05-11 | 2012-09-12 | 青岛绿曼生物工程有限公司 | Compound propolis combination for treating cattle and sheep hepatic fascioliasis and preparation method thereof |
-
2014
- 2014-03-15 CN CN201410112272.0A patent/CN103893696A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657808A (en) * | 2012-05-11 | 2012-09-12 | 青岛绿曼生物工程有限公司 | Compound propolis combination for treating cattle and sheep hepatic fascioliasis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 周登柱: "中药"肝蛭散"治疗牛肝片吸虫病", 《贵州畜牧兽医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749171A (en) * | 2016-04-19 | 2016-07-13 | 烟台民望机电技术有限公司 | Traditional Chinese medicine composition for preventing and treating sheep hepatic fascioliasis |
| CN106075289A (en) * | 2016-07-03 | 2016-11-09 | 张俊清 | A kind of mongolian medicine compositions treating sheep distoma hepaticum |
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