CN105749171A - Traditional Chinese medicine composition for preventing and treating sheep hepatic fascioliasis - Google Patents
Traditional Chinese medicine composition for preventing and treating sheep hepatic fascioliasis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating sheep hepatic fascioliasis.The traditional Chinese medicine composition comprises Rhynchosia volubilis Lour, rubus parvifolius, daghestan sweetclover herb, sagina japonica, alchornea davidii, rhododendron, luisia morsei, quisqualis indica leaf, spilanthes paniculata, solanum incanum, glechoma longituba, entada phaseoloides, caragana microphylla, rhodiola dumulosa, sambucus chinensis, poncirus trifoliata, ciliate leucas root, prunus mume and radix curcumae.The traditional Chinese medicine composition for preventing and treating the sheep hepatic fascioliasis has the advantages that the traditional Chinese medicine composition is short in treatment course, quick in action, capable of effectively preventing the sheep hepatic fascioliasis, low in cost, purely natural and free of pollution.
Description
Technical field
The present invention relates to veterinary drug technical field, particularly to a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis and preparation method thereof.
Background technology
Hepar Caprae seu ovis fascioliasis is that distoma hepaticum parasitizes in sheep liver, bile duct, causes chronic or acute hepatitis, cholangitis, the parasitic disease of simultaneously the occur together diseases such as systemic toxicity profiles phenomenon and malnutrition, and harm is quite serious, can cause large quantities of death of young stock and sheep.This disease mostly occurs in season in autumn in summer two, and 6～JIUYUE is season occurred frequently.Sheep has eaten the pasture and water being attached with bladder worm and has infected, the various ages, sex, kind sheep all can infect, the case fatality rate of lamb and sheep is high.Often in endemic conditions, the flock of sheep morbidity herded in low-lying and marshland is more serious.
The worm's ovum of distoma hepaticum excretes with feces, hatches miracidium in water, meets lamnaeid (also crying Limnaea) and just creeps into breechblock, through several stages of development, eventually forms cercaria, leave breechblock and enter in people's water.Cercaria is attached on water plant or other objects, sloughs afterbody and forms bladder worm, and sheep gulps down people bladder worm when pasturing or drink water and infects.After bladder worm arrives enteric cavity, larva is just deviate from from capsule, bores people's intestinal wall, enters people abdominal cavity, arrives liver, creeps into bile duct, grows for adult in bile duct.Primary disease is except sheep, and cattle, camel, pig, deer, rabbit, horse, dog, cat etc. can infect.People also can infect
Clinical symptoms
Spirit is depressed, is off one's feed, and visual mucosa is extremely pale, jaundice, anemia.Sick sheep becomes thin gradually, and by hair slightly disorderly, hair shaft is easily broken, and rib highlights, under eyelid, jaw, the edema of chest and abdomen bottom.What have when herding eats soil, and constipation alternately occurs with diarrhoea, pulls out pitchy loose stool, some band blood.Be in a bad way, generally after 1～2 month, due to illness worsen and dead, the state of an illness is lighter, delay to next year weather get warm again after a cold spell, feedstuff improvement after recover gradually.
Stool examination
Taking fresh excreta 5～10 grams, detect distoma hepaticum ovum with nylon mesh elutriation method or repeated precipitation process, worm's ovum is long oval, golden yellow, is sized to 116～132 microns × 66～82 microns.
The diagnosis of fascioliasis hepatica can according to clinical symptoms, epidemiology, cut open inspection and several respects comprehensive descision such as stool examination.
Prophylactico-therapeutic measures
(1) deworm.The propagation of fascioliasis hepatica stems primarily from disease sheep and carrier, and therefore the sick sheep for the treatment of is not only in anthelmintic, is also positive preventive measure.It is critical only that the time of anthelmintic and number of times.Acute case is typically in the anthelmintic of larval phase late September, and chronic cases is typically in the anthelmintic of adult stage in October.All sheep are only annual in the due twice regular anthelmintic of 2～March and 10～November, and anthelmintic in 10～November is that protection sheep only passes the winter, and prevents sheep morbidity in winter, and anthelmintic in 2～March is to reduce sheep to disseminate source of disease when Xia Qiu herds.
(2) night soil-treatment.Feces in colony house, it is fertile that every day removes laggard windrow, utilizes manure fermentation heat production to kill worm's ovum.To the feces discharged after anthelmintic, strict control, it is impossible to throw out without care, put together heap fermentation and process, it is prevented that pollute sheep hurdle and grassland and infection morbidity again.
(3) pasture prevention.1. select high and dry area to herd, herd less than marsh, low-lying sough.2. rotation grazing.Rotation grazing is the important method preventing fascioliasis hepatica from propagating.Marks such as grassland netting fence, river, brook, shrub, ditch being divided into several community, each community herds 30～40 days, herding to a district of district one in sequence, samsara again and again is herded, and 3. the infection chance to reduce fascioliasis hepatica is herded and combined with drylot feeding.In the winter time and the early spring, very cold, herbage dries up, and most of sheep become thin, weak, have a low resistance, be the period that distoma hepaticum sufferer sheep death quantity is maximum, therefore in this period, drylot feeding should be transferred to by herding, strengthen feeding and management, build up resistance, reduce mortality rate.
(4) drinking water hygiene.In Infected regions, drink the water of the cleaning such as river of tap water, well water or flowing as far as possible, do not arrive low humidity, marshland takes drinking-water.
(5) intermediate host is eliminated.Eliminate the important measures that intermediate host lamnaeid is prevention fascioliasis hepatica.Herd area, by building water conservancy projects, fill and lead up transformation flat, change the living condition of lamnaeid, the purpose of the spiral shell that reaches to go out.According to document announcement, herding area, jumpbogroup duck culturing, lamnaeid can be eliminated, the development of duck culturing industry can be promoted again, be the good thing killed two birds with one stone.
(6) process of ill internal organs.The liver having polypide disorderly can not be abandoned or cleaned in river, or the water around washing liver is sprinkled, and make cause of disease spread artificially, the liver having serious change be made buried or burning etc. immediately and destroys.
Doctor trained in Western medicine is in treatment fascioliasis hepatica, and alternative medicament categories is limited, and therapeutic scheme limits to, and clinical effectiveness is very unobvious.Further, prolonged application drug residue is higher, and consumer eats this type of Carnis caprae seu ovis and its immunity of organisms can be had a negative impact.Optimal anthelmintic drug is nitroclofene, every kg body weight 3～5 milligrams, gavages for l time on an empty stomach, every day 1 time, is used in conjunction 3 days.It addition, also have the medicines such as hydrazine phenol thiophene, liver fluke clean, trematodiasis obtains only, albendazole, bithionol, may select and take.
But, Chinese medicine not only has the curative effect of Western medicine, and also has the untouchable advantageous feature of doctor trained in Western medicine.Adopting Traditional Chinese medical theory for instructing, based on Overall View, adopt the principle of " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods " according to different clinical symptoms, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, cure rate is high, pollution-free.Treatment by Chinese herbs have instant effect, curative effect really, be not likely to produce Drug resistance, inexpensively, not easily recurrence, few side effects, livestock products drug residue is low, be conducive to the advantages such as person poultry safety.
Summary of the invention
The technical problem to be solved is to be in that to provide a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, adopts this Chinese medicine composition can overcome the defect of prior art Chinese medicine and western medicine and Chinese medicine, treats Hepar Caprae seu ovis fascioliasis, and cure rate is high, pollution-free；Instant effect, determined curative effect, be not likely to produce Drug resistance, inexpensively, not easily recurrence, few side effects, livestock products drug residue is low, be conducive to the advantages such as person poultry safety.
In order to realize foregoing invention purpose, the invention provides a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, described Chinese medicine composition includes following raw medicinal material: Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae, Cortex Alchorneae Davidii, Cuculus polioephalus, Radix Seu Herba Luisiae Morsei, Folium Quisqualis, Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae, vine, Herba Caraganae intermediae, Radix Rhodiolae Dumulosae, Herba Sambuci Chiensis, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), the Leucas ciliata Benth, Flos Mume and Radix Curcumae.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 5-9 weight portion, Rubus Parvifolius L. 22-32 weight portion, Herba Meliloti Suaveolentis 8-15 weight portion, Herba Saginae Japonicae 11-22 weight portion, Cortex Alchorneae Davidii 14-21 weight portion, Cuculus polioephalus 13-28 weight portion, Radix Seu Herba Luisiae Morsei 7-12 weight portion, Folium Quisqualis 17-26 weight portion, Herba Spilanthis Acmellae 13-24 weight portion, yellow fluid eggplant 13-26 weight portion, Herba Glechomae 12-26 weight portion, vine 8-16 weight portion, Herba Caraganae intermediae 10-25 weight portion, Radix Rhodiolae Dumulosae 8-14 weight portion, Herba Sambuci Chiensis 21-34 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20-36 weight portion, Leucas ciliata Benth 19-33 weight portion, Flos Mume 28-39 weight portion and Radix Curcumae 17-31 weight portion.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 9 weight portion, Rubus Parvifolius L. 24 weight portion, Herba Meliloti Suaveolentis 8 weight portion, Herba Saginae Japonicae 11 weight portion, Cortex Alchorneae Davidii 18 weight portion, Cuculus polioephalus 22 weight portion, Radix Seu Herba Luisiae Morsei 12 weight portion, Folium Quisqualis 26 weight portion, Herba Spilanthis Acmellae 13 weight portion, yellow fluid eggplant 15 weight portion, Herba Glechomae 19 weight portion, vine 8 weight portion, Herba Caraganae intermediae 25 weight portion, Radix Rhodiolae Dumulosae 14 weight portion, Herba Sambuci Chiensis 29 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 31 weight portion, the Leucas ciliata Benth 19 weight portion, Flos Mume 39 weight portion and Radix Curcumae 23 weight portion.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 5 weight portion, Rubus Parvifolius L. 32 weight portion, Herba Meliloti Suaveolentis 11 weight portion, Herba Saginae Japonicae 22 weight portion, Cortex Alchorneae Davidii 14 weight portion, Cuculus polioephalus 28 weight portion, Radix Seu Herba Luisiae Morsei 7 weight portion, Folium Quisqualis 17 weight portion, Herba Spilanthis Acmellae 24 weight portion, yellow fluid eggplant 13 weight portion, Herba Glechomae 26 weight portion, vine 13 weight portion, Herba Caraganae intermediae 20 weight portion, Radix Rhodiolae Dumulosae 8 weight portion, Herba Sambuci Chiensis 34 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 weight portion, the Leucas ciliata Benth 28 weight portion, Flos Mume 32 weight portion and Radix Curcumae 17 weight portion.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 6 weight portion, Rubus Parvifolius L. 22 weight portion, Herba Meliloti Suaveolentis 15 weight portion, Herba Saginae Japonicae 17 weight portion, Cortex Alchorneae Davidii 21 weight portion, Cuculus polioephalus 13 weight portion, Radix Seu Herba Luisiae Morsei 9 weight portion, Folium Quisqualis 23 weight portion, Herba Spilanthis Acmellae 21 weight portion, yellow fluid eggplant 26 weight portion, Herba Glechomae 12 weight portion, vine 16 weight portion, Herba Caraganae intermediae 10 weight portion, Radix Rhodiolae Dumulosae 10 weight portion, Herba Sambuci Chiensis 21 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 36 weight portion, the Leucas ciliata Benth 33 weight portion, Flos Mume 28 weight portion and Radix Curcumae 31 weight portion.
In order to better realize goal of the invention, the preparation method that the present invention also provides for a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, when the dosage form of described Chinese medicine composition is tablet, its preparation method comprises the following steps:
The first step, Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae and Cortex Alchorneae Davidii are mixed, add relative to the alcohol reflux that mixture 3 times～5 times amount determining alcohol is 55%～65% 2 times～4 times, each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae and vine, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1～3: 0.15～0.3.
In order to better realize goal of the invention, the preparation method that the present invention also provides for a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, when the dosage form of described pharmaceutical composition is powder, its preparation method comprises the following steps:
The mixing of each crude drug score ratio by weight being broken into coarse powder, further pulverizes, cross 50 mesh sieves, enable and reaching 60% by the fine powder amount of 50 mesh sieves, the fine powder being collected by 50 mesh sieves obtains fine powder a；Will not pass through the coarse powder of 50 mesh sieves again and put into multi-function extractor extraction twice, first time adds 6 times amount soak by water 1.5-2 hour, and second time adds 5 times amount soak by water 1-2.0 hour, merges twice decocting liquid, filters to get filtrate；Heating is concentrated into pasty state, puts into cooling after 95 DEG C of baking oven is dried, grinds to form fine powder b, makes powder after being mixed by fine powder a and b.
The technical scheme that the embodiment of the present invention provides has the benefit that the traditional Chinese medicine composition for treating Hepar Caprae seu ovis fascioliasis cure rate of the present invention is high, pollution-free；Short treating period, instant effect, determined curative effect, be not likely to produce Drug resistance, inexpensively, not easily recurrence, few side effects, livestock products drug residue is low, be conducive to the advantages such as person poultry safety；And can effectively prevent Hepar Caprae seu ovis fascioliasis.
Detailed description of the invention
The present invention provides a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, and Chinese medicine composition includes following raw medicinal material: Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae, Cortex Alchorneae Davidii, Cuculus polioephalus, Radix Seu Herba Luisiae Morsei, Folium Quisqualis, Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae, vine, Herba Caraganae intermediae, Radix Rhodiolae Dumulosae, Herba Sambuci Chiensis, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), the Leucas ciliata Benth, Flos Mume and Radix Curcumae.
The pharmacology of each raw medicinal material is as follows:
Herba rhynchosiae volubilis: another name deer bean (" elegant " Guo Pu note), bean, wild Semen phaseoli radiati (" detailed outline "), wild Semen Glycines (" China main plant figure says pulse family "), mouse eye (" Guangzhou flora "), mouse bean, wild green soyabeans, door are thin, wine pot rattan (" Hunan medicine will "), bird's eye eyeball bean, great Ye open country Semen phaseoli radiati (" light Rhizoma Dioscoreae plants will in Zhejiang ").Stem and leaf for leguminous plant Herba rhynchosiae volubilis.Bitter in the mouth；Acid；Property is put down.Return stomach；Spleen；Liver Channel.Expelling wind and removing dampness；Invigorate blood circulation；Removing toxic substances.Main air pain of dampness syndrome；Headache；Toothache；Lumbar vertebrae pain；Abdominal pain due to blood stasis；Lochiopyra；Scrofula；Carbuncle sore tumefacting virus；Traumatic injury；Burn and scald.
Rubus Parvifolius L.: another name She Pao, Herba Rubi parvifolii, Fructus Mume disappear, Herba Rubi parvifolii, ull up seedling.Rosaceae rubus Rubus Parvifolius L. is used as medicine with root or stem, leaf.Bitter, puckery, cool.Clearing away heat and cooling blood, eliminating stagnation, pain relieving, inducing diuresis to remove edema.For cold, fever, laryngopharynx swelling and pain, spitting of blood, spit blood, dysentery, enteritis, hepatitis, hepatosplenomegaly, oedema due to nephritis, urinary system infection, calculus, menoxenia, leucorrhea, rheumatic ostalgia, treating swelling and pain by traumatic injury；Eczema, dermatitis are controlled in external.
Herba Meliloti Suaveolentis: another name Herba medicaginis falcatae, product river, Fu (" China main plant figure says pulse family "), Kochia scoparia (" Traditional Chinese Medicine in Sichuan will "), Herba boeae clarkeanae (" medicine investigation is planted in Shaanxi "), Ocimum basilicum L. var. pilosum, wild peanut, Caput Gallus domesticus flowers and plants (" Chinese herbal medicine is commonly used in Shanghai "), chicken lousewort (" Chinese herbal medicine is commonly used in Sichuan "), Herba Meliloti officinalis (" Jilin Chinese herbal medicine "), smelly Herba Medicaginis, the grass that relieves internal heat (" Shaanxi Chinese herbal medicine "), fragrant horse material (" discriminating of Heilongjiang Province Main Wild Medicinal plant and Chinese herbal medicine novel formulation "), (towards name) in very stop in east.Herb for leguminous plant melilotus.Pungent；Sweet；Micro-hardship；Cool in nature；Mild toxicity.Return liver；Spleen；Stomach warp.Clearing away summer-heat and eliminating dampness；Stomach invigorating and in.Main heat-damp in summer is uncomfortable in chest；Feeling of fullness in the head is had a headache；Dysentery；Malaria；Stranguria；Leukorrhagia；Aphtha；Halitosis；Skin infection；Eczema；Scabies；Lymphoid tuberculosis.
Herba Saginae Japonicae: another name sheep grass, loose, star show is careless, Herba Phyllanthi Urinariae.Caryophyllaceae sagina Herba Saginae Japonicae, with all herbal medicine.Bitter；Pungent；Cool in nature.Return liver；Stomach warp.Removing pathogenic heat from blood and toxic substance from the body；Killing parasites for relieving itching.Main dermatitis rhus；Tinea alba；Eczema；Erysipelas；Scrofula；Innominate toxic swelling；Venom；Nasal sinusitis；Caries pain；Internal traumatic injury.Mass dissipating and swelling eliminating, detoxifying and relieving itching.For leukemia, dermatitis rhus, carbuncle, tuberculous lymphadenitis, caries pain.
Cortex Alchorneae Davidii: another name prairie fire fiber crops.Euphorbiaceae Cortex Alchorneae Davidii, is used as medicine with stem, skin, leaf.Light, flat.Removing toxic substances, parasite killing, pain relieving.Cure mainly mad dog to bite, ascariasis, lumbago.
Cuculus polioephalus: another name Folium Rhododendri Simsii, red Cuculus polioephalus, Rhododendron simsii Planch., gorgeous mountain mountain flower red, gorgeous, clear and bright flower.For Ericaceae rhododendron Cuculus polioephalus, it is used as medicine with root, leaf and flower.Sweet in the mouth；Property is put down.GUIXIN warp.Nourish qi-restoratives；Removing toxic substances parasite killing；Promoting blood circulation and stopping pain.Main body after being ill is empty；Insufficiency of vital energy and blood；Skin ulcer fistula；Treating swelling and pain by traumatic injury；Articular instability.
Radix Seu Herba Luisiae Morsei: another name Cornu Bovis seu Bubali orchid, Herba bidentis parviflorae blue, parasitic, hang bamboo. for the orchid family Fork epidendrum Radix Seu Herba Luisiae Morsei, with all herbal medicine.Bitter；Pungent；Cool in nature；Mild toxicity. return lung；The heart；Liver；Kidney channel.Heat-clearing and toxic substances removing；Expelling wind and removing dampness.Main malaria；Carbuncle；Laryngopharynx swelling and pain；Rheumatic arthralgia；Edema；Nebulousurine；Leukorrhagia；Traumatic injury；Medicine or alimentary toxicosis.
Folium Quisqualis: another name water monarch's leaf.Medical material Ji Yuan: the leaf of Combretum Racemosum plant Fructus Quisqualis.Acrid in the mouth；Property is put down.Return spleen；Stomach warp.Regulating qi-flowing for strengthening spleen；Parasite killing detoxifies.Main distension and fullness in the abdomen；Infantile malnutrition；Malnutrition due to parasitic infestation；Furuncle ulcer
Herba Spilanthis Acmellae: call mountain Herba Spilanthis Acmellae, Herba boeae clarkeanae, umbrella button careless, golden, Cymbaria dahurica, Hemerocallis citrina Baroni Herba vallisneriae Spiralis, Herba vallisneriae Spiralis, cross Solenognathus, mountain Cortex Lycii, black joint pass.Compositae gold button platymiscium Herba Spilanthis Acmellae, with all herbal medicine.The whole year can adopt, using fresh herb or dry.Pungent, temperature.Detoxification and promoting urination, relieving cough and relieving asthma, reducing swelling and alleviating pain.For malaria, toothache, enteritis, dysentery, cough, asthma, pertussis, pulmonary tuberculosis.Venom, dog bite, carbuncle furuncle and phyma poison are controlled in external.
Yellow fluid eggplant: another name yellow fruit Corallium Japonicum Kishinouye, Radix solani coagulantis, fourth eggplant, Huang Tianqie.Solanaceae nightshade Huang Solanum aculeatissimum Jacq., is used as medicine with root, leaf and fruit.Xia Qiucaigen, leaf；Autumn and winter fruit picking；Using fresh herb or dry.Bitter, pungent, temperature.Dampness removing, detumescence, pain relieving.For rheumatic arthritis, orchitis, toothache.
Herba Glechomae: another name HUOXUEDAN, Herba Lysimachiae [Shanghai, Jiangsu], money Herba Menthae, Habenaria aitchisonii, lung-wind syndrome grass, 18 scarce, Radix seu Folium Gaultheriae Forrestiis [Sichuan].This product is the dry aerial parts of labiate HUOXUEDAN.Hardship pungent, micro-, is slightly cold.Return liver, kidney, bladder warp.Dampness removing is treating stranguria, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pyretic stranguria, stranguria caused by urinary stone, jaundice due to damp-heat, sore, carbuncle and painful swelling, injury from falling down.
Vine: call as bean (" south vegetation shape ").Zygote (supplement to the Herbal), son (" Japan hanako materia medica "), glasses bean (" the main poisonous plants in south ").Seed for leguminous plant rattan.Puckery sweet；Flat；Nontoxic.Return stomach；Liver；Large intestine channel.Promoting the circulation of QI to relieve pain, inducing diuresis and reducing edema.Main abdominal distention, jaundice, beriberi edema, dysentery, hemorrhoid, proctoptosis, sore throat
Herba Caraganae intermediae: another name horse collection bavin, Herba Damnacanthi.Medical material Ji Yuan: for the herb of leguminous plant Caragana intermedia.Sweet；Temperature.Liver；Kidney channel.Nourishing YIN and supplementing blood, invigorates blood circulation.Main menoxenia.
Radix Rhodiolae Dumulosae;Another name Rhodiola dumulosa, Herba Pteridis Multifidae, FENGHUACAO, Sedum dumulosum. medical material Ji Yuan: for herb and the root of crassulaceae plants Rhodiola dumulosa.Sweet in the mouth；Micro-hardship；Property is put down.Return kidney；Liver Channel.Kidney tonifying nourishing the liver；Regulating menstruation and activating blood.Main consumptive fever hectic fever due to YIN-deficiency；An emaciation due to blood disorder；Have a dizzy spell；Menoxenia
Herba Sambuci Chiensis: another name capsule, gallop along on horseback before, the Herba Blumeae Laciniatae, Sambucus chinensis, Flos Echinopsis latifolii, Herba rutae, severe grass, seven leaves gold.For Caprifoliaceae Sambucus plant Herba Sambuci Chiensis, it is used as medicine with root, stem and leaf.
Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus): another name Fructus Aurantii Immaturus, smelly Fructus Citri tangerinae, Chinese holly spine, wild Fructus Citri junoris, Sambucus Chinensis Lindl., Tang's Fructus Citri tangerinae, smelly Japanese raisintree fruit, smelly thorn, smelly Qi, blue or green dawn at dawn, soil Fructus Aurantii Immaturus, steel Fructus Citri tangerinae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) pears, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Lee, poplar Fructus Citri tangerinae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) pear, wild, bitter orange, Fructus Ponciri Trifoliatae, green clothing Fructus Aurantii.Medical material Ji Yuan: for rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) young fruit or immature fruit.Acrid in the mouth；Bitter；Warm in nature.Return liver；Stomach warp.Dispersing the stagnated liver-QI for regulating the stomach；Regulating QI to relieve pain；Removing food stagnancyization is stagnant.Main fullness and distention in the chest and hypochondrium；Abdominal distention；Breast lumps；Hernia pain；Painful and swollen testis；Traumatic injury；Food stagnation；Constipation；Uterine prolapse.
The Leucas ciliata Benth: for the root of labiate Herba leucadis ciliatae.Expelling wind and removing dampness；Soothing the liver removing toxic substances.Main air pain of dampness syndrome；Dysentery；Infantile malnutrition；Erythra；Proctoptosis.
Flos Mume: this product is the dry flower of rose department plant plum.Micro-acid, puckery, flat.Return liver, stomach, lung meridian.Dissipating depression of QI and in, reduce phlegm, removing toxic substances.For gloomy vexed, stomachache due to hyperactive liver-QI attacking the stomach, globus hystericus, scrofula sore.
Radix Curcumae: another name horse (Tang Materia Medica), Huang Yu (" stone medicine is elegant ").Tuber for zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Arduous, cool.1. Tang Materia Medica: " acrid in the mouth is bitter, cold, nontoxic." 2. " herbal classic is met former ": " works hard, flat, nontoxic." [return through] enters the heart, lung, Liver Channel.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control the chest and abdomen side of body all pains of rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
Embodiments provide a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, be made up of the raw medicinal material of following weight: take Herba rhynchosiae volubilis 9g, Rubus Parvifolius L. 24g, Herba Meliloti Suaveolentis 8g, Herba Saginae Japonicae 11g, Cortex Alchorneae Davidii 18g, Cuculus polioephalus 22g, Radix Seu Herba Luisiae Morsei 12g, Folium Quisqualis 26g, Herba Spilanthis Acmellae 13g, yellow fluid eggplant 15g, Herba Glechomae 19g, vine 8g, Herba Caraganae intermediae 25g, Radix Rhodiolae Dumulosae 14g, Herba Sambuci Chiensis 29g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 31g, Leucas ciliata Benth 19g, Flos Mume 39g and Radix Curcumae 23g.
The dosage form of described Chinese medicine composition is tablet, and its preparation method comprises the following steps:
The first step, mixes Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae and Cortex Alchorneae Davidii, adds relative to the alcohol reflux that mixture 4 times amount determining alcohol is 60% 3 times, each 3 hours, filtering, filtrate merges, reclaiming ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30, standby；
Second step, is mixed in proportion Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae and vine, adds relative to mixture 4 times amount water, boils 3 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.29；
3rd step, the mastic mixing first step, second step obtained, 60 DEG C of reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 2: 0.2.
Embodiment 2 Chinese medicine composition 2
Embodiments provide a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, be made up of the raw medicinal material of following weight: take Herba rhynchosiae volubilis 5g, Rubus Parvifolius L. 32g, Herba Meliloti Suaveolentis 11g, Herba Saginae Japonicae 22g, Cortex Alchorneae Davidii 14g, Cuculus polioephalus 28g, Radix Seu Herba Luisiae Morsei 7g, Folium Quisqualis 17g, Herba Spilanthis Acmellae 24g, yellow fluid eggplant 13g, Herba Glechomae 26g, vine 13g, Herba Caraganae intermediae 20g, Radix Rhodiolae Dumulosae 8g, Herba Sambuci Chiensis 34g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20g, Leucas ciliata Benth 28g, Flos Mume 32g and Radix Curcumae 17g.
The dosage form of pharmaceutical composition is powder, and its preparation method comprises the following steps:
The mixing of each crude drug score ratio by weight being broken into coarse powder, further pulverizes, cross 50 mesh sieves, enable and reaching 60% by the fine powder amount of 50 mesh sieves, the fine powder being collected by 50 mesh sieves obtains fine powder a；Will not pass through the coarse powder of 50 mesh sieves again and put into multi-function extractor extraction twice, first time adds 6 times amount soak by water 2 hours, and second time adds 5 times amount soak by water 1 hour, merges twice decocting liquid, filters to get filtrate；Heating is concentrated into pasty state, puts into cooling after 95 DEG C of baking oven is dried, grinds to form fine powder b, makes powder after being mixed by fine powder a and b.
Embodiment 3 Chinese medicine composition 3
Embodiments provide a kind of Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis, be made up of the raw medicinal material of following weight: take Herba rhynchosiae volubilis 6g, Rubus Parvifolius L. 22g, Herba Meliloti Suaveolentis 15g, Herba Saginae Japonicae 17g, Cortex Alchorneae Davidii 21g, Cuculus polioephalus 13g, Radix Seu Herba Luisiae Morsei 9g, Folium Quisqualis 23g, Herba Spilanthis Acmellae 21g, yellow fluid eggplant 26g, Herba Glechomae 12g, vine 16g, Herba Caraganae intermediae 10g, Radix Rhodiolae Dumulosae 10g, Herba Sambuci Chiensis 21g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 36g, Leucas ciliata Benth 33g, Flos Mume 28g and Radix Curcumae 31g.
The dosage form of pharmaceutical composition is powder, and its preparation method comprises the following steps:
The mixing of each crude drug score ratio by weight being broken into coarse powder, further pulverizes, cross 50 mesh sieves, enable and reaching 60% by the fine powder amount of 50 mesh sieves, the fine powder being collected by 50 mesh sieves obtains fine powder a；Will not pass through the coarse powder of 50 mesh sieves again and put into multi-function extractor extraction twice, first time adds 6 times amount soak by water 1.5 hours, and second time adds 5 times amount soak by water 2.0 hours, merges twice decocting liquid, filters to get filtrate；Heating is concentrated into pasty state, puts into cooling after 95 DEG C of baking oven is dried, grinds to form fine powder b, makes powder after being mixed by fine powder a and b.
The toxicity test of the Chinese medicine composition of the present invention
Take Herba rhynchosiae volubilis 9g, Rubus Parvifolius L. 24g, Herba Meliloti Suaveolentis 8g, Herba Saginae Japonicae 11g, Cortex Alchorneae Davidii 18g, Cuculus polioephalus 22g, Radix Seu Herba Luisiae Morsei 12g, Folium Quisqualis 26g, Herba Spilanthis Acmellae 13g, yellow fluid eggplant 15g, Herba Glechomae 19g, vine 8g, Herba Caraganae intermediae 25g, Radix Rhodiolae Dumulosae 14g, Herba Sambuci Chiensis 29g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 31g, Leucas ciliata Benth 19g, Flos Mume 39g and Radix Curcumae 23g；After mix homogeneously, pulverizing, add the water of 1200g, decoct 2.5 hours, filter in the mixture after pulverizing, the water adding 500g in filtering residue decocts 1.5 hours again, filters, and twice filtrate is mixed, is evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed.Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks.Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
The toxicity test of the Chinese medicine composition of the present invention
Take Herba rhynchosiae volubilis 5g, Rubus Parvifolius L. 32g, Herba Meliloti Suaveolentis 11g, Herba Saginae Japonicae 22g, Cortex Alchorneae Davidii 14g, Cuculus polioephalus 28g, Radix Seu Herba Luisiae Morsei 7g, Folium Quisqualis 17g, Herba Spilanthis Acmellae 24g, yellow fluid eggplant 13g, Herba Glechomae 26g, vine 13g, Herba Caraganae intermediae 20g, Radix Rhodiolae Dumulosae 8g, Herba Sambuci Chiensis 34g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20g, Leucas ciliata Benth 28g, Flos Mume 32g and Radix Curcumae 17g；After mix homogeneously, pulverizing, add the water of 1200g, decoct 2.5 hours, filter in the mixture after pulverizing, the water adding 500g in filtering residue decocts 1.5 hours again, filters, and twice filtrate is mixed, is evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed.Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks.Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
The toxicity test of the Chinese medicine composition of the present invention
Take Herba rhynchosiae volubilis 6g, Rubus Parvifolius L. 22g, Herba Meliloti Suaveolentis 15g, Herba Saginae Japonicae 17g, Cortex Alchorneae Davidii 21g, Cuculus polioephalus 13g, Radix Seu Herba Luisiae Morsei 9g, Folium Quisqualis 23g, Herba Spilanthis Acmellae 21g, yellow fluid eggplant 26g, Herba Glechomae 12g, vine 16g, Herba Caraganae intermediae 10g, Radix Rhodiolae Dumulosae 10g, Herba Sambuci Chiensis 21g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 36g, Leucas ciliata Benth 33g, Flos Mume 28g and Radix Curcumae 31g；After mix homogeneously, pulverizing, add the water of 1200g, decoct 2.5 hours, filter in the mixture after pulverizing, the water adding 500g in filtering residue decocts 1.5 hours again, filters, and twice filtrate is mixed, is evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, last is administered latter 24 hours respectively to organize to live and kills 1/2 animal (male and female half and half), and all the other 1/2 animals continuation are lived after observing 2 weeks and killed.Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology for 2 weeks.Result of the test shows: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.180,60,20 times of this test dosage respectively clinical medicine dose, rat is had no significant effect by the Chinese medicine preparation according to the result of the test present invention in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of the Chinese medicine preparation clinical practice of the prompting present invention is higher.
Contrast test
(1) for examination animal
Randomly select Jining of Shandong Province Yutai sheep plant to be diagnosed as the sick sheep 200 of Hepar Caprae seu ovis fascioliasis and be only used as treatment contrast test object；From other sheep plants, separately randomly select 80 Healthy Sheep as prevention contrast test object.
(2) prevention contrast experiment:
Randomly select 80 Healthy Sheep are randomly divided into 4 groups (embodiment group 1, embodiment group 2, embodiment group 3 and matched groups),
Wherein, matched group uses tradition sheep feedstuff to feed sheep；
Embodiment group 1 uses the Chinese medicine composition 1 added in 5kg embodiment 1 in 1000kg feedstuff to feed sheep；
Embodiment group 2 uses the Chinese medicine composition 2 added in 5kg embodiment 2 in 1000kg feedstuff to feed sheep；
Embodiment group 3 uses the Chinese medicine composition 3 added in 5kg embodiment 3 in 1000kg feedstuff to feed sheep；
After feeding one week according to the method described above, the feedstuff with worm's ovum is mixed in each group of feedstuff；Embodiment group 1-3 continues to feed medicine according to aforementioned proportion.
Observed and recorded is respectively organized sheep and is checked faecal egg, and result is as shown in table 1；
Table 1 preventive effect synopsis
| Group | Sum | The sheep number of detection worm's ovum | Detection worm's ovum sum | Protective rate |
| Embodiment group 1 | 20 | 0 | 0 | 100% |
| Embodiment group 2 | 20 | 0 | 0 | 100% |
| Embodiment group 3 | 20 | 0 | 0 | 100% |
| Matched group | 20 | 20 | 435 | 0% |
Data from table 1: Hepar Caprae seu ovis fascioliasis is had obvious preventive effect by the feedstuff that the present invention contains Chinese medicine composition.
(4) treatment contrast test:
Randomly select 200 sick sheep are randomly divided into 4 groups (embodiment group 1, embodiment group 2, embodiment group 3 and matched groups), treat with different medicines,
Wherein, embodiment group 1 selects the Chinese medicine composition 1 of embodiment 1, and dose is 0.6g/kg every day；
Embodiment group 2 selects the Chinese medicine composition 2 of embodiment 2, and dose is 0.6g/kg every day；
Embodiment group 3 selects the Chinese medicine composition 3 of embodiment 3, and dose is 0.6g/kg every day；
Matched group selects praziquantel, adopts dosage 60mg/kg, and every feed ration divides clothes between 2-3 meal.Body weight calculates by 60kg more than 60kg person.Result is as shown in table 2.
Table 2 therapeutic effect synopsis
| Group | Sum | Cure number | Faecal egg mean number (before medication) | Turn out cloudy average time (my god) | Death toll | Egg reduction rate | Negative conversion rate |
| Embodiment group 1 | 50 | 50 | 20.9 | 1.2 | 0 | 100% | 100% |
| Embodiment group 2 | 50 | 50 | 19.6 | 2.0 | 0 | 100% | 100% |
| Embodiment group 3 | 50 | 50 | 20.64 | 1.4 | 0 | 100% | 100% |
| Matched group | 50 | 48 | 19.1 | 4.8 | 2 | 99.3% | 96% |
Data from table 2: Hepar Caprae seu ovis fascioliasis therapeutic effect is substantially better than western medicine group by Chinese medicine composition of the present invention, reduce mortality rate, improve cure rate, shorten treatment time.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.
Claims (9)
1. the Chinese medicine composition being used for preventing and treating Hepar Caprae seu ovis fascioliasis, it is characterized in that, described Chinese medicine composition includes following raw medicinal material: Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae, Cortex Alchorneae Davidii, Cuculus polioephalus, Radix Seu Herba Luisiae Morsei, Folium Quisqualis, Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae, vine, Herba Caraganae intermediae, Radix Rhodiolae Dumulosae, Herba Sambuci Chiensis, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), the Leucas ciliata Benth, Flos Mume and Radix Curcumae.
null2. the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis according to claim 1，It is characterized in that，In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 5-9 weight portion、Rubus Parvifolius L. 22-32 weight portion、Herba Meliloti Suaveolentis 8-15 weight portion、Herba Saginae Japonicae 11-22 weight portion、Cortex Alchorneae Davidii 14-21 weight portion、Cuculus polioephalus 13-28 weight portion、Radix Seu Herba Luisiae Morsei 7-12 weight portion、Folium Quisqualis 17-26 weight portion、Herba Spilanthis Acmellae 13-24 weight portion、Yellow fluid eggplant 13-26 weight portion、Herba Glechomae 12-26 weight portion、Vine 8-16 weight portion、Herba Caraganae intermediae 10-25 weight portion、Radix Rhodiolae Dumulosae 8-14 weight portion、Herba Sambuci Chiensis 21-34 weight portion、Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20-36 weight portion、Leucas ciliata Benth 19-33 weight portion、Flos Mume 28-39 weight portion and Radix Curcumae 17-31 weight portion.
3. the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 9 weight portion, Rubus Parvifolius L. 24 weight portion, Herba Meliloti Suaveolentis 8 weight portion, Herba Saginae Japonicae 11 weight portion, Cortex Alchorneae Davidii 18 weight portion, Cuculus polioephalus 22 weight portion, Radix Seu Herba Luisiae Morsei 12 weight portion, Folium Quisqualis 26 weight portion, Herba Spilanthis Acmellae 13 weight portion, yellow fluid eggplant 15 weight portion, Herba Glechomae 19 weight portion, vine 8 weight portion, Herba Caraganae intermediae 25 weight portion, Radix Rhodiolae Dumulosae 14 weight portion, Herba Sambuci Chiensis 29 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 31 weight portion, the Leucas ciliata Benth 19 weight portion, Flos Mume 39 weight portion and Radix Curcumae 23 weight portion.
4. the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis according to any one of claim 1-3, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 5 weight portion, Rubus Parvifolius L. 32 weight portion, Herba Meliloti Suaveolentis 11 weight portion, Herba Saginae Japonicae 22 weight portion, Cortex Alchorneae Davidii 14 weight portion, Cuculus polioephalus 28 weight portion, Radix Seu Herba Luisiae Morsei 7 weight portion, Folium Quisqualis 17 weight portion, Herba Spilanthis Acmellae 24 weight portion, yellow fluid eggplant 13 weight portion, Herba Glechomae 26 weight portion, vine 13 weight portion, Herba Caraganae intermediae 20 weight portion, Radix Rhodiolae Dumulosae 8 weight portion, Herba Sambuci Chiensis 34 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 20 weight portion, the Leucas ciliata Benth 28 weight portion, Flos Mume 32 weight portion and Radix Curcumae 17 weight portion.
5. the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis according to any one of claim 1-4, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba rhynchosiae volubilis 6 weight portion, Rubus Parvifolius L. 22 weight portion, Herba Meliloti Suaveolentis 15 weight portion, Herba Saginae Japonicae 17 weight portion, Cortex Alchorneae Davidii 21 weight portion, Cuculus polioephalus 13 weight portion, Radix Seu Herba Luisiae Morsei 9 weight portion, Folium Quisqualis 23 weight portion, Herba Spilanthis Acmellae 21 weight portion, yellow fluid eggplant 26 weight portion, Herba Glechomae 12 weight portion, vine 16 weight portion, Herba Caraganae intermediae 10 weight portion, Radix Rhodiolae Dumulosae 10 weight portion, Herba Sambuci Chiensis 21 weight portion, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 36 weight portion, the Leucas ciliata Benth 33 weight portion, Flos Mume 28 weight portion and Radix Curcumae 31 weight portion.
6. the Chinese medicine composition of the preventing and treating Hepar Caprae seu ovis fascioliasis according to any one of claim 1-5, it is characterised in that the dosage form of described Chinese medicine composition is tablet, and its preparation method comprises the following steps:
The first step, Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae and Cortex Alchorneae Davidii are mixed, add relative to the alcohol reflux that mixture 3 times～5 times amount determining alcohol is 55%～65% 2 times～4 times, each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae and vine, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1～3: 0.15～0.3.
7. the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis according to any one of claim 1-5, it is characterised in that the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The mixing of each crude drug score ratio by weight being broken into coarse powder, further pulverizes, cross 50 mesh sieves, enable and reaching 60% by the fine powder amount of 50 mesh sieves, the fine powder being collected by 50 mesh sieves obtains fine powder a；Will not pass through the coarse powder of 50 mesh sieves again and put into multi-function extractor extraction twice, first time adds 6 times amount soak by water 1.5-2 hour, and second time adds 5 times amount soak by water 1-2.0 hour, merges twice decocting liquid, filters to get filtrate；Heating is concentrated into pasty state, puts into cooling after 95 DEG C of baking oven is dried, grinds to form fine powder b, makes powder after being mixed by fine powder a and b.
8. the preparation method of the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis as described in any one of claim 1-5, it is characterised in that the dosage form of described Chinese medicine composition is tablet, and its preparation method comprises the following steps:
The first step, Herba rhynchosiae volubilis, Rubus Parvifolius L., Herba Meliloti Suaveolentis, Herba Saginae Japonicae and Cortex Alchorneae Davidii are mixed, add relative to the alcohol reflux that mixture 3 times～5 times amount determining alcohol is 55%～65% 2 times～4 times, each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion Herba Spilanthis Acmellae, yellow fluid eggplant, Herba Glechomae and vine, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1～3: 0.15～0.3.
9. the preparation method of the Chinese medicine composition for preventing and treating Hepar Caprae seu ovis fascioliasis as described in any one of claim 1-5, it is characterized in that, the dosage form of described Chinese medicine composition is powder, its preparation method comprises the following steps: the mixing of each crude drug score ratio by weight is broken into coarse powder, further pulverize, crossing 50 mesh sieves, enable and reaching 60% by the fine powder amount of 50 mesh sieves, the fine powder being collected by 50 mesh sieves obtains fine powder a；Will not pass through the coarse powder of 50 mesh sieves again and put into multi-function extractor extraction twice, first time adds 6 times amount soak by water 1.5-2 hour, and second time adds 5 times amount soak by water 1-2.0 hour, merges twice decocting liquid, filters to get filtrate；Heating is concentrated into pasty state, puts into cooling after 95 DEG C of baking oven is dried, grinds to form fine powder b, makes powder after being mixed by fine powder a and b.
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| CN112753858A (en) * | 2021-01-22 | 2021-05-07 | 中国热带农业科学院热带作物品种资源研究所 | Feed composition for improving feed intake of black goats and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103893696A (en) * | 2014-03-15 | 2014-07-02 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicinal composition for treating hepatic fascioliasis of cattle and sheep and preparation method thereof |
| CN104258199A (en) * | 2014-09-19 | 2015-01-07 | 山东新希望六和集团有限公司 | Traditional Chinese medicinal composition for preventing and treating white muscle disease of sheep and preparation method thereof |
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| CN103893696A (en) * | 2014-03-15 | 2014-07-02 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicinal composition for treating hepatic fascioliasis of cattle and sheep and preparation method thereof |
| CN104258199A (en) * | 2014-09-19 | 2015-01-07 | 山东新希望六和集团有限公司 | Traditional Chinese medicinal composition for preventing and treating white muscle disease of sheep and preparation method thereof |
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| CN112753858A (en) * | 2021-01-22 | 2021-05-07 | 中国热带农业科学院热带作物品种资源研究所 | Feed composition for improving feed intake of black goats and preparation method thereof |
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