CN103007111B - Chinese medicinal preparation for treating diarrhea of rabbits and preparation method of Chinese medicinal preparation - Google Patents
Chinese medicinal preparation for treating diarrhea of rabbits and preparation method of Chinese medicinal preparation Download PDFInfo
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Abstract
The invention provides a Chinese medicinal preparation for treating diarrhea of rabbits. The Chinese medicinal preparation comprises common andrographis herb, pomegranate bark, herba patriniae, garden burnet, Chinese pulsatilla root, Chinese angelica, common bletilla tuber, allium macrostemon, focal divine comedy, bighead atractylodes rhizome, dried rehmannia, oldenlandia diffusa, dandelion, coptis chinensis, ash barks, pericarpium arecae, dangshen root, scutellaria baicalensis, rhizoma smilacis glabrae and sweet wormwood. In order to solve the problem that rabbits are easily subjected to diarrhea during feeding, a Chinese medicinal addictive for eliminating dampness, strengthening the spleen and the stomach, supplementing middle-jiao and tonifying the qi and enhancing premonition is added, so that bacteria are killed and inhibited directly, the immunity organism can be adjusted, and the preparation has a nonspecific antibacterial action and avoids dependency; the growth of the rabbits also can be promoted; the damage to the rabbits caused by chemical antibiotics is eliminated; the side effect of the food security is indirectly influenced; and the brand new Chinese medicinal addictive is used, so that the requirement on pure natural green food is met.
Description
Technical field
The present invention relates to a kind of with animal, plant as the Chinese medicine preparation of raw material production, particularly a kind ofly treat Chinese medicine preparation of rabbit diarrhoea and preparation method thereof.
Background technology
In the breeding process of rabbit, diarrhoea is one of modal disease, and its onset speed is very fast, and pathogenic factor is complicated, is the Etiological causing the rabbit death of the young north to the Great Wall.Therefore, the diarrhoea of north to the Great Wall rabbit must have been prevented, accomplish early to find, early treatment.
The reason of 1 diarrhoea
North to the Great Wall rabbit diarrhoeal diseases causes primarily of antibacterial, virus, fungus, toxin, parasite and biological paathogenic factor, and feedstuff and the improper digestive disorders caused of feeding and management are also the modal causes of disease.
The diarrhoea that 1.1 dyspepsias cause
Rabbit is multiple in the more than 1 monthly age young north to the Great Wall, and main manifestations is for defecation is frequent, loose and watery stool is soft, in medicated porridge sample or watery stool, and spirit is depressed, loss of appetite, become thin gradually, blood or gel-shaped mucus is mixed with in serious sick rabbit watery diarrhea thing, conjunctiva cyanosis, rapid breathing, normal collapse and dead.
The diarrhoea that 1.2 bacteriological infection cause
Acute or the chronic disease that Escherichia coli and toxin thereof cause.Mainly betide the young rabbit of 25-70 age in days, rabbit of falling ill shows as diarrhoea or constipation, and what have is watery diarrhea, often has gel-shaped mucus in feces.When feeding and management is improper or weather drastic change time, north to the Great Wall rabbit body resistance decline, escherichia coli quantity can sharply increase, thus cause morbidity.The acute infectious disease of the digestive tract that the extracellular toxin of A type clostridieum welchii causes, its sickness rate, mortality rate are all higher.The equal susceptible of rabbit at each kind, age, wherein the young rabbit invasion rate at 1-3 monthly age is high.The diarrhoea that salmonellosis causes mainly betides young north to the Great Wall rabbit and conceived 25 days later female rabbits.
The diarrhoea that 1.3 viral infection cause
Transmissible gastroenteritis is acute infectious intestinal disease.Main manifestations is anorexia and diarrhoea, especially in cold season, can infect rapidly the rabbit at various age, and the young rabbit of 20-30 age in days serious de-water and eletrolytes often occurs and loses, and case fatality rate is higher.Young rabbit case fatality rate more than 3 monthly ages is lower.Epidemic diarrhea infectious intestinal disease, not only betides young rabbit, and also has generation at adult rabbits, and infection rate is 100%, and the M & M of the Tu Heyou north to the Great Wall, young north to the Great Wall rabbit is all higher.Clinical manifestation is row's watery stools and dehydration, and annual each Ji Junke occurs.
The diarrhoea that 1.4 parasitic infection cause
The internal parasitic disease caused by multiple coccidiosis.Clinically to become thin, anemia, hemafecia and growth retardation be feature.Mainly infect the most serious with the Tu Heyou north to the Great Wall, the young north to the Great Wall rabbit of 20-70 age in days.
Diarrhoea rabbit general abdominal part expands, hypourocrinia and in canescence, gastrointestinal peristalsis strengthens, and has seasonal disease north to the Great Wall rabbit to present stomachache.Sick north to the Great Wall rabbit down in spirits, astasia is weak, body temperature raises, by hair slightly disorderly, poor appetite or absolutely useless, and there is diarrhoea, start as yellow loose stool, anaphase transition is taupe or black watery stools, have just in band blood or have open-minded film, taste is smelt as of rotten fish, most of sick north to the Great Wall rabbit hind leg, anus and afterbody are polluted by hair, anus blocking serious individually.Disease north to the Great Wall rabbit coolness of extremities, eye socket sink, and becomes thin rapidly, death in 2-3 days after general morbidity, the sustainable 5-7 days of some courses of disease.
Rabbit is plant-eating animal, and the Ying Yicao that feeds is main, and concentrate is auxiliary, suitable benefit is with coarse fodder, and be strictly on guard against that concentrate is too much or crude fiber content is little, this point is easily out in the cold, though crude fibre is little easy to digest, but can gastrointestinal tract be filled, stimulating gastrointestinal road mucosa, safeguard intestinal smooth muscle system tonicity, reduce caecum, colon load, avoid food to form agglomerate in gastrointestinal and cause enteritis to occur diarrhoea, in daily ration, crude fiber content should maintain within the scope of 12-6%.Although feeding antibiotic class medicine has greatly promoted the development of aquaculture, and be described as the milestone of animal nutrition in this century, but the abuse of antibiotics problem of spreading out more bad and more bad in recent years, not only have impact on feeding antibiotic drug effect and livestock products quality, and negative effect is created to the consumer psychology of masses.
Medical herbs is chosen to be safe feed additive, follow Traditional Chinese Medicine theory and modem animal threpsology principle always, have with food homology, consubstantiality, with feature, have the dual function of nutrition and medicine concurrently, its immunity substance mass-energy enhancing human body immunity function, improve animal anti-stress, anti-disease ability, improve breeding performonce fo animals, go back simultaneously toxic side effect little, have no drug resistance, the not easily advantage such as residual.Facts have proved, Chinese herbal feed additive is applied to during north to the Great Wall rabbit is raised and can effectively increases the number of heads of livestock for sale, and survival rate, improves north to the Great Wall Carnis Leporis mouthfeel, can directly affect ecological benefits, economic benefit and social benefit.
Chinese herbal feed additive, refer to and to take as the leading factor with the traditional theory of China to the physical property of large so Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (sour, sweet, bitter, peppery, salty) and material relation and with the subjects theory such as raising and feed industry and technology for support, the single and compound Chinese herbal medicine additive developed or intermixture.
Due to many drawbacks of feeding antibiotic class and chemical synthetic drug additive, countries in the world every year all in control its dosage applied in animal husbandry and kind, simultaneously at the feed additive trying to explore other safety and environmental protection type.Present rabbit meat poor hygienic, domestic standard and international standard disunity, drug residue exceeds standard, and quality does not reach importer and requires it is keeping in check of restriction China's Carnis Leporis development.China is main mainly with supporting rabbit on a small scale, abuses medicine, abuses antibiotic phenomenon general.Although made the medicine residual standard much meeting international standard in recent years, and constantly the use of specification feed additive specifies, but the consciousness at our detection method, monitoring system and foster rabbit family relatively lags behind, add poor management, become Carnis Leporis outlet and domestic hidden danger, greatly reduce the market competitiveness of China's Carnis Leporis.
Summary of the invention
Technical problem to be solved by this invention is, for China's aquaculture to support rabbit on a small scale, abuses medicine, abuses antibiotic phenomenon general; And the consciousness at the existing detection method of China, monitoring system and foster rabbit family relatively lags behind, add poor management, become Carnis Leporis outlet and domestic all undesirable, greatly reduce the shortcoming of the market competitiveness of China's Carnis Leporis, adopt brand-new Chinese medicine additive, reach the requirement of pollution-free food pure natural; Develop a kind of pure Chinese medicinal preparation for the treatment of rabbit diarrhoea, to solve above-mentioned technical barrier.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of rabbit diarrhoea, in described Chinese medicine preparation, each crude drug comprises: Herba Andrographis, Pericarpium Granati, Herba Patriniae, Radix Sanguisorbae, the Radix Pulsatillae, Radix Angelicae Sinensis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Allii Macrostemonis, Massa Medicata Fermentata (parched to brown), the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Herba Hedyotidis Diffusae, Herba Taraxaci, Rhizoma Coptidis, Cortex Fraxini, Pericarpium Arecae, Radix Codonopsis, Radix Scutellariae, Rhizoma Smilacis Glabrae and Herba Artemisiae Annuae.
The Chinese medicine preparation of described treatment rabbit diarrhoea, in described Chinese medicine preparation, the ratio of weight and number of each crude drug can be preferably: Herba Andrographis 10 ~ 20 weight portion, Pericarpium Granati 10 ~ 20 weight portion, Herba Patriniae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, the Radix Pulsatillae 10 ~ 20 weight portion, Radix Angelicae Sinensis 10 ~ 20 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 weight portion, Bulbus Allii Macrostemonis 10 ~ 20 weight portion, Massa Medicata Fermentata (parched to brown) 10 ~ 20 weight portion, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portion, the Radix Rehmanniae 10 ~ 20 weight portion, Herba Hedyotidis Diffusae 10 ~ 20 weight portion, Herba Taraxaci 10 ~ 20 weight portion, Rhizoma Coptidis 10 ~ 20 weight portion, Cortex Fraxini 10 ~ 20 weight portion, Pericarpium Arecae 10 ~ 20 weight portion, Radix Codonopsis 10 ~ 20 weight portion, Radix Scutellariae 10 ~ 20 weight portion, Rhizoma Smilacis Glabrae 10 ~ 20 weight portion and Herba Artemisiae Annuae 10 ~ 20 weight portion.
The Chinese medicine preparation of described treatment rabbit diarrhoea, in Chinese medicine preparation described in it, the ratio of weight and number of each crude drug can also be preferably: Herba Andrographis 10 ~ 15 weight portion, Pericarpium Granati 10 ~ 15 weight portion, Herba Patriniae 10 ~ 15 weight portion, Radix Sanguisorbae 10 ~ 15 weight portion, the Radix Pulsatillae 10 ~ 15 weight portion, Radix Angelicae Sinensis 10 ~ 15 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 weight portion, Bulbus Allii Macrostemonis 10 ~ 15 weight portion, Massa Medicata Fermentata (parched to brown) 10 ~ 15 weight portion, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 weight portion, the Radix Rehmanniae 10 ~ 15 weight portion, Herba Hedyotidis Diffusae 10 ~ 20 weight portion, Herba Taraxaci 10 ~ 20 weight portion, Rhizoma Coptidis 10 ~ 20 weight portion, Cortex Fraxini 10 ~ 20 weight portion, Pericarpium Arecae 10 ~ 20 weight portion, Radix Codonopsis 10 ~ 20 weight portion, Radix Scutellariae 10 ~ 20 weight portion, Rhizoma Smilacis Glabrae 10 ~ 20 weight portion and Herba Artemisiae Annuae 10 ~ 20 weight portion.
The Chinese medicine preparation of described treatment rabbit diarrhoea, in Chinese medicine preparation described in it, the ratio of weight and number of each crude drug also can be preferably: Herba Andrographis 10 ~ 20 weight portion, Pericarpium Granati 10 ~ 20 weight portion, Herba Patriniae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, the Radix Pulsatillae 10 ~ 20 weight portion, Radix Angelicae Sinensis 10 ~ 20 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 weight portion, Bulbus Allii Macrostemonis 10 ~ 20 weight portion, Massa Medicata Fermentata (parched to brown) 10 ~ 20 weight portion, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portion, the Radix Rehmanniae 10 ~ 20 weight portion, Herba Hedyotidis Diffusae 10 ~ 15 weight portion, Herba Taraxaci 10 ~ 15 weight portion, Rhizoma Coptidis 10 ~ 15 weight portion, Cortex Fraxini 10 ~ 15 weight portion, Pericarpium Arecae 10 ~ 15 weight portion, Radix Codonopsis 10 ~ 15 weight portion, Radix Scutellariae 10 ~ 15 weight portion, Rhizoma Smilacis Glabrae 10 ~ 15 weight portion and Herba Artemisiae Annuae 10 ~ 15 weight portion.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of rabbit diarrhoea, and the preparation process of Chinese medicine preparation described in it is: first shredded, refine into fine powder by the crude drug of described Chinese medicine additive; Mix Mel again to granulate, put into granulator and granulate.
The preparation method of the Chinese medicine preparation for the treatment of rabbit diarrhoea, when described Chinese medicine preparation makes granule, when molding is granulated, granule is the cylinder of diameter 1cm ~ 2cm.
The preparation method of Chinese medicine preparation of described treatment rabbit diarrhoea, its preparation process can be: the first step first by described crude drug by described ratio of weight and number co-grinding, mistake 100 ~ 120 mesh sieves, after sieving, fine powder is for subsequent use.
The preparation method of the Chinese medicine preparation of described treatment rabbit diarrhoea, its preparation process can be: unsifted coarse granule medicine adds in the ethanol of weight portion 10 times by second step, heating and refluxing extraction 3 times, each 1 ~ 2 hour, filtrate is merged, obtains medicinal liquid, by medicinal liquid stand for standby use; Extract medicinal liquids by above-mentioned three times to merge, being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.05MPa, temperature remains on the extractum of 70-80 DEG C, extractum is put into oven for drying and makes powdered medicaments.
The preparation method of the Chinese medicine preparation of described treatment rabbit diarrhoea, its preparation process can be: the medicated powder obtained after refinement mixes with the fine powder sieved by the 3rd step; The medicated powder mixed adds proper honey and stirs into pasty state, puts into granulator and granulates.
The Chinese medicine preparation of described treatment rabbit diarrhoea, preparation formulation described in it can be granule, powder, plaster or ointment; Can mix in concentrated feed during use or Direct-fed.
The present invention is directed to during rabbit is raised and easily send out diarrhoea, add and go dampness, the Chinese medicine additive of strengthening the spleen and stomach, invigorating the spleen and replenishing QI, enhancing premunition; Not only can direct bactericidal, and the immune function of body can be regulated, there is non-specific antibacterial action, and do not produce dependency; Can also promote that rabbit grows, abandon the injury of chemobiotic to rabbit body, the side effect of remote-effects food safety, adopt brand-new Chinese medicine additive, reach the requirement of pollution-free food pure natural.Selected Chinese herbal medicine, not only containing abundant aminoacid, vitamin, trace element and unknown growth regulator, directly can promote the digestibility and utilization of nutrient substance, especially to the targeted curative effect of the diarrhoea of rabbit.Chinese herbal medicine additive can improve digestibility, the utilization rate of nutrient substance, strengthens the metabolism of poultry, blood circulation promoting, improves the speed of growth.
Detailed description of the invention
In the raising of rabbit, diarrhoea is the arch-criminal causing the rabbit rate of animals delivered to the slaughter-house low always.And use antibiotic in a large number, cause again rabbit meat health not up to standard, drug residue exceeds standard, and quality does not reach importer's requirement, becomes vicious cycle.The scale of the existing fr raising rabbits of China is less, and the phenomenon abusing medicine is general.Although made the medicine residual standard the use regulation of continuous specification feed additive that much meet international standard in recent years, but the consciousness at our detection method, monitoring system and foster rabbit family relatively lags behind, add poor management, become Carnis Leporis outlet and domestic hidden danger.
Not only self can kill Chinese herbal medicine or the pathogenic microorganism such as anti-bacteria or parasite, also non-specific all active factors antimicrobial of adjustable motivation body are comprehensive kills or suppresses pathogenic microorganism, search to the bottom, namely reach anti-microbial effect from enhancing body organ-tissue antibacterial ability and structure metabolism two aspect acting on antibacterial.As, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci etc. have broad-spectrum antibacterial action; The tool antivirus actions such as Rhizoma Coptidis, Radix Isatidis, Flos Lonicerae; The tool antifungic actions such as Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Cortex Dictamni; The anti-spirillum effect of tool such as Artemisia annua L., the Radix Rehmanniae, Cortex Phellodendri; Folium Isatidis has the effect of the pathogenetic bacterias such as anti-dysentery bacterium, meningococcus and leptospira; Fructus Capsici has anti-Staphylococcus aureus, escherichia coli, bacillus subtilis and aspergillus niger, penicillium sp effect.Little Sang alkali in Rhizoma Coptidis, Cortex Phellodendri has significant inhibition to multiple gram positive bacteria and negative bacterium, is especially strong to the bacteriostasis of dysentery bacterium, staphylococcus aureus; Chinese medicine formula Cortex Fraxini, Rhizoma Atractylodis, Cortex Phellodendri, the Radix Pulsatillae etc. effectively can prevent and treat Pullorum Disease to Salmonella obvious inhibitory or killing effect, according to another report, add 1% Chinese herbal compound preparation in daily ration and there is stronger anticoccidial effect, and add comparatively that short-term additive effect is better for a long time.
Chinese herbal medicine itself is not hormone, but can play the regulating action similar to hormone to body, and can prevent. stop, alleviate or eliminate the toxic and side effects of exogenous hormone.As, the tool estrogen-like effectss such as Rhizoma Cyperi, Radix Angelicae Sinensis, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Cnidii; The tool androgen-like action such as excessive sheep mat, Radix Ginseng, Cordyceps: the tool epinephrine sample effects such as Herba Asari, Radix Aconiti Lateralis Preparata, Fructus Evodiae, Rhizoma Alpiniae Officinarum, Fructus Schisandrae Chinensis; The tool thyroliberin sample effect such as Cornu Bubali, Herba Andrographis, Radix Tripterygii Wilfordii; The carbamylmethylcholine sample effects such as Semen Ziziphi Spinosae, Fructus Lycii, Bulbus Allii.
The general abdominal part of sick rabbit expands, hypourocrinia and in canescence, gastrointestinal peristalsis strengthens, and has seasonal disease rabbit to present stomachache.Sick rabbit down in spirits, astasia is weak, body temperature raises, by hair slightly disorderly, poor appetite or absolutely useless, and there is diarrhoea, start as yellow loose stool, anaphase transition is taupe or black watery stools, have just in band blood or have open-minded film, taste is smelt as of rotten fish, most of sick rabbit hind leg, anus and afterbody are polluted by hair, anus blocking serious individually.Disease rabbit coolness of extremities, eye socket sink, and becomes thin rapidly, death in 2-3 days after general morbidity, the sustainable 5-7 days of some courses of disease, and this becomes raises the topmost loss in family.
Rabbit is plant-eating animal, and the Ying Yicao that feeds is main, and concentrate is auxiliary, suitable benefit is with coarse fodder, and be strictly on guard against that concentrate is too much or crude fiber content is little, this point is easily out in the cold, though crude fibre is little easy to digest, but can gastrointestinal tract be filled, stimulating gastrointestinal road mucosa, safeguard intestinal smooth muscle system tonicity, reduce caecum, colon load, avoid food to form agglomerate in gastrointestinal and cause enteritis to occur diarrhoea, in daily ration, crude fiber content should maintain within the scope of 12-6%.
Medical herbs is chosen to be safe feed additive, follow Traditional Chinese Medicine theory and modem animal threpsology principle always, have with food homology, consubstantiality, with feature, have the dual function of nutrition and medicine concurrently, its immunity substance mass-energy enhancing human body immunity function, improve animal anti-stress, anti-disease ability, improve breeding performonce fo animals, go back simultaneously toxic side effect little, have no drug resistance, the not easily advantage such as residual.Facts have proved, Chinese herbal feed additive is applied to during rabbit is raised and can effectively increases the number of heads of livestock for sale, and survival rate, improves Carnis Leporis mouthfeel, can directly affect ecological benefits, economic benefit and social benefit.
Specific embodiment 1: get Herba Andrographis 1000g, Pericarpium Granati 1000g, Herba Patriniae 1000g, Radix Sanguisorbae 1000g, Radix Pulsatillae 1000g, Radix Angelicae Sinensis 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Bulbus Allii Macrostemonis 1000g, Massa Medicata Fermentata (parched to brown) 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Rehmanniae 1000g, Herba Hedyotidis Diffusae 1000g, Herba Taraxaci 1000g, Rhizoma Coptidis 1000g, Cortex Fraxini 1000g, Pericarpium Arecae 1000g, Radix Codonopsis 1000g, Radix Scutellariae 1000g, Rhizoma Smilacis Glabrae 1000g and Herba Artemisiae Annuae 1000g and make granule.
Specific embodiment 2: get Herba Andrographis 1000g, Pericarpium Granati 1000g, Herba Patriniae 1000g, Radix Sanguisorbae 1000g, Radix Pulsatillae 1000g, Radix Angelicae Sinensis 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Bulbus Allii Macrostemonis 1000g, Massa Medicata Fermentata (parched to brown) 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Rehmanniae 1000g, Herba Hedyotidis Diffusae 1000g, Herba Taraxaci 1000g, Rhizoma Coptidis 1000g, Cortex Fraxini 1000g, Pericarpium Arecae 1000g, Radix Codonopsis 1000g, Radix Scutellariae 1000g, Rhizoma Smilacis Glabrae 1000g and Herba Artemisiae Annuae 1000g, first described crude drug is pressed described ratio of weight and number co-grinding, cross 100 ~ 120 mesh sieves, after sieving, fine powder is for subsequent use, again ratio of weight and number described in unsifted coarse granule is added in the ethanol of weight portion 10 times, heating and refluxing extraction 3 times, each 1 ~ 2 hour, filtrate is merged, obtain medicinal liquid, by medicinal liquid stand for standby use, extract medicinal liquids by above-mentioned three times to merge, being concentrated into liquor strength is 0.8g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06, be decompressed to 0.03-0.06MPa, temperature remains on the extractum of 70-80 DEG C, extractum is put into oven for drying and makes powdered medicaments, mix twice medicated powder and mix Mel, put into the granule that granulator makes 1-2 centimetre.
Specific embodiment 3: get Herba Andrographis 1000g, Pericarpium Granati 1000g, Herba Patriniae 1000g, Radix Sanguisorbae 1000g, Radix Pulsatillae 1000g, Radix Angelicae Sinensis 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Bulbus Allii Macrostemonis 1000g, Massa Medicata Fermentata (parched to brown) 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Rehmanniae 1000g, Herba Hedyotidis Diffusae 1000g, Herba Taraxaci 1000g, Rhizoma Coptidis 1000g, Cortex Fraxini 1000g, Pericarpium Arecae 1000g, Radix Codonopsis 1000g, Radix Scutellariae 1000g, above-mentioned raw materials medical material was shredded 100 ~ 120 mesh sieves by Rhizoma Smilacis Glabrae 1000g and Herba Artemisiae Annuae 1000g, after sieving, fine powder is for subsequent use, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, stain 20 days together with more than 70 degree ethanol, the coarse granule medicinal residues flooded are carried out squeezing and pulverize filtration, filtrate is got after separation, described filtrate heating is concentrated into pasty state, puts into drying in oven, after cooling, grind to form fine powder, add the above-mentioned fine powder sieved, be mixed into powder, mix twice medicated powder and become powder.
Specific embodiment 4: first by crude drug Herba Andrographis 1000g, Pericarpium Granati 1000g, Herba Patriniae 1000g, Radix Sanguisorbae 1000g, Radix Pulsatillae 1000g, Radix Angelicae Sinensis 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Bulbus Allii Macrostemonis 1000g, Massa Medicata Fermentata (parched to brown) 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Rehmanniae 1000g, Herba Hedyotidis Diffusae 1000g, Herba Taraxaci 1000g, Rhizoma Coptidis 1000g, Cortex Fraxini 1000g, Pericarpium Arecae 1000g, Radix Codonopsis 1000g, Radix Scutellariae 1000g, Rhizoma Smilacis Glabrae 1000g and Herba Artemisiae Annuae 1000g, shredded 100 ~ 120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, stain 15 ~ 30 days together with more than 90 degree ethanol, the liquid flooded and medicinal residues are carried out squeeze and filter, filtrate is got after separation, by concentrated for the heating of described filtrate, when the relative density of filtrate is about 20 DEG C 1.06, be decompressed to 0.03-0.06MPa, temperature remains on the extractum of 70-80 DEG C, makes extractum.
The various property of Chinese materia medica in Chinese medicine additive:
Its sweet in the mouth of Radix Angelicae Sinensis and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
The Radix Astragali, can invigorating QI to consolidate the body surface resistance based on tonify deficiency, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.
The Rhizoma Atractylodis Macrocephalae can strengthen shrinkage amplitude, the contraction frequency of intestinal smooth muscle significantly, extends intestinal smooth muscle contraction time under anaerobic conditions, and adjustment gastrointestinal motility function, has antiulcer, protects the liver the effect with enhancing human body immunity function.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Energy main large migratory arthralgia, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out only.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.
Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Dandelion Compositae belongs to herbaceos perennial.It is the plant of dietotherapeutic.Record according to Compendium of Material Medica, the flat sweet and slightly bitter taste of its property, has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and galgctogogue action, very effective to treatment mastitis.No matter decoct juice oral, or smash to mud external application, all there is effect.In addition, Herba Taraxaci also has the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, is widely used in clinical.Compendium of Material Medica has a cloud: " the tender Seedling of Herba Taraxaci is edible, eats that to control infectious disease especially good raw." Shennong's Herbal, Tang Materia Medica, the successive dynasties Medical monographs such as " Chinese medicine voluminous dictionary " all give high evaluation.
Herba Artemisiae Annuae is feverfew Herba Artemisiae annuae Artemisia annua L. dry aerial parts.Herba Artemisiae Annuae clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.It is a kind of antimalarial drug of cheapness.Herba Artemisiae Annuae decocting liquid has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc.Herba Artemisiae Annuae volatile oil, when 0.25% concentration, has bacteriostasis to all dermatophytosises, when 1% concentration, has bactericidal action to all dermatophytosises.Herba Artemisiae Annuae have the effect of resisiting influenza virus.Sodium artesunate is to golden Fructus Vitis viniferae, shigella flexneri, escherichia coli, micrococcus catarrhalis, and A type and paratyphoid B stalk bacterium all have certain antibacterial action.Sitosterol in Herba Artemisiae Annuae and stigmasterol also have antivirus action.
Pseudobulbus Bletillae (Rhizoma Bletillae) tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis." herbal classic ": " main carbuncle malignant boil loses cellulitis, the dead flesh of impairment of YIN, pathogen in stomach, and harmful wind miliaria is slow not to be received." antibacterial, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; Water logging agent has inhibitory action to microsporon audouini; 3 biphenyl classes contained by Pseudobulbus Bletillae (Rhizoma Bletillae) and 2 luxuriant and rich with fragrance compounds of two hydrogen have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans ATCC1057 and Trichophyton QM248.
Cortex Fraxini English name: CORTEX FRAXINI.Latin plant animal mineral name: Fraxinus rhynchophylla Hance F.Chinensis Roxb.var.rhynchopylla (Hance) Hemsl.] and nature and flavor hardship, cold.Heat clearing and damp drying Chinese medicine.Cure mainly: heat clearing and damp drying, liver heat removing and eyesight improving, antiasthmatic-antitussive.For pyretic toxicity dysentery, conjunctival congestion and swelling pain, the raw cataracta of order.Antibacterial action: Cortex Fraxini decoct pastille flat band method, 1:50 is to staphylococcus aureus, dysentery bacterium, 1:20 has inhibitory action to escherichia coli etc. and in vitro tests shows, Cortex Fraxini is inhibited to various bacteria such as staphylococcus epidermidis, micrococcus catarrhalis, bacillus pyocyaneus. anti-inflammatory and analgesic effect: eaculin has inhibitory action to experimental arthritis, and have faint analgesic activity.
Its Chinese patent medicine bitter in the mouth of Herba Hedyotidis Diffusae, light, cold in nature.Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation.In clinical practice, if find, Herba Hedyotidis Diffusae compatibility is proper, can treat various diseases.
Rhizoma Smilacis Glabrae detoxicating and resolving stagnation of pathogens, dispelling wind and removing obstruction in the collateral, dampness removing is let out turbid.Cure mainly syphilis, sore throat, carbuncle malignant boil, scrofula, carcinoma, muscles and bones spasm and pain, edema, stranguria with turbid discharge, beriberi of having loose bowels, eczema scabies, mercurialism." detailed outline ": strengthening the spleen and stomach, bone and muscle strengthening, curing rheumatism, sharp joint, stopping leak rushes down.Control contracture osteodynia; Malignant boil carbuncle.Separate hydrargyrum powder, Vermilion poison.
Herba Patriniae heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.For acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle pain is swollen, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea.Also feed stripped can be made.Herba Ixeritis chinensis belongs to medium herbage.The tender succulence of stem and leaf, sheep, goat eating when green grass or young crops is fresh.According to herdsman's reflection, it has to little poultry effect of fattening spring.Cattle, horse also search for food on a small quantity, but can not utilize after drying up.In addition, it is still raised pigs, supports rabbit, supports the good feedstuff of fowl.Its nutritive value is also higher, according to analysis, contains higher thick protein and the crude fibre of relatively low amount at flowering fruit bearing stage.In various amino acid whose content, higher with the content of lysine, threonine, valine.Containing vitamin C 7018 milligrams in 100 grams of herbs.
Pericarpium Arecae formal name used at school: Pericarpium Arecae (drawing); For the dry peel of babassu Semen Arecae Areca catechu L..Acrid in the mouth; Slightly warm in nature.Return spleen; Stomach; Large intestine; Small intestine meridian.Modern study, these product have excited gastrointestinal smooth muscle, short digestive tract power effect, and have effects such as promoting fibrinolysis." Kaibao Bencao ": main cold and hot gas is made a psychological attack abdomen, and large intestine stops up poison, expectorant diaphragm, the belching of acid from stomach.And decoct with Jiang Yantong, enter thin gas medicine good." detailed outline ": lowering the adverse flow of QI, aqueous vapor edema in the skin that disappears, beriberi is stopped up inverse, subtertian malaria feeling of fullness, nausea malignant histocytosis feeling of distension and oppression." book on Chinese herbal medicine is new again ": eliminating the pathogens from the lung, easing stomach-QI, dampness removing chases after wind, wide intestinal detumescence, reason waist beriberi, treating malaria disease dysentery.
Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.The diseases such as, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., the card of retention of damp-heat in the interior can be controlled.Be reluctant to leave the intestines and stomach to damp and hot, often coordinate the Rhizoma Pinelliae, Caulis Bambusae In Taenia; Join the Radix Aucklandiae, Radix Scutellariae, Radix Puerariae etc. to control dysentery.
Herba Andrographis has heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom." Guangxi Chinese herbal medicine ": hemostasis removing heat from blood, removing toxic substances and promoting tissue regeneration, controls lung abscess, stomatitis.
Effect that Radix Rehmanniae has clearing away heat and cooling blood, tonifying YIN promotes the production of body fluid.The evaluation of Li Shizhen (1518-1593 A.D.) to Radix Rehmanniae is: " one hundred days of clothes are rosy cheeks, within 3 years, make light of one's life by commiting suicide not old." Radix Rehmanniae heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; Fresh Radix Rehmanniae sweet in the mouth bitterness Great Cold, act on similar to Radix Rehmanniae, the power of YIN nourishing is slightly inferior, but clearing away heat and promoting production of body fluid, the power of cooling blood for hemostasis is stronger.
Massa Medicata Fermentata is the processed goods through fermentation after whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, the buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mixing.Get Massa Medicata Fermentata to put in pot and fry to appearance be coke black, inner coke yellow, take out, sprinkling disappears water, cools, is Massa Medicata Fermentata (parched to brown).Massa Medicata Fermentata forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, and therefore, bad, feeling of stuffiness in chest abdominal distention for the digestion caused by diet internal injury quite have effect.
Radix Sanguisorbae property of medicine picric acid; Cold; Nontoxic, return liver; Lung; Kidney; Large intestine channel, effect cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Effect classification hemorrhage; Blood-cooling hemostatic.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, controls defecation blood disorder.Hemostasis, get and cut off sheet and fry use, its tip then can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.
Pericarpium Granati has relieving diarrhea with astringents, hemostasis, effect of anthelmintic." property of medicine opinion " carries it: " control muscles and bones wind, waist foot is unsuccessful, the anxious pain of walking contraction.Main astringing intestine to stop diarrhea, only red white dysentery.Under extracting juice stops order tear, control Lou essence." supplement to the Herbal carries it: " main ascarid.Decoction." " the southern regions of the Yunnan Province book on Chinese herbal medicine " carries it: " controls with the passing of time watery diarrhea, simmering clothes, controlling again dysentery pus and blood, large intestine hematochezia with frying Saccharum Sinensis Roxb.." " is decocted with Fructus Aristolochiae and is controlled children's's infantile malnutrition worm." experiment in vitro shows: Pericarpium Granati is to escherichia coli, bacterium sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, 7 kinds of Grain-negative enteral pathogenic bacterium such as vibrio cholera all have inhibitory action. in vitro, Pericarpium Granati decoct all has antibacterial action to 4 kinds of dysentery bacteriums, but difference to some extent in degree, with to shigella effect the strongest (1:320), to Amur, bacterium flexneri takes second place (1:80), and to bacterium sonnei effect poor (1:20). the antibacterial effect of flat band method is lower than test tube method. and its antibacterial action mechanism is relevant with volume tannic acid contained by it.
Radix Pulsatillae bitter in the mouth, cold in nature; Return stomach, large intestine channel; There is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effect of removing dampness and killing parasites; Cure mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, the scrofula Radix Pulsatillae is the key medicine controlling amebic dysentery, and alone larger dose is namely effective.Commonly using into square Radix Pulsatillae Decoction, is namely principal agent with this product, coordinates Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini form, both can with having controlled amebic dysentery, also can with controlling bacillary dysentery." book on Chinese herbal medicine justice " carries it: Radix Pulsatillae mildly bitter flavor and light, the clear light weight of gas, and " herbal classic " is though the bitter temperature of meaning, so easily mad to cure mainly pyrexial malaria, and Zhong Jing and specially to control diarrhea of heat type with tenesmus, then Bi Feiwen medicine is known.Its main pyretic toxicity dysentery, can let out admittedly though say hardship, and elevate a turnable ladder taste clearing heat in QI system, and make not sag, then tenesmus all removes, really the tangible true essence of this medicine.
Bulbus Allii Macrostemonis is pungent, bitter, temperature.Return lung, stomach, large intestine channel.Regulate the flow of vital energy, the chest stuffiness relieving, activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma is heavy after letting out dysentery.Supplement to the Herbal carries it: in tune, and main chronic diarrhea is not recovered, normal evil person in large abdomen, but cooks it more.
Chinese medicine additive pharmacological toxicity is tested
Pharmacology pharmacodynamic is tested:
1, acute toxicity test
Application rabbit carries out acute toxicity testing and shows: rabbit oral administration gavage Chinese medicine preparation granule of the present invention, under 488.8g crude drug/kg dosage, after administration, rabbit occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of rabbit oral administration gavage Chinese medicine preparation granule of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Point out this medicine acute toxicity low, clinical drug safety.
2, long term toxicity test
Select rabbit, give the Chinese medicine preparation powder of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.Rabbit is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, and the dose safety of pointing out Chinese medicine preparation of the present invention to apply is higher.
3, animal local excitation test:
Skin anaphylactic test of the present invention and rabbit rectal application irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
Pharmacological experiment
In the breeding process of rabbit, diarrhoea is one of modal disease, and its onset speed is very fast, and pathogenic factor is complicated, is the Etiological causing the rabbit death of the young north to the Great Wall.Therefore, the diarrhoea of north to the Great Wall rabbit must have been prevented, accomplish early to find, early treatment.
The curative effect of Chinese medicine preparation granule of the present invention is proved by pharmacodynamics test below and clinical prerun:
One. the impact of model that rabbit caused by Oleum Ricini is had loose bowels
Get rabbit 40, male and female half and half, be divided into model control group, antibiotic (cereobiogen sheet, galactenzyme raw cook or yeast tablet group), granule high dose group of the present invention, low dose group at random.Give relative medicine 0.2ml/10gB.W. by organizing gavage respectively, model group gives equal-volume normal saline, once a day, and continuous three days.Last administration is after 40 minutes, and every animal gavage gives 0.2ml Oleum Ricini.Then the cell isolation cage of filter paper is placed with immediately below being put into by rabbit, every lattice one.Observation index: muck counts; Muck counting made by the filter paper spreading 10cm × 10cm area immediately below every cell.React with muck grain number degree of having loose bowels, first 1 ~ 6 hour replacing filter paper per hour once, changes paper once in 7 ~ 24 hours, records the accumulation muck sum of each animal in 24 hours, compares with model control group, with t inspection between SPSS software group.The results are shown in Table one.
The anti-diarrhea effect (X ± SD) of having loose bowels caused by table a pair Oleum Ricini
Note: compare with model control group, * * P < 0.01, * * * P < 0.001
From table one, medicine of the present invention can significantly suppress rabbit caused by Oleum Ricini to be had loose bowels.
Two. Small intestine advance activity is tested
Get rabbit 40, male and female half and half, be divided into Normal group, antibiotic group (cereobiogen sheet, galactenzyme raw cook or yeast tablet group), high dose group of the present invention, low dose group at random.Give relative medicine 0.2ml/10gB.W. respectively by organizing gavage respectively, Normal group gives equal-volume normal saline, once a day, and continuous four days.Each group of rabbit starts fasting 24 hours on the 3rd day upon administration.Test the 4th day, after administration 1 hour, gavage 5% Insta-Char 0.2ml/10gB.W..After 20 minutes, de-cervical vertebra puts to death animal, open abdominal cavity, be separated mesentery, to pylorus on clip, down to the intestinal tube between ileocecus, be placed on flat pallet, gently small intestinal is pulled into straight line, measure Length of intestine as " total small intestinal length ", from pylorus to the distance in prepared Chinese ink forward position as " prepared Chinese ink is at enteral advance distance ".Calculate prepared Chinese ink ink propulsive rate, with t inspection between SPSS software group.The results are shown in Table two.
Table two is on the impact (X ± SD) of Small intestine advance activity
Note: compare with Normal group, * * P < 0.01, * * * P < 0.001.
From table two, the present invention and all have obvious inhibitory action to gastrointestinal propulsive movement.
Illustrate:
Acute or the chronic disease that Escherichia coli and toxin thereof cause.Mainly betide the young rabbit of 25-70 age in days, rabbit of falling ill shows as diarrhoea or constipation, and what have is watery diarrhea, often has gel-shaped mucus in feces.When feeding and management is improper or weather drastic change time, north to the Great Wall rabbit body resistance decline, escherichia coli quantity can sharply increase, thus cause morbidity.The acute infectious disease of the digestive tract that the extracellular toxin of A type clostridieum welchii causes, its sickness rate, mortality rate are all higher.The equal susceptible of rabbit at each kind, age, wherein the young rabbit invasion rate at 1-3 monthly age is high.The diarrhoea that salmonellosis causes mainly betides young north to the Great Wall rabbit and conceived 25 days later female rabbits.
Transmissible gastroenteritis is acute infectious intestinal disease.Main manifestations is anorexia and diarrhoea, especially in cold season, can infect rapidly the rabbit at various age, and the young rabbit of 20-30 age in days serious de-water and eletrolytes often occurs and loses, and case fatality rate is higher.Young rabbit case fatality rate more than 3 monthly ages is lower.Epidemic diarrhea infectious intestinal disease, not only betides young rabbit, and also has generation at adult rabbits, and infection rate is 100%, and the M & M of the Tu Heyou north to the Great Wall, young north to the Great Wall rabbit is all higher.Clinical manifestation is row's watery stools and dehydration, and annual each Ji Junke occurs.
Diarrhoea rabbit general abdominal part expands, hypourocrinia and in canescence, gastrointestinal peristalsis strengthens, and has seasonal disease north to the Great Wall rabbit to present stomachache.Sick north to the Great Wall rabbit down in spirits, astasia is weak, body temperature raises, by hair slightly disorderly, poor appetite or absolutely useless, and there is diarrhoea, start as yellow loose stool, anaphase transition is taupe or black watery stools, have just in band blood or have open-minded film, taste is smelt as of rotten fish, most of sick north to the Great Wall rabbit hind leg, anus and afterbody are polluted by hair, anus blocking serious individually.Disease rabbit coolness of extremities, eye socket sink, and becomes thin rapidly, death in 2-3 days after general morbidity, the sustainable 5-7 days of some courses of disease.
The personnel that feed often observe, and find that disease rabbit moves to drying, warm isolation rabbit home in time, ascertain the reason, take corresponding nursing intervention, prevent from infecting.Preventive medicine is added in daily ration.
Rabbit home and place with hundred poisoning solution disappear raise apparatus every other day with 3% lysol solution thorough disinfection once, eliminate the feces in cage, house in time, duty change pad grass, keep rabbit home to clean, drying and good ventilation.
Claims (4)
1. treat the Chinese medicine preparation of rabbit diarrhoea for one kind, it is characterized in that, in described Chinese medicine preparation, the number of each crude drug is: Herba Andrographis 10 ~ 20 weight portion, Pericarpium Granati 10 ~ 20 weight portion, Herba Patriniae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, the Radix Pulsatillae 10 ~ 20 weight portion, Radix Angelicae Sinensis 10 ~ 20 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 weight portion, Bulbus Allii Macrostemonis 10 ~ 20 weight portion, Massa Medicata Fermentata (parched to brown) 10 ~ 20 weight portion, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portion, the Radix Rehmanniae 10 ~ 20 weight portion, Herba Hedyotidis Diffusae 10 ~ 20 weight portion, Herba Taraxaci 10 ~ 20 weight portion, Rhizoma Coptidis 10 ~ 20 weight portion, Cortex Fraxini 10 ~ 20 weight portion, Pericarpium Arecae 10 ~ 20 weight portion, Radix Codonopsis 10 ~ 20 weight portion, Radix Scutellariae 10 ~ 20 weight portion, Rhizoma Smilacis Glabrae 10 ~ 20 weight portion and Herba Artemisiae Annuae 10 ~ 20 weight portion.
2. treat the Chinese medicine preparation of rabbit diarrhoea according to claim 1, it is characterized in that, in described Chinese medicine preparation, the number of each crude drug is: Herba Andrographis 10 ~ 15 weight portion, Pericarpium Granati 10 ~ 15 weight portion, Herba Patriniae 10 ~ 15 weight portion, Radix Sanguisorbae 10 ~ 15 weight portion, the Radix Pulsatillae 10 ~ 15 weight portion, Radix Angelicae Sinensis 10 ~ 15 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 weight portion, Bulbus Allii Macrostemonis 10 ~ 15 weight portion, Massa Medicata Fermentata (parched to brown) 10 ~ 15 weight portion, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 weight portion, the Radix Rehmanniae 10 ~ 15 weight portion, Herba Hedyotidis Diffusae 10 ~ 20 weight portion, Herba Taraxaci 10 ~ 20 weight portion, Rhizoma Coptidis 10 ~ 20 weight portion, Cortex Fraxini 10 ~ 20 weight portion, Pericarpium Arecae 10 ~ 20 weight portion, Radix Codonopsis 10 ~ 20 weight portion, Radix Scutellariae 10 ~ 20 weight portion, Rhizoma Smilacis Glabrae 10 ~ 20 weight portion and Herba Artemisiae Annuae 10 ~ 20 weight portion.
3. treat the Chinese medicine preparation of rabbit diarrhoea according to claim 1, it is characterized in that, in described Chinese medicine preparation, the number of each crude drug is: Herba Andrographis 10 ~ 20 weight portion, Pericarpium Granati 10 ~ 20 weight portion, Herba Patriniae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, the Radix Pulsatillae 10 ~ 20 weight portion, Radix Angelicae Sinensis 10 ~ 20 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 weight portion, Bulbus Allii Macrostemonis 10 ~ 20 weight portion, Massa Medicata Fermentata (parched to brown) 10 ~ 20 weight portion, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portion, the Radix Rehmanniae 10 ~ 20 weight portion, Herba Hedyotidis Diffusae 10 ~ 15 weight portion, Herba Taraxaci 10 ~ 15 weight portion, Rhizoma Coptidis 10 ~ 15 weight portion, Cortex Fraxini 10 ~ 15 weight portion, Pericarpium Arecae 10 ~ 15 weight portion, Radix Codonopsis 10 ~ 15 weight portion, Radix Scutellariae 10 ~ 15 weight portion, Rhizoma Smilacis Glabrae 10 ~ 15 weight portion and Herba Artemisiae Annuae 10 ~ 15 weight portion.
4. according to any one of claim 1-3, treat the Chinese medicine preparation of rabbit diarrhoea, it is characterized in that, the dosage form of described Chinese medicine preparation is granule, powder, plaster or ointment.
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| CN104758417A (en) * | 2015-03-06 | 2015-07-08 | 钟云仙 | Chinese medicinal composition for treatment of chicken coccidiosis |
| CN105055504A (en) * | 2015-08-11 | 2015-11-18 | 中国农业科学院兰州畜牧与兽药研究所 | Feed additive compound essential oil for preventing diarrhea of pigeons as well as preparation method and application of essential oil |
| CN106234811A (en) * | 2016-08-04 | 2016-12-21 | 遵义县强芳养殖发展有限公司 | A kind of beaver rabbit feed |
| KR102041847B1 (en) | 2017-10-16 | 2019-11-07 | 한국 한의학 연구원 | Composition for preventing, improving or treating depression and anxiety disorders comprising Fraxinus rhynchophylla extract as effective component |
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| CN102772781A (en) * | 2012-08-21 | 2012-11-14 | 杨高林 | Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof |
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