CN103719552B - Feed for preventing and treating swine erysipelas and preparation method for feed - Google Patents

Abstract

The invention discloses a feed for preventing and treating swine erysipelas and a preparation method for the feed. The feed comprises the following raw materials of barley, wheat, composite enzyme, yam powder, methionine, threonine, vitamin premix and a traditional Chinese medicinal additive. The feed disclosed by the invention has the beneficial effects that the feed contains the traditional Chinese medicinal additive for treating the swine erysipelas, and the main therapeutic principle of the traditional Chinese medicinal additive is to clear away heat and purge pathogenic fire, nourish yin, promote the secretion of saliva or body fluid, regulate qi and blood and regulate spleen and stomach; the traditional Chinese medicinal additive and other feed raw materials are interactive and are matched, so that the feed has an outstanding preventing and treating effect on the swine erysipelas and has the advantages of low side effect, high curing rate, short treating course, less possibility of relapse and the like.

Description

Feed for preventing and treating swine erysipelas and preparation method thereof

technical field

The invention relates to a pig feed, in particular to a feed for preventing and treating swine erysipelas and a preparation method thereof.

Background technique

Erysipelas suis is an acute febrile infectious disease caused by Erysipelas suis. Its main features are high fever, acute sepsis, skin rash (subacute), chronic verrucous endocarditis, skin necrosis and multiple non-suppurative joints. Inflammation (chronic). At present, intensive pig farms are relatively rare, but they have not been completely controlled. The disease is distributed worldwide. E. suis is a Gram-positive bacterium with a marked tendency to form filaments. The bacterium is a flat or slightly curved slender bacillus with a size of 0.2-0.4 microns × 0.8-2.5 microns. Bacteria in disease materials are arranged singly, in pairs or in clumps, generally in clumps in white blood cells, and in old broth cultures and endocardial warts of chronically diseased pigs, mostly in the form of filaments , sometimes very thin. This fungus has strong resistance to natural environments such as salting, fire smoking, drying, corruption and sunlight.

In the liver and spleen of dead pigs at 4°C for 159 days, the virulence is still strong. Erysipelas suis can be isolated from dead pig livers placed in the open air for 27 days, sick pig corpses buried 1.5 meters deep for 231 days, and pork treated with 12.5% salt and refrigerated at 4°C for 148 days. It dies quickly in general disinfectants, such as 2% formalin, 1% bleach, 1% sodium hydroxide or 5% carbonic acid. The resistance to heat is weak, and the broth culture can be killed after 12 to 20 minutes at 50°C and 5 minutes at 70°C. The acid resistance of this bacteria is strong, and the acidity in the stomach of pigs cannot kill it, so it can enter the intestinal tract through the stomach.

The pathological changes of porcine erysipelas are as follows: (1) Acute type gastric fundus and pyloric perineum with diffuse hemorrhage and spot bleeding; catarrhal or hemorrhagic inflammation in the whole intestinal tract; splenomegaly, typical Septic blood spleen; kidney congestion, swelling, known as "big purple kidney"; lymph node congestion, swelling, cut surface everted, juicy, lung congestion, edema (2) subacute type The center of the congested spot can be oppressed by edema Pale in color. (3) Chronic type ① Endocarditis: In the heart, cauliflower-like growths can be seen in the mitral valve and aortic valve with defect-like endocarditis. ②Arthritis: joint swelling, with accumulation of serous and fibrinous exudate.

The main symptoms of swine erysipelas are: the incubation period of clinical symptoms is as short as 1 day and as long as 7 days. Acute type: This type is common, characterized by sudden outbreak, acute course and high mortality. Sick pigs are depressed, high fever persists; no food, vomiting; conjunctival hyperemia; feces are dry and hard with mucus. Piglets have diarrhea later. The skin on the ear, neck, and back is flushed and purplish. Before death, there were irregular bright red plaques in the armpits, thighs, and abdomen, which faded and merged together after finger pressure. Usually die within 3-4 days. The case fatality rate is about 80%, and the undead will turn into rash type or chronic type. When swine erysipelas occurs in suckling piglets and newly weaned piglets, it usually comes on suddenly, manifests neurological symptoms, convulsions, falls to the ground and dies, and the course of the disease does not exceed one day at most. Subacute type (rash type): the disease is relatively mild. In the first day or two, rashes with obvious boundaries appear on different parts of the body, especially on the chest, back, neck, and the whole body. "Fire print", finger pressure fades. The rash protrudes from the skin by 2-3 mm, the size is about one to several centimeters, ranging from a few to dozens, and brown scabs form after drying. Sick pigs are thirsty, constipated, vomited, and have high body temperature. After the rash occurred, the body temperature began to drop, and the condition of the disease was alleviated. After several days or even more than ten days, the sick pigs recovered on their own. There are also many sick pigs whose symptoms worsen and turn into septic blood during the course of the disease and die. The course of the disease is about 1-2 weeks. Chronic type: transformed from acute type or subacute type, and also primary, common types include chronic arthritis, chronic endocarditis, and skin necrosis. The chronic arthritis type mainly manifests as inflammatory swelling of limb joints (wrist and tarsal joints are more common than knee and hip joints), stiffness and pain in sick legs. Afterwards, the acute symptoms disappeared, and the joint deformation was the main one, showing one or both limbs walking or lying on the ground. Sick pigs have normal appetite, but slow growth, weak constitution and emaciation. The course of the disease is weeks or months. The chronic endocarditis type mainly manifests as emaciation, anemia, general weakness, prefers to lie down, dislikes walking, and when forced to walk, the behavior is slow and the whole body shakes. Auscultation heart murmur, rapid heartbeat, hyperactivity, arrhythmia, shortness of breath. Pigs with this disease cannot be cured, and usually die suddenly due to cardiac paralysis. Ulcerative or broccoli verrucous neoplastic endocarditis. Irregular heartbeat, trouble breathing, anemia. The course of the disease is several weeks to several months. The chronic form of swine erysipelas sometimes results in skin necrosis. It often occurs on the back, shoulders, ears, hooves and tail. The local skin is swollen, raised, necrotic, dark in color, hard and leathery. Gradually separate from the underlying new tissue, like a layer of carapace. Sometimes the necrosis area is very large and can occupy the entire back skin; sometimes necrosis can occur in part of the ear shell, tail, tip, and each hoof shell. After about 2 to 3 months, the necrotic skin fell off, leaving behind a hairless, light-colored scar that healed. If there is a secondary infection, the condition is complicated and the course of the disease is prolonged.

Currently, the drugs for the prevention and treatment of swine erysipelas are penicillins (amoxicillin) and cephalosporins (ceftiofur sodium). However, the side effects of Western medicine are relatively large, and Western medicine only has obvious curative effect on a single disease or a class of disease in the treatment. For some diseases with many diseases, the curative effect is not obvious, and often need to prescribe a lot of Western medicine, and the price is high; Many traditional Chinese medicines mainly regulate the body from the aspects of antibacterial, anti-inflammatory, heat-clearing and detoxifying, promoting blood circulation and eliminating spots when treating swine erysipelas. Compared with antibiotics, traditional Chinese medicine is not purely antibacterial. Most traditional Chinese medicines come from natural plants, and their complex components make it difficult for bacteria to develop drug resistance and cause drug residues. In recent years, the role of traditional Chinese medicine in the prevention and treatment of pullorum in piglets has attracted widespread attention.

Contents of the invention

The technical problem to be solved by the present invention is to provide a feed for preventing and treating swine erysipelas and a preparation method thereof. The feed contains traditional Chinese medicine additives for treating swine erysipelas, which has remarkable curative effect on the prevention and treatment of swine erysipelas, low side effects, and cure High rate, not easy to relapse and so on.

In order to realize the purpose of the above invention, the present invention provides a feed for preventing and treating swine erysipelas. The feed includes the following raw materials: barley, wheat, compound enzyme, yam powder, methionine, threonine, vitamin premix and traditional Chinese medicine additives.

The feed is composed of the following raw materials in parts by weight: 40-60 parts by weight of barley, 30-40 parts by weight of wheat, 5-9 parts by weight of compound enzyme, 10-20 parts by weight of yam powder, 2-4 parts by weight of methionine, 2-4 parts by weight of amino acid, 4-6 parts by weight of vitamin premix and 4-9 parts by weight of traditional Chinese medicine additives.

The feed consists of the following raw materials in parts by weight: 56 parts by weight of barley, 33 parts by weight of wheat, 7 parts by weight of compound enzyme, 15 parts by weight of yam powder, 3 parts by weight of methionine, 3 parts by weight of threonine, vitamin premix 5 parts by weight and 6 parts by weight of traditional Chinese medicine additives.

The compound enzyme is composed of dextranase, vitaminase and amylase; the main components of the vitamin premix are: vitamin A, vitamin D ₃ , vitamin E, vitamin K ₃ , vitamin B ₁ , vitamin B ₂ , vitamin B _6. Vitamin B ₁₂ , folic acid, biotin, niacin, pantothenic acid, cottonseed protein, corn starch, antioxidants and probiotics;

The traditional Chinese medicine additive is composed of the following raw materials: honeysuckle, hemp curd, wild jujube, trichosanthes pollen, garlic, potato, ant, dalun wood, rhubarb, glutinous rice, talc, shegan, mountain bean root, Daqingye, Tinglizi, Paeonol, Rehmannia glutinosa, Scrophulariaceae, Licorice, Almonds, Diding, Catkins, Duckweed, Alum and Dandelion.

The traditional Chinese medicine additive is composed of the following raw materials in parts by weight: 10-20 parts by weight of honeysuckle, 18-28 parts by weight of hemp tofu, 10-26 parts by weight of southern jujube, 10-20 parts by weight of trichosanthes, and 10-20 parts by weight of garlic , 10-15 parts by weight of potatoes, 10-20 parts by weight of ants, 10-26 parts by weight of Dalun wood, 10-20 parts by weight of rhubarb, 10-15 parts by weight of glutinous rice, 10-26 parts by weight of talc, 10-25 parts by weight of shegan 10-15 parts by weight of mountain bean root, 10-20 parts by weight of Daqingye, 10-20 parts by weight of Tinglizi, 10-24 parts by weight of paeonol, 10-26 parts by weight of rehmannia, 10-20 parts by weight of Scrophulariaceae parts by weight, 10-24 parts by weight of licorice, 10-24 parts by weight of almonds, 10-20 parts by weight of catkins, 10-20 parts by weight of catkins, 10-15 parts by weight of duckweed, 10-15 parts by weight of alum and 10-20 parts by weight of dandelion 20 parts by weight.

The traditional Chinese medicine additive is composed of the following raw materials in parts by weight: 12-17 parts by weight of honeysuckle, 19-25 parts by weight of hemp tofu, 14-22 parts by weight of southern jujube, 13-18 parts by weight of trichosanthes, and 12-17 parts by weight of garlic 10-15 parts by weight of potatoes, 15-20 parts by weight of ants, 15-26 parts by weight of Dalun wood, 10-15 parts by weight of rhubarb, 10-15 parts by weight of glutinous rice, 10-18 parts by weight of talc, and 10-21 parts by weight of shegan 10-15 parts by weight of mountain bean root, 10-17 parts by weight of Daqingye, 10-16 parts by weight of Tinglizi, 12-20 parts by weight of paeonol, 13-18 parts by weight of Rehmannia glutinosa, 13-18 parts by weight of Scrophulariaceae Parts by weight, 13-21 parts by weight of licorice, 15-21 parts by weight of almonds, 12-17 parts by weight of catkins, 12-18 parts by weight of catkins, 13-15 parts by weight of duckweed, 13-15 parts by weight of alum and 13-15 parts by weight of dandelion 17 parts by weight.

The traditional Chinese medicine additive is composed of the following raw materials in parts by weight: 15 parts by weight of honeysuckle, 23 parts by weight of hemp tofu, 18 parts by weight of southern jujube, 15 parts by weight of trichosanthin, 15 parts by weight of garlic, 13 parts by weight of potatoes, and 17 parts by weight of ants , 21 parts by weight of Dalun wood, 13 parts by weight of rhubarb, 13 parts by weight of glutinous rice, 14 parts by weight of talc, 15 parts by weight of dry root, 12 parts by weight of mountain bean root, 15 parts by weight of Daqingye, 13 parts by weight of Tinglizi, dandelion 16 parts by weight of skin, 15 parts by weight of raw rehmannia, 16 parts by weight of Scrophulariaceae, 17 parts by weight of licorice, 18 parts by weight of almonds, 15 parts by weight of dichotoma, 15 parts by weight of catkins, 14 parts by weight of duckweed, 14 parts by weight of alum and dandelion 15 parts by weight.

The traditional Chinese medicine additive also includes the following raw materials: tangerine peel, disha, clove and hawthorn.

The traditional Chinese medicine additive is composed of the following raw materials: 12-17 parts by weight of honeysuckle, 19-25 parts by weight of hemp tofu, 14-22 parts by weight of southern jujube, 13-18 parts by weight of trichosanthin, 12-17 parts by weight of garlic, 10-25 parts by weight of potato 15 parts by weight, 15-20 parts by weight of ants, 15-26 parts by weight of Dalun wood, 10-15 parts by weight of rhubarb, 10-15 parts by weight of glutinous rice, 10-18 parts by weight of talc, 10-21 parts by weight of shegan, mountain beans 10-15 parts by weight of root, 10-17 parts by weight of Daqing leaf, 10-16 parts by weight of Tinglizi, 12-20 parts by weight of paeonol, 13-18 parts by weight of rehmannia glutinosa, 13-18 parts by weight of Scrophulariaceae, licorice 13 to 21 parts by weight, 15 to 21 parts by weight of almonds, 12 to 17 parts by weight of catkins, 12 to 18 parts by weight of catkins, 13 to 15 parts by weight of duckweed, 13 to 15 parts by weight of alum, 13 to 17 parts by weight of dandelion, 10-15 parts by weight of orange peel, 10-20 parts by weight of ground sand, 10-20 parts by weight of clove and 10-20 parts by weight of hawthorn.

The traditional Chinese medicine additive is composed of the following raw materials: 15 parts by weight of honeysuckle, 23 parts by weight of hemp curd, 18 parts by weight of southern jujube, 15 parts by weight of trichosanthin, 15 parts by weight of garlic, 13 parts by weight of potato, 17 parts by weight of ants, 21 parts by weight, 13 parts by weight of rhubarb, 13 parts by weight of glutinous rice, 14 parts by weight of talc, 15 parts by weight of dry root, 12 parts by weight of mountain bean root, 15 parts by weight of Daqingye, 13 parts by weight of Tinglizi, 16 parts by weight of paeonol , 15 parts by weight of rehmannia glutinosa, 16 parts by weight of Scrophulariaceae, 17 parts by weight of licorice, 18 parts by weight of almonds, 15 parts by weight of dichotoma, 15 parts by weight of catkins, 14 parts by weight of duckweed, 14 parts by weight of alum, 15 parts by weight of dandelion, 13 parts by weight of tangerine peel, 15 parts by weight of ground sand, 15 parts by weight of clove and 15 parts by weight of hawthorn.

The preparation method of described Chinese medicine additive comprises the following steps:

The first step is to mix all the raw materials in proportion, crush them into powder, put them into a multifunctional extraction tank, add ethanol with an alcohol concentration of 80% to 90% relative to the mass of the mixture, and heat to reflux for 1 hour to Extract for 3 hours to obtain the extract, the vapor pressure during the heating and reflux process is 0.4MPa-0.6MPa, filter the extract to obtain the first filtrate and filter residue;

In the second step, add the filter residue obtained in the first step to ethanol with an alcohol concentration of 80% to 90% relative to the mass of the mixture in the first step, and heat and reflux for 0.5 to 1.5 hours to obtain an extract, and heat to reflux The steam pressure in the process is 0.4MPa～0.6MPa, and the extract is filtered to obtain the second filtrate;

The third step is to combine the first filtrate and the second filtrate, concentrate under reduced pressure to remove the solvent, and obtain a dry paste, put the dry paste into a spray dryer to dry, and ensure that the air inlet temperature is 170°C to 190°C, and the air outlet The temperature is 60° C. to 80° C., and then crushed into 200 mesh to 400 mesh to obtain traditional Chinese medicine additive powder.

In order to better realize the above-mentioned invention object, the present invention provides a kind of preparation method of the feedstuff that is used for preventing and treating porcine erysipelas, and described preparation method comprises the following steps:

(1) Crushing step: weighing barley and wheat by weight percentage and putting them into a pulverizer for fine pulverization, passing through a 2.0mm sieve after pulverization;

(2) Ingredients step: mix yam powder, methionine, threonine, vitamin premix and traditional Chinese medicine additives according to the weight ratio, put into the mixer, mix evenly, and the mixing time is 20-30s;

(3) Granulation step: put it into a granulator for granulation, and the granulation temperature is 70°C to make the gelatinization degree reach more than 90%;

(4) Classification step: crushing, sieving and classification after granulation;

(5) Spraying step: spray the compound enzyme onto the surface of the crushed pellet feed.

The beneficial effects brought by the technical solutions provided by the embodiments of the present invention are: the feedstuff of the present invention contains traditional Chinese medicine additives for treating swine erysipelas. Working together with other feed materials, it has the advantages of significant curative effect on the prevention and treatment of swine erysipelas, low side effects, high cure rate, short course of treatment, and not easy to relapse.

Detailed ways

Traditional Chinese medicine is mainly used to treat porcine erysipelas through antibacterial, improving immunity, enhancing disease resistance, anti-inflammation, reducing symptoms, maintaining the balance of gastrointestinal flora, inhibiting gastrointestinal motility, and improving the physical and chemical indicators of the body's blood. According to the theory of traditional Chinese veterinary medicine, the pathogenesis of swine erysipelas is related to many factors, such as weak pigs, climate change, and dietary problems. Traditional Chinese veterinary medicine discusses it from deficiency of Qi and blood heat. Deficiency of nutrient Qi cannot promote blood flow, so blood heat overflows meridians and blood spots appear, or body fluid is depleted due to heat damage. Liu Wansu, a doctor in the Jin Dynasty, believed that: The water is dirty, the deficiency is hot, and the reality is cold. The heart is the organ of fire, which is restricted by the kidney water, so it is advocated the treatment principle of nourishing the kidney water to relieve the heart fire. Nourishing kidney water is the root cause, and purging heart-fire is a temporary solution. "Suwen·Xuanji Yuanbing Formula": "Reducing the excess and tonifying the deficiency, it's nothing more than calming down." Pig erysipelas mainly uses heat-clearing and purging medicines, and more importantly, re-uses Yin-nourishing and fluid-promoting medicines. When qi and blood are blocked, all diseases are born, and if it is blocked, it will cause pain. When swine erysipelas, the ying qi is weak and cannot promote the blood flow, and the hot blood flows outside the meridians in vain, so bleeding macules occur. Therefore, swine erysipelas treats qi and blood, eliminates spots and eruptions. By promoting the circulation of qi and blood, the various nutrients in the body are gradually allocated to the optimal configuration in the body. The spleen is the foundation of acquired constitution, the spleen is the mother of the viscera, the spleen and stomach are like the roots of a tree, without the biochemical function of the spleen, the viscera lose nutrition, life cannot exist, the stomach is the sea of grains, without the function of the stomach, the spleen cannot perform biochemical transportation Therefore, we must also pay attention to regulating the spleen and stomach.

Based on the above principles, the present invention takes clearing heat and purging fire, nourishing yin and promoting body fluid, regulating qi and blood, and regulating spleen and stomach as the main treatment principles, and provides a feed containing traditional Chinese medicine additives for preventing and treating swine erysipelas. , hemp tofu, southern jujube, trichosanthes, garlic, potato, ant, dalun wood, rhubarb, glutinous rice, talc, shegan, mountain bean root, big green leaf, Tinglizi, paeonol, rehmannia, scrophulariaceae, licorice, Almonds, catkins, catkins, duckweed, alum and dandelions.

In the prescription, the pharmacology of each crude drug is as follows:

Honeysuckle: sweet in taste, cold in nature, enters the heart, lung, stomach, and large intestine meridian, has the effect of clearing away heat and detoxifying, and can also cool blood and stop dysentery. When the pathogenic heat is still in the upper burnt but not descending; dysentery and blood in the stool due to heat toxicity; heat-heat syndrome; early onset of sores and carbuncles due to accumulation of heat and toxins, heat swelling and pain, and other skin infections, this product has a good curative effect. It has antipyretic effect, anti-inflammatory effect, can promote the phagocytosis of white blood cells, and has strong antibacterial effect on various pyogenic cocci and intestinal pathogenic bacteria.

Mafu: benefit the stomach, relieve heat and poison, nourish the essence, most beneficial to the elderly. Moisturizes muscles, smooths intestines, detoxifies.

Southern Suanzao: sweet in taste; sour; flat in nature. Return spleen; Liver channel. Functions and indications: promoting qi and blood circulation; nourishing the heart and calming the nerves; eliminating stagnation; detoxification. Main Qi stagnation and blood stasis; chest pain; palpitations and shortness of breath; neurasthenia; insomnia; bronchitis; food stagnation and fullness in the abdomen; diarrhea; hernia;

Radix Trichosanthis: sweet, slightly bitter, slightly cold. Return lung, stomach warp. Clearing away heat and promoting body fluid, detumescence and drainage of pus. For fever and polydipsia, dry cough due to lung heat, internal heat and thirst, sore and swollen toxin. "Compendium": Trichosanthes chinensis root, tastes sweet and slightly bitter, acid can produce body fluid, so it can quench thirst and moisten dryness, slightly bitter and reduce fire, sweet and not hurt the stomach, the ancients only said that it is bitter and cold, it seems that it has not been deeply understood. "Compendium of Materia Medica": Trichosanthum, relieves stagnation and heat in the five internal organs, such as excessive heart fire and dry tongue and mouth, excessive lung fire and swollen throat and throat, excessive spleen fire and swollen mouth, tongue and teeth, excessive phlegm fire and restless cough. If the liver-fire is distended and drained, the bones of the kidney-fire are steaming and hot, or the carbuncle is ulcerated but the heat toxin persists, or the five jaundice, the body and the eyes are yellow, and the small water is dripping or astringent, it is all caused by the stagnation of fire and heat. Cause, only this agent can open stagnation, reduce phlegm fire, and can cure it. In addition, its nature is sweet and cold, and it is good at curing thirst. It can be used to cure deficiency and thirst from tonic, to cure fire thirst from cold medicine, to cure thirst from qi medicine, and to cure polydipsia from blood medicine, which is the key medicine for thirst.

Garlic: warm in nature, pungent in taste; enters the spleen, stomach, and lung meridians. Detoxification and killing insects, reducing swelling and pain, stopping diarrhea and dysentery, curing lungs, repelling insects, and warming the spleen and stomach. Treatment of carbuncle and swollen poison, white baldness and ringworm, dysentery and diarrhea, tuberculosis, cough, roundworm pinworms, food stagnation, cold pain in the abdomen, edema and fullness, promoting qi and eliminating accumulation, killing insects and detoxifying. For colds, bacillary dysentery, amoebic dysentery, enteritis, dietary stagnation, carbuncle sores. Powerful sterilization: The sulfur compounds in garlic have extremely strong antibacterial and anti-inflammatory effects, and can inhibit and kill a variety of cocci, bacilli, fungi and viruses. It is the strongest antibacterial effect found in natural plants. Prevention and treatment of tumors and cancer: elements such as germanium and selenium in garlic can inhibit the growth of tumor cells and cancer cells. Experiments have found that the population with the lowest incidence of cancer is the population with the highest selenium content in the blood. The National Cancer Institute of the United States believes that among the plants with the most anti-cancer potential in the world, garlic ranks first. Detoxification and intestinal cleansing, prevention of gastrointestinal diseases: Garlic can effectively inhibit and kill bacteria and viruses such as Helicobacter pylori that cause gastrointestinal diseases, remove toxic substances in the stomach, stimulate the gastrointestinal mucosa, promote appetite, and accelerate digestion. Lower blood sugar and prevent diabetes: garlic can promote the secretion of insulin, increase the absorption of glucose by tissue cells, improve the glucose tolerance of the human body, quickly reduce the blood sugar level in the body, and kill various bacteria that induce diabetes due to infection, so as to effectively prevent and treat it diabetes. Prevention and treatment of cardiovascular and cerebrovascular diseases: Garlic can prevent fat deposition in cardiovascular and cerebrovascular, induce fat metabolism in tissues, significantly increase fibrinolytic activity, lower cholesterol, inhibit platelet aggregation, reduce plasma concentration, increase arteriolar expansion, promote Vasodilation, regulating blood pressure, increasing the permeability of blood vessels, thereby inhibiting the formation of thrombus and preventing arteriosclerosis. Eating 2-3 cloves of garlic every day is the best and easiest way to lower blood pressure. Garlic can help maintain an appropriate amount of an enzyme in the body and avoid high blood pressure.

Potato: sweet in taste; mild in nature. Functions and indications: harmonize the stomach and invigorate the middle; detoxify and reduce swelling. Main stomach pain; ribs; carbuncle; eczema; scald.

Ant: salty in taste; sour; flat in nature. Return liver; Kidney channel. Functions and indications: tonifying kidney and replenishing essence; dredging channels and activating collaterals; detoxifying and reducing swelling. Mainly used for kidney deficiency dizziness and tinnitus; insomnia and dreaminess; impotence and nocturnal emission; rheumatic arthralgia; stroke hemiplegia6; numbness of hands and feet; lupus erythematosus; scleroderma;

Dalunmu: sour; pungent; slightly bitter; slightly warm. Function cures mainly: expelling wind and reducing swelling; dissipating blood stasis to relieve pain. Main bruises; rheumatism ostalgia; gastrointestinal colic; cellulitis; abscess; stomatitis.

Rhubarb: Indications for excess heat and constipation; heat knot in the chest; damp-heat diarrhea; jaundice; gonorrhea; edema and abdominal fullness; dysuria; red eyes; sore throat; mouth sores; stomach heat vomiting; vomiting blood; hemoptysis; epistaxis; ; hematuria; blood accumulation; amenorrhea; postpartum stasis abdominal pain; abdominal mass accumulation; bruises; pyretic carbuncle ulcer; erysipelas; scald.

Glutinous rice: sweet, warm. Cure mainly to invigorate the middle and replenish qi, control thirst, profuse urination, spontaneous sweating, and diarrhea. It is used for spleen deficiency, lack of food, fatigue and loose stools, and women are dirty and irritable. Immunosuppressive effect: The alcohol extract of jujube was administered to rats at 100 mg per day, showing that jujube and azathioprine have the same immunosuppressive effect, and can inhibit the production of antibodies for atopic diseases. Jujube alcohol extract may have inhibitory effect on reactive antibodies in rats, but not on non-reactive antibodies. The flavonoid diglucoside A in jujube has been proved by pharmacological experiments to have sedative, hypnotic and antihypertensive effects, and jujube has the effect of increasing cAMP in white blood cells. Jujube decoction can reduce the damage of CCl4 to the liver.

Talc: sweet, light, cold. Return bladder, lung, stomach warp. Function cures mainly: inducing diuresis to treat stranguria syndrome, clearing away heat and relieving summer-heat, dispelling dampness and astringing sores. For hot stranguria, stone stranguria, hot and painful urination, summer-dampness polydipsia, damp and hot water diarrhea; external treatment of eczema, eczema, prickly heat.

Shegan: bitter in taste, cold in nature, returns to the lung and liver meridian, has the effect of clearing heat and detoxification, clearing phlegm and relieving throat, used for symptoms such as stagnation of heat, phlegm and fire, sore throat, phlegm and saliva, cough and asthma, etc. For the treatment of respiratory diseases, it is often used as the main drug in the compound antiviral respiratory diseases. Isoflavones and triterpenoids in Shegan are the main antiviral components. At present, more than 30 kinds of isoflavones have been reported in Shegan. Isoflavones have anti-inflammatory, free radical scavenging, anti-bacterial, anti-viral and anti-oxidant effects on the occurrence and development of pneumonia, reduce inflammation, and have a delayed effect on cell lesions caused by herpes virus Ⅰ. According to relevant reports, the triterpene saponins in Shegan can enhance the body's cellular immunity, promote the production of antibodies and complements, and regulate cytokines.

Shandougen: bitter, cold; poisonous. Return lung, stomach warp. Functions and indications: heat-clearing and toxic substances removing, reducing swelling and relieving sore throat. For accumulation of fire and poison, sore throat, gingival swelling and pain.

Folium Folium: It is mainly used for hot spots, erysipelas, sore throat, sore mouth and tongue, sore carbuncle and swollen toxin. In recent years, this medicine has been widely used clinically. In addition to treating the above-mentioned diseases, it can also be used for phlegm-heat stagnation in the lungs and thick yellow phlegm. It is especially commonly used for epidemic encephalitis B. It can be used alone for prevention and It can be combined with Bupleurum, Yinhua, Forsythia, Radix Isatidis, Scrophulariaceae, Rehmannia, etc. It can clear away the heat and poison of qi and nutrient, and can be used to treat various types of Japanese encephalitis, and the partial heat type is more suitable. "Compendium": "Main heat and toxic dysentery, jaundice, sore throat, erysipelas." "Blue leaf juice, solution of mylabris, coriander green, jaundice chicken, cinnabar, arsenic stone poison." , macular rash due to wind-heat, carbuncle sores, swelling and pain, relieve polydipsia, stop epistaxis, hematemesis, kill malnutrition, gold sore curare poison. For those who are both heat and poison, it is suitable to use blue leaf juice."

Tinglizi: pungent; bitter; cold. Return lung meridian; Heart meridian; Liver meridian; Stomach meridian; Bladder meridian. Function: clearing lung and lowering qi; dispelling phlegm and relieving asthma; inducing water to reduce swelling; letting out evil spirits. Indications: asthma, cough and excessive phlegm caused by saliva obstructing the lung; lung abscess; edema; hydrothorax and abdomen; dysuria; chronic cor pulmonale; asthma and swelling due to heart failure; scrofula and tuberculosis.

Cortex paeonol: "Compendium of Materia Medica": "Nourishing yin and reducing fire, detoxifying spots, benefiting the throat, clearing urine and blood stagnation. Later generations use yellow tiller to treat phase fire, but they don't know that the merit of paeonol is better. The red flower is beneficial, White flowers are tonic, and people are rarely aware of them, so they should be separated." Modern research shows that the contained paeonol and other glycoside components have anti-inflammatory effects; the methanol extract of Moutan cortex has the effect of inhibiting platelets; paeonol has sedative, Cooling, antipyretic, analgesic, antispasmodic and other central inhibitory effects and anti-atherosclerosis, diuretic, anti-ulcer effects.

Rehmannia glutinosa: It has anti-inflammatory and anti-allergic effects. Oral administration of rehmannia decoction has a significant antagonism effect on formaldehyde-induced arthritis and egg white arthritis in rats, and can inhibit the granuloma caused by subcutaneous injection of turpentine oil and the increase of capillary permeability caused by histamine. Rehmannia glutinosa water extract has obvious inhibitory effect on the increase of vascular permeability caused by histamine and mouse peritonitis caused by acetic acid, and also has anti-inflammatory effect on acute inflammation caused by egg white, while the alcohol and ether extract of rehmannia glutinosa has no anti-inflammatory effect . It has anti-fungal effect, and the rehmannia infusion has inhibitory effect on the growth of various fungi such as Trichophyton mentagrophytes, Microsporum gypsum-like Trichophyton, Microspore Trichophyton lanoides and Microspore Trichophyton audouin. It can resist the inhibitory effect of dexamethasone on the pituitary-adrenal cortex system, and can promote the synthesis of adrenal cortex hormones.

Scrophulariaceae: has antibacterial effect. In test tube, Scrophulariaceae has inhibitory effect on Trichophyton mentagrophytes, Epidermophyton flocculum and Microsporum lanoides. Scrophulariaceae infusion (1:3) also has inhibitory effect on Microsporum audouin in test tube. Experiments have shown that the antibacterial effect of Scrophulariaceae leaves is stronger than that of roots, especially for Staphylococcus aureus.

Licorice root: calm in nature, sweet in taste, belongs to the twelve meridians. Invigorating the spleen and replenishing qi, clearing away heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines. It is used for weakness of the spleen and stomach, fatigue, shortness of breath, palpitation, cough with excessive phlegm, abdominal pain, acute pain in the limbs, carbuncle and sore, relieve drug toxicity, strong detoxification, expectorant, pain relief, antispasmodic and even anticancer pharmacological effects. Licorice has the functions of lowering blood fat and anti-oxidation.

Almonds: Bitter, lukewarm. Relieving cough and relieving asthma, moistening intestines and laxative. Antitussive and antiasthmatic effects, used for cough and asthma. This product mainly enters the lung meridian. Bitterness can be reduced, and it also has the property of dredging, benefiting and opening up, and the function of descending lung qi has the function of promoting lungs to relieve cough and relieve asthma. It is an important medicine for treating cough and asthma. Compatibility with the syndrome can be used for a variety of cough and asthma syndromes. Such as wind-cold cough and asthma, combined with ephedra and licorice to dispel wind-cold, clear the lungs and relieve asthma, that is Sanao Decoction. Wind-heat cough, compatible with mulberry leaves and chrysanthemums, to disperse wind-heat, clear the lungs and relieve cough, such as Sangju drink. Dry-heat cough, compatible with mulberry leaves, fritillaria, and sand ginseng, to clear the lungs, moisten dryness and relieve cough, such as Sangxing Decoction. For cough and asthma due to lung heat, it can be combined with gypsum to clear the lungs and expel heat, clear the lungs and relieve asthma, such as Maxing Shigan Decoction. The effect on the digestive system, almonds are bitter and suffocating, and are rich in fatty oils. Fatty oil can improve the lubricating effect of intestinal contents on the mucous membrane, so almonds have the function of laxative. Anti-inflammatory and analgesic effects, the benzaldehyde produced by the decomposition of amygdalin is condensed by benzoin to generate benzoin. Benzoin has an analgesic effect, so some people in China use bitter almonds to treat advanced liver cancer, which can relieve the pain of patients, and some even do not need to take painkillers. Anti-tumor effect, the research on the anti-tumor mechanism of almonds mainly includes the following aspects: ① Some scholars believe that cancer cells contain a large amount of β-glucosidase, which can hydrolyze amygdalin to produce hydrocyanic acid (HCN), benzaldehyde and glucose. Because cancer cells lack thionitrile generating enzyme, this enzyme has a detoxification effect on HCN, turning HCN into non-toxic thionitrile compound, while normal cells lack β-glucosidase and contain a large amount of thionitrile generating enzyme. According to this theory, amygdalin should be able to selectively kill cancer cells while doing little to no harm to normal cells. ②Amygdalin can help trypsin in the body digest the hyaline-like mucin membrane of cancer cells, making white blood cells in the body more accessible to cancer cells and swallowing cancer cells. ③ It was found that amygdalin, similar to NaSCN and NaOCN, can affect the entry of thymidine into the DNA of liver tumor cells and the absorption of phosphate and amino acids by tumor cells. Hypoglycemic effect, amygdalin has the effect of preventing and treating diabetes caused by the antineoplastic drug alloxan. The hyperglycemia method induced by alloxan was used to prove that the blood sugar was measured after intraperitoneal injection of 3g/kg amygdalin for 48 hours. Concentration of amygdalin. Blood lipid-lowering effect, clinical reports, almonds can significantly reduce blood lipid levels in patients with hyperlipidemia, Spiller (1990) believed that monounsaturated fatty acids in almonds can help reduce patients with mildly elevated blood lipids, and there is no need to strictly restrict diet. Cosmetic effect, according to the theory of lung and fur, some skin diseases can be treated clinically by Xuanfei method, and it is often effective when it is compatible with eating almonds. Modern studies have proved that the fatty oil contained in bitter almonds can soften the cuticle of the skin, thereby achieving the effect of beauty. It is used for intestinal dryness and constipation. This product contains oil and is moist in texture, bitter in taste and lowers qi, so it can moisten the intestines and relieve constipation. It is often used in combination with Bai Ziren, Yu Liren, etc., such as Wuren Pill in "Shi Yi De Xiao Fang".

Diding: bitter, cold. Enter the heart, Liver Channel. Functions and indications: clearing away heat and dampness, detoxifying and reducing swelling. Treat boils, carbuncles, scrofula, jaundice, dysentery, diarrhea, red eyes, sore throat, poisonous snake bites.

Catkins: bitter; cool in nature. Function cures mainly: cooling blood for hemostasis; detoxifying and eliminating carbuncle. Main hematemesis; trauma hemorrhage; carbuncle; malignant sore.

Duckweed: pungent, cold. Return lung meridian. Functions and indications: dispelling wind-heat, promoting rash, diuresis. For impermeable measles, rubella itching, edema and oliguria.

Alum: sour in nature and flavor, cold, poisonous. Therefore, it has antibacterial and astringent effects, and can be used as a traditional Chinese medicine. Alum, also known as alum, is a refined product of alum stone. Alum is cold in nature, sour and astringent, and has a strong astringent effect. Traditional Chinese medicine believes that alum has the effects of detoxifying and killing insects, drying dampness and itching, stopping bleeding and diarrhea, clearing away heat and eliminating phlegm. Studies in recent years have confirmed that alum also has antibacterial and anti-trichomonas vaginalis effects. Antibacterial effect Alum has inhibitory effect on a variety of Gram-negative and positive cocci and bacilli; it has strong antibacterial effect on common suppurative bacteria. Experiments show that alum has inhibitory effect on Staphylococcus aureus and Proteus (test tube method). It has inhibitory effect on Escherichia coli, Pseudomonas aeruginosa, Bacillus anthracis, Freund and Shigella, typhoid bacillus and A. paratyphi, Proteus and staphylococcus, etc. (paper plate, plate method); Streptococcus, pneumococcus, and diphtheria have the strongest effects, followed by Brucella bovis, pertussis, and meningococcus, and have no effect on influenza bacilli (disc method). High-concentration alum solution also has inhibitory effect on human type (H37RV) and bovine type Mycobacterium tuberculosis. Clinically, 0.75% dried alum suspension is effective in controlling Pseudomonas aeruginosa infection in burn wounds.

Dandelion: It has the effect of resisting pathogenic microorganisms. Dandelion injection has a strong bactericidal effect on Staphylococcus aureus drug-resistant strains and hemolytic streptococcus in test tubes. bacillus, Proteus, Shigella, typhoid bacillus, etc. and catarrhal coccus also have a certain bactericidal effect. Dandelion extract (1:400) can inhibit Mycobacterium tuberculosis in test tube. Dandelion water decoction (1:80) can delay the cytopathic changes of ECHO11 virus. Dandelion alcohol extract 31mg/kg can kill Leptospira. The water infusion has inhibitory effect on various skin fungi. The decoction was given orally to rats, absorbed well, and the urine can maintain a certain antibacterial effect. It also has the functions of protecting the liver and benefiting the gallbladder. It can significantly inhibit the increase of alanine aminotransferase caused by carbon tetrachloride by gavage with dandelion decoction or injection with dandelion injection; it can significantly alleviate carbon tetrachloride-induced liver injury induced histological changes. There are reports that dandelion has a choleretic effect on animals. Gastric administration of dandelion liquid can shrink the gallbladder, relax the sphincter of Oddi, and facilitate the discharge of bile into the intestine. It is clinically effective for chronic gallbladder spasm and calculus. It also has immune function. Dandelion decoction can significantly increase the transformation rate of peripheral blood lymphocyte blasts in vitro, and dandelion polysaccharide can significantly enhance the intensity of delayed hypersensitivity of mouse foot pads caused by Ehrlich carcinoma and MM46 tumor cell antigens, and has The longer the administration time, the more effective it is, that is, the administration on the 11th to 20th day or the administration on the 2nd to 20th day after antigen stimulation has a significant effect. Intraperitoneal injection of dandelion polysaccharide can significantly enhance the cytotoxicity of antibody-dependent macrophages in mice.

The traditional Chinese medicine additive of the present invention also includes: tangerine peel, disha, clove and hawthorn.

Tangerine peel: warm in nature, pungent in taste, bitter; returns spleen, lung meridian, used for diseases such as fullness of chest and abdomen. Tangerine peel is pungent and warming, has a fragrant smell, is good at regulating qi, and can enter the spleen and lungs, so it can not only dissipate lung qi, but also promote qi expansion. It is used for stagnation of lung qi, fullness of chest and diaphragm, and stagnation of spleen and stomach qi , Distension and fullness in the abdomen, etc. It is used for diseases such as dampness resistance and middle burner, abdominal distension, loose stools and diarrhea, and cough with excessive phlegm. Tangerine peel is bitter, warms and dries dampness and can invigorate the spleen and promote qi, so it is often used for dampness resistance in the middle of the burn, abdominal distension, loose stools and greasy moss, and can be used together with Atractylodes atractylodes and Magnolia officinalis. It is also good at drying dampness and resolving phlegm. It is a commonly used essential medicine for treating dampness and phlegm obstructing the lungs, and cough with excessive phlegm. It is used for spleen deficiency, decreased diet, indigestion, and nausea and vomiting. This product dries dampness and strengthens the spleen and appetizers. It is suitable for weak spleen and stomach, reduced diet, indigestion, and diarrhea. It is often used in conjunction with ginseng, Atractylodes macrocephala, and Poria. Because it can not only invigorate the spleen, but also regulate qi, it is often used as an adjunct to qi invigorating medicine, which can nourish but not stagnate, and prevent congestion and bloating. And drop, nausea and vomiting.

Disha: mild in nature, sweet in taste. Functions and indications: invigorating the spleen, nourishing the lungs.

Cloves: Warming the middle-medium, warming the kidneys, reducing adverse effects. Indications: Hiccup, vomiting, nausea, dysentery, cold pain in trusted subordinates, obsession, hernia, ringworm. Meridian distribution of property and flavor: pungent, warm. "Kaibao Materia Medica": "pungent in taste, warm, non-toxic." Enter the stomach, spleen and kidney channels. "Nihuazi Materia Medica": cures bad breath, nausea, treats kidney qi, rushes porpoise qi, yin pain, aphrodisiac, warms waist and knees, kills alcohol poisoning, eliminates addiction, and removes cold and fatigue.

Hawthorn: Sliced and dried, put it in a pot and stir-fry until the outside is burnt brown and the inside is yellowish brown, sprayed with water, taken out and dried in the sun, it is burnt hawthorn. It has the effects of appetizing and eliminating food, dispelling stagnation and stagnation, promoting blood circulation and dissipating blood stasis, resolving phlegm and promoting qi. The main ingredients include chlorogenic acid, caffeic acid, maslinic acid, oleanolic acid, quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin, etc. Taking hawthorn orally can increase digestive enzymes, promote fat decomposition and digestion, and is particularly effective for those who eat meat or eat too much greasy food, such as abdominal fullness, belching, lack of appetite, abdominal pain, and diarrhea. In addition, modern drug experiments have shown that hawthorn has a slow and long-lasting effect of lowering blood pressure, can also lower cholesterol and triglycerides, prevent atherosclerosis, and can also relax coronary arteries, increase myocardial contractility, and fight arrhythmia. Therefore, it is beneficial to prevent and treat hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.

Example 1 Feed 1

The embodiment of the present invention provides a kind of feed that is used for treating swine erysipelas, and feed is made up of the raw material of following parts by weight: 48 parts by weight of barley, 40 parts by weight of wheat, 9 parts by weight of compound enzyme, 13 parts by weight of yam powder, 4 parts by weight of methionine parts by weight, 4 parts by weight of threonine, 5 parts by weight of vitamin premix and 9 parts by weight of traditional Chinese medicine additives.

Among them, the compound enzyme is composed of dextranase, vitaminase and amylase with a weight ratio of 1:1:1; the main components of the vitamin premix are: vitamin A 1800IU/kg, vitamin D ₃ 270 IU/kg, Vitamin E89 IU/kg, vitamin K ₃ 0.5mg/kg, vitamin B ₁ 2.8mg/kg, vitamin B ₂ 4mg/kg, vitamin B ₆ 2mg/kg, vitamin B ₁₂ 21μg/kg, folic acid 0.6mg/kg, biological 0.4mg/kg of niacin, 29mg/kg of niacin, 21mg/kg of pantothenic acid, 8mg/kg of cottonseed protein, 11mg/kg of corn starch, 2mg/kg of antioxidant and 5mg/kg of probiotics; Composition of raw materials: 15 parts by weight of honeysuckle, 23 parts by weight of hemp curd, 18 parts by weight of southern jujube, 15 parts by weight of trichosanthin, 15 parts by weight of garlic, 13 parts by weight of potato, 17 parts by weight of ants, 21 parts by weight of Dalun wood, 13 parts by weight of rhubarb Parts by weight, 13 parts by weight of glutinous rice, 14 parts by weight of talc, 15 parts by weight of shegan, 12 parts by weight of mountain bean root, 15 parts by weight of Daqingye, 13 parts by weight of Tinglizi, 16 parts by weight of paeonol, 15 parts by weight of Rehmannia glutinosa 16 parts by weight of Scrophulariaceae, 17 parts by weight of Radix Glycyrrhizae, 18 parts by weight of almonds, 15 parts by weight of dichotoma, 15 parts by weight of catkins, 14 parts by weight of duckweed, 14 parts by weight of alum and 15 parts by weight of dandelion.

Wherein, the preparation method of traditional Chinese medicine additive comprises the following steps:

In the first step, all raw materials are mixed in proportion, crushed into powder, put into a multifunctional extraction tank, add ethanol with an alcohol concentration of 80% that is 5 times the mass of the mixture, heat and reflux for 3 hours to extract, and obtain an extract. The steam pressure in the heating and reflux process is 0.4MPa, and the extract is filtered to obtain the first filtrate and filter residue;

In the second step, add the filter residue obtained in the first step to ethanol with an alcohol concentration of 80% relative to the mass of the mixture in the first step, and heat and reflux for 1.5 hours to extract to obtain an extract. The vapor pressure during the heating and reflux process is 0.4MPa , filtering the extract to obtain a second filtrate;

The third step is to combine the first filtrate and the second filtrate, concentrate under reduced pressure to remove the solvent, and obtain a dry paste, put the dry paste into a spray dryer to dry, and ensure that the inlet air temperature is 170°C and the outlet air temperature is 60°C , and then crushed into 400 meshes to obtain traditional Chinese medicine additive powder.

The feed of the embodiment of the invention is made by following preparation method:

(1) Crushing step: weighing barley and wheat by weight percentage and putting them into a pulverizer for fine pulverization, passing through a 2.0mm sieve after pulverization;

(2) Ingredients step: mix yam powder, methionine, threonine, vitamin premix and traditional Chinese medicine additives according to the weight ratio, put into the mixer, mix evenly, and the mixing time is 20-30s;

(3) Granulation step: put it into a granulator for granulation, and the granulation temperature is 70°C to make the gelatinization degree reach more than 90%;

(4) Classification step: crushing, sieving and classification after granulation;

(5) Spraying step: spray the compound enzyme onto the surface of the crushed pellet feed.

Embodiment 2 Feed 2

The embodiment of the present invention provides a feed for preventing and treating swine erysipelas, which is composed of the following raw materials in parts by weight: 56 parts by weight of barley, 33 parts by weight of wheat, 7 parts by weight of compound enzyme, 15 parts by weight of yam powder, and 3 parts by weight of methionine parts, 3 parts by weight of threonine, 5 parts by weight of vitamin premix and 6 parts by weight of traditional Chinese medicine additives.

Among them, the compound enzyme is composed of dextranase, vitaminase and amylase with a weight ratio of 2:1:2; the main components of the vitamin premix are: vitamin A 1800IU/kg, vitamin D ₃ 270 IU/kg, Vitamin E89 IU/kg, vitamin K ₃ 0.5mg/kg, vitamin B ₁ 2.8mg/kg, vitamin B ₂ 4mg/kg, vitamin B ₆ 2mg/kg, vitamin B ₁₂ 21μg/kg, folic acid 0.6mg/kg, biological Vitamin 0.4mg/kg, niacin 29mg/kg, pantothenic acid 21mg/kg, cottonseed protein 8mg/kg, corn starch 11mg/kg, antioxidant 2mg/kg and probiotics 5mg/kg; traditional Chinese medicine additives are composed of the following raw materials: 15 parts by weight of honeysuckle, 23 parts by weight of hemp curd, 18 parts by weight of southern jujube, 15 parts by weight of trichosanthin, 15 parts by weight of garlic, 13 parts by weight of potato, 17 parts by weight of ants, 21 parts by weight of Dalun wood, 13 parts by weight of rhubarb, glutinous rice 13 parts by weight, 14 parts by weight of talc, 15 parts by weight of shegan, 12 parts by weight of mountain bean root, 15 parts by weight of Daqingye, 13 parts by weight of Tinglizi, 16 parts by weight of paeonol, 15 parts by weight of rehmannia, 16 parts by weight of Scrophulariaceae Parts by weight, 17 parts by weight of licorice, 18 parts by weight of almonds, 15 parts by weight of dichotoma, 15 parts by weight of catkins, 14 parts by weight of duckweed, 14 parts by weight of alum, 15 parts by weight of dandelion, 13 parts by weight of tangerine peel, 15 parts by weight of ground sand , 15 parts by weight of cloves and 15 parts by weight of hawthorn.

The preparation method of the traditional Chinese medicine additive comprises the following steps:

In the first step, all raw materials are mixed in proportion, crushed into powder, put into a multifunctional extraction tank, add ethanol with an alcohol concentration of 85% that is 4 times the mass of the mixture, heat and reflux for 2 hours to extract, and obtain an extract. The vapor pressure during the heating and reflux process is 0.5 MPa, and the extract is filtered to obtain the first filtrate and filter residue;

In the second step, add the filter residue obtained in the first step to ethanol with an alcohol concentration of 85% that is twice the mass of the mixture in the first step, heat and reflux for extraction for 1 hour, and obtain an extract, and the vapor pressure during the heating and reflux process is 0.5MPa , filtering the extract to obtain a second filtrate;

The third step is to combine the first filtrate and the second filtrate, concentrate under reduced pressure to remove the solvent to obtain a dry paste, put the dry paste into a spray dryer to dry, and ensure that the air inlet temperature is 180°C and the outlet air temperature is 70°C , and then crushed into 300 meshes to obtain traditional Chinese medicine additive powder.

Toxicity test

1. Acute toxicity test

According to the requirements of the acute toxicity test, the pre-test was carried out, and it was found that the LD50 of the test drug could not be measured. Therefore, the maximum dosage test in one day was carried out. Get above-mentioned 40 mice, after fasting without water for 12 hours, divide into administration group and water control group at random according to body weight, every group of 20, administration group gives the crude drug amount 2.4g containing the traditional Chinese medicine additive prepared in embodiment 1 The medicinal liquid of /ml concentration 0.4ml/10g, intragastric administration 2 times a day, makes the dosage reach 192.0g/kg in one day, and the water control group is given the same volume of water. After administration, the animals in each group had 5 animals in each box, were fed normally, and observed closely for seven consecutive days, recording possible toxic reactions and deaths. After administration, the mice had bright coats, normal behaviors, and no abnormal pathology. Sexual nerve reflex appeared, eating well in seven days, and no other abnormalities were seen. Compared with the water control group, there was no significant difference in body weight change and no animal died. Obvious gross pathological changes such as hemorrhage, tissue degeneration, and necrosis. Using the traditional Chinese medicine additive in Example 2 of the present invention to carry out the above test on mice, the result is the same as the test result of the traditional Chinese medicine additive in Example 1.

long-term toxicity test

The Chinese medicine additive aqueous solution of the embodiment of the present invention 1 is to mouse press 10.78, 20.35 and 33.48g crude drug/kg continuous gavage for 16 weeks (1.0ml/100g body weight, every day 2 times) and after drug withdrawal 4 weeks, the result shows: the present invention The traditional Chinese medicine additive in Example 1 had no significant effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of the mice, and no abnormal changes and histological examinations were found in the organs. The results showed that after 16 weeks of medication and 4 weeks after drug withdrawal, there was no significant change in the organs of the mice. It shows that the traditional Chinese medicine additive of the present invention has little toxicity to mice after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe. Using the traditional Chinese medicine additive in Example 2 of the present invention to carry out the above test on mice, the result is the same as the test result of the traditional Chinese medicine additive in Example 1.

Clinical Trials

1.1 Test materials

1.1.1 Test animals

In a pig farm in Weifang City, Shandong Province, 150 healthy piglets aged 3 months were randomly selected.

1.1.2 Tested strains

An individual pig farmer in Shandong Province found that piglets died, other piglets were depressed, high fever, no food, vomiting, conjunctival congestion, dry and hard feces with mucus, and irregular bright red spots in the armpits, thighs, and abdomen Blocks, fused together after acupressure fades. After the dead piglets were dissected, it was found that the fundus of the stomach and the pyloric membrane had diffuse bleeding and small spot bleeding; the whole intestinal tract had different degrees of catarrhal or hemorrhagic inflammation, and the spleen was enlarged, showing a typical septicemia. Liver and other diseased materials of dead pigs were aseptically sampled, inoculated with blood agar medium, and cultured at 37°C for 24 hours to observe the colony morphology, and then select suspicious colonies for pure culture. Microscopic examination shows Gram-positive small bacilli, most of which are slender and rod-shaped. Two suckling piglets were challenged with the isolated Erysipelas bacilli, and the symptoms of pig erysipelas were found after 24 hours, and it was determined that the dead piglets were caused by pig erysipelas. The isolated strain was used as the test strain.

1.1.3 Test drugs

Feed 1 of Example 1; Feed 2 of Example 2; traditional medicine: amoxicillin+Qingkailing injection.

1.2 Test method

1.2.1 Inoculation test

The cultured erysipelas strains were intravenously injected into 134 test piglets, all of which showed symptoms of erysipelas one day after infection, and 120 sick piglets were selected as experimental pigs.

1.2.2 Experimental grouping

120 diseased piglets were randomly divided into three groups, 40 in each group, namely Example Group 1, Example Group 2 and a control group.

1.2.3 Test method

Piglets with porcine erysipelas after infection were treated with different methods, wherein, Example Group 1 was treated with Feed 1 of Example 1 of the present invention, and used continuously for 4 days; Example Group 2 was treated with Feed 2 of Example 2 of the present invention. The treatment was used continuously for 4 days; the control group was treated with amoxicillin 2 g/50 kg body weight + Qingkailing injection 20 ml/50 kg body weight, once a day for 4 consecutive days, and fed with traditional feed.

1.2.4 Observation records

After infection, the clinical symptoms and pathological changes of piglets in each group were observed, and the number of deaths after infection and the therapeutic effect after treatment were recorded.

2 results

2.1 Curative effect standard

Cured: The spirit, appetite, body temperature, and defecation of the sick piglets all returned to normal, and the bright red plaques in the armpit, thigh, and abdomen disappeared;

Effective: The spirit, appetite, body temperature, and defecation of sick piglets all returned to normal, and the red plaques in the armpit, thigh, and abdomen improved significantly;

Ineffective: The symptoms of the sick piglets did not disappear or the condition worsened or even died.

Wherein, the effective rate is the sum of the cured and effective percentages.

2.2 The observation results are shown in Table 1.

Table 1 Comparison table of treatment results

group Number of deaths (only) cure (only) valid (only) void (only) Efficient(%) Example group 1 1 30 8 2 95.0% Example group 2 0 32 7 1 97.5% control group 3 20 12 8 80.0%

Can know from the data of table 1: compared with matched group, the feedstuff of embodiment 1 of the present invention and embodiment 2 have remarkable curative effect to the treatment of porcine erysipelas, side effect is low, the advantage of high therapeutic efficiency; Find in the long-term observation afterwards , embodiment group 1 and embodiment group 2 cured piglets relapse rate is obviously lower than the piglet of control group.

2.3 Post-infection symptoms and autopsy results

After infection, the symptoms of sick piglets are: lack of energy, high fever, no food, vomiting, conjunctival hyperemia, dry and hard feces with mucus, irregular bright red plaques in the armpits, thighs, and abdomen, and fading with finger pressure Then blend together. After the dead piglets were dissected, it was found that the fundus of the stomach and the pyloric membrane had diffuse bleeding and small spot bleeding; the whole intestinal tract had different degrees of catarrhal or hemorrhagic inflammation, and the spleen was enlarged, showing a typical septicemia.

specific case

Case 1

Two 3-month-old piglets in Qin’s family were found to be lack of energy and did not eat. One day later, they developed high fever, vomiting, and conjunctival hyperemia. Two days later, there were bright red plaques in the armpits and abdomen, which faded and merged with finger pressure. It was swine erysipelas, fed with the feed of Example 1 of the present invention, fed in a conventional manner, and used continuously for 3 days, and both pigs returned to normal.

Case 2

Of the 27 suckling piglets in a pig farm, 1 piglet died. Before the death, there were irregular bright red plaques in the armpit, inside the thigh, and inside the abdomen. Diffuse hemorrhage and spot hemorrhage occurred in the bottom and pyloric membrane; the whole intestinal tract had different degrees of catarrhal or hemorrhagic inflammation, splenomegaly, typical septic spleen, other piglets had loss of appetite, mental depression, Symptoms of bright red plaques appeared in the armpit, and it was diagnosed as porcine erysipelas. The feed of the embodiment of the present invention 2 was used to feed, and it was fed according to the normal feeding method. After 3 days of continuous use, 23 piglets all returned to normal, and continued treatment for 2 days. All 4 piglets returned to normal.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection of the present invention. within range.

Claims (5)

1. the feed for preventing and treating swine erysipelas, is characterized in that, described feed is made of the raw material of following parts by weight: 40-60 parts by weight of barley, 30-40 parts by weight of wheat, 5-9 parts by weight of compound enzyme, Chinese yam 10-20 parts by weight of powder, 2-4 parts by weight of methionine, 2-4 parts by weight of threonine, 4-6 parts by weight of vitamin premix and 4-9 parts by weight of traditional Chinese medicine additives; The traditional Chinese medicine additive is made of the following raw materials in parts by weight: 10-20 parts by weight of honeysuckle, 18-28 parts by weight of hemp tofu, 10-26 parts by weight of southern jujube, 10-20 parts by weight of trichosanthin, and 10-20 parts by weight of garlic 10-15 parts by weight of potatoes, 10-20 parts by weight of ants, 10-26 parts by weight of Dalun wood, 10-20 parts by weight of rhubarb, 10-15 parts by weight of glutinous rice, 10-26 parts by weight of talc, 10-25 parts by weight of dried Parts by weight, 10-15 parts by weight of mountain bean root, 10-20 parts by weight of Daqingye, 10-20 parts by weight of Tinglizi, 10-24 parts by weight of paeonol, 10-26 parts by weight of Rehmannia glutinosa, 10-20 parts by weight of Scrophulariaceae 20 parts by weight, 10 to 24 parts by weight of licorice, 10 to 24 parts by weight of almonds, 10 to 20 parts by weight of dichotoma, 10 to 20 parts by weight of catkins, 10 to 15 parts by weight of duckweed, 10 to 15 parts by weight of alum and 10 parts by weight of dandelion ~20 parts by weight. 2. the feed for preventing and treating porcine erysipelas according to claim 1, is characterized in that, described feed is made of the raw material of following parts by weight: 56 parts by weight of barley, 33 parts by weight of wheat, 7 parts by weight of compound enzyme, 15 parts by weight of yam powder, 3 parts by weight of methionine, 3 parts by weight of threonine, 5 parts by weight of vitamin premix and 6 parts by weight of traditional Chinese medicine additives. 3. The feed for preventing and treating swine erysipelas according to claim 1, wherein the Chinese medicine additive is made of the following raw materials in parts by weight: 12-17 parts by weight of honeysuckle, 19-25 parts by weight of hemp curd , 14-22 parts by weight of southern jujube, 13-18 parts by weight of trichosanthes, 12-17 parts by weight of garlic, 10-15 parts by weight of potatoes, 15-20 parts by weight of ants, 15-26 parts by weight of Dalun wood, 10-15 parts by weight of rhubarb Parts by weight, 10-15 parts by weight of glutinous rice, 10-18 parts by weight of talc, 10-21 parts by weight of dry root, 10-15 parts by weight of mountain bean root, 10-17 parts by weight of Daqingye, 10-16 parts by weight of Tinglizi , 12-20 parts by weight of paeonol, 13-18 parts by weight of Rehmannia glutinosa, 13-18 parts by weight of Scrophulariaceae, 13-21 parts by weight of licorice, 15-21 parts by weight of almond, 12-17 parts by weight of rehmannia, 12-12 parts by catkin 18 parts by weight, 13-15 parts by weight of duckweed, 13-15 parts by weight of alum and 13-17 parts by weight of dandelion. 4. the feed for preventing and treating porcine erysipelas according to any one of claims 1-3, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps: The first step is to mix all the raw materials in proportion, crush them into powder, put them into a multifunctional extraction tank, add ethanol with an alcohol concentration of 80% to 90% relative to the mass of the mixture, and heat to reflux for 1 hour to Extract for 3 hours to obtain the extract, the vapor pressure during the heating and reflux process is 0.4MPa-0.6MPa, filter the extract to obtain the first filtrate and filter residue; In the second step, add the filter residue obtained in the first step to ethanol with an alcohol concentration of 80% to 90% relative to the mass of the mixture in the first step, and heat to reflux for 0.5 to 1.5 hours to extract, obtain an extract, and heat to reflux The steam pressure in the process is 0.4MPa～0.6MPa, and the extract is filtered to obtain the second filtrate; The third step is to combine the first filtrate and the second filtrate, concentrate under reduced pressure to remove the solvent, and obtain a dry paste, put the dry paste into a spray dryer to dry, and ensure that the air inlet temperature is 170°C to 190°C, and the air outlet The temperature is 60° C. to 80° C., and then crushed into 200 mesh to 400 mesh to obtain traditional Chinese medicine additive powder. 5. a preparation method for the feed for preventing and treating porcine erysipelas as described in any one of claim 1-4, is characterized in that, described preparation method comprises the following steps: (1) Crushing step: weighing barley and wheat by weight percentage and putting them into a pulverizer for fine pulverization, passing through a 2.0mm sieve after pulverization; (2) Ingredients step: mix yam powder, methionine, threonine, vitamin premix and traditional Chinese medicine additives according to the weight ratio, put into the mixer, mix evenly, and the mixing time is 20-30s; (3) Granulation step: put it into a granulator for granulation, and the granulation temperature is 70°C to make the gelatinization degree reach more than 90%; (4) Classification step: crushing, sieving and classification after granulation; (5) Spraying step: spray the compound enzyme onto the surface of the crushed pellet feed.