CN103610991B - Medicine being used for the treatment of swine gastric ulcer and preparation method thereof - Google Patents
Medicine being used for the treatment of swine gastric ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine being used for the treatment of swine gastric ulcer and preparation method thereof, medicine comprises following crude drug: Radix Adenophorae (Radix Glehniae), Flammulina velutipes, Herba Dendrobii, cutter ash tree, Flos Lonicerae, Pericarpium Citri Reticulatae, Flos Caryophylli, Radix Ophiopogonis, Ipomoea batatas Lam., Fructus Gymnocladi Chinensis, Radix Kadsurae Coccineae, deliver vegetables, Radix Paeoniae, Nidus Vespae, Bulbus Allii, Endothelium Corneum Gigeriae Galli, Pulvis Fumi Carbonisatus, Fructus Setariae Germinatus and Fructus Jujubae.The invention has the beneficial effects as follows: relative to the medicine being used for the treatment of swine gastric ulcer of the prior art, medicine of the present invention has evident in efficacy to swine gastric ulcer treatment, and side effect is low, cure rate advantages of higher.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine being used for the treatment of swine gastric ulcer and preparation method thereof.
Background technology
Gastric ulcer refers in particular to the esophagus district ulcer of stomach.In recent years, common in the slaughter pig in slaughterhouse; In daily aquaculture management, also once ran into many cases, be wherein the subject matter causing pig farm pig death several times.Gastric ulcer is mainly limited to the esophagus district of stomach, and sick just visible mucomembranous surface corrugates, and becomes coarse, is very easily dyed Huang, yellowish-brown or green by bile or gastric content; And then mucous epithelium is destroyed, formed rotten to the corn, uneven; Finally form ulcer, hemorrhage.Esophagus district depression time serious, marginal swell becomes dike shape.The stomach of gastric ulcer expands more, follows the string in esophagus district; Gastric content is soft or aqueous; It is yellowish-brown when having hemorrhage; It is then soy sauce sample during severe haemorrhage.In diagnosed case, it is reported, being bred as group is owing to feeding particulate material; A group big porker is due to quick growth, and the main super several times amount of poultry has fed copper sulfate; High-temperature sterilization defatted milk is fed in one piglet field.Wherein feed the field of particulate material, gastrorrhagia, ulcer especially severe, tell chocolate gastric before death and hold, after cuing open inspection, in little intestinal content stomach function regulating, be coal tar oil sample thing.In addition, the reason that document is recorded also has and lacks selenium and vitamin E, treats that government official's time is long, crowded, nervous etc. before government official.1. 1. feed quality is not good for feedstuff, and feedstuff is coarse, mouldly loses, and is difficult to digestion, lacks nutrition; 2. a large amount of irritating mineral mixture is mixed in daily ration; 3. enough fibers are lacked in daily ration; 4. the ratio containing Semen Maydis in grain ration is too high, then its sickness rate is also higher; No matter Semen Maydis is through fine grinding, expansion or gel, and its sickness rate still has higher tendency.2. stressors primary disease is mainly in stable breeding pig, especially accepts a large amount of cereal and grows fast pig.Often being vulnerable to the stresses such as overcrowding, excessively agitation, just before giving birth front miscarriage causes neuro humor regulative mechanism disorderly.3. inherited genetic factors primary disease has very large heritability, grows pig that is fast and that carry on the back fat few relevant with selection-breeding.4. secondary factor swine fever, chronic pig erysipelas, ascaris suum infection, copper poisoning liver malnutrition, Fructus Mori sample heart disease etc., cause gastric mucosa congestion, hemorrhage, rotten to the corn, ulcer, thus Secondary cases gastric ulcer occurs.Only have according to symptom and cut open inspection diagnosis.Diagnosis can according to the characteristic sum symptom having hemorrhagic anemia, and pathology cuts open inspection and sees gastric extensive bleeding, and the dry feces of row's black, and specific apparatus inspection, make diagnosis as splanchnoscopy, hematological examination and stool examination.
Symptom: the 1. acute clinical symptom pig that loses is dead.Die from gastric mucosa hemorrhage more.Cut open fresh blood in the common stomach of inspection.2. subacute disease pig has significantly pale, Anemia, weak, anorexia and accelerated breathing, feces becomes from the sticky pasty state of black the bead being coated with mucus on a small quantity, sickly just to suffer from abdominal pain, grinds one's teeth in sleep, uneasy, sometimes there is vomiting, have blood in stool, dry stool is its common characteristic symptom.Do not rise sleepingly, how weak dead at 12 ~ 48h.3. chronic disease pig is due to Anemia of losing blood, palor, and feces turns black.The symptom of the chronic peritonitis that occurs together had.Cut open inspection and can see the excessive keratinization of gastric mucosa and epithelium strips off, have without real ulcer, but gastric had the aqueous content of volume.The sick stomach dye had has bile.
Current prophylactico-therapeutic measures: grain trough does not store too of a specified duration, from fungal contamination, because mycete can make unsaturated fatty acid content increase, thus easily sends out gastric ulcer.Cause as being that copper is excessive, the zinc carbonate of available 110ppm is as feed additive.(1) principle for the treatment of treatment is sedation-analgesia, antiacid only ferment, anti-inflammation hemostasia, improves raising, intensive care simultaneously.Improve and raise, be rich in the digestible feedstuff of nutrition, reduce stress.Ease the pain and reflexive stimulation.Oral tannic acid protection gastric mucosa, with in the antacids such as magnesium oxide and gastric acid, throws and takes bismuth subnitrate 2 ~ 6g and protect ulcer surface, prevent hemorrhage, Promotive union.(2) prevent prevention can strengthen feeding and management, provide complete feed, it is meticulous or excessively thick by fodder crushing to avoid, reduce various stress.
The side effect of Western medicine is larger, and, Western medicine only has obvious curative effect to single disease or a class disease when treating, for the disease that some diseases are more, curative effect may be just not too obvious, usually need out a lot of Western medicine, and, Western medicine is synthesis, price can be China's traditional medicine than a lot of Chinese herbal medicine of Chinese herbal medicine and Chinese patent medicine costliness naturally, for chemical synthetic drug, Chinese herbal medicine has plurality of active ingredients, not only there is toxicity low, not easily have side effects, but, at present, be used for the treatment of the feedstuff of pig lung plague and the therapeutic effect of relevant Chinese herbal medicine additive and not satisfactory.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of swine gastric ulcer and preparation method thereof, adopt this medicine to swine gastric ulcer treatment have efficient, toxic and side effects is little, noresidue, do not develop immunity to drugs, not contaminated air, short treating period and the not easily advantage such as recurrence.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of swine gastric ulcer, it is characterized in that, described medicine comprises following crude drug: Radix Adenophorae (Radix Glehniae), Flammulina velutipes, Herba Dendrobii, cutter ash tree, Flos Lonicerae, Pericarpium Citri Reticulatae, Flos Caryophylli, Radix Ophiopogonis, Ipomoea batatas Lam., Fructus Gymnocladi Chinensis, Radix Kadsurae Coccineae, deliver vegetables, Radix Paeoniae, Nidus Vespae, Bulbus Allii, Endothelium Corneum Gigeriae Galli, Pulvis Fumi Carbonisatus, Fructus Setariae Germinatus and Fructus Jujubae.
Described medicine is made up of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, to deliver vegetables 10-25 weight portion, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 15-25 weight portion.
Described medicine forms preferably by the raw material of following parts by weight: Radix Adenophorae (Radix Glehniae) 25-30 weight portion, Flammulina velutipes 14-21 weight portion, Herba Dendrobii 18-23 weight portion, cutter ash tree 18-27 weight portion, Flos Lonicerae 22-31 weight portion, Pericarpium Citri Reticulatae 27-32 weight portion, Flos Caryophylli 14-21 weight portion, Radix Ophiopogonis 16-20 weight portion, Ipomoea batatas Lam. 18-23 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, to deliver vegetables 13-20 weight portion, Radix Paeoniae 13-22 weight portion, Nidus Vespae 20-25 weight portion, Bulbus Allii 9-11 weight portion, Endothelium Corneum Gigeriae Galli 25-30 weight portion, Pulvis Fumi Carbonisatus 25-28 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 18-22 weight portion.
Described medicine is formed can also be preferably by the raw material of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portion, Flammulina velutipes 18 weight portion, Herba Dendrobii 21 weight portion, cutter ash tree 23 weight portion, Flos Lonicerae 26 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Flos Caryophylli 17 weight portion, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portion, Fructus Gymnocladi Chinensis 23 weight portion, Radix Kadsurae Coccineae 27 weight portion, to deliver vegetables 16 weight portions, Radix Paeoniae 18 weight portion, Nidus Vespae 23 weight portion, Bulbus Allii 10 weight portion, Endothelium Corneum Gigeriae Galli 27 weight portion, Pulvis Fumi Carbonisatus 27 weight portion, Fructus Setariae Germinatus 25 weight portion and Fructus Jujubae 20 weight portion.
Preferably, described medicine also comprises: Semen Vignae Cylindricae, Fructus Psoraleae and Rhizoma Alpiniae Officinarum.
Described medicine forms preferably by the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, to deliver vegetables 10-25 weight portion, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion, Fructus Jujubae 15-25 weight portion, Semen Vignae Cylindricae 10-20 weight portion, Fructus Psoraleae 10-15 weight portion and Rhizoma Alpiniae Officinarum 5-15 weight portion.
Described medicine is formed can also be preferably by the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portion, Flammulina velutipes 18 weight portion, Herba Dendrobii 21 weight portion, cutter ash tree 23 weight portion, Flos Lonicerae 26 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Flos Caryophylli 17 weight portion, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portion, Fructus Gymnocladi Chinensis 23 weight portion, Radix Kadsurae Coccineae 27 weight portion, to deliver vegetables 16 weight portions, Radix Paeoniae 18 weight portion, Nidus Vespae 23 weight portion, Bulbus Allii 10 weight portion, Endothelium Corneum Gigeriae Galli 27 weight portion, Pulvis Fumi Carbonisatus 27 weight portion, Fructus Setariae Germinatus 25 weight portion, Fructus Jujubae 20 weight portion, Semen Vignae Cylindricae 17 weight portion, Fructus Psoraleae 14 weight portion and Rhizoma Alpiniae Officinarum 8 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the medicine of swine gastric ulcer, described preparation method comprises the following steps: all crude drug are dropped in proportion blender and stir 30 ~ 50 minutes, fully mix, pulverize; The water relative to described mixture quality 2 ~ 4 times is added in the mixture after pulverizing, decoct 2 ~ 4 hours, filter, add in filtering residue and again decoct 1 ~ 2 hour relative to the water of 1 ~ 2 times, described mixture, filter, by twice filtrate mixing, concentrating under reduced pressure removing moisture, obtain dry mastic, dry with spray dryer further and pulverize, sieve acquisition 50 ~ 100 order fine drug powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: relative to the medicine being used for the treatment of swine gastric ulcer of the prior art, and medicine of the present invention has evident in efficacy to swine gastric ulcer treatment, and side effect is low, cure rate advantages of higher.
Detailed description of the invention
Chinese veterinarian thinks, swine gastric ulcer is mainly due to caused by stomach-QI being unable to descend normally " stagnation of QI and blood may bring about pain ".Sick position is at stomach, but dirty closely related with liver spleen two.Irritability easily violates stomach gram spleen, and taste can involve mutually.How real liver is clinically, and how empty spleen is, the many qi depressions to blood stasis of stomach.To treat flexibly according to the pathogenic characteristic of liver, spleen, stomach during prescriptions.Hyperactive liver-QI attacking the stomach person, should grasp the principle of " treating the liver can pacify stomach " " avoid just with soft ", accomplishes soothing the liverly not forget stomach function regulating, careful anti-impairment of YIN of regulating the flow of vital energy.Deficiency and coldness of spleen and stomach person, warming middle-JIAO and strengthening the spleen, should note crossing the product with for a long time with pungent fragrant warm-dryness syndrome." sour and sweet drugs can transforme into YIN " method is wanted for treatment deficiency of stomach-Yin is big, can not neglect.Be no matter the peptic ulcer of which type gastric abscess, it, all can enter network for a long time, forms obstruction of collaterals by blood stasis, therefore the Peptic Ulcers of prolonged illness, disperse blood stasis and dredge collateral, regulating QI to relieve pain can not be forgotten.The mechanism for the treatment of by Chinese herbs swine gastric ulcer is, dispersing the stagnated liver-QI for regulating the stomach, invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, improves immunity and the gastrointestinal peristalsis ability of pig.
Based on above-mentioned theory of Chinese medical science, the invention provides a kind of medicine for the treatment of swine gastric ulcer, comprise Radix Adenophorae (Radix Glehniae), Flammulina velutipes, Herba Dendrobii, cutter ash tree, Flos Lonicerae, Pericarpium Citri Reticulatae, Flos Caryophylli, Radix Ophiopogonis, Ipomoea batatas Lam., Fructus Gymnocladi Chinensis, Radix Kadsurae Coccineae, deliver vegetables, Radix Paeoniae, Nidus Vespae, Bulbus Allii, Endothelium Corneum Gigeriae Galli, Pulvis Fumi Carbonisatus, Fructus Setariae Germinatus and Fructus Jujubae.
Wherein, each crude drug pharmacology is as follows:
Radix Adenophorae (Radix Glehniae): sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, be mainly used in the few expectorant of dry cough of thermal burn lung yin or lung-dryness syndrome due to deficiency of YIN, consumptive lung disease is coughed, the apoplexy due to phlegm blood streak, and calentura injures the symptoms such as the withered thirsty and dry pharynx of stomach-Yin or prolonged illness deficiency of YIN Tianjin.
Flammulina velutipes: sweet; Salty; Cold in nature.Function cures mainly: tonifying liver; Benefit the intestines and stomach; Anticancer.Main hepatopathy; Gastrointestinal tract inflammation; Ulcer; Cancer.1. antitumor action: Flammulina velutipes Polysaccharides on Mice transplanted sarcoma S180, Murine Hepatoma22 and Leuis pulmonary carcinoma all have obvious anti-tumor activity, its action intensity is close with krestin, the tumor-inhibiting action of Flammukinan to S180 sarcoma has no pronounced amount effect relationship, may be immunomodulating because of its effect, but not direct killing oncocyte.It can grow by Tumor suppression, and neoplasm necrosis degree is increased, and glycogen content reduces, and tumor tissues acid nonspecific esterase vigor is declined.Mice lumbar injection every day Flammukinan 5mg/kg, continuous 10 days, obviously can suppress the growth of S180 solid tumor in Kunming mouse body of subcutaneous vaccination, tumour inhibiting rate was 39.5%-40%.From Flammulina velutiper (Fr.) Sing, separation obtains polysaccharide PA3DE (relative molecular mass 540,000) and PA5DE (relative molecular mass 47.1 ten thousand) and is respectively 50.2% and 46.7% to the suppression ratio of S180 sarcoma.In addition, carry out abstraction and purification, also obtain EA3 to Flammukinan, EA5, EA6 and EA7 tetra-components, wherein the suppression ratio of EA3 and EA5 to S180 sarcoma is respectively 82% and 84%.EA6 can strengthen the antineoplastic immune of Ehrlich tumor vaccine to BDF1 mice, extends the life-span inoculating 1000 Ehrlich tumor cell mouse.Oral EA6 can strengthen generation and the delayed hypersensitivity reaction of Sarcoma180 ICR mouse boosting cell anti-sheep red blood cell (SRBC) (SRBC) antibody IgM, when the used time same with tumor cryotherapy, the effect that this kind strengthens humoral and cellular immune response more shows, and can strengthen the effect of cryotherapy.But no matter separately oral or same with cryotherapy use, carbonic clearance experiment shows, EA6 can not strengthen mice reticuloendothelial system function.Another separation from golden mushroom mycelium obtains a kind of faintly acid containing more than 90% protein, the glycoprotein (proflamin) that relative molecular mass is about 13000 has the active anticancer shown, it has obvious effect to B-16 melanoma and adenocarcinoma 755, but do not have a cytotoxicity, this albumen of Mouse oral has no any obvious toxicity.Containing a kind of proteoglycan in Flammulina velutiper (Fr.) Sing carpophore, at 10mg/kg every day, under continuous 10 days dosage, it is 62.3% to the suppression ratio of S180 sarcoma.2. on the impact of immunologic function: Flammukinan 0.5-10 μ g/ml can show the generation of normal rat spleen lymphocyte proliferation that promotion concanavalin A (Con A) induces and interleukin-2 (IL-2), but heavy dose of (50 μ g/ml) has inhibitory action to the generation of IL-2, Flammukinan also can resist the inhibitory action that immunosuppressant hydrocortisone produces IL-2, and the part ability making suppressed lymphocyte produce IL-2 recovers.3. antifatigue effect: the mice taking Flammulina velutiper (Fr.) Sing certain hour, its Ldh Activity, muscle glycogen, hepatic glycogen content all show to be increased, after swimming exercise, blood lactase acid level and serum urea nitrogen content obviously reduce, postexercise recovery phase blood lactase acid clearance rate shows and raises, show that Flammulina velutiper (Fr.) Sing has the adaptability of enhancing body sports load, the effect that resisting fatigue produces and accelerates elimination of fatigue.4., on the impact of blood system: be separated to a kind of protease from Flammulina velutiper (Fr.) Sing, have the effect suppressing rat plasma condensation and promote fibrinolytic in vivo and in vitro, its effect is in concentration and dose dependent.But in vivo during administration, of short duration blood coagulation enhancing effect can be had.5. antiinflammatory action: the Polysaccharides on Mice auricle inflammatory model extracted in golden mushroom mycelium, sporophore has antiinflammatory action, and its anti-inflammatory activity strengthens with the increase of relative molecular mass, and fruitbody polysaccharide anti-inflammatory activity is higher than mycelium polysaccharides.6. other effects: the blood fat that Flammulina velutiper (Fr.) Sing can prevent animal to cause because of feed high cholesterol diet raises, and Flammulina velutiper (Fr.) Sing can also promote the synthesis of rat hemoglobin.7. toxicity: Flammulina velutiper (Fr.) Sing toxicity is minimum, the oral median lethal dose(LD 50) of rat and mouse is all greater than 20g/kg, continuous feeding 7 days, have no any toxic reaction, Salmonella reversion test is to TA97a, TA98, TA100 and TA102 tetra-bacterial strain result of the tests are feminine gender, cytogenetics detects and does not find to bring out chromosomal aberration effect to human peripheral blood lymphocytes, it is negative that sister chromosome monomer exchanges frequency, dosage 15g/kg is negative to rat bone marrow cell chromosomal aberration, dosage 5g/kg to the primary spermatocyte of mouse testis without bringing out chromosomal aberration effect.Rats gavaged golden needle fungus 0.01g/kg, 0.1g/kg, 1g/kg, 10g/kg, 20g/kg and 30g/kg 6 dosage groups, feed 50 days continuously, body weight is without rising appreciably, the heart, liver, spleen, lung, the equal no significant difference of kidney coefficient, each internal organs are compared all without obvious pathological change with matched group through pathology section examination.
Herba Dendrobii: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision." book on Chinese herbal medicine is newly organized ": Herba Dendrobii, sweet in the mouth, micro-hardship, cold nature is nontoxic.Unavailable bamboo dry measure used in former times, wooden dry measure used in former times, idle with it, Herba Dendrobii is frightened sedate, and beneficial smart reinforcing YIN-essence can be good for the power of foot knee joint especially, has been apt to numbness disease, has fallen the fire of the deficiency of YIN, have distinguished service greatly.This life, Wu's purgation doctor, quite liked with it, and people all over the world does not still know and knows its function.Lid Dendrobium nobile, be born among the grotto of Fujian, Guangdong, the ground of grotto and even the moon, and the side of Fujian, Guangdong Zhiyang is also, grasps Yinyang with life, thus cold be not cold, and impractical heat can be fallen.Husband's asthenic fire, Xiang Huoye, Xiang Huoyi mend, and should not rush down.Dendrobium nobile is wonderful is cold medicine, and has benefit, and its property is descending again, and not up.If fire mutually, easily rises, and does not easily fall person also, obtain Herba Dendrobii and then fall and do not rise.Between Xia Yue, the unable persons of two foots, take Herba Dendrobii then strong, Isn't that decline and hold concurrently and mend the bright of Zhiyin and test.Therefore with Cortex Phellodendri, Rhizoma Anemarrhenae reducing the minister-fire person, how about with Dendrobium nobile for working as.Lid Cortex Phellodendri, the Rhizoma Anemarrhenae are of no help in rushing down, and Dendrobium nobile invigorating middle warmer has and rushes down also.Or ask that the fire of the deficiency of YIN falls in Dendrobium nobile, be rush down the moon thing also, how can be good for the power of foot knee joint, wherein wonderful justice, not yet freely sends out.
Cutter ash tree: sweet; Property is put down.Hemostasia and promoting granulation; And liver spleen.Main traumatic hemorrhage; Spit blood; Spitting of blood; Furuncle; Infantile malnutrition; Eye conjunctivitis.
Flos Lonicerae: the loose poison of heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, Flos Lonicerae has the effect traditional Chinese medical science such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation and thinks, Flos Lonicerae is cold in nature, sweet in the mouth, gas flat, has effect of heat-clearing and toxic substances removing, can treat the disease such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay the pathological changes effect of Respirovirus to cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Caused by the endotoxin that Flos Lonicerae preparation lumbar injection obviously can reduce bacillus pyocyaneus, the leukocyte count of rabbit declines, and deviation to the left phenomenon etc. has obvious antagonism.Flos Lonicerae compatibility Radix Scutellariae is prepared into poisoning symptom and the death that preparation obviously can alleviate bacillus pyocyaneus endotoxin caused rabbit.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and the disease such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur.Be good at drying dampness to eliminate phlegm again, be control the conventional key medicine that damp-phlegm stops up lung, abundant expectoration cough, reduce for insufficiency of the spleen diet, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea.Because it can spleen invigorating, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, Pericarpium Citri tangerinae again can with in, stomach-QI being unable to descend normally, nausea and vomiting can be controlled.
Flos Caryophylli: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm." Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." enter stomach, spleen, kidney channel." Japan hanako materia medica ": control implication, regurgitation, treats kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, and warm waist knee joint, kill alcoholism, disappear mass beside the umbilicus, except consumptive disease with cold nature.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, be slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation." Mingyi Bielu " is recorded: treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, xerostomia excessive thirst, anti-nausea, and more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted, protects god, determine lung qi, settling five organs, makes us fertile strong." book on Chinese herbal medicine is newly organized " is recorded: Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, the smart reinforcing YIN-essence of benefit, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, and what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often few use and can not be successfully unfortunate also.Do not know that Radix Ophiopogonis must be multiplex, strength begins large, and Gai Huofu is in lung, and sparkle liquid in doing, more than Radix Ophiopogonis, then fire can not be made; Heat is vehement in stomach, and endure its moon to the greatest extent, more than Radix Ophiopogonis, then fire can not cease.More have the fire of bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to bladder heat also, do not imitate with the medicine of water flowing, do not imitate with the agent of pathogenic fire reducing, this again what with? the gas of lid bladder, must the respectful clearly order row of the part of the body cavity above the diaphragm housing the heart and lungs, and fire is decline, and water is lower logical.The respectful clearly order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, and heat of the lung, then making that lung is respectful is clearly not all right, and bladder fire closes, and water also closes.Therefore for logical bladder person, must the gas of lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpful, if eventually not Radix Ophiopogonis clear in have benefit, the fire of bladder can be rushed down, and don't damage the gas of bladder, but few with it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and the beginning has Ji also.
Ipomoea batatas Lam.: invigorating middle warmer and blood; Supplementing QI for promoting the production of body fluid; Wide the intestines and stomach; Relieving constipation is secret.1. " detailed outline lifts something lost ": invigorating middle warmer, and blood, warming the stomach, fertile the five internal organs.Rhizoma Euonymus plain boiled pork person, lung benefiting gas promotes the production of body fluid.Jia Niujiang a slice when boiling, advises together with Rhizoma Zingiberis Recens Fructus Jujubae in tune; (together) Flos Carthami is cooked, and can manage spleen blood, makes not leak.2. " book on Chinese herbal medicine asks former ": removing heat from blood and promoting blood circulation, wide the intestines and stomach, relieving constipation is secret, removes place stasis of blood dysentery, relaxing muscles and tendons network, and hemostasis heat is thirsty, and puerpera is the most suitable.With fish, Channa argus food, tonify deficiency in tune.3. " occupy diet spectrum with breath ": tonifying the spleen and stomach of cooking, physical strength profiting, imperial wind and cold, beneficial color.All note ship persons that sails across a sea, no matter raw ripe, namely lack of appetite pacifies perhaps.4. " south of the Five Ridges gather medicinal herbs record ": vinegar boils clothes, control whole body to swell.
Fructus Gymnocladi Chinensis: pungent, temperature.Function cures mainly: except pertinacious phlegm, washs dirt greasy.Control cough expectorant stalk, dysentery, hemorrhoidal hamorrhage, inguinal bubo, head sore, scabies.1. " detailed outline ": curing rheumatism, dysentery, has blood in stool, skin ulcer, tinea, toxic swelling.2. " illustrated handbook planted by middle traditional Chinese medicines ": eliminate the phlegm.Control cough expectorant plug.
Radix Kadsurae Coccineae: pungent micro-hardship, temperature.Circulation of qi promoting, invigorates blood circulation, dissipating blood stasis, pain relieving.Control acute gastroenteritis, chronic gastritis, gastric and duodenal ulcers, rheumatic ostalgia, dysmenorrhes, puerperal, the stasis of blood was stagnant, traumatic injury, and knife injury is hemorrhage.1. " south of the Five Ridges gather medicinal herbs record ": eliminating blood stasis to promote regeneration of blood.Control women through front and back belly pain, puerperal exposure to wind fan, cholera is vomited and diarrhoea and is knotted.2. " register planted by Guangxi medicine ": hemostasis, enrich blood.Control knife injury, uterine prolapse.3. Guangzhou army " conventional Chinese herbal medicine handbook ": promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, detumescence of dispeling the wind.Control chronic gastritis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic ostalgia, traumatic injury paralysis pain, premenstrual abdominal pain, puerperal the stasis of blood pain, edema.
Deliver vegetables: sweet in flavor and cold in property, nontoxic.Enter liver, kidney, urinary bladder channel.Can diuresis, heat clearing away, hard masses softening and resolving, the scale removal of reason intestinal, disappear stagnant blood pressure lowering.According to introduction in traditional Chinese medical science books, deliver vegetables to thyromegaly, lymphoid tuberculosis, vitamin B1 deficiency, epistaxis, iron deficiency anemia, hypertension and gynaecopathia etc. have certain curative effect.The color of delivering vegetables is very black, plain, but interior contained irony of delivering vegetables is higher, boiling soup and cooking, can enrich blood with delivering vegetables.Research finds, delivers vegetables and also has ascarifuge, blood fat reducing function.It also has bowel relieving stomach, digestant effect.Patient after having an operation, eats of and delivers vegetables, and wound can comparatively fast heal.There is heat clearing away to disappear effect of stagnant, softening and eliminating sputum, the scale removal of reason intestinal.Deliver vegetables and also there is blood pressure lowering.Regulating the multiple effects such as neural, is hypertension, the desirable food of coronary heart disease, high fat of blood patient.Pharmaceutically purposes is very wide, and among the people commonly using delivers vegetables to treat the diseases such as rickets, gynaecological disease, dysentery, hypertension, tracheitis, epistaxis, malnutrition, and especially Post operation eats, and has special-effect to promotion wound healing.
Radix Paeoniae: bitter, sour, is slightly cold; Return liver, spleen channel.There is the effect of the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, suppressing liver-YANG.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.To the effect coronary artery dilator of cardiovascular system, reducing blood pressure, (d-cachou extract and progallin A have antithrombotic and antiplatelet aggregative activity; Liver protection effect has obvious protective effect to hepatic injury caused by carbon tetrachloride, AFB1, D-galactosamine; Spasmolysis has inhibitory action to intestinal tube and stomach in place motion, significantly resists the uterine contraction that oxytocin causes; Analgesic activity can suppress mouse writhing, shouts, hot plate reaction, suppresses writhing response to have synergism to morphine, and can resist that pentylenetetrazole is caused faints from fear.
Nidus Vespae: sweet is flat.Return stomach warp.Function cures mainly: dispel the wind, merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.
Bulbus Allii: pungent, temperature.Function cures mainly: stomach invigorating, dysentery relieving, cough-relieving, sterilization, anthelmintic.Prevention influenza, epidemic cerebrospinal meningitis.Control pulmonary tuberculosis, pertussis, inappetence, dyspepsia, bacillary dysentery, amebic dysentery, enteritis, enterobiasis, ancylostomiasis; Trichomonas vaginitis is controlled in external, acute appendicitis.
Endothelium Corneum Gigeriae Galli: sweet, cold, return spleen, stomach, small intestinal, urinary bladder channel, for promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.
Pulvis Fumi Carbonisatus: pungent, temperature.Function cures mainly: hemostasis, antidiarrheal.For spitting blood, spitting of blood, has blood in stool, dysfunctional uterine hemorrhage, diarrhoea, food stagnation dysentery.Traumatic hemorrhage is controlled in external, epistaxis.
Fructus Setariae Germinatus: sweet, temperature.Return spleen, stomach warp.Function cures mainly: help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.It is stagnant that Fructus Setariae Germinatus (parched to brown) is apt to eliminate indigestion, do not disappear for stagnant.
Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, display Fructus Jujubae has same immunosuppressant with azathioprine; The generation of antibody can be suppressed to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and other effects of inhibitory action are not produced to non-reacted antibody: the two glucoside A of the flavone in Fructus Jujubae, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and Fructus Jujubae has the effect increasing cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.The swimming time of mice can be extended.Nearest report Fructus Jujubae has the proliferation function of anticancer.
In order to reach better therapeutic effect, formula of the present invention can also comprise: Semen Vignae Cylindricae, Fructus Psoraleae and Rhizoma Alpiniae Officinarum.
Semen Vignae Cylindricae: enter spleen, kidney channel.Function cures mainly: QI invigorating in tune, tonifying speen and tonifying kidney.1. " grandson true man's contraindication of food ": " nephropathy should be eaten." 2. the Meng numerous: " tonifying five ZANG-organs, in tune, helps the twelve regular channels." 3. " Japan hanako materia medica ": " bean, warm the intestines and stomach.Leaf, sharp the five internal organs, the therapeutic method to keep the adverse QI flowing downwards."
Fructus Psoraleae: kidney returned by Fructus Psoraleae; The heart; Spleen; Stomach; Lung meridian.Show that Fructus Psoraleae stimulates keratinocyte release inflammatory mediator according to the study, act on melanophore somatomedin, make remaining melanocyte proliferation in epidermis or hair follicle; Fructus Psoraleae acrid in the mouth; Bitter in the mouth; Warm in naturely return through kidney; Pericardium; Spleen; Stomach; Lung meridian function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence essence; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea." Bencao Jingshu ": Fructus Psoraleae, energy warming the kidney; Raw sun in the moon, the key medicine of excessive fire benefit soil also.Its main five kinds of strain and seven kinds of impairment, the disease of lid edge impairment caused by overstrain, a lot of in asthenia of both the spleen and kidney, with its can warming the kidney, mend fire with the immature soil, then in kidney kidney-Yang be so incensed that mend and rise, then can digesting food, steam waste matter and change precise and tiny.Spleen-QI transporting the essence to the whole body is attributed to lung, supports the five internal organs with honor, therefore the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, and the then air-cooled visitor that takes advantage of a weak point in opponent's defence so that bone marrow wound loses, the cold essence stream of kidney, and kidney governing bones store essential substances, marrow be essence this, the gas of kidney-Yang is solid, and namely, card is shown in, solid itself and yang-energy life, then front card removes in vain.Man is based on essence, and married woman is based on blood, and married woman vim and vigour person, also still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, and the cold essence stream of the kidney with man also.
Rhizoma Alpiniae Officinarum: bitter, cold.Function cures mainly: heat clearing away, regulates the flow of vital energy, pain relieving.For acute gastroenteritis, dyspepsia, heatstroke is suffered from abdominal pain, stomachache.
Embodiment 1 medicine 1
By Radix Adenophorae (Radix Glehniae) 28g, Flammulina velutipes 18g, Herba Dendrobii 21g, cutter ash tree 23g, Flos Lonicerae 26g, Pericarpium Citri Reticulatae 29g, Flos Caryophylli 17g, Radix Ophiopogonis 18g, Ipomoea batatas Lam. 21g, Fructus Gymnocladi Chinensis 23g, Radix Kadsurae Coccineae 27g, the 16g that delivers vegetables, Radix Paeoniae 18g, Nidus Vespae 23g, Bulbus Allii 10g, Endothelium Corneum Gigeriae Galli 27g, Pulvis Fumi Carbonisatus 27g, Fructus Setariae Germinatus 25g and Fructus Jujubae 20g drop into blender, stir 40 minutes, abundant mixing, pulverizes; The water relative to described mixture quality 3 times is added in the mixture after pulverizing, decoct 3 hours, filter, add in filtering residue and again decoct 1 hour relative to the water of 2 times, described mixture, filter, by twice filtrate mixing, concentrating under reduced pressure removing moisture, obtain dry mastic, dry with spray dryer further and pulverize, sieve acquisition 80 order fine drug powder.
Embodiment 2 medicine 2
By Radix Adenophorae (Radix Glehniae) 28g, Flammulina velutipes 18g, Herba Dendrobii 21g, cutter ash tree 23g, Flos Lonicerae 26g, Pericarpium Citri Reticulatae 29g, Flos Caryophylli 17g, Radix Ophiopogonis 18g, Ipomoea batatas Lam. 21g, Fructus Gymnocladi Chinensis 23g, Radix Kadsurae Coccineae 27g, the 16g that delivers vegetables, Radix Paeoniae 18g, Nidus Vespae 23g, Bulbus Allii 10g, Endothelium Corneum Gigeriae Galli 27g, Pulvis Fumi Carbonisatus 27g, Fructus Setariae Germinatus 25g, Fructus Jujubae 20g, Semen Vignae Cylindricae 17g, Fructus Psoraleae 14g and Rhizoma Alpiniae Officinarum 8g drop into blender, stir 50 minutes, abundant mixing, pulverizes; The water relative to described mixture quality 4 times is added in the mixture after pulverizing, decoct 3 hours, filter, add in filtering residue and again decoct 2 hours relative to the water of 2 times, described mixture, filter, by twice filtrate mixing, concentrating under reduced pressure removing moisture, obtain dry mastic, dry with spray dryer further and pulverize, sieve acquisition 100 order fine drug powder.
Toxicity test
Select SD rat, give the medicine dissolution liquid of the embodiment of the present invention 1 of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, and the dose safety of the clinical practice of the prompting embodiment of the present invention 1 medicine 1 is higher.Adopt identical test method to carry out toxicity test to the medicine of the embodiment of the present invention 2, the dose safety of the clinical practice of the same proof embodiment of the present invention 2 medicine 2 is higher.
Clinical trial
(1) laboratory animal
Pig farm, Zibo City of Shandong Province found to fatten the phenomenon that pig sudden death appears in swinery in August, 2012, clinical examination is carried out to swinery, find that in swinery, some pig occurs that inappetence, spirit are poor and many with vomiting phenomenon, sick dead pig occurs discharging color of soy sauce loose stool before death, abnormal smells from the patient is smelt as of rotten fish, with vomiting and vomitus mostly is the chyme being mixed with blood, find after dissecting that blood is thin, there is the circle that differs in size or oval ulcer surface in stomach cardia district, ulcer surface is brown, chap, stomach base area large-area hemorrhage.On inspection, there are 200 pigs nearly to suffer from gastric ulcer, select 162 body weight in the ill pig experiment pig the most of about 75kg.
(2) test method
By 162 ill pigs with entering to be divided into three experimental grouies, often organize 54, often organizing average weight is 75kg.Three components does not use the medicine 1(embodiment group 1 of the embodiment of the present invention 1), the medicine 2(embodiment group 2 of embodiment 2) and conventional medicament (matched group) treat.Medicine 1 and medicine 2 are added feedstuff according to the percentage by weight of feedstuff 3-8% by embodiment 1 and 2 respectively; Conventional medicament is mixed into feedstuff after selecting bismuth subnitrate sheet to pulverize, and mixed volume is 1-3g/ head.Test period is 5-7 days.
(3) criterion of therapeutical effect
Effective: the treatment time limit is for mostly to be most 5 days, and appetite, spirit and defecation etc. all recover normally, symptoms of emesis disappears; Effective: the treatment time limit is 6 days or 7 days, and appetite takes a turn for the better to some extent, mental restoration is normal, and feces is normal, without vomiting phenomenon; Invalid: inappetence, spirit is not improved, and still has vomiting phenomenon.
(4) therapeutic outcome
The results are shown in Table 1, from therapeutic effect, adopt medicine of the present invention to be 97.6% to the treated effect of swine gastric ulcer, higher than matched group.
Data as can be seen from table 1: compared with matched group, use the Drug therapy swine gastric ulcer of the embodiment of the present invention 1 and embodiment 2, have treatment time short, the advantage such as therapeutic effect is good.
Concrete case
Case 1
In July, 2012, there are 52 years old sows in Wu family due to the busy not free purchase perfect compound feed of housework, only to feed Semen Maydis powder, feed about two weeks, find that the symptom of anemia, vomiting, inappetence and spirit depression all appears in 5 sows, and feces becomes Colophonium sample, wherein there is a sow to occur haematemesis phenomenon once in a while, be diagnosed as gastric ulcer.In feedstuff, add the medicine of the embodiment of the present invention 1 of feedstuff gross weight 8%, adhere to use 6 days, 5 sows all recover normal, and normally, Anemia disappears for appetite and mental restoration.
Case 2
In July, 2011, Lee's raiser 121 growing and fattening pigs, there is inappetence, the symptom that spirit is low in the pig of nearly 70, even have indivedual pig hematemesis, skin whitening, body temperature is normal, two pig death.Find through censorship, the circle that differing in size appears in the Gaster Sus domestica cardia district that dies of illness or oval ulcer surface, ulcer surface is brown, chaps, and stomach base area large-area hemorrhage, is diagnosed as gastric ulcer.In feedstuff, add the medicine of the embodiment of the present invention 2 of feedstuff gross weight 5%, adhere to use 5 days, 51 ill pigs all recover normal, normally, Anemia disappears for appetite and mental restoration, and several ill pigs continue use two days in addition, also all recover normal, transference cure.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. be used for the treatment of the medicine of swine gastric ulcer, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, to deliver vegetables 10-25 weight portion, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 15-25 weight portion.
2. the medicine being used for the treatment of swine gastric ulcer according to claim 1, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 25-30 weight portion, Flammulina velutipes 14-21 weight portion, Herba Dendrobii 18-23 weight portion, cutter ash tree 18-27 weight portion, Flos Lonicerae 22-31 weight portion, Pericarpium Citri Reticulatae 27-32 weight portion, Flos Caryophylli 14-21 weight portion, Radix Ophiopogonis 16-20 weight portion, Ipomoea batatas Lam. 18-23 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, to deliver vegetables 13-20 weight portion, Radix Paeoniae 13-22 weight portion, Nidus Vespae 20-25 weight portion, Bulbus Allii 9-11 weight portion, Endothelium Corneum Gigeriae Galli 25-30 weight portion, Pulvis Fumi Carbonisatus 25-28 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 18-22 weight portion.
3. the medicine being used for the treatment of swine gastric ulcer according to claim 1, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portion, Flammulina velutipes 18 weight portion, Herba Dendrobii 21 weight portion, cutter ash tree 23 weight portion, Flos Lonicerae 26 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Flos Caryophylli 17 weight portion, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portion, Fructus Gymnocladi Chinensis 23 weight portion, Radix Kadsurae Coccineae 27 weight portion, to deliver vegetables 16 weight portions, Radix Paeoniae 18 weight portion, Nidus Vespae 23 weight portion, Bulbus Allii 10 weight portion, Endothelium Corneum Gigeriae Galli 27 weight portion, Pulvis Fumi Carbonisatus 27 weight portion, Fructus Setariae Germinatus 25 weight portion and Fructus Jujubae 20 weight portion.
4. be used for the treatment of the medicine of swine gastric ulcer, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, to deliver vegetables 10-25 weight portion, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion, Fructus Jujubae 15-25 weight portion, Semen Vignae Cylindricae 10-20 weight portion, Fructus Psoraleae 10-15 weight portion and Rhizoma Alpiniae Officinarum 5-15 weight portion.
5. the medicine being used for the treatment of swine gastric ulcer according to claim 4, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portion, Flammulina velutipes 18 weight portion, Herba Dendrobii 21 weight portion, cutter ash tree 23 weight portion, Flos Lonicerae 26 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Flos Caryophylli 17 weight portion, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portion, Fructus Gymnocladi Chinensis 23 weight portion, Radix Kadsurae Coccineae 27 weight portion, to deliver vegetables 16 weight portions, Radix Paeoniae 18 weight portion, Nidus Vespae 23 weight portion, Bulbus Allii 10 weight portion, Endothelium Corneum Gigeriae Galli 27 weight portion, Pulvis Fumi Carbonisatus 27 weight portion, Fructus Setariae Germinatus 25 weight portion, Fructus Jujubae 20 weight portion, Semen Vignae Cylindricae 17 weight portion, Fructus Psoraleae 14 weight portion and Rhizoma Alpiniae Officinarum 8 weight portion.
6. the preparation method being used for the treatment of the medicine of swine gastric ulcer according to any one of claim 1-5, is characterized in that, described preparation method comprises the following steps: all crude drug are dropped in proportion blender and stir 30 ~ 50 minutes, fully mix, pulverize; The water relative to described mixture quality 2 ~ 4 times is added in the mixture after pulverizing, decoct 2 ~ 4 hours, filter, add in filtering residue and again decoct 1 ~ 2 hour relative to the water of 1 ~ 2 times, described mixture, filter, by twice filtrate mixing, concentrating under reduced pressure removing moisture, obtain dry mastic, dry with spray dryer further and pulverize, sieve acquisition 50 ~ 100 order fine drug powder.
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| Title |
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| 胃溃疡的辨证论治;王养才等;《实用医技杂志》;20080430;第15卷(第11期);1453-1454 * |
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| CN103610991A (en) | 2014-03-05 |
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