CN103610991A - Medicine for treating swine gastric ulcer and preparation method thereof - Google Patents
Medicine for treating swine gastric ulcer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating swine gastric ulcer and a preparation method thereof. The medicine is prepared from the following raw material medicines: the roots of straight ladybell, winter mushrooms, dendrobe, fruits of goldenshower senna, honeysuckles, pericarpium citri reticulatae, syzygium aromaticum, radix ophiopogonis, sweet potatoes, gymnocladus chinensis, scarlet kadsura roots, nostoc commune, Chinese herbaceous peony, nidus vespae, garlic, endothelium corneum gigeriae galli, plant soot, rice sprouts and Chinese dates. The medicine disclosed by the invention has the beneficial effects that compared with the medicines for treating swine gastric ulcer in the prior art, the medicine for treating swine gastric ulcer has the advantages of remarkable curative effect, low side effect, high cure rate and the like.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of Gaster Sus domestica ulcer and preparation method thereof.
Background technology
Gastric ulcer refers in particular to the esophagus district ulcer of stomach.In recent years, common in the slaughter pig in slaughterhouse; In daily aquaculture management, also once running into many cases, is wherein the subject matter that causes pig farm pig death several times.Gastric ulcer is mainly limited to the esophagus district of stomach, and sick just visible mucomembranous surface corrugates, and becomes coarse, very easily by bile or gastric content, is dyed Huang, yellowish-brown or green; And then mucous epithelium is destroyed, form rotten to the corn, uneven; Finally form ulcer, hemorrhage.Esophagus district depression when serious, marginal swell becomes dike shape.The stomach of gastric ulcer expands more, follows the string in esophagus district; Gastric content is soft or aqueous; Having when hemorrhage is yellowish-brown; It during severe haemorrhage, is soy sauce sample.In diagnosed case, it is reported, being bred as group is owing to feeding particulate material; A group big porker is due to Fast Growth, and the main super several times amount of poultry has been fed copper sulfate; High-temperature sterilization defatted milk is fed in one piglet field.Wherein feed the field of particulate material, gastrorrhagia, ulcer especially severe, tell before death chocolate gastric and hold, and cuts open the rear small intestinal content of inspection and gastric and be coal tar oil sample thing.In addition, the reason of recording on document also have to lack selenium and vitamin E, treats that government official's time is long, crowded, nervous etc. before government official.1. 1. feed quality is not good for feedstuff, and feedstuff is coarse, and mould losing is difficult to digestion, lacks nutrition; 2. in daily ration, sneak into a large amount of irritating mineral mixture; 3. in daily ration, lack enough fibers; 4. in corn daily ration, the ratio containing Semen Maydis is too high, and its sickness rate is also higher; No matter Semen Maydis is through fine grinding, expansion or gel, its sickness rate still has higher tendency.2. stressors primary disease is mainly in stable breeding pig, especially accepts a large amount of cereals and the fast pig of growth.Often be vulnerable to overcrowding, excessively agitation, just before giving birth before the stress such as miscarriage cause that neuro humor regulative mechanism is disorderly.3. inherited genetic factors primary disease has very large heritability, with selection-breeding growth pig fast and that back of the body fat is few relevant.4. secondary factor swine fever, chronic pig erysipelas, ascaris suum infection, copper poisoning liver malnutrition, Fructus Mori sample heart disease etc., cause gastric mucosa congestion, hemorrhage, rotten to the corn, ulcer, thereby Secondary cases gastric ulcer occurs.Only have according to symptom and cut open inspection diagnosis.Diagnosis can be according to the feature and the symptom that have hemorrhagic anemia, and pathology cuts open inspection and sees gastric extensive bleeding, and the dry feces of row's black, and specific apparatus inspection, make diagnosis as splanchnoscopy, hematological examination and stool examination.
Symptom: the 1. acute clinical symptom pig that loses is dead.Die from gastric mucosa hemorrhage more.Cut open fresh blood in the common stomach of inspection.2. subacute disease pig has significantly pale, Anemia, weak, anorexia and accelerated breathing, feces becomes from the sticky pasty state of black the bead that is coated with on a small quantity mucus, sickly just suffers from abdominal pain, grinds one's teeth in sleep, uneasiness, sometimes there is vomiting, have blood in stool, dry stool is its common characteristic symptom.Do not rise sleepingly, how weak dead at 12～48h.3. chronic disease pig is due to the Anemia of losing blood, palor, feces blackout.The symptom of the chronic peritonitis that occurs together having.Cut open that inspection can be seen the excessive keratinization of gastric mucosa and epithelium strips off, have without real ulcer, but gastric had the aqueous content of volume.The sick stomach having dyes and has bile.
Current prophylactico-therapeutic measures: grain trough does not store too of a specified duration, avoids fungal contamination, increases because mycete can make unsaturated fatty acid content, thereby easily sends out gastric ulcer.As to be that copper is excessive cause, the zinc carbonate of available 110ppm is as feed additive.(1) principle for the treatment of treatment is sedation-analgesia, antiacid only ferment, anti-inflammation hemostasia, improves raising, intensive care simultaneously.Improve and raise, be rich in the digestible feedstuff of nutrition, reduce stress.Ease the pain and reflexive stimulation.Oral tannic acid protection gastric mucosa, with in the antacids such as magnesium oxide and gastric acid, throws and takes bismuth subnitrate 2～6g protection ulcer surface, prevents hemorrhagely, promotes healing.(2) prevention prevention can be strengthened feeding and management, and complete feed is provided, and avoids that fodder crushing is meticulous or excessively thick, reduce various stress.
The side effect of Western medicine is larger, and, Western medicine only has obvious curative effect to single disease or a class disease when treatment, for the more disease of some diseases, curative effect may be just not too obvious, usually need out a lot of Western medicine, and, Western medicine synthesizes, price can be China's traditional medicine than a lot of Chinese herbal medicine of Chinese herbal medicine and Chinese patent medicine costliness naturally, for chemical synthetic drug, Chinese herbal medicine has plurality of active ingredients, not only there is toxicity low, be difficult for having side effects, but, at present, be used for the treatment of the feedstuff of pig lung plague and the therapeutic effect of relevant Chinese herbal medicine additive not satisfactory.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of medicine that is used for the treatment of Gaster Sus domestica ulcer and preparation method thereof, adopt this medicine to Gaster Sus domestica ulcer treatment have efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, not contaminated air, short treating period and be difficult for the advantages such as recurrence.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of Gaster Sus domestica ulcer, it is characterized in that, described medicine comprises following crude drug: Radix Adenophorae (Radix Glehniae), Flammulina velutipes, Herba Dendrobii, cutter ash tree, Flos Lonicerae, Pericarpium Citri Reticulatae, Flos Caryophylli, Radix Ophiopogonis, Ipomoea batatas Lam., Fructus Gymnocladi Chinensis, Radix Kadsurae Coccineae, deliver vegetables, Radix Paeoniae, Nidus Vespae, Bulbus Allii, Endothelium Corneum Gigeriae Galli, Pulvis Fumi Carbonisatus, Fructus Setariae Germinatus and Fructus Jujubae.
Described medicine is comprised of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, the 10-25 weight portion of delivering vegetables, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 15-25 weight portion.
Described medicine is formed and is preferably by the raw material of following parts by weight: Radix Adenophorae (Radix Glehniae) 25-30 weight portion, Flammulina velutipes 14-21 weight portion, Herba Dendrobii 18-23 weight portion, cutter ash tree 18-27 weight portion, Flos Lonicerae 22-31 weight portion, Pericarpium Citri Reticulatae 27-32 weight portion, Flos Caryophylli 14-21 weight portion, Radix Ophiopogonis 16-20 weight portion, Ipomoea batatas Lam. 18-23 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, the 13-20 weight portion of delivering vegetables, Radix Paeoniae 13-22 weight portion, Nidus Vespae 20-25 weight portion, Bulbus Allii 9-11 weight portion, Endothelium Corneum Gigeriae Galli 25-30 weight portion, Pulvis Fumi Carbonisatus 25-28 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 18-22 weight portion.
Described medicine is formed and can also be preferably by the raw material of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portions, Flammulina velutipes 18 weight portions, Herba Dendrobii 21 weight portions, cutter ash tree 23 weight portions, Flos Lonicerae 26 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Flos Caryophylli 17 weight portions, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portions, Fructus Gymnocladi Chinensis 23 weight portions, Radix Kadsurae Coccineae 27 weight portions, 16 weight portions of delivering vegetables, Radix Paeoniae 18 weight portions, Nidus Vespae 23 weight portions, Bulbus Allii 10 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Pulvis Fumi Carbonisatus 27 weight portions, Fructus Setariae Germinatus 25 weight portions and Fructus Jujubae 20 weight portions.
Preferably, described medicine also comprises: Semen Vignae Cylindricae, Fructus Psoraleae and Rhizoma Alpiniae Officinarum.
Described medicine is formed and is preferably by the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, the 10-25 weight portion of delivering vegetables, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion, Fructus Jujubae 15-25 weight portion, Semen Vignae Cylindricae 10-20 weight portion, Fructus Psoraleae 10-15 weight portion and Rhizoma Alpiniae Officinarum 5-15 weight portion.
Described medicine is formed and can also be preferably by the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portions, Flammulina velutipes 18 weight portions, Herba Dendrobii 21 weight portions, cutter ash tree 23 weight portions, Flos Lonicerae 26 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Flos Caryophylli 17 weight portions, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portions, Fructus Gymnocladi Chinensis 23 weight portions, Radix Kadsurae Coccineae 27 weight portions, 16 weight portions of delivering vegetables, Radix Paeoniae 18 weight portions, Nidus Vespae 23 weight portions, Bulbus Allii 10 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Pulvis Fumi Carbonisatus 27 weight portions, Fructus Setariae Germinatus 25 weight portions, Fructus Jujubae 20 weight portions, Semen Vignae Cylindricae 17 weight portions, Fructus Psoraleae 14 weight portions and Rhizoma Alpiniae Officinarum 8 weight portions.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the medicine of Gaster Sus domestica ulcer, described preparation method comprises the following steps: all crude drug are dropped into blender in proportion and stir 30～50 minutes, fully mix, pulverize; In the mixture after pulverizing, add the water with respect to 2～4 times of described mixture qualities, decoct 2～4 hours, filter, in filtering residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further with spray dryer, be dried and pulverize, sieve and obtain 50～100 order fine drug powders.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: with respect to the medicine that is used for the treatment of Gaster Sus domestica ulcer of the prior art, medicine of the present invention has evident in efficacy to Gaster Sus domestica ulcer treatment, and side effect is low, cure rate advantages of higher.
The specific embodiment
Chinese veterinarian thinks, Gaster Sus domestica ulcer is mainly due to due to stomach-QI being unable to descend normally " stagnation of QI and blood may bring about pain ".Sick position is at stomach, but dirty closely related with liver spleen two.Irritability is easily violated stomach gram spleen, and taste can involve mutually.How real liver is clinically, and how empty spleen is, the many qi depressions to blood stasis of stomach.During prescriptions, to treat flexibly according to the pathogenic characteristic of liver, spleen, stomach.Hyperactive liver-QI attacking the stomach person, should grasp the principle that " treating the liver can be pacified stomach " " avoids firm use soft ", accomplishes the soothing the liver stomach function regulating of not forgetting, the careful anti-impairment of YIN of regulating the flow of vital energy.Deficiency and coldness of spleen and stomach person, warming middle-JIAO and strengthening the spleen, should note crossing with the product with pungent fragrant warm-dryness syndrome of a specified duration." sour and sweet drugs can transforme into YIN " method is wanted for treatment deficiency of stomach-Yin is big, can not neglect.No matter be the peptic ulcer of which type gastric abscess, it, all can enter network for a long time, forms obstruction of collaterals by blood stasis, thus the Peptic Ulcers of prolonged illness, disperse blood stasis and dredge collateral, regulating QI to relieve pain can not be forgotten.The mechanism for the treatment of by Chinese herbs Gaster Sus domestica ulcer is, dispersing the stagnated liver-QI for regulating the stomach, invigorating the spleen and benefiting QI, blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, immunity and the gastrointestinal peristalsis ability of raising pig.
Based on above-mentioned theory of Chinese medical science, the invention provides a kind of medicine for the treatment of Gaster Sus domestica ulcer, comprise Radix Adenophorae (Radix Glehniae), Flammulina velutipes, Herba Dendrobii, cutter ash tree, Flos Lonicerae, Pericarpium Citri Reticulatae, Flos Caryophylli, Radix Ophiopogonis, Ipomoea batatas Lam., Fructus Gymnocladi Chinensis, Radix Kadsurae Coccineae, deliver vegetables, Radix Paeoniae, Nidus Vespae, Bulbus Allii, Endothelium Corneum Gigeriae Galli, Pulvis Fumi Carbonisatus, Fructus Setariae Germinatus and Fructus Jujubae.
Wherein, each crude drug pharmacology is as follows:
Radix Adenophorae (Radix Glehniae): sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, there is nourishing the lung to arrest cough, the effect of nourishing the stomach to promote the production of body fluid, the dry cough that is mainly used in thermal burn lung yin or lung-dryness syndrome due to deficiency of YIN is lacked expectorant, consumptive lung disease cough, the apoplexy due to phlegm blood streak, and calentura injures the withered symptoms such as thirsty and dry pharynx of stomach-Yin or prolonged illness deficiency of YIN Tianjin.
Flammulina velutipes: sweet; Salty; Cold in nature.Function cures mainly: tonifying liver; Benefit the intestines and stomach; Anticancer.Main hepatopathy; Gastrointestinal tract inflammation; Ulcer; Cancer.1. antitumor action: Flammulina velutipes Polysaccharides on Mice transplanted sarcoma S180, hepatocarcinoma H22 and Leuis pulmonary carcinoma all have obvious anti-tumor activity, its action intensity and krestin are close, Flammukinan has no obvious dose-effect relationship to the tumor-inhibiting action of murine sarcoma S180, may be because its effect is immunomodulating, but not direct killing oncocyte.It can suppress tumor growth, and neoplasm necrosis degree is increased, and glycogen content reduces, and the acid nonspecific esterase vigor of tumor tissues is declined.Mice lumbar injection every day Flammukinan 5mg/kg, continuous 10 days, the growth of the S180 solid tumor that can obviously suppress subcutaneous vaccination in Kunming mouse body, tumour inhibiting rate is 39.5%-40%.From Flammulina velutiper (Fr.) Sing, separation obtains polysaccharide PA3DE (relative molecular mass 540,000) and PA5DE (relative molecular mass 47.1 ten thousand) is respectively 50.2% and 46.7% to the suppression ratio of murine sarcoma S180.In addition, Flammukinan is carried out to separation and purification, also obtain EA3, EA5, tetra-components of EA6 and EA7, wherein EA3 and EA5 are respectively 82% and 84% to the suppression ratio of murine sarcoma S180.EA6 can strengthen the antineoplastic immune of leukemia L1210 vaccine to BDF1 mice, extends the life-span that inoculates 1000 leukemia L1210 cell mouse.Oral EA6 can strengthen generation and the delayed hypersensitivity reaction of the anti-sheep red blood cell (SRBC) of Sarcoma180 ICR mouse boosting cell (SRBC) antibody IgM, when with the same used time of tumor cryotherapy, the effect that this kind strengthens body fluid and cellular immunization is more showing, and can strengthen the effect of cryotherapy.But no matter separately oral or with the same use of cryotherapy, carbon is cleaned up experiment and is shown, EA6 can not strengthen mice reticuloendothelial system function.Separately from golden mushroom mycelium, separation obtains a kind of faintly acid containing 90% above protein, relative molecular mass is about 13000 glycoprotein (proflamin) the active anticancer showing, it has obvious effect to B-16 melanoma and adenocarcinoma 755, but do not have a cytotoxicity, oral this albumen of mice has no any obvious toxicity.In Flammulina velutiper (Fr.) Sing carpophore, contain a kind of proteoglycan, at 10mg/kg every day, under continuous 10 days dosage, it is 62.3% to the suppression ratio of murine sarcoma S180.2. the impact on immunologic function: Flammukinan 0.5-10 μ g/ml can show the normal rat spleen lymphocyte proliferation of promotion concanavalin A (Con A) induction and the generation of interleukin-2 (IL-2), but heavy dose of (50 μ g/ml) has inhibitory action to the generation of IL-2, Flammukinan also can resist the inhibitory action that immunosuppressant hydrocortisone produces IL-2, and the ability that makes suppressed lymphocyte produce IL-2 is partly recovered.3. antifatigue effect: the mice that takes Flammulina velutiper (Fr.) Sing certain hour, its Ldh Activity, muscle glycogen, hepatic glycogen content are all showing and are increasing, after swimming exercise, blood lactate level and serum urea nitrogen content obviously reduce, postexercise recovery phase blood lactic acid clearance rate is showing and is raising, show that Flammulina velutiper (Fr.) Sing has the adaptability of enhancing body sports load, the effect that resisting fatigue produces and accelerates elimination of fatigue.4. the impact on blood system: be separated to a kind of protease from Flammulina velutiper (Fr.) Sing, have in vivo and in vitro and suppress the effect that rat plasma condenses and promotes fibrinolytic, its effect is concentration and dose dependent.But during administration, can there is of short duration blood coagulation enhancing effect in vivo.5. antiinflammatory action: the Polysaccharides on Mice auricle inflammatory model extracting in golden mushroom mycelium, sporophore has antiinflammatory action, and its anti-inflammatory activity strengthens with the increase of relative molecular mass, and fruitbody polysaccharide anti-inflammatory activity is higher than mycelium polysaccharides.6. other effects: the blood fat rising that Flammulina velutiper (Fr.) Sing can prevent animal to cause because of feed high cholesterol diet, Flammulina velutiper (Fr.) Sing can also promote the synthetic of rat hemoglobin.7. toxicity: Flammulina velutiper (Fr.) Sing toxicity is minimum, the oral median lethal dose(LD 50) of rat and mice is all greater than 20g/kg, feeding is 7 days continuously, have no any toxic reaction, Salmonella reversion test is to TA97a, TA98, tetra-bacterial strain result of the tests of TA100 and TA102 are all negative, cytogenetics detects and does not find human peripheral blood lymphocytes to bring out chromosomal aberration effect, it is negative that sister chromosome monomer exchanges frequency, dosage 15g/kg is negative to rat bone marrow cell chromosomal aberration, dosage 5g/kg to the primary spermatocyte of mouse testis without bringing out chromosomal aberration effect.Rats gavaged golden needle fungus 0.01g/kg, 0.1g/kg, 1g/kg, 10g/kg, 6 dosage groups of 20g/kg and 30g/kg, feed 50 days continuously, and body weight is without rising appreciably, the heart, liver, spleen, lung, the equal no significant difference of kidney coefficient, each internal organs are compared equal to obvious pathological change with matched group through pathology section examination.
Herba Dendrobii: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For cloudy impairment of body fluid, lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.The newly organized > > of < < book on Chinese herbal medicine: Herba Dendrobii, sweet in the mouth, micro-hardship, cold nature is nontoxic.Unavailable bamboo dry measure used in former times, wooden dry measure used in former times, idle with it, Herba Dendrobii is frightened sedate, beneficial smart reinforcing YIN-essence, the outstanding power that can be good for foot knee joint, has been apt to numbness disease, falls the fire of the deficiency of YIN, has greatly distinguished service.Wu's purgation doctor, quite like with it, and people all over the world did not still know and knew its function this life.Lid Dendrobium nobile, is born among the grotto of Fujian, Guangdong, the ground of grotto and even the moon, and the side of Fujian, Guangdong Zhiyang is also, grasps Yinyang with life, thus cold not for cold, and impractical heat can be fallen.Husband's asthenic fire, also, Xiang Huoyi mends fire, and should not rush down mutually.Dendrobium nobile is wonderful is cold medicine, and has benefit, and its property is descending again, and not up.If fire easily rises mutually, and is difficult for the person of falling also, obtain Herba Dendrobii and fall and do not rise.Between Xia Yue, the unable persons of two foots, take Herba Dendrobii strong, Isn't that decline and hold concurrently and mend the bright of Zhiyin and test.Therefore with Cortex Phellodendri, Rhizoma Anemarrhenae reducing the minister-fire person, how about with Dendrobium nobile for working as.Lid Cortex Phellodendri, the Rhizoma Anemarrhenae is of no help in rushing down, and Dendrobium nobile invigorating middle warmer has and rushes down also.Or ask that the fire of the deficiency of YIN falls in Dendrobium nobile, be rush down the moon thing also, how can be good for the power of foot knee joint, wherein wonderful justice, not yet freely sends out.
Cutter ash tree: sweet; Property is put down.Hemostasia and promoting granulation; And liver spleen.Main traumatic hemorrhage; Spit blood; Spitting of blood; Furuncle; Infantile malnutrition; Eye conjunctivitis.
Flos Lonicerae: the loose poison of heat clearing away, < < Compendium of Materia Medica > > carries " Flos Lonicerae, is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, antipyretic, regulate the effect traditional Chinese medical science such as immunity to think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay the pathological changes effect of Respirovirus to cell, is the medicine that represents of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Flos Lonicerae preparation lumbar injection can obviously reduce the leukocyte count of rabbit due to the endotoxin of bacillus pyocyaneus and decline, and deviation to the left phenomenon etc. has obvious antagonism.Flos Lonicerae compatibility Radix Scutellariae is prepared into poisoning symptom and the death that preparation can obviously alleviate bacillus pyocyaneus endotoxin caused rabbit.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, for lung qi, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur.Be good at again drying dampness to eliminate phlegm, for controlling damp-phlegm, stop up the conventional key medicine of lung, abundant expectoration cough, for insufficiency of the spleen diet reduce, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea.Can spleen invigorating because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, Pericarpium Citri tangerinae again can with in, can control stomach-QI being unable to descend normally, nausea and vomiting.
Flos Caryophylli: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.< < Kaibao Bencao > >: " acrid in the mouth, temperature, nontoxic." enter stomach, spleen, kidney channel.< < Japan hanako materia medica > >: control implication, regurgitation, treats kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, warm waist knee joint, kills alcoholism, and the mass beside the umbilicus that disappears, except consumptive disease with cold nature.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, be slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.< < Mingyi Bielu > > records: treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, xerostomia excessive thirst, preventing or arresting vomiting is told, and more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted, protect god, determine lung qi, settling five organs, makes us fertile strong.The newly organized > > of < < book on Chinese herbal medicine records: Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, beneficial smart reinforcing YIN-essence, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often use less and can not be successfully for unfortunately also.Do not know that Radix Ophiopogonis is necessary multiplex, strength begins large, and Gai Huofu, in lung, sparkles dry interior liquid, and more than Radix Ophiopogonis, fire can not be made; Heat is vehement in stomach, endures its moon to the greatest extent, and more than Radix Ophiopogonis, fire can not cease.The fire that more has bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to the heat of bladder also, with the medicine of water flowing, do not imitate, with the agent of pathogenic fire reducing, do not imitate, how does this use again? the gas of lid bladder, must the clear respectful order of the part of the body cavity above the diaphragm housing the heart and lungs go, and fire is to decline, and water is lower logical.The clear respectful order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, heat of the lung, and making that lung is respectful is clearly not all right, and bladder fire closes, water also closes.Therefore wish is led to bladder person, gas that must lung heat clearing gold, the medicine of lung heat clearing is a lot of, all diminishes unhelpfully, if do not have benefit in clear Radix Ophiopogonis eventually, can rush down the fire of bladder, and don't damage the gas of bladder, yet use less it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and begin have Ji also.
Ipomoea batatas Lam.: invigorating middle warmer and blood; Supplementing QI for promoting the production of body fluid; Wide the intestines and stomach; Relieving constipation is secret.1. < < detailed outline is lifted and is lost > >: invigorating middle warmer, and blood, warming the stomach, fertile the five internal organs.Rhizoma Euonymus plain boiled pork person, lung benefiting gas promotes the production of body fluid.Jia Niujiang a slice while boiling, advises with Rhizoma Zingiberis Recens Fructus Jujubae is same in tune; (together) Flos Carthami is cooked, and can manage spleen blood, makes not leak.2. < < book on Chinese herbal medicine is asked former > >: removing heat from blood and promoting blood circulation, and wide the intestines and stomach, relieving constipation is secret, removes place stasis of blood dysentery, relaxing muscles and tendons network, hemostasis heat is thirsty, and puerpera is the most suitable.With fish, Channa argus food, tonify deficiency in tune.3. < < occupies diet spectrum > > with breath: the tonifying the spleen and stomach of cooking, physical strength profiting, imperial wind and cold, beneficial color.All sailing across a sea noted ship person, no matter raw ripe, lack of appetite is permitted i.e. peace.4. < < gathers medicinal herbs in the south of the Five Ridges and records > >: vinegar boils clothes, controls whole body swollen.
Fructus Gymnocladi Chinensis: pungent, temperature.Function cures mainly: except pertinacious phlegm, wash dirt greasy.Control cough expectorant stalk, dysentery, hemorrhoidal hamorrhage, inguinal bubo, head sore, scabies.1. < < detailed outline > >: curing rheumatism, dysentery, has blood in stool, skin ulcer, tinea, toxic swelling.2. in < <, traditional Chinese medicines are planted illustrated handbook > >: eliminate the phlegm.Control cough expectorant plug.
Radix Kadsurae Coccineae: pungent micro-hardship, temperature.Circulation of qi promoting, invigorates blood circulation, dissipating blood stasis, pain relieving.Control acute gastroenteritis, chronic gastritis, gastric and duodenal ulcers, rheumatic ostalgia, dysmenorrhes, puerperal, the stasis of blood was stagnant, traumatic injury, knife injury is hemorrhage.1. < < gathers medicinal herbs in the south of the Five Ridges and records > >: eliminating blood stasis to promote regeneration of blood.Control women through front and back belly pain, puerperal exposure to wind fan, cholera is vomited and diarrhoea and is knotted.2. < < Guangxi medicine is planted register > >: hemostasis, enrich blood.Control knife injury, uterine prolapse.3. the < < of Guangzhou army commonly uses Chinese herbal medicine handbook > >: promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, the detumescence of dispeling the wind.Control chronic gastritis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic ostalgia, traumatic injury paralysis pain, premenstrual abdominal pain, puerperal stasis of blood pain, edema.
Deliver vegetables: sweet in flavor and cold in property, nontoxic.Enter liver, kidney, urinary bladder channel.Can diuresis, heat clearing away, hard masses softening and resolving, the scale removal of reason intestinal, stagnant blood pressure lowering disappears.According to introduction in traditional Chinese medical science books, to deliver vegetables to thyromegaly, lymphoid tuberculosis, vitamin B1 deficiency, epistaxis, iron deficiency anemia, hypertension and gynaecopathia etc. have certain curative effect.The color of delivering vegetables is very black, plain, but the interior contained irony of delivering vegetables is higher, boils soup cook with delivering vegetables, and can enrich blood.Research is found, is delivered vegetables and also have ascarifuge, blood fat reducing function.It also has bowel relieving stomach, digestant effect.Patient after having an operation, eats of and delivers vegetables, and wound can comparatively fast heal.There is the disappear effect of stagnant, softening and eliminating sputum, the scale removal of reason intestinal of heat clearing away.Deliver vegetables and also there is blood pressure lowering.Regulating the multiple effects such as neural, is hypertension, coronary heart disease, high fat of blood patient's desirable food.Pharmaceutically purposes is very wide, and the conventional diseases such as rickets, gynaecological disease, dysentery, hypertension, tracheitis, epistaxis, malnutrition of delivering vegetables to treat among the people are especially edible after operation, to promoting that wound healing has special-effect.
Radix Paeoniae: bitter, sour, be slightly cold; Return liver, spleen channel.There is the effect of the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, suppressing liver-YANG.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Effect coronary artery dilator to cardiovascular system, reducing blood pressure, (d-cachou extract and progallin A have antithrombotic and antiplatelet aggregative activity; Liver protection effect has obvious protective effect to hepatic injury due to carbon tetrachloride, AFB1, D-galactosamine; Spasmolysis has inhibitory action to intestinal tube and stomach in place motion, significantly resists the uterine contraction that oxytocin causes; Analgesic activity can suppress mouse writhing, shouts, hot plate reaction, and morphine is suppressed to writhing response synergism, and can resist due to pentylenetetrazole and faint from fear.
Nidus Vespae: sweet, flat.Return stomach warp.Function cures mainly: dispels the wind, and merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.
Bulbus Allii: pungent, temperature.Function cures mainly: stomach invigorating, dysentery relieving, cough-relieving, sterilization, anthelmintic.Prevention influenza, epidemic cerebrospinal meningitis.Control pulmonary tuberculosis, pertussis, inappetence, dyspepsia, bacillary dysentery, amebic dysentery, enteritis, enterobiasis, ancylostomiasis; Trichomonas vaginitis is controlled in external, acute appendicitis.
Endothelium Corneum Gigeriae Galli: sweet, cold, return spleen, stomach, small intestinal, urinary bladder channel, for promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.
Pulvis Fumi Carbonisatus: pungent, temperature.Function cures mainly: hemostasis, antidiarrheal.For spitting blood, spitting of blood, has blood in stool, dysfunctional uterine hemorrhage, diarrhoea, food stagnation dysentery.Traumatic hemorrhage is controlled in external, epistaxis.
Fructus Setariae Germinatus: sweet, temperature.Return spleen, stomach warp.Function cures mainly: help digestion and in, spleen benefiting and stimulating the appetite.For food stagnation, do not disappear, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.The kind eliminate indigestion of Fructus Setariae Germinatus (parched to brown) is stagnant, for stagnant, does not disappear.
Fructus Jujubae: there is immunosuppressive action, the ethanol extract of Fructus Jujubae with every day 100mg to rat oral gavage, show that Fructus Jujubae and azathioprine have same immunosuppressant; To atopic diseases, can suppress the generation of antibody.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to other effects of inhibitory action: the two glucoside A of flavone in Fructus Jujubae, pharmacological evaluation proof has calmness, hypnosis and hypotensive effect, Fructus Jujubae to have the effect that increases cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to Rabbit Liver.Can extend the swimming time of mice.Report Fructus Jujubae has the proliferation function of anticancer recently.
In order to reach better therapeutic effect, formula of the present invention can also comprise: Semen Vignae Cylindricae, Fructus Psoraleae and Rhizoma Alpiniae Officinarum.
Semen Vignae Cylindricae: enter spleen, kidney channel.Function cures mainly: QI invigorating in tune, tonifying speen and tonifying kidney.1. < grandson < true man contraindication of food > >: " nephropathy should be eaten." 2. the Meng numerous: " tonifying five ZANG-organs, in tune, helps the twelve regular channels." 3. < < Japan hanako materia medica > >: " bean, warm the intestines and stomach.Leaf, sharp the five internal organs, the therapeutic method to keep the adverse QI flowing downwards."
Fructus Psoraleae: Fructus Psoraleae is returned kidney; The heart; Spleen; Stomach; Lung meridian.Show that according to the study Fructus Psoraleae stimulates keratinocyte to discharge inflammatory mediator, act on melanophore somatomedin, make remaining melanocyte proliferation in epidermis or hair follicle; Fructus Psoraleae acrid in the mouth; Bitter in the mouth; Warm in nature returning through kidney; Pericardium; Spleen; Stomach; Lung meridian function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Sexual impotence essence; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea.< < Bencao Jingshu > >: Fructus Psoraleae, energy warming the kidney; Raw sun in the moon, the key medicine of excessive fire benefit soil also.Its main five kinds of strain and seven kinds of impairment, the disease of lid edge impairment caused by overstrain, a lot of in asthenia of both the spleen and kidney, with its can warming the kidney, mend fire with the immature soil, being so incensed that to mend of kidney-Yang and rising in kidney, can digesting food, steam waste matter and change precise and tiny.On spleen-QI transporting the essence to the whole body, be attributed to lung, with honor, support the five internal organs, therefore the labor of main the five internal organs.Seven emotions hinder disease of viscera connecting with this channel.Wind cold caused by deficiency person, because yang-energy is decayed, and the air-cooled visitor that takes advantage of a weak point in opponent's defence so that bone marrow wound loses, the cold essence stream of kidney, and kidney governing bones store essential substances, marrow be essence this, the gas of kidney-Yang is solid, before card see, solid itself and yang-energy life, front card removes in vain.Man be take essence as main, and married woman be take blood as main, married woman vim and vigour person, and also still man's sun kidney that declines is cold and be the disease of blood prostration QI collapse caused by exhaustion of QI of the spleen and kidney, with man's the cold essence stream of kidney also.
Rhizoma Alpiniae Officinarum: hardship, cold.Function cures mainly: heat clearing away, regulate the flow of vital energy, and pain relieving.For acute gastroenteritis, dyspepsia, heatstroke stomachache, stomachache.
Embodiment 1 medicine 1
By Radix Adenophorae (Radix Glehniae) 28g, Flammulina velutipes 18g, Herba Dendrobii 21g, cutter ash tree 23g, Flos Lonicerae 26g, Pericarpium Citri Reticulatae 29g, Flos Caryophylli 17g, Radix Ophiopogonis 18g, Ipomoea batatas Lam. 21g, Fructus Gymnocladi Chinensis 23g, Radix Kadsurae Coccineae 27g, the 16g that delivers vegetables, Radix Paeoniae 18g, Nidus Vespae 23g, Bulbus Allii 10g, Endothelium Corneum Gigeriae Galli 27g, Pulvis Fumi Carbonisatus 27g, Fructus Setariae Germinatus 25g and Fructus Jujubae 20g drop into blender, stir 40 minutes, fully mix, pulverize; In the mixture after pulverizing, add the water with respect to 3 times of described mixture qualities, decoct 3 hours, filter, in filtering residue, add the water with respect to 2 times, described mixture again to decoct 1 hour, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further with spray dryer, be dried and pulverize, sieve and obtain 80 order fine drug powders.
Embodiment 2 medicines 2
By Radix Adenophorae (Radix Glehniae) 28g, Flammulina velutipes 18g, Herba Dendrobii 21g, cutter ash tree 23g, Flos Lonicerae 26g, Pericarpium Citri Reticulatae 29g, Flos Caryophylli 17g, Radix Ophiopogonis 18g, Ipomoea batatas Lam. 21g, Fructus Gymnocladi Chinensis 23g, Radix Kadsurae Coccineae 27g, the 16g that delivers vegetables, Radix Paeoniae 18g, Nidus Vespae 23g, Bulbus Allii 10g, Endothelium Corneum Gigeriae Galli 27g, Pulvis Fumi Carbonisatus 27g, Fructus Setariae Germinatus 25g, Fructus Jujubae 20g, Semen Vignae Cylindricae 17g, Fructus Psoraleae 14g and Rhizoma Alpiniae Officinarum 8g drop into blender, stir 50 minutes, fully mix, pulverize; In the mixture after pulverizing, add the water with respect to 4 times of described mixture qualities, decoct 3 hours, filter, in filtering residue, add the water with respect to 2 times, described mixture again to decoct 2 hours, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further with spray dryer, be dried and pulverize, sieve and obtain 100 order fine drug powders.
Toxicity test
Select SD rat, give the medicine dissolution liquid of the embodiment of the present invention 1 of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each is organized main organs histopathological examination and shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention, in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dosage safety of the clinical practice of the prompting embodiment of the present invention 1 medicine 1 is higher.To the medicine of the embodiment of the present invention 2, adopt identical test method to carry out toxicity test, prove that equally the dosage safety of clinical practice of the embodiment of the present invention 2 medicines 2 is higher.
Clinical trial
(1) laboratory animal
The phenomenon that pig sudden death appears in swinery is found to fatten in pig farm, Zibo City, Shandong Province in August, 2012, swinery is carried out to clinical examination, find that in swinery, inappetence, spirit difference many with vomiting phenomenon appear in some pig, there is before death discharging color of soy sauce loose stool in the pig that dies of illness, abnormal smells from the patient is stench, with vomiting and vomitus, mostly be the chyme that is mixed with blood, after dissecting, find that blood is thin, there is the circular or oval ulcer surface differing in size in stomach cardia district, it is brown that ulcer surface is, chap, stomach base area large-area hemorrhage.On inspection, there are 200 pigs nearly to suffer from gastric ulcer, select the ill pig of 162 body weight about 75kg experiment pig the most.
(2) test method
By 162 ill pigs, with entering to be divided into three experimental grouies, 54 every group, every group of average weight is 75kg.Three groups of medicine 1(embodiment groups 1 of using respectively the embodiment of the present invention 1), the medicine 2(embodiment group 2 of embodiment 2) and conventional medicament (matched group) treat.Embodiment 1 and 2 adds feedstuff by medicine 1 and medicine 2 according to the percentage by weight of feedstuff 3-8% respectively; Conventional medicament is sneaked into feedstuff after selecting bismuth subnitrate sheet to pulverize, and mixed volume is 1-3g/ head.Test period is 5-7 days.
(3) criterion of therapeutical effect
Effective: the treatment time limit is for mostly being most 5 days, and appetite, spirit and defecation etc. all recover normally, symptoms of emesis disappearance; Effective: the treatment time limit is 6 days or 7 days, and appetite takes a turn for the better to some extent, and mental restoration is normal, and feces is normal, without vomiting phenomenon; Invalid: inappetence, spirit is not improved, and still has vomiting phenomenon.
(4) therapeutic outcome
The results are shown in Table 1, from therapeutic effect, adopt medicine of the present invention to be 97.6% to the treated effect of Gaster Sus domestica ulcer, higher than matched group.
From the data of table 1, can find out: compare with matched group, use the Drug therapy Gaster Sus domestica ulcer of the embodiment of the present invention 1 and embodiment 2, there is short, the advantage such as therapeutic effect is good for the treatment of time.
Concrete case
Case 1
In July, 2012, there are 52 years old sows in Wu family due to the busy not free purchase perfect compound feed of housework, the Semen Maydis powder of only feeding, fed about two weeks, find that anemia, vomiting, inappetence and the low symptom of spirit all appear in 5 sows, and feces becomes Colophonium sample, wherein there is a sow to occur once in a while the phenomenon of spitting blood, be diagnosed as gastric ulcer.To the medicine that adds the embodiment of the present invention 1 of feedstuff gross weight 8% in feedstuff, to adhere to using 6 days, 5 sows all recover normally, and appetite and mental restoration are normal, and Anemia disappears.
Case 2
In July, 2011,121 growing and fattening pigs of Lee raiser, there is inappetence, the symptom that spirit is low in the pig of nearly 70, even has indivedual pig hematemesis, skin whitening, body temperature is normal, two pig death.Through censorship, finding, there is the circular or oval ulcer surface differing in size in the Gaster Sus domestica cardia district that dies of illness, and it is brown that ulcer surface is, and chaps, and stomach base area large-area hemorrhage, is diagnosed as gastric ulcer.To the medicine that adds the embodiment of the present invention 2 of feedstuff gross weight 5% in feedstuff, to adhere to using 5 days, 51 ill pigs all recover normal, appetite and mental restoration are normal, and Anemia disappears, and several ill pigs continue to use two days in addition, also all recover normal, transference cure.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. the medicine that is used for the treatment of Gaster Sus domestica ulcer, it is characterized in that, described medicine comprises following crude drug: Radix Adenophorae (Radix Glehniae), Flammulina velutipes, Herba Dendrobii, cutter ash tree, Flos Lonicerae, Pericarpium Citri Reticulatae, Flos Caryophylli, Radix Ophiopogonis, Ipomoea batatas Lam., Fructus Gymnocladi Chinensis, Radix Kadsurae Coccineae, deliver vegetables, Radix Paeoniae, Nidus Vespae, Bulbus Allii, Endothelium Corneum Gigeriae Galli, Pulvis Fumi Carbonisatus, Fructus Setariae Germinatus and Fructus Jujubae.
2. the medicine that is used for the treatment of Gaster Sus domestica ulcer according to claim 1, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, the 10-25 weight portion of delivering vegetables, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 15-25 weight portion.
3. the medicine that is used for the treatment of Gaster Sus domestica ulcer according to claim 1 and 2, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 25-30 weight portion, Flammulina velutipes 14-21 weight portion, Herba Dendrobii 18-23 weight portion, cutter ash tree 18-27 weight portion, Flos Lonicerae 22-31 weight portion, Pericarpium Citri Reticulatae 27-32 weight portion, Flos Caryophylli 14-21 weight portion, Radix Ophiopogonis 16-20 weight portion, Ipomoea batatas Lam. 18-23 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, the 13-20 weight portion of delivering vegetables, Radix Paeoniae 13-22 weight portion, Nidus Vespae 20-25 weight portion, Bulbus Allii 9-11 weight portion, Endothelium Corneum Gigeriae Galli 25-30 weight portion, Pulvis Fumi Carbonisatus 25-28 weight portion, Fructus Setariae Germinatus 20-30 weight portion and Fructus Jujubae 18-22 weight portion.
4. according to the medicine that is used for the treatment of Gaster Sus domestica ulcer described in claim 1-3 any one, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portions, Flammulina velutipes 18 weight portions, Herba Dendrobii 21 weight portions, cutter ash tree 23 weight portions, Flos Lonicerae 26 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Flos Caryophylli 17 weight portions, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portions, Fructus Gymnocladi Chinensis 23 weight portions, Radix Kadsurae Coccineae 27 weight portions, 16 weight portions of delivering vegetables, Radix Paeoniae 18 weight portions, Nidus Vespae 23 weight portions, Bulbus Allii 10 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Pulvis Fumi Carbonisatus 27 weight portions, Fructus Setariae Germinatus 25 weight portions and Fructus Jujubae 20 weight portions.
5. according to the medicine that is used for the treatment of Gaster Sus domestica ulcer described in claim 1-4 any one, it is characterized in that, described medicine also comprises: Semen Vignae Cylindricae, Fructus Psoraleae, Rhizoma Alpiniae Officinarum.
6. according to the medicine that is used for the treatment of Gaster Sus domestica ulcer described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 20-35 weight portion, Flammulina velutipes 10-25 weight portion, Herba Dendrobii 15-25 weight portion, cutter ash tree 15-30 weight portion, Flos Lonicerae 20-35 weight portion, Pericarpium Citri Reticulatae 20-35 weight portion, Flos Caryophylli 10-25 weight portion, Radix Ophiopogonis 10-22 weight portion, Ipomoea batatas Lam. 15-25 weight portion, Fructus Gymnocladi Chinensis 20-25 weight portion, Radix Kadsurae Coccineae 25-30 weight portion, the 10-25 weight portion of delivering vegetables, Radix Paeoniae 10-25 weight portion, Nidus Vespae 15-25 weight portion, Bulbus Allii 8-12 weight portion, Endothelium Corneum Gigeriae Galli 22-33 weight portion, Pulvis Fumi Carbonisatus 22-30 weight portion, Fructus Setariae Germinatus 20-30 weight portion, Fructus Jujubae 15-25 weight portion, Semen Vignae Cylindricae 10-20 weight portion, Fructus Psoraleae 10-15 weight portion and Rhizoma Alpiniae Officinarum 5-15 weight portion.
7. according to the medicine that is used for the treatment of Gaster Sus domestica ulcer described in claim 1-6 any one, it is characterized in that, described medicine is comprised of the crude drug of following parts by weight: Radix Adenophorae (Radix Glehniae) 28 weight portions, Flammulina velutipes 18 weight portions, Herba Dendrobii 21 weight portions, cutter ash tree 23 weight portions, Flos Lonicerae 26 weight portions, Pericarpium Citri Reticulatae 29 weight portions, Flos Caryophylli 17 weight portions, Radix Ophiopogonis 18 weight portion, Ipomoea batatas Lam. 21 weight portions, Fructus Gymnocladi Chinensis 23 weight portions, Radix Kadsurae Coccineae 27 weight portions, 16 weight portions of delivering vegetables, Radix Paeoniae 18 weight portions, Nidus Vespae 23 weight portions, Bulbus Allii 10 weight portions, Endothelium Corneum Gigeriae Galli 27 weight portions, Pulvis Fumi Carbonisatus 27 weight portions, Fructus Setariae Germinatus 25 weight portions, Fructus Jujubae 20 weight portions, Semen Vignae Cylindricae 17 weight portions, Fructus Psoraleae 14 weight portions and Rhizoma Alpiniae Officinarum 8 weight portions.
8. according to the preparation method of the medicine that is used for the treatment of Gaster Sus domestica ulcer described in claim 1-7 any one, it is characterized in that, described preparation method comprises the following steps: all crude drug are dropped into blender in proportion and stir 30～50 minutes, fully mix, pulverize; In the mixture after pulverizing, add the water with respect to 2～4 times of described mixture qualities, decoct 2～4 hours, filter, in filtering residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further with spray dryer, be dried and pulverize, sieve and obtain 50～100 order fine drug powders.
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| CN107596330A (en) * | 2017-10-29 | 2018-01-19 | 石阡裕和原生态农牧发展有限公司 | A kind of Chinese medicine composition for treating swine gastric ulcer and preparation method thereof |
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| CN103610991B (en) | 2015-08-12 |
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