CN103609853B - Feed for treating swine gastric ulcer and preparation method thereof - Google Patents
Feed for treating swine gastric ulcer and preparation method thereof Download PDFInfo
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- CN103609853B CN103609853B CN201310672138.1A CN201310672138A CN103609853B CN 103609853 B CN103609853 B CN 103609853B CN 201310672138 A CN201310672138 A CN 201310672138A CN 103609853 B CN103609853 B CN 103609853B
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Abstract
The invention discloses feed for treating swine gastric ulcer and a preparation method thereof. The feed is prepared from the following raw materials: corns, bean pulps, spinach powder, pumpkin powder, winter mushroom powder, an antioxidant and a traditional Chinese medicine additive. The feed disclosed by the invention has the beneficial effects that the feed contains the traditional Chinese medicine additive for treating swine gastric ulcer; the traditional Chinese medicine additive is matched with other raw materials of the feed, so that the feed for treating swine gastric ulcer has the advantages of remarkable curative effect, low side effect and high cure rate.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of feed being used for the treatment of swine gastric ulcer and preparation method thereof.
Background technology
Gastric ulcer refers in particular to the oesophagus district ulcer of stomach.In recent years, common in the slaughter pig in slaughterhouse; In daily aquaculture management, also once ran into many cases, be wherein the subject matter causing pig farm pig death several times.Gastric ulcer is mainly limited to the oesophagus district of stomach, and sick just visible mucomembranous surface corrugates, and becomes coarse, is very easily dyed Huang, yellowish-brown or green by bile or gastric content; And then mucous epithelium is destroyed, formed rotten to the corn, uneven; Finally form ulcer, hemorrhage.Oesophagus district depression time serious, marginal swell becomes dike shape.The stomach of gastric ulcer expands more, follows the string in oesophagus district; Gastric content is soft or aqueous; It is yellowish-brown when having hemorrhage; It is then soy sauce sample during severe haemorrhage.In diagnosed case, it is reported, being bred as group is owing to feeding particulate material; A group big porker is due to quick growth, and the main super several times amount of poultry has fed copper sulphate; High-temperature sterilization defatted milk is fed in one piglet field.Wherein feed the field of particulate material, gastrorrhagia, ulcer especially severe, tell chocolate stomach content before death, is coal tar oil sample thing after cuing open inspection in little intestinal content and stomach.In addition, the reason that document is recorded also has and lacks selenium and vitamin E, treats that government official's time is long, crowded, nervous etc. before government official.1. 1. feed quality is not good for feed, and feed is coarse, mouldly loses, and is difficult to digestion, lacks nutrition; 2. a large amount of irritating mineral matter mixture is mixed in daily ration; 3. enough fibers are lacked in daily ration; 4. the ratio containing corn in grain ration is too high, then its incidence of disease is also higher; No matter corn is through fine grinding, expansion or gel, and its incidence of disease still has higher tendency.2. this disease of stress factor is mainly in stable breeding pig, especially accepts a large amount of cereal and grows fast pig.Often being vulnerable to the stress such as overcrowding, excessively agitation, just before giving birth front miscarriage causes neurohumor regulative mechanism disorderly.3. this disease of inherent cause has very large heredity, grows pig that is fast and that carry on the back fat few relevant with seed selection.4. secondary factor swine fever, chronic brickpox, ascaris suum infection, copper poisoning liver malnutrition, mulberries sample heart disease etc., cause gastric mucosa congestion, hemorrhage, rotten to the corn, ulcer, thus Secondary cases gastric ulcer occurs.Only have according to symptom and cut open inspection diagnosis.Diagnosis can according to the characteristic sum symptom having hemorrhagic anemia, and pathology cuts open inspection and sees extensive bleeding in stomach, and the dry ight soil of row's black, and specific apparatus inspection, make diagnosis as endoscopy, hematological examination and stool examination.
Symptom: the 1. acute clinical symptom pig that loses is dead.Die from stomach lining hemorrhage more.Cut open new blood in the common stomach of inspection.2. subacute disease pig has significantly pale, Anemia, weak, apocleisis and accelerated breathing, ight soil becomes from the sticky pasty state of black the bead being coated with mucus on a small quantity, sickly just to suffer from abdominal pain, grinds one's teeth in sleep, uneasy, sometimes occur vomiting, have blood in stool, just dry be its common characteristic symptom.Do not rise sleepingly, how weak dead at 12 ~ 48h.3. chronic disease pig is due to Anemia of losing blood, ochrodermia, and ight soil turns black.The symptom of the chronic peritonitis that occurs together had.Cut open inspection and can see the excessive keratinization of stomach lining and epithelium strips off, have without real ulcer, but in stomach, had the aqueous content of volume.The sick stomach dye had has bile.
Current prophylactico-therapeutic measures: grain trough does not store too of a specified duration, from fungal contamination, because mould can make unsaturated fatty acid content increase, thus easily sends out gastric ulcer.Cause as being that copper is excessive, the zinc carbonate of available 110ppm is as feed addictive.(1) principle for the treatment of treatment is sedation-analgesia, antiacid only ferment, anti-inflammation hemostasia, improves raising, intensive care simultaneously.Improve and raise, be rich in the digestible feed of nutrition, reduce stress reaction.Ease the pain and reflectivity stimulation.Oral tannic acid protection stomach lining, with in the antiacids such as magnesia and hydrochloric acid in gastric juice, throws and takes bismuth subnitrate 2 ~ 6g and protect ulcer surface, prevent hemorrhage, Promotive union.(2) prevent prevention can strengthen feeding and management, provide complete feed, it is meticulous or excessively thick by fodder crushing to avoid, reduce various stress.
The side effect of Western medicine is larger, and, Western medicine only has obvious curative effect to single illness or a class illness when treating, for the disease that some illnesss are more, curative effect may be just not too obvious, usually need out a lot of Western medicine, and, Western medicine is synthesis, price can be China's traditional medicine than a lot of Chinese herbal medicines of Chinese herbal medicine and Chinese patent drug costliness naturally, for chemical synthetic drug, Chinese herbal medicine has plurality of active ingredients, not only there is toxicity low, not easily have side effects, but, at present, be used for the treatment of the feed of swine plague and the result for the treatment of of relevant Chinese herb feed additive and not satisfactory.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed being used for the treatment of swine gastric ulcer and preparation method thereof, adopt this feed to swine gastric ulcer treatment have efficient, toxic and side effect is little, noresidue, do not develop immunity to drugs, not contaminated air, short treating period and the not easily advantage such as recurrence.
In order to realize foregoing invention object, the invention provides a kind of feed being used for the treatment of swine gastric ulcer, described feed comprises following raw material: corn, dregs of beans, spinach powder, pumpkin powder, dried mushroom powder, antioxidant and Chinese medicine additive.
Described feed is made up of the raw material of following parts by weight: corn 60-80 weight portion, dregs of beans 40-60 weight portion, spinach powder 20-40 weight portion, pumpkin powder 20-40 weight portion, dried mushroom powder 20-50 weight portion, antioxidant 5-15 weight portion and Chinese medicine additive 5-20 weight portion.
Described feed forms preferably by the raw material of following parts by weight: corn 70 weight portion, dregs of beans 50 weight portion, spinach powder 30 weight portion, pumpkin powder 30 weight portion, dried mushroom powder 40 weight portion, antioxidant 9 weight portion and Chinese medicine additive 12 weight portion.
Described Chinese medicine additive comprises following bulk drug: the root of straight ladybell, the stem of noble dendrobium, cutter ash tree, honeysuckle, dried orange peel, cloves, the tuber of dwarf lilyturf, sweet potato, Chinese coffeetree fruit, scarlet kadsura root, deliver vegetables, Chinese herbaceous peony, honeycomb, garlic, the membrane of a chicken's gizzard, Plant Soot, rice sprout and date.
Described Chinese medicine additive forms preferably by the bulk drug of following parts by weight: the root of straight ladybell 20-35 weight portion, stem of noble dendrobium 15-25 weight portion, cutter ash tree 15-30 weight portion, honeysuckle 20-35 weight portion, dried orange peel 20-35 weight portion, cloves 10-25 weight portion, the tuber of dwarf lilyturf 10-22 weight portion, sweet potato 15-25 weight portion, Chinese coffeetree fruit 20-25 weight portion, scarlet kadsura root 25-30 weight portion, to deliver vegetables 10-25 weight portion, Chinese herbaceous peony 10-25 weight portion, honeycomb 15-25 weight portion, garlic 8-12 weight portion, the membrane of a chicken's gizzard 22-33 weight portion, Plant Soot 22-30 weight portion, rice sprout 20-30 weight portion, date 15-25 weight portion, white peas or beans 10-20 weight portion, Psoralea corylifolia 10-15 weight portion and galingal 5-15 weight portion.
Described Chinese medicine additive forms preferably by the bulk drug of following parts by weight: the root of straight ladybell 28 weight portion, the stem of noble dendrobium 21 weight portion, cutter ash tree 23 weight portion, honeysuckle 26 weight portion, dried orange peel 29 weight portion, cloves 17 weight portion, the tuber of dwarf lilyturf 18 weight portion, sweet potato 21 weight portion, Chinese coffeetree fruit 23 weight portion, scarlet kadsura root 27 weight portion, to deliver vegetables 16 weight portions, Chinese herbaceous peony 18 weight portion, honeycomb 23 weight portion, garlic 10 weight portion, the membrane of a chicken's gizzard 27 weight portion, Plant Soot 27 weight portion, rice sprout 25 weight portion, date 20 weight portion, white peas or beans 17 weight portion, Psoralea corylifolia 14 weight portion and galingal 8 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps: all bulk drugs are dropped in proportion mixer and stir 30 ~ 50 minutes, fully mix, pulverize; The water relative to described mixture quality 2 ~ 4 times is added in the mixture after pulverizing, decoct 2 ~ 4 hours, filter, add in filter residue and again decoct 1 ~ 2 hour relative to the water of 1 ~ 2 times, described mixture, filter, by twice filtrate mixing, reduced pressure concentration removing moisture, obtain dry lotion, dry with spray dryer further and pulverize, sieve acquisition 50 ~ 100 order Chinese medicine additive fine powder.
Described antioxidant is one or more in vitamin E, vitamin C, zinc methionine, chromium picolinate, yeast selenium, zinc sulfate, magnesium sulfate.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the feed of swine gastric ulcer, described preparation method comprises the following steps:
The first step, the preparation of described Chinese medicine additive;
Second step, is ground into 100 order ~ 200 object powder after corn, dregs of beans, spinach powder, pumpkin powder and dried mushroom powder being mixed, ferments 7 days, and controlled by fermentation temperature at 120 ~ 130 DEG C; Powder is broken into after drying at 50 ~ 80 DEG C after fermenting, the Chinese medicine additive fine powder obtained with the first step and antioxidant mix, pour into and be placed in the granulating disc of heeling condition, opening granulating disc makes it rotate, the rotating speed of granulating disc is 50 revs/min, preparation time is 15 minutes, is prepared into the spherical particle feed that diameter is 1 millimeter;
3rd step, by the spherical particle feed that second step obtains, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, import air temperature of heating is 150 degree, and outlet air temperature is 80 degree, obtains dry feed granules.
Wherein, the preparation method of described first step Chinese medicine additive is: all bulk drugs are dropped in proportion mixer and stir 30 ~ 50 minutes, fully mix, pulverize; The water relative to described mixture quality 2 ~ 4 times is added in the mixture after pulverizing, decoct 2 ~ 4 hours, filter, add in filter residue and again decoct 1 ~ 2 hour relative to the water of 1 ~ 2 times, described mixture, filter, by twice filtrate mixing, reduced pressure concentration removing moisture, obtain dry lotion, dry with spray dryer further and pulverize, sieve acquisition 50 ~ 100 order Chinese medicine additive fine powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains the Chinese medicine additive for the treatment of swine gastric ulcer, Chinese medicine additive and other raw materials of feed are worked in coordination, have evident in efficacy to swine gastric ulcer treatment, side effect is low, the advantage that cure rate is high.
Detailed description of the invention
Chinese veterinarian thinks, swine gastric ulcer is mainly due to caused by stomach Qi rising " stagnation of QI and blood may bring about pain ".Sick position is at stomach, but dirty closely related with liver spleen two.Irritability easily violates stomach gram spleen, and taste can involve mutually.How real liver is clinically, and how empty spleen is, the many qi depressions to blood stasis of stomach.To treat flexibly according to the pathogenic characteristic of liver, spleen, stomach during prescriptions.Liver-qi attacking stomach person, should grasp the principle of " control liver and can pacify stomach " " avoid just with soft ", accomplishes soothing the liverly not forget and stomach, careful anti-impairment of yin of regulating the flow of vital energy.Deficiency-cold in spleen and stomach person, warming middle-JIAO and strengthening the spleen, should note should not crossing with the product dry by pungent fragrant temperature of a specified duration." sour-sweet herbs nourishing yin " method is wanted for treatment deficiency of stomach-Yin is big, can not neglect.Be no matter the peptic ulcer of which type epigastric pain, it, all can enter network for a long time, forms obstruction of collaterals by blood stasis, therefore the canker of prolonged illness, disperse blood stasis and dredge collateral, regulating qi-flowing for relieving pain can not be forgotten.The mechanism for the treatment of by Chinese herbs swine gastric ulcer is, soothing liver and harmonizing stomach, and strengthening the spleen and replenishing qi is promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain, improves immunity and the gastrointestinal peristalsis ability of pig.
Based on above-mentioned theory of traditional Chinese medical science, the invention provides a kind of feed for the treatment of swine gastric ulcer, wherein feed comprises Chinese medicine additive, Chinese medicine additive comprises the root of straight ladybell, the stem of noble dendrobium, cutter ash tree, honeysuckle, dried orange peel, cloves, the tuber of dwarf lilyturf, sweet potato, Chinese coffeetree fruit, scarlet kadsura root, delivers vegetables, Chinese herbaceous peony, honeycomb, garlic, the membrane of a chicken's gizzard, Plant Soot, rice sprout and date.
Wherein, each bulk drug pharmacology is as follows:
The root of straight ladybell: sweet, the micro-hardship of taste, cold nature, enters lung, stomach warp, moisten the lung and relieve the cough, the effect of nourishing the stomach to improve the production of body fluid, is mainly used in the few phlegm of dry cough of thermal burn lung yin or the lung-dryness syndrome due to yin deficiency, consumptive lung disease is coughed, the trace of blood in phlegm, and pyreticosis injures the symptoms such as the withered thirsty and dry pharynx of stomach-Yin or prolonged illness deficiency of Yin Tianjin.
The stem of noble dendrobium: reinforcing stomach reg fluid is nourishing Yin and clearing heat.Hinder body fluid deficiency for the moon, dry polydipsia, food is few retches, and abnormal heat after being ill, order is secretly failed to understand." book on Chinese herbal medicine is newly organized ": the stem of noble dendrobium, sweet, the micro-hardship of taste, cold nature is nontoxic.Unavailable bamboo dry measure used in former times, wooden dry measure used in former times, idle with it, the stem of noble dendrobium is frightened sedate, and beneficial smart reinforcing yin essence can be good for the power of pin knee especially, has been apt to numbness disease, has fallen the fire of the deficiency of Yin, have distinguished service greatly.Doctor under this life Wu, quite likes with it, and people all over the world does not still know and knows its function.Lid HERBA DENDROBII, be born among the grotto of Fujian, Guangdong, the ground of grotto and even the moon, and the side of Fujian, Guangdong Zhiyang is also, grasps Yinyang with life, thus cold be not cold, and impractical heat can be fallen.Husband's fire of deficiency type, Xiang Huoye, Xiang Huoyi mend, and should not rush down.HERBA DENDROBII is wonderful is cold medicine, and has benefit, and its property is descending again, and not up.If fire mutually, easily rises, and does not easily fall person also, obtain the stem of noble dendrobium and then fall and do not rise.Between Xia Yue, the unable persons of two foots, take the stem of noble dendrobium then strong, Isn't that decline and hold concurrently and mend the bright of Zhiyin and test.Therefore with golden cypress, wind-weed reducing the minister-fire person, how about with HERBA DENDROBII for working as.Lid golden cypress, the wind-weed are of no help in rushing down, and HERBA DENDROBII bowl spares has and rushes down also.Or ask that the fire of the deficiency of Yin falls in HERBA DENDROBII, be rush down the moon thing also, how can be good for the power of pin knee, wherein wonderful justice, not yet freely sends out.
Cutter ash tree: sweet; Property is put down.Hemostasia and promoting granulation; And liver spleen.Main traumatism and bleeding; Spit blood; Spitting of blood; Sore furuncle; Infantile malnutrition due to digestive disturbances or intestinalparasites; Eye conjunctivitis.
Honeysuckle: the loose poison of heat-clearing, Compendium of Material Medica is carried " honeysuckle, being good at poison, therefore control ulcer, pyogenic infections, sore tinea ... ".Since ancient times, honeysuckle is usually used in clearing heat and detoxicating, the heating for the treatment of warm disease, toxic-heat and blood stasis, the diseases such as large carbuncle.Modern pharmacological research shows, honeysuckle has the effect traditional Chinese medical science such as antibacterial, antiviral, anti-inflammatory, antipyretic, immunity moderation and thinks, honeysuckle is cold in nature, taste is sweet, gas is flat, has clearing heat and detoxicating effect, can treat the diseases such as hot malicious early stage of pyogenic infection of skin, ulcer furunculosis.And have the loose effect of a surname concurrently.Honeysuckle antipyretic and antidote functions is quite strong.Honeysuckle can delay the pathology effect of Respirovirus to cell, is clearing heat and detoxicating representative medicine, and hot malicious essence is except containing multiple pathogenic microorganisms, and microbial toxin also accounts for critical positions.Caused by the endotoxin that honeysuckle preparation lumbar injection obviously can reduce Pseudomonas aeruginosa, the leukocyte count of rabbit declines, and deviation to the left phenomenon etc. has obvious antagonism.The honeysuckle compatibility root of large-flowered skullcap is prepared into poisoning symptom and the death that preparation obviously can alleviate Pseudomonas aeruginosa endotoxin caused rabbit.
Dried orange peel: warm in nature, taste is pungent, bitter; Return spleen, lung channel, for diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, gather around the diseases such as stagnant, chest diaphragm ruffian full and the taste stagnation of the circulation of vital energy, abdominal fullness and distention for lung qi, for damp retention in middle-jiao, gastral cavity abdomen ruffian is swollen, have loose bowels in loose stool, and the disease such as many coughs of phlegm.Orange peel dispelling dampness with bitter and warm-natured drugs and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy.Being good at again eliminating dampness and eliminating phlegm, stopping up the conventional key medicine of lung, the many coughs of phlegm for controlling wet phlegm, reduce for insufficiency of the spleen diet, indigestion, and the disease such as n and V.This product eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizing, indigestion, stool diarrhea.Because it can invigorating the spleen, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, orange peel again can with in, stomach Qi rising, n and V can be controlled.
Cloves: Wen Zhong, warm kidney, fall inverse.Cure mainly: control hiccup, vomiting, gastric disorder causing nausea, dysentery, trusted subordinate's crymodynia, Xuan addiction, hernia, ringworm." Kaibao Bencao ": " taste is pungent, temperature, nontoxic." enter stomach, spleen, kidney channel." Japan hanako materia medica ": control implication, gastric disorder causing nausea, treats kidney qi, up-rushing gas syndrome, cloudy pain, establishing-Yang, and warm waist knee, kill wine poison, disappear Xuan addiction, except cold labor.
The tuber of dwarf lilyturf: sweet, the micro-hardship of taste, is slightly cold.The thoughts of returning home, lung, stomach warp.Function with cure mainly: nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough, deficiency of Yin consumptive disease is coughed, larynx numbness pharyngalgia, and Tianjin wound is thirsty, and interior heat is quenched one's thirst, vexed insomnia, the dry constipation of intestines." Mingyi Bielu " is recorded: treat the heavy order of body yellow, rami cardiaci inferiores is full, consumptive disease visitor heat, dry polydipsia, anti-nausea, and more impotence falls, reinforcing yin essence benefit essence, and disappear Gu Tiaozhong, protects god, determine lung qi, five viscera settling, makes us fertile strong." book on Chinese herbal medicine is newly organized " is recorded: the tuber of dwarf lilyturf, the volt fire in purging the lung of pathogenic fire, the heat evil in clearing stomach, the internal lesion caused by overexertion of bushing gas, the vomiting of hemostasis man, the smart reinforcing yin essence of benefit, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, and what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown tuber of dwarf lilyturf, often few use and can not be successfully unfortunate also.Do not know that the tuber of dwarf lilyturf must be multiplex, strength begins large, and Gai Huofu is in lung, and sparkle liquid in doing, more than the tuber of dwarf lilyturf, then fire can not be made; Heat is vehement in stomach, and endure its moon to the greatest extent, more than the tuber of dwarf lilyturf, then fire can not cease.More have the fire of bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to bladder heat also, do not imitate with the medicine of water flowing, do not imitate with the agent of falling fire, this again what with? the gas of lid bladder, must the respectful clearly order row of the part of the body cavity above the diaphragm housing the heart and lungs, and fire is decline, and water is lower logical.The respectful clearly order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, and heat of the lung,retention of pathogenic heat in the lung, then making that lung is respectful is clearly not all right, and bladder fire closes, and water also closes.Therefore for logical bladder person, must the gas of clearing lung-heat gold, the medicine of clearing lung-heat is a lot of, all damages unhelpful, if eventually not the tuber of dwarf lilyturf clear in have benefit, the fire of bladder can be rushed down, and don't damage the gas of bladder, but few with it, also can not be successful, the lid smell tuber of dwarf lilyturf is flat cold, must be multiplex and the beginning has Ji also.
Sweet potato: bowl spares and blood; Nourishing generate fluid; Wide stomach; Defaecation is secret.1. " detailed outline lifts something lost ": bowl spares, and blood, warm stomach, fertile the five internal organs.White skin plain boiled pork person, beneficial lung qi promotes the production of body fluid.Jia Niujiang a slice when boiling, advises together with ginger jujube in tune; (together) safflower is cooked, and can manage spleen blood, makes not leak.2. " book on Chinese herbal medicine asks former ": cooling and activating blood, wide stomach, defaecation is secret, removes place stasis of blood dysentery, relaxing muscles and tendons network, and hemostasis heat is thirsty, and puerpera is the most suitable.With fish, murrel fish food, qi-restoratives in tune.3. " occupy diet spectrum with breath ": tonifying spleen and stomach of cooking, beneficial strength, imperial chill, beneficial color.All note ship persons that sails across a sea, no matter raw ripe, namely food pacifies a little.4. " south of the Five Ridges gather medicinal herbs record ": vinegar boils clothes, control whole body to swell.
Chinese coffeetree fruit: pungent, temperature.Function cures mainly: except stupid phlegm, washs dirt greasy.Control cough phlegm stalk, dysentery, intestines wind, bubo, head sore, mange.1. " detailed outline ": curing rheumatism, diarrhea, has blood in stool, sore, tinea, pyogenic infections.2. " illustrated handbook planted by middle traditional Chinese medicines ": eliminate the phlegm.Control cough phlegm plug.
Scarlet kadsura root: pungent micro-hardship, temperature.Promoting the circulation of qi, invigorates blood circulation, the loose stasis of blood, pain relieving.Control acute gastroenteritis, chronic gastritis, gastric and duodenal ulcer, treating rheumatic ostealgia, dysmenorrhes, postpartum, the stasis of blood was stagnant, traumatic injury, and knife wound is hemorrhage.1. " south of the Five Ridges gather medicinal herbs record ": eliminate blood stasis and promote tissue regeneration.Control women through front and back collywobbles, cold after delivery fan, cholera is vomited and diarrhoea and is knotted.2. " register planted by Guangxi medicine ": hemostasis, enrich blood.Control knife wound, the prolapse of uterus.3. Guangzhou army " conventional Chinese herbal medicine handbook ": promoting qi circulation and relieving pain, promoting blood circulation to remove blood stasis, detumescence of dispeling the wind.Control chronic gastritis, acute gastroenteritis, gastric and duodenal ulcer, treating rheumatic ostealgia, fall beat paralysis pain, premenstrual abdominal pain, postpartum the stasis of blood pain, edema.
Deliver vegetables: sweet in flavor and cold in property, nontoxic.Enter liver, kidney, urinary bladder channel.Can diuresis, heat-clearing, softening and resolving hard mass, the scale removal of reason intestines, disappear stagnant step-down.According to introduction in traditional Chinese medical science books, deliver vegetables to Thyroid Gland Swell, scrofula, athlete's foot, nosebleed, hypoferric anemia, hypertension and gynaecological disease etc. have certain curative effect.The color of delivering vegetables is very black, plain, but interior contained irony of delivering vegetables is higher, boiling soup and cooking, can enrich blood with delivering vegetables.Research finds, delivers vegetables and also has ascarifuge, blood fat reducing function.It also has gut purge stomach, digestant effect.Patient after having an operation, eats of and delivers vegetables, and wound can comparatively fast heal.There is heat-clearing to disappear effect of stagnant, softening and eliminating sputum, the scale removal of reason intestines.Delivering vegetables, it is hypotensive also to have.Regulating the multiple effects such as neural, is hypertension, the desirable food of coronary heart disease, high fat of blood patient.Pharmaceutically purposes is very wide, and among the people commonly using delivers vegetables to treat the diseases such as rickets, gynaecological disease, dysentery, hypertension, tracheitis, nosebleed, malnutrition, and especially Post operation eats, and has special-effect to promotion wound healing.
Chinese herbaceous peony: bitter, sour, is slightly cold; Return liver, the spleen channel.There is the effect of the astringe yin that nourishes blood, easing the affected liver to relieve pain, suppressing liver-YANG.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band.To the effect coronary artery dilator of cardiovascular system, reducing blood pressure, (d-cachou extract and progallin A have antithrombotic and antiplatelet aggregative activity; Liver protection effect has obvious protective effect to hepatic injury caused by carbon tetrachloride, AFB1, D-galactosamine; Spasmolysis has inhibitory action to intestinal tube and stomach in place motion, significantly resists the uterine contractile that oxytocins causes; Analgesic activity can suppress mouse writhing, shouts, hot plate reaction, suppresses writhing response to have synergy to morphine, and can resist that pentylenetetrazole is caused faints from fear.
Honeycomb: sweet is flat.Return stomach warp.Function cures mainly: dispel the wind, merit poison, desinsection, pain relieving.For dental caries and toothache, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, the fungal infection of the hand.
Garlic: pungent, temperature.Function cures mainly: stomach invigorating, only dysentery, cough-relieving, sterilization, expelling parasite.Prevention influenza, meningococal meningitis.Control pulmonary tuberculosis, pertussis, poor appetite, indigestion, bacillary dysentery, amoebic dysentery, enteritis, enterobiasis, hookworm disease; Trichomonas vaginalis is controlled in external application, acute appendicitis.
The membrane of a chicken's gizzard: sweet, cold, return spleen, stomach, small intestine, urinary bladder channel, for food digesting stomach fortifying, arresting seminal emission.The membrane of a chicken's gizzard is containing gastric hormone, keratin, amino acid and micro-pepsin, amylase etc.After oral the membrane of a chicken's gizzard powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extractants liquid or decoction can accelerate to get rid of radiostrontium from urine.
Plant Soot: pungent, temperature.Function cures mainly: hemostasis, antidiarrheal.For spitting blood, spitting of blood, has blood in stool, functional uterine bleeding, and diarrhoea, dyspepsia rushes down dysentery.Traumatism and bleeding is controlled in external application, bleeding from five sense organs or subcutaneous tissue.
Rice sprout: sweet, temperature.Return spleen, stomach warp.Function cures mainly: help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for dyspepsia, abdominal distension halitosis, weakness of the spleen and the stomach, not hungry food is few.Fry rice sprout relatively to help digestion, few for not hungry food.It is stagnant that burnt rice sprout is apt to eliminate indigestion, do not disappear for stagnant.
Date: there is immunosuppressive action, the alcohol extract of date with every day 100mg to rat oral gavage, display date has same immunosupress with imuran; The generation of antibody can be suppressed to atopic diseases.Date alcohol extract may have inhibitory action to rat reactive antibody, and other effects of inhibitory action are not produced to non-reacted antibody: the two glucoside A of the flavones in date, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and date has the effect increasing cAMP in white blood cell.Date decoction can reduce the damage of CCl4 to Rabbit Liver.The swimming time of mouse can be extended.Nearest report date has the proliferation function of inhibition cancer cell.
In order to reach better result for the treatment of, formula of the present invention can also comprise: white peas or beans, Psoralea corylifolia and galingal.
White peas or beans: enter spleen, kidney channel.Function cures mainly: beneficial gas in tune, tonifying speen and tonifying kidney.1. " grandson true man's food is avoided ": " ephrosis should be eaten." 2. the Meng numerous: " tonifying five zang organs, in tune, helps the twelve regular channels." 3. " Japan hanako materia medica ": " beans, warm stomach.Leaf, sharp the five internal organs, lower gas."
Psoralea corylifolia: kidney returned by Psoralea corylifolia; The heart; Spleen; Stomach; Lung channel.Show that Psoralea corylifolia stimulates keratinocyte release inflammatory mediator according to the study, act on melanophore growth factor, make remaining melanocyte proliferation in epidermis or hair follicle; Psoralea corylifolia taste is pungent; Bitter; Warm in naturely return through kidney; Pericardium; Spleen; Stomach; Lung channel function cures mainly: tonify the kidney and support yang; Promoting inspiration to relieve asthma; Warming spleen and stopping diarrha.The main insufficiency of the kidney yang; Below element deficiency and cold; Waist knee crymodynia; Impotence essence; Frequent micturition; The enuresis; The failure of the kidney in receiving air; Void is breathed heavily incessantly; Speen-kidney dificiency; Stool is rushed down for a long time." Bencao Jingshu ": Psoralea corylifolia, energy warming the kidney; Raw sun in the moon, the key medicine of sthenic fire benefit soil also.Its main general debility, the disease of lid edge internal lesion caused by overexertion, a lot of in speen-kidney dificiency, with its can warming the kidney, mend fire with the immature soil, then in kidney kidney-Yang be so incensed that mend and rise, then can digesting food, steam waste matter and change precise and tiny.Spleen-QI transporting the essence to the whole body is attributed to lung, supports the five internal organs with honor, therefore the labor of main the five internal organs.The seven human emotions hinder disease of viscera connecting with this channel.Wind empty cold person, because yang-energy is decayed, and the then air-cooled visitor that takes advantage of a weak point in opponent's defence so that marrow wound loses, the cold essence stream of kidney, and Shen controls bone store essential substances, marrow be essence this, the gas of kidney-Yang is solid, and namely, card is shown in, solid itself and yang-energy life, then front card removes in vain.Man is based on essence, and married woman is based on blood, and married woman vim and vigour person, also still man's sun kidney that declines is cold and be the degassed sunken disease of blood, and the cold essence stream of the kidney with man also.
Galingal: bitter, cold.Function cures mainly: heat-clearing, regulates the flow of vital energy, pain relieving.For acute gastroenteritis, indigestion, heatstroke is suffered from abdominal pain, stomachache.
Embodiment 1 Chinese medicine additive 1
By the root of straight ladybell 28g, stem of noble dendrobium 21g, cutter ash tree 23g, honeysuckle 26g, dried orange peel 29g, cloves 17g, the tuber of dwarf lilyturf 18g, sweet potato 21g, Chinese coffeetree fruit 23g, scarlet kadsura root 27g, the 16g that delivers vegetables, Chinese herbaceous peony 18g, honeycomb 23g, garlic 10g, the membrane of a chicken's gizzard 27g, Plant Soot 27g, rice sprout 25g, date 20g, white peas or beans 17g, Psoralea corylifolia 14g and galingal 8g drop into mixer, stir 50 minutes, abundant mixing, pulverizes; The water relative to described mixture quality 4 times is added in the mixture after pulverizing, decoct 3 hours, filter, add in filter residue and again decoct 2 hours relative to the water of 2 times, described mixture, filter, by twice filtrate mixing, reduced pressure concentration removing moisture, obtain dry lotion, dry with spray dryer further and pulverize, sieve acquisition 100 order Chinese medicine additive fine powder.
Embodiment 2 feed 1
The invention provides a kind of feed being used for the treatment of swine gastric ulcer, feed is made up of the raw material of following parts by weight: corn 70 weight portion, dregs of beans 50 weight portion, spinach powder 30 weight portion, pumpkin powder 30 weight portion, dried mushroom powder 40 weight portion, antioxidant 9 weight portion and Chinese medicine additive 12 weight portion.
Wherein, above-mentioned Chinese medicine additive is the Chinese medicine additive in embodiment 1; Antioxidant is vitamin E, vitamin C, zinc sulfate and magnesium sulfate.
The preparation method of feed comprises the following steps: be ground into 200 object powder after corn, dregs of beans, spinach powder, pumpkin powder and dried mushroom powder being mixed, ferment 7 days, and controlled by fermentation temperature at 120 DEG C; Powder is broken into after drying at 70 DEG C after fermenting, the Chinese medicine additive fine powder obtained with the first step and antioxidant mix, pour into and be placed in the granulating disc of heeling condition, opening granulating disc makes it rotate, the rotating speed of granulating disc is 50 revs/min, preparation time is 15 minutes, is prepared into the spherical particle feed that diameter is 1 millimeter; By the spherical particle feed obtained, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, import air temperature of heating is 150 degree, and outlet air temperature is 80 degree, obtains dry feed granules.
Embodiment 3 feed 2
The embodiment of the present invention 3 provides a kind of feed being used for the treatment of swine gastric ulcer, and feed is made up of the raw material of following parts by weight: corn 60 weight portion, dregs of beans 40 weight portion, spinach powder 35 weight portion, pumpkin powder 40 weight portion, dried mushroom powder 50 weight portion, antioxidant 7 weight portion and Chinese medicine additive 12 weight portion.
Wherein, Chinese medicine additive is made up of the bulk drug of following parts by weight: the root of straight ladybell 35 weight portion, the stem of noble dendrobium 15 weight portion, cutter ash tree 25 weight portion, honeysuckle 20 weight portion, dried orange peel 20 weight portion, cloves 15 weight portion, the tuber of dwarf lilyturf 17 weight portion, sweet potato 19 weight portion, Chinese coffeetree fruit 22 weight portion, scarlet kadsura root 28 weight portion, to deliver vegetables 19 weight portions, Chinese herbaceous peony 12 weight portion, honeycomb 25 weight portion, garlic 12 weight portion, the membrane of a chicken's gizzard 33 weight portion, Plant Soot 25 weight portion, rice sprout 24 weight portion, date 20 weight portion, white peas or beans 15 weight portion, Psoralea corylifolia 12 weight portion and galingal 8 weight portion.
The preparation method of Chinese medicine additive comprises the following steps: all bulk drugs are dropped in proportion mixer and stir 30 ~ 50 minutes, fully mix, pulverize; The water relative to described mixture quality 2 ~ 4 times is added in the mixture after pulverizing, decoct 2 ~ 4 hours, filter, add in filter residue and again decoct 1 ~ 2 hour relative to the water of 1 ~ 2 times, described mixture, filter, by twice filtrate mixing, reduced pressure concentration removing moisture, obtain dry lotion, dry with spray dryer further and pulverize, sieve acquisition 50 ~ 100 order Chinese medicine additive fine powder.
Antioxidant is vitamin E, vitamin C, zinc methionine, chromium picolinate, yeast selenium, zinc sulfate, magnesium sulfate.
The preparation method of feed comprises the following steps:
The first step, the Chinese medicine additive fine powder prepared according to above-mentioned steps;
Second step, is ground into 100 object powder after corn, dregs of beans, spinach powder, pumpkin powder and dried mushroom powder being mixed, ferments 7 days, and controlled by fermentation temperature at 120 DEG C; Powder is broken into after drying at 60 DEG C after fermenting, the Chinese medicine additive fine powder obtained with the first step and antioxidant mix, pour into and be placed in the granulating disc of heeling condition, opening granulating disc makes it rotate, the rotating speed of granulating disc is 50 revs/min, preparation time is 15 minutes, is prepared into the spherical particle feed that diameter is 1 millimeter;
3rd step, by the spherical particle feed that second step obtains, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, import air temperature of heating is 150 degree, and outlet air temperature is 80 degree, obtains dry feed granules.
Toxicity test
Select SD rat, give the Chinese medicine additive lysate of the embodiment of the present invention 1 of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the changes of weight of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range (NR), without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, and the dose safety of the clinical practice of the prompting embodiment of the present invention 1 Chinese medicine additive is higher.Adopt identical test method to carry out toxicity test to the Chinese medicine additive in the embodiment of the present invention 3 feed 2, the dose safety of the clinical practice of the Chinese medicine additive in the same proof embodiment of the present invention 3 feed 2 is higher.
Clinical testing
(1) animal used as test
Pig farm, Zibo City of Shandong Province found to fatten the phenomenon that pig die by visitation of God appears in swinery in August, 2012, clinical examination is carried out to swinery, in discovery swinery, some pig occurs that poor appetite, spirit are poor and many with vomiting phenomenon, sick dead pig occurs discharging color of soy sauce loose stool before death, smell is smelt as of rotten fish, with vomiting and vomitus mostly is the chyme being mixed with blood, find after dissecting that blood is thin, there is the circle that differs in size or oval ulcer surface in stomach orifice of the stomach district, ulcer surface is brown, chap, stomach base area large-area hemorrhage.On inspection, there are 200 pigs nearly to suffer from gastric ulcer, select 162 body weight in the ill pig experiment pig the most of about 75kg.
(2) test method
By 162 ill pigs with entering to be divided into three experimental group, often organize 54, often organizing average weight is 75kg.Three components does not use the feed 1(embodiment group 2 of the Chinese medicine additive of the embodiment of the present invention 1 (embodiment group 1), embodiment 2), the feed 2(embodiment group 3 of embodiment 3) and conventional medicament (control group) treat.Embodiment 1 adds Chinese medicine additive according to the percentage by weight of feed 3-8% in traditional pig feed; Embodiment group 2 and 3 traditionally feed feeding method uses feed 1 and feed 2 to feed ill pig; Conventional medicament is mixed in conventional feed after selecting bismuth subnitrate sheet to pulverize, and mixed volume is 1-3g/ head.Test period is 5-7 days.
(3) criterion of therapeutical effect
Effective: the treatment time limit is for mostly to be most 5 days, and appetite, spirit and defecation etc. all recover normally, symptoms of emesis disappears; Effective: the treatment time limit is 6 days or 7 days, and appetite takes a turn for the better to some extent, mental restoration is normal, and ight soil is normal, without vomiting phenomenon; Invalid: poor appetite, spirit is not improved, and still has vomiting phenomenon.
(4) treatment results
The results are shown in Table 1, from result for the treatment of, adopt Chinese medicine additive of the present invention to be 97.6% to the treated effect of swine gastric ulcer, higher than control group.
Data as can be seen from table 1: compared with control group, the Chinese medicine additive of the embodiment of the present invention 1 is used to have good result for the treatment of, use the feed result for the treatment of of the embodiment of the present invention 2 and 3 best, feed of the present invention treatment swine gastric ulcer, has treatment time short, the advantage such as result for the treatment of is good.
Concrete case
Case 1
In July, 2012, there are 52 years old sows in Wu family due to the busy not free purchase perfect compound feed of housework, only to feed corn flour, feed about two weeks, find that the symptom of anaemia, vomiting, poor appetite and spirit depression all appears in 5 sows, and ight soil becomes pitch sample, wherein there is a sow to occur haematemesis phenomenon once in a while, be diagnosed as gastric ulcer.In feed, add the Chinese medicine additive of the embodiment of the present invention 1 of feed gross weight 8%, adhere to use 6 days, 5 sows all recover normal, and normally, Anemia disappears for appetite and mental restoration.
Case 2
In July, 2011, Lee's raiser 121 growing and fattening pigs, there is poor appetite, the symptom that spirit is low in the pig of nearly 70, even have indivedual pig spitting blood, skin whitening, body temperature is normal, two pig death.Find through censorship, there is the circle that differs in size or oval ulcer surface in sick dead pig stomach orifice of the stomach district, ulcer surface is brown, chaps, and stomach base area large-area hemorrhage, is diagnosed as gastric ulcer.Use the feed of the embodiment of the present invention 2 to feed 67 ill pigs, use 5 days continuously, 61 ill pigs all recover normal, appetite and mental restoration normal, Anemia disappears, and several ill pigs continue use two days in addition, also all recovers normal, transference cure.
Embodiment 3
In September, 2012, grandson's raiser 5 growing and fattening pigs, all occurred the symptom of anaemia, vomiting, poor appetite and spirit depression, and ight soil become pitch sample, wherein has a sow to occur haematemesis phenomenon once in a while, is diagnosed as gastric ulcer.Use the feed of the embodiment of the present invention 3 to feed ill pig, use 6 days continuously, ill pig all recovers normal, appetite and mental restoration normal, Anemia disappears.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. be used for the treatment of the feed of swine gastric ulcer, it is characterized in that, described feed is made up of the raw material of following parts by weight: corn 60-80 weight portion, dregs of beans 40-60 weight portion, spinach powder 20-40 weight portion, pumpkin powder 20-40 weight portion, dried mushroom powder 20-50 weight portion, antioxidant 5-15 weight portion and Chinese medicine additive 5-20 weight portion;
Described Chinese medicine additive is made up of the bulk drug of following parts by weight: the root of straight ladybell 20-35 weight portion, stem of noble dendrobium 15-25 weight portion, cutter ash tree 15-30 weight portion, honeysuckle 20-35 weight portion, dried orange peel 20-35 weight portion, cloves 10-25 weight portion, the tuber of dwarf lilyturf 10-22 weight portion, sweet potato 15-25 weight portion, Chinese coffeetree fruit 20-25 weight portion, scarlet kadsura root 25-30 weight portion, to deliver vegetables 10-25 weight portion, Chinese herbaceous peony 10-25 weight portion, honeycomb 15-25 weight portion, garlic 8-12 weight portion, the membrane of a chicken's gizzard 22-33 weight portion, Plant Soot 22-30 weight portion, rice sprout 20-30 weight portion, date 15-25 weight portion, white peas or beans 10-20 weight portion, Psoralea corylifolia 10-15 weight portion and galingal 5-15 weight portion.
2. the feed being used for the treatment of swine gastric ulcer according to claim 1, it is characterized in that, described feed is made up of the raw material of following parts by weight: corn 70 weight portion, dregs of beans 50 weight portion, spinach powder 30 weight portion, pumpkin powder 30 weight portion, dried mushroom powder 40 weight portion, antioxidant 9 weight portion and Chinese medicine additive 12 weight portion.
3
.the feed being used for the treatment of swine gastric ulcer according to claim 1, it is characterized in that, described Chinese medicine additive is made up of the bulk drug of following parts by weight: the root of straight ladybell 28 weight portion, the stem of noble dendrobium 21 weight portion, cutter ash tree 23 weight portion, honeysuckle 26 weight portion, dried orange peel 29 weight portion, cloves 17 weight portion, the tuber of dwarf lilyturf 18 weight portion, sweet potato 21 weight portion, Chinese coffeetree fruit 23 weight portion, scarlet kadsura root 27 weight portion, to deliver vegetables 16 weight portions, Chinese herbaceous peony 18 weight portion, honeycomb 23 weight portion, garlic 10 weight portion, the membrane of a chicken's gizzard 27 weight portion, Plant Soot 27 weight portion, rice sprout 25 weight portion, date 20 weight portion, white peas or beans 17 weight portion, Psoralea corylifolia 14 weight portion and galingal 8 weight portion.
4
.the feed being used for the treatment of swine gastric ulcer according to any one of claim 1-3, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps: all bulk drugs are dropped in proportion mixer and stir 30 ~ 50 minutes, fully mix, pulverize; The water relative to described mixture quality 2 ~ 4 times is added in the mixture after pulverizing, decoct 2 ~ 4 hours, filter, add in filter residue and again decoct 1 ~ 2 hour relative to the water of 1 ~ 2 times, described mixture, filter, by twice filtrate mixing, reduced pressure concentration removing moisture, obtain dry lotion, dry with spray dryer further and pulverize, sieve acquisition 50 ~ 100 order Chinese medicine additive fine powder.
5
.the feed being used for the treatment of swine gastric ulcer according to claim 1, is characterized in that, described antioxidant is one or more in vitamin E, vitamin C, zinc methionine, chromium picolinate, yeast selenium, zinc sulfate, magnesium sulfate.
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| CN103947860B (en) * | 2014-03-18 | 2016-01-27 | 李长林 | Fragrant fermented-pig feed of a kind of paddy and preparation method thereof |
| CN104351563A (en) * | 2014-11-27 | 2015-02-18 | 山东新希望六和集团有限公司 | Functional feed used for preventing pig malignant edema and preparation method of functional feed |
| CN105285389A (en) * | 2015-10-21 | 2016-02-03 | 黑龙江省农业科学院畜牧研究所 | Feed additive capable of preventing and treating gastritis of Min pigs as well as preparation method and application of feed additive |
| CN107173530A (en) * | 2017-06-23 | 2017-09-19 | 舒城县明公农业开发有限责任公司 | A kind of feed for improving pork selenium content |
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Effective date of registration: 20201221 Address after: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 266061 Qingdao Industrial Park, Ji Hong Tan Street, Chengyang District, Qingdao, Shandong. Patentee before: SHANDONG NEW HOPE LIUHE GROUP Co.,Ltd. |
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Address after: 253211 Guozhai Forest Farm, Suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province (5F, Qingwo Pioneer Park Office Building, Xiajin Economic Development Zone) Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee before: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. |
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