CN105285418A - Formula feed for swine and preparation method thereof - Google Patents

Abstract

The invention discloses a formula feed for swine and a preparation method thereof. The feed comprises the following raw materials: wheat, wheat bran, corn, white radishes, water chestnuts, cabbage roots, pears, garlic, oat, peanuts, walnut kernels, red cabbages, soybean meal, spinaches, salt, vitamin premix and trace element premix. The preparation method comprises the steps of grinding, mixing and granulating. The formula feed has the beneficial effects that the feed contains a traditional Chinese medicine additive with the functions of clearing away heat and gathering qi and clearing away the lung-heat and relieving asthma, so that the feed can achieve the function of strengthening healthy qi to eliminate pathogens and has the advantages of shorter course of treatment, better curative effects, no medicine residues, low cost and price, and the like; and the traditional Chinese medicine additive and other feed raw materials are matched with each other and interact, so that not only can mycoplasma pneumonia of swine be treated but also the nutritional requirements of swine can be met.

Description

A kind of swine feed and preparation method thereof

Technical field

The present invention relates to bird feed, particularly a kind of swine feed and preparation method thereof.

Background technology

Swine enzootic pneumonia or mycoplasma pneumonia of swine, also known as mycoplasma hyopneumoniae, are a kind of chronic respiratory infectious diseases of pig.The main clinic symptoms of this disease is cough and asthma, and pathological change position is mainly positioned at thoracic cavity.Lungs are major organs of pathology.Acute case is based on pulmonary edema and pulmonary emphysema; Subacute and chronic cases is shown in lung's " shrimp " sample consolidation.The speed of growth of morbidity pig is slow, and efficiency of feed utilization is low, and the feeding for fattening phase extends.

Have pig-raising countries all to have this disease popular, this disease is caused by mycoplasma hyopneumoniae.The infection of sucking pig is mostly suffered from by contact caused by the sow of this disease.Infected sucking pig relays other pigs again when weaning.Dense husbandry can promote that it is propagated.The incubation period of this disease is longer, therefore has more swinery infected under not realized, causes this disease often to be deposited in what swinery.The infection rate of this disease is high, and the death rate is low, but can cause growth disorder and reduce meat change rate.

Mycoplasma hyopneumoniae is mainly present in the respiratory tract of infected pigs, lung tissue, hilar lymph node and vertical phrenic lymph nodes, and sick pig and the pig that carries disease germs are its major source of infection.Its route of transmission mainly contains: respiratory infectious, direct contact infection and droplet transmission, pathogeny Jun Zhi infected pigs; Initial infection mycoplasma hyopneumoniae is present in trachea and bronchus surface, and damages mucous membrane-cilium barrier, makes bronchus and blood vessel peripheral lymphoid like cell hyperplasia (immune response obviously participates in pathological development and causes lungs generation consolidation); Infected pigs mainly betides the later stage (after infecting 15 ~ 20 weeks) of disease to the immune response of mycoplasma hyopneumoniae, and this infection has certain immunosuppressive action as can be seen here.

This sick Winter-Spring is common for cold season, and the four seasons all can occur.Pig house improper ventilation, swinery are crowded, abrupt change of climate, and dark and damp cold, feeding and management and sanitary condition are bad promotes that this disease occurs, and increase the weight of the state of an illness, if any scabies secondary infection, then the state of an illness is heavier.Common Secondary cases pathogen has Pasteurella, pneumococcus etc.There is the normal break out and spread of this disease in pig farm, get acute process, severe symptoms, case fatality rate is high more first.Mostly be chronic or recessive process on pig farm, old epidemic-stricken area, symptom is not obvious, and case fatality rate is low.

Western medical treatment swine enzootic pneumonia generally uses antibiotic, as Enrofloxacin ,tiamulin ,kanamycins etc.But antibiotic Long-Time Service, not only to the toxic effect of pig itself, is unfavorable for the growth of pig, also endanger the health of people, and medicine cost is high, is unfavorable for increasing economic efficiency simultaneously.

But Chinese medicine swine enzootic pneumonia not only has the antiviral of western modern medicine waits effect, also can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill pig, selected natural Chinese traditional medicines material, make drug effect directly arrive focus, the course for the treatment of is shorter, curative effect is better, the advantages such as prolonged application has no drug resistance, drug residue free, and cost price is cheap.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of feed of Chinese medicine additive containing being used for the treatment of swine enzootic pneumonia, the Feed Energy containing this Chinese medicine additive is adopted to overcome the various defects of Chinese medicine of the prior art and Western medicine, there is the effect of heat-clearing astringe qi, clearing lung, relieving asthma, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill pig, the course for the treatment of is shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, and cost price is cheap.

In order to realize foregoing invention object, the invention provides a kind of swine feed, described feed comprises following raw material: wheat, wheat bran, corn, ternip, water chestnut, Pemisetum flaccidum Griseb, pears, garlic, oat, peanut, walnut kernel, violet cabbage, dregs of beans, spinach, salt, vitamin premix and microelement pre-mix material.

In described feed, the parts by weight of each raw material are: wheat 50-70 weight portion, wheat bran 100-140 weight portion, corn 30-40 weight portion, ternip 15-20 weight portion, water chestnut 15-25 weight portion, Pemisetum flaccidum Griseb 15-30 weight portion, pears 10-30 weight portion, garlic 6-9 weight portion, oat 20-30 weight portion, peanut 10-15 weight portion, walnut kernel 10-20 weight portion, violet cabbage 10-20 weight portion, dregs of beans 10-30 weight portion, spinach 10-15 weight portion, salt 0.2-0.5 weight portion, vitamin premix 0.1-0.5 weight portion and microelement pre-mix material 0.1-0.5 weight portion.

Described feed also comprises Chinese medicine additive, in described feed, the parts by weight of each raw material are: wheat 50-70 weight portion, wheat bran 100-140 weight portion, corn 30-40 weight portion, ternip 15-20 weight portion, water chestnut 15-25 weight portion, Pemisetum flaccidum Griseb 15-30 weight portion, pears 10-30 weight portion, garlic 6-9 weight portion, oat 20-30 weight portion, peanut 10-15 weight portion, walnut kernel 10-20 weight portion, violet cabbage 10-20 weight portion, dregs of beans 10-30 weight portion, spinach 10-15 weight portion, salt 0.2-0.5 weight portion, vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 2-4 weight portion.

In described feed, the parts by weight of each raw material are: wheat 55 weight portion, wheat bran 110 weight portion, corn 35 weight portion, ternip 18 weight portion, water chestnut 21 weight portion, Pemisetum flaccidum Griseb 22 weight portion, pears 25 weight portion, garlic 7 weight portion, oat 30 weight portion, peanut 12 weight portion, walnut kernel 11 weight portion, violet cabbage 17 weight portion, dregs of beans 25 weight portion, spinach 14 weight portion, salt 0.3 weight portion, vitamin premix 0.5 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 3 weight portion.

Described Chinese medicine additive comprises following raw medicinal material: stephanotis, desmodium, marginate American agave leaf, kalimeris, viola japonica, oriental wormwood, schizonepeta, tribulus terrestris, spina date seed, Radix Angelicae Sinensis, the Radix Astragali, insect wax, lingnan artocarpus fruit, bletilla, myrobalan, yellow hair purple bergenia herb, eupatorium lindleynun var. trifoliolatum, Syringa amurensis, Japanese Metaplexis Pericarp, thorny elaeagnus leaf, loguat leaf, Psoralea corylifolia, the stem of noble dendrobium, raspberry and Radix Glycyrrhizae.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: stephanotis 7-14 weight portion, desmodium 10-15 weight portion, marginate American agave leaf 10-17 weight portion, kalimeris 10-18 weight portion, viola japonica 9-18 weight portion, oriental wormwood 10-18 weight portion, schizonepeta 15-28 weight portion, tribulus terrestris 6-11 weight portion, spina date seed 17-27 weight portion, Radix Angelicae Sinensis 17-27 weight portion, Radix Astragali 22-31 weight portion, insect wax 10-16 weight portion, lingnan artocarpus fruit 10-16 weight portion, bletilla 10-15 weight portion, myrobalan 11-17 weight portion, yellow hair purple bergenia herb 10-18 weight portion, eupatorium lindleynun var. trifoliolatum 8-15 weight portion, Syringa amurensis 7-14 weight portion, Japanese Metaplexis Pericarp 12-19 weight portion, thorny elaeagnus leaf 8-15 weight portion, loguat leaf 12-20 weight portion, Psoralea corylifolia 15-25 weight portion, stem of noble dendrobium 12-19 weight portion, raspberry 18-26 weight portion and Radix Glycyrrhizae 10-18 weight portion.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: stephanotis 13 weight portion, desmodium 11 weight portion, marginate American agave leaf 12 weight portion, kalimeris 15 weight portion, viola japonica 13 weight portion, oriental wormwood 14 weight portion, schizonepeta 22 weight portion, tribulus terrestris 9 weight portion, spina date seed 25 weight portion, Radix Angelicae Sinensis 26 weight portion, the Radix Astragali 30 weight portion, insect wax 11 weight portion, lingnan artocarpus fruit 12 weight portion, bletilla 10 weight portion, myrobalan 14 weight portion, yellow hair purple bergenia herb 16 weight portion, eupatorium lindleynun var. trifoliolatum 12 weight portion, Syringa amurensis 11 weight portion, Japanese Metaplexis Pericarp 16 weight portion, thorny elaeagnus leaf 12 weight portion, loguat leaf 18 weight portion, Psoralea corylifolia 21 weight portion, the stem of noble dendrobium 15 weight portion, raspberry 21 weight portion and Radix Glycyrrhizae 14 weight portion.

The preparation method of described Chinese medicine additive comprises the following steps:

The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains Chinese medicine additive powder.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method of swine feed, and described preparation method comprises the following steps:

(1) destruction step: take wheat, wheat bran, corn, ternip, water chestnut, Pemisetum flaccidum Griseb, pears, garlic, oat, peanut, walnut kernel, violet cabbage, dregs of beans and spinach by ratio of weight and the number of copies, drop into pulverizer and carry out Crushing of Ultrafine, after pulverizing, cross 2.0mm sieve;

(2) batching step: take the described raw material of residue according to ratio of weight and number, pulverize the fine powder obtained mix with step (1), drop into mixer, mix, incorporation time is 30-60s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.

The invention has the beneficial effects as follows: feed of the present invention contains the Chinese medicine additive of effect with heat-clearing astringe qi, clearing lung, relieving asthma, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill pig, the course for the treatment of is shorter, and curative effect is better, has no drug resistance, drug residue free, cost price is cheap, promotes pig comparatively fast and grows healthily, increasing market efficiency.Chinese medicine additive and other feedstuffs cooperatively interact, and interact, can not only treat swine enzootic pneumonia, can also meet the nutritional need of pig, be specially adapted to the nutritional need of the pig suffering from swine enzootic pneumonia.

Detailed description of the invention

Chinese medicine additive refers to take as the leading factor with the traditional theory of China to the physical property of the Nature Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (sour, sweet, bitter, peppery, salty) and material relation and with the subjects theory such as raising and feed industry and technology for support, the single and compound Chinese herb feed additive developed or intermixture.From modern pharmacology Epidemiological Analysis, feed addictive based on Chinese herbal medicine effective ingredients, there is the immunologic function and non-specific antimicrobial effect that regulate body, Chinese herbal medicine contains alkaloid, polysaccharide, two class volatile oil, the bioactivator such as organic acid flavones and bioflavonoid of anti-antibacterial composition, to adjustment human body immune function, good effect of improving health conditions.It is reported, ward off more and there is the reaction of promotion thymus gland, stimulation reticuloendothelial cell raising specific antigen respond; Alkaloid can strengthen body fluid and cellular immune function, and the phagocytic function of stimulating expression of macrophage, two classes can strengthen the phagocytic function of reticuloendothelial system, and can generate by enhancing antibody, promote antigen-antibody reaction and lymphocyte transformation organic acid, intestines can be regulated interior and prevent the breeding of harmful bacteria and improve the activity of enzyme, animal body intracellular metabolic can normally be carried out.The nutriment of folding Chinese herbal feed additive not only containing some is divided from the theory of modern nutriology, but also contain unknown growth regulator and the pigment of some, there is the biochemical reaction activating body directly or indirectly, strengthen biosynthesis effect, thus promote the production performance of animal.

Chinese medicine additive of the present invention is mainly theoretical according to traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, theory of traditional Chinese medical science think righting and eliminating evil be two aspects connected each other, righting is in order to eliminating evil, by strengthening the method for healthy tendency, get rid of evils and go out, thus get well, be i.e. so-called " just containing evil in dispelling ".Eliminating evil is in order to righting, eliminates the infringement of paathogenic factor and reaches protection healthy tendency, restorative object, i.e. so-called " heresy is gone just from peace ".Righting and eliminating evil be complementary two aspects.When therefore using the rules for the treatment of of strengthening vital QI to eliminate pathogenic factors, conscientiously to carefully analyze the contrast situation of good and evil strength, know the secondary from the primary, determine righting or eliminating evil, or determine the priority of strengthening vital QI to eliminate pathogenic factors.Generally, righting is used for asthenic symptoms; Eliminating evil for real example; If belong to mixture of asthenia and sthenia card, then answer strengthening vital QI to eliminate pathogenic factors and use, but this taking into account not being righting and eliminating evil half and half, is the primary and secondary emergency will distinguishing actual situation, to determine the primary and secondary, successively of strengthening vital QI to eliminate pathogenic factors.In a word, should with " righting is unlikely stays heresy, eliminating evil just do not causing injury " for degree.

Chinese medicine additive of the present invention follows the general principle of " strengthening vital QI to eliminate pathogenic factors ", follow the principle of heat-clearing astringe qi, clearing lung, relieving asthma, provide a kind of swine feed, it comprises Chinese medicine additive, and Chinese medicine additive comprises following raw medicinal material: stephanotis, desmodium, marginate American agave leaf, kalimeris, viola japonica, oriental wormwood, schizonepeta, tribulus terrestris, spina date seed, Radix Angelicae Sinensis, the Radix Astragali, insect wax, lingnan artocarpus fruit, bletilla, myrobalan, yellow hair purple bergenia herb, eupatorium lindleynun var. trifoliolatum, Syringa amurensis, Japanese Metaplexis Pericarp, thorny elaeagnus leaf, loguat leaf, Psoralea corylifolia, the stem of noble dendrobium, raspberry and Radix Glycyrrhizae.Wherein, stephanotis, desmodium, marginate American agave leaf, kalimeris, viola japonica, the removing toxic substances of oriental wormwood clearing heat and promoting diuresis; Schizonepeta, tribulus terrestris are induced sweat loose wind; Spina date seed, Radix Angelicae Sinensis, the Radix Astragali, insect wax, lingnan artocarpus fruit, bletilla, myrobalan's moistening lung astringe qi; Yellow hair purple bergenia herb, eupatorium lindleynun var. trifoliolatum, Syringa amurensis, Japanese Metaplexis Pericarp, thorny elaeagnus leaf, loguat leaf clearing lung, relieving asthma; Psoralea corylifolia, the stem of noble dendrobium, raspberry are tonified the kidney to improve inspiration; Radix Glycyrrhizae coordinating the drug actions of a prescription, strengthening the spleen and replenishing qi.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Stephanotis: be Menispermaceae stephania plant headdress flower Japanese Stephania Root, be used as medicine with block root.Hardship, cold.Clearing heat and detoxicating, cooling blood and hemostasis, eliminating stasis to subdue swelling.For oxyhepatitis, bacillary dysentery, acute appendicitis, stomachache, internal haemorrhage, traumatic injury, venomous snake bite; Mumps is controlled in external application, lymphnoditis, neurodermatitis.

Desmodium: another name christina loosestrife herb, to seat grass, LUBIANHUANG, everywhere Huang, copper coin careless, Yi Chuanqian, very little bone seven.This product is the dry herb of Ofthe Primulaceae Lysimachia christinae.Sweet, salty, be slightly cold.Return liver, courage, kidney, urinary bladder channel.Eliminating dampness and heat, treating stranguria, detumescence.Drench for heat, Sha Lin, urinate and puckeryly to have a pain, jaundice urine is red, and carbuncle swells furunculosis, venomous snake bite; Liver and bile stone, lithangiuria.

Marginate American agave leaf: Agavaceae agave marginate American agave leaf is used as medicine with fresh leaf.Pungent, flat.Moisten the lung and relieve the cough, relieving asthma, promoting eruption, removing blood stasis for promoting tissue regeneration.For xeropulmonary cough, the deficiency of Yin is breathed with cough, measles without adequate eruption, sore.

Kalimeris: pungent, bitter, cold.Clearing heat and detoxicating, loose stasis of blood hemostasis, disappears long-pending.For cat fever, cough, acpuei pharyngitis, tonsillitis, mumps, catarrhal jaundice, taste-blindness rate, infantile malnutrition, enteritis, dysentery, spits blood, uterine bleeding, irregular menstruation; Sore furuncle pain is controlled in external application, mastitis, traumatism and bleeding.

Viola japonica: another name whiteflower violet herb with root, plowpoing, plough mouth grass, arrow are careless, grass of complying with one's wishes, jade are complied with one's wishes, tack is careless.Viola dish section Viola Lepidium plant viola japonica or viola inconspicua Blume, with all herbal medicine.Bitter, micro-pungent, cold.Clearing heat and detoxicating, cool blood detumescence.For acute conjunctivitis, sphagitis, acute icteric hepatitis, mastitis, carbuncle furuncle poison, pyogenic osteomyelitis, venomous snake bite.

Oriental wormwood: another name capillary wormwood, Artemisia capillaris, Artemisia stelleriana, suede wormwood artemisia, monkey hair.This product is the dry aerial parts of feverfew shore wormwood artemisia or Artemisia capillaris.Bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder channel.Clearing away damp-heat, removing jaundice subcutaneous ulcer.For jaundice oliguria, wet sore itch; Infectious jaundice type hepatitis.

Schizonepeta: pungent, tepor.Return lung, Liver Channel.Induce sweat loose wind, promoting eruption.For flu, headache, measles, rubella, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.

Tribulus terrestris: another name thatch, puncture vine, Fructus Tribuli, bypass, people's tribulus terrestris in the wrong, society puncture vine soil puncture vine, tribulus terrestris.: be the fruit of zygophyllaceae plant puncture vine and great Hua disease lamb's-quarters.Bitter; Pungent; Property is put down.Return liver; Lung; Kidney; The heart channel of Hang-Shaoyin.Flat liver; Xie Yu; Dispelling pathogenic wind for improving eyesight.Main headache; Dizzy; Distending pain in the chest and hypochondrium; Swollen breasts; Breast closes obstructed; Through closing; Cataract; Rubella itch; Leucoderma; Sore subcutaneous ulcer; Scrofula.

Spina date seed: sweet, sour is flat.Return liver, courage, the heart channel of Hang-Shaoyin.Tonifying liver, Ning Xin, arrest sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hidrosis of body, Tianjin wound is thirsty.

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, the spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, relax bowel.Sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine activating blood to promote menstruation.For through closing dysmenorrhoea, arthralgia due to wind-dampness, injury from falling down.

The Radix Astragali: sweet, temperature.Return lung, the spleen channel.Invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, and ulcer difficulty is burst, and burst for a long time and do not hold back, flaccidity of limbs due to deficiency of blood is yellow, and interior heat is quenched one's thirst; Chronic rephrilis protinuria, diabetes.

Insect wax: another name Chinese wax, insect wax, haze tallow, vegetable wax, slack wax.Wax secreted by the male worm of a red-spotted lizard section (Coccidae) animal white wax insect is refining to be formed.Slightly sweet flavor; Warm in nature.Return Liver Channel.Hemostasis; Myogenic; Analgesic therapy.Main metal-inflicted wound is hemorrhage; Hematuria; Have blood in stool; Sore is burst for a long time and is not held back.Lingnan artocarpus fruit:

Bletilla: call white root, Pseudobulbus Bletillae (Rhizoma Bletillae), Cold boiled chicken, Cold boiled chicken baby, Lian Jicao, YANGJIAOQI.This product is the dry tuber of orchid bletilla.Bitter, sweet, puckery, be slightly cold.Return lung, liver, stomach warp.Astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Tonifying lung, hemostasis, detumescence, myogenic, sore.Control lung and hinder hemoptysis, bleeding from five sense organs or subcutaneous tissue, metal-inflicted wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.

Myrobalan: another name chebule.This product is the dry mature fruit of combretaceae plant myrobalan or fine hair myrobalan.Bitter, sour, puckery, flat.Return lung, large intestine channel.Puckery intestines are astringed the lung, and fall fiery relieve sore throat.For rushing down protracted dysentery for a long time, prolapse of the anus of having blood in stool, the deficiency syndrome of the lung is breathed with cough, and coughs for a long time more than, pharyngalgia hoarsen.

Yellow hair purple bergenia herb: light, flat.Removing heat from the lung to relieve cough, relievings asthma, hemostasis.For epersalgia cough, asthma, spits blood.

Eupatorium lindleynun var. trifoliolatum: composite family feverwort three blade tip eupatorium, with all herbal medicine.Hardship, flat.Clearing lung-heat, cough-relieving, relievings asthma, hypotensive.For bronchitis, high blood pressure.

Syringa amurensis: another name lotus cloves, white lilac.Oleaceae genus syringa syringa reticulata var mandshurica, is used as medicine with trunk and branch.Hardship, is slightly cold.Lung heat clearing away, sputum eliminating, relieving cough and asthma.For cough, bronchitis, bronchial astehma.

Japanese Metaplexis Pericarp: call sky by shell (" medicine materical crude slice is newly joined "), trailing plants Japonica pod (" pharmacognosy ").For the shell of Asclepiadaceae plant trailing plants Japonica.Taste is sweet, pungent, property is put down.Return lung; Kidney channel.Clearing lung and eliminating phlegm; Loose stasis of blood hemostasis.Main coughing with a lot of sputum; Asthma; Pertussis; Frightened epilepsy; Measles without adequate eruption; Traumatic injury; Traumatism and bleeding.Clearing lung and eliminating phlegm.Control coughing with a lot of sputum, productive asthma with cold, pertussis, frightened sick, measles without adequate eruption.

Thorny elaeagnus leaf: taste acid; Slightly warm in nature.Return lung channel.Relieving cough and asthma; Hemostasis; Removing toxic substances.Main cough due to deficiency of the lung; Asthma; Hemoptysis; Spit blood; Traumatism and bleeding; Ulcer; Hemorrhoid gall.

Loguat leaf: bitter, is slightly cold.Attach to the lung and stomach meridians.Removing heat from the lung to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough with lung heat, the circulation of vital energy in the wrong direction breathes heavily urgency, and stomach energy is vomitted inverse, and dysphoria with smothery sensation is thirsty.

Psoralea corylifolia: pungent, bitter, temperature.Return kidney, the spleen channel.Warming kidney and enhancing yang, receives gas, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, waist knee crymodynia, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External application curing vitiligo, alopecia areata.

The stem of noble dendrobium: sweet, is slightly cold.Return stomach, kidney channel.Reinforcing stomach reg fluid is nourishing Yin and clearing heat.Hinder body fluid deficiency for the moon, dry polydipsia, food is few retches, and abnormal heat after being ill, order is secretly failed to understand.

Raspberry: sweet, sour, temperature.Return kidney, urinary bladder channel.Kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine.For enuresis with renal asthenia, frequent urination, impotence and premature ejaculation, emission and spermatorrhea.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung channel." herbal classic " is said: " main the five internal organs six mansion fever and chills perverse trend, hard muscles and bones, longue meat, times power, metal-inflicted wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " crymodynia in main abdomen, controls frightened epilepsy, except distention and fullness in the abdomen; Help the five internal organs; Make all medicines poison; Support kidney qi internal injury, make impotence; Housewife's human blood drop pain in the back; Empty and how heat; Add and with it ".Can beneficial gas bowl spares, relieving spasm to stop pain, moistens the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription.Main burnout food is few, flesh thin Huang, palpitation, stomachache loose stool, and the anxious pain of four limbs contraction, hysteria, cough and asthma, abscess of throat, carbuncle sore swells and ache, infant fetal toxin, and medicine, food poisoning.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 Chinese medicine additive

Get stephanotis 13 weight portion, desmodium 11 weight portion, marginate American agave leaf 12 weight portion, kalimeris 15 weight portion, viola japonica 13 weight portion, oriental wormwood 14 weight portion, schizonepeta 22 weight portion, tribulus terrestris 9 weight portion, spina date seed 25 weight portion, Radix Angelicae Sinensis 26 weight portion, the Radix Astragali 30 weight portion, insect wax 11 weight portion, lingnan artocarpus fruit 12 weight portion, bletilla 10 weight portion, myrobalan 14 weight portion, yellow hair purple bergenia herb 16 weight portion, eupatorium lindleynun var. trifoliolatum 12 weight portion, Syringa amurensis 11 weight portion, Japanese Metaplexis Pericarp 16 weight portion, thorny elaeagnus leaf 12 weight portion, loguat leaf 18 weight portion, Psoralea corylifolia 21 weight portion, the stem of noble dendrobium 15 weight portion, raspberry 21 weight portion and Radix Glycyrrhizae 14 weight portion.

Preparation method comprises the following steps:

The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, adds hot reflux 2 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 times to be again the ethanol of 95%, to add hot reflux 3 hours that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 hour, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, obtains powder.

Embodiment 2 feed

Embodiments provide a kind of feed being used for the treatment of swine enzootic pneumonia, in feed, the parts by weight of each raw material are: wheat 55 weight portion, wheat bran 110 weight portion, corn 35 weight portion, ternip 18 weight portion, water chestnut 21 weight portion, Pemisetum flaccidum Griseb 22 weight portion, pears 25 weight portion, garlic 7 weight portion, oat 30 weight portion, peanut 12 weight portion, walnut kernel 11 weight portion, violet cabbage 17 weight portion, dregs of beans 25 weight portion, spinach 14 weight portion, salt 0.3 weight portion, vitamin premix 0.5 weight portion and microelement pre-mix material 0.3 weight portion.

Its preparation method comprises the following steps:

(1) destruction step: take wheat, wheat bran, corn, ternip, water chestnut, Pemisetum flaccidum Griseb, pears, garlic, oat, peanut, walnut kernel, violet cabbage, dregs of beans and spinach by ratio of weight and the number of copies, drop into pulverizer and carry out Crushing of Ultrafine, after pulverizing, cross 2.0mm sieve;

(2) batching step: take the described raw material of residue according to ratio of weight and number, pulverize the fine powder obtained mix with step (1), drop into mixer, mix, incorporation time is 50s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.

Embodiment 3 feed

Embodiments provide a kind of feed being used for the treatment of swine enzootic pneumonia, in feed, the parts by weight of each raw material are: wheat 55 weight portion, wheat bran 110 weight portion, corn 35 weight portion, ternip 18 weight portion, water chestnut 21 weight portion, Pemisetum flaccidum Griseb 22 weight portion, pears 25 weight portion, garlic 7 weight portion, oat 30 weight portion, peanut 12 weight portion, walnut kernel 11 weight portion, violet cabbage 17 weight portion, dregs of beans 25 weight portion, spinach 14 weight portion, salt 0.3 weight portion, vitamin premix 0.5 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 3 weight portion, wherein Chinese medicine additive is the Chinese medicine additive powder of embodiment 1.

Its preparation method comprises the following steps:

(1) destruction step: take wheat, wheat bran, corn, ternip, water chestnut, Pemisetum flaccidum Griseb, pears, garlic, oat, peanut, walnut kernel, violet cabbage, dregs of beans and spinach by ratio of weight and the number of copies, drop into pulverizer and carry out Crushing of Ultrafine, after pulverizing, cross 2.0mm sieve;

(2) batching step: take the described raw material of residue according to ratio of weight and number, pulverize the fine powder obtained mix with step (1), drop into mixer, mix, incorporation time is 60s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.

The toxicity test of Chinese medicine additive:

1, trial drug

Choose stephanotis 13g, desmodium 11g, marginate American agave leaf 12g, kalimeris 15g, viola japonica 13g, oriental wormwood 14g, schizonepeta 22g, tribulus terrestris 9g, spina date seed 25g, Radix Angelicae Sinensis 26g, Radix Astragali 30g, insect wax 11g, lingnan artocarpus fruit 12g, bletilla 10g, myrobalan 14g, yellow hair purple bergenia herb 16g, eupatorium lindleynun var. trifoliolatum 12g, Syringa amurensis 11g, Japanese Metaplexis Pericarp 16g, thorny elaeagnus leaf 12g, loguat leaf 18g, Psoralea corylifolia 21g, stem of noble dendrobium 15g, raspberry 21g and Radix Glycyrrhizae 14g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filter residue; Again add in 1400g cold water by filtering the filter residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtered fluid, obtaining the second filtrate; Merge twice filtrate, reduced pressure concentration remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the changes of weight of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range (NR), without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Contrast test

In February, 2012, a collection of porkling is bought on pig farm, Shandong, sudden onset after buying 3 days, sick pig performance cough, abdominal respiration continuously, some pig expiratory dyspnea, mouth breathing, breathes sound of stridulating, respiration rate is per minute reaches 60 ~ 110 times, pig body temperature is between 39.0-40.0 DEG C, One's spirits are drooping, as aggravation of coughing after forcing its activity, in morning or the time of searching for food, also there will be cough symptom, and anorexia, part are absolutely useless.Successively have 360 pig morbidities, die of illness 2 pigs, cuts open the swelling of inspection visible sick dead pig hilar lymph node, quality is strong, in atropurpureus, and surface irregularity; There is degeneration necrosis in the lobus cardiacus of lungs and sharp leaf major part, some positions appearance color is in " shrimp carnification ", and some positions outward appearance is in " carnification ", and quality is strong, is put in water to sink.Microscopy gets lung lobus cardiacus, the lymph node smear of disease pig, and Ji's nurse Sa Albert'stain Albert can see the polymorphic thalline such as darkviolet is spherical, shaft-like, umbrella.Carry out microparticle agglutination experiment, bearing reaction is that swine enzootic pneumonia is positive.Be diagnosed as swine enzootic pneumonia.

Choose the ill pig 120 of making a definite diagnosis 8 week age, 120 ill pigs are divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and control group, the ill pig of three groups all without significant difference, has comparativity in body weight, the state of an illness etc.Embodiment group 1 uses the feed of the embodiment of the present invention 2, embodiment group 2 uses the feed of the embodiment of the present invention 3, control group uses conventional feed to feed ill pig, feed continuously 4 days, wherein, control group also needs to carry out conventional therapy namely to sick pig muscle injection kanamycins, consumption 0.2ml/kg body weight, every day 1 time, be used in conjunction 4d; Intramuscular injection tylosin 0.8ml/kg body weight, every day 1 time, is used in conjunction 4d, after 4 days, wonderful for Thailand celestial being is admixed in feed according to 500g/ head 1 week consolidate curative effect of feeding.Take each group of ill pig body weight respectively before and after experiment, calculate average daily gain and cure rate, result as shown in Table 1 and Table 2.Wherein, cure: mental restoration, diet is normal, and microparticle agglutination experiment is done in sampling, for swine enzootic pneumonia is negative.Invalid: clinical symptoms are not improved and even increased the weight of or death.

Table 1 three experimental group pig treats the average weight table of comparisons after 4 days

Group	Sum	Average weight before experiment	Average weight after test	Average daily gain
					Embodiment group 1	40	21.24kg	23.24kg	0.50kg/d
Embodiment group 2	40	21.18kg	23.74kg	0.64kg/d
					Control group	40	21.29kg	21.81kg	0.13kg/d

Data from table 1: compared with control group, use the pig of forage feed of the present invention, the pig that its average weight is fed than conventional feed exceeds 1.43kg and 1.93kg respectively, and average daily gain exceeds 0.37kg/d and 0.51kg/d respectively.

The result for the treatment of table of comparisons of table 2 three experimental group pig

Group	Sum	Recovery from illness number	Invalid number	Cure rate	Average cured time h
						Embodiment group 1	40	40	0	100%	38±3
Embodiment group 2	40	40	0	100%	24±2
						Control group	40	38	2	95%	67±4

Data from table 2: compared with conventional medicament, the feed of the embodiment of the present invention 2 has advantage that is evident in efficacy, cheap, that have no side effect in treatment swine enzootic pneumonia.

Known by contrast test: ill pig average weight, the cure rate of the mixed feed nursing of the embodiment of the present invention 2 are all better than control group, namely feed of the present invention can not only treat swine enzootic pneumonia, the nutritional need of pig can also be met, be specially adapted to the nutritional need suffering from swine enzootic pneumonia pig.

Model case

The pig that pig farm, Weifang, Shandong in December, 2012 is raised successively has 48 pig sudden onset, start as dry cough, pig coughed continuously afterwards, and some pigs occur that expiratory dyspnea, abdominal respiration, respiration rate reach 60-110 beat/min, indivedual sick temperature of pig body slightly height about 40 DEG C, wherein 3 piggys die of illness.Swine enzootic pneumonia is diagnosed as after cuing open inspection.Place is raised immediately by not occurring that the pig of symptom isolates.Choose 45 ill ill pigs, the feed of the embodiment of the present invention 3 that starts to feed, feeds 3 days, and within the 2nd day, ill pig spirit takes a turn for the better, and cough obviously alleviates, and appetite is improved, and within the 3rd day, 45 pigs are all fully recovered, and compared with health pig, average weight is substantially identical.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. a swine feed, it is characterized in that, described feed comprises following raw material: wheat, wheat bran, corn, ternip, water chestnut, Pemisetum flaccidum Griseb, pears, garlic, oat, peanut, walnut kernel, violet cabbage, dregs of beans, spinach, salt, vitamin premix and microelement pre-mix material.

2. mixed feed according to claim 1, it is characterized in that, in described feed, the parts by weight of each raw material are: wheat 50-70 weight portion, wheat bran 100-140 weight portion, corn 30-40 weight portion, ternip 15-20 weight portion, water chestnut 15-25 weight portion, Pemisetum flaccidum Griseb 15-30 weight portion, pears 10-30 weight portion, garlic 6-9 weight portion, oat 20-30 weight portion, peanut 10-15 weight portion, walnut kernel 10-20 weight portion, violet cabbage 10-20 weight portion, dregs of beans 10-30 weight portion, spinach 10-15 weight portion, salt 0.2-0.5 weight portion, vitamin premix 0.1-0.5 weight portion and microelement pre-mix material 0.1-0.5 weight portion.

3. mixed feed according to claim 1 and 2, it is characterized in that, described feed also comprises Chinese medicine additive, in described feed, the parts by weight of each raw material are: wheat 50-70 weight portion, wheat bran 100-140 weight portion, corn 30-40 weight portion, ternip 15-20 weight portion, water chestnut 15-25 weight portion, Pemisetum flaccidum Griseb 15-30 weight portion, pears 10-30 weight portion, garlic 6-9 weight portion, oat 20-30 weight portion, peanut 10-15 weight portion, walnut kernel 10-20 weight portion, violet cabbage 10-20 weight portion, dregs of beans 10-30 weight portion, spinach 10-15 weight portion, , vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 2-4 weight portion.

4. the mixed feed according to any one of claim 1-3, it is characterized in that, in described feed, the parts by weight of each raw material are: wheat 55 weight portion, wheat bran 110 weight portion, corn 35 weight portion, ternip 18 weight portion, water chestnut 21 weight portion, Pemisetum flaccidum Griseb 22 weight portion, pears 25 weight portion, garlic 7 weight portion, oat 30 weight portion, peanut 12 weight portion, walnut kernel 11 weight portion, violet cabbage 17 weight portion, dregs of beans 25 weight portion, spinach 14 weight portion, salt 0.3 weight portion, vitamin premix 0.5 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 3 weight portion.

5. the mixed feed according to any one of claim 1-4, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: stephanotis, desmodium, marginate American agave leaf, kalimeris, viola japonica, oriental wormwood, schizonepeta, tribulus terrestris, spina date seed, Radix Angelicae Sinensis, the Radix Astragali, insect wax, lingnan artocarpus fruit, bletilla, myrobalan, yellow hair purple bergenia herb, eupatorium lindleynun var. trifoliolatum, Syringa amurensis, Japanese Metaplexis Pericarp, thorny elaeagnus leaf, loguat leaf, Psoralea corylifolia, the stem of noble dendrobium, raspberry and Radix Glycyrrhizae.

6. the mixed feed according to any one of claim 1-5, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: stephanotis 7-14 weight portion, desmodium 10-15 weight portion, marginate American agave leaf 10-17 weight portion, kalimeris 10-18 weight portion, viola japonica 9-18 weight portion, oriental wormwood 10-18 weight portion, schizonepeta 15-28 weight portion, tribulus terrestris 6-11 weight portion, spina date seed 17-27 weight portion, Radix Angelicae Sinensis 17-27 weight portion, Radix Astragali 22-31 weight portion, insect wax 10-16 weight portion, lingnan artocarpus fruit 10-16 weight portion, bletilla 10-15 weight portion, myrobalan 11-17 weight portion, yellow hair purple bergenia herb 10-18 weight portion, eupatorium lindleynun var. trifoliolatum 8-15 weight portion, Syringa amurensis 7-14 weight portion, Japanese Metaplexis Pericarp 12-19 weight portion, thorny elaeagnus leaf 8-15 weight portion, loguat leaf 12-20 weight portion, Psoralea corylifolia 15-25 weight portion, stem of noble dendrobium 12-19 weight portion, raspberry 18-26 weight portion and Radix Glycyrrhizae 10-18 weight portion.

7. the mixed feed according to any one of claim 1-6, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: stephanotis 13 weight portion, desmodium 11 weight portion, marginate American agave leaf 12 weight portion, kalimeris 15 weight portion, viola japonica 13 weight portion, oriental wormwood 14 weight portion, schizonepeta 22 weight portion, tribulus terrestris 9 weight portion, spina date seed 25 weight portion, Radix Angelicae Sinensis 26 weight portion, the Radix Astragali 30 weight portion, insect wax 11 weight portion, lingnan artocarpus fruit 12 weight portion, bletilla 10 weight portion, myrobalan 14 weight portion, yellow hair purple bergenia herb 16 weight portion, eupatorium lindleynun var. trifoliolatum 12 weight portion, Syringa amurensis 11 weight portion, Japanese Metaplexis Pericarp 16 weight portion, thorny elaeagnus leaf 12 weight portion, loguat leaf 18 weight portion, Psoralea corylifolia 21 weight portion, the stem of noble dendrobium 15 weight portion, raspberry 21 weight portion and Radix Glycyrrhizae 14 weight portion.

8. the mixed feed according to any one of claim 1-7, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:

The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains Chinese medicine additive powder.

9. the preparation method of the mixed feed according to any one of claim 1-8, is characterized in that, described preparation method comprises the following steps:

(1) destruction step: take wheat, wheat bran, corn, ternip, water chestnut, Pemisetum flaccidum Griseb, pears, garlic, oat, peanut, walnut kernel, violet cabbage, dregs of beans and spinach by ratio of weight and the number of copies, drop into pulverizer and carry out Crushing of Ultrafine, after pulverizing, cross 2.0mm sieve;

(2) batching step: take the described raw material of residue according to ratio of weight and number, pulverize the fine powder obtained mix with step (1), drop into mixer, mix, incorporation time is 30-60s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.