CN111991540A - Traditional Chinese medicine composition for treating hepatic fibrosis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating hepatic fibrosis and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hepatic fibrosis, a preparation method and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-100 parts of rhizoma alismatis, 5-30 parts of thunberg fritillary bulb, 5-30 parts of peach kernel, 5-20 parts of salvia miltiorrhiza, 5-30 parts of red paeony root, 5-30 parts of radix curcumae, 10-40 parts of fried rice sprout, 10-40 parts of fried malt, 5-20 parts of cynanchum glaucescens, 5-30 parts of pepper, 1-5 parts of changium smyrnioides, 1-10 parts of rice lily, 5-15 parts of bamboo shavings, 1-5 parts of red yeast rice, 1-10 parts of pollen typhae, 0.5-2 parts of water chestnut, 0.1-2 parts of sedum pratense root, 0.1-2 parts of negundo chastetree fruit, 1-3 parts of common bluegrass, 5-40 parts of adenophora tetraphylla, 2-30 parts of loquat leaf, 1-20 parts of fritillary bulb, 1-10 parts of walnut, 1-30 parts of cordyceps sinensis, 1-10 parts of golden cypress, 1-5 parts of trichosanthes kirilowii maxim, 10-100 parts of ulva, 5-50 parts of rhizoma anemarrhenae and 5-30 parts of Chinese date. The invention has obvious curative effect of treating hepatic fibrosis; meanwhile, the formula of the invention does not contain any chemical additive, and the invention has safe and reliable taking and no toxic or side effect.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method and application thereof, belonging to the technical field of pharmacy.
Background
Hepatic fibrosis is a pathophysiological process, which refers to abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Any liver injury has liver fibrosis in the process of liver repair and healing, and if the injury factor cannot be removed for a long time, the fibrosis process can be continuously developed into liver cirrhosis for a long time.
There are many causes of hepatic fibrosis, and viral hepatitis, alcoholic liver, fatty liver, autoimmune diseases, etc. are common in clinic. Anti-hepatic fibrosis treatment mainly comprises: removing pathogenic factors aiming at the primary disease, such as anti-hepatitis B and hepatitis C virus therapy, anti-schistosomiasis therapy, alcohol withdrawal and the like. The treatment aiming at the hepatic fibrosis is carried out, for example, by inhibiting inflammation or lipid peroxidation, or inhibiting the proliferation and activation of hepatic stellate cells, promoting the degradation of collagen and the like.
At present, most of anti-hepatic fibrosis treatments on the market are targeted means formed by aiming at specific causes, hepatic fibrosis has no particularly obvious clinical symptoms strictly speaking, and mainly has clinical symptoms of hepatitis caused by damage of the liver by various factors or further aggravation of liver cirrhosis, so that the existing technologies or medicines are difficult to treat or prevent hepatic fibrosis, and therefore, the search of safe and effective medicines for treating hepatic fibrosis in traditional Chinese medicines is urgently needed.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method and application thereof. The invention has obvious curative effect of treating hepatic fibrosis; meanwhile, the formula of the invention does not contain any chemical additive, and the invention has safe and reliable taking and no toxic or side effect.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a traditional Chinese medicine composition for treating hepatic fibrosis is prepared from the following raw material medicines in parts by weight: 10-100 parts of rhizoma alismatis, 5-30 parts of thunberg fritillary bulb, 5-30 parts of peach kernel, 5-20 parts of salvia miltiorrhiza, 5-30 parts of red paeony root, 5-30 parts of radix curcumae, 10-40 parts of fried rice sprout, 10-40 parts of fried malt, 5-20 parts of cynanchum glaucescens, 5-30 parts of pepper, 1-5 parts of changium smyrnioides, 1-10 parts of rice lily, 5-15 parts of bamboo shavings, 1-5 parts of red yeast rice, 1-10 parts of pollen typhae, 0.5-2 parts of water chestnut, 0.1-2 parts of sedum pratense root, 0.1-2 parts of negundo chastetree fruit, 1-3 parts of common bluegrass, 5-40 parts of adenophora tetraphylla, 2-30 parts of loquat leaf, 1-20 parts of fritillary bulb, 1-10 parts of walnut, 1-30 parts of cordyceps sinensis, 1-10 parts of golden cypress, 1-5 parts of trichosanthes kirilowii maxim, 10-100 parts of ulva, 5-50 parts of rhizoma anemarrhenae and 5-30 parts of Chinese date.
The traditional Chinese medicine composition for treating hepatic fibrosis is prepared from the following raw material medicines in parts by weight: 15-50 parts of rhizoma alismatis, 10-20 parts of thunberg fritillary bulb, 5-20 parts of peach kernel, 5-15 parts of salvia miltiorrhiza, 5-15 parts of red paeony root, 5-15 parts of radix curcumae, 12-18 parts of fried rice sprout, 12-17 parts of fried malt, 5-15 parts of cynanchum glaucescens, 10-25 parts of pepper, 2-4 parts of changium smyrnioides, 2-8 parts of rice lily, 8-13 parts of bamboo shavings, 1-3 parts of red yeast rice, 1-5 parts of cattail pollen, 0.5-1 part of water chestnut, 0.1-1 part of sedum pratense, 0.1-1 part of negundo chastetree fruit, 1.5-2.5 parts of common bluebeard herb, 5-20 parts of adenophora tetraphylla, 5-15 parts of loquat leaf, 1-15 parts of illipe, 5-8 parts of walnut, 10-20 parts of cordyceps sinensis, 3-8 parts of golden broccoli, 2.5-3.5 parts of trichosanthes kirilowii maxim, 10-50 parts of ulva, 5-20 parts of rhizoma anemarrhenae and 10-20 parts of Chinese date.
The traditional Chinese medicine composition for treating hepatic fibrosis is prepared from the following raw material medicines in parts by weight: 30 parts of rhizoma alismatis, 15 parts of thunberg fritillary bulb, 10 parts of peach kernel, 10 parts of salvia miltiorrhiza, 10 parts of red paeony root, 10 parts of radix curcumae, 15 parts of fried rice sprout, 15 parts of fried malt, 10 parts of cynanchum glaucescens, 20 parts of zanthoxylum bungeanum maxim, 3 parts of changium smyrnioides, 6 parts of rice lily, 10 parts of bamboo shavings, 2 parts of red yeast rice, 2 parts of pollen typhae, 0.8 part of water chestnut, 0.5 part of sedum aizoon, 0.5 part of negundo chastetree, 2 parts of bluegrass, 10 parts of adenophora tetraphylla, 10 parts of loquat leaf, 8 parts of fritillary bulb, 6 parts of walnut, 15 parts of cordyceps sinensis, 5 parts of golden broccoli, 3 parts of trichosanthes kirilowii maxim, 12 parts of orange peel.
The preparation method of the traditional Chinese medicine composition for treating hepatic fibrosis comprises the following steps:
(1) pulverizing Alismatis rhizoma, Bulbus Fritillariae Thunbergii, semen Persicae, radix Changii, Bulbus Lilii, radix Adenophorae, Juglandis, Cordyceps, fructus Trichosanthis, rhizoma anemarrhenae and fructus Jujubae, and sieving with 40-60 mesh sieve to obtain fine powder;
(2) extracting Saviae Miltiorrhizae radix, radix Paeoniae Rubra, radix Curcumae, fructus oryzae Preparata, fructus Hordei Germinatus Preparata, rhizoma Cynanchi Stauntonii, semen Zanthoxyli, caulis Bambusae in Taenia, Monascus purpureus went, pollen Typhae, corm Eleocharitis, radix Desmodii Styracifolii, fructus Viticis negundo, herba Eupatorii, folium Eriobotryae, Bulbus Fritillariae Pallidii, radix Lysimachiae Fortunellae, pericarpium Citri Junoris, herba Lycopi, and Ulva with 9-12 times of deionized water for 4-6 times, each for 1.5-2.5 hr, filtering, concentrating the filtrate, drying, pulverizing the solid obtained after drying to obtain water extract;
(3) mixing the fine powder and water extract, mixing with medicinal adjuvants, and making into oral preparation by conventional method.
The application of the traditional Chinese medicine composition in preparing the medicine for treating hepatic fibrosis is provided.
According to the traditional Chinese medicine composition for treating hepatic fibrosis, the dosage form of the traditional Chinese medicine composition is hard capsules, soft capsules, tablets, granules, powder, pills, tea bags or water decoction.
The fine crushing specifically comprises the steps of putting the raw materials in the step (1) into a freeze dryer, freezing for 4 hours at-55 ℃, taking out the raw materials to naturally melt for 50min, putting the raw materials into the freeze dryer again, freezing for 4 hours at-55 ℃, taking out the raw materials to naturally melt for breaking the cell walls of the raw materials, then putting the raw materials into a planetary ball mill, grinding for 50-55min at 240r/min, wherein the medium filling rate of the planetary ball mill is 27%, and the filling rate of the crushed raw materials is 19%.
The traditional Chinese medicine composition disclosed by the invention is based on the treatment concept of reducing phlegm and removing stasis, the treatment of hepatic fibrosis follows the treatment of acute symptoms and slow symptoms, the treatment of early symptoms is mainly based on deficiency of vital qi and excessive phlegm stasis, and the treatment of acute symptoms and slow symptoms is preferably based on the treatment of acute symptoms and slow symptoms.
The pharmacological actions of the raw material medicines are as follows:
alisma orientale, school name: alisma plantago-aquatica Linn, perennial aquatic or marsh grass. Can be used for treating nephritis, edema, pyelonephritis, enteritis, diarrhea, dysuresia, etc. In the book of materia medica Zhengyi, ze Xie is best in draining water passage and specially for passing urine, and can promote phlegm and fluid retention, for instance, in the book of materia Medica, it is said that it can induce phlegm to resolve into fluid retention, but phlegm and fluid retention also accumulates water and stops dampness, so it can induce diuresis and resolve phlegm. Modern researches show that rhizoma alismatis has a protective effect on liver, lipid-soluble part of rhizoma alismatis has an obvious cholesterol-lowering effect and an anti-atherosclerosis effect on experimental hypercholesteremia rabbits, and the separated acetate of the alisol A, B and the alisol A, B, C have the obvious cholesterol-lowering effect except for the alisol B. When added into the feed of experimental hyperlipoidemia mice in an amount of 0.1%, the feed can reduce blood cholesterol by more than 50%, wherein alisol A-24-acetate has the strongest effect. The ethanol extract of the alisma orientale, the ethyl acetate extract of the ethanol extract and the like have the effect of reducing blood fat for experimental hypercholesteremia rabbits and mice. The ethyl acetate extract and its residual insoluble in acetic acid-water are most effective. The ethyl acetate extract is orally taken at a dose of 1g/kg per day, and has obvious cholesterol lowering effect on normal mice fed with common feed. The orthotopic marking method proves that alisol A has the capacity of inhibiting the esterification of cholesterol in small intestines of mice, and can reduce the absorption rate of cholesterol in the small intestines of the mice by 34 percent without influencing the absorption of linoleic acid. Reducing cholesterol can reduce liver burden, and prevent hepatic fibrosis and liver cirrhosis.
The Bulbus Fritillariae Thunbergii is dried bulb of Fritillaria thunbergii Miq. Zhejiang fritillaria is bitter and cold in property, can clear heat and resolve phlegm, especially has remarkable effects of relieving depression and dissipating stagnation, is a common medicine for treating scrofula, sore and carbuncle swelling toxin, and has the effects of clearing heat, resolving phlegm, relieving cough, detoxifying, resolving masses and resolving carbuncle. The combination of alisma rhizome and thunberg fritillary bulb can dispel phlegm-damp and disperse phlegm stagnation.
Peach kernel is dry mature seed of Prunus persica (L.) Batsch or Prunus davidiana (Carr.) Franch of Rosaceae, and has effects of promoting blood circulation, removing blood stasis, resolving carbuncle, expelling pus, loosening bowel, and relieving constipation. It is good at entering heart and liver blood system, activating blood and unblocking meridians, removing stasis and alleviating pain, and can be used for obstruction of blood stasis and mass accumulation due to unsmooth blood flow. The "pharmacy records" are: peach kernel, semen Persicae, bitter in flavor, can purge blood heat, moisten body and nourish intestinal dryness. If the Lian Pi is smashed for multiple purposes, it can break and store blood, dispel water, induce pain, numbness of limbs, hemiplegia and pain of feet, so it can promote blood circulation, remove blood stasis and promote tissue regeneration. Getting up without oneself: liver is the source of blood, blood accumulation causes dryness of liver qi, bitter and urgent liver, and urgent and sweet food is treated by slow action. Tao ren is sweet in flavor and acts as a liver-soothing and blood-dissipating herb. The book of thought differentiation of materia Medica: tao ren is a liver herb for dispelling blood stasis and also has the action of dispersing skin and striae.
The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia milithiorrhiza bge of Labiatae, and has bitter taste, slightly cold property, and heart and liver meridian tropism. Has the effects of promoting blood circulation, removing blood stasis, stimulating the menstrual flow, relieving pain, clearing away the heart-fire, relieving restlessness, cooling blood, eliminating carbuncle, promoting blood circulation, treating dysmenorrhea, removing blood stasis and relieving pain. The record in Shen nong Ben Cao Jing: "bitter in taste and slightly cold in nature" is mainly indicated for … … accumulation, mass breaking and mass removing. The "materia medica justice" also states: dan Shen is specialized in blood system and has the actions of activating blood and promoting blood circulation, and removing blood stasis and stagnation by reaching viscera. The "materia medica summary" records: dan Shen is also indicated for blood system, removing stagnation and promoting tissue regeneration, regulating menstruation and regulating pulse.
Radix Paeoniae Rubra is dry root of Ranunculaceae plant radix Paeoniae Rubra or radix Paeoniae Rubra, is bitter and slightly cold, and has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis; for example, it is recorded in Ben Cao Jing Shu (herbal Jing Shu): the red-colored and broken-powder of mu Shao is mainly used for relieving pain and is specialized in blood system of liver and home, so it is mainly used for abdominal pain due to pathogenic qi. It is mainly used for removing blood impediment and dissipating hard mass, blood stasis causes cold and heat, blood circulation causes cold and heat self-stopping, blood impediment and hernia are all formed by blood coagulation stagnation, and blood stagnation of limbs causes impediment and hernia self-elimination. Cool the liver to dredge the blood vessels, the liver governs blood and enters the liver to promote blood circulation, so disperse blood stasis and expel blood stasis.
The radix Curcumae is dried root tuber of Curcuma wenyujin Y, H, Chenet C.Ling, Curcuma longa longal, Curcuma kwangsiensis S.G.Lee et C.F.Liang or Curcuma zedoaria alpha eocaulis Val of Zingiberaceae; yu jin is the qi-flowing herb in blood, not only activating blood and alleviating pain, but also moving qi, and also has the actions of promoting bile flow and removing jaundice, cooling blood and stopping bleeding. Its pungent flavor can disperse energy and move, and can activate blood circulation to dissipate blood stasis, and move qi and relieve depression to alleviate pain, as recorded in the book Ben Cao Hui Yan: yu jin is also indicated for clearing qi and resolving phlegm, and dissipating blood stasis. It is mild in nature, can dispel stasis, direct adverse qi, ascends to the vertex, and is good at moving the lower energizer, and is the most suitable for patients with stagnation of qi, blood, and phlegm in the heart, lung, liver, stomach, and stomach, so it is indicated for chest and stomach pain, distending fullness in the hypochondrium, pain attacking the abdomen, and poor appetite. The book Ben Cao Jing Yi: yu jin, bitter and cold in flavor, means that qi is cold and descending well, and bitter and purging well. For those with blood stasis, the main reason is that the pathogen is blood accumulation, especially has the effect of breaking the malignant blood, because the pathogen is blood accumulation, the blood is accumulated, the blood is malignant blood, the blood flows upwards reversely, and comes out from mouth and nose, the blood is epistaxis and hematemesis, the blood flows downwards, and comes out from urinating and defecating, the pain is stranguria with blood, and the pain is hematuria, i.e. the blood stasis of incised wound is not removed, the blood is not broken, and the tissue regeneration cannot be promoted.
The parched rice sprout is mature fruit of millet of Gramineae, processed to sprout, and parched; has the effects of treating indigestion, fullness, diarrhea and anorexia.
The roasted malt is also called barley malt, barley \31989, barley \31989and barley wool, and is mainly used for treating indigestion, abdominal distending pain, spleen deficiency and poor appetite, milk sweat and stasis, breast distending pain and breast weaning of women; modern research shows that roasted malt contains alpha and beta amylase; starch is a mixture of sugar starch and gum starch, the glucose molecules that make up the sugar starch are linked by alpha-1, 4 glycosidic linkages and are in a linear arrangement. The glue starch is formed by cross arrangement of a plurality of short straight chain polyglucose. Amylopectin molecules have alpha-1, 6 glucosidic bonds in addition to alpha-1, 4 glucosidic bonds. Alpha and beta amylases can hydrolyze alpha-1, 4 glycosidic bonds and have no effect on alpha-1, 6 glycosidic bonds. Beta-amylase is able to hydrolyze the sugar starch completely to maltose, and alpha-amylase breaks it down to short direct bond polyglucose (i.e., dextrin), which in turn is able to hydrolyze the beta-amylase to maltose. Starch can thus be broken down into maltose and dextrin by the action of alpha and beta amylases. The malt decoction has a slight promoting effect on the secretion of gastric acid and pepsin. The roasted malt also has the function of reducing blood sugar, and the 5 percent injection prepared by the refined product of malt residue water extraction and alcohol precipitation is injected into rabbits for 200mg, so that the blood sugar can be reduced by 40 percent or more, and the recovery is mostly realized after 7 hours.
White anterior, alias: common turnip leaf, rhizoma cynanchi, cough medicine, herba dianthi chinensis, herb of linearstripe rabdosia herb, herb of common rabdosia, Latin, the name: cynanchum glaucescens (Decne.) hand-Mazz has effects of purging lung, lowering qi, eliminating phlegm, relieving cough, and promoting hemoptysis. Modern researches show that rhizome of cynanchum glaucescens contains beta-sitosterol which has the effects of reducing cholesterol, relieving cough, eliminating phlegm, inhibiting tumor and repairing tissue; can be used for treating type II hyperlipidemia, atherosclerosis and chronic tracheitis, and early stage cervical cancer and skin ulcer. .
Zanthoxylum seed, herbaceous plants are multi-branched, dry seeds are oval or spherical, and have the effects of inducing diuresis to alleviate edema, eliminating phlegm and relieving asthma, and modern researches show that: the zanthoxylum alcohol extract has the effect of relieving cough for mice with cough induced by ammonia water and guinea pigs with cough caused by citric acid. The zanthoxylum bungeanum maxim aqueous extract does not have the function of relieving cough. The zanthoxylum bungeanum ethanol extract and the zanthoxylum bungeanum aqueous extract have the effect of relieving asthma of guinea pig caused by histamine by intragastric administration. The ethanol extract is used for gastric lavage to inhibit the acute allergic bronchospasm of guinea pigs caused by egg albumin liquid.
The root of Changium smyrnioides Wolff, radix codonopsis pilosulae, radix pseudostellariae, paniculate swallowwort root, radishes, radix adenophorae and Changium smyrnioides Wolff of umbelliferae has the effects of moistening lung, reducing phlegm, nourishing yin, harmonizing stomach, calming liver and detoxifying, and pharmacological research shows that the product has the effects of eliminating phlegm, relieving cough and asthma and has the effects of regulating blood fat, resisting oxidation and resisting stress; the composition has the effect of promoting the small intestine peristalsis of normal mice, contains volatile oil, wherein the volatile oil contains more than 50 compounds, 10 components are identified, and the methyl 6, 9-octadecadienoate with the highest content is considered as an effective component for moistening lung and reducing phlegm; also contains more than 20 amino acids and 18 trace elements; l-asparagine is an effective component for relieving cough and asthma.
The rice lily, the heavy mai, the lily garlic and the garlic are fleshy scaly leaves of a Lilium longiflorum Thunb, a plant of the family of the cephalosporaceae, have the effects of nourishing yin, moistening the lung, clearing away the heart fire and soothing the nerves, and the results of modern pharmacological tests show that the water decoction has the function of relieving cough of mice caused by ammonia water, so that the lung perfusion flow of the mice is increased. In addition, it also has antitussive, antiasthmatic, expectorant effects; resistance to stress injury; tranquilizing and hypnotizing; enhancing immune function; the effect of increasing peripheral leukocytes, and the like.
Caulis Bambusae in Taenia, a dry intermediate layer in the stalk of Phyllostachys nigra (Lodd.) Munro var. henonis (Mitf.) Stapf ex Rendle of Gramineae, has sweet and slightly cold properties. It enters lung and stomach meridians. Clearing heat, eliminating phlegm, relieving restlessness and relieving vomit, and can be used for treating phlegm-heat cough, gallbladder fire with phlegm, dysphoria with smothery sensation and emesis, palpitation and insomnia, apoplexy with phlegm, aphasia, intense tongue, stomach heat emesis, vomiting, pregnancy pernicious vomiting, and threatened abortion.
Red yeast, namely red yeast, red rice, green yeast, red rice and red tank, is prepared by inoculating Monascus purpureus Went, a fungus of Monascus family, onto steamed kernels of japonica rice of gramineae, and fermenting to form hypha, and has the effects of promoting blood circulation to remove blood stasis, strengthening spleen and helping digestion, and pharmacological research shows that the red yeast has better effect of reducing blood pressure for patients with low renin and hypertension; red rice can produce antibacterial active substance, has antibacterial activity on Bacillus, Streptococcus, Pseudomonas, etc., and its antibacterial activity is produced by two pigments of Mengna rubine and Pandamine. The monascus fermented can be separated into coenzyme Q10, coenzyme Q10 is also called as decene quinone, is an activator of cell metabolism and cell respiration, and can improve mitochondrial respiration function and promote oxidative phosphorylation reaction. It is also a natural oxidant produced by cells, can inhibit the peroxidation of mitochondria and has the function of protecting the structural integrity of biological membranes. Has nonspecific enhancing effect on immunity, and can increase phagocytic rate of phagocyte, increase antibody production, and improve T cell function.
Cattail pollen, also known as cattail pollen, cattail pollen and cattail centi pollen, is pollen of Typha angustifoliaal, a typhaceae plant, and has the effects of stopping bleeding, removing blood stasis and treating stranguria.
Water chestnut, the bulb and aerial part of the trin.ex Henschel of Eleocharis dulcis (burm.f.) of chufa genus of cyperaceae family, has the efficacies of clearing heat and quenching thirst, removing dampness and reducing phlegm and lowering blood pressure, and is used for treating fever and impairment of body fluid, polydipsia, sore throat, stomatitis, damp-heat jaundice, hypertension, dysuresia, measles, lung-heat cough, silicosis and haemorrhage, and the record of the compendium of materia medica: "treating five kinds of accumulation according to Wang Shi's Boji Fang, cold air attacking heart and turning into five kinds of diaphragm diseases, black burreed rhizome is used in Jinsuo pills and injected into Yun: namely brick, wanli, entitled "debulking", hereby incorporated by reference. "
Digitalis asiatica root, which is the whole herb of Asplenium proliferum hook, belonging to the family of ferula, has the effects of clearing heat and removing dampness, promoting blood circulation and removing blood stasis, relieving cough and reducing sputum, and inducing diuresis and promoting lactation, and is commonly used for treating rheumatic pain, enteritis, dysentery, urinary tract infection, cough and excessive phlegm, traumatic injury, hematemesis, metrorrhagia and galactostasis; it is used externally to treat fracture and traumatic hemorrhage; the record of Zhejiang medical plant records: for acute icteric hepatitis: 45g of fournisetum flaccidum, Chinese brake herb, selaginella tamariscina and canthus ferox are decocted in water for oral administration. "
The vitex negundo L, also called fructus viticis and fructus aurantii, is a fruit of Viter negundo L, a plant of Verbenaceae, has the effects of dispelling wind, relieving exterior syndrome, eliminating phlegm, relieving cough, promoting qi circulation and relieving pain, and pharmacological studies show that the water decoction has an inhibiting effect on staphylococcus aureus and catacoccus in a test tube.
The orchid is Cymbidium ensifolium (L.) Swartz, Cymbidium floribundum Lindl [ C. pumium Rolfe ] and Cymbidium goeringii [ C. virescens Lindl ] of orchidaceae, and is applied by root or whole herb, has the efficacies of nourishing yin, clearing away the lung-heat, reducing phlegm and relieving cough, and is used for whooping cough, tuberculosis cough, hemoptysis, neurasthenia, dizziness, urinary tract infection and leucorrhea.
The Adenophora tetraphylla, namely Adenophora tetraphylla, rhizoma anemarrhenae, Adenophora alba, ginseng, paniculate swallowwort root and will extract, is a dry root of Adenophora tetraphylla (Thunb.) Fisch or Adenophora stricta Miq. of a platycodonaceae plant, has the effects of nourishing yin, clearing away the lung-heat, tonifying stomach, promoting the production of body fluid, reducing phlegm and tonifying qi, and pharmacological research shows that the Adenophora tetraphylla has the function of regulating immune balance and has the functions of eliminating phlegm, resisting fungi and strengthening heart.
Loquat leaves, which are leaves of loquat Eriobotrya japonica (Thunb.) Lindl of the genus Eriobotrya of the family Rosaceae, have the effects of clearing lung-heat, relieving cough, harmonizing stomach, lowering adverse qi and quenching thirst, and are mainly used for treating lung heat phlegm cough, yin deficiency over-strained cough, hemoptysis, epistaxis, hematemesis, stomach heat vomitus, vomiting of pregnancy, infantile vomiting of milk, thirst quenching and lung wind and facial sore. Pharmacological research shows that the medicine has the functions of relieving asthma, relieving cough and reducing blood sugar.
Fritillaria pallidiflora Schrenk or Fritillaria waLujewii Re-gel, which is a bulb of Fritillaria pallidiflora Schrenk or Fritillaria waLujewii Re-gel, belonging to Liliaceae, has the effects of clearing heat, moistening lung, reducing phlegm and relieving cough, and clinical application shows that the traditional Chinese medicine composition is used for treating cough with lung heat, dry cough with little phlegm, cough with yin deficiency and bloody expectoration.
Walnut, commonly known as walnut, has the effects of breaking blood and removing stasis, moistening dryness and lubricating intestines, is used for treating amenorrhea due to blood stagnation, blood stasis and abdominal pain, blood accumulation and mania, traumatic injury and blood stasis and other diseases, and can be used for relieving constipation caused by intestinal dryness. Walnut, bitter in flavor, has the actions of purging and dissipating blood stasis, entering the blood system of liver meridian, and strongly activating blood and regulating menstruation, and removing blood stasis and promoting tissue regeneration, and is suitable for patients with severe blood stasis. In addition, it has the actions of moistening intestines and relieving cough.
Cordyceps sinensis (Berk.) Sacc is a complex of stroma of Cordyceps sinensis (L.) belonging to Clavicipitaceae and larva of Cordyceps sinensis (Hepialidae) which is host of Hepialidae insect (Hepialidae). The cordyceps sinensis can improve the liver function of a patient, relieve inflammatory cell infiltration and hepatocyte degeneration necrosis of the liver, and has stronger effect of promoting hepatocyte repair by cordyceps sinensis hypha; the Cordyceps Polysaccharide Liposome (CPL) has a certain protection effect on liver tissues damaged by CCl 4; the Cordyceps aqueous solution can inhibit proliferation of hepatic lipid storage cells, and can also inhibit transformation of hepatic lipid storage cells into myofibroblasts and fibroblasts.
Jinjinxiang, a kind of plant Jinjinxiang Osbeckia chinensis L of Jinjinxiang of Melastomataceae, is used as medicine with whole herb, has the functions of clearing away heat and promoting diuresis, eliminating swelling and detoxicating, relieving cough and eliminating phlegm, and is used in treating acute bacillary dysentery, amebic liver abscess, enteritis, cold cough, swelling and pain in throat, children's bronchial asthma, pulmonary tuberculosis hemoptysis, appendicitis, venomous snake bite, furuncle and furuncle.
Trichosanthes kirilowii, namely medicinal melons, tripe melons, big tripe melons and duck dung melons, are fruits of Trichosanthes kirilowii Maxim and Trichosanthes rosthornii Harms which are Cucurbitaceae plants, have the effects of clearing heat, reducing phlegm, widening chest, eliminating stagnation, moistening dryness and lubricating intestines, and are used for treating lung heat cough, thoracic obstruction, carbuncle, thirst, constipation and swelling and sore toxin; pharmacological studies show that it can dilate the coronary artery; anti-myocardial ischemia; improving microcirculation; inhibiting platelet aggregation; hypoxia tolerance; anti-arrhythmic; anti-ulcer; antibacterial; resisting cancer; and (4) resisting aging.
Orange peel, namely orange peel, has the effects of promoting qi circulation, reducing phlegm, lowering adverse qi, promoting digestion, regulating stomach function, promoting health, killing fish and crab toxin, and is mainly used for treating chest and diaphragm qi stagnation, cough with excessive phlegm, indigestion, nausea and vomiting; pharmacological studies show that it can regulate the digestive system; exciting heart, enhancing myocardial contraction force, inhibiting heart rate due to excessive dosage, and increasing coronary blood flow; has certain prevention effect on arteriosclerosis caused by high fat diet; relieving asthma and eliminating phlegm; the renal blood vessels are contracted, and the urine volume is reduced; inhibiting in vitro uterus, and relaxing uterus at high concentration; enhancing immune function; anti-inflammatory; the bleeding and blood coagulation time is shortened; can promote secretion of digestive juice such as saliva and gastric juice, and eliminate intestinal gas accumulation.
Eupatorium Chinese, Eupatorium Chinese L. of Compositae, has effects of clearing away heat and toxic materials, dispersing stagnated liver qi, and promoting blood circulation. Can be used for treating wind-heat type common cold, chest and hypochondriac pain, abdominal pain and distention, traumatic injury, carbuncle, swelling, sore, and snake bite. The records in Fujian medicine record are as follows: soothing liver and relieving depression, opening chest and benefiting diaphragm, regulating menstruation and promoting blood circulation, and relieving swelling and pain. Can be used for treating common cold, chest and costalgia, gastralgia, abdominal distention, puerperal edema, puerperal blood stasis and pain, menoxenia, rheumatic arthralgia, traumatic injury, snake bite, and ecthyma.
Ulva lactuca L.of Ulva lactuca of Ulvaceae, Ulva pertusa Kjellm.and Ulva fasciata Delile. Has the effects of inducing diuresis to alleviate edema, softening hard masses, reducing phlegm, clearing heat and removing toxicity. Used for edema, swelling of cervical lymph nodes, goiter, hypertension, laryngitis, sore, furuncle, acute and chronic gastroenteritis, and infantile malnutrition; pharmacological research shows that the compound has coagulation and negative muscle force effects.
Rhizoma anemarrhenae, dried rhizome of Anemarrhena asphodeloides Bunge of Liliaceae, has effects of clearing heat-fire, nourishing yin and moistening dryness, and can be used for treating fever polydipsia, lung heat dry cough, bone steaming hectic fever, internal heat diabetes, intestinal dryness and constipation; the "materia medica justice" records: zhi mu is cold and moist, so it is indicated for excess fire, purging lung to purge obstruction heat, lung abscess and dry cough, while deficiency heat cough is contraindicated. Clearing stomach heat is indicated for rescuing body fluids, while spleen-qi is contraindicated for fever in middle energizer. It is indicated for the syndrome of pathogenic fire in the early stage of stranguria due to pathogenic heat, and is used as a marker for strengthening yang and preventing atrophy. The heat disease is manifested by yangming, polydipsia, profuse sweating, surging and interior heat, accompanied by gypsum to eliminate inflammation; malaria syndrome is manifested as excessive sweating and heat due to damp turbidity fumigation, and spleen heat is relieved by Zuo Cao. For the specific indications, there are the remaining four characters without excessive heat. "
The Chinese date is a mature fruit of the Rhamnaceae plant Chinese date, and has the following main functions: invigorating spleen and regulating stomach function, benefiting qi and promoting fluid production, regulating yingfen and weifen, and removing drug toxicity. It is indicated for deficiency of stomach and food, spleen weakness, loose stool, qi, blood and body fluids deficiency, disharmony between ying and wei, palpitation. The traditional Chinese medicine composition has the effects of resisting tumor and I-type allergic reaction in pharmacological research and inhibiting central nerves, can reduce the level of serum glutamic-pyruvic transaminase in clinical tests, and is effective for patients with acute and chronic hepatitis and cirrhosis patients who have high serum transaminase activity by taking 1 dose of red date peanut soup (red date, peanut and rock candy respectively 1 time and decocting the peanut firstly and then adding red date rock candy) before sleeping at night for 30 days as a treatment course and observing 12 cases.
Compared with the prior art, the traditional Chinese medicine composition creatively takes the rhizoma alismatis as the main medicine of the traditional Chinese medicine composition, achieves the effects of eliminating phlegm dampness and dissipating phlegm stagnation with the thunberg fritillary bulb, is added with the peach kernel, the salvia miltiorrhiza, the red paeony root and the radix curcumae for combining and removing blood stasis, is prepared by adding 25 medicinal materials such as fried rice sprout, fried malt and cynanchum glaucescens and is prepared by mixing. For the "dark stasis stage" of hepatic fibrosis, it is indicated for phlegm stasis, mainly in liver, spleen and liver. The invention is characterized in that the dampness-removing and phlegm-resolving medicine and the blood-activating and stasis-removing medicine are used together, and the invention is specially designed for the liver fibrosis phlegm-stasis type. Meanwhile, the components in the formula of the invention do not contain any chemical additive, and the invention has safe and reliable taking and no toxic or side effect.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1: a traditional Chinese medicine composition for treating hepatic fibrosis is prepared from the following raw material medicines in parts by weight: 50g of rhizoma alismatis, 15g of thunberg fritillary bulb, 15g of peach kernel, 20g of salvia miltiorrhiza, 8g of red paeony root, 20g of radix curcumae, 35g of fried rice sprout, 35g of fried malt, 10g of cynanchum glaucescens, 30g of bunge pricklyash seed, 1g of changium smyrnioides, 8g of rice lily, 10g of bamboo shavings, 2g of red yeast rice, 5g of pollen typhae, 1g of water chestnut, 0.5g of radix sedi, 0.5g of negundo chastetree, 3g of common bluegrass, 25g of adenophora tetraphylla, 30g of loquat leaf, 15g of fritillaria pallidiflora, 1g of walnut, 25g of cordyceps sinensis, 5g of golden broccoli, 2g of trichosanthes kirilowii maxim, 15g of orange peel, 2 g.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) mixing and crushing rhizoma alismatis, thunberg fritillary bulb, peach kernel, changium smyrnioides, lilium brownii, adenophora tetraphylla, walnut, cordyceps sinensis, trichosanthes kirilowii maxim, rhizoma anemarrhenae and Chinese date, wherein the crushing process is specifically that the raw materials are firstly placed in a freeze dryer, frozen for 4 hours at the temperature of minus 55 ℃, then taken out to be naturally melted for 50 minutes, and then placed in the freeze dryer again to be frozen for 4 hours at the temperature of minus 55 ℃, then taken out to be naturally melted for breaking the cell wall of the raw materials, and then the raw materials are ground for 50-55 minutes in a planetary ball mill at 240r/min, wherein the medium filling rate of the planetary ball mill is 27%, the filling rate of the crushed raw materials is 19%, and the crushed raw materials are sieved by a 40-mesh;
(2) extracting Saviae Miltiorrhizae radix, radix Paeoniae Rubra, radix Curcumae, fructus oryzae Preparata, fructus Hordei Germinatus Preparata, rhizoma Cynanchi Stauntonii, semen Zanthoxyli, caulis Bambusae in Taenia, Monascus purpureus went, pollen Typhae, corm Eleocharitis, radix Desmodii Styracifolii, fructus Viticis negundo, herba Eupatorii, folium Eriobotryae, Bulbus Fritillariae Pallidii, radix Lysimachiae Fortunellae, pericarpium Citri Junoris, herba Lycopi, and Ulva with 9-12 times of deionized water for 4-6 times, each for 1.5-2.5 hr, filtering, concentrating the filtrate, drying, pulverizing the solid obtained after drying to obtain water extract;
(3) mixing the fine powder and the water extract, mixing with pharmaceutical adjuvants, and making into pill of 0.2 g/pill by conventional method: the preparation is administered three times a day, 20-40 granules each time, for 2 months.
Example 2: a traditional Chinese medicine composition for treating hepatic fibrosis is prepared from the following raw material medicines in parts by weight: 40g of rhizoma alismatis, 30g of thunberg fritillary bulb, 25g of peach kernel, 10g of salvia miltiorrhiza, 15g of red paeony root, 10g of radix curcumae, 20g of fried rice sprout, 20g of fried malt, 15g of cynanchum glaucescens, 15g of bunge pricklyash seed, 3g of changium smyrnioides, 8g of rice lily, 8g of bamboo shavings, 3g of red yeast rice, 5g of pollen typhae, 2g of water chestnut, 1g of sedum aizoon, 1g of negundo chastetree, 2g of common bluegrass, 10g of adenophora tetraphylla, 10g of loquat leaf, 10g of fritillaria pallidiflora, 5g of walnut, 30g of cordyceps sinensis, 8g of golden broccoli, 1g of trichosanthes kirilowii maxim, 10g of orange peel.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) mixing and crushing rhizoma alismatis, thunberg fritillary bulb, peach kernel, changium smyrnioides, lilium brownii, adenophora tetraphylla, walnut, cordyceps sinensis, trichosanthes kirilowii maxim, rhizoma anemarrhenae and Chinese date, wherein the crushing process is specifically that the raw materials are firstly placed in a freeze dryer, frozen for 4 hours at the temperature of minus 55 ℃, then taken out to be naturally melted for 50 minutes, and then placed in the freeze dryer again to be frozen for 4 hours at the temperature of minus 55 ℃, then taken out to be naturally melted for breaking the cell wall of the raw materials, and then the raw materials are ground for 50-55 minutes in a planetary ball mill at 240r/min, wherein the medium filling rate of the planetary ball mill is 27%, the filling rate of the crushed raw materials is 19%, and the crushed raw materials are sieved by a 60-mesh;
(2) extracting Saviae Miltiorrhizae radix, radix Paeoniae Rubra, radix Curcumae, fructus oryzae Preparata, fructus Hordei Germinatus Preparata, rhizoma Cynanchi Stauntonii, semen Zanthoxyli, caulis Bambusae in Taenia, Monascus purpureus went, pollen Typhae, corm Eleocharitis, radix Desmodii Triquetri, fructus Viticis negundo, herba Eupatorii, folium Eriobotryae, Bulbus Fritillariae Pallidii, radix Lysimachiae Fortunei, pericarpium Citri Junoris, herba Lycopi, and Ulva with 9-12 times of deionized water for 4-6 times, each for 1.5-2.5 hr, filtering, concentrating the filtrate, drying, pulverizing the solid obtained after drying, and making into water extract.
(3) Mixing the fine powder and the water extract, mixing with pharmaceutic adjuvant, and preparing into tablets of 0.4 g/tablet according to a conventional method, wherein the eating method and the eating amount of the tablets are as follows: the composition is administered three times a day, 10-20 tablets each time, for 2 months.
Example 3: a traditional Chinese medicine composition for treating hepatic fibrosis is prepared from the following raw material medicines in parts by weight: 30g of rhizoma alismatis, 15g of thunberg fritillary bulb, 10g of peach kernel, 10g of salvia miltiorrhiza, 10g of red paeony root, 10g of radix curcumae, 15g of fried rice sprout, 15g of fried malt, 10g of cynanchum glaucescens, 20g of zanthoxylum bungeanum maxim, 3g of changium smyrnioides, 6g of rice lily, 10g of bamboo shavings, 2g of red yeast rice, 2g of cattail pollen, 0.8g of water chestnut, 0.5g of sedum aizoon, 0.5g of negundo chastetree, 2g of bluegrass, 10g of adenophora tetraphylla, 10g of loquat leaf, 8g of fritillary bulb, 6g of walnut, 15g of cordyceps sinensis, 5g of golden broccoli, 3g of trichosanthes kirilowii maxim, 12g of orange peel, 3.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) pulverizing Alismatis rhizoma, Bulbus Fritillariae Thunbergii, semen Persicae, radix Changii, Bulbus Lilii, radix Adenophorae, Juglandis, Cordyceps, fructus Trichosanthis, rhizoma anemarrhenae and fructus Jujubae, wherein the pulverizing process comprises placing the raw materials in a freeze-drying machine, freezing at-55 deg.C for 4 hr, taking out, naturally thawing for 50min, placing in a freeze-drying machine, freezing at-55 deg.C for 4 hr, taking out, naturally thawing, breaking cell wall of the raw materials, grinding at 240r/min for 50-55min in a planetary ball mill with medium filling rate of 27% and pulverized raw materials filling rate of 19%, pulverizing, and sieving with 50 mesh sieve to obtain fine powder;
(2) extracting Saviae Miltiorrhizae radix, radix Paeoniae Rubra, radix Curcumae, fructus oryzae Preparata, fructus Hordei Germinatus Preparata, rhizoma Cynanchi Stauntonii, semen Zanthoxyli, caulis Bambusae in Taenia, Monascus purpureus went, pollen Typhae, corm Eleocharitis, radix Desmodii Styracifolii, fructus Viticis negundo, herba Eupatorii, folium Eriobotryae, Bulbus Fritillariae Pallidii, radix Lysimachiae Fortunellae, pericarpium Citri Junoris, herba Lycopi, and Ulva with 9-12 times of deionized water for 4-6 times, each for 1.5-2.5 hr, filtering, concentrating the filtrate, drying, pulverizing the solid obtained after drying to obtain water extract;
(3) mixing the fine powder and the water extract, mixing with pharmaceutic adjuvants, and preparing into a 10 g/bag of bagged preparation according to a conventional method: it is administered once a day, one bag each time, and by decocting with water for half an hour for 2 months.
Example 4: on the basis of the example 1, the example 2 and the example 3, the medical record of which 3 times from 5 months to 6 months in 2019 come to the primary diagnosis in the hospital is treated; the 3 patients all have costalgia symptoms, the symptoms are mild and severe, the accompanying feelings are uncomfortable, abdominal distension and abdominal tolerance are wrong, the tongue pulse is examined to be red, the tongue fur is greasy, the pulse is wiry and western, physical examination type-B ultrasonic is adopted to show hepatic fibrosis, and the western medicine liver protection tablets, the compound turtle shell liver softening tablets and the like are taken before to have poor curative effects. After the medicine is continuously taken for 2 months, costalgia disappears, all symptoms are improved, B-mode ultrasonography is performed again, and hepatic fibrosis is obviously improved.
Example 5: animal testing
1. Experimental Material
1.1 preparation of the pharmaceutical composition
In this example, the best effective herbal composition provided in example 3 was selected as the dose group for testing.
Distilled water was selected as a normal control for comparison in this example.
1.2 animals
120-130g of clean male mice, provided by Experimental animals center of medical academy of sciences, Zhejiang province, with animal license number SCXK Zhe-20180033.
1.3 drugs and reagents
Carbon tetrachloride (CCL)4180503, olive oil, physiological saline, serum, etc. provided by Nanjing's Biochemical Limited.
2. Experimental methods
2.1 hepatic fibrosis model preparation of mice
Randomly dividing 30 mice into 2 groups, randomly dividing normal control group mice into 5 mice, breeding 25 mice in a molding group, breeding 5 mice per cage, molding by the molding group, and giving 35% CCL4Olive oil solution 1 ml/kg-1Preparing a hepatic fibrosis model by subcutaneous injection, and performing continuous 4 weeks for 3 times per week; the normal group was given 1 ml/kg of 0.9% physiological saline-1Injecting subcutaneously for 3 times per week for 4 weeks; during the period of standard feed feeding, the weight, diet, spirit and gross bin changes of the mice are closely observed during the molding experiment.
2.2 Experimental groups and administrations
20 mice of the model building group are taken as an administration group and are randomly divided into 4 groups, each group comprises 5 mice, the groups are divided by a high dose group, a medium dose group, a low dose group and a control group (distilled water), the remaining 5 mice of the model building group are taken as a model building control group, the model building control group and a normal control group are perfused with 0.9 percent physiological saline with the same volume for 1 time/day, and the administration is continuously carried out for 8 weeks.
2.3 detection of various indexes
At 24h after the end of 8 weeks, mice in each group were sacrificed and blood samples were centrifuged, (1000 g,10 min) to separate serum for determination of ALT, AST, Tbil indices, and liver tissue was divided into two portions, one portion for HE staining, Masson staining, TGF-. beta.staining1And the other part is used for measuring MDA, Hyp and SOD after drying the tissue homogenate.
2.4 statistical analysis
Liver function serology ALT, AST, Tbil index, liver tissue TGF-beta1MDA and T-SODHyp indexes, all experimental data are expressed in x +/-s, and statistical analysis is carried out by using SPSS 22.0. And analyzing the significance of the difference of each parameter by using variance, wherein P is less than 0.05 to indicate that the difference has statistical significance.
3. Results of the experiment
3.1 mouse Condition
In the preparation stage of molding, the mice in the normal control group are white and glossy, have good buddhist state, are agile in activity, and are in normal state with respect to intake of water and stool. The skin hair disease of the model group is yellow, greasy, coarse and young, listlessness, slow action, abdominal distension and abdominal distension, ascites can be seen in dissection, and little water is drunk; in the administration experiment stage, the mice in the normal control group have no abnormality, and the mice in the high, medium and low dose groups in the administration group are generally improved to different degrees compared with the control group and the model control group.
3.2 serological index results of liver function
The results of liver function serological indexes are shown in table 1, and compared with the control group, each dosage group using the traditional Chinese medicine composition of the embodiment 3 of the invention has good treatment effect on the liver function of the hepatic fibrosis of mice (P < 0.05).
TABLE 1 Effect of the Chinese medicinal composition of example 3 on mouse liver fibrosis serum index (+ -s, n = 10)
Group of | ALT(U/L) | AST(U/L) | Tbil(mol/L) |
Normal control group | 57.54±5.75 | 120.78±9.45 | 1.52±0.24 |
Modeling control group | 245.11±7.821 | 211.84±8.151 | 2.12±0.151 |
Control group | 242.01±7.621 | 221.84±7.151 | 2.11±0.151 |
High dose group | 176.51±17.461 | 140.45±7.452 | 1.64±0.1523 |
Middle dose group | 204.15±6.4823 | 147.54±7.1023 | 1.78±0.212 |
Low dose group | 224.95±4.152 | 178.47±6.142 | 1.87±0.182 |
1. P <0.05 compared to normal control group; 2. p <0.05 compared to control;
3.3 liver tissue SOD, MDA and Hyp
The results of the liver tissue SOD, MDA and Hyp experiments are shown in Table 2, and compared with the control group, the traditional Chinese medicine composition of the embodiment 3 has good treatment effect on the liver function of the hepatic fibrosis of mice by adopting each dose group (P is less than 0.05).
Table 2: the effect of the Chinese medicinal composition of example 3 on the liver fibrosis index of mice (± s, n = 10)
Group of | SOD(U/mgprot) | MDA(U/mgprot) | Hyp(g/g) |
Normal control group | 261.22±9.84 | 4.35±0.02 | 262.45±18.44 |
Modeling control group | 164.55±6.821 | 8.84±0.031 | 432.15±15.151 |
Control group | 161.55±5.321 | 8.56±0.031 | 431.85±13.151 |
High dose group | 244±7.4623 | 6.45±0.0423 | 315±15.1523 |
Middle dose group | 220.15±9.1523 | 6.97±0.0223 | 345±18.2123 |
Low dose group | 201.95±8.5123 | 7.15±0.012 | 380±14.182 |
1. P <0.05 compared to normal control group; 2. p <0.05 compared to control;
3.4 hepatic tissue TGF-. beta.1
Hepatic tissue TGF-beta1The experimental results are shown in table 3, and compared with the control group, each dose group using the Chinese medicinal composition of example 3 of the present invention has a good therapeutic effect on liver function of hepatic fibrosis in mice (P)< 0. 05)。
Table 3: example 3 Effect of the Chinese medicinal composition on hepatic tissue TGF- β 1 (± s, n = 10)
Group of | Hepatic tissue TGF-beta1(pg·g-1) |
Normal control group | 1484.48±54.94 |
Modeling control group | 4588±67.451 |
Control group | 4556±69.151 |
High dose group | 2548±68.76234 |
Middle dose group | 3248±75.98234 |
Low dose group | 3845±67.2923 |
1. P <0.05 compared to normal control group; 2. p <0.05 compared to control;
3.5 histopathological results of liver
3.5.1 HE staining
The HE staining results show that the liver cells of the normal control mice are normal in morphology, and inflammation and necrosis are not visible. The liver cells of the mice of the model-making control group have large-area inflammation candles and necrosis, the area is large, and the obvious tandem area of the courseware under the light lens is thickened. In the administration group, inflammatory foci and necrotic foci with medium or small area can be seen in liver tissue, a large number of necrotic foci are small area, spotty necrosis is more, thickening phenomenon can be seen in the area of the sink, but the treatment effect is improved to a different extent compared with the control group. Pathological results in the high dose group showed less marked enlargement of the area of the sink, except for small areas of punctate foci of inflammation and necrosis due to liver fibrosis.
3.5.2 massson staining
The masson staining result shows that the shape of the liver cells of the mice in the normal control group is complete, and the pathological condition of hepatic fibrosis does not exist. The pathological result of the liver tissue of the mice in the model-making control group shows that the liver fibrosis is serious, the proliferation of collagen fibers is obviously increased, the liver cells are necrotic, the vascular area is thickened, and the fibrosis of the mice is mostly in stages III-IV. The liver tissues of mice in the administration group treated by the traditional Chinese medicine composition have smaller areas of collagen and fibrous tissues and lower occurrence number. The pathology of the liver fibrosis disease under the microscope is obviously reduced compared with that of mice of a control group of a model group in a high-dose group, the liver fibrosis grade is basically stage II, and the liver fibrosis disease is effectively treated after administration intervention.
Claims (7)
1. A traditional Chinese medicine composition for treating hepatic fibrosis is characterized in that: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-100 parts of rhizoma alismatis, 5-30 parts of thunberg fritillary bulb, 5-30 parts of peach kernel, 5-20 parts of salvia miltiorrhiza, 5-30 parts of red paeony root, 5-30 parts of radix curcumae, 10-40 parts of fried rice sprout, 10-40 parts of fried malt, 5-20 parts of cynanchum glaucescens, 5-30 parts of pepper, 1-5 parts of changium smyrnioides, 1-10 parts of rice lily, 5-15 parts of bamboo shavings, 1-5 parts of red yeast rice, 1-10 parts of pollen typhae, 0.5-2 parts of water chestnut, 0.1-2 parts of sedum pratense root, 0.1-2 parts of negundo chastetree fruit, 1-3 parts of common bluegrass, 5-40 parts of adenophora tetraphylla, 2-30 parts of loquat leaf, 1-20 parts of fritillary bulb, 1-10 parts of walnut, 1-30 parts of cordyceps sinensis, 1-10 parts of golden cypress, 1-5 parts of trichosanthes kirilowii maxim, 10-100 parts of ulva, 5-50 parts of rhizoma anemarrhenae and 5-30 parts of Chinese date.
2. The Chinese medicinal composition for treating hepatic fibrosis according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-50 parts of rhizoma alismatis, 10-20 parts of thunberg fritillary bulb, 5-20 parts of peach kernel, 5-15 parts of salvia miltiorrhiza, 5-15 parts of red paeony root, 5-15 parts of radix curcumae, 12-18 parts of fried rice sprout, 12-17 parts of fried malt, 5-15 parts of cynanchum glaucescens, 10-25 parts of pepper, 2-4 parts of changium smyrnioides, 2-8 parts of rice lily, 8-13 parts of bamboo shavings, 1-3 parts of red yeast rice, 1-5 parts of cattail pollen, 0.5-1 part of water chestnut, 0.1-1 part of sedum pratense, 0.1-1 part of negundo chastetree fruit, 1.5-2.5 parts of common bluebeard herb, 5-20 parts of adenophora tetraphylla, 5-15 parts of loquat leaf, 1-15 parts of illipe, 5-8 parts of walnut, 10-20 parts of cordyceps sinensis, 3-8 parts of golden broccoli, 2.5-3.5 parts of trichosanthes kirilowii maxim, 10-50 parts of ulva, 5-20 parts of rhizoma anemarrhenae and 10-20 parts of Chinese date.
3. The Chinese medicinal composition for treating hepatic fibrosis according to claim 2, wherein: the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 30 parts of rhizoma alismatis, 15 parts of thunberg fritillary bulb, 10 parts of peach kernel, 10 parts of salvia miltiorrhiza, 10 parts of red paeony root, 10 parts of radix curcumae, 15 parts of fried rice sprout, 15 parts of fried malt, 10 parts of cynanchum glaucescens, 20 parts of zanthoxylum bungeanum maxim, 3 parts of changium smyrnioides, 6 parts of rice lily, 10 parts of bamboo shavings, 2 parts of red yeast rice, 2 parts of pollen typhae, 0.8 part of water chestnut, 0.5 part of sedum aizoon, 0.5 part of negundo chastetree, 2 parts of bluegrass, 10 parts of adenophora tetraphylla, 10 parts of loquat leaf, 8 parts of fritillary bulb, 6 parts of walnut, 15 parts of cordyceps sinensis, 5 parts of golden broccoli, 3 parts of trichosanthes kirilowii maxim, 12 parts of orange peel.
4. The method for preparing a Chinese medicinal composition for treating liver fibrosis according to any one of claims 1-3, wherein the composition comprises: the method comprises the following steps:
(1) pulverizing Alismatis rhizoma, Bulbus Fritillariae Thunbergii, semen Persicae, radix Changii, Bulbus Lilii, radix Adenophorae, Juglandis, Cordyceps, fructus Trichosanthis, rhizoma anemarrhenae and fructus Jujubae, and sieving with 40-60 mesh sieve to obtain fine powder;
(2) extracting Saviae Miltiorrhizae radix, radix Paeoniae Rubra, radix Curcumae, fructus oryzae Preparata, fructus Hordei Germinatus Preparata, rhizoma Cynanchi Stauntonii, semen Zanthoxyli, caulis Bambusae in Taenia, Monascus purpureus went, pollen Typhae, corm Eleocharitis, radix Desmodii Styracifolii, fructus Viticis negundo, herba Eupatorii, folium Eriobotryae, Bulbus Fritillariae Pallidii, radix Lysimachiae Fortunellae, pericarpium Citri Junoris, herba Lycopi, and Ulva with 9-12 times of deionized water for 4-6 times, each for 1.5-2.5 hr, filtering, concentrating the filtrate, drying, pulverizing the solid obtained after drying to obtain water extract;
(3) mixing the fine powder and water extract, mixing with medicinal adjuvants, and making into oral preparation by conventional method.
5. Use of the Chinese medicinal composition according to any one of claims 1 to 4 in the preparation of a medicament for treating liver fibrosis.
6. The Chinese medicinal composition for treating liver fibrosis according to any one of claims 1-4, wherein: the Chinese medicinal composition can be made into hard capsule, soft capsule, tablet, granule, powder, pill, tea bag or water decoction.
7. The method for preparing a Chinese medicinal preparation for treating hepatic fibrosis according to claim 4, wherein the preparation comprises the following steps: the crushing process specifically comprises the steps of putting the raw materials in the step (1) into a freeze dryer, freezing for 4 hours at-55 ℃, taking out the raw materials to naturally melt for 50 minutes, putting the raw materials into the freeze dryer again, freezing for 4 hours at-55 ℃, taking out the raw materials to naturally melt for breaking the cell walls of the raw materials, putting the raw materials into a planetary ball mill, and grinding for 50-55 minutes at 240r/min, wherein the medium filling rate of the planetary ball mill is 27%, and the filling rate of the crushed raw materials is 19%.
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