CN114404517A - Composition for gout and reducing uric acid and application and preparation method thereof - Google Patents

Composition for gout and reducing uric acid and application and preparation method thereof Download PDF

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Publication number
CN114404517A
CN114404517A CN202210116349.6A CN202210116349A CN114404517A CN 114404517 A CN114404517 A CN 114404517A CN 202210116349 A CN202210116349 A CN 202210116349A CN 114404517 A CN114404517 A CN 114404517A
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parts
citrate
composition
raw materials
gout
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孔庆博
张建华
王阳
王一雷
王丹
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Guodingshanhe Hainan Pharmaceutical Group Co ltd
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Guodingshanhe Hainan Pharmaceutical Group Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents

Abstract

The invention discloses a composition for gout and reducing uric acid, and application and a preparation method thereof, wherein the composition comprises the following components: ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum, cordyceps militaris, honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate. The invention also provides the application of the composition in preparing oral medicaments. The invention also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials, cleaning and drying the washable medicinal materials in the raw materials, grinding and crushing the medicinal materials, adding water for decoction, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding the rest raw materials, uniformly mixing, and finally processing into an oral medicament. The composition provided by the invention can be used in medicine-food homologous medicaments for various types of gout and related diseases, and can reduce uric acid without long-term adoption of diet therapy, so that patients can recover.

Description

Composition for gout and reducing uric acid and application and preparation method thereof
Technical Field
The invention relates to a pharmaceutical composition, application and a preparation method thereof, in particular to a composition for treating gout and reducing uric acid, and application and a preparation method thereof.
Background
Gout (Gout) is a common and complex type of arthritis that can develop in all age groups, with men having a higher incidence than women. Patients with gout often have sudden joint pain at night, the joint is in urgent attack, severe pain, edema, red swelling and inflammation appear at the joint, and the pain is slowly relieved until the pain disappears for days or weeks. Gout attack is related to the concentration of uric acid in a body, and gout can form urate deposition in joint cavities and the like, activate the immune system of the body, and further cause acute joint pain.
There are two main methods of treating gout, namely a medication method and a diet therapy method. The medicines for treating gout mainly comprise non-steroidal anti-inflammatory drugs and glucocorticoids, but the current methods for treating gout by medicines are less in use; drinking with low food is a more common treatment. Dietotherapy mainly aims at reducing consumption of high-purine food, high-fat food and the like. The more purine content in human body, the more uric acid is produced by metabolism, and the alcohol stimulates liver to produce uric acid, which increases the incidence rate of gout and the harm of gout to human body.
However, products made of natural Chinese herbal medicines and other components are not adopted in domestic and world markets at present, and the processed and produced health-care and treatment medicament with homology of medicine and food for gout and other diseases can reduce uric acid without adopting diet therapy for a long time, so that patients can recover.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition, and an application and a preparation method thereof, the pharmaceutical composition can be used for solving the existing problems, is used for gout and other diseases, and can reduce uric acid by using medicinal and edible raw materials and medicinal materials without adopting diet therapy for a long time, so that patients can recover.
In order to achieve the above objects, the present invention provides a composition for gout and uric acid reduction, wherein the composition comprises the following raw materials: ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum, cordyceps militaris, honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate.
The composition for treating gout and reducing uric acid is characterized in that polygonatum sibiricum is adopted as raw materials of the composition, and lycium ruthenicum is adopted as medlar.
The composition for treating gout and reducing uric acid comprises the following raw materials in parts by weight: 20-30 parts of ginseng, 20-30 parts of orange peel, 15-25 parts of resistant dextrin, 30-40 parts of honeysuckle extract, 20-30 parts of green tea extract, 30-40 parts of Jiuhua sealwort, 25-35 parts of sodium citrate, 30-40 parts of liquorice, 25-35 parts of potassium citrate, 45-55 parts of black wolfberry, 25-35 parts of ferric citrate, 25-35 parts of chrysanthemum, 25-35 parts of manganese citrate and 40-50 parts of cordyceps militaris.
The composition for treating gout and reducing uric acid comprises the following raw materials in parts by weight: 25g of ginseng, 25g of orange peel, 20g of resistant dextrin, 35g of honeysuckle extract, 25g of green tea extract, 35g of Jiuhua sealwort, 30g of sodium citrate, 35g of liquorice, 30g of potassium citrate, 50g of black wolfberry, 30g of ferric citrate, 30g of chrysanthemum, 30g of manganese citrate and 45g of cordyceps militaris.
The invention also provides application of the composition for treating gout and reducing uric acid, wherein the composition is used for preparing an oral medicament.
The invention also provides a preparation method of the medicament, wherein the method comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable medicinal materials in the raw materials, grinding and crushing the medicinal materials, adding water for decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding the rest raw materials, uniformly mixing, and finally processing into an oral medicament.
The preparation method of the medicament comprises the steps of crushing and pulverizing ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum and cordyceps militaris, adding water for decoction, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate, adding other auxiliary materials according to requirements, mixing uniformly, grinding and sieving to obtain medicinal powder.
The preparation method of the medicament comprises the following steps of taking the medicinal powder as granules, and taking the granules with warm boiled water; or encapsulating to obtain capsule.
The composition for gout and reducing uric acid provided by the invention and the application and the preparation method thereof have the following advantages:
the invention utilizes the technologies of biological pharmacy and the like and high purification and extraction means, and the cooperation and verification of the Chinese medical science college of the Chinese academy of sciences break through the prior art of treating and recovering gout and related diseases, the obtained medicament can effectively aim at the diseases of gout and the like, takes the theory of the traditional Chinese medicine as guidance, preferably selects raw materials and medicinal materials with homology of medicine and food as basic collocation, combines the modern advanced biochemical pharmacy technology, improves the metabolism and the excretion capability of a body from the angles of calming the liver, warming the kidney and strengthening the spleen of the traditional Chinese medicine, further internalises the generation process of hyperuricemia, purifies blood, improves the capability of dissolving and crystallizing blood, and can effectively treat the gout and hyperuricemia after being taken.
Detailed Description
The following further describes embodiments of the present invention.
The invention provides a composition for gout and reducing uric acid, which comprises the following raw materials: the raw materials of the composition comprise: ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum, cordyceps militaris, honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate.
Wherein the Ginseng radix is a perennial herb, and contains multiple saponin and polysaccharide components. The succulent root of ginseng is a well-known tonic, is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and also has expectorant, stomach invigorating, diuretic and exciting effects. Sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, tranquilizing, and improving intelligence. Mainly treats asthenia, desire for desertion, cold limbs and a little pulse, spleen deficiency, poor appetite, lung deficiency, cough and asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of deficiency caused by chronic diseases, palpitation, insomnia, impotence and cold womb; heart failure, cardiogenic shock. Can be used for treating short breath, dyspnea, palpitation, amnesia, thirst, hyperhidrosis, anorexia, asthenia, acute and chronic diseases, and shock and collapse caused by blood loss. Tonify primordial qi, relieve depletion and promote fluid production, induce tranquilization. It is indicated for deficiency due to overstrain, poor appetite, lassitude, regurgitation, diarrhea, cough, dyspnea, spontaneous sweating, palpitation, amnesia, vertigo, headache, impotence, frequent micturition, diabetes, metrorrhagia, metrostaxis, chronic infantile convulsion, and deficiency of both qi and blood.
Pericarpium Citri Tangerinae. The pericarpium Citri Tangerinae is dried mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar; picking mature fruit, peeling peel, and drying in the sun or at low temperature. Bitter and pungent taste, warm in nature; entering lung and spleen meridians; has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm; it can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm; it is combined with cang Zhu and Hou Po to treat gastric and abdominal distention and pain, nausea, vomiting and diarrhea due to cold-dampness in middle energizer and qi stagnation in spleen and stomach.
The rhizoma Polygonati is Jiuhua rhizoma Polygonati. Jiuhua Polygonatum sibiricum Red is a special product in Qingyang county of Anhui province, and is prepared by planting and digging Polygonatum sibiricum Red in the peripheral area of Jiuhua mountain. Jiuhua rhizoma polygonati, also called Dizang rhizoma polygonati, has the functions of food and medicine, has the functions of tonifying middle-jiao energy, strengthening muscles and bones and reducing high blood pressure, and can effectively enhance the immunologic function of a human body. The main functional components of the health-care food are polygonatum polysaccharide, amino acid, trace elements, anthraquinone and the like, and the health-care food is also rich in various trace elements necessary for human bodies, and various components such as protein, starch, amino acid, rehmannia root and the like, and has the effects of tonifying kidney, reducing blood, preventing arteriosclerosis, promoting insulin activity and the like.
The Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat or Glycyrrhiza glabra L of Leguminosae. Collected in spring and autumn, removed fibrous root, and dried in the sun. Sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the medicines. It is indicated for spleen and stomach deficiency, lassitude and hypodynamia, palpitation and shortness of breath, cough with profuse sputum, spasm and pain of abdomen and limbs, carbuncle and sore, and to relieve toxicity and strong action of drugs.
The fructus Lycii is fructus Lycii, i.e. the fruit of Lycium ruthenicum Murr. Lycium ruthenicum Murr of Solanaceae is Bush with spiny thorn, and has effects of blooming and fruiting in 5-10 months, purple black berry, spherical shape, kidney shape seed, and brown color. The lycium ruthenicum murr is sweet in taste and neutral in nature, and is rich in various nutritional ingredients such as protein, lycium ruthenicum polysaccharide, amino acid, vitamins, mineral substances, trace elements and the like. Besides the similar efficacy of the lycium ruthenicum murr, the lycium ruthenicum murr also contains rich lycium ruthenicum pigment (natural procyanidine, OPC for short), the OPC content of the lycium ruthenicum murr exceeds that of blueberry, and the lycium ruthenicum murr is a natural wild plant with the highest OPC content discovered up to now. Procyanidins OPC are the most effective natural water-soluble radical scavengers.
The flos Chrysanthemi is dry capitula of Chrysanthemum morifolium Ramat of Compositae. Pungent, sweet, bitter and slightly cold in nature; it enters lung and liver meridians. Has the effects of dispelling wind and heat, suppressing liver yang, removing liver heat, improving eyesight, and clearing away heat and toxic materials. It can be used for treating wind-heat type common cold, early stage of epidemic febrile disease, vertigo due to liver-yang, excessive liver-wind, conjunctival congestion, blurred vision, sore, carbuncle, and toxic swelling.
Cordyceps militaris is fungus of Cordyceps of Clavipitaceae, also called Cordyceps militaris, and abbreviated as Cordyceps militaris. Cordyceps militaris is a complex composed of a stroma (i.e., grass part) and a sclerotium (i.e., cadaver part of the insect). Cordyceps militaris is a fungus used as both food and medicine, the protein content of the fungus is as high as 40.7%, and the contained amino acids necessary for human body are complete in variety, sufficient in quantity and appropriate in proportion. The artificially cultivated cordyceps militaris also contains abundant vitamins, minerals and the like, and has good edible value. The cordyceps militaris stroma can be used as a medicine, has mild nature and sweet taste, benefits lung and kidney, stops bleeding and reduces phlegm, and can be generally used for treating pulmonary tuberculosis, weakness of old people, anemia and weakness and the like. Cordyceps militaris contains abundant cordycepic acid, cordycepin, ergosterol, etc., and has effects of expanding trachea, tranquilizing, resisting various bacteria, and lowering blood pressure.
The honeysuckle extract is an extract extracted from a natural plant honeysuckle, mainly contains chlorogenic acid, is brown powder in color, and can be used as a raw material of medicines, health-care products and cosmetics. The flos Lonicerae is dried bud or flower with initial blossom of Lonicera Japonica Thunb, Lonicera hypoglauca Miq, Lonicera confusa or Lonicera dasystyla of Caprifoliaceae. Sweet in nature and taste and cold in nature; it enters lung, heart and stomach meridians. Has the effects of clearing away heat and toxic materials, and dispelling pathogenic wind and heat. It is mainly used for treating carbuncle, furuncle, wind-heat type affection, early stage of epidemic febrile disease, and dysentery with blood due to toxic heat. The pharmacological actions include resisting pathogenic microorganism, resisting virus, resisting inflammation, promoting phagocytic function of inflammatory cell, reducing blood lipid, exciting central nerve, resisting fertility, and treating sarcoma S180 and Ehrlich ascites carcinoma with obvious cytotoxic effect.
The green tea extract is an active ingredient extracted from green tea leaves, and mainly comprises tea polyphenol (catechin), caffeine, aromatic oil, water, minerals, pigments, carbohydrates, proteins, amino acids, vitamins, etc. The green tea is prepared by fermenting, retains natural substances of fresh leaves, and contains more nutrients such as tea polyphenols, catechin, chlorophyll, caffeine, amino acids, vitamins, etc. The natural nutrient components in the green tea have special effects of anti-aging, cancer prevention, cancer resistance, sterilization, inflammation diminishing and the like, and are beyond the reach of other tea. Modern science has proved that the green tea contains biochemical components closely related to human health, and has pharmacological actions of refreshing, clearing away heat, relieving summer-heat, promoting digestion, reducing phlegm, removing greasiness, reducing weight, clearing away heart-fire, relieving restlessness, removing toxic substances, relieving hangover, promoting fluid production, quenching thirst, lowering fire, improving eyesight, relieving dysentery, eliminating dampness, etc., and has certain pharmacological effects on modern diseases, such as radiation disease, cardiovascular and cerebrovascular diseases, cancer, etc. The green tea is bitter and sweet in nature and cool. The main functional indications are as follows: clearing head and eyes, removing polydipsia, reducing phlegm, promoting digestion, promoting urination and removing toxicity. It is indicated for headache, blurred vision, insomnia, restlessness, thirst, food stagnation, phlegm stagnation, malaria and dysentery.
The resistant dextrin is processed by starch, is a low-calorie glucan which is prepared by extracting and refining indigestible components of baked dextrin by using industrial technology, and belongs to low-molecular water-soluble dietary fiber. The resistant dextrin has low calorie, heat resistance, acid resistance and freezing resistance, can be used as a low-calorie soluble food raw material, and has wide development prospect in the food industry.
Preferably, the composition comprises the following raw materials in parts by weight: 20-30 parts of ginseng, 20-30 parts of orange peel, 15-25 parts of resistant dextrin, 30-40 parts of honeysuckle extract, 20-30 parts of green tea extract, 30-40 parts of Jiuhua sealwort, 25-35 parts of sodium citrate, 30-40 parts of liquorice, 25-35 parts of potassium citrate, 45-55 parts of black wolfberry, 25-35 parts of ferric citrate, 25-35 parts of chrysanthemum, 25-35 parts of manganese citrate and 40-50 parts of cordyceps militaris.
More preferably, the raw materials of the composition comprise by weight: 25g of ginseng, 25g of orange peel, 20g of resistant dextrin, 35g of honeysuckle extract, 25g of green tea extract, 35g of Jiuhua sealwort, 30g of sodium citrate, 35g of liquorice, 30g of potassium citrate, 50g of black wolfberry, 30g of ferric citrate, 30g of chrysanthemum, 30g of manganese citrate and 45g of cordyceps militaris.
The raw materials are wild Chinese herbal medicines, and perennial Chinese herbal medicines are five years or more. The material is obtained from wild rare animals and plants, and can be artificially cultured and planted under the condition that conditions are not allowed, or other substitutes with equal and similar effects.
The invention also provides application of the composition for treating gout and reducing uric acid, and the composition is used for preparing an oral medicament.
The invention also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable medicinal materials in the raw materials, grinding and crushing the medicinal materials, adding water for decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding the rest raw materials, uniformly mixing, and finally processing into an oral medicament.
Preferably, in the method, ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum and cordyceps militaris are crushed and pulverized, water is added for decoction, liquid medicine is obtained after filtration, ointment is obtained after further concentration, honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate are added after drying, other auxiliary materials can be added according to the needs, the mixture is uniformly mixed, and finally the mixture is ground and sieved to obtain medicinal powder.
The obtained medicinal powder is taken as granule with warm boiled water; or encapsulating to obtain capsule, and administering with warm water.
In the method, preferably, the ointment obtained by concentration is added with auxiliary materials to be prepared into pills, or is prepared into tablets by tabletting.
The auxiliary materials adopted in the method are common auxiliary materials used in pharmaceutical technology and known by the technical personnel in the field.
Other specific conditions and equipment, etc. employed in the process are known to those skilled in the art.
The composition for gout and uric acid reduction provided by the invention, and the use and preparation method thereof are further described below with reference to examples.
Example 1
A composition for gout and reducing uric acid, which comprises the following raw materials in percentage by weight:
25g of ginseng, 25g of orange peel, 20g of resistant dextrin, 35g of honeysuckle extract, 25g of green tea extract, 35g of Jiuhua sealwort, 30g of sodium citrate, 35g of liquorice, 30g of potassium citrate, 50g of black wolfberry, 30g of ferric citrate, 30g of chrysanthemum, 30g of manganese citrate and 45g of cordyceps militaris.
The embodiment also provides application of the composition for treating gout and reducing uric acid, and the composition is used for preparing oral medicaments.
The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials according to a certain proportion, cleaning and drying the washable medicinal materials in the raw materials, crushing and pulverizing ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum and cordyceps militaris, adding water for decoction, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate, adding other auxiliary materials according to requirements, uniformly mixing, and finally grinding and sieving to obtain medicinal powder.
The obtained medicinal powder can be used as granule to be taken with warm boiled water.
Example 2
A composition for gout and reducing uric acid, which comprises the following raw materials in percentage by weight:
20g of ginseng, 20g of orange peel, 15g of resistant dextrin, 30g of honeysuckle extract, 20g of green tea extract, 30g of Jiuhua sealwort, 25g of sodium citrate, 30g of liquorice, 25g of potassium citrate, 45g of black wolfberry, 25g of ferric citrate, 25g of chrysanthemum, 25g of manganese citrate and 40g of cordyceps militaris.
The embodiment also provides application of the composition for treating gout and reducing uric acid, and the composition is used for preparing oral medicaments.
The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials according to a certain proportion, cleaning and drying the washable medicinal materials in the raw materials, crushing and pulverizing ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum and cordyceps militaris, adding water for decoction, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate, adding other auxiliary materials according to requirements, uniformly mixing, and finally grinding and sieving to obtain medicinal powder.
The obtained medicinal powder is filled into capsule, and made into capsule, which is taken with warm boiled water.
Example 3
A composition for gout and reducing uric acid, which comprises the following raw materials in percentage by weight:
30g of ginseng, 30g of orange peel, 25g of resistant dextrin, 40g of honeysuckle extract, 30g of green tea extract, 40g of Jiuhua rhizoma polygonati, 35g of sodium citrate, 40g of liquorice, 35g of potassium citrate, 55g of black wolfberry, 35g of ferric citrate, 35g of chrysanthemum, 35g of manganese citrate and 50g of cordyceps militaris.
The embodiment also provides application of the composition for treating gout and reducing uric acid, and the composition is used for preparing oral medicaments.
The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials according to a certain proportion, cleaning and drying the washable medicinal materials in the raw materials, crushing and pulverizing ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum and cordyceps militaris, adding water for decoction, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate, adding other auxiliary materials according to requirements, uniformly mixing, and finally grinding and sieving to obtain medicinal powder.
The obtained medicinal powder is taken as granule with warm boiled water; or encapsulating to obtain capsule, and administering with warm water.
The raw materials adopted in the embodiments of the invention respectively accord with the corresponding national standards and regulations.
Clinical trials of the medicament prepared by the embodiments of the invention prove that the composition has obvious effect and can be used for preparing a specific medicament for pertinently treating gout and hyperuricemia.
The composition for gout and uric acid reduction and the application and the preparation method thereof provided by the invention are prepared by combining natural Chinese herbal medicines and raw materials with homology of medicine and food, are prepared based on ancient manual processing, are combined with modern similar biological and pharmaceutical technologies, are prepared by purifying, concentrating, mixing and pulverizing, and are new after being promoted, so that the special-effect medicament for reducing the magic volt wind poison which can be orally taken can be finally produced. The medicine is also named as Jiuzhen Zhengfeng powder.
The composition also has the characteristics of reasonable formula, small dosage, obvious effect, small toxic and side effect, quick response, difficult relapse and the like, and has the advantages of simple and easily obtained components, convenient processing, low price, high quality, economy, practicability and the like.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims (8)

1. A composition for gout and reducing uric acid is characterized in that the raw materials of the composition comprise: ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum, cordyceps militaris, honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate.
2. The composition for gout and uric acid reduction as claimed in claim 1, wherein the raw materials of the composition comprise polygonatum sibiricum and lycium ruthenicum.
3. The composition for gout and uric acid reduction according to claim 2, wherein the composition comprises the following raw materials in parts by weight: 20-30 parts of ginseng, 20-30 parts of orange peel, 15-25 parts of resistant dextrin, 30-40 parts of honeysuckle extract, 20-30 parts of green tea extract, 30-40 parts of Jiuhua sealwort, 25-35 parts of sodium citrate, 30-40 parts of liquorice, 25-35 parts of potassium citrate, 45-55 parts of black wolfberry, 25-35 parts of ferric citrate, 25-35 parts of chrysanthemum, 25-35 parts of manganese citrate and 40-50 parts of cordyceps militaris.
4. The composition for gout and uric acid reduction as claimed in claim 3, wherein the raw materials of the composition comprise, by weight: 25g of ginseng, 25g of orange peel, 20g of resistant dextrin, 35g of honeysuckle extract, 25g of green tea extract, 35g of Jiuhua sealwort, 30g of sodium citrate, 35g of liquorice, 30g of potassium citrate, 50g of black wolfberry, 30g of ferric citrate, 30g of chrysanthemum, 30g of manganese citrate and 45g of cordyceps militaris.
5. Use of the composition for gout and uric acid reduction according to any one of claims 1 to 4, wherein the composition is used for preparing a medicament for internal administration.
6. A method of preparing the medicament of claim 5, wherein the method comprises: weighing the raw materials in proportion, cleaning and drying the washable medicinal materials in the raw materials, grinding and crushing the medicinal materials, adding water for decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding the rest raw materials, uniformly mixing, and finally processing into an oral medicament.
7. The method for preparing the medicament as claimed in claim 6, wherein the method comprises the steps of crushing and pulverizing ginseng, orange peel, rhizoma polygonati, liquorice, medlar, chrysanthemum and cordyceps militaris, adding water for decoction, filtering to obtain liquid medicine, further concentrating to obtain ointment, drying, adding honeysuckle extract, green tea extract, resistant dextrin, sodium citrate, potassium citrate, manganese citrate and ferric citrate, adding other auxiliary materials according to requirements, mixing uniformly, grinding and sieving to obtain medicinal powder.
8. The method for preparing the medicament of claim 7, wherein the powder is taken as granules with warm boiled water; or encapsulating to obtain capsule.
CN202210116349.6A 2022-02-07 2022-02-07 Composition for gout and reducing uric acid and application and preparation method thereof Pending CN114404517A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109172770A (en) * 2018-11-13 2019-01-11 张洪搏 Facilitate the herbal composite and preparation method thereof of uric acid adjusting
CN110559389A (en) * 2019-09-23 2019-12-13 阳元贵 traditional Chinese medicine wine for treating hyperuricemia, gout and rheumatism and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109172770A (en) * 2018-11-13 2019-01-11 张洪搏 Facilitate the herbal composite and preparation method thereof of uric acid adjusting
CN110559389A (en) * 2019-09-23 2019-12-13 阳元贵 traditional Chinese medicine wine for treating hyperuricemia, gout and rheumatism and preparation method thereof

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