CN103719552A - Feed for preventing and treating swine erysipelas and preparation method for feed - Google Patents
Feed for preventing and treating swine erysipelas and preparation method for feed Download PDFInfo
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- CN103719552A CN103719552A CN201310744843.8A CN201310744843A CN103719552A CN 103719552 A CN103719552 A CN 103719552A CN 201310744843 A CN201310744843 A CN 201310744843A CN 103719552 A CN103719552 A CN 103719552A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a feed for preventing and treating swine erysipelas and a preparation method for the feed. The feed comprises the following raw materials of barley, wheat, composite enzyme, yam powder, methionine, threonine, vitamin premix and a traditional Chinese medicinal additive. The feed disclosed by the invention has the beneficial effects that the feed contains the traditional Chinese medicinal additive for treating the swine erysipelas, and the main therapeutic principle of the traditional Chinese medicinal additive is to clear away heat and purge pathogenic fire, nourish yin, promote the secretion of saliva or body fluid, regulate qi and blood and regulate spleen and stomach; the traditional Chinese medicinal additive and other feed raw materials are interactive and are matched, so that the feed has an outstanding preventing and treating effect on the swine erysipelas and has the advantages of low side effect, high curing rate, short treating course, less possibility of relapse and the like.
Description
Technical field
The present invention relates to a kind of pig feed, particularly a kind of for preventing and treating feed of brickpox and preparation method thereof.
Background technology
Brickpox is a kind of acute heat sexually transmitted disease that bacillus rhusiopathiae suis causes, its principal character is high heat, acute sepsis, skin rash piece (subacute), chronic libman-Sack endocarditis and cutaneous necrosis and multiple non suppurative arthritis (chronic).Intensive Farm of Pig Raising is more rare at present, but controls completely not yet.This disease is worldwide distribution.Bacillus rhusiopathiae suis is a kind of gram-positive bacteria, has the tendency of obvious formation long filament.This bacterium is straight or micro-curved very thin dialister bacterium, and size is 0.2～0.4 micron × 0.8～2.5 micron.Bacterium in pathological material of disease, singly, in pairs or become clump to arrange, in leucocyte general become clump exist, in outmoded broth culture and in the internal membrane of heart wart-like lump of chronic disease pig, be long filament shape more, sometimes very thin.This bacterium is stronger to the resistance of the natural environments such as salted, fire is smoked, dry, corruption and daylight.
In the liver of pig that dies of illness, spleen 4 ℃ 159 days, virulence is still powerful.The outdoor placement pig liver of dying of illness of 27 days, buried 1.5 meters of sick pig corpse of 231 days, 12.5% salt is processed and is refrigerated in 4 ℃ of pork of 148 days, can be separated to bacillus rhusiopathiae suis.At general disinfectant, as very fast dead in 2% formalin, l% bleaching powder, 1% NaOH or 5% carbonic acid.To hot resistance a little less than, broth culture is in 50 ℃ through 12～20 minutes, 70 ℃ can be killed for 5 minutes.The acid resistance of this bacterium is stronger, and the acidity in pig stomach can not be killed it, therefore can enter enteron aisle through stomach.
the pathological change of brickpox is: at the bottom of (1) acute stomach and the vigorous film generation of pyloric part diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal or hemorrhagic inflammation in various degree; Splenomegaly, is typical sepsis spleen; Kidney extravasated blood, enlargement, have the title of " large purple kidney "; Lymph node hyperemia, enlargement, tangent plane turns up, succulence, lungs extravasated blood, the congested spot of the subacute type of oedema (2) center can be pale asphyxia because of oedema compressing.(3) 1. endocarditis of chronic type: can see the endocarditic pathology bicuspid valve of defect shape and cauliflower-like proliferation appears in aorta petal at heart.2. arthritis: arthroncus, has serosity, fibrinous exudate to accumulate.
The cardinal symptom of brickpox is: short 1 day of incubation period of clinical symptoms, long 7 days.Acute: this kind of is common, take flared, acute process and high death as feature.Sick pig lassitude, high fever; Do not eat, vomit; Conjunctival congestion; Ight soil is stiff, with mucus.Piggy later stage diarrhea.Ear, neck, back of the body flush, blue.On one's deathbed front oxter, strand in, have irregular cerise patch in abdomen, after finger pressure fades, merge together.Often dead in 3-4 days.Case fatality rate 80% left and right, the dead does not transfer rash piece type or chronic type to.When suckling pig and firm piggy generation brickpox of weaning, general sudden onset, performance nervous symptoms, twitches, and bites the dust, and the course of disease is no more than one day more.Subacute type (rash piece type): disease is lighter, an a couple of days, especially chest side, back, neck to whole body occurred that boundary is obvious at health different parts, and circular, quadrangle has the rash piece of hotness, is commonly called as " diamond-skin disease ", and finger pressure fades.Rash piece is given prominence to skin 2-3 millimeter, and approximately one to several centimetres of sizes from several to dozens of not etc., form brown crust after withered.Sick pig is thirsty, constipation, vomiting, fever.After rash piece occurs, body temperature starts to decline, and patient's condition alleviates, more than a few days down to ten days, and the rehabilitation voluntarily of sick pig.Also there are many sick pigs in pathogenic process, severity of symptoms and change septic into and dead.About 1-2 week of the course of disease.Chronic type: changed by acute or subacute type, also have primary, common are chornic arthritis, chronic endocarditis and cutaneous necrosis etc. several.Chornic arthritis type main manifestations is the inflammatory swelling of extremities joint (wrist, gambrel the most common compared with knee, hip joint), and sick leg is stiff, pain.Acute symptom disappears later, and take dysarthrasis as main, the broken row or the sleeping ground that present a limb or two limbs do not rise.Sick pig appetite is normal, but poor growth has a delicate constitution, and becomes thin.Course of disease several weeks or several months.Chronic endocarditis type main manifestations is become thin, anaemia, and asthenia universalis, happiness is sleeping, detests and walks about, and forces walking, and manner is slow, and whole body rocks.Auscultation heart has noise, palpitates quickly, hyperfunction, and cardiac arrhythmia, is short of breath.This kind of sick pig can not be cured, conventionally because heart is benumbed the death that falls down to the ground suddenly.Ulcer or the cabbage sample excipuliform natural disposition endocarditis of going to live in the household of one's in-laws on getting married.Cardiac arrhythmia, expiratory dyspnea, anaemia.Course of disease several weeks are to the several months.The brickpox of chronic type forms cutaneous necrosis sometimes.Often betide the portions such as the back of the body, shoulder, ear, hoof and tail.Local skin swelling, protuberance, necrosis, look black is, stiff, like leather.Separation with its lower floor's cambium gradually, just as one deck crust.Necrotic area sometimes scope is very large, can account for whole skin of back; Sometimes can necrose at part auricular concha, tail, tip, each coffin.Approximately through 2～3 months dead skin, come off, leave over a slice without hair, look light scar and heal.If any scabies secondary infection, state of an illness complexity, the course of disease extends.
Prevention at present and treatment brickpox medicine are PCs (Amoxicillin), cephalo-type (ceftiofur sodium).But the side effect of Western medicine is larger, and Western medicine only has obvious curative effect to single illness or a class illness in when treatment, and for the more disease of some illnesss, curative effect is not too obvious, usually needs out a lot of Western medicine, and price is higher; A lot of Chinese medicine is mainly from antibacterial, anti-inflammatory, clearing heat and detoxicating when treatment brickpox, and the many-sides such as ecchymose removing of invigorating blood circulation regulate body.Compared with antibiotic, Chinese medicine is non-simple antibacterial.Chinese medicine majority derives from natural plants, and its complicated component makes bacterium be difficult for producing drug resistance, is also difficult for causing medicament residue.Chinese medicine causes people's extensive concern in the effect preventing and treating aspect the white scour of piglet in recent years.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of for preventing and treating feed of brickpox and preparation method thereof, in feed, contain the Chinese medicine additive that is used for the treatment of brickpox, the control of brickpox disease is had evident in efficacy, side effect is low, cure rate is high, is difficult for the advantages such as recurrence.
In order to realize foregoing invention object, the invention provides the feed for preventing and treating brickpox, described feed comprises following raw material: barley, wheat, complex enzyme, yam flour, methionine, threonine, vitamin premix and Chinese medicine additive.
Described feed is comprised of the raw material of following parts by weight: barley 40-60 weight portion, wheat 30-40 weight portion, complex enzyme 5-9 weight portion, yam flour 10-20 weight portion, methionine 2-4 weight portion, threonine 2-4 weight portion, vitamin premix 4-6 weight portion and Chinese medicine additive 4-9 weight portion.
Described feed is comprised of the raw material of following parts by weight: barley 56 weight portions, wheat 33 weight portions, complex enzyme 7 weight portions, yam flour 15 weight portions, methionine 3 weight portions, threonine 3 weight portions, vitamin premix 5 weight portions and Chinese medicine additive 6 weight portions.
Described complex enzyme by dextranase, tie up plain enzyme, amylase forms; Vitamin premix main component is: vitamin A, vitamin D
3, vitamin E, vitamin K
3, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, folic acid, biotin, nicotinic acid, pantothenic acid, cottonseed protein, cornstarch, antioxidant and probiotics;
Described Chinese medicine additive is comprised of following raw medicinal material: honeysuckle, numb corruption, southern wild jujube, root of Chinese trichosanthes, garlic, potato, ant, Da Lunmu, rheum officinale, glutinous rice, talcum, blackberry lily, subprostrate sophora, folium isatidis, lepidium seed, the root bark of tree peony, radix rehmanniae recen, radix scrophulariae, Radix Glycyrrhizae, almond, Chinese violet, catkin, duckweed, alum and dandelion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: honeysuckle 10～20 weight portions, rotten 18～28 weight portions of fiber crops, south wild jujube 10～26 weight portions, root of Chinese trichosanthes 10～20 weight portions, garlic 10～20 weight portions, potato 10～15 weight portions, ant 10～20 weight portions, reach logical sequence wood 10～26 weight portions, rheum officinale 10～20 weight portions, glutinous rice 10～15 weight portions, talcum 10～26 weight portions, blackberry lily 10～25 weight portions, subprostrate sophora 10～15 weight portions, folium isatidis 10～20 weight portions, lepidium seed 10～20 weight portions, the root bark of tree peony 10～24 weight portions, radix rehmanniae recen 10～26 weight portions, radix scrophulariae 10～20 weight portions, Radix Glycyrrhizae 10～24 weight portions, almond 10～24 weight portions, Chinese violet 10～20 weight portions, catkin 10～20 weight portions, duckweed 10～15 weight portions, alum 10～15 weight portions and dandelion 10～20 weight portions.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: honeysuckle 12～17 weight portions, rotten 19～25 weight portions of fiber crops, south wild jujube 14～22 weight portions, root of Chinese trichosanthes 13～18 weight portions, garlic 12～17 weight portions, potato 10～15 weight portions, ant 15～20 weight portions, reach logical sequence wood 15～26 weight portions, rheum officinale 10～15 weight portions, glutinous rice 10～15 weight portions, talcum 10～18 weight portions, blackberry lily 10～21 weight portions, subprostrate sophora 10～15 weight portions, folium isatidis 10～17 weight portions, lepidium seed 10～16 weight portions, the root bark of tree peony 12～20 weight portions, radix rehmanniae recen 13～18 weight portions, radix scrophulariae 13～18 weight portions, Radix Glycyrrhizae 13～21 weight portions, almond 15～21 weight portions, Chinese violet 12～17 weight portions, catkin 12～18 weight portions, duckweed 13～15 weight portions, alum 13～15 weight portions and dandelion 13～17 weight portions.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: honeysuckle 15 weight portions, rotten 23 weight portions of fiber crops, south wild jujube 18 weight portions, root of Chinese trichosanthes 15 weight portions, garlic 15 weight portions, potato 13 weight portions, ant 17 weight portions, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portions, glutinous rice 13 weight portions, talcum 14 weight portions, blackberry lily 15 weight portions, subprostrate sophora 12 weight portions, folium isatidis 15 weight portions, lepidium seed 13 weight portions, the root bark of tree peony 16 weight portions, radix rehmanniae recen 15 weight portions, radix scrophulariae 16 weight portions, Radix Glycyrrhizae 17 weight portions, almond 18 weight portions, Chinese violet 15 weight portions, catkin 15 weight portions, duckweed 14 weight portions, alum 14 weight portions and dandelion 15 weight portions.
Described Chinese medicine additive also comprises following bulk drug: dried orange peel, husky, cloves and hawthorn.
Described Chinese medicine additive is comprised of following bulk drug: honeysuckle 12～17 weight portions, rotten 19～25 weight portions of fiber crops, south wild jujube 14～22 weight portions, root of Chinese trichosanthes 13～18 weight portions, garlic 12～17 weight portions, potato 10～15 weight portions, ant 15～20 weight portions, reach logical sequence wood 15～26 weight portions, rheum officinale 10～15 weight portions, glutinous rice 10～15 weight portions, talcum 10～18 weight portions, blackberry lily 10～21 weight portions, subprostrate sophora 10～15 weight portions, folium isatidis 10～17 weight portions, lepidium seed 10～16 weight portions, the root bark of tree peony 12～20 weight portions, radix rehmanniae recen 13～18 weight portions, radix scrophulariae 13～18 weight portions, Radix Glycyrrhizae 13～21 weight portions, almond 15～21 weight portions, Chinese violet 12～17 weight portions, catkin 12～18 weight portions, duckweed 13～15 weight portions, alum 13～15 weight portions, dandelion 13～17 weight portions, dried orange peel 10～15 weight portions, husky 10～20 weight portions in ground, cloves 10～20 weight portions and hawthorn 10～20 weight portions.
Described Chinese medicine additive is comprised of following bulk drug: honeysuckle 15 weight portions, rotten 23 weight portions of fiber crops, south wild jujube 18 weight portions, root of Chinese trichosanthes 15 weight portions, garlic 15 weight portions, potato 13 weight portions, ant 17 weight portions, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portions, glutinous rice 13 weight portions, talcum 14 weight portions, blackberry lily 15 weight portions, subprostrate sophora 12 weight portions, folium isatidis 15 weight portions, lepidium seed 13 weight portions, the root bark of tree peony 16 weight portions, radix rehmanniae recen 15 weight portions, radix scrophulariae 16 weight portions, Radix Glycyrrhizae 17 weight portions, almond 18 weight portions, Chinese violet 15 weight portions, catkin 15 weight portions, duckweed 14 weight portions, alum 14 weight portions, dandelion 15 weight portions, dried orange peel 13 weight portions, husky 15 weight portions in ground, cloves 15 weight portions and hawthorn 15 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, pack in multi-function extractor, the ethanol that to add with respect to the determining alcohol of 3～5 times of mixture qualities be 80%～90%, adds hot reflux and extracts for 1 hour～3 hours, obtains extract, the steam pressure adding in thermal reflow process is 0.4MPa～0.6MPa, and extracting liquid filtering is obtained to the first filtered fluid and filter residue;
Second step, the ethanol that it is 80%～90% that the filter residue that the first step is obtained adds with respect to the determining alcohol of 1～3 times of first step mixture quality, add hot reflux and extract for 0.5 hour～1.5 hours, obtain extract, the steam pressure adding in thermal reflow process is 0.4MPa～0.6MPa, and extracting liquid filtering is obtained to the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, are ground into 200 order～400 orders subsequently, obtain Chinese medicine additive powder.
In order better to realize foregoing invention object, the invention provides a kind ofly for preventing and treating the preparation method of feed of brickpox, described preparation method comprises the following steps:
(1) broken step: take by weight percentage barley and wheat and drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into yam flour, methionine, threonine, vitamin premix and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again;
(5) spraying step: complex enzyme is sprayed to the pellet surface after fragmentation.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains the Chinese medicine additive that is used for the treatment of brickpox, Chinese medicine additive is take clearing heat-fire, Yin-nourishing and body fluid promoting, the regulating blood condition of regulating the flow of vital energy, function of spleen and stomach regulating as primary treatment principle, with other feedstuff actings in conjunction, work in coordination, to brickpox, control has evident in efficacy, side effect is low, the advantages such as cure rate is high, short treating period, difficult recurrence.
The specific embodiment
Chinese medicine is mainly by antibacterial, improves immunity of organisms, strengthens resistance against diseases, anti-inflammatory, and mitigation symptoms, keeps gastrointestinal bacterial flora balance, and gastrointestinal peristalsis inhibition improves body blood physical and chemical index etc. and is used for treating brickpox.According to traditional Chinese veterinary medicine theory, the morbidity of brickpox is relevant with many factors, and pig physique is weak, climate change, and diet problem etc. all can.Traditional Chinese veterinary medicine from deficiency of vital energy blood-head opinion it, ying-qi is empty and can not promote blood, therefore blood-head row and overflow channels and collaterals and occur extravasated blood spot in vain or owing to hindering body fluid in heat, causes body fluid exhaustion, Jin Dynasty doctor Liu Wansu think: the kidney being a water ZANG-organ, heat of void, actually cold.The heart is that fire is dirty, by the restriction of kidney water, therefore advocate to support the treatment rule of kidney watery diarrhea internal heat.Supporting kidney water is to effect a permanent cure, and purge the sthenic heart-fire is to take stopgap measures.The former sick formula > > of < < Plain Questions arcane truth: " elimnation for excess and tonification for deficiency, flat." brickpox mainly uses heat-clearing and fire-clearing drug, the more important thing is and reuse Yin-nourishing and body fluid promoting medicine.Qi and blood is obstructed, and all kinds of diseases and ailments are raw, stagnation of QI and blood may bring about pain, and ying-qi weakness during brickpox, can not promote blood, and warm blood is gone outside channels and collaterals, therefore produce blood cake rash in vain.Therefore brickpox is treated the regulating blood condition of regulating the flow of vital energy, ecchymose removing promoting eruption.By impelling QI-blood circulation, make the interior various nutritional labelings of body in vivo gradually to best configuration.The spleen being the foundation of acquired constitution, spleen is the mother in dirty, taste, as tree root, do not have the biochemical action of spleen, all dirty nutrition that loses, life cannot exist, and stomach, for receiving Gu Zhihai, does not have the effect of stomach, and spleen cannot carry out biochemical transporting, so be also noted that function of spleen and stomach regulating.
According to above-mentioned principle, the present invention is take clearing heat-fire, Yin-nourishing and body fluid promoting, the regulating blood condition of regulating the flow of vital energy, function of spleen and stomach regulating as primary treatment principle, provide a kind of for preventing and treating the feed that contains Chinese medicine additive of brickpox, Chinese medicine additive comprises following raw medicinal material: honeysuckle, numb corruption, southern wild jujube, root of Chinese trichosanthes, garlic, potato, ant, Da Lunmu, rheum officinale, glutinous rice, talcum, blackberry lily, subprostrate sophora, folium isatidis, lepidium seed, the root bark of tree peony, radix rehmanniae recen, radix scrophulariae, Radix Glycyrrhizae, almond, Chinese violet, catkin, duckweed, alum and dandelion.
In side, the pharmacology of each bulk drug is as follows:
Honeysuckle: taste is sweet, cold in nature, enters the heart, lung, stomach, large intestine channel, has clearing heat and detoxicating effect, and double can removing heat from the blood and relieve diarrhea is mainly used in affection of exogenous wind-heat, the hot poison of warm heat disease is contained, or warm disease is from the beginning of heat evil still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; The malicious diarrhea of heat, the lower blood of stool; Heat temperature card; The sore carbuncle that hot poison gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has good antipyretic effect, has antiinflammatory action, can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis.
Fiber crops are rotten: sharp stomach, relieving heat toxin, grows beneficial marrow, the most sharp old man.Profit flesh, laxation, removing toxic substances.
South wild jujube: taste is sweet; Acid; Property is put down.Return spleen; Liver Channel.Function cures mainly: the promoting flow of qi and blood circulation; Mental-tranquilization; Disappear long-pending; Removing toxic substances.Main qi depression to blood stasis; Pectoralgia; Palpitation; Neurasthenia; Insomnia; Bronchitis; Eat stagnant abdomen full; Diarrhoea; Hernia; Burn and scald.
Root of Chinese trichosanthes: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing heat and promoting fluid, detumescence and apocenosis.For pyreticosis polydipsia, lung-heat type cough, interior heat is quenched one's thirst, sore swollen toxin.< < detailed outline > >: radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore the profit of quenching the thirst is withered, fire falls in micro-hardship, does not sweetly injure one's stomach, former times people only says its bitter cold, like deeply not examining.< < book on Chinese herbal medicine converges says > >: root of Chinese trichosanthes, move back the five internal organs hot and suffocating, as internal heat, contain and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, spleen fire is contained and dispute tooth is swollen, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.If the side of body of irascibility is swollen, walk note, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer bursts and do not burst, and hot poison is loose, or five subcutaneous ulcer yellow skin and eyes, and if if little water drenches puckeryly, be due to all burning hot pent-up, convulsive seizure due to phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control yearningly, controls empty yearningly from tonic, controls fire thirsty from the medicine of a cold nature, controls strongly fragrant yearningly from gas medicine, from blood medicine, controls polydipsia, is to control thirsty key medicine also.
Garlic: warm in nature, taste is pungent flat; Enter spleen, stomach, lung channel.Removing toxic substances desinsection, swelling and pain relieving, antidiarrheal is stopped dysentery, controls lung, and expelling parasite also has warm spleen to warm up stomach in addition.Control swollen ulcer drug, white bald tinea sore, dysentery is had loose bowels, tuberculosis pertussis, roundworm pinworm, eating accumulation, coldness and pain in the epigastrium, oedema turgor, promoting the circulation of qi disappears long-pending, desinsection removing toxic substances.For flu, bacillary dysentery, amoebic dysentery, enteritis, eating accumulation, the swollen sore of carbuncle.Strong disinfecting: in garlic, sulfur-containing compound has strong antibacterial and anti-inflammation functions, all has and suppresses and killing action multiple coccus, bacillus, fungi and virus etc., is the strongest one of antibacterial action in the natural plants of finding at present.Anti-curing oncoma and cancer: the elements such as the germanium in garlic and selenium can inhibition tumor cell and the growth of cancer cell, experiment finds, the crowd that cancer incidence is minimum is exactly the highest crowd of selenium content in blood.American National cancer tissue thinks, in the plant of the anticancer potentiality of tool in the whole world, what rank first is garlic.Toxin-expelling intestine-cleaning, prevention of intestinal gastric disease: garlic can effectively suppress and kill the bacterial virus such as helicobacter pylori that causes gastrointestinal disease, removes stomach noxious material, and stimulating gastrointestinal mucous membrane, promotes appetite, accelerates digestion.Reduce blood sugar, prevention diabetes: garlic can promote the secretion of insulin, increase the absorption of histocyte to glucose, improve human glucose tolerance, reduce rapidly blood sugar level in body, and can kill the various germs because of infection-induced diabetes, thereby effectively prevent and treat diabetes.Control cardiovascular and cerebrovascular disease: garlic can prevent the fat deposition in cardiovascular and cerebrovascular, the metabolism of induced tissue fat inside, significantly increase FA, reduce cholesterol, suppress hematoblastic gathering, reduce PC, increase arteriolar expansion ratio, impel vasodilation, regulate blood pressure, increase the permeability of blood vessel, thereby suppress formation and the prevention of arterial sclerosis of thrombus.Eating 2 ~ 3 lobe garlics every day, is the preferably the most easy way of step-down, and garlic can help the right quantity of a kind of enzyme in holder and avoid occurring hypertension.
Potato: taste is sweet; Property is put down.Function cures mainly: in strong with stomach; Removing toxicity for detumescence.Main stomachache; Zha rib; Carbuncle is swollen; Eczema; Scald.
Ant: taste is salty; Acid; Property is put down.Return liver; Kidney channel.Function cures mainly: tonifying kidney and benefiting sperm; Clearing and activating the channels and collaterals; Removing toxicity for detumescence.The main dizzy tinnitus of suffering from a deficiency of the kidney; Insomnia and dreamful sleep; Impotence and seminal emission; Arthralgia due to wind-dampness; Hemiplegia 6; Numb in every limb; Erythematosus lupus; Chorionitis; Dermatomyositis; The carbuncle furunculosis that swells; Venomous snake bite.
Reach logical sequence wood: acid; Pungent; Micro-hardship; Tepor.Function cures mainly: the detumescence of dispeling the wind; Blood stasis removing analgesic.Main traumatic injury; Treating rheumatic ostealgia; Stomach and intestine angina; Cellulitis; Abscess; Stomatitis.
Rheum officinale: cure mainly real hot constipation; The thermojunction feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhoea; Oedema abdomen is full; Difficult urination; Hot eyes; Abscess of throat; Aphthae; Gastropyretic vomiting; Spit blood; Spitting of blood; Bleeding from five sense organs or subcutaneous tissue; Have blood in stool; Hematuria; Hold blood; Through closing; The stagnant stomachache of the stasis of blood in postpartum; A lump in the abdomen causing distension and pain; Traumatic injury; The malicious large carbuncle of heat; Erysipelas; Scald.
Glutinous rice: sweet, temperature.Cure mainly tonifying middle-Jiao and Qi, controlling quenches one's thirst urinates manyly, and spontaneous perspiration, just lets out.Few for insufficiency of the spleen food, weak loose stool, hysteria of womam.Immunosuppressive action: the alcohol extract of date with every days 100 mg to rat oral gavage, show date there is same immunosuppressive action with imuran, to atopic diseases, can suppress the generation of antibody.Date alcohol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to inhibitory action.The two glucoside A of flavones in date, pharmacological evaluation proves to have calmness, hypnosis and hypotensive effect, date to have the effect that increases cAMP in white blood cell.Date decoction can reduce the damage of CCl4 to liver.
Talcum: sweet, light, cold.Return bladder, lung, stomach warp.Function cures mainly: inducing diuresis for treating strangurtia, clearing away summerheat, clearing damp sore.For heat, drench, urolithiasis, urinates hot puckery pain, summer-heat and damp polydipsia, damp and hot watery diarrhea; Control eczema outward, wet sore, prickly heat.
Blackberry lily: bitter, cold in nature, return lung, Liver Channel, have clearing heat and detoxicating, the effect of clear phlegm relieve sore throat, for the malicious convulsive seizure due to phlegm-fire pent-up of heat, abscess of throat, accumulation and obstruction of sputum, the cards such as cough and asthma, blackberry lily is commonly used to treat the disease of respiratory tract, Chang Zuowei main ingredient in the compound of antiviral property breathing problem.Osajin in blackberry lily and triterpene substance are its main antiviral ingredients.At present in blackberry lily, isoflavone like substance has been reported 30 multiple compounds.Osajin composition has anti-inflammatory, removes free radical, the developing of the pneumonia due to the effect such as antibacterial, antiviral and anti-oxidant, and reduces inflammation, and herpesviral I institute cytopathogenic effect is had to delayed-action.According to relevant report, the triterpenoid saponin constituents in blackberry lily has the generation that strengthens Cellular Immunity, enhancing antibody and complement, regulates the effects such as cell factor.
Subprostrate sophora: hardship, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: clearing heat and detoxicating, and detumescence relieve sore throat.For fiery poison, pent up abscess of throat, gingivitis.
Folium isatidis: be mainly used in heat poison and send out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.This medicine extensive use clinically in recent years, controls above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, both can be applied to prevention by single, can coordinate again radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, radix rehmanniae recen etc., can removing summer-heat gas divide, seek the heat poison dividing, availablely control various encephalitis, and comparatively suitable with partial heat type.< < detailed outline > >: " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." the positive > > of < < book on Chinese herbal medicine: " and control the hot poison of pestilence and go mad, wind-heat macula, large carbuncle swells and ache, relieving thirst and restlessness, only nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.All with the heat malicious person that holds concurrently, all should blue leaf smash juice and use it.”
Lepidium seed: pungent; Bitter; Cold.Return lung channel; The heart channel of Hang-Shaoyin; Liver Channel; Stomach warp; Urinary bladder channel.Function: purging the lung of pathogenic fire sending down abnormally ascending; Eliminating phlegm and relieving asthma; Inducing diuresis for removing edema; Let out by heresy.Cure mainly: sputum is stopped up the dyspnea and cough with excessive sputum of lung; Lung carbuncle; Oedema; Chest abdomen ponding; Difficult urination; Chronic cor pulmonale; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
The root bark of tree peony: < < Compendium of Materia Medica > >: " nourishing Yin and falling fire, separate spot poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of moutan bark has inhibition Platelet; Paeonol has the effects such as the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolysis and antiatherosclerosis, diuresis, antiulcer.
Radix rehmanniae recen: there is anti-inflammatory, anti-allergic effects.Glutinous rehmannia decoction gavage has obvious antagonism to big white mouse formaldehyde arthritis and albumen arthritis, and can suppress the increase of the capillary permeability that granuloma that turpentine oil hypodermic injection causes and histamine cause. the mouse peritoneum inflammation that the vasopermeability that Rehmannia glutinosa Libosch Water extract causes histamine increases and acetic acid causes has obvious inhibitory action, egg white induced Acute inflammation is also had to antiinflammatory action, and the alcohol of glutinous rehmannia and ether extract are without antiinflammatory action.Have antifungic action, Rehmannia glutinosa Libosch Water preserved material has inhibitory action to the growth of the multiple fungies such as trichophyton mentagrophytes, gypsum sample microspore tinea bacterium, ulotrichy microspore's tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand.There is the inhibitory action of antagonism dexamethasone to Pituitary Adrenal cortex system, and can promote the synthetic of cortex hormone of aadrenaline.
Radix scrophulariae: there is antibacterial action.In vitro, radix scrophulariae has inhibitory action to trichophyton mentagrophytes, acrothesium floccosum and ulotrichy microspore tinea bacterium.Radix scrophulariae water logging agent (1:3) also has inhibitory action to Austria Du big belly microspore tinea bacterium in vitro.Experiment shows: the inhibitory effect beguine of radix scrophulariae leaf is strong, wherein particularly evident to staphylococcus aureus.
Radix Glycyrrhizae: property is flat, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Almond: hardship, tepor.Relieving cough and asthma, relax bowel.Antibechic, antiasthmatic effect, for cough and asthma.This product master enters lung channel.Bitter can fall, and holds concurrently and dredge the property opened of profit, falls to have the merit of a surname's lung concurrently among lung qi and reach relieving cough and asthmaly, for controlling, coughs the key medicine of breathing heavily.With card compatibility, can be used for multiple cough illness card.As chill, cough and breathe heavily, compatibility Chinese ephedra, Radix Glycyrrhizae, with dispersing wind and cold, freeing lung and relieving asthma, i.e. Sanao tang.Cough due to wind-heat evil, compatibility mulberry leaf, chrysanthemum, with the wind-heat of faling apart, the cough-relieving of a surname's lung, as Sang Ju Yin.Cough caused by dryness-heat, compatibility mulberry leaf, the bulb of fritillary, the root of straight ladybell, with clearing away the lungheat and moisturizing cough-relieving, as sangxing decoction.Lung heat is coughed and is breathed heavily, and compatibility gypsum etc. expels the heat-evil with clearing lung-heat, freeings lung and relieving asthma, as Ma Xing Shi Gan Tang.To the effect of digestive system, gas under almond bitter, and be rich in fat oil.Fat oil can improve the lubrication of intestinal contents to mucous membrane, therefore almond has the function relaxing bowel.Anti-inflammatory, analgesic activity, amarogentin decomposes the quiet styrax condensing enzyme of the benzaldehyde effect producing and generates styrax.Styrax has analgesic activity, and therefore the domestic people of having can remove patient's misery with semen armeniacae amarae treatment advanced liver cancer, and what have does not even need to take anodyne.Antitumor action, about the research of the antitumor mechanism of almond mainly contains following several respects: 1. a part of scholar thinks in cancer cell and contains a large amount of beta-glucosidases, and this enzyme can be hydrolyzed amarogentin and produce hydrogen cyanide (HCN), benzaldehyde and glucose.Because cancer cell lacks sulphur nitrile, generate enzyme, this enzyme has the detoxication to HCN, makes HCN become nontoxic sulphur nitrile compound, and normal cell lacks beta-glucosidase and contain a large amount of sulphur nitrile and generate enzyme.According to this theory, amarogentin should be able to selectively kill cancer cell, and almost harmless to normal cell.2. amarogentin can help the glutinous protein film of transparent sample of body endotrypsin digestion cancer cell, makes the more accessible cancer cell of leucocyte in body, and engulfs cancer cell.3. someone finds that the similar NaSCN of amarogentin and NaOCN can affect thymidine and enter liver tumor cell DNA and tumour cell to phosphate and amino acid whose absorption.Hypoglycemic activity, amarogentin has the effect that prevents and treats the diabetes that cause because of antineoplastic alloxan.Adopt alloxan to bring out mouse hyperglycaemia method and prove, survey blood sugar in advance after lumbar injection 3g/kg amarogentin 48h, result shows that the blood sugar that amarogentin can suppress due to alloxan specifically raises, and action intensity is relevant with the concentration of amarogentin in blood.Effect for reducing blood fat, clinical report, jordan almond can obviously reduce the blood lipid level of hyperlipemic patients, Spiller(1990) think that the monounsaturated fatty acids in almond contributes to reduce the slight blood fat raising of patient, and without strict dietary restriction.Beautification function, according to lung associating with skin and hair theory, can control from a surname's lung method opinion some disease of skin clinically, and compatibility eats almond, often obtains prompt effect.Modern study proves, in semen armeniacae amarae, contained fat oil can make keratoderma softening, thereby reaches the effect of beauty treatment.For the dry constipation of intestines, this product contains grease and matter profit, and bitter and lower gas, therefore can relax bowel.The Chang Peiwu seed of Oriental arborvitae, brush-cherry seed are equal to use, as the < < physicians from a family for generations obtain the wuren pills of efficacious prescriptions > >.
Chinese violet: hardship, cold. enter the heart, Liver Channel.Function cures mainly: clearing heat and promoting diuresis, removing toxicity for detumescence.Control furunculosis, carbuncle is swollen, scrofula, jaundice, dysentery, diarrhoea, hot eyes, larynx numbness, venomous snake bite.
Catkin: hardship; Cool in nature.Function cures mainly: cooling blood and hemostasis; Removing toxicity for eliminating carbuncles.Main haematemesis; Traumatic bleeding; Ulcer; Dislike sore.
Duckweed: pungent, cold.Return lung channel.Function cures mainly: dispelling wind-heat, promoting eruption, diuresis.For measles without adequate eruption, rubella itch, oedema oliguria.
Alum: nature and flavor are sour and astringent, cold, poisonous.Therefore have antibacterial action, astriction etc., can be used as Chinese medicine.Alum has another name called alum, is the refinement product of alunite.Alum sour-puckery flavor cold in nature, has stronger astriction, and the traditional Chinese medical science thinks that alum has removing toxic substances desinsection, and eliminating dampness is antipruritic, hemostasis antidiarrheal, the effect of heat-clearing dissolving phlegm.Studies confirm that in recent years, alum also has the effects such as antibacterial, anti-Trichomonas vaginalis.Antibacterial action alum has inhibitory action to multiple Grain-negative, positive coccus and bacillus; Common suppuration bacterium is had to stronger bacteriostasis. experiment shows: alum has inhibitory action (test tube method) to staphylococcus aureus, proteus. Escherichia coli, Pseudomonas aeruginosa, bacillus anthracis, Fu Shi and shigella, typhoid bacillus and paratyphoid A bacillus, proteus and staphylococcus etc. are had to inhibitory action (paper dish, flat band method); The strongest to viridans streptococci, hemolytic streptococcus, pneumococcus, corynebacterium diphtheriae effect, ox type Brucella, Bordetella pertussis, meningococcus effect are taken second place, to Bacillus influenzae without effect (paper disk method). high concentration alum steep also has inhibitory action to human-like (H37RV) and bacillus tuberculosis bovis. clinically with 0.75% alumen suspension to control burn wound charrin's disease effective.
Dandelion: there is the effect of resisting pathogenic microbes, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus in vitro, and Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, typhoid bacillus etc. and micrococcus catarrhalis are also had to certain bactericidal action.Dandelion extract (1:400) can suppress tulase in vitro.Dandelion water decoction (1:80) can delay ECHO11 virocyte pathology.Taraxol extract 31mg/kg can kill Leptospira.Water logging agent has inhibitory action to various skin fungi.Decoction, to Oral Administration in Rats, absorbs well, in urine, can keep certain antibacterial action.Also have protect the liver, the effect of cholagogic, by dandelion decoction gavage or with Dandelion Injectable Solution injection, the glutamic-pyruvic transaminase that carbon tetrachloride is caused raises obvious inhibitory action; Can significantly alleviate the Histological change that carbon tetrachloride liver damage causes.Have report to point out, dandelion has choleretic effect in animals.Dandelion liquid gavage can make gallbladder contraction, and oddi's sphincter is lax, is conducive to bile and enters in intestines.Effective to chronic gallbladder spasmolytic and calculosis clinically.Also there is immunologic function, dandelion decoction can significantly improve PBLC blast transformation rate in vitro, Taraxacum Polysaccharides can significantly strengthen ehrlich carcinoma and MM46 tumor-cell antigen induced mice foot pad delayed allergy intensity, and have an administration time more effective feature more backward, i.e. administration on the 11st～20th after antigenic stimulus or 2～20 the next day administration have obvious effect.Taraxacum Polysaccharides lumbar injection can significantly strengthen the CDCC of mouse antibodies dependence macrophage.
Chinese medicine additive of the present invention also comprises: dried orange peel, husky, cloves and hawthorn.
Dried orange peel: warm in nature, taste is pungent, bitter; Return spleen, lung channel, for diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, for lung qi, gather around the diseases such as the full and taste stagnation of the circulation of vital energy of stagnant, chest diaphragm ruffian, abdominal fullness and distention, for damp retention in middle-jiao, gastral cavity abdomen ruffian is swollen, have loose bowels in loose stool, and the phlegm disease such as cough more.Orange peel dispelling dampness with bitter and warm-natured drugs and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Be good at again eliminating dampness and eliminating phlegmly, for controlling wet phlegm, stop up the conventional key medicines of lung, the many coughs of phlegm, for insufficiency of the spleen diet reduce, indigestion, and the disease such as n and V.This product eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizing, indigestion, stool diarrhea, the fit applications such as normal and ginseng, the bighead atractylodes rhizome, Poria cocos.Can invigorating the spleen because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, orange peel again can with in, can control stomach Qi rising, n and V.
Ground is husky: property is flat, and taste is sweet.Function cures mainly: invigorating the spleen, moistening lung.
Cloves: in temperature, warm kidney, fall contrary.Cure mainly: control hiccup, vomiting, gastric disorder causing nausea, dysentery, trusted subordinate's crymodynia, Xuan addiction, hernia, ringworm.Meridian distribution of property and flavor: pungent, temperature.< < Kaibao Bencao > >: " taste is pungent, and temperature is nontoxic." enter stomach, spleen, kidney channel.< < Japan hanako materia medica > >: control implication, gastric disorder causing nausea, treats kidney qi, up-rushing gas syndrome, cloudy pain, establishing-Yang, warm waist knee, kills wine poison, and the Xuan addiction that disappears, except cold labor.
Hawthorn: cut into slices and dry, put in pot and use force large burnt brown, the inner yellowish-brown of frying to outside for spending, spraying clear water, taking-up is dried, and is charred FRUCTUS CRATAEGI.There is appetite-stimulating indigestion-relieving, change the effect of stagnant long-pending, the promoting blood circulation to remove blood stasis of disappearing, the promoting the circulation of qi of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, crataegolic acid, neat chrysanthemum tartaric acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral hawthorn can increase digestive ferment, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, hawthorn has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglycerides, atherosclerosis, but also can diastole coronary artery, increase myocardial contractive power, to anti-arrhythmia.Therefore, be conducive to prevent and treat hypertension, high fat of blood, artery sclerosis and coronary heart disease.
Embodiment 1 feed 1
The embodiment of the present invention provides a kind of feed that is used for the treatment of brickpox, and feed is comprised of the raw material of following parts by weight: barley 48 weight portions, wheat 40 weight portions, complex enzyme 9 weight portions, yam flour 13 weight portions, methionine 4 weight portions, threonine 4 weight portions, vitamin premix 5 weight portions and Chinese medicine additive 9 weight portions.
Wherein, complex enzyme is 1:1:1 by ratio of weight and number dextranase, tie up plain enzyme, amylase forms, vitamin premix main component is: retinol1 800IU/kg, vitamin D
3270 IU/kg, vitamin E 89 IU/kg, vitamin K
30.5mg/kg, Cobastab
12.8mg/kg, Cobastab
24mg/kg, Cobastab
62mg/kg, Cobastab
1221 μ g/kg, folic acid 0.6mg/kg, biotin 0.4mg/kg, nicotinic acid 29mg/kg, pantothenic acid 21mg/kg, cottonseed protein 8mg/kg, cornstarch 11mg/kg, antioxidant 2mg/kg and probiotics 5mg/kg, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: honeysuckle 15 weight portions, rotten 23 weight portions of fiber crops, south wild jujube 18 weight portions, root of Chinese trichosanthes 15 weight portions, garlic 15 weight portions, potato 13 weight portions, ant 17 weight portions, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portions, glutinous rice 13 weight portions, talcum 14 weight portions, blackberry lily 15 weight portions, subprostrate sophora 12 weight portions, folium isatidis 15 weight portions, lepidium seed 13 weight portions, the root bark of tree peony 16 weight portions, radix rehmanniae recen 15 weight portions, radix scrophulariae 16 weight portions, Radix Glycyrrhizae 17 weight portions, almond 18 weight portions, Chinese violet 15 weight portions, catkin 15 weight portions, duckweed 14 weight portions, alum 14 weight portions and dandelion 15 weight portions.
Wherein, the preparation method of Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, pack in multi-function extractor, the ethanol that to add with respect to the determining alcohol of 5 times of mixture qualities be 80%, adds hot reflux and extracts for 3 hours, obtains extract, the steam pressure adding in thermal reflow process is 0.4MPa, and extracting liquid filtering is obtained to the first filtered fluid and filter residue;
Second step, the ethanol that it is 80% that the filter residue that the first step is obtained adds with respect to the determining alcohol of 3 times of first step mixture qualities, adds hot reflux and extracts for 1.5 hours, obtains extract, the steam pressure adding in thermal reflow process is 0.4MPa, and extracting liquid filtering is obtained to the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that EAT is at 170 ℃, and 60 ℃ of leaving air temps, are ground into 400 orders subsequently, obtain Chinese medicine additive powder.
The feed link of the embodiment of the present invention is crossed following preparation method and is made:
(1) broken step: take by weight percentage barley and wheat and drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into yam flour, methionine, threonine, vitamin premix and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again;
(5) spraying step: complex enzyme is sprayed to the pellet surface after fragmentation.
Embodiment 2 feeds 2
It is a kind of for preventing and treating the feed of brickpox that the embodiment of the present invention provides, and consists of: barley 56 weight portions, wheat 33 weight portions, complex enzyme 7 weight portions, yam flour 15 weight portions, methionine 3 weight portions, threonine 3 weight portions, vitamin premix 5 weight portions and Chinese medicine additive 6 weight portions the raw material of following parts by weight.
Wherein, complex enzyme is 2:1:2 by ratio of weight and number dextranase, tie up plain enzyme, amylase forms, vitamin premix main component is: retinol1 800IU/kg, vitamin D
3270 IU/kg, vitamin E 89 IU/kg, vitamin K
30.5mg/kg, Cobastab
12.8mg/kg, Cobastab
24mg/kg, Cobastab
62mg/kg, Cobastab
1221 μ g/kg, folic acid 0.6mg/kg, biotin 0.4mg/kg, nicotinic acid 29mg/kg, pantothenic acid 21mg/kg, cottonseed protein 8mg/kg, cornstarch 11mg/kg, antioxidant 2mg/kg and probiotics 5mg/kg, Chinese medicine additive is comprised of following raw medicinal material: honeysuckle 15 weight portions, rotten 23 weight portions of fiber crops, south wild jujube 18 weight portions, root of Chinese trichosanthes 15 weight portions, garlic 15 weight portions, potato 13 weight portions, ant 17 weight portions, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portions, glutinous rice 13 weight portions, talcum 14 weight portions, blackberry lily 15 weight portions, subprostrate sophora 12 weight portions, folium isatidis 15 weight portions, lepidium seed 13 weight portions, the root bark of tree peony 16 weight portions, radix rehmanniae recen 15 weight portions, radix scrophulariae 16 weight portions, Radix Glycyrrhizae 17 weight portions, almond 18 weight portions, Chinese violet 15 weight portions, catkin 15 weight portions, duckweed 14 weight portions, alum 14 weight portions, dandelion 15 weight portions, dried orange peel 13 weight portions, husky 15 weight portions in ground, cloves 15 weight portions and hawthorn 15 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, pack in multi-function extractor, the ethanol that to add with respect to the determining alcohol of 4 times of mixture qualities be 85%, adds hot reflux and extracts for 2 hours, obtains extract, the steam pressure adding in thermal reflow process is 0.5MPa, and extracting liquid filtering is obtained to the first filtered fluid and filter residue;
Second step, the ethanol that it is 85% that the filter residue that the first step is obtained adds with respect to the determining alcohol of 2 times of first step mixture qualities, adds hot reflux and extracts for 1 hour, obtains extract, the steam pressure adding in thermal reflow process is 0.5MPa, and extracting liquid filtering is obtained to the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that EAT is at 180 ℃, and 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain Chinese medicine additive powder.
Toxicity test
1, acute toxicity test
According to acute toxicity test, require to carry out prerun, find that tested medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get 40 of above-mentioned mouse, fasting be can't help water after 12 hours, by body weight, be divided at random administration group and water control group, every group 20, administration group is given the liquid 0.4ml/10g of the crude drug amount 2.4g/ml concentration of the Chinese medicine additive of preparing containing embodiment 1, gavage one day 2 times, makes dosage in a day reach symphysis dose 192.0g/kg, and water control group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, all Continuous Observations seven days, the toxic reaction that record may occur and death condition, after administration, mouse outward appearance hair color light, behavioral activity is normal, without abnormal pathologic neural reflex, occur, in seven days, well, other Novel presentation is seen at end in feed, and changes of weight is no significant difference and none animal dead compared with water control group, visually observe the main organs such as the heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, result is as identical in the test result of embodiment 1 Chinese medicine additive.
Long term toxicity test
The Chinese medicine additive aqueous solution of the embodiment of the present invention 1 to mouse by 10.78,20.35 and 33.48g crude drug/kg (1.0ml/100g body weight that gavages continuously 16 weeks, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of the Chinese medicine additive of the embodiment of the present invention 1 to mouse, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine additive of the present invention is to mouse long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, result is as identical in the test result of embodiment 1 Chinese medicine additive.
Clinical testing
1.1 for examination material
1.1.1 for examination animal
In pig farm, Weifang City, Shandong Province, 150 of 3 monthly age of random choose sodium selenites.
1.1.2 strains tested
The individual raiser of Shandong Province pig, finds the piglet phenomena of mortality, other piglet lassitudes, high fever, does not eat, vomiting, conjunctival congestion, ight soil is stiff, with mucus, oxter, strand in, in abdomen, have irregular cerise patch, after finger pressure fades, merge together.After dead piglet is dissected, at the bottom of finding stomach and pyloric part film generation diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal or hemorrhagic inflammation in various degree, and splenomegaly is typical sepsis spleen.By pathological material of disease sterile samplings such as the livers of dead pig, inoculation blood agar medium, in the wet 24h that cultivates of 37 ℃ of constant temperature, observes colonial morphology, then selects suspicious bacterium colony and carries out pure culture.The tiny bacillus of the visible Gram-positive of microscopy, very thin shaft-like person is in the majority, easily forms long filament shape, the blunt circle in two ends, methylene blue dyeing is being the club shape of color depth, has long and bending thread thalline.The erysipelas bacillus being separated to is attacked to malicious two suckling pig, after 24 hours, find brickpox symptom, determine that dead piglet is that brickpox is lethal.Using the bacterial strain separating as strains tested.
1.1.3 for reagent product
The feed 1 of embodiment 1; The feed 2 of embodiment 2; Conventional medicament: Amoxicillin+qingkailing injections.
1.2 test method
1.2.1 inoculation test
By the erysipelas bacterial strain of cultivating respectively 134 of intravenous injections for examination piglet, infects and all occurs brickpox symptom after one day, selection wherein 120 ill piglets as experiment pig.
1.2.2 experiment grouping
120 ill piglets are divided into three groups at random, 40 every group, i.e. embodiment group 1, embodiment group 2 and control group.
1.2.3 test method
The piglet that occurs swine erysipelas after infection adopts respectively diverse ways treatment, and wherein, embodiment group 1 is used the feed 1 of the embodiment of the present invention 1 to treat, and uses continuously 4 days; Embodiment group 2 is used the embodiment of the present invention 2 feeds 2 to treat, and uses continuously 4 days; Control group is used Amoxicillin 2 grams/50 kg body weight+qingkailing injections, 20 milliliters/50 kg body weight, once a day, is used in conjunction 4 days, uses conventional feed to feed.
1.2.4 observed and recorded
Infect clinical symptoms and the pathological change of each group of piglet of rear observation, death toll and the result for the treatment of for the treatment of after finishing after record infects.
2 results
2.1 criterion of therapeutical effect
Cure: ill piglet spirit, appetite, body temperature, defecation all recover normally, the cerise patch in oxter, strand interior, abdomen all disappears;
Effective: ill piglet spirit, appetite, body temperature, defecation all recover normally, oxter, strand in, the red patch in abdomen is clearly better;
Invalid: it is even dead that ill piglet symptom does not disappear or sb.'s illness took a turn for the worse.
Wherein, efficient for curing and effective percentage sum.
2.2 observed results are as shown in table 1.
The table 1 treatment results table of comparisons
From the data of table 1: compared with control group, the feed of the embodiment of the present invention 1 and embodiment 2 has evident in efficacy to the treatment of brickpox, and side effect is low, the advantage that treated effect is high; In long-term observation subsequently, find, the piglet that embodiment group 1 and embodiment group 2 are cured the again incidence of disease is starkly lower than the piglet of control group.
2.3 infect rear symptom and cut open inspection result
After infection, the symptom of ill piglet is: lassitude, high fever, does not eat, vomiting, conjunctival congestion, ight soil is stiff, with mucus, oxter, strand in, in abdomen, have irregular cerise patch, after finger pressure fades, merge together.After dead piglet is dissected, at the bottom of finding stomach and pyloric part film generation diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal or hemorrhagic inflammation in various degree, and splenomegaly is typical sepsis spleen.
Concrete case
Case 1
Domestic 3 monthly age of two piglet of the Qin is found lassitude, do not eat, after one day, there is the phenomenon of high fever, vomiting and conjunctival congestion, occur two days later having cerise patch in oxter and abdomen, after finger pressure fades, merge together, be diagnosed as brickpox, use the forage feed of the embodiment of the present invention 1, feed in a conventional manner, use continuously 3 days, it is normal that two pig all recovers.
Case 2
27 suckling pigs on certain pig farm, there are the phenomena of mortality in 1 piglet, dead front oxter, strand in, have irregular cerise patch in abdomen, after fading, finger pressure merges together, after dead piglet is dissected, at the bottom of finding stomach and pyloric part film generation diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal or hemorrhagic inflammation in various degree, and splenomegaly is typical sepsis spleen, other piglets all have poor appetite, spirit is low, and the symptom of cerise patch appears in oxter, is diagnosed as brickpox, use the forage feed of the embodiment of the present invention 2, according to the normal mode of feeding, feed, use continuously 3 days, 23 piglets all recover normal, continual cure 2 days, other 4 piglets all recover normal.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. for preventing and treating the feed of brickpox, it is characterized in that, described feed comprises following raw material: barley, wheat, complex enzyme, yam flour, methionine, threonine, vitamin premix and Chinese medicine additive.
2. according to claim 1 for preventing and treating the feed of brickpox, it is characterized in that, described feed is comprised of the raw material of following parts by weight: barley 40-60 weight portion, wheat 30-40 weight portion, complex enzyme 5-9 weight portion, yam flour 10-20 weight portion, methionine 2-4 weight portion, threonine 2-4 weight portion, vitamin premix 4-6 weight portion and Chinese medicine additive 4-9 weight portion.
3. the feed that is used for the treatment of brickpox according to claim 1 and 2, it is characterized in that, described feed is comprised of the raw material of following parts by weight: barley 56 weight portions, wheat 33 weight portions, complex enzyme 7 weight portions, yam flour 15 weight portions, methionine 3 weight portions, threonine 3 weight portions, vitamin premix 5 weight portions and Chinese medicine additive 6 weight portions.
4. according to the feed that is used for the treatment of brickpox described in claim 1-3 any one, it is characterized in that, described Chinese medicine additive is comprised of following raw medicinal material: honeysuckle, numb corruption, southern wild jujube, root of Chinese trichosanthes, garlic, potato, ant, Da Lunmu, rheum officinale, glutinous rice, talcum, blackberry lily, subprostrate sophora, folium isatidis, lepidium seed, the root bark of tree peony, radix rehmanniae recen, radix scrophulariae, Radix Glycyrrhizae, almond, Chinese violet, catkin, duckweed, alum and dandelion.
According to described in claim 1-4 any one for preventing and treating the feed of brickpox, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: honeysuckle 10～20 weight portions, rotten 18～28 weight portions of fiber crops, south wild jujube 10～26 weight portions, root of Chinese trichosanthes 10～20 weight portions, garlic 10～20 weight portions, potato 10～15 weight portions, ant 10～20 weight portions, reach logical sequence wood 10～26 weight portions, rheum officinale 10～20 weight portions, glutinous rice 10～15 weight portions, talcum 10～26 weight portions, blackberry lily 10～25 weight portions, subprostrate sophora 10～15 weight portions, folium isatidis 10～20 weight portions, lepidium seed 10～20 weight portions, the root bark of tree peony 10～24 weight portions, radix rehmanniae recen 10～26 weight portions, radix scrophulariae 10～20 weight portions, Radix Glycyrrhizae 10～24 weight portions, almond 10～24 weight portions, Chinese violet 10～20 weight portions, catkin 10～20 weight portions, duckweed 10～15 weight portions, alum 10～15 weight portions and dandelion 10～20 weight portions.
According to described in claim 1-5 any one for preventing and treating the feed of brickpox, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: honeysuckle 12～17 weight portions, rotten 19～25 weight portions of fiber crops, south wild jujube 14～22 weight portions, root of Chinese trichosanthes 13～18 weight portions, garlic 12～17 weight portions, potato 10～15 weight portions, ant 15～20 weight portions, reach logical sequence wood 15～26 weight portions, rheum officinale 10～15 weight portions, glutinous rice 10～15 weight portions, talcum 10～18 weight portions, blackberry lily 10～21 weight portions, subprostrate sophora 10～15 weight portions, folium isatidis 10～17 weight portions, lepidium seed 10～16 weight portions, the root bark of tree peony 12～20 weight portions, radix rehmanniae recen 13～18 weight portions, radix scrophulariae 13～18 weight portions, Radix Glycyrrhizae 13～21 weight portions, almond 15～21 weight portions, Chinese violet 12～17 weight portions, catkin 12～18 weight portions, duckweed 13～15 weight portions, alum 13～15 weight portions and dandelion 13～17 weight portions.
7. according to the feed that is used for the treatment of brickpox described in claim 1-6 any one, it is characterized in that, described Chinese medicine additive also comprises following bulk drug: dried orange peel, husky, cloves and hawthorn.
8. according to the feed that is used for the treatment of brickpox described in claim 1-7 any one, it is characterized in that, described Chinese medicine additive is comprised of following bulk drug: honeysuckle 12～17 weight portions, rotten 19～25 weight portions of fiber crops, south wild jujube 14～22 weight portions, root of Chinese trichosanthes 13～18 weight portions, garlic 12～17 weight portions, potato 10～15 weight portions, ant 15～20 weight portions, reach logical sequence wood 15～26 weight portions, rheum officinale 10～15 weight portions, glutinous rice 10～15 weight portions, talcum 10～18 weight portions, blackberry lily 10～21 weight portions, subprostrate sophora 10～15 weight portions, folium isatidis 10～17 weight portions, lepidium seed 10～16 weight portions, the root bark of tree peony 12～20 weight portions, radix rehmanniae recen 13～18 weight portions, radix scrophulariae 13～18 weight portions, Radix Glycyrrhizae 13～21 weight portions, almond 15～21 weight portions, Chinese violet 12～17 weight portions, catkin 12～18 weight portions, duckweed 13～15 weight portions, alum 13～15 weight portions, dandelion 13～17 weight portions, dried orange peel 10～15 weight portions, husky 10～20 weight portions in ground, cloves 10～20 weight portions and hawthorn 10～20 weight portions.
9. according to the feed that is used for the treatment of brickpox described in claim 1-8 any one, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, pack in multi-function extractor, the ethanol that to add with respect to the determining alcohol of 3～5 times of mixture qualities be 80%～90%, adds hot reflux and extracts for 1 hour～3 hours, obtains extract, the steam pressure adding in thermal reflow process is 0.4MPa～0.6MPa, and extracting liquid filtering is obtained to the first filtered fluid and filter residue;
Second step, the ethanol that it is 80%～90% that the filter residue that the first step is obtained adds with respect to the determining alcohol of 1～3 times of first step mixture quality, add hot reflux and extract for 0.5 hour～1.5 hours, obtain extract, the steam pressure adding in thermal reflow process is 0.4MPa～0.6MPa, and extracting liquid filtering is obtained to the second filtered fluid;
The 3rd step, merges the first filtered fluid and the second filtered fluid, and reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, are ground into 200 order～400 orders subsequently, obtain Chinese medicine additive powder.
As described in claim 1-9 any one for preventing and treating the preparation method of feed for brickpox, it is characterized in that, described preparation method comprises the following steps:
(1) broken step: take by weight percentage barley and wheat and drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into yam flour, methionine, threonine, vitamin premix and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again;
(5) spraying step: complex enzyme is sprayed to the pellet surface after fragmentation.
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| CN107048007A (en) * | 2017-02-09 | 2017-08-18 | 安徽菲扬农业科技有限公司 | A kind of feed of prevention brickpox |
| CN107259153A (en) * | 2017-07-25 | 2017-10-20 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent feed of brickpox and preparation method thereof |
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| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
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| CN103416625A (en) * | 2013-08-05 | 2013-12-04 | 山东新希望六和集团有限公司 | Barley piglet feed and preparation method thereof |
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| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
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| CN107048007A (en) * | 2017-02-09 | 2017-08-18 | 安徽菲扬农业科技有限公司 | A kind of feed of prevention brickpox |
| CN107259153A (en) * | 2017-07-25 | 2017-10-20 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent feed of brickpox and preparation method thereof |
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| CN103719552B (en) | 2015-07-01 |
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