CN103704513A - Feed for treating swine plague and preparation method thereof - Google Patents
Feed for treating swine plague and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a feed for treating swine plague and a preparation method of the feed. The feed comprises corns, soybean meal, peanut meal, wheat bran, mountain flour, fish meal, sweet potato flour, kelp powder, vitamin E and a traditional Chinese medicinal additive. The feed has the beneficial effects that the feed provided by the invention comprises the traditional Chinese medicinal additive which is mainly used for clearing heat, detoxifying, ventilating the lung and resolving phlegm and assists in soothing the throat and diminishing inflammation to relieve pain; under the combined action, the traditional Chinese medicinal additive is matched with other raw materials, so that the feed has the advantages of obvious treating effect for treating the swine plague of pigs, high curing rate, poor side effect, difficulty in reappearing and low cost.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of feed that is used for the treatment of swine plague and preparation method thereof.
Background technology
Swine plague is by the caused a kind of acute infectious disease of multiple lethal Pasteurella (swine plague), is commonly called as " lockjawed laryngitis ", " swollen neck pest ".Acute or chronic process, the acute septicemia that is changes, bottleneck throat swelling, highly expiratory dyspnea.Pasteurella multocida can infect many animals, and pig is wherein a kind of, and the pig at various ages all can infection morbidity.It is generally acknowledged that this bacterium is a kind of conditionity pathogen, when pig is in bad external environment, as cold, sultry, weather drastic change, humidity, crowded, improper ventilation, nutritional deficiency, fatigue, long-distance transport etc., cause the resistance of pig to decline, at this moment pathogen breeds and causes morbidity in a large number.Sick pig, through discharges of bacteria such as secretion, excretas, pollutes drinking-water, feed, apparatus and external environment in addition, through alimentary canal, is transmitted to health pig, is also the important routes of infection.Also can discharge cause of disease by cough, sneeze, by the spittle through respiratory tract infection.In addition, hematophagus bites skin and mucous membrane wound all can infect.This disease is general without significantly seasonal, but colding and heat succeed each other, climate variability, high temperature season is multiple, is generally sporadic or endemicity.
To many animals and have per capita pathogenic, with the susceptible of pig, without obvious seasonal generation, but to cold and heat succeed each other, weather drastic change, humidity, the factors such as rainy generation is more, and malnutrition, long-distance transport, raising condition change, bad promote this disease to occur, and often concentrate and fall ill.
According to course of disease length and clinical manifestation, be divided into the most acute, acute and chronic type.Acute: there is not any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows hyperthermia to 41～42 ℃, and appetite is useless absolutely, expiratory dyspnea, heartbeat rapidly, visual mucous membrane cyanosis, there is purplish-red macula in skin.Bottleneck throat and neck heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, and is often sitting position of dog gesture, extends neck, sometimes can send the sound of stridulating, and mouth and nose flow out white foam, sometimes with color.Once there is serious expiratory dyspnea, the state of an illness often worsens rapidly, very fast dead.Death rate Chang Gaoda 100%, and spontaneous remission person is rare.Acute: this type is the most common.Hyperthermia to 40～41 ℃, the initial stage is spastic dry cough, expiratory dyspnea, mouth and nose flow out foam, are sometimes mixed with blood, after become wet cough.With disease, breathe more difficultly, often make sitting position of dog gesture, chest palpation has pain.Lassitude, poor appetite or absolutely useless, there is erythema in skin, later stage languishment does not rise sleepingly, how because of death by suffocation.The course of disease 5～8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis., there is continuation cough in time and has difficulty in breathing, and has a little hydrodynamic or purulence nose liquid.Arthroncus, often has diarrhoea, poor appetite, and malnutrition, has scab sample eczema, and growth stops, skeletonize, the course of disease is more than 2 weeks, and most generations are dead.
Be 1-5 days general incubation period.Acute, night is normal food also, and m seq is dead, often can't see reveal any symptoms, and the course of disease is slightly long, hyperthermia is to 41-42 ℃, and appetite is absolutely useless, and asthenia universalis does not rise sleepingly, expiratory dyspnea, be sitting position of dog gesture, mouth and nose flow out foam, course of disease 1-2 day, the death rate 100%.Acute (pleuropneumonia type), body temperature 40-41 ℃, spastic dry cough, discharges sputum and is mucus or purulence, expiratory dyspnea, rear one-tenth is wet, pain is coughed, and chest pain is that dog sits, dog is sleeping, first constipation, rear diarrhoea, visible extravasated blood blood spots on skin.Chronic type, continuing has cough, expiratory dyspnea, nose flows a small amount of mucus, sometimes occurs arthroncus, become thin, diarrhoea, dead through more than 2 weeks exhaustion, the most acute and acute pig of case fatality rate 60-70%. shows as septicemia and pleuropneumonia.Affected pig portion is red and swollen, expiratory dyspnea, mucous membrane and skin cyanosis, body temperature 41-42 ℃, course of disease 1-2 day.Chronic type is shown in persistent cough, expiratory dyspnea, and suppurating property nose liquid, becomes thin, exhaustion.Acute: whole body mucous membrane, serous coat and hypodermis have blutpunkte, the hemorrhagic oedema of larynx and surrounding tissue thereof of especially take is feature.Cut skin of neck, have the yellowish or grey cyan fiber disposition slurries of a large amount of glue peptone samples.Lymph nodes of body as a whole swelling, hemorrhage.On the external membrane of heart and pericardium, there is blutpunkte.Lung acute edema.Spleen has hemorrhage but not enlargement.Skin has blood spots.Bleeding of gastrointestinal mucosa inflammation.Acute: except having the pathology of acute, its distinctive pathology is fibrinous pneumonia.Main manifestations is in tracheae, bronchus, to have volume foam mucus.Lung has Gan Bian district in various degree, with wind-puff and oedema.The long Fei Ganbian of the course of disease often has necrosis region in district, and between lobulus pulmonis, serosity infiltrates, and lung tangent plane is marble sample outward appearance, and pleura has fiber disposition attachment, pleura and sick adhesion of lung.Thoracic cavity and hydropericardium.Chronic type: corpse skeletonize, anaemia.Lungs You Ganbian district, and have yellow or grey necrosis region, there is connective tissue outside, includes caseous substance; Some formation cavity, communicates with bronchus.Pericardium and pleural effusion, thoracic cavity has fiber disposition calm, and pleura is plump, usually with sick adhesion of lung.Sometimes at intercostal muscle, bronchus peripheral lymph node, mediastinal lymph nodes and tonsillotome, joint and hypodermis, see there is necrosis region.Acute: except the hemorrhagic pathology of whole body mucous membrane, organa parenchymatosum, lymph node, distinctive pathology is fibrinous pneumonia, has Gan Bian district in various degree.Pleura and adhesion of lung, lung tangent plane is marble grain, thoracic cavity, hydropericardium, tracheae, tunica mucosa bronchiorum inflammation have foam-like mucus.Chronic type: Fei Ganbian district expands, has lark or grey downright bad, inside has caseous substance, and some formation cavity, highly becomes thin, anaemia, and hypodermis is shown in necrosis region.
Morbus acutissimus example, because morbidity is anxious, often has little time treatment, sick pig dead.Penicillin, streptomysin and Cyclomycin family antibiotic have certain curative effect to swine plague.Antibiotic and sulfa drug share, as tetracycline+sulfadimidine, and tylosin+sulfadimidine.In treatment, be stressed that especially, this bacterium very easily develops immunity to drugs, and therefore with good conditionsily should do drug sensitive test, selects sensitive medicaments treatment.Prevention: the annual spring and autumn of (1) epidemic prevention regularly carries out immunity inoculation twice with swine plague aluminium hydroxide formaldehyde vaccine or the oral weak toadstool seedling of swine plague.Also can select brickpox, swine plague aluminium hydroxide bigeminy seedling, swine fever, brickpox, the weak malicious triple vaccine of swine plague.Vaccine inoculation a few days ago with latter 7 days in, forbidding antibacterials.(2) improve feeding and management in the situation that of conditions permit, advocate early weaning.The production routine of the all-in and all-out system of employing; Enclosed swinery, reduces and draws from the outside pig; The measures such as density that reduce swinery may be helpful to controlling the meeting of this disease.(3) chemoprophylaxis, to regular incidence pig farm, be added antimicrobial and prevent in feed.According to this sick propagating characteristic, first anti-system should strengthen the premunition of body.Strengthen feeding and management, elimination may reduce resistance against diseases factor and pathogenic inducement is as crowded in colony house, ventilation and lighting is poor, moist, catch cold etc.Colony house, environment are regularly sterilized.After new introduction pig quarantines one month, health can be gregarious.Carrying out immunization campaign, is these sick important measures of prevention, regularly carries out every year planned inoculation.The swine plague vaccine of producing at present has five kinds of swine plague inactivated vaccines, the weak toadstool seedling of swine plague Inner Mongol system, swine plague eo-630 live vaccine, swine plague ta53 live vaccine, swine plague c20 live vaccine, use, preservation and points for attention by specification.While there is this disease, should be by sick pig isolation, blockade, tightly sterilization.With the pig on hurdle, with serum or with vaccine, promptly prevent.To distributing disease pig, should isolate for treatment, sterilization pig house.To after newly buying pig and quarantining one month without the gregarious raising of ANOMALOUS VARIATIONS.Treatment can adopt following medicine:
1, penicillin 80-240 ten thousand intramuscular injection use 10-20 milliliters of 10% sulphadiazines to inject 5-10 milliliters of intramuscular injection of water simultaneously, and 12 hours once, is used in conjunction 3 days.
2,45 kilograms of above 2500 milligrams, chloramphenicol, 3000 milligrams of streptomysins, 20 milliliters of intramuscular injection of 10% aminopyrine for pig, 6 hours 1 time, are used in conjunction 2 times.
3, gentamicin 1-2 mg/kg body weight, tetracycline 7-15 mg/kg body weight, every day 2 times, until temperature decline.
Western medicine easily develops immunity to drugs, and Chinese medicine has no side effect, without the resistance to the action of a drug, its role is to, the qi and blood of conditioning engine body, smooth the liver and regulate the spleen, metabolic function and the immunologic function of adjustment body, there is again antivirus action, therefore body recovery is fast, do not recur after more, by herbal control swine plague, be the problem of the concentrated research of many veterinary work persons in recent years.The Chinese medicine of developing at present be not as good as Western medicine, therefore has report that Western medicine and Chinese traditional medicine composition are used to the treatment curative effect of swine plague, though it has advantages of relative low price, effective speed is slower, when medicine time is longer, just can make transference cure.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of feed that swine plague contains Chinese medicine additive that is used for the treatment of, and to suffering from the treatment of swine plague, has evident in efficacyly, treats both principal and secondary aspect of disease, and cure rate is high, and side effect is little, the advantage that cost is low.
In order to realize foregoing invention object, the invention provides a kind of feed that is used for the treatment of swine plague, it is characterized in that, described feed comprises following raw material: corn, dregs of beans, peanut meal, wheat bran, stone flour, fish meal, tapioca flour, Kelp Powder, vitamin E and Chinese medicine additive.
Described feed is preferably comprised of the raw material of following parts by weight: corn 50-80 weight portion, dregs of beans 50-60 weight portion, peanut meal 30-50 weight portion, wheat bran 20-30 weight portion, stone flour 10-30 weight portion, fish meal 10-20 weight portion, tapioca flour 10-30 weight portion, Kelp Powder 20-40 weight portion, vitamin E 5-10 weight portion and Chinese medicine additive 5-18 weight portion.
Described feed is preferably comprised of the raw material of following parts by weight: corn 75 weight portions, dregs of beans 55 weight portions, peanut meal 41 weight portions, wheat bran 26 weight portions, stone flour 19 weight portions, fish meal 15 weight portions, tapioca flour 21 weight portions, Kelp Powder 32 weight portions, vitamin E 7 weight portions and Chinese medicine additive 12 weight portions.
Described Chinese medicine additive comprises following bulk drug: subprostrate sophora, Lasiosphaera fenzlii, the coptis, cape jasmine, the root of large-flowered skullcap, pollen, the dried immature fruit of citron orange, rheum officinale, radix scrophulariae, felwort, akebi, the capsule of weeping forsythia, balloonflower root, the compound of glauber-salt and liquorice, the larva of a silkworm with batrytis, cup chrysanthemum, lepidium seed, perillaseed, fritillaria thunbergii, manyleaf meadowure rhizome and root, betel nut and birthwort.
Described Chinese medicine additive is preferably comprised of the bulk drug of following parts by weight: subprostrate sophora 11～20 weight portions, Lasiosphaera fenzlii 11～25 weight portions, the coptis 11～45 weight portions, cape jasmine 10～16 weight portions, the root of large-flowered skullcap 10～16 weight portions, pollen 10～15 weight portions, the dried immature fruit of citron orange 10～15 weight portions, rheum officinale 10～16 weight portions, radix scrophulariae 10～20 weight portions, felwort 10～15 weight portions, akebi 10～15 weight portions, the capsule of weeping forsythia 10～20 weight portions, balloonflower root 10～15 weight portions, the compound of glauber-salt and liquorice 10～15 weight portions, the larva of a silkworm with batrytis 10～15 weight portions, cup chrysanthemum 10～15 weight portions, lepidium seed 10～15 weight portions, perillaseed 10～20 weight portions, fritillaria thunbergii 10～15 weight portions, manyleaf meadowure rhizome and root 10～15 weight portions, betel nut 10～15 weight portions and birthwort 10～15 weight portions.
Described Chinese medicine additive is preferably comprised of the bulk drug of following parts by weight: subprostrate sophora 15 weight portions, Lasiosphaera fenzlii 18 weight portions, the coptis 29 weight portions, cape jasmine 13 weight portions, the root of large-flowered skullcap 13 weight portions, pollen 12 weight portions, the dried immature fruit of citron orange 12 weight portions, rheum officinale 13 weight portions, radix scrophulariae 15 weight portions, felwort 12 weight portions, akebi 13 weight portions, the capsule of weeping forsythia 15 weight portions, balloonflower root 13 weight portions, the compound of glauber-salt and liquorice 13 weight portions, the larva of a silkworm with batrytis 12 weight portions, cup chrysanthemum 12 weight portions, lepidium seed 13 weight portions, perillaseed 15 weight portions, fritillaria thunbergii 13 weight portions, manyleaf meadowure rhizome and root 12 weight portions, betel nut 12 weight portions and birthwort 13 weight portions.
Described Chinese medicine additive also comprises fibert, corn stigma, rue, rock wind and Radix Glycyrrhizae, described Chinese medicine additive is comprised of the bulk drug of following ratio of weight and number: subprostrate sophora 15～20 weight portions, Lasiosphaera fenzlii 12～25 weight portions, the coptis 20～35 weight portions, cape jasmine 10～16 weight portions, the root of large-flowered skullcap 10～16 weight portions, pollen 10～15 weight portions, the dried immature fruit of citron orange 10～15 weight portions, rheum officinale 10～16 weight portions, radix scrophulariae 11～15 weight portions, felwort 11～15 weight portions, akebi 11～15 weight portions, the capsule of weeping forsythia 11～15 weight portions, balloonflower root 11～15 weight portions, the compound of glauber-salt and liquorice 10～15 weight portions, the larva of a silkworm with batrytis 10～15 weight portions, cup chrysanthemum 11～15 weight portions, lepidium seed 10～15 weight portions, perillaseed 11～18 weight portions, fritillaria thunbergii 11～15 weight portions, manyleaf meadowure rhizome and root 11～15 weight portions, betel nut 11～15 weight portions, birthwort 11～14 weight portions, fibert 11～14 weight portions, corn stigma 10～15 weight portions, rue 11～14 weight portions, rock wind 10～15 weight portions and Radix Glycyrrhizae 15～35 weight portions.
Described Chinese medicine additive is preferably comprised of the bulk drug of following ratio of weight and number: subprostrate sophora 18 weight portions, Lasiosphaera fenzlii 19 weight portions, the coptis 32 weight portions, cape jasmine 13 weight portions, the root of large-flowered skullcap 13 weight portions, pollen 12 weight portions, the dried immature fruit of citron orange 12 weight portions, rheum officinale 13 weight portions, radix scrophulariae 13 weight portions, felwort 13 weight portions, akebi 12 weight portions, the capsule of weeping forsythia 13 weight portions, balloonflower root 13 weight portions, the compound of glauber-salt and liquorice 12 weight portions, the larva of a silkworm with batrytis 12 weight portions, cup chrysanthemum 13 weight portions, lepidium seed 13 weight portions, perillaseed 15 weight portions, fritillaria thunbergii 13 weight portions, manyleaf meadowure rhizome and root 13 weight portions, betel nut 13 weight portions, birthwort 12 weight portions, fibert 13 weight portions, corn stigma 12 weight portions, rue 13 weight portions, rock wind 13 weight portions and Radix Glycyrrhizae 25 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water adding is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 order～400 orders, obtain Chinese medicine additive powder.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the described feed that is used for the treatment of swine plague, described preparation method comprises the following steps:
Take by ratio of weight and the number of copies all raw materials, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Drop into granulator and granulate, pelleting temperature is 65-80 ℃, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 8-15 order.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed provided by the invention comprise take clearing heat and detoxicating, ventilating the lung and resolving phlegm as main, take tonneau throat, anti-inflammatory analgetic is auxiliary Chinese medicine additive, Chinese medicine additive and other raw materials cooperatively interact, acting in conjunction, to suffer from the treatment of the pig of swine plague have advantages of evident in efficacy, cure rate is high, side effect is little, be difficult for recurrence, cost is low.
The specific embodiment
According to clinical manifestation and course of disease process, can be divided into the most acute, acute and chronic three types.The most acute: there is not any symptom, sudden onset, dead rapidly.The course of disease slightly elder shows hyperthermia to 41～42 ℃, and appetite is useless absolutely, expiratory dyspnea, heartbeat rapidly, visual mucous membrane cyanosis, there is purplish-red macula in skin.Bottleneck throat and neck heating, red and swollen, hard, severe patient is extended down to the basal part of the ear, front.Sick pig breathes and is the devil, and is often sitting position of dog gesture, extends neck, sometimes can send the sound of stridulating, and mouth and nose flow out white foam, sometimes with color.Once there is serious expiratory dyspnea, the state of an illness often worsens rapidly, very fast dead.Death rate Chang Gaoda 100%, and spontaneous remission person is rare.Acute: this type is the most common.Hyperthermia to 40～41 ℃, the initial stage is spastic dry cough, expiratory dyspnea, mouth and nose flow out foam, are sometimes mixed with blood, after become wet cough.With disease, breathe more difficultly, often make sitting position of dog gesture, chest palpation has pain.Lassitude, poor appetite or absolutely useless, there is erythema in skin, later stage languishment does not rise sleepingly, how because of death by suffocation.The course of disease 5～8 days, the dead does not transfer to chronic.Chronic type: main manifestations is pneumonia and chronic gastroenteritis., there is continuation cough in time and has difficulty in breathing, and has a little hydrodynamic or purulence nose liquid.Arthroncus, often has diarrhoea, poor appetite, and malnutrition, has scab sample eczema, and growth stops, skeletonize, the course of disease is more than 2 weeks, and most generations are dead.Chinese veterinarian thinks, swine plague is many catches a cold because feeding and management is bad and weather fusion is suffered from cold or suffers from other diseases, body healthy tendency is impaired, defend outer ability and reduce, disease and evil is invaded lung through mouth and nose and is defended, and heat is evaporated poison so that qi depression to blood stasis, then heat symptoms caused by an exopathgen upper punch throat, so that pharyngitis heat pain, convulsive seizure due to phlegm-fire is strongly fragrant in lung channel, impairment of dispersing and descending function of the lung and cause the circulation of vital energy in the wrong direction and cough and breathe heavily, have difficulty in breathing; Heat enters ying blood, sees skin erythema etc.That treatment swine plague disease should be take is clearing heat and detoxicating, ventilating the lung and resolving phlegm as main, take tonneau throat, anti-inflammatory analgetic as auxiliary.
According to above-mentioned theory and principle, the invention provides a kind of feed that is used for the treatment of swine plague, feed comprises Chinese medicine additive; Wherein, Chinese medicine additive comprises subprostrate sophora, Lasiosphaera fenzlii, the coptis, cape jasmine, the root of large-flowered skullcap, pollen, the dried immature fruit of citron orange, rheum officinale, radix scrophulariae, felwort, akebi, the capsule of weeping forsythia, balloonflower root, the compound of glauber-salt and liquorice, the larva of a silkworm with batrytis, cup chrysanthemum, lepidium seed, perillaseed, fritillaria thunbergii, manyleaf meadowure rhizome and root, betel nut and birthwort.
The pharmacological property of each raw material is as follows:
Subprostrate sophora: hardship, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: clearing heat and detoxicating, and detumescence relieve sore throat.For fiery poison, pent up abscess of throat, gingivitis.
Lasiosphaera fenzlii: pungent, flat.Function cures mainly: heat-clearing, relieve sore throat, hemostasis.Cure mainly: sphagitis, tonsillitis; Traumatism and bleeding is controlled in external application, hemorrhoid hemorrhage pernio.
The coptis: heat-clearing and damp-drying drug, purging intense heat and detonicating.Full for damp and hot ruffian, vomiting acid regurgitation, rushes down dysentery, jaundice, and unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head is told nosebleed, hot eyes, toothache, quenches one's thirst, the carbuncle furunculosis that swells; Control eczema outward, wet sore, duct is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of prepared RHIZOMA COPTIDIS with vino is burning hot.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach and stomach preventing or arresting vomiting.For fever and chills, tie mutually, damp and hot middle resistance, ruffian is completely vomitted.The easypro liver of the cornel coptis and stomach preventing or arresting vomiting.For liver-stomach disharmony, vomiting acid regurgitation.Damp and hot for endoretention of damp heat, stomach, vomit, rush down the diseases such as dysentery.Join the root of large-flowered skullcap, rheum officinale etc., can control the card of endoretention of damp heat.To the damp and hot stomach of being reluctant to leave, often coordinate the tuber of pinellia, caulis bambusae in taenian; Join the banksia rose, the root of large-flowered skullcap, the root of kudzu vine etc. and rush down dysentery to control.
Cape jasmine: bitter, cold in nature, enter the heart, lung, three warmers, have the effect of relieving restlessness purging intense heat, soothing liver-qi stagnation, clearing heat and promoting diuresis, cooling blood and hemostasis, be mainly used in the strongly fragrant chest gastral cavity of warm heat disease heat vexed uneasiness, bother not peaceful; Liver depression is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, hot eyes dry throat; Jaundice with damp-heat pathogen; The symptoms such as the abdominal distention of qi depression to blood stasis, the heat conduction of cape jasmine tonneau three warmers is descending, and has anti-hepatic lesion effect.
The root of large-flowered skullcap: have heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by root of large-flowered skullcap extract effect.< < Bencao Jingshu > >: the root of large-flowered skullcap, its property is respectful clearly, so evil removing: so bitter eliminating dampness; So cold sensation of the genitalia victory heat, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from by, source is clearly flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber, makes us obstructed through closing, damp and hot solution, Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is stayed knot, and is that the swollen stain of carbuncle is also rotten: fiery ulcer person, internal heat blood trouble also, cool blood heat extraction, self-healing also.
Pollen: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing heat and promoting fluid, detumescence and apocenosis.For pyreticosis polydipsia, lung-heat type cough, interior heat is quenched one's thirst, sore swollen toxin.< < detailed outline > >: radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore the profit of quenching the thirst is withered, fire falls in micro-hardship, does not sweetly injure one's stomach, former times people only says its bitter cold, like deeply not examining.< < book on Chinese herbal medicine converges says > >: root of Chinese trichosanthes, move back the five internal organs hot and suffocating, as internal heat, contain and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, spleen fire is contained and dispute tooth is swollen, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.If the side of body of irascibility is swollen, walk note, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer bursts and do not burst, and hot poison is loose, or five subcutaneous ulcer yellow skin and eyes, and if if little water drenches puckeryly, be due to all burning hot pent-up, only convulsive seizure due to phlegm-fire, falls in this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control yearningly, controls empty yearningly from tonic, controls fire thirsty from the medicine of a cold nature, controls strongly fragrant yearningly from gas medicine, from blood medicine, controls polydipsia, is to control thirsty key medicine also.
The dried immature fruit of citron orange: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: relieving stagnant Qi disappears long-pending, the loose ruffian of reducing phlegm.For in stagnant, stop, the full distending pain of ruffian, rushes down after dysentery heavyly, suffer from constipation, and the stagnant vapour lock obstruction of qi in the chest of phlegm, accumulation of pathogens in chest; Gastroptosis, prolapse of the anus, the prolapse of uterus.
Rheum officinale: cure mainly real hot constipation; The thermojunction feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhoea; Oedema abdomen is full; Difficult urination; Hot eyes; Abscess of throat; Aphthae; Gastropyretic vomiting; Spit blood; Spitting of blood; Bleeding from five sense organs or subcutaneous tissue; Have blood in stool; Hematuria; Hold blood; Through closing; The stagnant stomachache of the stasis of blood in postpartum; A lump in the abdomen causing distension and pain; Traumatic injury; The malicious large carbuncle of heat; Erysipelas; Scald.
Radix scrophulariae: taste is sweet, bitter, salty; Cold nature.Return lung, stomach, kidney channel.Clearing heat and cooling blood, purging intense heat and detonicating, enriching yin.Temperature heresy is joined the army, the pericardium that caves in, and febrile virulent maculae, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder that constipation, hectic fever due to yin labor are coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.There is clearing heat and cooling blood, removing toxic substances, dissipating bind relieve sore throat, the effect of enriching yin.Be used for: warm heat disease heat enters ying blood the card of consumption of YIN caused by febrile disease.There is clearing heat and cooling blood, the effect of removing toxic substances enriching yin.
Felwort: hardship, cold.Return liver, gallbladder channel.Function cures mainly: heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire.For jaundice with damp-heat pathogen, swelling of vulva pruritus vulvae, under band, persistent erection, eczema itch, hot eyes, deafness, hypochondriac pain, bitter taste, convulsion.
Akebi: bitter, be slightly cold.Enter the heart channel of Hang-Shaoyin, small intestinl channel, urinary bladder channel.There is clearing away the heart-fire, diuresis, the effect of the lactogenesis of stimulating the menstrual flow.For irritable feverish sensation in chest, larynx numbness pharyngalgia, urinates redly, and five drench, oedema, whole body contraction pain is few through closing breast.Heat is drenched puckery pain, oedema.This product energy inducing diuresis for removing edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Treatment bladder damp-heat, scanty drak urine, drenches the puckery pain of drop, the adapteds such as normal and plantain seed, talcum; For oedema, be equipped with umbellate pore furgus, the root bark of white mulberry is equal to use.Aphthae, vexed urine is red.The fire of this product energy supernatant the heart channel of Hang-Shaoyin, under let out small intestine heat.Often control flaring up of heart fire, aphthae, or intestines and the disease such as the vexed urine that causes is red under heart-fire moving downward, the adapteds such as many and radix rehmanniae recen, Radix Glycyrrhizae, the leaf of bamboo.Few through closing breast.These product lactogenesis of stimulating the menstrual flow.With controlling blood stasis through closing, join safflower, peach kernel, the red sage root and be equal to use; If deficient or obstructed with controlling milk, can be equal to use with the seed of cowherb, pangolin; These product can also sharp blood vessels, get round by bribery, and join ramulus mori, coix seed is equal to use, treatment damp-heat arthralgia pain.
The capsule of weeping forsythia: bitter, cold nature, enters the heart, liver, courage, small intestinl channel, have clearing heat and detoxicatingly, the effect of dispersing swelling and dissipating binds, for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched the treatment of the cards such as renal shutdown, and shigella dysenteriae, staphylococcus aureus are had to very strong inhibitory action.
Balloonflower root: bitter; Pungent; Property is put down.Return lung channel.Effect: a surname's lung, eliminate the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, fill blood, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility.Cure mainly: coughing with a lot of sputum, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache, aphthae, red eye, swell pain, uroschesis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, hoarsen, lung carbuncle pyemesis, sore purulence does not become to burst.Energy expelling phlegm and arresting coughing, and have a surname's lung, apocenosis effect.The direct stimulation of contained platycodin to oral cavity, throat, gastric mucosa, makes sputum dilution thereby reflectivity ground increases tunica mucosa bronchiorum hypersecretion, is easy to discharge; Balloonflower root has antitussive effect, has the anti-inflammatory of enhancing and immunization, and its anti-inflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrocyte, improves lysozyme activity; Stress ulcer is had to prevention effect.The thick saponin(e of balloonflower root has calmness, analgesia, refrigeration function, again can hypoglycemic, norcholesterol, and relaxing smooth muscle.Platycodin has very strong haemocylolysis, but destroy and lose haemocylolysis oral can decomposition in alimentary canal.
The compound of glauber-salt and liquorice: salty, bitter, cold.Return stomach, large intestine channel.Function cures mainly: purgating heat and bowels, moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat.For real hot constipation, dry feces, stagnant stomachache; Control abscess of throat outward, aphthae, swelling and aching of gum, hot eyes, carbuncle is swollen, erysipelas.
The larva of a silkworm with batrytis: taste is pungent; Salty; Property is put down.Return liver; Lung; Stomach warp.Function cures mainly: expelling wind and relieving convulsion; Reducing phlegm and resolving masses; Removing toxic substances relieve sore throat.Main epilepsy seizures; the oblique of outlet eyes; prejudiced headache; sore throat; scrofula; mumps; rubella; sore.1. anticonvulsant action: 10% decocting liquid 2g/kg is oral to mouse, and the convulsions that strychnine nitrate is caused has obvious antagonism.The mixture (i.e. the decoction of five brave Chinese medicine Zhuifengsans) being comprised of the commercially available larva of a silkworm with batrytis, cicada slough etc. can reduce strychnine, pentylenetetrazol, cocaine, and nicotine etc. cause the death toll of mice convulsion.Artificial larva of a silkworm with batrytis decoction also has the effect of the mice convulsion due to antagonism strychnine.2. syngignoscism: alcohol water-leach liquor has syngignoscism to mouse and rabbit, the oral 0.5g/20g of mouse, hypodermic injection 0.25g/20g, approximates the hypodermic hypnosis effect of 50mg/kg phenobarbital.3. the pharmacological action of stiff pupa: the convulsions that stiff pupa antagonism small white mouse is caused by strychnine nitrate, effect is that significantly result is consistent with the larva of a silkworm with batrytis.Aspect the reduction death rate, test group and control group difference are not obvious, but stiff pupa is consistent with the result of the larva of a silkworm with batrytis.In two results, stiff pupa is all slightly better than the larva of a silkworm with batrytis.In addition, stiff pupa still can suppress small white mouse S-180 (need further affirm), though staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa etc. are had to inhibitory action, DeGrain.Due to, stiff pupa convenient sources, therefore can be in order to replace the larva of a silkworm with batrytis.4. the pharmacological research of silkworm king: the toxicity of silkworm king is very low.Teenage male mice body weight gain is had to facilitation, can obviously increase prostate one sperm-storing bag of castration mouse and castrated rats, the weight of preputial gland, show to there is androgen-like action.
Cup chrysanthemum: clearing heat and detoxicating, anti-inflammation hemostasia, dehumidifying diuresis, desinsection.Cure mainly acute gastroenteritis, heatstroke, cystitis, urethritis, sphagitis, stomatitis, spits blood, bleeding from five sense organs or subcutaneous tissue.
Lepidium seed: pungent, bitter, Great Cold.Return lung, urinary bladder channel.Function cures mainly: removing heat from lung and relieving asthma, line water detumescence.For sputum, stop up lung, dyspnea and cough with excessive sputum, fullness in chest and hypochondrium, must not put down sleepingly, and chest ascites is swollen, difficult urination; Cor pulmonale oedema.
Perillaseed: pungent, temperature.Return lung, large intestine channel.Function cures mainly: sending down abnormally ascending dissolving phlegm, and relieving cough and asthma, relax bowel.For phlegm, stop up the circulation of vital energy in the wrong direction, cough and asthma, the dry constipation of intestines.Pharmacological action: 1, the effect to blood fat, with the feed containing perilla herb oil, feed chicken, can make chicken plasma cholesterol levels reduce, but mouse is acted on without this, and cause the depilation of mouse neck and skin lesion; With the feed containing perilla herb oil, feed rabbit, can increase its body weight and liver weight, but the cholesterol level of blood plasma and liver is had no significant effect.2, bacteriostasis: experiment shows: perilla herb oil (0.1%) all has inhibitory action to the mould of proteus, black-koji mould, Penicillium notatum and occurring in nature. wherein to the nipalgin of the obviously strong what 0.05% of the effect of yeast and mold and 0.3% benzoic acid.3, anticorrosion, antioxidation: the ethanol extract of perilla seed after degreasing has anticorrosion and antioxidation.The long-term storage of available what food and medicine. its antioxidation is strong compared with 0.02% BHT (2,6-di-t-butyl p-Hydroxybenzylalcohol).
Fritillaria thunbergii: hardship, cold.Return lung, the heart channel of Hang-Shaoyin.Function cures mainly: heat-clearing dissipating bind, and preventing phlegm from forming and stopping coughing, for wind-heat affecting lung, phlegm-fire cough, lung carbuncle, acute mastitis, scrofula, sore.
Manyleaf meadowure rhizome and root: hardship, cold.Function cures mainly: heat-clearing and damp-drying drug, purging intense heat and detonicating.For enteritis, dysentery, jaundice, red eye, swell pain.
Betel nut: bitter; Pungent; Warm in nature.Return stomach; Large intestine channel.Effect, expelling parasite; Disappear long-pending; Lower gas; Row water; Preventing malaria.Malnutrition due to parasitic infestation; Eat stagnant; Abdominal distention; After rushing down dysentery, weigh; Beriberi; Oedema; Malaria.Resisting pathogenic microbes effect betel nut infusion (1:1) in vitro to trichophyton, permitted the dermatophytes such as blue achorion and had inhibitory action in various degree.Decoction and some strain of water logging agent infected by influenza A type have certain inhibitory action, and antiviral effect may be relevant with wherein contained tannin.
Birthwort: have clearing lung-heat sending down abnormally ascending, the effect that relieving cough and asthma, gut purge disappears hemorrhoid, its stem claims herba aristolochiae to have to regulate the flow of vital energy, the effect of clearing damp, promoting blood circulation and stopping pain, and its root claims dutchmanspipe root to have the effect of promoting qi circulation and relieving pain, removing toxicity for detumescence.
Chinese medicine additive of the present invention preferably also comprises: fibert, corn stigma, rue, rock wind and Radix Glycyrrhizae.
Fibert: sweet, flat.1. < < Kaibao Bencao > >: " taste is sweet, flat, nontoxic." 2. > > is wanted in the bun of < < medical center: " is sweet salty, flat." function cures mainly: in tune, and appetizing, improving eyesight.1. Cui Yu tin < < cuisine canon > >: " three worms are gone in the improving eyesight of food." 2. < < Japan hanako materia medica > >: " fertile white man, only hungry, in tune, appetizing." 3. < < Kaibao Bencao > >:, " main beneficial strength, wide stomach make us not hungry, hike."
Corn stigma: sweet, light, flat.Return bladder, liver, gallbladder channel.Function cures mainly: inducing diuresis to reduce edema, flat liver cholagogic.For acute and chronic ephritis, oedema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic nasosinusitis, lithangiuria, Biliary Calculi, the diseases such as difficult urination, damp and hot jaundice.And can prevent habitual abortion.
Rue: pungent, micro-hardship, cool.Function cures mainly: clearing heat and detoxicating, and blood stasis removing analgesic.For cold, fever, toothache, irregular menstruation, infantile eczema; Sore furuncle poison, traumatic injury are controlled in external application.
Rock wind: hardship; Cool.Function cures mainly: promoting diuresis for stranguria; Clearing heat and detoxicating.Main stranguria; Oedema; Acute mastitis; Sore
Radix Glycyrrhizae: property is flat, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Embodiment 1 Chinese medicine additive 1
The embodiment of the present invention provides a kind of Chinese medicine additive that is used for the treatment of swine plague, Chinese medicine additive is comprised of the raw material of following parts by weight: subprostrate sophora 15 weight portions, Lasiosphaera fenzlii 18 weight portions, the coptis 29 weight portions, cape jasmine 13 weight portions, the root of large-flowered skullcap 13 weight portions, pollen 12 weight portions, the dried immature fruit of citron orange 12 weight portions, rheum officinale 13 weight portions, radix scrophulariae 15 weight portions, felwort 12 weight portions, akebi 13 weight portions, the capsule of weeping forsythia 15 weight portions, balloonflower root 13 weight portions, the compound of glauber-salt and liquorice 13 weight portions, the larva of a silkworm with batrytis 12 weight portions, cup chrysanthemum 12 weight portions, lepidium seed 13 weight portions, perillaseed 15 weight portions, fritillaria thunbergii 13 weight portions, manyleaf meadowure rhizome and root 12 weight portions, betel nut 12 weight portions and birthwort 13 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 36 hours, with slow fire boiling, decocting time is 2.5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 3 times, decoct 1 hour at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that EAT is at 180 ℃, and 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain Chinese medicine additive powder.
Embodiment 2 Chinese medicine additives 2
The embodiment of the present invention 2 provides a kind of Chinese medicine additive that is used for the treatment of swine plague, Chinese medicine additive comprises the raw material of following parts by weight: subprostrate sophora 18 weight portions, Lasiosphaera fenzlii 19 weight portions, the coptis 32 weight portions, cape jasmine 13 weight portions, the root of large-flowered skullcap 13 weight portions, pollen 12 weight portions, the dried immature fruit of citron orange 12 weight portions, rheum officinale 13 weight portions, radix scrophulariae 13 weight portions, felwort 13 weight portions, akebi 12 weight portions, the capsule of weeping forsythia 13 weight portions, balloonflower root 13 weight portions, the compound of glauber-salt and liquorice 12 weight portions, the larva of a silkworm with batrytis 12 weight portions, cup chrysanthemum 13 weight portions, lepidium seed 13 weight portions, perillaseed 15 weight portions, fritillaria thunbergii 13 weight portions, manyleaf meadowure rhizome and root 13 weight portions, betel nut 13 weight portions, birthwort 12 weight portions, fibert 13 weight portions, corn stigma 12 weight portions, rue 13 weight portions, rock wind 13 weight portions and Radix Glycyrrhizae 25 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 30 hours, with slow fire boiling, decocting time is 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2 times, decoct 2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that EAT is at 190 ℃, and 80 ℃ of leaving air temps, are ground into 400 orders subsequently, obtain Chinese medicine additive powder.
Embodiment 3 feeds 1
The embodiment of the present invention provides a kind of feed that is used for the treatment of swine plague, consists of: corn 75 weight portions, dregs of beans 55 weight portions, peanut meal 41 weight portions, wheat bran 26 weight portions, stone flour 19 weight portions, fish meal 15 weight portions, tapioca flour 21 weight portions, Kelp Powder 32 weight portions, vitamin E 7 weight portions and Chinese medicine additive 12 weight portions the raw material of following parts by weight.
Wherein, Chinese medicine additive is the Chinese medicine additive 1 of embodiment 1.
The preparation method of feed is as follows:
Take by ratio of weight and the number of copies all raw materials, drop into pulverizer and pulverize, grinding particle size is 30 orders;
Drop into granulator and granulate, pelleting temperature is 70 ℃, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 10 orders.
Embodiment 4 feeds 2
The embodiment of the present invention provides a kind of feed that is used for the treatment of swine plague, consists of: corn 50 weight portions, dregs of beans 50 weight portions, peanut meal 50 weight portions, wheat bran 20 weight portions, stone flour 23 weight portions, fish meal 10 weight portions, tapioca flour 30 weight portions, Kelp Powder 40 weight portions, vitamin E 5 weight portions and Chinese medicine additive 7 weight portions the raw material of following parts by weight.
Wherein, Chinese medicine additive is the Chinese medicine additive 2 of embodiment 2.
The preparation method of feed is as follows:
Take by ratio of weight and the number of copies all raw materials, drop into pulverizer and pulverize, grinding particle size is 40 orders;
Drop into granulator and granulate, pelleting temperature is 80 ℃, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 15 orders.
Acute toxicity test
40 of application NIH mouse, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mouse is divided into two groups at random, and 20 every group, control group and administration group, test front fasting 12 hours; The Chinese medicine additive of embodiments of the invention 1 preparation is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mouse toxic reaction and death toll.Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal.Mouse oral administration gavage tablet LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By batheroom scale: the dosis tolerata of mouse (average weight take 20g) oral administration gavage Chinese medicine of the present invention is quantity 901 times.Therefore the acute toxicity of the embodiment of the present invention 1 Chinese medicine additive is low, clinical drug safety.Take the Chinese medicine additive test method identical as object adopts of the embodiment of the present invention 2, result proves that the acute toxicity of embodiment 2 Chinese medicine additives is low equally, clinical drug safety.
Long term toxicity test
The embodiment of the present invention 1 Chinese medicine additive to mouse by 10.78,20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the Chinese medicine additive of the embodiment of the present invention 1 all has no significant effect indexs such as the hair of mouse, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.The Chinese medicine additive that the embodiment of the present invention 1 is described to mouse long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.Take the Chinese medicine additive test method identical as object adopts of the embodiment of the present invention 2, the Chinese medicine additive that result proves embodiment 2 equally to mouse long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.
Clinical testing
1.1 for examination material
1.1.1 for examination animal
On pig farm, Qingdao, Shandong Province, choose at random 225 healthy growing and fattening pigs, as experiment pig.
1.1.2 for prelibation strain
Pig Pasteurella C44-41 and standard thereof are anti-clear, by China Veterinary Drugs Supervisory Inst., are provided, and before infecting, with broth bouillon, cultivate voluntarily.
1.1.3 supply reagent thing or feed
The Chinese medicine additive 1 of embodiment 1 preparation, sneaks in feed according to the 5-10% of feed gross weight; The Chinese medicine additive 2 of embodiment 2 preparations, sneaks in feed according to the 5-10% of feed gross weight; The feed 1 of embodiment 3 preparation, feeds according to the normal mode of feeding; The feed 2 of embodiment 4 preparation, feeds according to the normal mode of feeding; Penicillin 80-240 ten thousand+10% sulphadiazine parenteral solutions.
1.2 test method
1.2.1 inoculation test
Cultured pig Pasteurella C44-41 meat soup is injected after ear respectively, and infective dose is 12.6 bacterium/kg.w.Infect in latter five days and have 220 pigs to occur swine plague symptom, select 180 ill pigs as experiment pig.
1.2.2 experiment grouping
300 ill piglets are divided into three groups at random, 60 every group, i.e. embodiment group 1, embodiment group 2, embodiment group 3, embodiment group 4 and control group.
1.2.3 test method
The pig that occurs swine plague after infection adopts respectively different methods of treatments, and wherein, embodiment group 1 is used the embodiment of the present invention 1 Chinese medicine additive treatment, Chinese medicine additive 1 is sneaked in feed, according to conventional method, feed, each mixed volume is the 5-10% of feed gross weight, uses continuously three days; Embodiment group 2 is used the embodiment of the present invention 2 Chinese medicine additive treatments, and Chinese medicine additive is sneaked in feed, according to conventional method, feeds, and each mixed volume is the 5-10% of feed gross weight, uses continuously three days; Embodiment group 3 is used the feed 1 of embodiment 3 preparations, according to the normal mode of feeding, feeds; Embodiment group 4 is used the feed 2 of embodiment 4 preparations, according to the normal mode of feeding, feeds; Control group is used penicillin 80-240 ten thousand intramuscular injection, injects the intramuscular injection of water 5-10 milliliter with 10% sulphadiazine 10-20 milliliter simultaneously, and 12 hours once, is used in conjunction 3 days.
1.2.4 observed and recorded
Attack the rear observation of poison and respectively organize clinical symptoms and the pathological change of ill pig, and compare its order of severity, the result for the treatment of of record death toll after infecting, treating after finishing for three days.
2 results
2.1 criterion of therapeutical effect
Cure: ill temperature of pig body, body colour, breathing, appetite are all recovered normally, cough, diarrhoea, oedema phenomenon disappear;
Effective: ill temperature of pig body, body colour, breathing, appetite are progressively recovered normally, and cough, diarrhoea, oedema alleviate;
Invalid: ill pig symptom is not alleviated, and even increases the weight of death.
2.2 observed results are as shown in table 1.
Data from table 1: compare with control group, the feed of the Chinese medicine additive of the embodiment of the present invention 1 and embodiment 2 and embodiment 3 and embodiment 4 has evident in efficacy to the treatment of swine plague, side effect is low, the advantage that treated effect is high, and the result for the treatment of of feed 3 and feed 4 is better than Chinese medicine additive 1 and Chinese medicine additive 2; In long-term observation subsequently, find, the pig that embodiment group 1, embodiment group 2, embodiment group 3 and embodiment group 4 are cured the again incidence of disease is starkly lower than the pig of control group.
2.3 attack the rear symptom of poison and cut open inspection result
Attack after poison, the symptom of ill pig is: more than hyperthermia to 41 ℃, and poor appetite or absolutely useless, expiratory dyspnea, there is purplish-red macula in skin.To infecting rear dead sick pig, dissect, find that whole body mucous membrane, serous coat and hypodermis have blutpunkte, larynx and surrounding tissue hemorrhagic oedema thereof, swollen lymph node, stomach mucosa hemorrhage inflammation, indivedual pig lungs You Ganbian district, and have yellow or grey necrosis region.
Concrete case
Case 1
Certain raiser raises 121 of growing and fattening pigs altogether, and November in 2012,1 growing and fattening pigs sudden onset was dead, and other pigs all have swine plague symptom in various degree, expiratory dyspnea, and neck oedema, there is purple erythema in skin.Dead pig is dissected to the dead pigskin of discovery undertissue blutpunkte, larynx and surrounding tissue hemorrhagic oedema thereof, and gastric bleeding is red and swollen, is diagnosed as swinery and suffers from swine plague.Use the embodiment of the present invention 1 Chinese medicine additive 1 treatment, Chinese medicine additive is sneaked in feed, according to conventional method, feed, each mixed volume is 8% of feed gross weight, use continuously after three days, 163 ill pigs recover normal, and 37 ill pigs continue to feed and add the feed two days of Chinese medicine additive 1, also all recover normal.
Case 2
Certain self-employed worker that raises pigs feeds 10 of growing and fattening pigs, because pigsty is moist, heat, impels germ to spread rapidly, cause more than hyperthermia to 41 ℃ appears in 10 pigs poor appetite or absolutely useless, expiratory dyspnea, there is the symptoms such as purplish-red macula, neck oedema in skin, is diagnosed as swine plague.Use the embodiment of the present invention 2 Chinese medicine additive 2 treatments, Chinese medicine additive is sneaked in feed, according to conventional method, feed, each mixed volume is 6% of feed gross weight, uses continuously after three days, and 10 ill pigs all recover normal.
Case 3
The phenomenon of pig sudden death is found on Zhengzhou, henan pig farm, immediately 103 ill pigs are chosen to isolated rearing, the ill temperature of pig body of the overwhelming majority is elevated to more than 41 ℃, poor appetite or absolutely useless, expiratory dyspnea, there is the symptoms such as purplish-red macula, neck oedema in skin, dead pig is dissected, find that there is blutpunkte in dead pigskin undertissue, larynx and surrounding tissue hemorrhagic oedema thereof, gastric bleeding is red and swollen, is diagnosed as swinery and suffers from swine plague.Use the embodiment of the present invention 4 feeds 2 to feed ill pig according to the routine mode of feeding, use continuously after three days, 100 ill pigs all recover normally, and the ill pig in two continues to use feed 2 to feed one day in addition, also recovers normal.
Case 4
The 60 bull piglets that certain raiser raises, July in 2012, three piglets did not eat food, expiratory dyspnea, dead after one day, there is swine plague symptom in various degree in other piglet subsequently, expiratory dyspnea, there is purple erythema in skin.Dead piglet is dissected and finds that hypodermis has blutpunkte, and larynx hemorrhagic oedema, is diagnosed as swine plague.Use the embodiment of the present invention 3 feeds 1 to feed ill piglet according to the routine mode of feeding, use continuously after three days, 58 ill pigs recover normal, and the ill pig in two continues to use feed 2 to feed two days in addition, also recovers normal.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the feed that is used for the treatment of swine plague, is characterized in that, described feed comprises following raw material: corn, dregs of beans, peanut meal, wheat bran, stone flour, fish meal, tapioca flour, Kelp Powder, vitamin E and Chinese medicine additive.
2. the feed that is used for the treatment of swine plague according to claim 1, it is characterized in that, described feed is comprised of the raw material of following parts by weight: corn 50-80 weight portion, dregs of beans 50-60 weight portion, peanut meal 30-50 weight portion, wheat bran 20-30 weight portion, stone flour 10-30 weight portion, fish meal 10-20 weight portion, tapioca flour 10-30 weight portion, Kelp Powder 20-40 weight portion, vitamin E 5-10 weight portion and Chinese medicine additive 5-18 weight portion.
3. the feed that is used for the treatment of swine plague according to claim 1 and 2, it is characterized in that, described feed is comprised of the raw material of following parts by weight: corn 75 weight portions, dregs of beans 55 weight portions, peanut meal 41 weight portions, wheat bran 26 weight portions, stone flour 19 weight portions, fish meal 15 weight portions, tapioca flour 21 weight portions, Kelp Powder 32 weight portions, vitamin E 7 weight portions and Chinese medicine additive 12 weight portions.
4. according to the feed that is used for the treatment of swine plague described in claim 1-3 any one, it is characterized in that, described Chinese medicine additive comprises following bulk drug: subprostrate sophora, Lasiosphaera fenzlii, the coptis, cape jasmine, the root of large-flowered skullcap, pollen, the dried immature fruit of citron orange, rheum officinale, radix scrophulariae, felwort, akebi, the capsule of weeping forsythia, balloonflower root, the compound of glauber-salt and liquorice, the larva of a silkworm with batrytis, cup chrysanthemum, lepidium seed, perillaseed, fritillaria thunbergii, manyleaf meadowure rhizome and root, betel nut and birthwort.
5. according to the feed that is used for the treatment of swine plague described in claim 1-4 any one, it is characterized in that, described Chinese medicine additive is comprised of the bulk drug of following parts by weight: subprostrate sophora 11～20 weight portions, Lasiosphaera fenzlii 11～25 weight portions, the coptis 11～45 weight portions, cape jasmine 10～16 weight portions, the root of large-flowered skullcap 10～16 weight portions, pollen 10～15 weight portions, the dried immature fruit of citron orange 10～15 weight portions, rheum officinale 10～16 weight portions, radix scrophulariae 10～20 weight portions, felwort 10～15 weight portions, akebi 10～15 weight portions, the capsule of weeping forsythia 10～20 weight portions, balloonflower root 10～15 weight portions, the compound of glauber-salt and liquorice 10～15 weight portions, the larva of a silkworm with batrytis 10～15 weight portions, cup chrysanthemum 10～15 weight portions, lepidium seed 10～15 weight portions, perillaseed 10～20 weight portions, fritillaria thunbergii 10～15 weight portions, manyleaf meadowure rhizome and root 10～15 weight portions, betel nut 10～15 weight portions and birthwort 10～15 weight portions.
6. according to the feed that is used for the treatment of swine plague described in claim 1-5 any one, it is characterized in that, described Chinese medicine additive is comprised of the bulk drug of following parts by weight: subprostrate sophora 15 weight portions, Lasiosphaera fenzlii 18 weight portions, the coptis 29 weight portions, cape jasmine 13 weight portions, the root of large-flowered skullcap 13 weight portions, pollen 12 weight portions, the dried immature fruit of citron orange 12 weight portions, rheum officinale 13 weight portions, radix scrophulariae 15 weight portions, felwort 12 weight portions, akebi 13 weight portions, the capsule of weeping forsythia 15 weight portions, balloonflower root 13 weight portions, the compound of glauber-salt and liquorice 13 weight portions, the larva of a silkworm with batrytis 12 weight portions, cup chrysanthemum 12 weight portions, lepidium seed 13 weight portions, perillaseed 15 weight portions, fritillaria thunbergii 13 weight portions, manyleaf meadowure rhizome and root 12 weight portions, betel nut 12 weight portions and birthwort 13 weight portions.
7. according to the feed that is used for the treatment of swine plague described in claim 1-6 any one, it is characterized in that, described Chinese medicine additive also comprises fibert, corn stigma, rue, rock wind and Radix Glycyrrhizae, described Chinese medicine additive is comprised of the bulk drug of following ratio of weight and number: subprostrate sophora 15～20 weight portions, Lasiosphaera fenzlii 12～25 weight portions, the coptis 20～35 weight portions, cape jasmine 10～16 weight portions, the root of large-flowered skullcap 10～16 weight portions, pollen 10～15 weight portions, the dried immature fruit of citron orange 10～15 weight portions, rheum officinale 10～16 weight portions, radix scrophulariae 11～15 weight portions, felwort 11～15 weight portions, akebi 11～15 weight portions, the capsule of weeping forsythia 11～15 weight portions, balloonflower root 11～15 weight portions, the compound of glauber-salt and liquorice 10～15 weight portions, the larva of a silkworm with batrytis 10～15 weight portions, cup chrysanthemum 11～15 weight portions, lepidium seed 10～15 weight portions, perillaseed 11～18 weight portions, fritillaria thunbergii 11～15 weight portions, manyleaf meadowure rhizome and root 11～15 weight portions, betel nut 11～15 weight portions, birthwort 11～14 weight portions, fibert 11～14 weight portions, corn stigma 10～15 weight portions, rue 11～14 weight portions, rock wind 10～15 weight portions and Radix Glycyrrhizae 15～35 weight portions.
8. according to the feed that is used for the treatment of swine plague described in claim 1-7 any one, it is characterized in that, described Chinese medicine additive is comprised of the bulk drug of following ratio of weight and number: subprostrate sophora 18 weight portions, Lasiosphaera fenzlii 19 weight portions, the coptis 32 weight portions, cape jasmine 13 weight portions, the root of large-flowered skullcap 13 weight portions, pollen 12 weight portions, the dried immature fruit of citron orange 12 weight portions, rheum officinale 13 weight portions, radix scrophulariae 13 weight portions, felwort 13 weight portions, akebi 12 weight portions, the capsule of weeping forsythia 13 weight portions, balloonflower root 13 weight portions, the compound of glauber-salt and liquorice 12 weight portions, the larva of a silkworm with batrytis 12 weight portions, cup chrysanthemum 13 weight portions, lepidium seed 13 weight portions, perillaseed 15 weight portions, fritillaria thunbergii 13 weight portions, manyleaf meadowure rhizome and root 13 weight portions, betel nut 13 weight portions, birthwort 12 weight portions, fibert 13 weight portions, corn stigma 12 weight portions, rue 13 weight portions, rock wind 13 weight portions and Radix Glycyrrhizae 25 weight portions.
9. according to the feed that is used for the treatment of swine plague described in claim 1-8 any one, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials, after mixing, be ground into powder;
Second step, the first step is obtained to powder add in cold water and soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water adding is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water adding and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 order～400 orders, obtain Chinese medicine additive powder.
10. a preparation method for the feed that is used for the treatment of swine plague as described in claim 1-9 any one, is characterized in that, described preparation method comprises the following steps:
Take by ratio of weight and the number of copies all raw materials, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Drop into granulator and granulate, pelleting temperature is 65-80 ℃, makes its gelatinization degree reach 90%;
Drop into disintegrating machine and carry out fragmentation, particle size after cracking is 8-15 order.
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| CN103918947A (en) * | 2014-05-07 | 2014-07-16 | 娄志 | Prophylactic pig feed |
| CN104115993A (en) * | 2014-05-30 | 2014-10-29 | 安徽省正大源饲料集团有限公司 | Animal feed capable of preventing respiratory diseases of animals |
| CN104187152A (en) * | 2014-08-29 | 2014-12-10 | 广西富来康饲料有限公司 | Pig feed and preparation method thereof |
| CN104855738A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Compound feed for pig and preparation method of compound feed |
| CN106212957A (en) * | 2016-08-29 | 2016-12-14 | 广西大学 | A kind of Chinese medicine feed additive preventing and treating pig bacterial disease and preparation method thereof |
| CN106306466A (en) * | 2016-08-18 | 2017-01-11 | 广西丰兄农业开发有限公司 | Feed for treating swine plague and manufacture method thereof |
| CN106472836A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | A kind of feed additive of preventing and treating pig lung plague |
| CN106578374A (en) * | 2016-11-29 | 2017-04-26 | 南宁学院 | Xiang miniature pig feed additive having effect of preventing pig swine plague |
| CN108142683A (en) * | 2016-12-03 | 2018-06-12 | 灵丘县动物疫病预防控制中心 | A kind of swine plague epidemic-prevention fodder and preparation method |
| CN108813186A (en) * | 2018-07-03 | 2018-11-16 | 成都远大牧业发展有限公司 | A kind of pannage formula |
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| CN103918947A (en) * | 2014-05-07 | 2014-07-16 | 娄志 | Prophylactic pig feed |
| CN103918947B (en) * | 2014-05-07 | 2015-07-08 | 娄志 | Prophylactic pig feed |
| CN104115993A (en) * | 2014-05-30 | 2014-10-29 | 安徽省正大源饲料集团有限公司 | Animal feed capable of preventing respiratory diseases of animals |
| CN104187152A (en) * | 2014-08-29 | 2014-12-10 | 广西富来康饲料有限公司 | Pig feed and preparation method thereof |
| CN104855738A (en) * | 2015-06-11 | 2015-08-26 | 山东新希望六和集团有限公司 | Compound feed for pig and preparation method of compound feed |
| CN106306466A (en) * | 2016-08-18 | 2017-01-11 | 广西丰兄农业开发有限公司 | Feed for treating swine plague and manufacture method thereof |
| CN106212957A (en) * | 2016-08-29 | 2016-12-14 | 广西大学 | A kind of Chinese medicine feed additive preventing and treating pig bacterial disease and preparation method thereof |
| CN106472836A (en) * | 2016-09-30 | 2017-03-08 | 安徽华澳生物技术有限公司 | A kind of feed additive of preventing and treating pig lung plague |
| CN106578374A (en) * | 2016-11-29 | 2017-04-26 | 南宁学院 | Xiang miniature pig feed additive having effect of preventing pig swine plague |
| CN108142683A (en) * | 2016-12-03 | 2018-06-12 | 灵丘县动物疫病预防控制中心 | A kind of swine plague epidemic-prevention fodder and preparation method |
| CN108813186A (en) * | 2018-07-03 | 2018-11-16 | 成都远大牧业发展有限公司 | A kind of pannage formula |
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| CN103704513B (en) | 2015-01-07 |
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Effective date of registration: 20201218 Address after: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 266061 Qingdao Industrial Park, Ji Hong Tan Street, Chengyang District, Qingdao, Shandong. Patentee before: SHANDONG NEW HOPE LIUHE GROUP Co.,Ltd. |
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Address after: 253211 Guozhai Forest Farm, Suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province (5F, Qingwo Pioneer Park Office Building, Xiajin Economic Development Zone) Patentee after: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Address before: 253211 Guozhai forest farm, suliuzhuang Town, Xiajin County, Dezhou City, Shandong Province Patentee before: XIAJIN NEW HOPE LIUHE AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. |
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