CN103750060A - Feed for treating pig influenza and preparation method thereof - Google Patents
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- CN103750060A CN103750060A CN201410040063.XA CN201410040063A CN103750060A CN 103750060 A CN103750060 A CN 103750060A CN 201410040063 A CN201410040063 A CN 201410040063A CN 103750060 A CN103750060 A CN 103750060A
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Abstract
The invention discloses a feed for treating pig influenza and a preparation method thereof. The feed comprises the following raw materials: corn, wheat, fermented soybean pulp, whey powder, carrot powder, choline chloride, calcium hydrophosphate, soybean oil, salt and Chinese medicine additives. The feed has the benefits that as the feed contains Chinese medicine additives based on the treatment principles of exterior-interior syndrome relieving, heat clearing, detoxication, gloominess expelling, summer heat removing and dampness expelling, and the additives cooperate and interact with other raw materials in the feed to enhance the organism immunity of pigs, the feed has the advantages of rapid effect, good curative effect, no medicine residue and uneasiness of relapse after the disease is treated when being used for treating pig influenza, and has the health effect on a human body eating pork fed with the feed.
Description
Technical field
The present invention relates to pig feed technical field, particularly a kind of feed that is used for the treatment of swine influenza and preparation method thereof.
Background technology
Swine influenza (English: swine influenza is English to be called for short: be swine flu) that the one of pig is acute, infectiousness respiratory illness.It is characterized by burst, cough, expiratory dyspnea, generates heat and lapses to rapidly.Swine flu is the respiratory disease that pig body internal cause virus causes.Swine flu is caused by influenza A virus (A type influenza virus), conventionally breaks out between pig, and infectiousness is very high but conventionally can not cause death.Belong to the high-incidence season autumn and winter, but can propagate the whole year.One of swine flu is recognized as influenza virus C (C type influenza virus) more, or the subspecies of influenza A virus.This virus can cause Influenza Outbreak in swinery.The little infected pigs of mankind influenza virus under normal circumstances.
This sick incidence of disease is high, and be 2～7 days incubation period, the course of disease about 1 week.Sick pig early stage generates heat suddenly, lassitude, and anorexia or absolutely useless, normal accumbency together, is reluctant activity, expiratory dyspnea, fierce cough, eye nose flows out mucus.If treated not in time in period of disease, easy concurrent bronchitis, pneumonia and pleurisy etc., the case fatality rate of increase pig.Sick temperature of pig body raises and reaches 40 ℃～41.5 ℃, and spirit is depressed, anorexia or do not eat, myalgia, is reluctant to stand, and eye and nose have viscous liquid to flow out, conjunctival congestion, indivedual sick pig expiratory dyspnea, breathe, cough, be abdominal respiration, have sitting position of dog gesture, can hear disease pig whoop at night, the good pig morbidity of indivedual sick pig arthralgia, the especially growth of livestock is more serious.Sow infected in period of pregnancy, and the piglet giving birth to is very heavy in morbidity in 2～5 days postpartum, and some is dead before and after lactation and wean.Cut open inspection visible larynx, tracheae and bronchus and be full of containing alveolate mucus, mucous membrane hyperemia, swelling, time and be mixed with blood, interstitial lung broadening, enlargement of lymph nodes, hyperemia, splenomegaly, gastrointestinal mucosa has catarrh hemorrhagic inflammation, and splanchnocoel, cavum pericardiale are accumulated the liquid of cellulose-containing mass.The pig of each age, sex and kind has neurological susceptibility to this virus.This disease popular has obvious seasonality, and weather easily occurs changeable autumn end, early spring and cold winter.This disease is propagated rapidly, is often region popular or be very popular.This sick incidence of disease is high, the death rate low (4%～10%).Sick pig and be the infection sources of swine flu with malicious pig, pig band poison 6～8 weeks after ill recovery from illness.
Swine influenza is caused by swine influenza virus, many sudden onset, and body temperature 40-41 ℃, expiratory dyspnea, cough, eye nose flows out slurry property liquid.At present treatment application antibiotic, the medicine such as antiviral, drug residue is large, easily produces drug resistance, and the state of an illness easily repeatedly, has certain adverse effect for body health after edible this type of pork of people.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of feed that is used for the treatment of swine influenza and preparation method thereof, in feed, contain Chinese medicine additive, can overcome the defect of prior art Chinese and Western medicine, to suffering from the treatment strengthening vital QI to eliminate pathogenic factors of pig of swine influenza, cure rate is high, has no side effect, evident in efficacy, have no drug resistance, drug residue free, is difficult for the advantage recurring.
In order to realize foregoing invention object, the invention provides the feed that is used for the treatment of swine influenza, described feed comprises following raw material: corn, wheat, fermented bean dregs, whey powder, carrot meal, Choline Chloride, calcium monohydrogen phosphate, soybean oil, salt and Chinese medicine additive.
Described feed is comprised of the raw material of following parts by weight: corn 30-50 weight portion, wheat 30-40 weight portion, fermented bean dregs 20-40 weight portion, whey powder 10-20 weight portion, carrot meal 10-20 weight portion, Choline Chloride 5-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 1-5 weight portion and Chinese medicine additive 3-7 weight portion.
Described feed is comprised of the raw material of following parts by weight: corn 35-45 weight portion, wheat 33-38 weight portion, fermented bean dregs 25-35 weight portion, whey powder 12-18 weight portion, carrot meal 12-18 weight portion, Choline Chloride 6-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 2-5 weight portion and Chinese medicine additive 4-6 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Poria cocos, hare's-lettuce, the capsule of weeping forsythia, the red sage root, polyporus lucidus, caecum grass, folium isatidis, champion wood fern rhizome, mulberry leaf, root of Compact Incarvillea, Chinese alpine rush and Radix Glycyrrhizae.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion and Radix Glycyrrhizae 10-20 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion and Radix Glycyrrhizae 13-17 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portions, Radix Codonopsis 17 weight portions, Poria cocos 20 weight portions, hare's-lettuce 13 weight portions, the capsule of weeping forsythia 17 weight portions, the red sage root 15 weight portions, polyporus lucidus 13 weight portions, caecum grass 15 weight portions, folium isatidis 20 weight portions, champion wood fern rhizome 15 weight portions, mulberry leaf 15 weight portions, root of Compact Incarvillea 13 weight portions, Chinese alpine rush 18 weight portions and Radix Glycyrrhizae 15 weight portions.
Described feed also comprises ginger, Kiwi berry, the bletilla striata, schizonepeta, Sha Peng and dried orange peel, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, ginger 10-20 weight portion, Kiwi berry 10-15 weight portion, bletilla striata 12-20 weight portion, schizonepeta 15-20 weight portion, husky fluffy 10-15 weight portion and dried orange peel 10-20 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion, Radix Glycyrrhizae 13-17 weight portion, ginger 13-16 weight portion, Kiwi berry 12-15 weight portion, bletilla striata 14-17 weight portion, schizonepeta 15-17 weight portion, husky fluffy 12-15 weight portion and dried orange peel 13-17 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portions, Radix Codonopsis 17 weight portions, Poria cocos 20 weight portions, hare's-lettuce 13 weight portions, the capsule of weeping forsythia 17 weight portions, the red sage root 15 weight portions, polyporus lucidus 13 weight portions, caecum grass 15 weight portions, folium isatidis 20 weight portions, champion wood fern rhizome 15 weight portions, mulberry leaf 15 weight portions, root of Compact Incarvillea 13 weight portions, Chinese alpine rush 18 weight portions, Radix Glycyrrhizae 15 weight portions, ginger 15 weight portions, Kiwi berry 13 weight portions, the bletilla striata 16 weight portions, schizonepeta 16 weight portions, husky fluffy 13 weight portions and dried orange peel 16 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 2～4 hours, and the amount of the water adding and the mass ratio of mixture are 6～9:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, the dregs of a decoction after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 2～4 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 6～10:1, decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains the clear cream of mixture, and under 60 ℃ of conditions, the relative density of clear cream is 1.10～1.20;
The 5th step, in the clear cream of mixture, adding determining alcohol is 95% ethanol, obtains containing the clear cream of alcohol, the ethanol adding is 2～3:1 with the mass ratio of clear cream;
The 6th step, will, containing at room temperature standing 12～24h of the clear cream of alcohol, get supernatant, and clear cream residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, and is ground into powder, obtains pulvis.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the feed that is used for the treatment of swine influenza, described preparation method comprises the following steps:
Take by ratio of weight and the number of copies corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Raw material and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive after pulverizing are all dropped into mixer, mix, incorporation time is 3 minutes;
Drop into granulator and granulate, pelleting temperature is 75-85 ℃.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contain take relieving exterior-interior syndrome, clearing heat and detoxicating, a surname Xie Yangyu, eliminate summer heat and remove dampness as the Chinese medicine additive of principle of reatment, cooperatively interact with other feedstuffs, acting in conjunction, can strengthen pig body resistance, treatment swine influenza have rapid-action, good effect, drug residue free, be difficult for after being ill the advantage of recurrence, and also can play certain health-care effect to body after edible this type of pork of people.
The specific embodiment
Chinese veterinarian's theory is thought, swine influenza is to defend table because the outer heresy of the six external factors which cause diseases causes the heresy of epidemic disease poison to invade pig body, so that disharmony between ying and wei, lung is defended and is lost admittedly, the present invention is with relieving exterior-interior syndrome, clearing heat and detoxicating, a surname Xie Yangyu, eliminate summer heat and remove dampness as principle of reatment, a kind of feed that is used for the treatment of swine influenza is provided, and the Chinese medicine additive in feed comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Poria cocos, hare's-lettuce, the capsule of weeping forsythia, the red sage root, polyporus lucidus, caecum grass, folium isatidis, champion wood fern rhizome, mulberry leaf, root of Compact Incarvillea, Chinese alpine rush and Radix Glycyrrhizae.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Admittedly de-for invigorating qi for consolidating superficies, arrest sweating, to hold in the palm sore myogenic, inducing diuresis for removing edema effect.< < book on Chinese herbal medicine meets former > > to carry: all void of Radix Astragali energy tonifying five zang organs, control arteries and veins string spontaneous perspiration, and rush down yin fire, remove lung heat, losslessly send out, there is sweat to stop.Be used for the treatment of the deficiency of vital energy weak, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, and exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts and does not hold back for a long time, and the deficiency of blood is sallow, and interior heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The bowl spares of astragalus root benefit gas, raw by solid table holder sore.The Radix Astragali is the good medicine of promoting resistance and defence disease.
Radix Codonopsis: property is flat, sweet, the micro-acid of taste.Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.The just > > of < < book on Chinese herbal medicine carries: Radix Codonopsis power energy tonifying spleen nourishing the stomach, and moistening lung is promoted the production of body fluid, gas in tendon fortune, this is very mutually not far away with ginseng.Its outstanding valuable person, invigorating the spleen fortune and not dry, grows stomach-Yin and wet, and moistening lung and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Astragali tonifying Qi, can rise enriching spleen-QI, can admittedly show by beneficial lung again.Radix Codonopsis tonifying Qi, can only invigorating the spleen tonifying Qi, and without the power of solid table, but Radix Codonopsis can also nourishing generate fluid, and the Radix Astragali is without the effect of promoting the production of body fluid, the double energy of Radix Astragali Li Shui, and Radix Codonopsis is without Li Shui effect.This two tastes medicine share can tonifying middle-Jiao and Qi, improves resistance.
Poria cocos: sweet, light, flat.The thoughts of returning home, lung, spleen, kidney channel.Function clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.For oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, and have loose bowels in loose stool, confused and worried, palpitation with fear insomnia.Eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Control difficult urination, oedema turgor, phlegm and retained fluid is coughed contrary, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.< < herbal classic > > carries it: " the contrary gas of the main chest side of body, sorrow is angerd frightened heresy and is probably throbbed with fear, knot pain under the heart, fever and chills dysphoria, coughs contraryly, and mouthful burnt tongue is dry, diuresis." < < do not record > >: " and only quench one's thirst, like to sleep, large abdomen, drenches drop, phlegm water in diaphragm, and oedema is drenched knot.Open chest internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, beneficial strength, during guarantor god keeps." < < property of medicine opinion > >: " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease phlegm is stopped up.Control pediatric epilepsy scared, trusted subordinate's turgor, married woman's heat is drenched.”
Hare's-lettuce: bitter; Cold in nature.Function cures mainly: clearing heat and detoxicating.Main jaundice; Gastritis; Dysentery; Cough with lung heat; Intestines produce swollen; Orchitis; Parent's sore; Carbuncle is swollen; Impetigo.
The capsule of weeping forsythia: bitter, cold nature, enters the heart, liver, courage, small intestinl channel, have clearing heat and detoxicatingly, the effect of dispersing swelling and dissipating binds, for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of, warm joining the army, high hot polydipsia, coma is sent out spot, and heat is drenched the treatment of the cards such as renal shutdown, and shigella dysenteriae, staphylococcus aureus are had to very strong inhibitory action.
The red sage root: hardship, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect.. < < detailed outline > > carries: the red sage root, press the sensible opinion of < < married woman > > cloud, Siwu Tang is controlled gynecopathy, pay no attention to antenatal postpartum, how many through water, all can be general, the only taste red sage root is loose, cures mainly identical with it.Lid the red sage root can break place blood, mend new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.
Polyporus lucidus: sweet, flat.Function cures mainly: control consumptive disease, cough, asthma, insomnia, indigestion.
Caecum grass: taste is sweet; Micro-hardship; Cool in nature.Function cures mainly: heat-clearing; Removing toxic substances; Dampness removing; Invigorating the spleen.Main influenza; Abscess of throat; Icterohepatitis; Summer-heat and damp is vomited and diarrhoea; Enteritis; Dysentery; Acute appendicitis; Infantile malnutrition; The deficiency of blood is yellow swollen; Hemorrhoid; Snake bite and insect sting.
Folium isatidis: be mainly used in heat poison and send out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.This medicine extensive use clinically in recent years, controls above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, both can be applied to prevention by single, can coordinate again radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, the dried rhizome of rehmannia etc., can removing summer-heat gas divide, seek the heat poison dividing, availablely control various encephalitis, and comparatively suitable with partial heat type.< < detailed outline > >: " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." the positive > > of < < book on Chinese herbal medicine: " and control the hot poison of pestilence and go mad, wind-heat macula, large carbuncle swells and ache, relieving thirst and restlessness, only nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.All with the heat malicious person that holds concurrently, all should blue leaf smash juice and use it.”
Champion wood fern rhizome: hardship, flat, nontoxic.Return lung; Large intestine channel.Function cures mainly: clearing heat and detoxicating; Relieving asthma; Arresting bleeding and treating cutaneous pyogenic infection; Expelling parasite.Main flu; Hot eyes is caught pain; Asthma; Have blood in stool; Sore festers; Scald; Hookworm disease.
Mulberry leaf: sweet, bitter, cold.Return lung, Liver Channel.Function cures mainly: dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clears liver and improve vision.For anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes is dim-sighted.
Root of Compact Incarvillea: bitter; Micro-sweet; Property is put down.Return liver, spleen, lung, stomach four warps.Function cures mainly: heat-clearing; Fresh poison; Eliminating dampness; Help digestion.Main heating; Jaundice; Tympanitis; Indigestion; Stomachache; Abdominal distention constipation.
Chinese alpine rush: sweet, light, flat.Function cures mainly: heat clearing and inflammation relieving, flat liver improving eyesight, hemostasis.Cure mainly flu, hepatitis, infantile pneumonia, mastitis, urticaria, puerperal fever, stomachache, traumatism and bleeding.
Radix Glycyrrhizae: property is flat, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Chinese medicine additive of the present invention also comprises: ginger, Kiwi berry, the bletilla striata, schizonepeta, Sha Peng and dried orange peel.
Ginger: warm in nature, its distinctive " gingerol " can stimulating gastrointestinal mucous membrane, make intestines and stomach hyperemia, digestion power strengthens, and can effectively treat the abdominal distension of eating cold and cool food and too much causing, stomachache, diarrhoea, vomiting etc.Ate after ginger, people has the sensation of health heating, and this is because it can distend the blood vessels, and blood circulation is accelerated, and impels pore with it to open, and so not only the unnecessary torrid zone can be walked, and also the germ in body, cold air is together taken out of simultaneously.When health, eaten cold and cool thing, be subject to drench with rain or in air-conditioned room, stayed long afterwards, eaten ginger and just can eliminate in time because of the cold various discomforts that remake of human body.For the pungent stomachic tonic of armaticity, there are the effects such as warm, excited, sweating, preventing or arresting vomiting, removing toxic substances, warm lung cough-relieving, especially for fish crab poison, the drug poisoning such as the tuber of pinellia, rhizoma arisaematis have detoxication.Be applicable to catch cold, headache, phlegm and retained fluid, cough, gastrofrigid vomiting; Suffering, after ice and snow, wet, the cold invasion and attack of water, suddenly to drink it with ginger decoction, can promote blood, disperse cold-evil.
Kiwi berry: sweet; Acid; Cold.Return kidney; Stomach; Courage; The spleen channel.Function cures mainly: antipyretic; Quench the thirst; Stomach invigorating; Treating stranguria.Main dysphoria with smothery sensation; Quench one's thirst; Lung heat dry cough; Indigestion; Jaundice with damp-heat pathogen; Urolithiasis; Hemorrhoid.
The bletilla striata: bitter, sweet, puckery, be slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.For hemoptysis, spit blood, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.< < Sheng Nong's herbal classic > >: " main carbuncle swells, dislikes sore, loses subcutaneous ulcer; the dead flesh of impairment of yin, perverse trend in stomach " < < Compendium of Materia Medica > >: " smell (root) is bitter, flat, nontoxic.
Schizonepeta: taste is pungent, slightly warm in nature, enters lung, Liver Channel, has inducing sweat and dispelling exogenous evils, declares malicious promoting eruption, and the effect of blood hemostasis, and no matter the fever and headache due to the wind-heat that is mainly used in catching cold, have sweat lossless, all can apply; The headache of attacking in wind-heat is dizzy, and rash goes out not saturating; Postpartum anemic fainting apoplexy, the cards such as discharging fresh blood stool.
Sha Peng: sweet, cool.Function cures mainly: deliver antipyretic.Cure mainly cat fever, ephritis.
Dried orange peel: regulating the flow of Qi and the middle Jiao, eliminating dampness and eliminating phlegm, sharp water defaecation.Cure mainly incoordination between the spleen and the stomach, abdominal distention, do not feel like eating, vomiting hiccup; Phlegm-damp obstructing lung, coughing with a lot of sputum, chest diaphragm is full vexed, vertigo; Oedema, difficult urination, constipation; Acute mastitis sore tinea, middle fish crab poison, wine poison.For diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, for lung qi gather around stagnant, chest diaphragm ruffian full and the disease such as the taste stagnation of the circulation of vital energy, abdominal fullness and distention.Temperature eliminating dampness and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Be good at again eliminating dampness and eliminating phlegmly, for controlling wet phlegm, stop up the conventional key medicines of lung, the many coughs of phlegm, every with the tuber of pinellia, Poria cocos with use.For insufficiency of the spleen diet reduce, indigestion, and the disease such as n and V, eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizing, indigestion, stool diarrhea, the fit applications such as normal and ginseng, the bighead atractylodes rhizome, Poria cocos.Can invigorating the spleen because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up the swollen effect of doing of holding back.In addition, orange peel again can with in, can control stomach Qi rising, n and V.
Embodiment 1 feed 1
The embodiment of the present invention provides a kind of feed that is used for the treatment of swine influenza, the raw material of following parts by weight, consists of: corn 32 weight portions, wheat 40 weight portions, fermented bean dregs 37 weight portions, whey powder 12 weight portions, carrot meal 20 weight portions, Choline Chloride 5 weight portions, calcium monohydrogen phosphate 3 weight portions, soybean oil 3 weight portions, salt 2 weight portions and Chinese medicine additive 4 weight portions.
Wherein, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portions, Radix Codonopsis 17 weight portions, Poria cocos 20 weight portions, hare's-lettuce 13 weight portions, the capsule of weeping forsythia 17 weight portions, the red sage root 15 weight portions, polyporus lucidus 13 weight portions, caecum grass 15 weight portions, folium isatidis 20 weight portions, champion wood fern rhizome 15 weight portions, mulberry leaf 15 weight portions, root of Compact Incarvillea 13 weight portions, Chinese alpine rush 18 weight portions and Radix Glycyrrhizae 15 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 4 hours, and the amount of the water adding and the mass ratio of mixture are 8:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, the dregs of a decoction after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 4 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 10:1, decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains the clear cream of mixture, and under 60 ℃ of conditions, the relative density of clear cream is 1.20;
The 5th step, in the clear cream of mixture, adding determining alcohol is 95% ethanol, obtains containing the clear cream of alcohol, the ethanol adding is 3:1 with the mass ratio of clear cream;
The 6th step, will, containing at room temperature standing 20h of the clear cream of alcohol, get supernatant, and clear cream residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, and is ground into powder, obtains pulvis.
Embodiment of the present invention Chinese medicine additive can be used separately, is about to Chinese medicine additive soluble in water, each 5-8g Chinese medicine additive, and gavage every day for 1-3 time.
The preparation method of the feed of the embodiment of the present invention comprises the following steps:
Take by ratio of weight and the number of copies corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate, drop into pulverizer and pulverize, grinding particle size is 30 orders;
Raw material and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive after pulverizing are all dropped into mixer, mix, incorporation time is 3 minutes;
Drop into granulator and granulate, pelleting temperature is 80 ℃.
Embodiment 2 feeds 2
The embodiment of the present invention provides a kind of feed that is used for the treatment of swine influenza, and described feed is comprised of the raw material of following parts by weight: corn 41 weight portions, wheat 35 weight portions, fermented bean dregs 30 weight portions, whey powder 15 weight portions, carrot meal 15 weight portions, Choline Chloride 7 weight portions, calcium monohydrogen phosphate 4 weight portions, soybean oil 4 weight portions, salt 3 weight portions and Chinese medicine additive 5 weight portions.
Wherein, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 18 weight portions, Radix Codonopsis 17 weight portions, Poria cocos 20 weight portions, hare's-lettuce 13 weight portions, the capsule of weeping forsythia 17 weight portions, the red sage root 15 weight portions, polyporus lucidus 13 weight portions, caecum grass 15 weight portions, folium isatidis 20 weight portions, champion wood fern rhizome 15 weight portions, mulberry leaf 15 weight portions, root of Compact Incarvillea 13 weight portions, Chinese alpine rush 18 weight portions, Radix Glycyrrhizae 15 weight portions, ginger 15 weight portions, Kiwi berry 13 weight portions, the bletilla striata 16 weight portions, schizonepeta 16 weight portions, Sha Peng 13 weight portions and dried orange peel 16 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 3 hours, and the amount of the water adding and the mass ratio of mixture are 7:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, the dregs of a decoction after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 3 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 8:1, and decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains the clear cream of mixture, and under 60 ℃ of conditions, the relative density of clear cream is 1.10;
The 5th step, in the clear cream of mixture, adding determining alcohol is 95% ethanol, obtains containing the clear cream of alcohol, the ethanol adding is 3:1 with the mass ratio of clear cream;
The 6th step, will, containing at room temperature standing 18h of the clear cream of alcohol, get supernatant, and clear cream residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, and is ground into powder, obtains pulvis.
Embodiment of the present invention Chinese medicine additive can be used separately, is about to Chinese medicine additive soluble in water, each 5-8g Chinese medicine additive, and gavage every day for 1-3 time.
The preparation method of the feed of the embodiment of the present invention comprises the following steps:
Take by ratio of weight and the number of copies corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate, drop into pulverizer and pulverize, grinding particle size is 40 orders;
Raw material and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive after pulverizing are all dropped into mixer, mix, incorporation time is 3 minutes;
Drop into granulator and granulate, pelleting temperature is 85 ℃.
Challenge test
1, acute toxicity test
According to acute toxicity test, require to carry out prerun, find that tested medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get 40 of above-mentioned mouse, fasting be can't help water after 12 hours, by body weight, be divided at random administration group and water control group, every group 20, administration group is given the liquid 0.4ml/10g of the crude drug amount 2.4g/ml concentration of the Chinese medicine additive of preparing containing embodiment 1, gavage one day 2 times, makes dosage in a day reach symphysis dose 192.0g/kg, and water control group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, all Continuous Observations seven days, the toxic reaction that record may occur and death condition, after administration, mouse outward appearance hair color light, behavioral activity is normal, without abnormal pathologic neural reflex, occur, in seven days, well, other Novel presentation is seen at end in feed, and changes of weight is no significant difference and none animal dead compared with water control group, visually observe the main organs such as the heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, result is as identical in the test result of embodiment 1 Chinese medicine additive.
2, long term toxicity test
The Chinese medicine additive of the embodiment of the present invention 1 to mouse by 10.78,20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of the Chinese medicine additive of the embodiment of the present invention 1 to mouse, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.The Chinese medicine additive that the embodiment of the present invention 1 is described to mouse long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, result is as identical in the test result of embodiment 1 Chinese medicine additive.
Clinical testing
(1) animal used as test
In by the end of November, 2011, certain pig farm is found the pig anorexia of nearly 20 left and right or is given up absolutely, avoirdupoisly sleeping be reluctant activity, expiratory dyspnea together, eye nose flows out mucus, after one week, find that pig farm has 400 pigs nearly all to occur above-mentioned symptom, ill temperature of pig body is increased to more than 40 ℃, conjunctival congestion, the higher pig state of an illness of body weight is existing to seriously.Ill pig of random choose is cutd open inspection and finds, ill pig larynx, tracheae and bronchus are full of containing alveolate mucus, mucous membrane hyperemia, and swelling, enlargement of lymph nodes, hyperemia, splanchnocoel, cavum pericardiale are accumulated the liquid of cellulose-containing mass.Be diagnosed as swinery and suffer from influenza, choose 180 ill pigs as supplying examination animal.
(2) test method
By 180, for examination animal, adopt random device to be divided into three groups, every group of 60 ill pigs, adopt respectively the feed (embodiment group 1) of the embodiment of the present invention 1, feed (embodiment group 2) and the Panadinum parenteral solution (control group) of embodiment 2 to treat.Wherein, the feed of embodiment group 1 and 2 is fed according to the routine mode of feeding; The Panadinum parenteral solution 4-6ml intramuscular injection of control group, once a day, the conventional feed of feeding.Test period is 3-5 days.
(3) criterion of therapeutical effect
Recovery from illness: spirit, body temperature and appetite are all recovered normally, respiratory symptom disappears, and eye nose flows out without mucus, is judged to be recovery from illness;
Effective: spirit, body temperature and appetite are recovered normally substantially, and respiratory symptom is clearly better, eye nose mucus flows out symptom and alleviates, and is judged to be effectively;
Invalid: after medication, symptom does not alleviate even and increases the weight of.
Wherein, recovery from illness and effective percentage sum are counted efficient.
(4) treatment results
Result for the treatment of is as shown in table 1, and from result for the treatment of, adopting feed of the present invention is more than 95% to the treated effect of swine influenza, higher than control group.
The table 1 result for the treatment of table of comparisons
From the data of table 1, can find out: compared with control group, use the feed treatment swine influenza of the embodiment of the present invention 1 and embodiment 2 have advantages of evident in efficacy, cure rate is high.Select 5 of pigs of recovery from illness pig sneaked in ill pigsty after label respectively as experimental subjects for every group, according to the normal mode of feeding, feed, through bimestrial observation, find embodiment group 1 and embodiment group 2 pigs again the incidence of disease be starkly lower than the pig of control group.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the feed that is used for the treatment of swine influenza, is characterized in that, described feed comprises following raw material: corn, wheat, fermented bean dregs, whey powder, carrot meal, Choline Chloride, calcium monohydrogen phosphate, soybean oil, salt and Chinese medicine additive.
2. the feed that is used for the treatment of swine influenza according to claim 1, it is characterized in that, described feed is comprised of the raw material of following parts by weight: corn 30-50 weight portion, wheat 30-40 weight portion, fermented bean dregs 20-40 weight portion, whey powder 10-20 weight portion, carrot meal 10-20 weight portion, Choline Chloride 5-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 1-5 weight portion and Chinese medicine additive 3-7 weight portion.
3. the feed that is used for the treatment of swine influenza according to claim 1 and 2, it is characterized in that, described feed is comprised of the raw material of following parts by weight: corn 35-45 weight portion, wheat 33-38 weight portion, fermented bean dregs 25-35 weight portion, whey powder 12-18 weight portion, carrot meal 12-18 weight portion, Choline Chloride 6-8 weight portion, calcium monohydrogen phosphate 3-5 weight portion, soybean oil 3-5 weight portion, salt 2-5 weight portion and Chinese medicine additive 4-6 weight portion.
4. according to the feed that is used for the treatment of swine influenza described in claim 1-3 any one, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Poria cocos, hare's-lettuce, the capsule of weeping forsythia, the red sage root, polyporus lucidus, caecum grass, folium isatidis, champion wood fern rhizome, mulberry leaf, root of Compact Incarvillea, Chinese alpine rush and Radix Glycyrrhizae.
5. according to the feed that is used for the treatment of swine influenza described in claim 1-4 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion and Radix Glycyrrhizae 10-20 weight portion.
6. according to the feed that is used for the treatment of swine influenza described in claim 1-5 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion and Radix Glycyrrhizae 13-17 weight portion.
7. according to the feed that is used for the treatment of swine influenza described in claim 1-6 any one, it is characterized in that, described feed also comprises ginger, Kiwi berry, the bletilla striata, schizonepeta, Sha Peng and dried orange peel, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Poria cocos 15-25 weight portion, hare's-lettuce 10-15 weight portion, capsule of weeping forsythia 10-20 weight portion, red sage root 10-20 weight portion, polyporus lucidus 10-14 weight portion, caecum grass 10-20 weight portion, folium isatidis 15-25 weight portion, champion wood fern rhizome 10-20 weight portion, mulberry leaf 10-20 weight portion, root of Compact Incarvillea 10-20 weight portion, Chinese alpine rush 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, ginger 10-20 weight portion, Kiwi berry 10-15 weight portion, bletilla striata 12-20 weight portion, schizonepeta 15-20 weight portion, husky fluffy 10-15 weight portion and dried orange peel 10-20 weight portion.
8. according to the feed that is used for the treatment of swine influenza described in claim 1-7 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-20 weight portion, Radix Codonopsis 15-20 weight portion, Poria cocos 18-22 weight portion, hare's-lettuce 12-15 weight portion, capsule of weeping forsythia 15-20 weight portion, red sage root 12-17 weight portion, polyporus lucidus 12-14 weight portion, caecum grass 12-17 weight portion, folium isatidis 18-22 weight portion, champion wood fern rhizome 12-17 weight portion, mulberry leaf 12-18 weight portion, root of Compact Incarvillea 12-15 weight portion, Chinese alpine rush 14-20 weight portion, Radix Glycyrrhizae 13-17 weight portion, ginger 13-16 weight portion, Kiwi berry 12-15 weight portion, bletilla striata 14-17 weight portion, schizonepeta 15-17 weight portion, husky fluffy 12-15 weight portion and dried orange peel 13-17 weight portion.
9. according to the feed that is used for the treatment of swine influenza described in claim 1-8 any one, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, takes all bulk drugs according to parts by weight, drops into pulverizer and carries out pulverization process, obtains corase meal, obtains mixture;
Second step, the mixture that the first step is obtained carries out decocting for the first time and boils processing, and decocting time is 2～4 hours, and the amount of the water adding and the mass ratio of mixture are 6～9:1, and decoction liquor is filtered, and obtains decoction liquor for the first time;
The 3rd step, the dregs of a decoction after the decoction liquor for the first time that second step is obtained is filtered decoct processing for the second time, and decocting time is 2～4 hours, and the mass ratio of the mixture that the amount of the water adding and the first step obtain is 6～10:1, decoction liquor is filtered, and obtains decoction liquor for the second time;
The 4th step, merges decoction liquor and for the second time decoction liquor for the first time, concentrated, obtains the clear cream of mixture, and under 60 ℃ of conditions, the relative density of clear cream is 1.10～1.20;
The 5th step, in the clear cream of mixture, adding determining alcohol is 95% ethanol, obtains containing the clear cream of alcohol, the ethanol adding is 2～3:1 with the mass ratio of clear cream;
The 6th step, will, containing at room temperature standing 12～24h of the clear cream of alcohol, get supernatant, and clear cream residue is carried out to filtration treatment, and the liquid of filtration and supernatant merge, and reduced pressure concentration is also dry, obtains and gets dry extract, and is ground into powder, obtains pulvis.
10. a preparation method for the feed that is used for the treatment of swine influenza as described in claim 1-9 any one, is characterized in that, described preparation method comprises the following steps:
Take by ratio of weight and the number of copies corn, wheat, fermented bean dregs, Choline Chloride and calcium monohydrogen phosphate, drop into pulverizer and pulverize, grinding particle size is 25-40 order;
Raw material and whey powder, carrot meal, soybean oil, salt and Chinese medicine additive after pulverizing are all dropped into mixer, mix, incorporation time is 3 minutes;
Drop into granulator and granulate, pelleting temperature is 75-85 ℃.
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| CN104083691A (en) * | 2014-05-28 | 2014-10-08 | 青岛华仁技术孵化器有限公司 | Medicine feed additive for controlling pig influenza |
| CN104082538A (en) * | 2014-05-28 | 2014-10-08 | 青岛华仁技术孵化器有限公司 | Feed for controlling pig influenza |
| CN104115993A (en) * | 2014-05-30 | 2014-10-29 | 安徽省正大源饲料集团有限公司 | Animal feed capable of preventing respiratory diseases of animals |
| CN104366018A (en) * | 2014-12-10 | 2015-02-25 | 叶红 | Feed for preventing swine influenza and method for manufacturing feed |
| CN105851595A (en) * | 2016-05-31 | 2016-08-17 | 李加义 | Piglet feed additive |
| CN105995094A (en) * | 2016-05-31 | 2016-10-12 | 李加义 | Feed additive for medium pigs |
| CN107136012A (en) * | 2017-05-19 | 2017-09-08 | 巍山县瑞丰牧业有限责任公司 | Feeding live pig management method |
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