CN104082538A - Feed for controlling pig influenza - Google Patents
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- CN104082538A CN104082538A CN201410230988.0A CN201410230988A CN104082538A CN 104082538 A CN104082538 A CN 104082538A CN 201410230988 A CN201410230988 A CN 201410230988A CN 104082538 A CN104082538 A CN 104082538A
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
Provided feed for controlling pig influenza comprises the raw materials: corn, soybean meal, edible salt, fish meal, soybean oil, zinc methionine, copper lysine, tryptophan, vitamin A, vitamin E, ethoxyquin and a traditional Chinese medicine composition feed additive for controlling pig influenza. The traditional Chinese medicine composition feed additive is abundant in drug source, relatively low in residual toxicity or free of residual toxicity, small in side effect and not easy for generating of drug resistance, is capable of regulating body immune function, inhibiting virus replication and improving disease symptoms, and has substantial effect on controlling pig influenza.
Description
Technical field
The present invention relates to field of feed, relate in particular to a kind of for preventing and treating the feed of swine influenza.
Background technology
Swine flu claims again swine influenza, that the one that caused by the swine influenza virus of the A of orthomyxovirus section type Influenza Virus is acute, hot, height contact respiratory infectious disease, clinical taking burst, high heat, cough, expiratory dyspnea, outbreak repeatedly, the incidence of disease is high, the death rate is low as feature.
Swine flu is large scale of pig farm field ubiquity and is difficult to the swinery property the sent out disease of eradicating, and not only can directly cause affected pig death, and affected pig production performance is declined; recover slowly; postpone listing, directly affect the quality of swinery health status and pig, very harmful to pig industry.More significant is, swine influenza virus is that the primary of " porcine respiratory disease syndrome " is caused a disease former, because having high special parent preferendum to airway epithelial, swine influenza virus make airway epithelial tube wall impaired, cause Actinobacillus pleuropneumoniae, haemophilus, Pasteurella, pig 2 type streptococcus, PRCV (PRCV), secondary or the mixed infection of other respiratory tract bacteriums such as pig breeding and disordered breathing syndrome virus (PRRSV) and Respirovirus, make epidemic situation more complicated, aggravation, the death rate increases, the economic loss causing thus cannot be estimated especially.
At present, swine flu is without specific drug, traditional Western medicine curative effect of medication of preventing and treating swine flu is general, this type of medicine is taking influenza virus stromatin as action target spot, stop virus uncoating by blocking-up M2 ion channel, viral RNA can not be discharged in cytoplasm, copying in early days of virus is suppressed, thereby play its resisiting influenza virus effect, but swine influenza virus strain can develop immunity to drugs to this class medicine of long-term use.
Chinese herbal medicine, as natural products, has medicine source abundant, and residual hazard is lower or without residual hazard, side effect is little, is difficult for producing the advantages such as drug resistance; Can regulate body's immunity, suppress virus replication, improve illness symptom, on control disease of viral infection, be widely used simultaneously.Therefore, application herbal control swine flu, prospect is very wide, and the present invention is exactly that a kind of term proposing is is on this basis prevented and treated the Chinese medicine composition feed addictive of swine flu and adopted the feed of this feed addictive, adopts this Chinese medicine composition to realize the control of swine influenza.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing and treating the Chinese medicine composition feed addictive of swine influenza and adopting the feed of this feed addictive, it is abundant that this Chinese medicine composition has medicine source, residual hazard is lower or without residual hazard, side effect is little, be difficult for producing resistance, it can regulate body's immunity, suppresses virus replication, improve illness symptom, there is significant effect preventing and treating aspect swine influenza.
For solving the problems of the technologies described above, the invention provides a kind ofly for preventing and treating the Chinese medicine composition feed addictive of swine influenza, its bulk drug comprises dandelion, the coptis, Chinese ephedra, cassia twig, Morinda officinalis, the bighead atractylodes rhizome, Companumoea root, Gorgon fruit, the fruit of glossy privet, parasitic loranthus, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, leaf of negundo chastetree, the fruit of Chinese magnoliavine, kuh-seng, Radix Angelicae Sinensis, subprostrate sophora, pyrola, gynostemma pentaphylla and radix bupleuri.
Wherein, the weight of described each bulk drug is respectively dandelion 22g～32g, coptis 50g～60g, Chinese ephedra 31g～41g, cassia twig 25g～35g, Morinda officinalis 30g～40g, bighead atractylodes rhizome 27g～37g, Companumoea root 30g～40g, Gorgon fruit 25g～35g, fruit of glossy privet 31g～41g, parasitic loranthus 23g～33g, Kaempferia galanga 19g～29g, Rose Mallow Root 20g～30g, milfoil 17g～27g, suchow mosla herb 26g～36g, horse sour jujube 25g～35g, saururus chinensis 19g～29g, leaf of negundo chastetree 20g～30g, fruit of Chinese magnoliavine 29g～39g, kuh-seng 23g～33g, Radix Angelicae Sinensis 30g～40g, subprostrate sophora 25g～35g, pyrola 28g～38g, gynostemma pentaphylla 30g～40g and radix bupleuri 25g～35g.
Wherein, the weight of described each bulk drug is respectively dandelion 25g～29g, coptis 53g～57g, Chinese ephedra 34g～38g, cassia twig 28g～32g, Morinda officinalis 33g～37g, bighead atractylodes rhizome 30g～34g, Companumoea root 33g～37g, Gorgon fruit 28g～32g, fruit of glossy privet 34g～38g, parasitic loranthus 26g～30g, Kaempferia galanga 22g～26g, Rose Mallow Root 23g～27g, milfoil 20g～24g, suchow mosla herb 29g～33g, horse sour jujube 28g～32g, saururus chinensis 22g～26g, leaf of negundo chastetree 23g～27g, fruit of Chinese magnoliavine 32g～36g, kuh-seng 26g～30g, Radix Angelicae Sinensis 33g～37g, subprostrate sophora 28g～32g, pyrola 31g～35g, gynostemma pentaphylla 33g～37g and radix bupleuri 28g～32g.
Wherein, the weight of described each bulk drug is respectively dandelion 27g, coptis 55g, Chinese ephedra 36g, cassia twig 30g, Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus 28g, Kaempferia galanga 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g, leaf of negundo chastetree 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, subprostrate sophora 30g, pyrola 33g, gynostemma pentaphylla 35g and radix bupleuri 30g.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition feed addictive, is specially:
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into stirrer for mixing according to above-mentioned weight even, mixture is packed in percolator, every 100g mixture adds the white wine 500g～700g of 50 DEG C～55 DEG C, under the condition of 25 DEG C～35 DEG C, soak 20 hours～30 hours, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2～4mL per minute, collect drip, obtain the percolate of 700mL～1L, concentrated, remove white wine, dry, pulverize, obtain dry powder,
Second step, sends remaining component into stirrer for mixing even by weight, every 100g mixture, add the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition feed addictive.
It is a kind of for preventing and treating the feed of swine influenza that the present invention also provides, and its raw material comprises corn, dregs of beans, salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, VitAVitE, ethoxyquinoline and above-mentioned for preventing and treating the Chinese medicine composition feed addictive of swine influenza.
Wherein, in described feed, the weight portion of each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans 140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weight portions, soya-bean oil 20 weight portion～30 weight portions, zinc methionine 0.5 weight portion～1.5 weight portion, Copper lysinate 0.5 weight portion～1.5 weight portion, tryptophan 0.5 weight portion～1.5 weight portion, retinol1 weight portion～2 weight portion, vitamin e1 weight portion～2 weight portion, ethoxyquinoline 2 weight portion～4 weight portions, Chinese medicine composition feed addictive 30 weight portion～50 weight portions.
Further, in described feed, the weight portion of each raw material is respectively corn 300 weight portions, dregs of beans 150 weight portions, salt 4 weight portions, fish meal 35 weight portions, soya-bean oil 25 weight portions, zinc methionine 1 weight portion, Copper lysinate 1 weight portion, tryptophan 1 weight portion, dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portions, Chinese medicine composition feed addictive 40 weight portions.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares described Chinese medicine composition feed addictive;
Second step, puts into fodder mixing machine together with the described Chinese medicine composition feed addictive that other raw material components in feedstuff and the first step are obtained, and continuous uniform stirred after 1～3 hour, put into pulverizer and pulverized, and obtained feed.
Beneficial effect of the present invention:
Provided by the invention abundant for preventing and treating the Chinese medicine composition feed addictive of swine influenza and adopting the feed of this feed addictive to there is medicine source, residual hazard is lower or without residual hazard, side effect is little, be difficult for producing resistance, it can regulate body's immunity, suppress virus replication, improve illness symptom, there is significant effect preventing and treating aspect swine influenza.
Detailed description of the invention
The invention provides a kind ofly for preventing and treating the Chinese medicine composition feed addictive of swine influenza, its bulk drug comprises dandelion, the coptis, Chinese ephedra, cassia twig, Morinda officinalis, the bighead atractylodes rhizome, Companumoea root, Gorgon fruit, the fruit of glossy privet, parasitic loranthus, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, leaf of negundo chastetree, the fruit of Chinese magnoliavine, kuh-seng, Radix Angelicae Sinensis, subprostrate sophora, pyrola, gynostemma pentaphylla and radix bupleuri.
Further, described Chinese medicine composition feed addictive is only made up of above-mentioned raw materials medicine.
The weight of described each bulk drug is respectively dandelion 22g～32g, coptis 50g～60g, Chinese ephedra 31g～41g, cassia twig 25g～35g, Morinda officinalis 30g～40g, bighead atractylodes rhizome 27g～37g, Companumoea root 30g～40g, Gorgon fruit 25g～35g, fruit of glossy privet 31g～41g, parasitic loranthus 23g～33g, Kaempferia galanga 19g～29g, Rose Mallow Root 20g～30g, milfoil 17g～27g, suchow mosla herb 26g～36g, horse sour jujube 25g～35g, saururus chinensis 19g～29g, leaf of negundo chastetree 20g～30g, fruit of Chinese magnoliavine 29g～39g, kuh-seng 23g～33g, Radix Angelicae Sinensis 30g～40g, subprostrate sophora 25g～35g, pyrola 28g～38g, gynostemma pentaphylla 30g～40g and radix bupleuri 25g～35g.
Further preferably, the weight of described each bulk drug is respectively dandelion 25g～29g, coptis 53g～57g, Chinese ephedra 34g～38g, cassia twig 28g～32g, Morinda officinalis 33g～37g, bighead atractylodes rhizome 30g～34g, Companumoea root 33g～37g, Gorgon fruit 28g～32g, fruit of glossy privet 34g～38g, parasitic loranthus 26g～30g, Kaempferia galanga 22g～26g, Rose Mallow Root 23g～27g, milfoil 20g～24g, suchow mosla herb 29g～33g, horse sour jujube 28g～32g, saururus chinensis 22g～26g, leaf of negundo chastetree 23g～27g, fruit of Chinese magnoliavine 32g～36g, kuh-seng 26g～30g, Radix Angelicae Sinensis 33g～37g, subprostrate sophora 28g～32g, pyrola 31g～35g, gynostemma pentaphylla 33g～37g and radix bupleuri 28g～32g.
Have most choosing, the weight of described each bulk drug is respectively dandelion 27g, coptis 55g, Chinese ephedra 36g, cassia twig 30g, Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus 28g, Kaempferia galanga 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g, leaf of negundo chastetree 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, subprostrate sophora 30g, pyrola 33g, gynostemma pentaphylla 35g and radix bupleuri 30g.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition feed addictive, is specially:
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into stirrer for mixing according to above-mentioned weight even, mixture is packed in percolator, every 100g mixture adds the white wine 500g～700g of 50 DEG C～55 DEG C, under the condition of 25 DEG C～35 DEG C, soak 20 hours～30 hours, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2～4mL per minute, collect drip, obtain the percolate of 700mL～1L, concentrated, remove white wine, dry, pulverize, obtain dry powder,
Second step, sends remaining component into stirrer for mixing even by weight, every 100g mixture, add the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition feed addictive.
Each bulk drug pharmacology is as follows:
Dandelion: latin name Taraxaci Herba, taste is sweet, bitter, cold in nature, enter liver, stomach warp, there is clearing heat and detoxicating, the carbuncle that disappears dissipating bind, clear liver and improve vision, the effect of inducing diuresis for treating strangurtia, be mainly used in the control of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the cards such as the red eye, swell pain of liver-fire flaming.
The coptis: bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, the effect of cooling blood for improving eyesight, is usually used in preventing and treating the fire of removing the heart-fire warp, the dysphoria and insomnia that internal heat is prosperous, and the high fever coma of warm heat disease, the symptom such as vexed, thirsty.
Chinese ephedra: pungent, the micro-hardship of taste, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, to freeing lung and relieving asthma, the effect of inducing diuresis for removing edema, is mainly used in the superficies excess syndromes such as the fever without perspiration of catching cold; Rheumatic numbness pain; Pathogenic cold attacking the lung or accumulation of heat in the lung are to coughing the cards such as contrary, oedema, difficult urination of breathing.
Cassia twig: latin name cinnamomi ramulus, for canella Chinese cassia tree is dried spray: taste is pungent, sweet, warm in nature, the thoughts of returning home, lung, urinary bladder channel, there is sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, the effect of eliminating cold to stop pain, warming meridians and promoting circulation of qi, horizontal logical podomere, for the illness that has not attacked the vital organs of the human body of catching cold, no matter have sweat, losslessly all can apply, also for arthralgia due to wind-dampness, stomach cold stomachache, through closing, dysmenorrhoea, arthralgia due to wind-dampness, the cards such as shoulder arm podomere crymodynia, phlegm retention syndrome and bladder retaining, the heart is insufficiency of the spleen-yang, retention of water-damp in the body, fullness in chest and hypochondrium, coughs the contrary dizzy phlegm retention syndrome that waits.
Morinda officinalis: taste is pungent, sweet, slightly warm in nature, enters liver, kidney channel, has the effect of kidney-replenishing, strengthening the bones and muscles, wines used as antirheumatic, and for impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen crymodynia, palace is cold infertile, the cards such as muscles and bones impotence due to kidney deficiency and liver is soft, waist knee crymodynia.
The bighead atractylodes rhizome: latin name atractylodis macrocephalae rhizoma, bitter, sweet, warm in nature, enter spleen, stomach warp, there is strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive effect, for weakness of the spleen and the stomach, the few turgor of food, lassitude hypodynamia, has loose bowels, water-damp retention, phlegm and retained fluid, oedema, the cards such as exterior deficiency spontaneous perspiration, have the gastrointestinal motility function of adjustment, antiulcer, protect the liver, enhanced machine body immunity function, anti-ly stress, strengthen the effects such as hematopoiesis function
Companumoea root: latin name radix campanumoea javanicae is the root of Campanulaceae leopard platymiscium Campanumoea javanica and leopard, and taste is sweet, property is put down, and returns lung, the spleen channel, has strengthening the spleen and replenishing qi, tonifies the lung to relieve cough, effect of lactogenesis, cures mainly the empty internal injury of labor, and the deficiency of vital energy is weak, palpitaition, hidrosis, splenasthenic diarrhea, leukorrhea, milk rareness, the cards such as insufficiency of the spleen cough.
Gorgon fruit: taste is sweet, puckery, property is flat, returns spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, clearing damp is the function of band only, cures mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, is with inferior card.
The fruit of glossy privet: taste is sweet, bitter, is slightly cold, enters liver, kidney channel, has strong liver kidney-nourishing, and the effect of removing heat to brighten vision, is mainly used in preventing and treating liver-kidney Yin deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.The fruit of glossy privet can promote leucocyte, strengthens effect of immunologic function, and staphylococcus aureus, shigella dysenteriae are had to stronger inhibitory action.
Parasitic loranthus: bitter, sweet, property is flat, enters liver, kidney channel, have the effect of filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic, antiabortive unit, for the soreness of waist pain due to kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, kidney deficiency and liver, essence and blood is empty to be lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.
Kaempferia galanga: latin name kaempferiae rhizoma is the rhizome of Zingiber Kaempferia plant Kaempferia galanga, and warm in nature, taste is pungent, returns stomach warp, has in temperature, helps digestion, and effect of pain relieving, cures mainly trusted subordinate's crymodynia, stops dyspepsia, traumatic injury, toothache, the diet card such as do not disappear.
Rose Mallow Root: taste is sweet, light, property is flat, enters the heart, lung channel, has expelling wind and removing dampness, and clearing heat and detoxicating effect, cures mainly cold, fever, arthralgia due to wind-dampness, dysentery, oedema, leukorrhea, spits blood, and carbuncle is swollen, traumatism and bleeding, venomous snake bite, acute infantile convulsions, lockjaw, asthma, the cards such as stomachache cold after delivery.
Milfoil: taste is pungent; Bitter; Property flat temperature, there is wind-expelling pain-stopping; Effect of promoting blood circulation and detoxication, cures mainly cold, fever; Wind pain; Toothache; Arthralgia due to wind-dampness; Blood stasis is through closing; Belly lump in the abdomen; Traumatic injury; Venomous snake bite; The cards such as carbuncle sore tumefacting virus.
Suchow mosla herb: warm in nature, taste is pungent, has dispelling summer-heat to relieve superficies syndrome, effect of regulating qi-flowing for relieving pain, cures mainly flu, heatstroke, eruptive disease, peratodynia, the cards such as abscess of throat.
Horse sour jujube: bitter, puckery, property is flat, has clearing heat and detoxicatingly, and loose long-pending effect of stagnation resolvation, cures mainly anemopyretic cold, cough with lung heat, furunculosis, acute mastitis, traumatic injury, dyspeptic abdominal distention, the cards such as venomous snake bite.
Saururus chinensis: latin name Saururi Herba, taste is sweet, pungent, cold in nature, returns lung, urinary bladder channel, has heat-clearing profit distilled water; Effect of removing toxicity for detumescence, cures mainly heat and drenches; Blood drenches; Distillation oedema; Beriberi; Jaundice; Dysentery; Under band; Carbuncle sore tumefacting virus; Eczema; The cards such as snake bite.
Leaf of negundo chastetree: latin name Viticis NegundoFolium, taste is pungent; Bitter; Property is put down, and returns lung channel, has the dampness elimination of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expels pathogenic wind from the body surface, dehumidifying, and desinsection, effect of pain relieving, cures mainly cold, cough, asthma; Stomachache; Stomachache; Summer-heat and damp is rushed down dysentery; Beriberi swelling; Rubella itch; The ringworm of the foot; Acute mastitis swells and ache; The cards such as snake bite and insect sting.
The fruit of Chinese magnoliavine: warm in nature, taste acid, sweet, enters lung, the heart, kidney channel, has convergence astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, the effect of kidney calming.Breathe heavily for the void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the feeble pulse of losing heart, interior heat is quenched one's thirst, the cards such as palpitation and insomnia.
Kuh-seng: bitter, cold in nature, enter liver, kidney, large intestine, small intestine, bladder, the heart channel of Hang-Shaoyin, there is heat-clearing and damp-drying drug, effect of wind dispelling insecticide, cures mainly damp-heat dysentery, hematochezia, jaundice, difficult urination, oedema, under band, pruritus vulvae, mange, leprosy, pruitus, the cards such as eczema of lower limb ulcer.
Radix Angelicae Sinensis: taste is sweet, pungent, warm in nature, enters liver, the heart, the spleen channel, and enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect relaxing bowel, is mainly used in having a dizzy spell of deficiency of heart-blood, lassitude hypodynamia, palpitation, and other syndrome of blood deficiency; Sea of blood inanition, the irregular menstruation of the cold and deficiency of chong and ren channels or extravasated blood retardance, dysmenorrhoea, produces or stomachache, and the symptom such as the constipation that other blood stasis are had a pain and the few intestines of deficiency of Yin blood are dry, its can improve uterus blood circulation, alleviate pelvic congestion, the cards such as relieving dysmenorrhea.
Subprostrate sophora: bitter, cold in nature, enter the heart, lung, large intestine channel, there is removing toxic substances relieve sore throat, clearing heat and promoting diuresis, effect that desinsection is anticancer, for abscess of throat, the gum dentalgia that swells, cough with lung heat, dysentery, jaundice, the cards such as the swollen favus of the scalp of heat, especially have good effect preventing and treating in the cancers such as nasopharyngeal carcinoma.
Pyrola: taste is sweet, bitter, warm in nature, enter lung channel, stomach warp, Liver Channel, kidney channel, can qi-restoratives, kidney-nourishing, dispel rheumatism, promoting blood circulation for regulating menstruation, the strong bone of kidney tonifying, dispel rheumatism, cough-relieving, hemostasis, cure mainly that main lumbago due to the kidney deficiency, arthralgia due to wind-dampness, soft, the new chronic cough of muscles and bones impotence are coughed, haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatism and bleeding.
Gynostemma pentaphylla: another name seven leaf courages, Pentapanax leschenaultii, gynostemma pentaphyllum makino, Herba Gynostemmatis, the public arched end, Radix Rhodiolae, the sweet bitter edible plant are climing, southern ginseng, cold in nature, bitter, returns lung, spleen, kidney channel, and useful gas, calms the nerves, hypotensive effect, for deficiency of vital energy and physically weak, weak breath is weak; Vexed insomnia; High blood pressure, Light-headedness; Virus hepatitis; Tumor in digestive tract; The cards such as chronic bronchitis, find through modern medicine study, the main active ingredient of gynostemma pentaphylla is polysaccharide, flavonoids, saponins and microelement kind, and its effect is mainly to promote body fat class metabolism, nutrition human body cell, has good detoxicating, relieving inflammation effect simultaneously.
Radix bupleuri: latin name bupleuri radix is the dry root of umbelliferae bupleurum or radix bupleuri scorzoneraefolii, bitter, cold nature, return liver, gallbladder channel, have to evacuate and bring down a fever, rise effect of the easypro liver of sun, cure mainly cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, the cards such as uterus comes off, irregular menstruation.
It is a kind of for preventing and treating the feed of swine influenza that the present invention also provides, and its raw material comprises corn, dregs of beans, salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, VitAVitE, ethoxyquinoline and above-mentioned for preventing and treating the Chinese medicine composition feed addictive of swine influenza.
Further, described feed is only made up of above-mentioned raw materials.
Further, in described feed, the weight portion of each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans 140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weight portions, soya-bean oil 20 weight portion～30 weight portions, zinc methionine 0.5 weight portion～1.5 weight portion, Copper lysinate 0.5 weight portion～1.5 weight portion, tryptophan 0.5 weight portion～1.5 weight portion, retinol1 weight portion～2 weight portion, vitamin e1 weight portion～2 weight portion, ethoxyquinoline 2 weight portion～4 weight portions, Chinese medicine composition feed addictive 30 weight portion～50 weight portions.
Further, in described feed, the weight portion of each raw material is respectively corn 300 weight portions, dregs of beans 150 weight portions, salt 4 weight portions, fish meal 35 weight portions, soya-bean oil 25 weight portions, zinc methionine 1 weight portion, Copper lysinate 1 weight portion, tryptophan 1 weight portion, dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portions, Chinese medicine composition feed addictive 40 weight portions.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares described Chinese medicine composition feed addictive;
Second step, puts into fodder mixing machine together with the described Chinese medicine composition feed addictive that other raw material components in feedstuff and the first step are obtained, and continuous uniform stirred after 1～3 hour, put into pulverizer and pulverized, and obtained feed.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition feed addictive 1
By dandelion 27g, coptis 55g, Chinese ephedra 36g, cassia twig 30g, Kaempferia galanga 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g, subprostrate sophora 30g, pyrola 33g and radix bupleuri 30g pulverize respectively, send into stirrer for mixing even, and mixture is packed in percolator, every 100g mixture adds the white wine 600g of 55 DEG C, soaks 25 hours under the condition of 30 DEG C, regulates percolator valve, white wine liquid is slowly oozed, and the speed of oozing is 3mL per minute, collects drip, obtain the percolate of 800ml, concentrated, remove white wine, dry, pulverize, obtain dry powder, by Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus 28g, leaf of negundo chastetree 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, it is even that gynostemma pentaphylla 35g sends into stirrer for mixing, and every 100g mixture adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder, the dry powder obtaining is above mixed, obtain Chinese medicine composition feed addictive 1.
Embodiment 2 Chinese medicine composition feed addictives 2
By dandelion 25g, coptis 53g, Chinese ephedra 34g, cassia twig 28g, Kaempferia galanga 22g, Rose Mallow Root 23g, milfoil 20g, suchow mosla herb 29g, horse sour jujube 28g, saururus chinensis 22g, subprostrate sophora 28g, pyrola 31g and radix bupleuri 28g pulverize respectively, send into stirrer for mixing even, and mixture is packed in percolator, every 100g mixture adds the white wine 600g of 55 DEG C, soaks 25 hours under the condition of 30 DEG C, regulates percolator valve, white wine liquid is slowly oozed, and the speed of oozing is 3mL per minute, collects drip, obtain the percolate of 800ml, concentrated, remove white wine, dry, pulverize, obtain dry powder, by Morinda officinalis 33g, bighead atractylodes rhizome 30g, Companumoea root 33g, Gorgon fruit 28g, fruit of glossy privet 34g, parasitic loranthus 26g, leaf of negundo chastetree 23g, fruit of Chinese magnoliavine 32g, kuh-seng 26g, Radix Angelicae Sinensis 33g, it is even that gynostemma pentaphylla 33g sends into stirrer for mixing, and every 100g mixture adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder, the dry powder obtaining is above mixed, obtain Chinese medicine composition feed addictive 2.
Embodiment 3 Chinese medicine composition feed addictives 3
By dandelion 29g, coptis 57g, Chinese ephedra 38g, cassia twig 32g, Kaempferia galanga 26g, Rose Mallow Root 27g, milfoil 24g, suchow mosla herb 33g, horse sour jujube 32g, saururus chinensis 26g, subprostrate sophora 32g, pyrola 35g and radix bupleuri 32g pulverize respectively, send into stirrer for mixing even, and mixture is packed in percolator, every 100g mixture adds the white wine 600g of 55 DEG C, soaks 25 hours under the condition of 30 DEG C, regulates percolator valve, white wine liquid is slowly oozed, and the speed of oozing is 3mL per minute, collects drip, obtain the percolate of 800ml, concentrated, remove white wine, dry, pulverize, obtain dry powder, by Morinda officinalis 37g, bighead atractylodes rhizome 34g, Companumoea root 37g, Gorgon fruit 32g, fruit of glossy privet 38g, parasitic loranthus 30g, leaf of negundo chastetree 27g, fruit of Chinese magnoliavine 36g, kuh-seng 30g, Radix Angelicae Sinensis 37g, it is even that gynostemma pentaphylla 37g sends into stirrer for mixing, and every 100g mixture adds the water of 600g, boil 4 hours, filter, obtain the first filtrate, filter residue adds the water of 300g again, again boils 2 hours, filters, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder, the dry powder obtaining is above mixed, obtain Chinese medicine composition feed addictive 3.
Embodiment 4 toxicology tests
Acute toxicity testing
Select 20 of Kunming mouses, female half and half, body weight (20+2) g, provided by Qingdao City's Experimental Animal Center, Chinese medicine composition additive prepared by embodiment 1 is dissolved in distilled water, is prepared into the solution of 1g/ml, gavages mouse, through preliminary experiment, fail to detect the LD of oral administration
50therefore, survey its maximal tolerance dose, with the administration volume of 2.0ml/10g body weight, gavage 2 times/d, interval 6h, gives observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, by all animals processing, dissect, visually observe each main organs lesion tissue situation, gavage for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the obviously abnormal of main organs tissue.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, provided by Qingdao City's Experimental Animal Center, be divided at random 2 groups, blank group and Chinese drug-treated group, every group 20, blank group gives distilled water, the Chinese medicine composition additive that Chinese drug-treated group is prepared embodiment 1 is dissolved in distilled water, be prepared into the solution of 1g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, 180d continuously, administration volume is 2mL/100g body weight, observe rat general state every day before administration and during administration, sign, food ration, drinking-water and ight soil situation.When administration 90d, after last administration 24h, each group extracts 6, male and female half and half; When 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, 30d respectively organizes and extracts 6, male and female half and half, anaesthetize with urethane, get blood from abdominal aortic, each group is all killed and gets animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid gland, thymus gland, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.
On inspection, during successive administration, activity, body weight, food ration, stool and the hair luster degree no abnormality seen of animal, it is dead that animal has no, naked eyes have no obvious pathology, the inspection of each group rat peripheral hemogram is all in normal range (NR), and the raw tea index of blood is all in normal range (NR), and Chinese drug-treated group Rats Organs and Tissues coefficient does not have significant difference compared with blank group.
Embodiment 5 feeds
Chinese medicine composition feed addictive 40kg prepared by corn 300kg, dregs of beans 150kg, salt 4kg, fish meal 35kg, soya-bean oil 25kg, zinc methionine 1kg, Copper lysinate 1kg, tryptophan 1kg, dehydroretinol kg, vitamin E2 kg, ethoxyquinoline 3kg, embodiment 1 puts into fodder mixing machine together, continuous uniform stirred after 3 hours, put into pulverizer and pulverize, obtain feed.
Embodiment 6 effect tests
Material
A/swine/Hebei/012/2008 (H9N2), provide and separate preservation by animal virus Molecular Biology Lab of Hebei North University, go down to posterity through 10 age in days chick embryo allantoic cavity inoculated and cultured, Microhemagglutination test titration virus titer, tiring is 1: 256; The SPF level BALB/c small white mouse in 6～8 week age, body weight 18～22g, male and female half and half, Chinese medicine composition feed addictive 1 prepared by embodiment 1, ribavirin granule (Ribavirin), is purchased from Hua Shengtang bio tech ltd, Beijing.
Experimental design
Experimental animal is divided into Normal group, infection model group (infected pigs's not administration of influenza virus), Ribavirin group (10mg/kgd), Chinese medicine composition group (400mg/kgd), all administration after mouse infection influenza virus.
Infection method
With the slight anesthetized mice of ether, Normal group is with physiological saline collunarium, every 50 μ l, and all the other each group with 50 μ l H9N2 strain virus drop noses, and wherein in dead protection test, infective dose is 25LD
50, other experimental infection amounts are 1/3LD
50.
Medication
Chinese medicine composition feed addictive prepared by embodiment 1 is dissolved in water, is heated to dissolve completely, filters, be concentrated into 1g/ml, mouse stomach administration after infection 4h, each 0.2ml, every day 2 times, continuously 5d, normal blank group, infection model group gavage physiological saline 0.2ml.
The LD of H9N2
50mensuration
By influenza virus stock solution (chick embryo allantoic liquid) doubling dilution of collecting, obtain 10
-1, 10
-2, 10
-3, 10
-4, 10
-5the virus liquid of concentration.Get 48 of mouse, be divided into 6 groups with random sampling, after anesthesia that ether is slight, collunarium infects different dilution factor virus liquid 0.05ml, and taking dead and existence as observation index, in 24h, death will not add up.Observe every day, until infect latter the 14th day.Calculate viral median lethal dose (LD
50).
To the test of the dead protection of H9N2 infecting mouse
Infect according to infection method above-mentioned, administration 5d observes animal disease symptom day by day, record the death time, death toll, observe altogether 14d, be calculated as follows result: dead protective rate (%)=(the infection model group death rate-test group death rate)/infection model group death rate × 100; Extending life rate (%)=(test group on average survive number of days-infection model group on average survive number of days)/infection model group number of days × 100 of on average surviving.
Lung index, lung index and lung suspension viral hemoagglutination titer determination
After mouse medication the 5th day, first fasting water 8h, after weighing, pluck eyeball sacrificed by exsanguination mouse, open thoracic cavity and extract full lung, with physiological saline washing 2 times, filter paper blots surperficial moisture content, claims lung weight, calculates lung exponential sum lung index: lung index=(mouse lung weight/Mouse Weight) × 100% by following formula; Lung index=(the average lung index of the average lung index-experimental group of infection model group) average lung index × 100% of/infection model group.With adding physiological saline [lung heavy (g): physiological saline (ml)=1: 9] in rearmounted homogenizer, grind and make homogenate, centrifugal (4 DEG C, 2500rpm × 30min) are got supernatant and are carried out according to a conventional method Microhemagglutination test.
Index and spleen index and thymus index are measured
After mouse medication the 5th day, fasting water 8h, after weighing, pluck eyeball sacrificed by exsanguination mouse, extraction spleen and thymus gland, physiological saline washing 2 times, filter paper blots surperficial moisture content, claims lung weight, calculates one by one index and spleen index: index and spleen index=(mice spleen weight/Mouse Weight) × 100% by following formula; Thymus index=(mouse thymus weight/Mouse Weight) × 100%.
Data processing
Measurement data adopts
represent, between group, relatively adopt χ
2inspection, all data all adopt the processing of SPSS12.0 statistical software.
Results and analysis
The LD of H9N2
50
Mouse infection the 3rd day, all there is disease symptom in various degree in front 3 groups of mouse: lassitude, shake, pant, degradation under diet; Within the 5th day, infecting mouse starts to occur walking pendulous symptom; The 6th day the 1st group
The highest viral level group mouse starts to occur dead, and all the other each group in infecting the rear the 8th
It occurs dead successively.Observe altogether 14d, add up each group of dead mouse number (table 1).Calculate the LD of this influenza virus
50be 2.49.Distance proportion=(higher than 50% accumulative total per cent death loss-50%)/(higher than 50% accumulative total per cent death loss-lower than 50% accumulative total per cent death loss)=85.71-50/85.71-14.28=0.49.
Median lethal dose (the LD of table 1H9N2 Strain
50) calculate
| Dilution factor | Death toll | Dead accumulative total | Survival accumulative total | Dead ratio | Dead accumulative total rate/% |
| 10 -1 | 8 | 20 | 0 | 20/20 | 100.0 |
| 10 -2 | 6 | 12 | 2 | 12/14 | 85.7 |
| 10 -3 | 4 | 6 | 6 | 6/12 | 50.0 |
| 10 -4 | 2 | 2 | 12 | 2/14 | 14.3 |
| 10 -5 | 0 | 0 | 20 | 0/20 | 0 |
The death protection result of Chinese medicine composition feed addictive to H9N2 virus infected mice, the results are shown in Table 2.
The death protection result of table 2 Chinese medicine composition feed addictive to H9N2 virus infected mice
Chinese medicine composition group and Ribavirin group are compared with infection model group, the death rate obviously reduces (P < 0.01), the mean survival time of mouse obviously extends (P < 0.01) (table 2), and visible Chinese medicine composition can effectively resist the pathogenic effects of swine influenza virus.
The impact of Chinese medicine composition on blood clotting titre in swine influenza virus Lung Index of mice infected by Influenza virus, lung index and lung tissue, the results are shown in Table 3.
The impact of table 3 Chinese medicine composition on blood clotting titre in swine influenza virus Lung Index of mice infected by Influenza virus, lung index and lung tissue
Lung index result shows: the blank group of infection model group compared with normal lung index obviously raises, and difference is (P < 0.01) extremely significantly; Chinese medicine composition group and Ribavirin are prevented and treated group and are reduced (P < 0.01) compared with infection model group lung index, and Chinese drug-treated group and Ribavirin group are without significant difference.
The impact of Chinese medicine composition on swine influenza virus infecting mouse index and spleen index and thymus index, the results are shown in Table 4.
The impact of table 4 Chinese medicine composition on swine influenza virus infecting mouse index and spleen index and thymus index
As shown in Table 4, after pig virus infected mice, infection model group index and spleen index reduces, and compares with normal blank group, and difference is (P < 0.01) extremely significantly; Ribavirin group and the comparison of infection model group, there were significant differences (P < 0.05); After swine influenza virus infecting mouse, infection model group thymus index reduces, and compares with normal blank group, has utmost point significant difference (P < 0.01); Compound Chinese medicinal preparation group and Ribavirin group thymus index increase compared with infection model group, and difference is (P < 0.01) extremely significantly.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. for preventing and treating the feed of swine influenza, it is characterized in that: raw material comprises corn, dregs of beans, salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, VitAVitE, ethoxyquinoline and for preventing and treating the Chinese medicine composition feed addictive of swine influenza.
2. feed as claimed in claim 1, it is characterized in that: in described feed, the weight portion of each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans 140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weight portions, soya-bean oil 20 weight portion～30 weight portions, zinc methionine 0.5 weight portion～1.5 weight portion, Copper lysinate 0.5 weight portion～1.5 weight portion, tryptophan 0.5 weight portion～1.5 weight portion, retinol1 weight portion～2 weight portion, vitamin e1 weight portion～2 weight portion, ethoxyquinoline 2 weight portion～4 weight portions, Chinese medicine composition feed addictive 30 weight portion～50 weight portions.
3. feed as claimed in claim 1 or 2, is characterized in that: in described feed, the weight portion of each raw material is respectively corn 300 weight portions, dregs of beans 150 weight portions, salt 4 weight portions, fish meal 35 weight portions, soya-bean oil 25 weight portions, zinc methionine 1 weight portion, Copper lysinate 1 weight portion, tryptophan 1 weight portion, dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portions, Chinese medicine composition feed addictive 40 weight portions.
4. the feed as described in claims 1 to 3, is characterized in that: the bulk drug of described Chinese medicine composition feed addictive comprises dandelion, the coptis, Chinese ephedra, cassia twig, Morinda officinalis, the bighead atractylodes rhizome, Companumoea root, Gorgon fruit, the fruit of glossy privet, parasitic loranthus, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, leaf of negundo chastetree, the fruit of Chinese magnoliavine, kuh-seng, Radix Angelicae Sinensis, subprostrate sophora, pyrola, gynostemma pentaphylla and radix bupleuri.
5. the feed as described in claim 1 to 4, it is characterized in that: the weight of each bulk drug of described Chinese medicine composition feed addictive is respectively dandelion 22g～32g, coptis 50g～60g, Chinese ephedra 31g～41g, cassia twig 25g～35g, Morinda officinalis 30g～40g, bighead atractylodes rhizome 27g～37g, Companumoea root 30g～40g, Gorgon fruit 25g～35g, fruit of glossy privet 31g～41g, parasitic loranthus 23g～33g, Kaempferia galanga 19g～29g, Rose Mallow Root 20g～30g, milfoil 17g～27g, suchow mosla herb 26g～36g, horse sour jujube 25g～35g, saururus chinensis 19g～29g, leaf of negundo chastetree 20g～30g, fruit of Chinese magnoliavine 29g～39g, kuh-seng 23g～33g, Radix Angelicae Sinensis 30g～40g, subprostrate sophora 25g～35g, pyrola 28g～38g, gynostemma pentaphylla 30g～40g and radix bupleuri 25g～35g.
6. the feed as described in claim 1 to 5, it is characterized in that: the weight of each bulk drug of described Chinese medicine composition feed addictive is respectively dandelion 25g～29g, coptis 53g～57g, Chinese ephedra 34g～38g, cassia twig 28g～32g, Morinda officinalis 33g～37g, bighead atractylodes rhizome 30g～34g, Companumoea root 33g～37g, Gorgon fruit 28g～32g, fruit of glossy privet 34g～38g, parasitic loranthus 26g～30g, Kaempferia galanga 22g～26g, Rose Mallow Root 23g～27g, milfoil 20g～24g, suchow mosla herb 29g～33g, horse sour jujube 28g～32g, saururus chinensis 22g～26g, leaf of negundo chastetree 23g～27g, fruit of Chinese magnoliavine 32g～36g, kuh-seng 26g～30g, Radix Angelicae Sinensis 33g～37g, subprostrate sophora 28g～32g, pyrola 31g～35g, gynostemma pentaphylla 33g～37g and radix bupleuri 28g～32g.
7. the feed as described in claim 1 to 6, is characterized in that: the weight of each bulk drug of described Chinese medicine composition feed addictive is respectively dandelion 27g, coptis 55g, Chinese ephedra 36g, cassia twig 30g, Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus 28g, Kaempferia galanga 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g, leaf of negundo chastetree 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, subprostrate sophora 30g, pyrola 33g, gynostemma pentaphylla 35g and radix bupleuri 30g.
8. the feed as described in claim 1 to 7, is characterized in that: the preparation method of described Chinese medicine composition feed addictive, comprise,
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into stirrer for mixing according to above-mentioned weight even, mixture is packed in percolator, every 100g mixture adds the white wine 500g～700g of 50 DEG C～55 DEG C, under the condition of 25 DEG C～35 DEG C, soak 20 hours～30 hours, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2～4mL per minute, collect drip, obtain the percolate of 700mL～1L, concentrated, remove white wine, dry, pulverize, obtain dry powder,
Second step, sends remaining component into stirrer for mixing even by weight, every 100g mixture, add the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition feed addictive.
9. the preparation method of feed described in claim 1 to 8, is characterized in that, comprising:
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into stirrer for mixing according to above-mentioned weight even, mixture is packed in percolator, every 100g mixture adds the white wine 500g～700g of 50 DEG C～55 DEG C, under the condition of 25 DEG C～35 DEG C, soak 20 hours～30 hours, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 2～4mL per minute, collect drip, obtain the percolate of 700mL～1L, concentrated, remove white wine, dry, pulverize, obtain dry powder,
Second step, sends remaining component into stirrer for mixing even by weight, every 100g mixture, add the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds the water of 200g～300g again, again boils 1～2 hour, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, the concentrated aqueous solvent of removing, pulverize, dry, obtain dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition feed addictive;
The 4th step, puts into fodder mixing machine together with the described Chinese medicine composition feed addictive that other raw material components in feedstuff are obtained with the 3rd step, and continuous uniform stirred after 1～3 hour, put into pulverizer and pulverized, and obtained feed.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104366018A (en) * | 2014-12-10 | 2015-02-25 | 叶红 | Feed for preventing swine influenza and method for manufacturing feed |
| CN106852406A (en) * | 2016-12-05 | 2017-06-16 | 柳州绿旺科技养殖管理有限责任公司 | A kind of pig feed of strengthen immunity |
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|---|---|---|---|---|
| CN101120732A (en) * | 2007-09-07 | 2008-02-13 | 济南和美华饲料有限公司 | Feed for promoting nursery pig immunity |
| CN102772492A (en) * | 2012-06-30 | 2012-11-14 | 王志坚 | Traditional Chinese medicine feed additive for preventing and treating swine influenza |
| CN103750060A (en) * | 2014-01-27 | 2014-04-30 | 山东新希望六和集团有限公司 | Feed for treating pig influenza and preparation method thereof |
-
2014
- 2014-05-28 CN CN201410230988.0A patent/CN104082538B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120732A (en) * | 2007-09-07 | 2008-02-13 | 济南和美华饲料有限公司 | Feed for promoting nursery pig immunity |
| CN102772492A (en) * | 2012-06-30 | 2012-11-14 | 王志坚 | Traditional Chinese medicine feed additive for preventing and treating swine influenza |
| CN103750060A (en) * | 2014-01-27 | 2014-04-30 | 山东新希望六和集团有限公司 | Feed for treating pig influenza and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104366018A (en) * | 2014-12-10 | 2015-02-25 | 叶红 | Feed for preventing swine influenza and method for manufacturing feed |
| CN106852406A (en) * | 2016-12-05 | 2017-06-16 | 柳州绿旺科技养殖管理有限责任公司 | A kind of pig feed of strengthen immunity |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104082538B (en) | 2016-05-11 |
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Denomination of invention: Feed for controlling pig influenza Effective date of registration: 20181229 Granted publication date: 20160511 Pledgee: Suining Suizhou Branch of Agricultural Bank of China Limited Pledgor: Complete Limited by Share Ltd Registration number: 2018510000143 |