CN104082538B - For preventing and treating the feed of swine influenza - Google Patents
For preventing and treating the feed of swine influenza Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a kind ofly for preventing and treating the feed of swine influenza, its raw material comprises corn, dregs of beans, salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, VitAVitE, ethoxyquinoline and for preventing and treating the Chinese medicine composition feed addictive of swine influenza. This Chinese medicine composition feed addictive has that medicine source is abundant, and residual hazard is lower or without residual hazard, side effect is little, is difficult for producing resistance, and it can regulate body's immunity, suppresses virus replication, improves illness symptom, has significant effect preventing and treating aspect swine influenza.
Description
Technical field
The present invention relates to field of feed, relate in particular to a kind of for preventing and treating the feed of swine influenza.
Background technology
Swine flu claims again swine influenza, is the swine flu disease by the A of orthomyxovirus section type Influenza VirusOne that poison causes is acute, hot, height contact respiratory infectious disease, clinical with burst, high heat,Cough, expiratory dyspnea, outbreak repeatedly, the incidence of disease is high, the death rate is low is feature.
Swine flu be large scale of pig farm field ubiquity and be difficult to eradicate the swinery property sent out disease, not only can be straightConnect and cause affected pig death, and affected pig production performance is declined, recover slowly, to postpone listing directly shadowRing the quality of swinery health status and pig, very harmful to pig industry. More significant, swine fluVirus is that the primary of " porcine respiratory disease syndrome " is pathogenic former, because swine influenza virus is on respiratory tractLeatherware has high special parent preferendum and makes airway epithelial tube wall impaired, cause Actinobacillus pleuropneumoniae,Haemophilus, Pasteurella, pig 2 type streptococcus, PRCV (PRCV), pig are numerousGrow the secondary with other respiratory tract bacteriums such as disordered breathing syndrome virus (PRRSV) and RespirovirusOr mixed infection, make epidemic situation more complicated, aggravation, the death rate increases, and the economy causing is thus damagedLose and cannot estimate especially.
At present, swine flu is without specific drug, and traditional Western medicine curative effect of medication of preventing and treating swine flu is general, this type ofMedicine, taking influenza virus stromatin as action target spot, stops virus uncoating by blocking-up M2 ion channel,Viral RNA can not be discharged in cytoplasm, and copying in early days of virus is suppressed, resists thereby play itInfluenza virus effect, but swine influenza virus strain can develop immunity to drugs to this class medicine of long-term use.
Chinese herbal medicine, as natural products, has medicine source abundant, and residual hazard is lower or without residual hazard, side effect is little,Be difficult for producing the advantages such as drug resistance; Can regulate body's immunity, suppress virus replication, improve and suffer from simultaneouslyDisease symptoms is widely used on control disease of viral infection. Therefore, application herbal control swine flu,Prospect is very wide, and the present invention is exactly the Chinese drug-treated group that swine flu prevented and treated in a kind of term of proposing on this basisCompound feed addictive and adopt the feed of this feed addictive, adopts this Chinese medicine composition to realize pig streamThe control that row sexuality is emitted.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing and treating the Chinese drug-treated group of swine influenzaCompound feed addictive and adopt the feed of this feed addictive, it is abundant that this Chinese medicine composition has medicine source,Residual hazard is lower or without residual hazard, side effect is little, is difficult for producing resistance, and it can regulate body's immunity, presses downVirus replication processed, improves illness symptom, has significant effect preventing and treating aspect swine influenza.
For solving the problems of the technologies described above, the invention provides a kind of for preventing and treating the Chinese medicine of swine influenzaComposition feed addictive, its bulk drug comprises dandelion, the coptis, Chinese ephedra, cassia twig, Morinda officinalis, whiteArt, Companumoea root, Gorgon fruit, the fruit of glossy privet, parasitic loranthus, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube,Saururus chinensis, leaf of negundo chastetree, the fruit of Chinese magnoliavine, kuh-seng, Radix Angelicae Sinensis, subprostrate sophora, pyrola, gynostemma pentaphylla and radix bupleuri.
Wherein, the weight of described each bulk drug is respectively dandelion 22g～32g, coptis 50g～60g, fiber cropsYellow 31g～41g, cassia twig 25g～35g, Morinda officinalis 30g～40g, bighead atractylodes rhizome 27g～37g, Companumoea root 30g～40g, Gorgon fruit 25g～35g, fruit of glossy privet 31g～41g, parasitic loranthus 23g～33g, Kaempferia galanga 19g～29g,Rose Mallow Root 20g～30g, milfoil 17g～27g, suchow mosla herb 26g～36g, horse sour jujube 25g～35g, three whiteGrass 19g～29g, leaf of negundo chastetree 20g～30g, fruit of Chinese magnoliavine 29g～39g, kuh-seng 23g～33g, Radix Angelicae Sinensis30g～40g, subprostrate sophora 25g～35g, pyrola 28g～38g, gynostemma pentaphylla 30g～40g and radix bupleuri25g～35g。
Wherein, the weight of described each bulk drug is respectively dandelion 25g～29g, coptis 53g～57g, fiber cropsYellow 34g～38g, cassia twig 28g～32g, Morinda officinalis 33g～37g, bighead atractylodes rhizome 30g～34g, Companumoea root 33g～37g, Gorgon fruit 28g～32g, fruit of glossy privet 34g～38g, parasitic loranthus 26g～30g, Kaempferia galanga 22g～26g,Rose Mallow Root 23g～27g, milfoil 20g～24g, suchow mosla herb 29g～33g, horse sour jujube 28g～32g, three whiteGrass 22g～26g, leaf of negundo chastetree 23g～27g, fruit of Chinese magnoliavine 32g～36g, kuh-seng 26g～30g, Radix Angelicae Sinensis33g～37g, subprostrate sophora 28g～32g, pyrola 31g～35g, gynostemma pentaphylla 33g～37g and radix bupleuri28g～32g。
Wherein, the weight of described each bulk drug is respectively dandelion 27g, coptis 55g, Chinese ephedra 36g, osmanthusBranch 30g, Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus28g, Kaempferia galanga 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g,Leaf of negundo chastetree 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, subprostrate sophora 30g, pyrola 33g,Gynostemma pentaphylla 35g and radix bupleuri 30g.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition feed addictive, is specially:
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb,Horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into mixer according to above-mentioned weightIn mix, mixture is packed in percolator, every 100g mixture adds the white wine of 50 DEG C～55 DEG C500g～700g soaks 20 hours～30 hours under the condition of 25 DEG C～35 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtains 700mL～1LPercolate, concentrated, remove white wine, dry, pulverize, obtain dry powder;
Second step, sends remaining component into stirrer for mixing even by weight, and every 100g mixture, addsEnter the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds againThe water of 200g～300g, boils 1～2 hour again, filters, and obtains the second filtrate, by the first filtrate andThe second filtrate is mixed, and the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition and raisesFeed additives.
It is a kind of for preventing and treating the feed of swine influenza that the present invention also provides, and its raw material comprises corn, beansThe dregs of rice, salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, vitamin A, vitaminE, ethoxyquinoline and above-mentioned for preventing and treating the Chinese medicine composition feed addictive of swine influenza.
Wherein, in described feed the weight portion of each raw material be respectively corn 280 weight portion～320 weight portions,Dregs of beans 140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portions～40 weight portions, soya-bean oil 20 weight portion～30 weight portions, zinc methionine 0.5 weight portion～1.5 weight portion,Copper lysinate 0.5 weight portion～1.5 weight portion, tryptophan 0.5 weight portion～1.5 weight portion, vitaminA1 weight portion～2 weight portion, vitamin e1 weight portion～2 weight portion, ethoxyquinoline 2 weight portions～4 weight portions, Chinese medicine composition feed addictive 30 weight portion～50 weight portions.
Further, in described feed, the weight portion of each raw material is respectively corn 300 weight portions, dregs of beans 150Weight portion, salt 4 weight portions, fish meal 35 weight portions, soya-bean oil 25 weight portions, zinc methionine 1 weightPart, Copper lysinate 1 weight portion, tryptophan 1 weight portion, dehydroretinol weight portion, vitamin E2Weight portion, ethoxyquinoline 3 weight portions, Chinese medicine composition feed addictive 40 weight portions.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares described Chinese medicine composition feed addictive;
Second step, raises the described Chinese medicine composition of other raw material components in feedstuff and first step acquisitionFeed additives is put into fodder mixing machine together, and continuous uniform stirred after 1～3 hour, put into pulverizerPulverize, obtain feed.
Beneficial effect of the present invention:
Provided by the invention for preventing and treating Chinese medicine composition feed addictive and the employing of swine influenzaIt is abundant that the feed of this feed addictive has medicine source, and residual hazard is lower or without residual hazard, side effect is little, is difficult for producingRaw resistance, it can regulate body's immunity, suppresses virus replication, improves illness symptom, control pigInfluenza aspect has significant effect.
Detailed description of the invention
The invention provides a kind of for preventing and treating the Chinese medicine composition feed addictive of swine influenza, itsBulk drug comprises dandelion, the coptis, Chinese ephedra, cassia twig, Morinda officinalis, the bighead atractylodes rhizome, Companumoea root, Gorgon fruit, femaleLoyal son, parasitic loranthus, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb, horse sour jujube, saururus chinensis, leaf of negundo chastetree, fiveTaste, kuh-seng, Radix Angelicae Sinensis, subprostrate sophora, pyrola, gynostemma pentaphylla and radix bupleuri.
Further, described Chinese medicine composition feed addictive is only made up of above-mentioned raw materials medicine.
The weight of described each bulk drug be respectively dandelion 22g～32g, coptis 50g～60g, Chinese ephedra 31g～41g, cassia twig 25g～35g, Morinda officinalis 30g～40g, bighead atractylodes rhizome 27g～37g, Companumoea root 30g～40g,Gorgon fruit 25g～35g, fruit of glossy privet 31g～41g, parasitic loranthus 23g～33g, Kaempferia galanga 19g～29g, peachFlower 20g～30g, milfoil 17g～27g, suchow mosla herb 26g～36g, horse sour jujube 25g～35g, saururus chinensis 19g～29g, leaf of negundo chastetree 20g～30g, fruit of Chinese magnoliavine 29g～39g, kuh-seng 23g～33g, Radix Angelicae Sinensis 30g～40g,Subprostrate sophora 25g～35g, pyrola 28g～38g, gynostemma pentaphylla 30g～40g and radix bupleuri 25g～35g.
Further preferably, the weight of described each bulk drug be respectively dandelion 25g～29g, coptis 53g～57g, Chinese ephedra 34g～38g, cassia twig 28g～32g, Morinda officinalis 33g～37g, bighead atractylodes rhizome 30g～34g, soilRadix Codonopsis 33g～37g, Gorgon fruit 28g～32g, fruit of glossy privet 34g～38g, parasitic loranthus 26g～30g, Kaempferia galanga22g～26g, Rose Mallow Root 23g～27g, milfoil 20g～24g, suchow mosla herb 29g～33g, horse sour jujube 28g～32g, saururus chinensis 22g～26g, leaf of negundo chastetree 23g～27g, fruit of Chinese magnoliavine 32g～36g, kuh-seng 26g～30g, Radix Angelicae Sinensis 33g～37g, subprostrate sophora 28g～32g, pyrola 31g～35g, gynostemma pentaphylla 33g～37gWith radix bupleuri 28g～32g.
Have most choosing, the weight of described each bulk drug be respectively dandelion 27g, coptis 55g, Chinese ephedra 36g,Cassia twig 30g, Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, mulberry are postedRaw 28g, Kaempferia galanga 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis24g, leaf of negundo chastetree 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, subprostrate sophora 30g, pyrola33g, gynostemma pentaphylla 35g and radix bupleuri 30g.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition feed addictive, is specially:
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb,Horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into mixer according to above-mentioned weightIn mix, mixture is packed in percolator, every 100g mixture adds the white wine of 50 DEG C～55 DEG C500g～700g soaks 20 hours～30 hours under the condition of 25 DEG C～35 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtains 700mL～1LPercolate, concentrated, remove white wine, dry, pulverize, obtain dry powder;
Second step, sends remaining component into stirrer for mixing even by weight, and every 100g mixture, addsEnter the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds againThe water of 200g～300g, boils 1～2 hour again, filters, and obtains the second filtrate, by the first filtrate andThe second filtrate is mixed, and the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition and raisesFeed additives.
Each bulk drug pharmacology is as follows:
Dandelion: latin name TaraxaciHerba, taste is sweet, bitter, cold in nature, enters liver, stomach warp, hasClearing heat and detoxicating, the carbuncle that disappears dissipating bind, clear liver and improve vision, the effect of inducing diuresis for treating strangurtia, be mainly used in the anti-of sore swollen toxinControl, especially remarkable to acute mastitis effect, also can be used for the cards such as the red eye, swell pain of liver-fire flaming.
The coptis: bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat solutionPoison, the effect of cooling blood for improving eyesight, is usually used in preventing and treating the fire of removing the heart-fire warp, the dysphoria and insomnia that internal heat is prosperous, and warmThe high fever coma of disease, the symptom such as vexed, thirsty.
Chinese ephedra: pungent, the micro-hardship of taste, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, freeing lung and relieving asthma,The effect of inducing diuresis for removing edema, is mainly used in the superficies excess syndromes such as the fever without perspiration of catching cold; Rheumatic numbness pain; ColdEvil criminal's lung or accumulation of heat in the lung are to coughing the cards such as contrary, oedema, difficult urination of breathing.
Cassia twig: latin name cinnamomiramulus is the dry spray of canella Chinese cassia tree: taste is pungent, sweet,Warm in nature, the thoughts of returning home, lung, urinary bladder channel, have sweating expelling pathogenic factors from muscles and skin, and warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop painEffect, warming meridians and promoting circulation of qi, horizontal logical podomere, for the illness that has not attacked the vital organs of the human body of catching cold, no matter have sweat, losslessly all can answerWith, also for arthralgia due to wind-dampness, stomach cold stomachache, through closing, dysmenorrhoea, arthralgia due to wind-dampness, shoulder arm podomere crymodynia etc.Card, phlegm retention syndrome and bladder retaining, the heart is insufficiency of the spleen-yang, retention of water-damp in the body, fullness in chest and hypochondrium, coughs the contrary dizzy phlegm retention syndrome that waits.
Morinda officinalis: taste is pungent, sweet, slightly warm in nature, enters liver, kidney channel, has kidney-replenishing, strengthening the bones and muscles, dispels the windWet effect, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen crymodynia, palace is cold infertile, due to kidney deficiency and liverThe card such as soft, the waist knee crymodynia of muscles and bones impotence.
The bighead atractylodes rhizome: latin name atractylodismacrocephalaerhizoma, bitter, sweet, warm in nature, enterSpleen, stomach warp, have strengthening the spleen and replenishing qi, eliminating dampness Li Shui, and hidroschesis, antiabortive effect, for weakness of the spleen and the stomach,The few turgor of food, lassitude hypodynamia, has loose bowels, water-damp retention, phlegm and retained fluid, oedema, the cards such as exterior deficiency spontaneous perspiration, haveAdjust gastrointestinal motility function, antiulcer, protect the liver, enhanced machine body immunity function, anti-ly stress, strengthen hematopoiesisThe effects such as function
Companumoea root: latin name radixcampanumoeajavanicae is Campanulaceae leopard platymisciumThe root of Campanumoea javanica and leopard, taste is sweet, and property is flat, returns lung, the spleen channel, has strengthening the spleen and replenishing qi, tonifying lungCough-relieving, effect of lactogenesis, cures mainly the empty internal injury of labor, and the deficiency of vital energy is weak, palpitaition, hidrosis, splenasthenic diarrhea is whiteBand, milk rareness, the cards such as insufficiency of the spleen cough.
Gorgon fruit: taste is sweet, puckery, property is flat, returns spleen, kidney channel. There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, clearing dampOnly the function of band, cures mainly emission, splenasthenic diarrhea, and insufficiency of the spleen gonorrhoea, is with inferior card.
The fruit of glossy privet: taste is sweet, bitter, is slightly cold, enters liver, kidney channel, has strong liver kidney-nourishing, the effect of removing heat to brighten vision,Be mainly used in preventing and treating liver-kidney Yin deficiency, the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat. Fruit of glossy privet energyPromote leucocyte, strengthen effect of immunologic function, have stronger to staphylococcus aureus, shigella dysenteriaeInhibitory action.
Parasitic loranthus: bitter, sweet, property is flat, enters liver, kidney channel, have filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic,The effect of antiabortive unit, for the soreness of waist pain due to kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, liver kidneyDeficiency, essence and blood is empty to be lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.
Kaempferia galanga: latin name kaempferiaerhizoma is the rhizome of Zingiber Kaempferia plant Kaempferia galanga, propertyTemperature, taste is pungent, returns stomach warp, has in temperature, helps digestion, and effect of pain relieving, cures mainly trusted subordinate's crymodynia, stopsDyspepsia, traumatic injury, toothache, the diet card such as do not disappear.
Rose Mallow Root: taste is sweet, light, property is flat, enters the heart, lung channel, has expelling wind and removing dampness, clearing heat and detoxicating meritEffect, cures mainly cold, fever, arthralgia due to wind-dampness, and dysentery, oedema, leukorrhea, spits blood, and carbuncle is swollen, traumatism and bleeding,Venomous snake bite, acute infantile convulsions, lockjaw, asthma, the cards such as stomachache cold after delivery.
Milfoil: taste is pungent; Bitter; Property flat temperature, there is wind-expelling pain-stopping; Effect of promoting blood circulation and detoxication, cures mainlyCold, fever; Wind pain; Toothache; Arthralgia due to wind-dampness; Blood stasis is through closing; Belly lump in the abdomen; Traumatic injury;Venomous snake bite; The cards such as carbuncle sore tumefacting virus.
Suchow mosla herb: warm in nature, taste is pungent, has dispelling summer-heat to relieve superficies syndrome, effect of regulating qi-flowing for relieving pain, cures mainly flu, inHeat, eruptive disease, peratodynia, the cards such as abscess of throat.
Horse sour jujube: bitter, puckery, property is flat, has clearing heat and detoxicatingly, and loose long-pending effect of stagnation resolvation, cures mainly wind-heat senseEmit cough with lung heat, furunculosis, acute mastitis, traumatic injury, dyspeptic abdominal distention, the cards such as venomous snake bite.
Saururus chinensis: latin name SaururiHerba, taste is sweet, pungent, cold in nature, returns lung, urinary bladder channel, hasHeat-clearing profit distilled water; Effect of removing toxicity for detumescence, cures mainly heat and drenches; Blood drenches; Distillation oedema; Beriberi;Jaundice; Dysentery; Under band; Carbuncle sore tumefacting virus; Eczema; The cards such as snake bite.
Leaf of negundo chastetree: latin name ViticisNegundoFolium, taste is pungent; Bitter; Property is put down, and returns lung channel, toolThere is the dampness elimination of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expels pathogenic wind from the body surface, dehumidifying, and desinsection, effect of pain relieving, cures mainlyCold, cough, asthma; Stomachache; Stomachache; Summer-heat and damp is rushed down dysentery; Beriberi swelling; Rubella itch; The ringworm of the foot;Acute mastitis swells and ache; The cards such as snake bite and insect sting.
The fruit of Chinese magnoliavine: warm in nature, taste acid, sweet, enters lung, the heart, kidney channel, has convergence astringent or styptic treatment for spontaneous sweating, nourishing generate fluid,The effect of kidney calming. Breathe heavily for the void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration,Night sweat, Tianjin wound is thirsty, the feeble pulse of losing heart, interior heat is quenched one's thirst, the cards such as palpitation and insomnia.
Kuh-seng: bitter, cold in nature, enter liver, kidney, large intestine, small intestine, bladder, the heart channel of Hang-Shaoyin, there is heat-clearing dryWet, effect of wind dispelling insecticide, cures mainly damp-heat dysentery, hematochezia, and jaundice, difficult urination, oedema,Under band, pruritus vulvae, mange, leprosy, pruitus, the cards such as eczema of lower limb ulcer.
Radix Angelicae Sinensis: taste is sweet, pungent, warm in nature, enters liver, the heart, the spleen channel, enriches blood and invigorates blood circulation, menstruction regulating and pain relieving, profitThe effect of intestines defaecation, is mainly used in having a dizzy spell of deficiency of heart-blood, lassitude hypodynamia, and palpitation, andHis syndrome of blood deficiency; Sea of blood inanition, the irregular menstruation of the cold and deficiency of chong and ren channels or extravasated blood retardance, dysmenorrhoea, produces or stomachache,And the symptom such as the constipation that other blood stasis are had a pain and the few intestines of deficiency of Yin blood are dry, its can improve uterus blood circulation,Alleviate pelvic congestion, the cards such as relieving dysmenorrhea.
Subprostrate sophora: bitter, cold in nature, enter the heart, lung, large intestine channel, there is removing toxic substances relieve sore throat, clearing heat and promoting diuresis,Effect that desinsection is anticancer, for abscess of throat, the gum dentalgia that swells, cough with lung heat, dysentery, jaundice,The cards such as the swollen favus of the scalp of heat, especially have good effect preventing and treating in the cancers such as nasopharyngeal carcinoma.
Pyrola: taste is sweet, bitter, warm in nature, enters lung channel, stomach warp, Liver Channel, kidney channel, can qi-restoratives, kidney-nourishing,Dispel rheumatism, promoting blood circulation for regulating menstruation, the strong bone of kidney tonifying, dispel rheumatism, cough-relieving, hemostasis, cure mainly main lumbago due to the kidney deficiency,Arthralgia due to wind-dampness, soft, the new chronic cough of muscles and bones impotence are coughed, haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatism and bleeding.
Gynostemma pentaphylla: another name seven leaf courages, Pentapanax leschenaultii, gynostemma pentaphyllum makino, Herba Gynostemmatis, the public arched end, Radix Rhodiolae,The sweet bitter edible plant is climing, southern ginseng, and cold in nature, bitter, returns lung, spleen, kidney channel, and useful gas, calms the nerves, hypotensiveEffect, for deficiency of vital energy and physically weak, weak breath is weak; Vexed insomnia; High blood pressure, Light-headedness; VirusHepatitis; Tumor in digestive tract; The cards such as chronic bronchitis, find gynostemma pentaphylla master through modern medicine studyWanting active ingredient is polysaccharide, flavonoids, saponins and microelement kind, and its effect is mainly to promote peopleBody fat class metabolism, nutrition human body cell have good detoxicating, relieving inflammation effect simultaneously.
Radix bupleuri: latin name bupleuriradix is the dry root of umbelliferae bupleurum or radix bupleuri scorzoneraefolii,Bitter, cold nature, returns liver, gallbladder channel, has to evacuate to bring down a fever, and rises effect of the easypro liver of sun, curing mainly flu and sending outHeat, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterus comes off, irregular menstruation etc.Card.
It is a kind of for preventing and treating the feed of swine influenza that the present invention also provides, and its raw material comprises corn, beansThe dregs of rice, salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, vitamin A, vitaminE, ethoxyquinoline and above-mentioned for preventing and treating the Chinese medicine composition feed addictive of swine influenza.
Further, described feed is only made up of above-mentioned raw materials.
Further, in described feed, the weight portion of each raw material is respectively corn 280 weight portion～320 weightPart, dregs of beans 140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weightPart～40 weight portions, soya-bean oil 20 weight portion～30 weight portions, zinc methionine 0.5 weight portion～1.5 weightPart, Copper lysinate 0.5 weight portion～1.5 weight portion, tryptophan 0.5 weight portion～1.5 weight portion, support one's familyElement A1 weight portion～2 weight portion, vitamin e1 weight portion～2 weight portion, ethoxyquinoline 2 weightPart～4 weight portions, Chinese medicine composition feed addictive 30 weight portion～50 weight portions.
Further, in described feed, the weight portion of each raw material is respectively corn 300 weight portions, dregs of beans 150Weight portion, salt 4 weight portions, fish meal 35 weight portions, soya-bean oil 25 weight portions, zinc methionine 1 weightPart, Copper lysinate 1 weight portion, tryptophan 1 weight portion, dehydroretinol weight portion, vitamin E2Weight portion, ethoxyquinoline 3 weight portions, Chinese medicine composition feed addictive 40 weight portions.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares described Chinese medicine composition feed addictive;
Second step, raises the described Chinese medicine composition of other raw material components in feedstuff and first step acquisitionFeed additives is put into fodder mixing machine together, and continuous uniform stirred after 1～3 hour, put into pulverizerPulverize, obtain feed.
Below adopt embodiment to describe embodiments of the present invention in detail, whereby how the present invention is appliedTechnological means solves technical problem, and the implementation procedure of reaching technique effect can fully understand and real according to thisExecute.
Embodiment 1 Chinese medicine composition feed addictive 1
By dandelion 27g, coptis 55g, Chinese ephedra 36g, cassia twig 30g, Kaempferia galanga 24g, Rose Mallow Root 25g,Milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g, subprostrate sophora 30g, pyrola 33g andRadix bupleuri 30g pulverizes respectively, sends into stirrer for mixing even, mixture is packed in percolator into every 100gMixture adds the white wine 600g of 55 DEG C, soaks 25 hours under the condition of 30 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 3mL per minute, collects drip, obtains oozing of 800mlThe liquid of filtering, concentrated, remove white wine, dry, pulverize, obtain dry powder, by Morinda officinalis 35g, whiteArt 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus 28g, leaf of negundo chastetree 25g, fiveTaste 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, that gynostemma pentaphylla 35g sends into stirrer for mixing is even, every 100gMixture, adds the water of 600g, boils 4 hours, filters, and obtains the first filtrate, and filter residue adds againThe water of 300g, boils 2 hours again, filters, and obtains the second filtrate, by the first filtrate and the second filtrateMix, the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder, dry by what obtain abovePowder mix, obtain Chinese medicine composition feed addictive 1.
Embodiment 2 Chinese medicine composition feed addictives 2
By dandelion 25g, coptis 53g, Chinese ephedra 34g, cassia twig 28g, Kaempferia galanga 22g, Rose Mallow Root 23g,Milfoil 20g, suchow mosla herb 29g, horse sour jujube 28g, saururus chinensis 22g, subprostrate sophora 28g, pyrola 31g andRadix bupleuri 28g pulverizes respectively, sends into stirrer for mixing even, mixture is packed in percolator into every 100gMixture adds the white wine 600g of 55 DEG C, soaks 25 hours under the condition of 30 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 3mL per minute, collects drip, obtains oozing of 800mlThe liquid of filtering, concentrated, remove white wine, dry, pulverize, obtain dry powder, by Morinda officinalis 33g, whiteArt 30g, Companumoea root 33g, Gorgon fruit 28g, fruit of glossy privet 34g, parasitic loranthus 26g, leaf of negundo chastetree 23g, fiveTaste 32g, kuh-seng 26g, Radix Angelicae Sinensis 33g, that gynostemma pentaphylla 33g sends into stirrer for mixing is even, every 100gMixture, adds the water of 600g, boils 4 hours, filters, and obtains the first filtrate, and filter residue adds againThe water of 300g, boils 2 hours again, filters, and obtains the second filtrate, by the first filtrate and the second filtrateMix, the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder, dry by what obtain abovePowder mix, obtain Chinese medicine composition feed addictive 2.
Embodiment 3 Chinese medicine composition feed addictives 3
By dandelion 29g, coptis 57g, Chinese ephedra 38g, cassia twig 32g, Kaempferia galanga 26g, Rose Mallow Root 27g,Milfoil 24g, suchow mosla herb 33g, horse sour jujube 32g, saururus chinensis 26g, subprostrate sophora 32g, pyrola 35g andRadix bupleuri 32g pulverizes respectively, sends into stirrer for mixing even, mixture is packed in percolator into every 100gMixture adds the white wine 600g of 55 DEG C, soaks 25 hours under the condition of 30 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 3mL per minute, collects drip, obtains oozing of 800mlThe liquid of filtering, concentrated, remove white wine, dry, pulverize, obtain dry powder, by Morinda officinalis 37g, whiteArt 34g, Companumoea root 37g, Gorgon fruit 32g, fruit of glossy privet 38g, parasitic loranthus 30g, leaf of negundo chastetree 27g, the five tastesSub-36g, kuh-seng 30g, Radix Angelicae Sinensis 37g, that gynostemma pentaphylla 37g sends into stirrer for mixing is even, every 100gMixture, adds the water of 600g, boils 4 hours, filters, and obtains the first filtrate, and filter residue adds againThe water of 300g, boils 2 hours again, filters, and obtains the second filtrate, by the first filtrate and the second filtrateMix, the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder, dry by what obtain abovePowder mix, obtain Chinese medicine composition feed addictive 3.
Embodiment 4 toxicology tests
Acute toxicity testing
Select 20 of Kunming mouses, female half and half, body weight (20+2) g, in Qingdao City animal used as testThe heart provides, and Chinese medicine composition additive prepared by embodiment 1 is dissolved in distilled water, is prepared into 1g/mlSolution, gavage mouse, through preliminary experiment, fail to detect the LD of oral administration50Therefore, survey its maximumDosis tolerata, with the administration volume of 2.0ml/10g body weight, gavages 2 times/d, and interval 6h gives observation post administration7d, records animal dead and toxicity symptom, when experiment finishes, by all animals processing, dissects,Visually observe each main organs lesion tissue situation, gavage for 2 times after 140g crude drug/kg, animal activity,Feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the bright of main organs tissueAobvious abnormal.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, is carried by Qingdao City's Experimental Animal CenterConfession, is divided into 2 groups at random, blank group and Chinese drug-treated group, and 20 every group, blank group is distilledWater, the Chinese medicine composition additive that Chinese drug-treated group is prepared embodiment 1 is dissolved in distilled water, is prepared intoThe solution of 1g/ml, gavages rat, and the amount of gavaging is 50g crude drug/kg, on every Mondays to the morning Saturday gavage giveMedicine 1 time, continuously 180d, administration volume is 2mL/100g body weight, see every day before administration and during administrationExamine rat general state, sign, food ration, drinking-water and ight soil situation. When administration 90d in last administrationAfter 24h, each group extracts 6, male and female half and half; When 180d, after last administration 24h, each group extracts 6,Male and female half and half; After drug withdrawal, 30d respectively organizes and extracts 6, and male and female half and half, with urethane anesthesia, from belly masterArterial blood extracting, each group is all killed and gets animal, checks hematology and blood parameters, gets after blood, amasses wealth by heavy taxation at onceCore, liver,kidney,spleen, lung, adrenal gland, thyroid gland, thymus gland, testis, ovary, uterus, brain,The internal organs such as prostate are weighed, according to weight calculator official weight coefficient and make pathological examination.
On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair lightPool degree no abnormality seen, it is dead that animal has no, and naked eyes have no obvious pathology, respectively organize the inspection of rat peripheral hemogramLook into all in normal range (NR), the raw tea index of blood is all in normal range (NR), and Chinese drug-treated group Rats Organs and Tissues coefficient is with blankControl group is compared does not have significant difference.
Embodiment 5 feeds
By corn 300kg, dregs of beans 150kg, salt 4kg, fish meal 35kg, soya-bean oil 25kg, egg ammoniaAcid zinc 1kg, Copper lysinate 1kg, tryptophan 1kg, dehydroretinol kg, vitamin E2 kg, secondChinese medicine composition feed addictive 40kg prepared by phenoxyl quinoline 3kg, embodiment 1 puts into feed togetherIn mixer, continuous uniform stirred after 3 hours, put into pulverizer and pulverized, and obtained feed.
Embodiment 6 effect tests
Material
A/swine/Hebei/012/2008 (H9N2), real by Hebei North University's animal virus molecular biologyTest chamber and provide and separate preservation, go down to posterity through 10 age in days chick embryo allantoic cavity inoculated and cultured, Microhemagglutination test is drippedDetermine virus titer, tiring is 1: 256; The SPF level BALB/c small white mouse in 6～8 week age, body weight 18～22g, male and female half and half, Chinese medicine composition feed addictive 1 prepared by embodiment 1, ribavirin granule(Ribavirin), be purchased from Hua Shengtang bio tech ltd, Beijing.
Experimental design
Experimental animal is divided into Normal group, infection model group (infected pigs's not administration of influenza virus), profitBa Weilin group (10mg/kgd), Chinese medicine composition group (400mg/kgd), all in mouse infection influenza diseaseAdministration after poison.
Infection method
With the slight anesthetized mice of ether, Normal group is with physiological saline collunarium, every 50 μ l, all the otherEach group with 50 μ lH9N2 strain virus drop noses, and wherein in dead protection test, infective dose is 25LD50，Other experimental infection amounts are 1/3LD50。
Medication
Chinese medicine composition feed addictive prepared by embodiment 1 is dissolved in water, is heated to dissolve completely,Filter, be concentrated into 1g/ml, mouse stomach administration after infection 4h, each 0.2ml, every day 2 times, connectsContinuous 5d, normal blank group, infection model group gavage physiological saline 0.2ml.
The LD of H9N250Mensuration
By influenza virus stock solution (chick embryo allantoic liquid) doubling dilution of collecting, obtain 10-1、10-2、10-3、10-4、10-5The virus liquid of concentration. Get 48 of mouse, be divided into 6 groups with random sampling, ether is lightAfter degree anesthesia, collunarium infects different dilution factor virus liquid 0.05ml, taking dead and existence as observation index, and 24Dead will not adding up in h. Observe every day, until infect latter the 14th day. Calculate half of virusNumber lethal dose (LD50)。
To the test of the dead protection of H9N2 infecting mouse
Infect according to infection method above-mentioned, administration 5d observes animal disease symptom, record day by dayDeath time, death toll, observes 14d altogether, is calculated as follows result: dead protective rate (%)=(infect mouldThe type group death rate-test group death rate)/infection model group the death rate × 100; Extending life rate (%)=(testThe average survival of group number of days-infection model group number of days of on average surviving)/infection model group on average survive number of days ×100。
Lung index, lung index and lung suspension viral hemoagglutination titer determination
After mouse medication the 5th day, first fasting water 8h, plucked eyeball sacrificed by exsanguination mouse after weighing, openThoracic cavity extracts full lung, and with physiological saline washing 2 times, filter paper blots surperficial moisture content, claims lung weight, by followingFormula calculates lung exponential sum lung index: lung index=(mouse lung weight/Mouse Weight) × 100%; LungIndex inhibiting rate=(the average lung index of the average lung index-experimental group of infection model group)/infection model group is averageLung index × 100%. With adding physiological saline [lung heavy (g): physiological saline (ml)=1: 9] in rearmounted homogenizer,Homogenate is made in grinding, and centrifugal (4 DEG C, 2500rpm × 30min) are got supernatant and carried out according to a conventional method Trace BloodSolidifying test.
Index and spleen index and thymus index are measured
After mouse medication the 5th day, fasting water 8h, plucked eyeball sacrificed by exsanguination mouse after weighing, extraction spleenDirty and thymus gland, physiological saline washing 2 times, filter paper blots surperficial moisture content, claims lung weight, by following formula byIndividual calculating index and spleen index: index and spleen index=(mice spleen weight/Mouse Weight) × 100%; Thymus index=(mouse chestGland weight/Mouse Weight) × 100%.
Data processing
Measurement data adoptsRepresent, between group, relatively adopt χ2Inspection, all data all adoptThe processing of SPSS12.0 statistical software.
Results and analysis
The LD of H9N250
Mouse infection the 3rd day, all there is disease symptom in various degree in front 3 groups of mouse: lassitude, send outTremble, pant, degradation under diet; Within the 5th day, infecting mouse starts to occur walking pendulous symptom; The 6thIt the 1st group
The highest viral level group mouse starts to occur dead, and all the other each group in infecting the rear the 8th
It occurs dead successively. Observe altogether 14d, add up each group of dead mouse number (table 1). Calculate this streamThe LD of Influenza Virus50Be 2.49. Distance proportion=(higher than 50% accumulative total per cent death loss-50%)/(higher than 50%Accumulative total per cent death loss-lower than 50% accumulative total per cent death loss)=85.71-50/85.71-14.28=0.49.
Median lethal dose (the LD of table 1H9N2 Strain50) calculate
| Dilution factor | Death toll | Dead accumulative total | Survival accumulative total | Dead ratio | Dead accumulative total rate/% |
| 10-1 | 8 | 20 | 0 | 20/20 | 100.0 |
| 10-2 | 6 | 12 | 2 | 12/14 | 85.7 |
| 10-3 | 4 | 6 | 6 | 6/12 | 50.0 |
| 10-4 | 2 | 2 | 12 | 2/14 | 14.3 |
| 10-5 | 0 | 0 | 20 | 0/20 | 0 |
The death protection result of Chinese medicine composition feed addictive to H9N2 virus infected mice, the results are shown inTable 2.
The death protection result of table 2 Chinese medicine composition feed addictive to H9N2 virus infected mice
Chinese medicine composition group and Ribavirin group are compared with infection model group, and the death rate obviously reduces (P <0.01), the mean survival time of mouse obviously extends (P < 0.01) (table 2), and visible Chinese medicine composition can haveThe pathogenic effects of effect antagonism swine influenza virus.
Chinese medicine composition is to blood in swine influenza virus Lung Index of mice infected by Influenza virus, lung index and lung tissueThe impact of solidifying titre, the results are shown in Table 3.
Table 3 Chinese medicine composition is to swine influenza virus Lung Index of mice infected by Influenza virus, lung index and lung tissueThe impact of middle blood clotting titre
Lung index result shows: the blank group of infection model group compared with normal lung index obviously raises, and difference is extremely aobviousWork (P < 0.01); Chinese medicine composition group and Ribavirin are prevented and treated group and are reduced (P < compared with infection model group lung index0.01), Chinese drug-treated group and Ribavirin group are without significant difference.
The impact of Chinese medicine composition on swine influenza virus infecting mouse index and spleen index and thymus index, the results are shown inTable 4.
The impact of table 4 Chinese medicine composition on swine influenza virus infecting mouse index and spleen index and thymus index
As shown in Table 4, after pig virus infected mice, infection model group index and spleen index reduces, with normal skyRelatively, difference is (P < 0.01) extremely significantly for white group; Ribavirin group and the comparison of infection model group, there were significant differences(P < 0.05); After swine influenza virus infecting mouse, infection model group thymus index reduces, with normal blankGroup relatively, has utmost point significant difference (P < 0.01); Compound Chinese medicinal preparation group and Ribavirin group thymus index are feltDye model group and increase, difference is (P < 0.01) extremely significantly.
All above-mentioned these intellectual properties of primary enforcement, do not set the other forms of enforcement of restriction thisPlant new product and/or new method. Those skilled in the art will utilize this important information, foregoing amendment,To realize similar implementation status. But all modifications or transformation belong to reservation based on new product of the present inventionRight.
The above, be only preferred embodiment of the present invention, is not that the present invention is made to other formRestriction, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changedOr be modified as the equivalent embodiment of equivalent variations. But every technical solution of the present invention content that do not depart from, complies withAny simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention,Still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. for preventing and treating the feed of swine influenza, it is characterized in that: raw material comprise corn, dregs of beans,Salt, fish meal, soya-bean oil, zinc methionine, Copper lysinate, tryptophan, VitAVitE,Ethoxyquinoline and for preventing and treating the Chinese medicine composition feed addictive of swine influenza;
The bulk drug of described Chinese medicine composition feed addictive is by dandelion, the coptis, Chinese ephedra, cassia twig, barHalberd sky, the bighead atractylodes rhizome, Companumoea root, Gorgon fruit, the fruit of glossy privet, parasitic loranthus, Kaempferia galanga, Rose Mallow Root, milfoil, spicesGrass, horse sour jujube, saururus chinensis, leaf of negundo chastetree, the fruit of Chinese magnoliavine, kuh-seng, Radix Angelicae Sinensis, subprostrate sophora, pyrola, strandBlue and radix bupleuri forms;
The weight of each bulk drug of described Chinese medicine composition feed addictive be respectively dandelion 22g～32g,Coptis 50g～60g, Chinese ephedra 31g～41g, cassia twig 25g～35g, Morinda officinalis 30g～40g, bighead atractylodes rhizome 27g～37g, Companumoea root 30g～40g, Gorgon fruit 25g～35g, fruit of glossy privet 31g～41g, parasitic loranthus 23g～33g,Kaempferia galanga 19g～29g, Rose Mallow Root 20g～30g, milfoil 17g～27g, suchow mosla herb 26g～36g, horse sour jujube25g～35g, saururus chinensis 19g～29g, leaf of negundo chastetree 20g～30g, fruit of Chinese magnoliavine 29g～39g, kuh-seng23g～33g, Radix Angelicae Sinensis 30g～40g, subprostrate sophora 25g～35g, pyrola 28g～38g, gynostemma pentaphylla30g～40g and radix bupleuri 25g～35g;
In described feed, the weight portion of each raw material is respectively corn 280 weight portion～320 weight portions, dregs of beans140 weight portion～160 weight portions, salt 3 weight portion～5 weight portions, fish meal 30 weight portion～40 weightsAmount part, soya-bean oil 20 weight portion～30 weight portions, zinc methionine 0.5 weight portion～1.5 weight portion, bad ammoniaAcid copper 0.5 weight portion～1.5 weight portion, tryptophan 0.5 weight portion～1.5 weight portion, retinol1 weightAmount part～2 weight portions, vitamin e1 weight portion～2 weight portion, ethoxyquinoline 2 weight portion～4 weightsAmount part, Chinese medicine composition feed addictive 30 weight portion～50 weight portions.
2. feed as claimed in claim 1, is characterized in that: the weight portion of each raw material in described feedBe respectively corn 300 weight portions, dregs of beans 150 weight portions, salt 4 weight portions, fish meal 35 weight portions,Soya-bean oil 25 weight portions, zinc methionine 1 weight portion, Copper lysinate 1 weight portion, tryptophan 1 weight portion,Dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portions, Chinese medicine compositionFeed addictive 40 weight portions.
3. feed as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition feed addsThe weight that adds each bulk drug of agent be respectively dandelion 25g～29g, coptis 53g～57g, Chinese ephedra 34g～38g, cassia twig 28g～32g, Morinda officinalis 33g～37g, bighead atractylodes rhizome 30g～34g, Companumoea root 33g～37g,Gorgon fruit 28g～32g, fruit of glossy privet 34g～38g, parasitic loranthus 26g～30g, Kaempferia galanga 22g～26g, peachFlower 23g～27g, milfoil 20g～24g, suchow mosla herb 29g～33g, horse sour jujube 28g～32g, saururus chinensis 22g～26g, leaf of negundo chastetree 23g～27g, fruit of Chinese magnoliavine 32g～36g, kuh-seng 26g～30g, Radix Angelicae Sinensis 33g～37g,Subprostrate sophora 28g～32g, pyrola 31g～35g, gynostemma pentaphylla 33g～37g and radix bupleuri 28g～32g.
4. feed as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition feed addsThe weight that adds each bulk drug of agent be respectively dandelion 27g, coptis 55g, Chinese ephedra 36g, cassia twig 30g,Morinda officinalis 35g, bighead atractylodes rhizome 32g, Companumoea root 35g, Gorgon fruit 30g, fruit of glossy privet 36g, parasitic loranthus 28g, mountainA kind of apple 24g, Rose Mallow Root 25g, milfoil 22g, suchow mosla herb 31g, horse sour jujube 30g, saururus chinensis 24g, Vitex negundo var cannabifoliaLeaf 25g, fruit of Chinese magnoliavine 34g, kuh-seng 28g, Radix Angelicae Sinensis 35g, subprostrate sophora 30g, pyrola 33g, strandBlue 35g and radix bupleuri 30g.
5. feed as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition feed addsThe preparation method who adds agent, comprises,
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb,Horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into mixer according to above-mentioned weightIn mix, mixture is packed in percolator, every 100g mixture adds the white wine of 50 DEG C～55 DEG C500g～700g soaks 20 hours～30 hours under the condition of 25 DEG C～35 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtains 700mL～1LPercolate, concentrated, remove white wine, dry, pulverize, obtain dry powder;
Second step, sends remaining component into stirrer for mixing even by weight, and every 100g mixture, addsEnter the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds againThe water of 200g～300g, boils 1～2 hour again, filters, and obtains the second filtrate, by the first filtrate andThe second filtrate is mixed, and the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition and raisesFeed additives.
6. the preparation method of feed described in claim 1 or 2, is characterized in that, comprising:
The first step, by dandelion, the coptis, Chinese ephedra, cassia twig, Kaempferia galanga, Rose Mallow Root, milfoil, suchow mosla herb,Horse sour jujube, saururus chinensis, subprostrate sophora, pyrola and radix bupleuri are pulverized respectively, send into mixer according to above-mentioned weightIn mix, mixture is packed in percolator, every 100g mixture adds the white wine of 50 DEG C～55 DEG C500g～700g soaks 20 hours～30 hours under the condition of 25 DEG C～35 DEG C, regulates percolator valve,White wine liquid is slowly oozed, and the speed of oozing is 2～4mL per minute, collects drip, obtains 700mL～1LPercolate, concentrated, remove white wine, dry, pulverize, obtain dry powder;
Second step, sends remaining component into stirrer for mixing even by weight, and every 100g mixture, addsEnter the water of 500g～600g, boil 3～4 hours, filter, obtain the first filtrate, filter residue adds againThe water of 200g～300g, boils 1～2 hour again, filters, and obtains the second filtrate, by the first filtrate andThe second filtrate is mixed, and the concentrated aqueous solvent of removing, pulverizes, dry, obtains dry powder;
The 3rd step, mixes the dry powder of the first step and second step acquisition, obtains Chinese medicine composition and raisesFeed additives;
The 4th step, raises the described Chinese medicine composition of other raw material components in feedstuff and the acquisition of the 3rd stepFeed additives is put into fodder mixing machine together, and continuous uniform stirred after 1～3 hour, put into pulverizerPulverize, obtain feed.
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|---|---|---|---|---|
| CN101120732A (en) * | 2007-09-07 | 2008-02-13 | 济南和美华饲料有限公司 | Feed for promoting nursery pig immunity |
| CN102772492A (en) * | 2012-06-30 | 2012-11-14 | 王志坚 | Traditional Chinese medicine feed additive for preventing and treating swine influenza |
| CN103750060A (en) * | 2014-01-27 | 2014-04-30 | 山东新希望六和集团有限公司 | Feed for treating pig influenza and preparation method thereof |
-
2014
- 2014-05-28 CN CN201410230988.0A patent/CN104082538B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120732A (en) * | 2007-09-07 | 2008-02-13 | 济南和美华饲料有限公司 | Feed for promoting nursery pig immunity |
| CN102772492A (en) * | 2012-06-30 | 2012-11-14 | 王志坚 | Traditional Chinese medicine feed additive for preventing and treating swine influenza |
| CN103750060A (en) * | 2014-01-27 | 2014-04-30 | 山东新希望六和集团有限公司 | Feed for treating pig influenza and preparation method thereof |
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|---|---|
| CN104082538A (en) | 2014-10-08 |
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