CN103417911A - Traditional Chinese medicine composition for supporting chemo-treatment - Google Patents
Traditional Chinese medicine composition for supporting chemo-treatment Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for supporting chemo-treatment. The composition comprises the following components: pangolin scales, membranous milkvetch root, curcuma aromatica, grape leaf, ginseng, radix linderae, giant knotweed, calculus bovis, laminaria, nostoc commune, cactus, pearl, realgar, croci stigma, centipede, bittersweet herb, trichosanthes root, black nightshade, radix rehmanniae recen, verbena, white paeony root, ganoderma, rhizome sparganii, fructus evodiae, puccoon, andrographis paniculata, deerhorn glue, bulb of edible tulip, daphne giraldii nitsche, and ramie root. The composition provided by the invention has the advantages of quick curative effect, high efficiency and small side effect aiming to the side effects caused by chemo-treatment.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition that is used for the treatment of the side effect that chemotherapy causes.
Background technology
Effective treatment of tumor is mainly still operation, chemotherapy, radiotherapy so far, yet, there is 80% patient will pass through chemotherapy, the existence of radiotherapy acquisition longer time.Yet chemotherapy cause as toxicities such as bone marrow transplantation, hypoimmunity, gastrointestinal reactions, make the patient be difficult to adhere to.The General Symptoms that chemotherapeutics causes comprises dizziness, fatigue and weak, lethargy, is off one's feed, insomnia and dreamful sleep, dry mouth and lack of saliva, defecation imbalance etc.As be aided with treatment by Chinese herbs and can increase curative effect, can avoid to a certain extent or alleviate again the toxicity of chemicotherapy, extend patient's life cycle and life quality.Existing Chinese medicinal formulae is mainly nursed one's health above-mentioned side effect by following four aspects: 1. the replenishing essence of enriching blood: 2. QI invigorating consolidates, and improves immunity: 3. regulating the stomach and sending down the abnormal ascending QI: alleviate the gastrointestinal reactions such as nauseating, vomiting; 4. tonifying speen and tonifying kidney.Above-mentioned side effect also can be summarized as 4 large classes: 1. digestive tract reaction: the gastrointestinal mucosal cell often is subject to the damage of Treated with Chemotherapeutic Drugs thing, causes a series of digestive tract reaction, the morning generally occurred than bone marrow depression.As: loss of appetite, nausea and vomiting, abdominal pain diarrhea etc. are that taste are become estranged, the performance of disorder in ascending and descending, and Chinese traditional treatment mainly be take invigorating the spleen and regulating the stomach, sending down the abnormal ascending QI emesis as main, and medicine has: Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Caulis Bambusae In Taenia etc.2. bone marrow depression: most antitumor drug all can cause bone marrow depression in various degree, and the decline that main manifestations is peripheral blood leucocyte, drop to the master with neutrophilic granulocyte, and some medicines descend obviously platelet.In more serious situation, can give granulocyte colony-stimulating factor, but the bone marrow depression recondition slowly the patient add the time of recovering with shortening hemogram after treatment by Chinese herbs.Medicine: Fructus Ligustri Lucidi, Fructus Corni etc.3. immunosuppressant: the immunoreation calibration ordinary person of late tumor patient is low, and most antitumor drug has impact in various degree to the immune state of body.Tumor, body's immunity state and Drug therapy interphase interaction are very complicated.Medicine has suppressed the immunologic function of body in killing off tumor cells, and the latter provides condition for the diffusion of tumor cell again.So both protected immunologic function and the resistance against diseases of body with the Chinese medicine adjustment, the growth that has suppressed to a certain extent tumor arranged.4. nerve injury: there is neurotoxicity in the medicine of some plant bases.As vincristine, paclitaxel, can cause that numb limbs and tense tendons, general weakness, knee jerk are low, enteroparalysis, constipation, ataxia etc.Treatment is commonly used: Caulis Trachelospermi, Caulis Spatholobi etc.
In order to slow down or to eliminate above-mentioned side effect, treat with Chinese medicine the side effect that chemotherapy causes and obtained certain effect, but still need more effective prescription, fast meeting curative effect, effective percentage is high, the demand that side effect is little.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine composition that is used for the treatment of the side effect that chemotherapy causes and preparation method thereof, adopt this Chinese medicine composition to there is curative effect to the treatment of the side effect that is used for the treatment of chemotherapy and causes fast, effective percentage is high, the advantages such as demand that side effect is little.
In order to solve the problems of the technologies described above; the invention provides a kind of Chinese medicine composition that is used for the treatment of the side effect that chemotherapy causes; it comprises: Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae.
Wherein, the ratio of weight and number of various components is, Squama Manis 10-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-25 weight portion, Radix Ginseng 5-20 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-20 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-20 weight portion, Scolopendra 10-15 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 10-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-25 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-20 weight portion, Herba Andrographis 10-20 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
Wherein, described Chinese medicine composition dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the above-mentioned Chinese medicine composition of different dosage form:
The preparation method of powder: after taking raw material, crude drug and pulverizing, sieve, fully mix and make powder.
The preparation method of granule: the first step, each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, add the water with respect to 2～4 times of mixture qualities, decoct and process 1～3 hour, decoction liquor is filtered, concentration, obtain the mastic of removing moisture, the ethanol that is 65%～75% by the determining alcohol that adds in the mastic of acquisition with respect to 3～5 times of first step mixture qualities, stirred 20 minutes～40 minutes, 0～4 ℃ of lower cold preservation 1～2 hour, filter, decompression recycling ethanol, obtain and get dry extract, dry, be ground into 20 orders～200 purpose powder, obtain the Chinese medicine composition additive granules.
The preparation method of powder: each component in described Chinese medicine composition additive is mixed in proportion, obtains mixture, after the crude drug mixture is pulverized, after first with ethanol, medical material being soaked to 2 hours, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue is used water extraction 2 times again, extracts for the first time 2.5 hours, extracts for the second time 1.5 hours, filters, and merging filtrate also is condensed into the thick paste shape; Merge extractum, finally add appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, dry, and pulverizes, and is prepared into powder.
Decoction preparation method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after the crude drug mixture is pulverized, after water soaks 1-2 hour by medical material, then decoct to boiling with high heat, then use slow fire boiling 30 minutes, filter, filtering residue adds slow fire boiling twice for water, each 1 hour.Merging filtrate, adding ethanol to ethanol content in filtrate after filtrate is concentrated is 70%, filter, filtrate recycling ethanol, concentrated, filtration, embedding, sterilizing, be prepared into oral liquid.
Injection preparation method: each component in described Chinese medicine composition additive is mixed in proportion, obtain mixture, after the crude drug mixture is pulverized, after water soaks 1-2 hour by medical material, then decoct to boiling with fire, then decoct 30 minutes with little fire, filter, filtering residue decocts twice, each 1 hour with little fire.Merging filtrate, adding ethanol to ethanol content in filtrate after filtrate is concentrated is 70%, filter, filtrate recycling ethanol, concentrated, cold preservation, filtration, fine straining, embedding, sterilizing, be prepared into injection.
For solving the problems of the technologies described above, the present invention also provides the above-mentioned application of Chinese medicine composition in the medicine of the side effect caused for the preparation of the treatment chemotherapy.
Beneficial effect of the present invention:
With respect to the medicine that is used for the treatment of the side effect that chemotherapy causes of the prior art, the advantage such as it is fast that the treatment of the side effect that adopts this Chinese medicine composition to cause chemotherapy has curative effect, and effective percentage is high, and side effect is little.
The specific embodiment
The invention provides a kind of Chinese medicine composition that is used for the treatment of the side effect that chemotherapy causes; it comprises: Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae.
Squama Manis, nature and flavor are salty, cool, enter liver, stomach warp, and function cures mainly, and the routed carbuncle of detumescence, search wind active, the stimulating milk secretion of stimulating the menstrual flow.Control carbuncle skin ulcer kind, anemofrigid-damp arthralgia, amenorrhea, galactostasis.The external hemostasis.
The Radix Astragali, warm in nature, sweet in the mouth.Function cures mainly: invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.For weak, the chronic diarrhea proctoptosis of the deficiency of vital energy, spontaneous perspiration, edema, sub-official's prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.
Radix Curcumae, the acrid in the mouth hardship, cool.Enter the heart, lung, Liver Channel.Function cures mainly: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, the calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
The compound leaf grape leaf, sweet in the mouth; Micro-puckery; Cool in nature, another name, ' Zhixueling; Sweet tea, effect: hemostasis; Clearing away summer-heat cures mainly: traumatic hemorrhage; The prevention heatstroke.
Radix Ginseng,, sweet and slightly bitter taste, temperature., spleen, lung meridian.Function cures mainly: strongly invigorating primordial QI, Gu de-, promote the production of body fluid, and calm the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
The Radix Linderae, property suffering, temperature.Enter spleen, lung, kidney, urinary bladder channel.Function cures mainly: pleasant, and dissipating depression of QI, cold expelling, pain relieving.Control the QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
Rhizoma Polygoni Cuspidati, nature and flavor, hardship, flat.Function cures mainly: dispels the wind, and dampness removing, removing blood stasis with potent drugs, stimulate the menstrual flow.The dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, the stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, hundred abdominal masss are gathered, the anal fistula hematochezia.Injury from falling down, scald malignant boil tinea disease.
Calculus Bovis, the property bitter but sweet flavor is cool.Enter the heart, Liver Channel.Function cures mainly: clears away heart-fire, reduces phlegm, and function of gallbladder promoting, relieving convulsion.Control calentura coma, delirium, epilepsy is gone mad, and infantile convulsion is twitched, ulcerative gingivitis, and larynx is swollen, aphtha of the mouth and tongue, carbuncle, furunculosis.
Thallus Laminariae (Thallus Eckloniae), nature and flavor are salty, cold.Function cures mainly: softening and eliminating sputum, diuretic expels the heat-evil.Control goiter tuberculosis, hernia abdominal mass, edema, beriberi.
Herba Hyperici Japonici, nature and flavor, bitter sweet, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Control infectious hepatitis, dysentery, infantile convulsion, infantile malnutrition, throat moth, acute appendicitis, furuncle and phyma, venom.
Radix et Caulis Opuntiae Dillenii, the nature and flavor hardship, cold.Enter the heart, lung, stomach three warps.Function cures mainly: promoting flow of QI and blood, heat-clearing and toxic substances removing.Control heart peratodynia, mass in the abdomen, dysentery, hemorrhoidal bleeding, cough, laryngalgia, lung abscess, acute mastitis, furuncle, burn, snakebite.
Margarita, the property sweet-salty, cold.Enter the heart, Liver Channel.Function cures mainly: tranquilizing mind, yin nourishing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., heat clearing away pendant expectorant, removing nebula improving eyesight, removing toxic substances and promoting granulation.Control palpitation with fear, palpitation with a distress feeling, epilepsy, infantile convulsion is twitched, and dysphoria with smothery sensation is quenched one's thirst, the sore throat aphtha, order is given birth to cataracta, and skin infection does not close up for a long time.
Realgar, the acrid in the mouth hardship, temperature, poisonous.Enter the heart, liver, stomach warp.Function cures mainly: dampness, dispel the wind, and parasite killing, removing toxic substances.Control scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, snakeworm Eriocheir sinensis wound, bromhidrosis, ecthyma, asthma, sore throat, infantile convulsion, hemorrhoid complicated by anal fistula.
Stigma Croci, nature and flavor, sweet, flat.Enter the heart, Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens.Control troubled thoughts pent-up, the chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, frightened fear in a trance, women's amenorrhea, postnatal blood stasis stomachache, tumbling and swelling.
Scolopendra, acrid in the mouth, temperature, poisonous.Enter Liver Channel.Function cures mainly: dispels the wind, and arresting convulsion, counteracting toxic substances, eliminating stagnation.Control apoplexy, infantile convulsion, tetanus, pertussis, scrofula, tuberculosis, hundred buildup pieces, sore swollen toxin, tinea corporis, bald in vain, anal fistula, scald.
Herba Solani Lyrati, cold in nature, sweet in the mouth; Slightly poisonous.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, blood stasis dispelling.For jaundice due to damp-heat, headache due to pathogenic wind-heat, leukorrhagia, rheumatic arthritis.
Radix Trichosanthis, the sweet in the mouth picric acid is cool.Enter lung, stomach warp.Function cures mainly: promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturize, evacuation of pus, detumescence.Control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.
Herba Solani Nigri, bitter in the mouth, cold.Function cures mainly: heat clearing away, removing toxic substances, invigorate blood circulation, detumescence.Control furuncle, carbuncle, erysipelas, osteopatia sprain, chronic tracheitis, acute nephritis.For sore and toxic, skin eczema, dysuria, senile chronic tracheitis, leukorrhagia, prostatitis, dysentery.
Herba Verbenae, bitter in the mouth is cool. enter liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, inducing diuresis to remove edema.Control fever caused by exogenous pathogens, jaundice due to damp-heat, edema, dysentery, malaria, diphtheria, sore throat, gonorrhea, amenorrhea, hundred abdominal masss, carbuncle sore tumefacting virus, ulcerative gingivitis.
Radix Rehmanniae, sweet-bitter flavor, cold.Enter the heart, liver, kidney channel.Function cures mainly: heat clearing away, removing heat from blood, promote the production of body fluid.Control the epidemic febrile disease impairment of YIN, large hot excessive thirst, crimson tongue, coma, macule, spit blood, epistaxis, the asthenia hectic fever due to YIN-deficiency, hemoptysis, quench one's thirst, constipation, metrorrhagia.
The Radix Paeoniae Alba, bitter in the mouth acid, cool.Enter liver, spleen channel.Function cures mainly: nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Ganoderma, warm in nature, lightly seasoned.Function cures mainly: strengthening by means of tonics.For brain-strengthening, antiinflammatory, diuresis, kidney tonifying.
Rhizoma Sparganii, the bitter in the mouth suffering, flat.Enter liver.Spleen channel.Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control hundred abdominal masss and gather, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis stomachache, traumatic injury.Skin ulcer is swollen hard.
Fructus Evodiae, the acrid in the mouth hardship, temperature, poisonous.Enter liver, stomach warp.Function cures mainly: warming middle-JIAO, and pain relieving, regulate the flow of vital energy, dampness, the contrary acid regurgitation of stopping vomiting, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.
Radix Arnebiae (Radix Lithospermi), bitter in the mouth, cold.Enter percardium, Liver Channel.Function cures mainly: removing heat from blood, invigorate blood circulation, and heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, nosebleed, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
Herba Andrographis, bitter in the mouth, cold in nature, nontoxic.Enter the heart, lung two warps.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood detumescence.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Colla cornus cervi, sweet-salty, temperature.Enter liver, kidney channel.Function cures mainly: enriches blood, and the benefit essence.Control deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, uterus cold caused by deficiency, metrorrhagia, leukorrhagia.
Bulbus Tulipae, sweet in the mouth, cold, poisonous.Function cures mainly: eliminating stagnation, blood stasis dispelling.Control laryngopharynx swelling and pain, scrofula, carbuncle, skin ulcer is swollen, and puerperal, the stasis of blood was stagnant.
Daphne giraldii Nitsche, the acrid in the mouth hardship, temperature, slightly poisonous.Function cures mainly: expelling wind and removing dampness, pain relieving dissipating blood stasis.The dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, headache, stomachache, traumatic injury.
Radix Boehmeriae, sweet in the mouth, cold, nontoxic.Cure mainly: the cough asthma due to stagnation of phlegm, urinary obstruction, the urine stranguria with blood, pregnant fetal movement, swelling and pain of anus, proctoptosis is not received, and carbuncle on the back is from the beginning of, erysipelas, and knife injury is lost.
Further preferably, the Chinese medicine composition of the side effect that described chemotherapy causes only consists of said components.
Wherein, the ratio of weight and number of various components can be preferably: Squama Manis 15-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-20 weight portion, Radix Ginseng 5-15 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
Further, the ratio of weight and number of various components also can be preferably: Squama Manis 20-25 weight portion, Radix Astragali 20-30 weight portion, Radix Curcumae 5-8 weight portion, grape leaf 10-20 weight portion, Radix Ginseng 5-10 weight portion, Radix Linderae 10-15 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-12 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-20 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-15 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-15 weight portion, Fructus Evodiae 10-15 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-15 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how the application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
The preparation of embodiment 1 Chinese medicine composition composition granule 1 of the present invention
By Squama Manis 20g, Radix Astragali 20g, Radix Curcumae 5g, grape leaf 10g, Radix Ginseng 5g, Radix Linderae 10g, Rhizoma Polygoni Cuspidati 10g, Calculus Bovis 10g, Thallus Laminariae (Thallus Eckloniae) 10g, ear 10g, Radix et Caulis Opuntiae Dillenii 10g, Margarita 10g, Realgar 5g, Stigma Croci 10g, Scolopendra 10g, Herba Solani Lyrati 10g, Radix Trichosanthis g, Herba Solani Nigri 5g, Radix Rehmanniae 15g, Herba Verbenae 10g, Radix Paeoniae Alba 10g, Ganoderma 10g, Rhizoma Sparganii 10g, Fructus Evodiae 10g, Radix Arnebiae (Radix Lithospermi) g, Herba Andrographis 10g, Colla cornus cervi 10g, Bulbus Tulipae 10g, Daphne giraldii Nitsche 10g, Radix Boehmeriae 10g.Mix and pulverize; Add the water with respect to mixture quality 2000ml, decoct and process 2 hours, decoction liquor is filtered, concentration, to remove the mastic of moisture, the ethanol that is 65%～75% by the determining alcohol that adds 2000ml in the mastic of acquisition, stirred 30 minutes, 0～4 ℃ of lower cold preservation 1.5 hours, filtered, decompression recycling ethanol, add appropriate medicinal dextrin mix homogeneously, granulate, dry, be ground into 100 purpose powder, granulation agent (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 2 Chinese medicine composition composition granule 2 of the present invention
Squama Manis 25g, Radix Astragali 30g, Radix Curcumae 8g, grape leaf 20g, Radix Ginseng 10g, Radix Linderae 15g, Rhizoma Polygoni Cuspidati 15g, Calculus Bovis 15g, Thallus Laminariae (Thallus Eckloniae) 30g, ear 15g, Radix et Caulis Opuntiae Dillenii 15g, Margarita 15g, Realgar 10g, Stigma Croci 15g, Scolopendra 12g, Herba Solani Lyrati 12g, Radix Trichosanthis 10g, Herba Solani Nigri 10g, Radix Rehmanniae 20g, Herba Verbenae 15g, Radix Paeoniae Alba 15g, Ganoderma 15g, Rhizoma Sparganii 15g, Fructus Evodiae 15g, Radix Arnebiae (Radix Lithospermi) 15g, Herba Andrographis 15g, Colla cornus cervi 15g, Bulbus Tulipae 15g, Daphne giraldii Nitsche 15g, Radix Boehmeriae 15g.Mix and pulverize; Add the water with respect to mixture quality 1500ml, decoct and process 2 hours, decoction liquor is filtered, concentration, to remove the mastic of moisture, the ethanol that is 65%～75% by the determining alcohol that adds 2000ml in the mastic of acquisition, stirred 30 minutes, 0～4 ℃ of lower cold preservation 1.5 hours, filtered, decompression recycling ethanol, add appropriate medicinal dextrin mix homogeneously, granulate, dry, be ground into 100 purpose powder, granulation agent (every 1g is equivalent to crude drug in whole 2g).
The preparation of embodiment 3 Chinese medicine composition composition injection of the present invention
Squama Manis 22g, Radix Astragali 25g, Radix Curcumae 5g, grape leaf 15g, Radix Ginseng 5g, Radix Linderae 10g, Rhizoma Polygoni Cuspidati 12g, Calculus Bovis 10g, Thallus Laminariae (Thallus Eckloniae) 10g, ear 10g, Radix et Caulis Opuntiae Dillenii 10g, Margarita 10g, Realgar 6g, Stigma Croci 12g, Scolopendra 10g, Herba Solani Lyrati 11g, Radix Trichosanthis 7g, Herba Solani Nigri 8g, Radix Rehmanniae 15g, Herba Verbenae 10g, Radix Paeoniae Alba 12g, Ganoderma 10g, Rhizoma Sparganii 10g, Fructus Evodiae 12g, Radix Arnebiae (Radix Lithospermi) 10g, Herba Andrographis 10g, Colla cornus cervi 13g, Bulbus Tulipae 10g, Daphne giraldii Nitsche 14g, Radix Boehmeriae 10g.Mix and pulverize; After with 3500 water, medical material being soaked to 2 hours, then with fire, decoct to boiling, then decoct 30 minutes with little fire, filter, filtering residue decocts twice, each 1 hour with little fire.Merging filtrate, adding ethanol to ethanol content in filtrate after filtrate is concentrated is 70%, filters, and filtrate recycling ethanol, be concentrated into every 1ml and be equivalent to crude drug in whole 1g, and cold preservation, filtration, fine straining, embedding, sterilizing, be prepared into injection.
Embodiment 4 toxicity tests
Acute toxicity test
(1) test is prepared
A, to select 60 of Kunming white mice, weight be 18-22g (male and female each 30)
The processing of B, test specimen: get 30g Chinese medicine composition composition granule 1 of the present invention, add distilled water 50ml, forming content through grinding is that the full slurry of 600mg/ml is standby.
(2) oral medication: get 30 of Kunming white mice (each 15 of male and female), weight is 18-22g/, every white mice gives the equal serosity 0.5ml of sample gavage, give altogether twice (be 4 hours interval time), accumulated dose is 1ml, observes 10 days, and white mice is healthy existence all, without any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group, compare zero difference.
(3) injection: get 30 of Kunming white mice (each 15 of male and female), weight is 18-22g/, every white mice gives Chinese medicine composition composition injection 0.25ml of the present invention intramuscular injection, gives altogether twice (be 4 hours interval time), and accumulated dose is 0.5ml.Observe 10 days, white mice is healthy existence all, without any toxicity, through anatomic observation hemogram, liver function, each organs and tissues morphology finding and matched group, compares zero difference.
2, accumulation toxicity test
(1) test is prepared
A, select 30 of ages of rat 6-8 week (each 15 of male and female);
The processing of B, test specimen: get 30g Chinese medicine composition composition granule 1 of the present invention, add distilled water 50ml, through grinding to form screened stock, can add 1% right Sodium Tvlose suspending, the homogenate that to make content be 600mg/ml is standby.
(2) oral medication: get 30 of rat (each 15 of male and female), divide three dosage groups, be divided into three groups by the rat of choosing at random, 10 every group, (each 5 of male and female), give respectively the sample homogenate gavage of every rat 0.4ml every day, 0.25ml, 0.1ml, observe 30 days, rat is healthy existence all, without any toxicity, compare zero difference through anatomic observation hemogram, liver function, each organs and tissues form finding and matched group, nothing savings in the rat body.
The above results explanation: pharmaceutical preparation of the present invention is safe to the medicine for the human clinical, and it is nontoxic, have no side effect, without savings.
The concrete clinical experiment of embodiment 5
This organizes 72 routine patients, is case history in hospital, through the cytology, is diagnosed as malignant tumor, and life cycle>June is estimated in whole body muscle power scoring (KPS scoring)>70 minutes, and routine blood test, Liver and kidney merit, cardiac function are all normal, without obvious chemotherapy, avoids.Be divided at random two groups: observation group's 36 examples, just control 24 examples, control again 12 examples, wherein the male is 23 examples, the women is 13 examples; Age 34-69 year, 49.8 years old mean age.Matched group 36 examples, just control 20 examples, controls again 16 examples, and wherein the male is 20 examples, and the women is 16 examples; Age 35-71 year, 46.9 years old mean age.The sex of two groups, age, histological type, the past diagnosis and treatment situation and KPS scoring are through statistical procedures (all applying statistic software SPSS 16.0), and there was no significant difference, have comparability.
Two groups of concrete conditions are as following table:
Therapeutic Method: pulmonary carcinoma (be all the non-small cell patient, comprise two types: adenocarcinoma, scale cancer) patient, adenocarcinoma patient adopts pemetrexed disodium (Pem) 500mg/m
2Intravenous drip the 1st day, cisplatin (DDP) 25mg/m
2Intravenous drip 1-3 days.Every 3 weeks repeat once.The scale cancer patient applies gemcitabine (GEM) 1000mg/m
2Intravenous drip the 1st, 8 days, cisplatin (DDP) 25mg/m
2Intravenous drip 1-3 days.Every 3 weeks repeat.Breast carcinoma (being postoperative adjuvant therapy) adopts the CAF scheme: cyclophosphamide (CTX) 500mg/m
2Intravenous drip the 1st day, amycin (ADM) 50mg/m
2Intravenous drip the 1st day, fluorouracil (5-FU) 500mg/m
2Intravenous drip the 1st, 8 days, every 3 weeks repeat.Colon cancer and gastric cancer adopt the OLF scheme: oxaliplatin (L-OHP) 85mg/m
2Intravenous drip the 1st day, calcium folinate (CF) 200mg/m
2Intravenous drip 1-5 days, fluorouracil (5-FU) 350mg/m
2Intravenous drip 1-5 days, every 3 weeks repeat.The esophageal carcinoma adopts the PF scheme: cisplatin (DDP) 20mg/m
2Intravenous drip 1-5 days, calcium folinate (CF) 200mg/m
2Intravenous drip 1-5 days, fluorouracil (5-FU) 350mg/m
2Intravenous drip 1-5 days, every 3 weeks repeat.Two groups of patients all use the such scheme combined chemotherapy, and conventional application 5-hydroxytryptamine receptor antagonist emesis, observation group is oral Chinese medicine treatment (Chinese medicine composition composition granule 2 after chemotherapy, 0.1g/kg), carry out with chemotherapy simultaneously, be used in conjunction 14 days, stop 7 days, carry out oral medication the 2nd the 2nd time when the cycle, chemotherapy started, more than applying for 2 cycles.Above patient is all in chemotherapy 2-3 cycle post-evaluation curative effect.
Observation index: short term effect is with reference to RECIST1.0 solid tumor the standard of curative effect evaluation; Toxic and side effects, according to WHO standard, is mainly observed gastrointestinal symptom, routine blood test variation, hepatic and renal function variation.Result is as following table:
Recent effective percentage:
Therapeutic outcome: short term effect: observation group's focus is alleviated and partial rcsponse 24 examples fully totally, and effective percentage is 66.7%, and matched group is 22 examples, and effective percentage is 61.1%, both no difference of science of statistics.(P＞0.05)
The toxic and side effects incidence rate of chemotherapy: the toxic and side effects incidence rate of two groups sees the following form:
Observation group feels sick, the incidence rate of vomiting, leukopenia, liver function damage is starkly lower than matched group (P<0.05), and the incidence rate of stomatitis and diarrhoea is also lower than matched group, but no difference of science of statistics (P>0.05).Both kidney merit damages are all rare, no significant difference (P>0.05).
Therefore medicine, in the malignant tumor chemotherapies such as digestive system tumor, respiratory system tumor, breast carcinoma, can play the effect of auxiliary treatment, reduces the chemotherapeutic period untoward reaction, the effect of tonifying speen and tonifying kidney.
According to other improvement and the modification of further embodiment of the present invention, according to above-mentioned instruction, be feasible.The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.Thus, will be understood that, within the scope of the appended claims, the present invention can the mode except this paper specifically describes implement.
Claims (6)
1. a Chinese medicine composition that is used for the treatment of the side effect that chemotherapy causes; it is characterized in that; comprise: Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae.
2. Chinese medicine composition as claimed in claim 1, wherein, Chinese medicine composition comprises Squama Manis 10-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-25 weight portion, Radix Ginseng 5-20 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-20 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-20 weight portion, Scolopendra 10-15 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 10-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-25 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-20 weight portion, Herba Andrographis 10-20 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
3. Chinese medicine composition as claimed in claim 1, wherein, Chinese medicine composition comprises Squama Manis 15-40 weight portion, Radix Astragali 10-40 weight portion, Radix Curcumae 5-10 weight portion, grape leaf 5-20 weight portion, Radix Ginseng 5-15 weight portion, Radix Linderae 10-20 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-25 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-25 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-25 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-25 weight portion, Fructus Evodiae 10-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-25 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
4. Chinese medicine composition as claimed in claim 1, wherein, Chinese medicine composition comprises Squama Manis 20-25 weight portion, Radix Astragali 20-30 weight portion, Radix Curcumae 5-8 weight portion, grape leaf 10-20 weight portion, Radix Ginseng 5-10 weight portion, Radix Linderae 10-15 weight portion, Rhizoma Polygoni Cuspidati 10-15 weight portion, Calculus Bovis 10-15 weight portion, Thallus Laminariae (Thallus Eckloniae) 10-30 weight portion, ground ear 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Margarita 10-15 weight portion, Realgar 5-10 weight portion, Stigma Croci 10-15 weight portion, Scolopendra 10-12 weight portion, Herba Solani Lyrati 10-12 weight portion, Radix Trichosanthis 5-10 weight portion, Herba Solani Nigri 5-10 weight portion, Radix Rehmanniae 15-20 weight portion, Herba Verbenae 10-15 weight portion, Radix Paeoniae Alba 10-15 weight portion, Ganoderma 10-15 weight portion, Rhizoma Sparganii 10-15 weight portion, Fructus Evodiae 10-15 weight portion, Radix Arnebiae (Radix Lithospermi) 10-15 weight portion, Herba Andrographis 10-15 weight portion, Colla cornus cervi 10-15 weight portion, Bulbus Tulipae 10-15 weight portion, Daphne giraldii Nitsche 10-15 weight portion, Radix Boehmeriae 10-15 weight portion.
5. Chinese medicine composition as claimed in claim 1; wherein; Chinese medicine composition comprises that compositions is only by Squama Manis, the Radix Astragali, Radix Curcumae, grape leaf, Radix Ginseng, the Radix Linderae, Rhizoma Polygoni Cuspidati, Calculus Bovis, Thallus Laminariae (Thallus Eckloniae), ear, Radix et Caulis Opuntiae Dillenii, Margarita, Realgar, Stigma Croci, Scolopendra, Herba Solani Lyrati, Radix Trichosanthis, Herba Solani Nigri, Radix Rehmanniae, Herba Verbenae, the Radix Paeoniae Alba, Ganoderma, Rhizoma Sparganii, Fructus Evodiae, Radix Arnebiae (Radix Lithospermi), Herba Andrographis, Colla cornus cervi, Bulbus Tulipae, Daphne giraldii Nitsche, Radix Boehmeriae form.
6. the application in the described side effect caused in the treatment chemotherapy of any one in claim 1-5.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104491187A (en) * | 2015-01-16 | 2015-04-08 | 孙士强 | External use ointment capable of preventing radiation and preparation method thereof |
| CN105055868A (en) * | 2015-07-21 | 2015-11-18 | 周善良 | Traditional Chinese medicine preparation for preventing and controlling toxic and side reaction of colon cancer chemotherapy |
| CN107569607A (en) * | 2017-08-08 | 2018-01-12 | 张振亚 | A kind of health products for nursing one's health tumor chemoradiotherapy side effect |
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| CN101112495A (en) * | 2007-07-30 | 2008-01-30 | 牛昱翔 | Chinese medicine for curing tumor |
| CN102327390A (en) * | 2011-10-18 | 2012-01-25 | 周国生 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101112495A (en) * | 2007-07-30 | 2008-01-30 | 牛昱翔 | Chinese medicine for curing tumor |
| CN102327390A (en) * | 2011-10-18 | 2012-01-25 | 周国生 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491187A (en) * | 2015-01-16 | 2015-04-08 | 孙士强 | External use ointment capable of preventing radiation and preparation method thereof |
| CN104491187B (en) * | 2015-01-16 | 2018-08-14 | 孙士强 | A kind of externally-applied ointment and preparation method thereof with radiation protection |
| CN105055868A (en) * | 2015-07-21 | 2015-11-18 | 周善良 | Traditional Chinese medicine preparation for preventing and controlling toxic and side reaction of colon cancer chemotherapy |
| CN107569607A (en) * | 2017-08-08 | 2018-01-12 | 张振亚 | A kind of health products for nursing one's health tumor chemoradiotherapy side effect |
| CN107569607B (en) * | 2017-08-08 | 2021-01-08 | 张振亚 | Composition for conditioning side effects of tumor radiotherapy and chemotherapy and preparation method thereof |
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