CN104491752A - Liver-soothing and heat-clearing agent for treating chronic persistent hepatitis and preparation method thereof - Google Patents
Liver-soothing and heat-clearing agent for treating chronic persistent hepatitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a liver-soothing and heat-clearing agent for treating chronic persistent hepatitis. The liver-soothing and heat-clearing agent is mainly prepared from the following crude drugs in parts by weight: 9-15 parts of spreading hedyotis herb, 10-15 parts of largehead atractylodes rhizome, 6-9 parts of old radish root, 12-25 parts of turmeric root-tuber, 9-16 parts of danshen root, 8-12 parts of grifola, 10-20 parts of bitter orange, 10-20 parts of white peony root, 4-9 parts of mirabilite (added in a later period), 9-16 parts of herb of epimedium, 8-12 parts of phyllanthus urinaria, 9-18 parts of barbed skullcap herb, 9-16 parts of pyrola herb, 8-16 parts of maifanitum, 7-10 parts of Japanese ardisia herb and 15-30 parts of Chinese magnoliavine fruit. The preparation method of each dosage form of the liver-soothing and heat-clearing agent disclosed by the invention is simple, the selected materials are low in price and easy to obtain, and the composition completely accords with a traditional Chinese medicine principle, so that the liver-soothing and heat-clearing agent has effects of reducing fever and causing diuresis, soothing the liver and strengthening the spleen, tonifying the stomach and promoting fluid as well as removing blood stasis and relieving pain, and the obtained product is significant in curative effect, short in period of treatment, quick in response, and capable of treating both symptoms and root causes.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the agent of a kind of chronic persistent hepatitis Shugan Qingre and preparation method.
Background technology
Hepatitis is the general designation of inflammation, typically refer to by multiple paathogenic factor--as virus, antibacterial, parasite, chemical toxicant, medicine, ethanol, role of autoimmune factors etc. make liver cell be damaged, the function of liver suffers damage, cause a series of malaise symptoms of health, and the exception of liver function index.The protracteds course of disease such as hepatitis B, the course of disease exceedes will change chronic persistent hepatitis into half a year, and the symptom of chronic persistent hepatitis, sign and abnormal liver function are comparatively light, without self immune system and the existing hepatitis of other system tables.Patient often occur slightly weak, pain in the hepatic region, appetite are poor, abdominal distention etc., also can non-evident sympton.Often slightly large with liver, spleen sometimes also can enlargement, but without Progressive symmetric erythrokeratodermia enlargement.General without jaundice, transaminase continue or interval raise, plasma albumin and globulin numerical value normal, zinc sulfate turbidity is normal.In Chinese medicine, acute hepatitis protracted course of disease, damp and hotly stays change, and liver disease affecting spleen, stagnation of QI blood addiction becomes chronic hepatitis, can dialectical part be caused by hepatic stagnation qi stagnation, liver-depression and spleen-insufficiency type, qi stagnation and blood stasis type, liver-kidney yin deficiency, should with yin nourishing easing the affected liver during treatment, clearing away heat-damp and promoting diuresis, dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating the spleen and regulating the stomach is main.Publication number CN 103211870 A(application number 201310175314.0) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of chronic hepatitis and preparation method thereof, said composition primarily of Fructus Schisandrae Chinensis extrat, baicalin, Radix Glycyrrhizae extract, Fructus Mori Radix Salviae Miltiorrhizae extractum totally four kinds of Chinese medicine extract be prepared from through processing.Publication number CN 101745076 A(application number 200810238368.6) Chinese patent literature disclose a kind of Chinese medicine for the treatment of chronic persistent hepatitis, mainly with Herba Artemisiae Scopariae, Herba Cirsii, Herba Salviae Chinensis, Radix Bupleuri (processed with vinegar), wine Radix Gentianae, Radix Curcumae, Radix Paeoniae Rubra, Cortex Moutan, Alumen, Herba Lycopi for raw material.Publication number CN 103099841 A(application number 201310053451.7) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of hepatitis, said composition is made up of Thallus Laminariae (Thallus Eckloniae) extract, Extraction of Eucheuma gelatinae, Semen Trigonellae and Herba Erodii.
Current, medicine about treating hepatitis has many, but effect is all unsatisfactory, Western medicine side effect is large, costly, easy recurrence, the achievement in research that Chinese medicine is existing certain on treatment hepatitis, but the effect of most traditional Chinese medical science formula is single, and specific aim is poor, take effect slow, the demand of patient can not be met well.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of safe and reliable, taking convenience, be easy to carry, chronic persistent hepatitis Shugan Qingre agent and preparation method thereof of easy clothes for a long time.
Technical scheme of the present invention is:
The agent of chronic persistent hepatitis Shugan Qingre, is prepared from primarily of following bulk drugs, is weight portion: Herba Hedyotidis Diffusae 9-15, Rhizoma Atractylodis Macrocephalae 10-15, Radix Raphani 6-9, Radix Curcumae 12-25, Radix Salviae Miltiorrhizae 9-16, Polyporus 8-12, Fructus Aurantii 10-20, Radix Paeoniae Alba 10-20, Natrii Sulfas (entering afterwards) 4-9, Herba Epimedii 9-16, Cacumen Securinegae Suffruticosae 8-12, Herba Scutellariae Barbatae 9-18, Herba Pyrolae 9-16, Maifanitum 8-16, PINGDIMU 7-10, Fructus Schisandrae Chinensis 15-30.
In preferred scheme, Herba Hedyotidis Diffusae 10-14, Rhizoma Atractylodis Macrocephalae 11-14, Radix Raphani 7-8, Radix Curcumae 15-22, Radix Salviae Miltiorrhizae 10-15, Polyporus 9-11, Fructus Aurantii 12-18, Radix Paeoniae Alba 12-18, Natrii Sulfas (entering afterwards) 5-8, Herba Epimedii 10-15, Cacumen Securinegae Suffruticosae 9-11, Herba Scutellariae Barbatae 10-17, Herba Pyrolae 10-15, Maifanitum 10-14, PINGDIMU 8-9, Fructus Schisandrae Chinensis 20-25.
Be more preferably, Herba Hedyotidis Diffusae 12, the Rhizoma Atractylodis Macrocephalae 12.5, Radix Raphani 7.5, Radix Curcumae 18.5, Radix Salviae Miltiorrhizae 12.5, Polyporus 10, Fructus Aurantii 15, the Radix Paeoniae Alba 15, Natrii Sulfas (entering afterwards) 6.5, Herba Epimedii 12.5, Cacumen Securinegae Suffruticosae 10, Herba Scutellariae Barbatae 13.5, Herba Pyrolae 12.5, Maifanitum 12, PINGDIMU 8.5, Fructus Schisandrae Chinensis 22.5.
The preparation method of described chronic persistent hepatitis Shugan Qingre agent decoction is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 140-200 mesh sieve and (preferably, pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves);
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, soak 40 minutes, then big fire is boiled, and a turn little fire decocts 30-60 minute, and (preferred, 40-50 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 45 minutes), filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, heating is concentrated into 1/2 of original volume, obtains decoction.
The preparation method of described chronic persistent hepatitis Shugan Qingre agent decoction, step (4) amount of water was not for have medical material 3cm.
The preparation method of described unguentum is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 140-200 mesh sieve and (preferably, pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves);
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, soak 40 minutes, then big fire is boiled, and a turn little fire decocts 30-60 minute, and (preferred, 40-50 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 45 minutes), filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, heating is concentrated into thick paste, obtains unguentum.
The preparation method of described chronic persistent hepatitis Shugan Qingre agent unguentum, the relative density of step (5) thick paste is 1.20-1.32(50 DEG C) (preferred, relative density is 1.22-1.30(50 DEG C); Be more preferably, relative density is 1.26(50 DEG C)).
The preparation method of described pill is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) be placed in pot by Maifanitum, add water, boil 20 minutes, it is wooden pacifically then to put into clean Herba Epimedii, Cacumen Securinegae Suffruticosae, Herba Scutellariae Barbatae, Herba Pyrolae, and little fire decocts 20-40 minute, and (preferred, 25-35 minute decocted by little fire; Be more preferably, little fire decocts 30 minutes), filter, collect filtrate, concentrated, dry;
(4) other residue medical materials are pulverized 120-160 mesh sieve (preferred, pulverized 140 mesh sieves) together with step (1) (2) made medical material and the made dry thing of step (3), then added water, generally make ball.
The preparation method of described chronic persistent hepatitis Shugan Qingre agent pill, step (3) amount of water is total quality of medicinal material 6 times.
The preparation method of described tablet is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) be placed in pot by Maifanitum, add water, boil 20 minutes, it is wooden pacifically then to put into clean Herba Epimedii, Cacumen Securinegae Suffruticosae, Herba Scutellariae Barbatae, Herba Pyrolae, and little fire decocts 20-40 minute, and (preferred, 25-35 minute decocted by little fire; Be more preferably, little fire decocts 30 minutes), filter, collect filtrate, concentrated, dry;
(4) by other residue medical material and step (1) (2) made medical material, and the made dry thing of step (3) pulverized 120-160 mesh sieve (preferred, to pulverize 140 mesh sieves) together, and add starch slurry soft material, granulate, dry, granulate, tabletting, obtains tablet.
The preparation method of described chronic persistent hepatitis Shugan Qingre agent tablet, the temperature that step (4) is dried is 60-80 DEG C (preferred, the temperature of oven dry is 70 DEG C).
Chronic persistent hepatitis Shugan Qingre agent scientific formula provided by the invention, stable components, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, each dosage form preparation method of the present invention is simple, and selected materials is cheap and easy to get;
2, this prescription meets Chinese medicine principle completely, has clearing away heat and promoting diuresis, soothing liver and strengthening spleen, reinforcing stomach reg fluid, stasis-dispelling and pain-killing effect;
3, invention formulation is evident in efficacy, short treating period, instant effect, can treating both the principal and secondary aspects of a disease.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Hedyotidis Diffusae: base is former: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae.Nature and flavor: sweet, light, cool.Gui Jing: enter stomach, large intestine, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.
The Rhizoma Atractylodis Macrocephalae: base is former: be the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Nature and flavor: bitter, sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Radix Raphani: base is former: be the old root of crucifer Radix Raphani.Nature and flavor: Gan Xin are flat.Gui Jing: lung; Kidney channel.Function cures mainly: dispersing lung-QI and dissipating phlegm, helps digestion, diuretic.Control cough ant phlegm, stagnation of QI due to dyspepsia, the vexed distending pain of gastral cavity abdomen painful abdominal mass, edema dyspnea with fullness of the chest, fasting dysentery disease.
Radix Curcumae: base is former: be the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Nature and flavor: pungent, bitter, cold.Gui Jing: return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Radix Salviae Miltiorrhizae: base is former: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Nature and flavor: bitter, are slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Polyporus: base is former: be the dry sclerotia of On Polyporaceae Polyporus.Nature and flavor: sweet, light are flat.Gui Jing: return kidney, urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen.For dysuria, edema, has loose bowels, stranguria with turbid discharge, leukorrhagia.
Fructus Aurantii: base is former: be the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
The Radix Paeoniae Alba: base is former: be the dry root of ranunculaceae plant Radix Paeoniae.Nature and flavor: bitter, sour, are slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Natrii Sulfas: base is former: be Sulfates mineral Natrii Sulfas race Natrii Sulfas, through the crystalline solid of processing and refining.Nature and flavor: salty, bitter, cold.Gui Jing: return stomach, large intestine channel.Function cures mainly: purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.For excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swells and ache; External treatment acute mastitis, swelling and pain of hemorrhoid.
Cacumen Securinegae Suffruticosae: base is former: be Euphorbiaceae phyllanthus emblica platymiscium Cacumen Securinegae Suffruticosae herb.Nature and flavor: micro-hardship, sweet, cool.Function cures mainly: clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, young waiter in a wineshop or an inn's infantile malnutrition, eye keratitis, icterohepatitis; External is controlled Trimeresurus stejnegeri and is bitten.
Herba Epimedii (Herba Epimedii): base is former: be the stem and leaf of Berberidaceae plant Herba Epimedii, Epimedium brevicornum or Epimedium sagittatum.Nature and flavor: acrid, sweet, warm.Gui Jing: return liver, kidney channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Herba Scutellariae Barbatae: base is former: be the dry herb of labiate Herba Scutellariae Barbatae.Nature and flavor: pungent, bitter, cold.Gui Jing: return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Herba Pyrolae: base is former: be the dry herb of Pyrolaceae plant Herba pyrolae japonicae or ovum leaf Herba pyrolae japonicae.Nature and flavor: sweet, bitter, temperature.Gui Jing: return liver, kidney channel.Function cures mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Maifanitum: base is former: be Acid-intermediate igneous rock rocks beschtauite.Nature and flavor: sweet; Temperature; Nontoxic.Gui Jing: liver; Stomach; Kidney channel.Function cures mainly: detoxicating and resolving stagnation of pathogens; Removing the necrotic tissue and promoting granulation; Except cold damp eliminating; The liver benefiting stomach invigorating; Blood circulation promoting and blood stasis dispelling; Diuresis fossil; Life lengthening.Main carbuncle carbuncle on the back; Acne; Eczema; Foot gas; Miliaria; Finger is chapped; Chloasma; Toothache; Oral ulcer; Rheumatic arthralgia; Lumbago and backache; Chronic hepatitis; Gastritis; Dysentery; Diabetes; Neurasthenia; Wound is red and swollen; Hypertension; Senile sclerosis of blood vessels; Tumor; Lithangiuria.
PINGDIMU: base is former: be the Herb of Myrsinacea plant PINGDIMU.Nature and flavor: pungent; Micro-hardship; Property is put down.Gui Jing: lung; Liver Channel.Function cures mainly: preventing phlegm from forming and stopping coughing; Dampness removing; Invigorate blood circulation.Main new chronic cough is coughed; Sputum mixed with blood; Jaundice; Edema; Stranguria; Leucorrhea; Amenorrhea dysmenorrhea; Rheumatic arthralgia; Traumatic injury; Painful and swollen testis.
Fructus Schisandrae Chinensis: base is former: be the dry mature fruit of magnoliaceae schisandra or schisandra chinensis.Nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
embodiment 1the agent of chronic persistent hepatitis Shugan Qingre, is prepared from primarily of following bulk drugs: Herba Hedyotidis Diffusae 9g, Rhizoma Atractylodis Macrocephalae 10g, Radix Raphani 6g, Radix Curcumae 12g, Radix Salviae Miltiorrhizae 9g, Polyporus 8g, Fructus Aurantii 10g, Radix Paeoniae Alba 10g, Natrii Sulfas (entering afterwards) 4g, Herba Epimedii 9g, Cacumen Securinegae Suffruticosae 8g, Herba Scutellariae Barbatae 9g, Herba Pyrolae 9g, Maifanitum 8g, PINGDIMU 7g, Fructus Schisandrae Chinensis 15g.
The preparation method of above-mentioned chronic persistent hepatitis Shugan Qingre agent decoction is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 25 minutes, take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 170 mesh sieves;
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, add the water soaking 40 minutes no medical material 3cm, then big fire is boiled, and turns a little fire and decocts 45 minutes, filter, collection filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, heating is concentrated into 1/2 of original volume, obtains decoction.
embodiment 2the agent of chronic persistent hepatitis Shugan Qingre, is prepared from primarily of following bulk drugs: Herba Hedyotidis Diffusae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Raphani 9g, Radix Curcumae 25g, Radix Salviae Miltiorrhizae 16g, Polyporus 12g, Fructus Aurantii 20g, Radix Paeoniae Alba 20g, Natrii Sulfas (entering afterwards) 9g, Herba Epimedii 16g, Cacumen Securinegae Suffruticosae 12g, Herba Scutellariae Barbatae 18g, Herba Pyrolae 16g, Maifanitum 16g, PINGDIMU 10g, Fructus Schisandrae Chinensis 30g.
The preparation method of chronic persistent hepatitis Shugan Qingre agent unguentum is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 25 minutes, take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 170 mesh sieves;
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, soak 40 minutes, then big fire is boiled, and turns little fire and decocts 45 minutes, filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, to be concentrated into relative density be 1.26(50 DEG C in heating) thick paste, obtain unguentum.
Model case: xxx, man, 34 years old.Main suit: suffered from hepatitis B 3 years, take the medicine such as liver-protecting tablet, glucuronolatone during one's sickness, liver function has no normal all the time, can not strenuous exercise, limbs fatigue after motion, check result is hepatitis B surface antigen is positive (HbsAg+), hepatitis B E antigen is positive (HbeAg+), core antibody is positive (anti-HBC+), with hypochondriac pain, dizzy time nervous, be diagnosed as chronic persistent hepatitis.
Take the present embodiment gained chronic persistent hepatitis Shugan Qingre agent unguentum, each 6-8g, every day 2 times, warm boiled water, 10 days courses for the treatment of.After taking one month, hypochondriac pain, dizziness are clearly better, and take after two months, and liver function test is normal, and HbeAg turns negative, and hepatitis B e antibody is positive (Hbe+), and various malaise symptoms all disappears.
embodiment 3the agent of chronic persistent hepatitis Shugan Qingre, is prepared from primarily of following bulk drugs: Herba Hedyotidis Diffusae 10g, Rhizoma Atractylodis Macrocephalae 11g, Radix Raphani 7g, Radix Curcumae 15g, Radix Salviae Miltiorrhizae 10g, Polyporus 9g, Fructus Aurantii 12g, Radix Paeoniae Alba 12g, Natrii Sulfas (entering afterwards) 5g, Herba Epimedii 10g, Cacumen Securinegae Suffruticosae 9g, Herba Scutellariae Barbatae 10g, Herba Pyrolae 10g, Maifanitum 10g, PINGDIMU 8g, Fructus Schisandrae Chinensis 20g.
The preparation method of chronic persistent hepatitis Shugan Qingre agent pill is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 25 minutes, take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) be placed in pot by Maifanitum, add up the water of quality of medicinal material 6 times, boil 20 minutes, it is wooden pacifically then to put into clean Herba Epimedii, Cacumen Securinegae Suffruticosae, Herba Scutellariae Barbatae, Herba Pyrolae, and little fire decocts 30 minutes, filters, and collects filtrate, concentrated, dry;
(4) other residue medical materials were pulverized 140 mesh sieves together with step (1) (2) made medical material and the made dry thing of step (3), and then added water, generally make ball.
Model case: xxx, man, 45 years old.Before 2 years, unit health check-up finds to suffer from hepatitis B, hepatomegaly, easy asthenia, drowsiness, and poor appetite, takes interferons medicine, and liver power recovery is normal for the moment, does not have half a year, and recurs again, and patient is very worried, once attempts multiple medicine, but finally all has no result.
Learn the present invention after being introduced, have the attitude of having a try in arms, taken the present embodiment gained chronic persistent hepatitis Shugan Qingre agent pill, adopt twice daily, each 4-7 grain, with warm water delivery service, 10 days courses for the treatment of.After taking one month, patient's self-induction symptom is alleviated to some extent, and extremity are strong comparatively before, and spirit is good, and rear continuation has taken two months, and patient's liver power recovery is normal, and hepatitis B E antigen turns negative, and hepatitis B e antibody is positive, and hepatomegaly reduces.
embodiment 4the agent of chronic persistent hepatitis Shugan Qingre, is prepared from primarily of following bulk drugs: Herba Hedyotidis Diffusae 14g, Rhizoma Atractylodis Macrocephalae 14g, Radix Raphani 8g, Radix Curcumae 22g, Radix Salviae Miltiorrhizae 15g, Polyporus 11g, Fructus Aurantii 18g, Radix Paeoniae Alba 18g, Natrii Sulfas (entering afterwards) 8g, Herba Epimedii 15g, Cacumen Securinegae Suffruticosae 11g, Herba Scutellariae Barbatae 17g, Herba Pyrolae 15g, Maifanitum 14g, PINGDIMU 9g, Fructus Schisandrae Chinensis 25g.
The preparation method of chronic persistent hepatitis Shugan Qingre agent tablet is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 25 minutes, take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) be placed in pot by Maifanitum, add water, boil 20 minutes, it is wooden pacifically then to put into clean Herba Epimedii, Cacumen Securinegae Suffruticosae, Herba Scutellariae Barbatae, Herba Pyrolae, and little fire decocts 30 minutes, filters, and collects filtrate, concentrated, dry;
(4) by other residue medical material and step (1) (2) made medical material, and the made dry thing of step (3) pulverized 140 mesh sieves together, added starch slurry soft material, granulated, and dry at 70 DEG C, granulate, tabletting, obtains tablet.
Model case: xxx, female, 41 years old.Before 4 years, patient's self-induction hypochondriac pain is weak, then to examination in hospital, is diagnosed as hepatitis B great three positive, hospitalization two months, therapeutic effect is undesirable, and only hepatitis B virus amount declines to some extent, and how long does not maintain, just have a rebound, patient, because paying hospitalize expense, leaves hospital and goes home to treat.
After ask about and learn the present invention, take the present embodiment gained chronic persistent hepatitis Shugan Qingre agent tablet, adopt twice daily, each 4-6 sheet, with warm water delivery service, 10 days courses for the treatment of.After taking one month, sense of discomfort obviously alleviates, and rear continuation takes one and a half months, and check finds, liver power recovery is normal, and alpha-fetoprotein recovers normal range, and liver is without enlargement, and hepatitis B E antigen turns negative, and hepatitis B e antibody is positive.
embodiment 5the agent of chronic persistent hepatitis Shugan Qingre, is prepared from primarily of following bulk drugs: Herba Hedyotidis Diffusae 12g, Rhizoma Atractylodis Macrocephalae 12.5g, Radix Raphani 7.5g, Radix Curcumae 18.5g, Radix Salviae Miltiorrhizae 12.5g, Polyporus 10g, Fructus Aurantii 15g, Radix Paeoniae Alba 15g, Natrii Sulfas (entering afterwards) 6.5g, Herba Epimedii 12.5g, Cacumen Securinegae Suffruticosae 10g, Herba Scutellariae Barbatae 13.5g, Herba Pyrolae 12.5g, Maifanitum 12g, PINGDIMU 8.5g, Fructus Schisandrae Chinensis 22.5g.
The preparation method of chronic persistent hepatitis Shugan Qingre agent decoction is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 25 minutes, take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 170 mesh sieves;
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, add the water soaking 40 minutes no medical material 3cm, then big fire is boiled, and turns a little fire and decocts 45 minutes, filter, collection filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, heating is concentrated into 1/2 of original volume, obtains decoction.
test example 1the clinical practice of gained chronic persistent hepatitis Shugan Qingre of the present invention agent (embodiment 5):
The patient that 412 examples are diagnosed as chronic persistent hepatitis is screened, wherein women 187 example, male 225 example, oldest 62 years old, minimal ages 18 years old, 32.2 years old mean age, average course of disease 1-5 at hospital clinic.
Patient is divided into two groups at random, experimental group 282 example and matched group 130 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, take every day twice (warm), each 50m1-100m1(adjusts to some extent depending on concrete condition), 10 days courses for the treatment of, matched group takes other medicine (conventional medication such as Bicyclol, Inosine tablets, chronic hepatitis yin-nourishing capsule, strong liver sheet).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and sign change, after three months, adds up two groups for the treatment of situations.
Curative effect situation criterion: effective: clinical symptoms disappears substantially, hepatosplenomegaly reduces or constant, and without tenderness, hepatic region is without percussion pain, and liver function recovery is normal; Effective: clinical symptoms is obviously improved, hepatosplenomegaly is stablized constant, and without obvious tenderness, hepatic region is without obvious percussion pain, and only have slight uncomfortable liver area or hypochondriac pain, liver function makes moderate progress; Invalid: clinical symptoms, liver function is all not improved, and even increases the weight of.
Relatively two groups of clinical efficacies, in experimental group, effective number of cases has 228 examples (80.9%), and effective number of cases has 46 examples (16.3%), and invalid number of cases has 8 examples (2.8%), and the total effective rate of experimental group is 97.2%; In matched group, effective number of cases has 67 examples (51.5%), effective number of cases has 37 examples (28.5%), invalid number of cases has 26 examples (20.0%), significant difference is there is between two groups of obvious effective rates, better curative effect can be had by the made decoction of the present invention taken of illustrative experiment group compared with matched group medical instrument used, observe two groups of patients symptomatic and sign discovery, it is also many compared with matched group that the symptom of experimental group patient improves ratio, and the made decoction of visible the present invention also effectively can improve the diseases such as patient's jaundice, hypochondriac pain, hepatomegaly, weak and abdominal distention.
The present invention selects Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to remove obstruction in the collateral; Herba Epimedii kidney-replenishing, wind-damp dispelling; Radix Raphani dispersing lung-QI and dissipating phlegm, help digestion diuretic; Polyporus promoting diuresis to eliminate damp pathogen; Fructus Aurantii regulating the flow of QI to ease the stomach; The pain relieving of Radix Paeoniae Alba suppressing the hyperactive liver, nourishing blood for regulating menstruation; Natrii Sulfas purging heat to relax the bowels, moistening for dryness and softening hard mass; Cacumen Securinegae Suffruticosae clearing away heat and promoting diuresis; PINGDIMU preventing phlegm from forming and stopping coughing; Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI; The stomach invigorating of Maifanitum the liver benefiting; Radix Curcumae promoting the function of the gallbladder to alleviate jaundice; Astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of Fructus Schisandrae Chinensis convergence, all medicines share, and play the effects such as clearing away heat and promoting diuresis, soothing liver and strengthening spleen, reinforcing stomach reg fluid, stasis-dispelling and pain-killing altogether, thus, have significant curative effect to chronic persistent hepatitis, and safe and reliable.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. the agent of chronic persistent hepatitis Shugan Qingre, is characterized in that, is prepared from primarily of following bulk drugs, is weight portion: Herba Hedyotidis Diffusae 9-15, Rhizoma Atractylodis Macrocephalae 10-15, Radix Raphani 6-9, Radix Curcumae 12-25, Radix Salviae Miltiorrhizae 9-16, Polyporus 8-12, Fructus Aurantii 10-20, Radix Paeoniae Alba 10-20, Natrii Sulfas (entering afterwards) 4-9, Herba Epimedii 9-16, Cacumen Securinegae Suffruticosae 8-12, Herba Scutellariae Barbatae 9-18, Herba Pyrolae 9-16, Maifanitum 8-16, PINGDIMU 7-10, Fructus Schisandrae Chinensis 15-30.
2. chronic persistent hepatitis Shugan Qingre agent as claimed in claim 1, it is characterized in that, Herba Hedyotidis Diffusae 10-14, Rhizoma Atractylodis Macrocephalae 11-14, Radix Raphani 7-8, Radix Curcumae 15-22, Radix Salviae Miltiorrhizae 10-15, Polyporus 9-11, Fructus Aurantii 12-18, Radix Paeoniae Alba 12-18, Natrii Sulfas (entering afterwards) 5-8, Herba Epimedii 10-15, Cacumen Securinegae Suffruticosae 9-11, Herba Scutellariae Barbatae 10-17, Herba Pyrolae 10-15, Maifanitum 10-14, PINGDIMU 8-9, Fructus Schisandrae Chinensis 20-25 is (preferred, Herba Hedyotidis Diffusae 12, the Rhizoma Atractylodis Macrocephalae 12.5, Radix Raphani 7.5, Radix Curcumae 18.5, Radix Salviae Miltiorrhizae 12.5, Polyporus 10, Fructus Aurantii 15, the Radix Paeoniae Alba 15, Natrii Sulfas (entering afterwards) 6.5, Herba Epimedii 12.5, Cacumen Securinegae Suffruticosae 10, Herba Scutellariae Barbatae 13.5, Herba Pyrolae 12.5, Maifanitum 12, PINGDIMU 8.5, Fructus Schisandrae Chinensis 22.5).
3. the chronic persistent hepatitis Shugan Qingre agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 140-200 mesh sieve and (preferably, pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves);
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, soak 40 minutes, then big fire is boiled, and a turn little fire decocts 30-60 minute, and (preferred, 40-50 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 45 minutes), filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, heating is concentrated into 1/2 of original volume, obtains decoction.
4. the preparation method of chronic persistent hepatitis Shugan Qingre agent decoction as claimed in claim 3, it is characterized in that, step (4) amount of water was not for have medical material 3cm.
5. the chronic persistent hepatitis Shugan Qingre agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) Natrii Sulfas decontamination, pulverized 140-200 mesh sieve and (preferably, pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves);
(4) other residue medical materials are put into marmite together with step (1) (2) made medical material, soak 40 minutes, then big fire is boiled, and a turn little fire decocts 30-60 minute, and (preferred, 40-50 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 45 minutes), filter, collect filtrate;
(5) step (4) remaining filtering residue is decocted with water 30 minutes, filter, collect filtrate, merge twice filtrate, add in filtrate, stir evenly step (3) made powder, heating is concentrated into thick paste, obtains unguentum.
6. the preparation method of chronic persistent hepatitis Shugan Qingre agent unguentum as claimed in claim 5, it is characterized in that, the relative density of step (5) thick paste is 1.20-1.32(50 DEG C) (preferred, relative density is 1.22-1.30(50 DEG C); Be more preferably, relative density is 1.26(50 DEG C)).
7. the chronic persistent hepatitis Shugan Qingre agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) be placed in pot by Maifanitum, add water, boil 20 minutes, it is wooden pacifically then to put into clean Herba Epimedii, Cacumen Securinegae Suffruticosae, Herba Scutellariae Barbatae, Herba Pyrolae, and little fire decocts 20-40 minute, and (preferred, 25-35 minute decocted by little fire; Be more preferably, little fire decocts 30 minutes), filter, collect filtrate, concentrated, dry;
(4) other residue medical materials are pulverized 120-160 mesh sieve (preferred, pulverized 140 mesh sieves) together with step (1) (2) made medical material and the made dry thing of step (3), then added water, generally make ball.
8. the preparation method of chronic persistent hepatitis Shugan Qingre agent pill as claimed in claim 7, it is characterized in that, step (3) amount of water is total quality of medicinal material 6 times.
9. the chronic persistent hepatitis Shugan Qingre agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Radix Curcumae to clean, saturating with water logging 4 one-tenth, pull out, be placed in pot and add water with Radix Glycyrrhizae with boiling 20-30 minute (preferably, with boiling 22-28 minute; Be more preferably, with boiling 25 minutes), take out, dry;
(2) cleaned by Radix Paeoniae Alba decontamination, add cooked Mel and boiled water, mix thoroughly, slightly vexed, put in pot and fry to tack-free, taking-up is dried in the air cool;
(3) be placed in pot by Maifanitum, add water, boil 20 minutes, it is wooden pacifically then to put into clean Herba Epimedii, Cacumen Securinegae Suffruticosae, Herba Scutellariae Barbatae, Herba Pyrolae, and little fire decocts 20-40 minute, and (preferred, 25-35 minute decocted by little fire; Be more preferably, little fire decocts 30 minutes), filter, collect filtrate, concentrated, dry;
(4) by other residue medical material and step (1) (2) made medical material, and the made dry thing of step (3) pulverized 120-160 mesh sieve (preferred, to pulverize 140 mesh sieves) together, and add starch slurry soft material, granulate, dry, granulate, tabletting, obtains tablet.
10. the preparation method of chronic persistent hepatitis Shugan Qingre agent tablet as claimed in claim 9, is characterized in that, the temperature that step (4) is dried is 60-80 DEG C (preferred, the temperature of oven dry is 70 DEG C).
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| GB2557741B (en) * | 2015-05-20 | 2020-03-04 | Golden Health Guangdong Biotechnology Co Ltd | Icariside compound, preperation method thereof, and application thereof |
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Application publication date: 20150408 |