CN110841038A - Medicine for treating mastitis and hyperplasia of mammary glands and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating mastitis and hyperplasia of mammary glands and a preparation method thereof, and the medicament is mainly prepared from raw material medicaments such as gentian, radix bupleuri, rhizoma alismatis, semen plantaginis, radix rehmanniae, angelica, scutellaria, liquorice, radix paeoniae rubra, selfheal spike, coptis chinensis, honeysuckle, fructus forsythiae and safflower according to a certain weight ratio.

Description

Medicine for treating mastitis and hyperplasia of mammary glands and preparation method thereof

Technical Field

The invention relates to a medicament for treating mastitis and hyperplasia of mammary glands, and belongs to the field of traditional Chinese medicines.

Background

Mastitis is an inflammatory disease of mammary gland, is often seen in women who have grown up children, has an influence on the physical health of women, and also has an influence on babies who need to take milk, and clinically typical symptoms of mastitis are local red swelling, heat and pain, and generally are local skin redness of mammary gland at the initial stage, so that mammary tissue edema with tenderness occurs. In severe cases, abscess is formed, if the treatment is not timely performed, inflammation will spread to surrounding tissues, even the abscess is broken, pus is generated, and general poisoning symptoms such as high fever, chill and the like often occur in case of illness. The common manifestations of hyperplasia of mammary glands are chest pain, mass in the breast and increased pain during menstruation. Western medicine treatment mostly adopts antibiotics, penicillin and cephalosporins, but the medicines have large side effects and are easy to cause allergic symptoms.

Disclosure of Invention

Therefore, people have great expectation and need for traditional Chinese medicine for treating mastitis and hyperplasia of mammary glands, and no report about the medicine of the invention is found so far. The inventor successfully develops the medicament for treating the mastitis and the hyperplasia of mammary glands through repeated research and test on the basis of the ancestral medical prescription, thereby completing the invention.

The invention aims to provide a medicament for treating mastitis and hyperplasia of mammary glands.

The invention also aims to provide a preparation method of the medicine.

The medicine is prepared by combining gentiana scabra bunge, radix bupleuri, rhizoma alismatis, plantain seed, radix rehmanniae recen, angelica sinensis, scutellaria baicalensis, liquorice, red paeony root, selfheal spike, coptis chinensis, honeysuckle, fructus forsythiae, safflower, peach kernel, rhizoma sparganii, curcuma zedoary, dandelion, bunge corydalis herb, oldenlandia diffusa, achyranthes bidentata, ligusticum wallichii, radix asparagi, radix ophiopogonis and abrus cantoniensis, and the medicines are combined to generate a synergistic effect, so that mastitis and recurrence of mammary gland hyperplasia can be effectively treated. The gentiana is selected because of its bitter and cold nature, enters liver and gallbladder channels, has the functions of purging liver excess fire and removing lower-jiao damp-heat, and treats exuberant liver channel heat, fright Epilepsy mania, Japanese encephalitis, headache, conjunctival congestion, pharyngalgia, jaundice, dysentery, carbuncle swelling, sore and ulcer, scrotal swelling and pain, and pudendum pruritus. The choice of Bupleurum root is due to its bitter and slightly cold nature, entering liver and gallbladder meridians. Harmonize Shaoyang, defervesce and soothe the liver, and raise Yang. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis. Rhizoma alismatis is selected because of its sweet and cold nature and flavor, enters bladder channel, has the functions of promoting diuresis, excreting dampness and clearing heat, and is used for treating dysuresia, edema, anal fullness, vomiting, diarrhea, phlegm and fluid retention, beriberi, gonorrhea and hematuria. Semen plantaginis is selected because of its sweet and cold nature, enters kidney and bladder channels, has the functions of promoting diuresis, clearing heat, improving eyesight and eliminating phlegm, and is used for treating dysuria, stranguria with turbid urine, leucorrhea, hematuria, summer-heat dampness dysentery, cough with excessive phlegm, damp arthralgia and conjunctival congestion nebula. The selected raw rehmannia root has sweet and cold nature and taste, and has the functions of clearing heat, cooling blood, nourishing yin and promoting fluid production, and is used for treating fever polydipsia, yin deficiency internal heat, bone steaming and fatigue heat, internal heat diabetes, hematemesis, epistaxis, macula and eruption. The angelica is selected because of its sweet and pungent nature and warm nature, enters heart, liver and spleen channels, has the functions of tonifying blood and regulating blood, regulating menstruation and relieving pain, and moistening dryness and lubricating intestines, and is used for treating irregular menstruation, amenorrhea and abdominal pain, abdominal mass, metrorrhagia, blood deficiency and headache, dizziness, flaccidity and paralysis, intestinal dryness and difficulty, severe after dysentery, carbuncle, sore and ulcer, incised wound and traumatic injury. The scutellaria is selected because of its bitter and cold nature, enters heart, lung, gallbladder and large intestine channels, has the functions of purging excess fire, eliminating dampness and heat, stopping bleeding and preventing abortion, and is used for treating high fever, polydipsia and cough with lung heat. The liquorice is selected because of its sweet and mild nature, enters spleen, stomach and lung channels, has the functions of regulating the middle warmer and relieving urgency, moistening lung, detoxifying and harmonizing the other drugs, and is used for treating weakness of spleen and stomach, anorexia, abdominal pain and loose stool, fatigue and fever, consumptive lung disease and cough, palpitation, acute carbuncle, and is used for treating swollen sore throat, peptic ulcer, carbuncle, sore and ulcer, drug toxicity removal and food poisoning in unprocessed use. Radix Paeoniae Rubra is selected because it is bitter in taste and slightly cold, enters liver meridian, has functions of clearing heat and cooling blood, removing blood stasis and relieving pain, and is used for treating mania due to warm toxin, hematemesis and epistaxis, conjunctival congestion and swelling pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, Epilepsy abdominal pain, traumatic injury, carbuncle, swelling, sore and ulcer. The summer-heat ball is selected because of its bitter, pungent and cold nature, enters liver and gallbladder channels, has the functions of clearing liver heat, dissipating stagnation and reducing blood pressure, and is used for treating diseases such as liver fire flaming up, conjunctival congestion and swelling pain, mastitis, carbuncle, sore and toxic swelling, scrofula and thyromegaly caused by stagnation of phlegm-fire, hypertension and the like. The coptis root is selected because of its bitter and cold nature, enters heart, liver, stomach and large intestine channels, has the functions of purging fire, drying dampness, detoxifying and killing parasites, and has the functions of purging fire, eliminating dampness and killing parasites when being treated, and has the functions of removing heat toxin, typhoid fever, excessive heat and vexation, fullness and vomiting, bacillary dysentery, heat diarrhea and abdominal pain, phthisis, vomiting, epistaxis, hematochezia, diabetes, malnutritional stagnation, ascariasis, whooping cough, sore throat, hot eyes, aphtha, carbuncle and sore toxin, eczema and soup fire scald. Honeysuckle is selected because of its sweet and cold nature, enters lung and stomach channels, has the functions of clearing heat and detoxifying, and is used for treating epidemic febrile disease, fever, heat-toxin bloody dysentery, carbuncle and ulcer, pyogenic infections, scrofula and anal fistula. Fructus forsythiae is selected because of its bitter and cool nature, enters heart, liver and gallbladder channels, has the effects of clearing heat, removing toxicity, resolving masses, relieving swelling, and treating warm heat, erysipelas, macula, carbuncle and ulcer pyogenic infections, scrofula and urinary stranguria. Safflower is selected because of its pungent and warm nature, enters heart and liver meridians, has the functions of promoting blood circulation, dredging meridian, removing blood stasis and relieving pain, and is used for treating amenorrhea, abdominal mass, dystocia, dead fetus, postpartum lochiorrhea, blood stasis pain, carbuncle swelling and traumatic injury. Peach kernel is selected because of its bitter and sweet taste, is neutral, enters heart, liver and large intestine channels, has the functions of breaking blood and removing stasis, moistening dryness and smoothing channels, and is used for treating amenorrhea, abdominal mass, heat disease blood accumulation, blood arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis and constipation due to blood dryness. The rhizoma sparganii is selected because of its bitter and pungent taste, is mild, enters liver and spleen channels, has the functions of breaking blood, promoting qi circulation, removing food retention and relieving pain, and is used for treating abdominal mass, qi and blood stagnation, heart and abdominal pain, hypochondrium distending pain, amenorrhea, postpartum blood stasis and abdominal pain, traumatic injury, sore and hard swelling. The zedoary is selected because of its pungent, bitter and warm nature, enters liver and spleen channels, has the functions of promoting qi circulation, removing blood stasis, removing food retention and relieving pain, and is used for treating abdominal mass, amenorrhea due to blood stasis, food retention and distending pain, traumatic injury and swelling pain, and early stage cervical cancer. The dandelion is selected because of bitter and sweet taste and cold nature, enters liver and stomach channels, has the functions of clearing heat and detoxicating, inducing diuresis and resolving masses, and is used for treating acute mastitis, lymphadenitis, scrofula, furunculosis, acute conjunctivitis, common cold and fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis and urinary tract infection. Herba Violae is selected because of its bitter and cold nature, enters heart and liver meridians, has the functions of clearing heat and promoting diuresis, and removing toxicity and relieving swelling, and is used for treating furuncle, carbuncle and swelling, scrofula, jaundice, dysentery, diarrhea, conjunctival congestion, sore throat and snake bite. The oldenlandia diffusa is selected because of bitter and sweet and cold nature, enters heart, liver and spleen meridians, has the functions of clearing heat, promoting diuresis and detoxifying, and is used for treating lung heat cough and asthma, tonsillitis, sphagitis, appendicitis, dysentery, jaundice, pelvic inflammation, adnexitis, carbuncle swelling and furuncle and venomous snake bite. The achyranthes root is selected because of its sweet and bitter taste, neutral, enters liver and kidney channels, is used for removing blood stasis, eliminating carbuncle and swelling, treating gonorrhea, hematuria, amenorrhea, abdominal mass, dystocia, retained afterbirth, postpartum blood stasis and abdominal pain, pharyngitis, carbuncle and swelling, traumatic injury, nourishing liver and kidney, strengthening bones and muscles, treating waist and knee osteodynia, four-fat spasm and flaccidity and arthralgia. Rhizoma Ligustici Chuanxiong is selected because of its pungent and warm nature, enters liver and gallbladder channels, has effects of activating qi-flowing, resolving stagnation, dispelling pathogenic wind, eliminating dampness, promoting blood circulation and relieving pain, and can be used for treating wind cold, headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal blood stasis, pain, carbuncle, cellulitis, skin ulcer, etc. The radix asparagi is selected because of its sweet and bitter taste and cold nature, enters lung and kidney channels, has the functions of nourishing yin, moistening dryness, clearing lung-heat and reducing pathogenic fire, and is used for treating yin deficiency fever, cough and hematemesis, consumptive lung disease, pulmonary abscess, swollen and sore throat, diabetes and constipation. The radix ophiopogonis is selected because of sweet, slightly bitter and cold nature, enters lung, stomach and heart channels, has the functions of nourishing yin, moistening lung, clearing heart, relieving restlessness, benefiting stomach and promoting fluid production, and is used for treating dry cough due to lung dryness, hematemesis, hemoptysis, consumptive lung disease, pulmonary abscess, consumptive disease, dysphoria with smothery sensation, thirst, heat disease, body fluid consumption, dry throat and mouth, and constipation. The abrus cantoniensis hance is selected because of sweet and cool nature and has the functions of clearing heat and detoxicating, soothing liver and removing blood stasis, and is used for treating icterohepatitis, stomachache, acute mastitis, scrofula and blood stasis and pain caused by traumatic injury.

The dosage of the medicine is obtained by repeated tests on the basis of the ancestral medical prescription of the inventor, and the dosage of each medicine is within the following weight range, so that the medicine has better curative effect:

45-55 g of gentiana scabra bunge, 50-60 g of radix bupleuri, 35-45 g of rhizoma alismatis, 35-45 g of plantain seed, 45-55 g of radix rehmanniae recen, 45-55 g of angelica sinensis, 45-55 g of scutellaria baicalensis, 25-35 g of liquorice, 55-65 g of red peony root, 45-55 g of selfheal spike, 35-45 g of coptis chinensis, 45-55 g of honeysuckle, 45-55 g of fructus forsythiae, 25-35 g of safflower, 45-55 g of peach kernel, 45-55 g of rhizoma sparganii, 45-55 g of curcuma zedoary, 45-55 g of dandelion, 45-55 g of bunge corydalis herb, 45-55 g of oldenlandia diffusa, 45-55 g of achyranthes bidentata, 25-35 g of ligusticum wallichii, 45-55 g of radix asparagi, 45-55 g of.

The preferred amounts are:

50 g of gentiana scabra bunge, 60 g of radix bupleuri, 40 g of rhizoma alismatis, 40 g of plantain seed, 50 g of radix rehmanniae recen, 50 g of angelica sinensis, 50 g of scutellaria baicalensis, 30 g of liquorice, 60 g of red paeony root, 50 g of selfheal spike, 40 g of coptis chinensis, 50 g of honeysuckle, 50 g of fructus forsythiae, 30 g of safflower, 50 g of peach kernel, 50 g of rhizoma sparganii, 50 g of curcuma zedoary, 50 g of dandelion, 50 g of bunge corydalis herb, 50 g of oldenlandia diffusa, 50 g of achyranthes bidentata, 30 g of ligusticum wallichii, 50 g of radix asparagi

The preparation method of the medicine of the invention comprises the following steps:

first, prepare material

1. Gentian: removing impurities, removing residual stem, cleaning, moistening, cutting, and sun drying;

2. bupleurum root: removing impurities, removing residual stems, cleaning silt, taking out, moistening, timely slicing, and sun drying;

3. rhizoma alismatis: removing impurities, grading, soaking in water until the water content reaches eight percent, taking out, cooling, moistening until the humidity inside and outside is uniform, slicing, and sun drying;

4. plantain seed: removing impurities, screening out mud scraps and empty particles;

5. dried rehmannia root: removing impurities, cleaning, slightly moistening, slicing into thick pieces, drying, and sieving to remove debris;

6. chinese angelica: removing impurities, cleaning, moistening, slightly drying in the air, slicing, and drying in the sun;

7. scutellaria baicalensis: removing impurities, removing residual stem, soaking in cold water or boiling water, taking out, slicing, and sun drying;

8. licorice root: removing impurities, cleaning, soaking in water until eighty percent of the total weight is reached, taking out, moistening, slicing, and air drying;

9. red peony root: taking raw medicinal materials, removing impurities, grading the raw medicinal materials according to size, cleaning, moistening thoroughly, slicing, drying, and screening to remove scraps;

10. summer withered ball: removing impurities, and drying in the sun;

11. coptis chinensis: removing impurities, cleaning sand, moistening, slicing, and drying in the shade;

12. honeysuckle flower: screening out silt and picking up impurities;

13. fructus forsythiae: sorting out impurities, rubbing the impurities open, and removing branches and stalks;

14. safflower: removing impurities, removing stem leaves and pedicles, and sun drying;

15. peach kernel: removing impurities from hard shell, boiling in boiling water until the outer skin is slightly wrinkled, taking out, soaking in cold water, removing seed coat by rubbing, sun drying, and cleaning;

16. frying the rhizoma sparganii: putting wheat bran into a pot, frying until smoke is produced, adding the triangular pieces, and frying until the mixture is yellow, wherein 100kg of rhizoma sparganii is added, and 10kg of wheat bran is used;

17. vinegar-processed curcuma zedoary: soaking clean Curcumae rhizoma in rice vinegar, decocting with slow fire until the vinegar juice is absorbed completely and no white core exists, taking out, slightly drying, slicing into thick pieces, drying, and adding rice vinegar 20 kg per Curcumae rhizoma 100 kg;

18. dandelion: removing impurities, cleaning soil, cutting into segments, and drying in the sun;

19. corydalis Bungeana (L.) Merr: removing impurities, washing with water to remove soil, cutting, and drying in the sun;

20. herba Hedyotidis Diffusae: taking raw medicinal materials, removing impurities, cleaning with water, slightly airing, cutting into sections, drying, and screening to remove ash and scraps;

21. achyranthes root: removing impurities, cleaning, moistening, softening, removing reed, cutting into segments, and drying in the sun;

22. ligusticum wallichii: removing impurities, separating into large and small pieces, soaking in water, sun drying, moistening, slicing, and drying;

23. radix asparagi: removing impurities, washing with water, moistening until the humidity inside and outside is uniform, cutting into segments, and drying.

24. Radix ophiopogonis: cleaning impurities, soaking in water, taking out, moistening, removing core, cleaning, and sun drying;

25. abrus cantoniensis: cleaning, slicing and drying in the sun.

II, preparation of

1. Putting the processed gentiana scabra bunge, radix bupleuri, rhizoma alismatis, semen plantaginis, radix rehmanniae recen, angelica sinensis, scutellaria baicalensis, liquorice, radix paeoniae rubra, selfheal balls, coptis chinensis, honeysuckle, fructus forsythiae, safflower, peach kernels, rhizoma sparganii, curcuma zedoary, dandelion, bunge corydalis herb, oldenlandia diffusa, achyranthes bidentata, ligusticum wallichii, radix asparagi, radix ophiopogonis and abrus cantoniensis hance into a decocting container, adding water for decocting twice, adding 8 times of water for the first time, soaking for 50 minutes, boiling with strong fire, decocting with slow fire for 40 minutes, and filtering to obtain a first;

2. adding 6 times of water into the filtered residue, boiling with strong fire, decocting with slow fire for 30 minutes, and filtering to obtain a second decoction;

3. mixing the two decoctions, and stirring to obtain antiinflammatory liquid for mammary gland.

In the formula, the dandelion has the functions of clearing away heat and toxic materials, promoting urination and resolving masses, and treating mastitis, and is a monarch drug; the red paeony root has the functions of clearing heat and cooling blood, dissipating blood stasis and relieving pain, the oldenlandia has the functions of clearing heat, promoting diuresis and detoxifying, the two medicines are ministerial medicines, the three medicines play the roles of clearing heat and detoxifying, cooling blood and promoting diuresis, dissipating blood stasis and relieving pain together, the efficacy of treating mastitis is comprehensive, and the main effects of clearing heat and detoxifying, promoting diuresis and resolving masses can be used for treating mastitis; fructus forsythiae has the functions of clearing away heat and toxic materials, eliminating stagnation and relieving swelling, and is used as adjuvant drug; licorice root, radix Glycyrrhizae has the functions of regulating the middle warmer, moistening lung, removing toxicity, and harmonizing the effects of the other drugs, and is a temporary remedy with the rest drugs.

The medicine has the functions of clearing heat and cooling blood, promoting diuresis and removing toxicity, eliminating stagnation and reducing swelling, clearing liver heat and dissipating blood stasis, and is used for treating mastitis and hyperplasia of mammary glands with quick response and no relapse after healing.

The beneficial effects of the medicament of the invention are further illustrated by the following test examples, which include toxicity test reports and clinical observations of animals.

Test example 1 toxicity test report of the drug of the present invention

22 West German rabbits are taken, male and female rabbits are used simultaneously, the weight of the West German rabbits ranges from 2.0 kg to 2.5kg, the West German rabbits are divided into two groups, each group comprises 11 rabbits, the first group is a normal dose test group, the second group is an ultra-constant test group, the mammary gland anti-inflammatory liquid is taken, the normal dose test group is 5ml/kg, the ultra-constant test group is 10ml/kg, the administration mode is gastric perfusion administration, the two times are taken every day for 7 days, the administration reaction is observed every day, the observation result is that the eating activity of the normal dose test group rabbits is normal, after three rabbits in the ultra-constant test group are taken, the feeling is slow, the appetite is reduced, the normal behavior is recovered after the administration is stopped, and the result shows that the medicine has no.

[ test example 2] clinical observation data of the drug of the present invention

1. 22 patients with mastitis, 18 patients with mammary gland hyperplasia are treated in an outpatient clinic, the patients with mastitis are divided into two groups, 11 patients with mastitis are divided into 11 groups, 9 patients with mammary gland hyperplasia are divided into 9 groups, one group is respectively a treatment group, the other group is respectively a treatment control group, the treatment group is orally administered with mammary gland anti-inflammatory liquid, and the control group is orally administered with nodules of breast diminishing tablets.

2. Diagnostic criteria

The main symptoms of mastitis are fever, inflammation focus such as red, swelling, heat, pain, lump and the like on local mammary gland, lump with tenderness and conventional increase of white blood cells. The common manifestations of hyperplasia of mammary glands are chest pain, lump in breast, and aggravation of pain during menstruation.

3. Method of treatment

(1) The mastitis treatment group and the mammary gland hyperplasia treatment group are respectively orally administered with the mammary gland anti-inflammatory liquid 2-3 times a day, one dose is taken every time, one week is a treatment course, and mastitis is continuously taken for 3-4 treatment courses; the capsule is administered for 3-4 treatment courses for treating hyperplasia of mammary glands, and the two control groups are administered orally for 3-4 treatment courses, respectively, three times per day, 5-6 tablets each time, and one week is a treatment course;

(2) when the medicine is taken, the treatment group is combined with diet therapy to enhance the treatment effect of the medicine, and any one of the following diet foods can be selected for matching treatment:

a method 1: poria cocos-chrysanthemum pork soup

Materials: 500 g of lean pork, 30 g of tuckahoe, 5 g of chrysanthemum, 25 g of black sesame, 10 g of dandelion, 5 g of ginger, 3 g of salt, 2 g of monosodium glutamate and 10 g of scallion

The preparation method comprises the following steps:

① cleaning lean meat, cutting into pieces, quickly boiling in water, cleaning Poria, slicing, cleaning flos Chrysanthemi, semen Sesami nigrum and herba Taraxaci, oven drying semen Sesami nigrum, and parching;

② placing lean meat, Poria, flos Chrysanthemi, herba Taraxaci, rhizoma Zingiberis recens, and herba Alii Fistulosi in stewpan, adding clear water, and stewing for 2 hr;

③ taking lean pork out, adding salt and monosodium glutamate, spreading semen Sesami nigrum, and mixing with soy sauce for four times, once daily, and three weeks;

and 2, a method: lotus root, red bean and shredded ginger soup

Materials: 500 g of pork lean meat, 100 g of lotus root, 20 g of small red bean, 10 g of lucid ganoderma, 5 g of platycodon root, 10 g of dandelion, 10 g of shredded ginger, 10 g of chopped scallion, 5 g of salt, 3 g of chicken essence and 2.5 g of sesame oil

The preparation method comprises the following steps:

① cleaning lean pork, cutting into pieces, removing nodes and skin of rhizoma Nelumbinis, cleaning, cutting into segments, removing impurities from semen Phaseoli, cleaning Ganoderma, radix Platycodonis, and herba Taraxaci, wrapping with gauze, and tightening;

② adding lean pork, rhizoma Nelumbinis, semen Phaseoli, rhizoma Zingiberis recens, and herba Alii Fistulosi powder into a pan, adding water, boiling with strong fire, adding yarn package of Ganoderma, radix Platycodi, and herba Taraxaci, and decocting with slow fire for 70 min;

③ discarding the bag, adding salt, chicken essence, and sesame oil, and blending for four times for treating mastitis and hyperplasia of mammary glands once per day for 3 weeks;

and (3) a method: couch grass root-honeysuckle flower-pig's feet soup

Materials: honeysuckle, Chinese violet, dandelion, dahurian angelica root, cogongrass rhizome each 15 g, glossy ganoderma 10 g, 2 pig's feet, salt 3 g, shredded ginger 5 g, shallot 5 g

The preparation method comprises the following steps:

① washing ungula Sus domestica, cutting into pieces, and quick-boiling in water;

② cleaning flos Lonicerae, herba Violae, herba Taraxaci, radix Angelicae Dahuricae, rhizoma Imperatae, and Ganoderma, packaging into gauze bag, and tightening;

③ adding water into iron pan, adding ungula Sus Domestica and gauze bag, adding salt, rhizoma Zingiberis recens and herba Alii Fistulosi powder, boiling with strong fire, decocting with slow fire for 70 min, taking out the bag, discarding, and eating twice, and once daily for mastitis and hyperplasia of mammary glands for 3 weeks.

4. Criteria for efficacy assessment

The effect is shown: the symptoms of red, swelling, heat, pain and lump of mastitis and hyperplasia of mammary glands disappear, and breasts recover and are healed;

improvement: the symptoms of red, swollen, hot and painful mastitis are improved, and the mass is gradually reduced; the chest pain of the hyperplasia of mammary glands is improved, and the lump in the breast gradually disappears;

and (4) invalidation: the improvement standard can not be achieved.

5. Therapeutic results

The mastitis treatment group takes the mammary gland anti-inflammatory liquid orally three times a day, one dose is taken every time, 3-4 treatment courses are taken continuously and are matched with food therapy, the effect is 9 persons, the improvement is 2 persons, and the total effective rate is 100%; the mastitis control group orally takes the nodules of breast to eliminate tablets for 3 courses of treatment, the result is obvious and effective for 6 persons, improves for 3 persons, and is ineffective for 2 persons, and the total effective rate is 75%. The mammary gland anti-inflammatory liquid is orally taken by a mammary gland hyperplasia treatment group for 4 courses of treatment, the result shows that 7 persons are effective, 1 person is improved, 1 person is ineffective, and the total effective rate is 88.89%; the mammary gland hyperplasia control group orally takes the mammary nodule eliminating tablet for 4 courses of treatment, the result is obvious to 5 persons, the improvement is 2 persons, the ineffectiveness is 2 persons, and the total effective rate is 77.78%.

Claims (4)

1. A medicament for treating mastitis and hyperplasia of mammary glands is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in weight range:

45-55 g of gentiana scabra bunge, 50-60 g of radix bupleuri, 35-45 g of rhizoma alismatis, 35-45 g of plantain seed, 45-55 g of radix rehmanniae recen, 45-55 g of angelica sinensis, 45-55 g of scutellaria baicalensis, 25-35 g of liquorice, 55-65 g of red peony root, 45-55 g of selfheal spike, 35-45 g of coptis chinensis, 45-55 g of honeysuckle, 45-55 g of fructus forsythiae, 25-35 g of safflower, 45-55 g of peach kernel, 45-55 g of rhizoma sparganii, 45-55 g of curcuma zedoary, 45-55 g of dandelion, 45-55 g of bunge corydalis herb, 45-55 g of oldenlandia diffusa, 45-55 g of achyranthes bidentata, 25-35 g of ligusticum wallichii, 45-55 g of radix asparagi, 45-55 g of.

2. The medicament of claim 1, wherein the dosage of each raw material medicament is as follows:

50 g of gentiana scabra bunge, 60 g of radix bupleuri, 40 g of rhizoma alismatis, 40 g of plantain seed, 50 g of radix rehmanniae recen, 50 g of angelica sinensis, 50 g of scutellaria baicalensis, 30 g of liquorice, 60 g of red paeony root, 50 g of selfheal spike, 40 g of coptis chinensis, 50 g of honeysuckle, 50 g of fructus forsythiae, 30 g of safflower, 50 g of peach kernel, 50 g of rhizoma sparganii, 50 g of curcuma zedoary, 50 g of dandelion, 50 g of bunge corydalis herb, 50 g of oldenlandia diffusa, 50 g of achyranthes bidentata, 30 g of ligusticum wallichii, 50 g of radix asparagi.

3. The process for the preparation of a medicament according to claim 1 or 2, characterized in that: it comprises the following steps:

(I) preparing materials

(1) Gentian: removing impurities, removing residual stem, cleaning, moistening, cutting, and sun drying;

(2) bupleurum root: removing impurities, removing residual stems, cleaning silt, taking out, moistening, timely slicing, and sun drying;

(3) rhizoma alismatis: removing impurities, grading, soaking in water until the water content reaches eight percent, taking out, cooling, moistening until the humidity inside and outside is uniform, slicing, and sun drying;

(4) plantain seed: removing impurities, screening out mud scraps and empty particles;

(5) dried rehmannia root: removing impurities, cleaning, slightly moistening, slicing into thick pieces, drying, and sieving to remove debris;

(6) chinese angelica: removing impurities, cleaning, moistening, slightly drying in the air, slicing, and drying in the sun;

(7) scutellaria baicalensis: removing impurities, removing residual stem, soaking in cold water or boiling water, taking out, slicing, and sun drying;

(8) licorice root: removing impurities, cleaning, soaking in water until eighty percent of the total weight is reached, taking out, moistening, slicing, and air drying;

(9) red peony root: taking raw medicinal materials, removing impurities, grading the raw medicinal materials according to size, cleaning, moistening thoroughly, slicing, drying, and screening to remove scraps;

(10) summer withered ball: removing impurities, and drying in the sun;

(11) coptis chinensis: removing impurities, cleaning sand, moistening, slicing, and drying in the shade;

(12) honeysuckle flower: screening out silt and picking up impurities;

(13) fructus forsythiae: sorting out impurities, rubbing the impurities open, and removing branches and stalks;

(14) safflower: removing impurities, removing stem leaves and pedicles, and sun drying;

(15) peach kernel: removing impurities from hard shell, boiling in boiling water until the outer skin is slightly wrinkled, taking out, soaking in cold water, removing seed coat by rubbing, sun drying, and cleaning;

(16) frying the rhizoma sparganii: putting wheat bran into a pot, frying until smoke is produced, adding the triangular pieces, and frying until the mixture is yellow, wherein 100kg of rhizoma sparganii is added, and 10kg of wheat bran is used;

(17) vinegar-processed curcuma zedoary: soaking clean Curcumae rhizoma in rice vinegar, decocting with slow fire until the vinegar juice is absorbed completely and no white core exists, taking out, slightly drying, slicing into thick pieces, drying, and adding rice vinegar 20 kg per Curcumae rhizoma 100 kg;

(18) dandelion: removing impurities, cleaning soil, cutting into segments, and drying in the sun;

(19) corydalis Bungeana (L.) Merr: removing impurities, washing with water to remove soil, cutting, and drying in the sun;

(20) herba Hedyotidis Diffusae: taking raw medicinal materials, removing impurities, cleaning with water, slightly airing, cutting into sections, drying, and screening to remove ash and scraps;

(21) achyranthes root: removing impurities, cleaning, moistening, softening, removing reed, cutting into segments, and drying in the sun;

(22) ligusticum wallichii: removing impurities, separating into large and small pieces, soaking in water, sun drying, moistening, slicing, and drying;

(23) radix asparagi: removing impurities, washing with water, moistening until the humidity inside and outside is uniform, cutting into segments, and drying.

(24) Radix ophiopogonis: cleaning impurities, soaking in water, taking out, moistening, removing core, cleaning, and sun drying;

(25) abrus cantoniensis: cleaning, slicing and drying in the sun;

(II) preparation

(1) Putting the processed gentiana scabra bunge, radix bupleuri, rhizoma alismatis, semen plantaginis, radix rehmanniae recen, angelica sinensis, scutellaria baicalensis, liquorice, radix paeoniae rubra, selfheal balls, coptis chinensis, honeysuckle, fructus forsythiae, safflower, peach kernels, rhizoma sparganii, curcuma zedoary, dandelion, bunge corydalis herb, oldenlandia diffusa, achyranthes bidentata, ligusticum wallichii, radix asparagi, radix ophiopogonis and abrus cantoniensis hance into a decocting container, adding water for decocting twice, adding 8 times of water for the first time, soaking for 50 minutes, boiling with strong fire, decocting with slow fire for 40 minutes, and filtering to obtain a first;

(2) adding 6 times of water into the filtered residue, boiling with strong fire, decocting with slow fire for 30 minutes, and filtering to obtain a second decoction;

(3) mixing the two decoctions, and stirring to obtain antiinflammatory liquid for mammary gland.

4. The medicament according to claim 1 or 2, characterized in that: the food also comprises a dietary recipe, and any one of the following recipes is taken for eating while the medicine is taken:

a method 1: poria cocos-chrysanthemum pork soup

Materials: 500 g of lean pork, 30 g of tuckahoe, 5 g of chrysanthemum, 25 g of black sesame, 10 g of dandelion, 5 g of ginger, 3 g of salt, 2 g of monosodium glutamate and 10 g of scallion

The preparation method comprises the following steps:

① cleaning lean meat, cutting into pieces, quickly boiling in water, cleaning Poria, slicing, cleaning flos Chrysanthemi, semen Sesami nigrum and herba Taraxaci, oven drying semen Sesami nigrum, and parching;

② placing lean meat, Poria, flos Chrysanthemi, herba Taraxaci, rhizoma Zingiberis recens, and herba Alii Fistulosi in stewpan, adding clear water, and stewing for 2 hr;

③ taking out lean pork, adding salt and monosodium glutamate, spreading semen Sesami nigrum, and adding soy sauce;

and 2, a method: lotus root, red bean and shredded ginger soup

Materials: 500 g of pork lean meat, 100 g of lotus root, 20 g of small red bean, 10 g of lucid ganoderma, 5 g of platycodon root, 10 g of dandelion, 10 g of shredded ginger, 10 g of chopped scallion, 5 g of salt, 3 g of chicken essence and 2.5 g of sesame oil

The preparation method comprises the following steps:

① cleaning lean pork, cutting into pieces, removing nodes and skin of rhizoma Nelumbinis, cleaning, cutting into segments, removing impurities from semen Phaseoli, cleaning Ganoderma, radix Platycodonis, and herba Taraxaci, wrapping with gauze, and tightening;

② adding lean pork, rhizoma Nelumbinis, semen Phaseoli, rhizoma Zingiberis recens, and herba Alii Fistulosi powder into a pan, adding water, boiling with strong fire, adding yarn package of Ganoderma, radix Platycodi, and herba Taraxaci, and decocting with slow fire for 70 min;

③ discarding the added yarn bag containing Ganoderma, radix Platycodi, and herba Taraxaci, adding salt, chicken essence, and sesame oil, and blending to obtain rhizoma Nelumbinis, semen Phaseoli, and rhizoma Zingiberis recens shred soup;

and (3) a method: couch grass root-honeysuckle flower-pig's feet soup

Materials: honeysuckle, Chinese violet, dandelion, dahurian angelica root, cogongrass rhizome each 15 g, glossy ganoderma 10 g, 2 pig's feet, salt 3 g, shredded ginger 5 g, shallot 5 g

The preparation method comprises the following steps:

① washing ungula Sus domestica, cutting into pieces, and quick-boiling in water;

② cleaning flos Lonicerae, herba Violae, herba Taraxaci, radix Angelicae Dahuricae, rhizoma Imperatae, and Ganoderma, packaging into gauze bag, and tightening;

③ adding water into iron pan, adding ungula Sus domestica and gauze bag, adding salt, rhizoma Zingiberis recens and herba Alii Fistulosi powder, boiling with strong fire, decocting with slow fire for 70 min, taking out the bag, and discarding to obtain decoction.