CN105362556A - Traditional Chinese medicine preparation for preventing and treating leukemia and preparing method thereof - Google Patents

Traditional Chinese medicine preparation for preventing and treating leukemia and preparing method thereof Download PDF

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CN105362556A
CN105362556A CN201510866495.0A CN201510866495A CN105362556A CN 105362556 A CN105362556 A CN 105362556A CN 201510866495 A CN201510866495 A CN 201510866495A CN 105362556 A CN105362556 A CN 105362556A
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herba
radix
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Abstract

The invention discloses a traditional Chinese medicine preparation for preventing and treating leukemia and a preparing method thereof. The traditional Chinese medicine preparation is prepared from, by weight, 7-12 parts of radix pseudostellariae, 4-10 parts of radix acanthopanacis senticosi, 9-13 parts of sedum stellariifolium, 6-12 parts of fructus livistonae chinensis, 8-14 parts of herba andrographitis, 6-10 parts of rhizoma menispermi, 8-13 parts of caulis spatholobi, 7-14 parts of patrinia scaniosaefolia, 6-13 parts of oldenlandia diffusa, 5-11 parts of cyathula prostrata, 7-11 parts of cistanche salsa, 5-12 parts of phyllagathis cavaleriei, 6-11 parts of angelica sinensis and 3-8 parts of elatostema stewardii. The traditional Chinese medicine preparation is safe, free of toxic and side effects, free of drug resistance, and capable of adjusting body immune level, promoting body immune function recovering and completely killing leukemia cells in the body of a patient so as to prevent the relapse of the leukemia.

Description

The leukemic Chinese medicine preparation of a kind of control and method for making
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the leukemic Chinese medicine preparation of a kind of control and method for making.
Background technology
Leukemia is a class hematopoietic stem cell malignant clone disease.Clonal leukaemia breeds accumulation in a large number because of mechanism such as proliferation out of control, dysdifferentiation, apoptosis are obstructed in bone marrow and other hemopoietic tissue, and infiltrates its hetero-organization and organ, and normal hematopoiesis is suppressed simultaneously.Clinical visible anemia in various degree, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pain.The cause of disease: 1. viral factor.RNA viruses has been affirmed in the leukemia effect that causes of the animals such as Mus, cat, chicken and cattle, and this kind of virogenetic leukemia belongs to T cell type more.2. chemical factor.Some chemical substances have leukemogenic effect.Crowd's leukemia incidence rate of contact benzene and its derivative is higher than population.Also nitrosamines material, Phenylbutazone and derivant, chloromycetin etc. is had to bring out leukemic report.Some antitumor cell cytotoxic drug, as chlormethine, cyclophosphamide, procarbazine, VP16, VM26 etc. cause leukemia effect.3. radiate factor.Evidence show, various ionizing radiation can cause human leukemia.The leukemic dosage depending on absorption of human body radiation, whole health or body part all can bring out leukemia after being subject to median dose or high dose radiation.Low dose radiation can leukemogenesis still uncertain.Frequent contact radiation material (as cobalt-60) person leukemia sickness rate obviously increases.Heavy dose of radiation diagnostic and treatment can make leukemia incidence rate increase.4. inherited genetic factors.There is crowd's leukemia sickness rate of chromosomal aberration higher than normal person.
Child and a lot of disease of teenager acute leukemia hurried.Common onset symptoms comprises heating, Progressive symmetric erythrokeratodermia anemia, significant bleeding tendency or bone joint pain etc.The slow person of onset is with old and part Young patients is in the majority, and the state of an illness is in progress gradually.In addition, small number of patients can be twitched, blind, toothache, swelling and aching of gum, pericardial effusion, two paraplela inferior etc. are onset symptoms.1. generate heat.Be one of modal symptom of leukemia, show as heating in various degree and pattern of fever.The main cause of heating infects, and wherein the most common with angina, stomatitis, perianal infection, pneumonia, tonsillitis, gingivitis, perianal abscess etc. are also more common.Ear's inflammation, enteritis, carbuncle, pyelonephritis etc. also show, and severe patient septicemia, pyemia etc. can occur.Heating also can be the symptom of acute leukemia itself, and without any infection sign.2. infect.Pathogen is common with antibacterial.3. hemorrhage.Bleeding part can throughout whole body, the most common with skin, gingiva, nasal bleeding, also can have the hemorrhage and internal organs massive hemorrhage such as intracranial, digestive tract, respiratory tract of retina, in ear.Feminine menstrual is too much also more common, can be onset symptoms.4. anemia.Can occur in early days, minority case can before making a definite diagnosis several months or several years first there is myelodysplastic syndrome (MDS), later developing deeply becomes leukemia.Patient often with weak, pale complexion, cardiopalmus, breathe hard, the symptom such as lower limbs edema.5. bone and arthralgia.The leukemic infiltration of bone and periosteum causes osteodynia, can be limbs or back diffusivity pain, also can be confined to arthralgia, often cause moving difficulty.6. liver spleen and lymphadenectasis.Be common with light, moderate hepatosplenomegaly.7. central nervous system leukemia (CNSL).Infiltrating sites mostly occurs at arachnoidea, cerebral dura mater, is secondly brain essence, choroid or cranial nerve.Serious symptom person has headache, vomiting, stiffness of the nape, papilloedema, even twitches, the typical performance of the increased intracranial pressure such as stupor, can similar intracranial hemorrhage, and the lighter only tells slight headache, dizziness.Cranial nerve (VI, VII pair of cranial nerve are main) is got involved and can be occurred visual disorder and facial paralysis etc.8. its hetero-organization and organ infiltration.9. the symptom of chronic myelocytic leukemia.Onset is slow, early stage normal no conscious sympton, how because of physical examination or because of just discovery hemogram abnormity or splenomegaly and make a definite diagnosis when other diseases is sought medical advice.Along with PD, weak, low grade fever, hyperhidrosis or night sweat can be there is, the old hypermetabolic performance such as lose weight.The symptom such as glutted after upper left abdomen falling inflation, food is felt due to splenomegaly.What give prominence to the most during inspection is splenomegaly, reaches umbilical plane when often seeking medical advice.
Application publication number CN103550507A(application number 201310532357.X) Chinese patent literature disclose one and treat leukemic Chinese medicine, it is made up of the raw material of following weight proportioning: the Radix Rehmanniae 12 ~ 18, Spica Prunellae 15 ~ 25, Herba Hedyotidis Diffusae 30 ~ 40, Cortex Moutan 12 ~ 20, Cornu Bubali 50 ~ 60, Radix Scrophulariae 40 ~ 50, Radix Isatidis 30 ~ 40, Fructus Gardeniae 5 ~ 12, Radix Codonopsis 8 ~ 15, Rhizoma Polygonati 4 ~ 10, Fructus Psoraleae 10 ~ 20.Application publication number CN101979013A(application number 201010544963.X) Chinese patent literature disclose one and treat leukemic Chinese medicine, its Chinese medicinal components and weight portion be, the Radix Astragali 4-10 parts; Radix Angelicae Sinensis 2-8 parts; 4-10 parts, Colla Corii Asini; Radix Salviae Miltiorrhizae 3-9 parts; Radix Codonopsis 8-15 parts; 8-15 parts, Radix Rehmanniae Preparata.Application publication number CN104706794A(application number 201310668880.5) Chinese patent literature disclose one and treat leukemic Chinese medicine formula, this kind of leukemic Chinese medicine formula for the treatment of, by Radix Dipsaci 40 grams, the Radix Astragali 40 grams, Radix Codonopsis 40 grams, Radix Schisandrae Bicoloris 40 grams, Radix Paeoniae Alba (parched) 40 grams, Radix Polygoni Multiflori Preparata 40 grams, Fructus Psoraleae 40 grams, Cortex Eucommiae (parched) 40 grams, Massa Medicata Fermentata 40 grams, Radix Angelicae Sinensis 40 grams, 40 grams, Radix Rehmanniae Preparata, Caulis Spatholobi 40 grams, Radix Achyranthis Bidentatae 40 grams, sodium bicarbonate 24 grams, Herba Epimedii 24 grams, Herba Plantaginis 24 grams, Herba Scutellariae Barbatae 40 grams, Herba Patriniae 40 grams, Herba Cistanches 24 grams is formulated.
Current clinical treatment leukemia, doctor trained in Western medicine mainly takes chemotherapy, and chemotherapy side effect is large, easily makes leukaemia develop immunity to drugs or drug resistance, and heavy dose also can not 100% ground total kill leukaemia again, so the root that residual leukaemia is always recurred.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide the leukemic Chinese medicine preparation of a kind of control and method for making.The present invention safely, have no side effect, without Drug resistance or drug resistance, regulate body immune level, impel body recovery immunologic function, the leukaemia in patient body can be killed completely, thus reach and prevent the leukemic object recurred once again.
Technical scheme of the present invention is:
The leukemic Chinese medicine preparation of a kind of control, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Pseudostellariae 7-12, Radix Et Caulis Acanthopanacis Senticosi 4-10, flame grass 9-13, Chinese fanpalm seed 6-12, Herba Andrographis 8-14, Rhizoma Menispermi 6-10, Caulis Spatholobi 8-13, Herba Patriniae 7-14, Herba Hedyotidis Diffusae 6-13, Herba Cyathulae Prostratae 5-11, Herba Cistanches 7-11, bright and beautiful Rhizoma et radix valerianae 5-12, Radix Angelicae Sinensis 6-11, Rhizoma Polygoni sinensis 3-8.
The leukemic Chinese medicine preparation of a kind of control, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Pseudostellariae 9-11, Radix Et Caulis Acanthopanacis Senticosi 6-8, flame grass 10-12, Chinese fanpalm seed 8-10, Herba Andrographis 11-13, Rhizoma Menispermi 7-9, Caulis Spatholobi 9-12, Herba Patriniae 9-12, Herba Hedyotidis Diffusae 10-12, Herba Cyathulae Prostratae 7-10, Herba Cistanches 8-10, brocade Rhizoma et radix valerianae 6-9, Radix Angelicae Sinensis 7-10, Rhizoma Polygoni sinensis 5-7.
The leukemic Chinese medicine preparation of a kind of control, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Pseudostellariae 10, Radix Et Caulis Acanthopanacis Senticosi 7, flame grass 11, Chinese fanpalm seed 9, Herba Andrographis 12, Rhizoma Menispermi 8, Caulis Spatholobi 11, Herba Patriniae 10, Herba Hedyotidis Diffusae 11, Herba Cyathulae Prostratae 9, Herba Cistanches 9, brocade Rhizoma et radix valerianae 7, Radix Angelicae Sinensis 8, Rhizoma Polygoni sinensis 6.
Present invention also offers the preparation method leukemic for aforementioned control Chinese medicine preparation being made pharmaceutically acceptable thick paste agent, powder, pill and granule.
The preparation method of described thick paste agent is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the clear paste (preferred slow fire is concentrated into the clear paste that relative density is 1.26) that relative density is 1.2-1.3, add step (3) gained, stir, add clear paste weight 1-1.5 Mel (preferably adding the Mel of clear paste weight 1.2 times) doubly, stir, boil 1-4 minute (preferably boiling 2 minutes), foam removal, seals in dress aseptic bottle, to obtain final product.
The preparation method of described powder is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste (preferred slow fire is concentrated into the thick paste that relative density is 1.34) that relative density is 1.32-1.35, vacuum drying, take out, be ground into fine powder, cross No. eight sieves, add the mixing of step (3) gained, with 5g/ bag sterile packaged, to obtain final product.
The preparation method of described pill is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. six sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste (preferred slow fire is concentrated into the thick paste that relative density is 1.34) that relative density is 1.32-1.35, vacuum drying, takes out, be ground into fine powder, cross No. six sieves, add the mixing of step (3) gained, with water pill, make the pill that particle diameter is 3mm, 50 DEG C of water content being dried to pill are lower than 2%, and subpackage, to obtain final product.
The preparation method of described granule is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. six sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the clear paste (preferred slow fire is concentrated into the clear paste that relative density is 1.15) that relative density is 1.12-1.18, add step (3) gained, stir, add soluble starch and maltodextrin, the weight of soluble starch is the 1-1.3 of gained weight after mixing doubly (weight of preferred soluble starch is 1.1 times of gained weight after mixing), the weight of maltodextrin is the weight of the preferred maltodextrin of 32%-45%(of gained weight after mixing is 38% of gained weight after mixing), first make that " hands is pinched agglomerating, namely flicking falls apart " soft material, uniform granule is made by 16 eye mesh screens again with fashion of extrusion, dry, granulate, subpackage, obtain.
The leukemic Chinese medicine preparation of control provided by the invention safely, have no side effect, determined curative effect.In addition, excellent results of the present invention also shows:
1, without Drug resistance or drug resistance;
2, there is heat-clearing and toxic substances removing, benefit strengthening spleen and lung, blood circulation promoting and blood stasis dispelling, replenishing kidney, strengthening waist, benefiting vital QI for tranquillizing, hard masses softening and resolving, dampness removing only
Blood, benefiting essence-blood, effect of invigorating blood circulation of enriching blood, regulate body immune level, impel body recovery immunologic function, can kill the leukaemia in patient body completely, thus reach and prevent the leukemic object recurred once again;
Scientific formula, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry;
3, medical expense is lower, and patient is easy to accept;
5, take natural Chinese medicinal herb as primary raw material, medicine source is easy to get and cheap.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the leukemic Chinese medicine preparation of a kind of control, the primary raw material medicine getting following weight parts is prepared from (every part is 240g): Radix Pseudostellariae 7 parts, Radix Et Caulis Acanthopanacis Senticosi 4 parts, flame grass 9 parts, Chinese fanpalm seed 6 parts, Herba Andrographis 8 parts, Rhizoma Menispermi 6 parts, Caulis Spatholobi 8 parts, Herba Patriniae 7 parts, Herba Hedyotidis Diffusae 6 parts, Herba Cyathulae Prostratae 5 parts, Herba Cistanches 7 parts, bright and beautiful Rhizoma et radix valerianae 5 parts, Radix Angelicae Sinensis 6 parts, Rhizoma Polygoni sinensis 3 parts.
The preparation method of the leukemic Chinese medicine preparation powder of above-mentioned control is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot and makes popular, add mixed four kinds of Chinese crude drugs and stir with fluvial sand, stir-fry in 125 DEG C, fry 11 minutes, take out, sieve removes fluvial sand, cools, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28g, puts in tank airtight, sits in kettle, and it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40 DEG C of baking ovens, dry 7.5 hours, takes out, be ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5 times of water gagings, decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, join step (4) and fill in the pot of medicinal residues, decoct with water twice, add the water of 13 taste Chinese crude drug 8 times at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste that relative density is 1.32, vacuum drying, takes out, is ground into fine powder, crosses No. eight sieves, adds the mixing of step (3) gained, with 5g/ bag sterile packaged, to obtain final product.
The instructions of taking that gained of the present invention prevents and treats leukemic Chinese medicine preparation powder is: oral, one day twice, and each 5g, boiled water is taken after mixing it with water.
embodiment 2the leukemic Chinese medicine preparation of a kind of control, the primary raw material medicine getting following weight parts is prepared from (every part is 240g): Radix Pseudostellariae 12 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, flame grass 13 parts, Chinese fanpalm seed 12 parts, Herba Andrographis 14 parts, Rhizoma Menispermi 10 parts, Caulis Spatholobi 13 parts, Herba Patriniae 14 parts, Herba Hedyotidis Diffusae 13 parts, Herba Cyathulae Prostratae 11 parts, Herba Cistanches 11 parts, bright and beautiful Rhizoma et radix valerianae 12 parts, Radix Angelicae Sinensis 11 parts, Rhizoma Polygoni sinensis 8 parts.
The preparation method of above-mentioned control leukemic Chinese medicine preparation thick paste agent is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot and makes popular, add mixed four kinds of Chinese crude drugs and stir with fluvial sand, stir-fry in 135 DEG C, fry 14 minutes, take out, sieve removes fluvial sand, cools, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 38g, puts in tank airtight, sits in kettle, and it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 50 DEG C of baking ovens, dry 9.5 hours, takes out, be ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 7.4 times of water gagings, decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, join step (4) and fill in the pot of medicinal residues, decoct with water twice, add the water of 13 taste Chinese crude drug 9 times at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the clear paste that relative density is 1.26, adds step (3) gained, stirs, add the Mel of clear paste weight 1.2 times, stir, boil 2 minutes, foam removal, seals in dress aseptic bottle, to obtain final product.
model case one:model XX, man, 46 years old.Before more than 2 years, there is dizziness, weak in patient, and companion's gingival hemorrhage symptom, through examination in hospital, is diagnosed as leukemia.Give the chemotherapy of related drugs, the state of an illness again and again.Introduce by friend, carry out here diagnosis and treatment.Have a blood test leukocyte 75 × l0 9/ L, platelet 60 × l0 9/ L.Leukemia is diagnosed as after bone marrow cytomorphologic examination.Take the present embodiment gained and prevent and treat the agent of leukemic Chinese medicine preparation thick paste, three times on the one, each 12g, boiled water is taken after mixing it with water.After taking 2 months, symptom is clearly better, and hemogram recovers normal.Continue to take 2 months, reach complete incidence graph.Follow up a case by regular visits to without rebound phenomenon.
embodiment 3the leukemic Chinese medicine preparation of a kind of control, the primary raw material medicine getting following weight parts is prepared from (every part is 240g): Radix Pseudostellariae 9 parts, Radix Et Caulis Acanthopanacis Senticosi 6 parts, flame grass 10 parts, Chinese fanpalm seed 8 parts, Herba Andrographis 11 parts, Rhizoma Menispermi 7 parts, Caulis Spatholobi 9 parts, Herba Patriniae 9 parts, Herba Hedyotidis Diffusae 10 parts, Herba Cyathulae Prostratae 7 parts, Herba Cistanches 8 parts, bright and beautiful Rhizoma et radix valerianae 6 parts, Radix Angelicae Sinensis 7 parts, Rhizoma Polygoni sinensis 5 parts.
The preparation method of the leukemic Chinese medicine preparation pill of above-mentioned control is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot and makes popular, add mixed four kinds of Chinese crude drugs and stir with fluvial sand, stir-fry in 135 DEG C, fry 14 minutes, take out, sieve removes fluvial sand, cools, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 38g, puts in tank airtight, sits in kettle, and it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 50 DEG C of baking ovens, dry 9.5 hours, takes out, be ground into fine powder, cross No. six sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 7.4 times of water gagings, decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, join step (4) and fill in the pot of medicinal residues, decoct with water twice, add the water of 13 taste Chinese crude drug 9 times at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste that relative density is 1.34, vacuum drying, takes out, be ground into fine powder, cross No. six sieves, add the mixing of step (3) gained, with water pill, make the pill that particle diameter is 3mm, 50 DEG C of water content being dried to pill are lower than 2%, and subpackage, to obtain final product.
model case two:wei, XX, male, 53 years old.Before more than 1 year, having a dizzy spell appears in patient, greyish white with complexion.Go to a doctor at local hospital, find that blood leukocytes increases, be finally diagnosed as leukemia.Chemotherapy repeatedly, has no positive effect.Upon somebody's introduction, here diagnosis and treatment are carried out.Patient has a dizzy spell, and complexion is greyish white, fatigue and weak, and skin has ecchymosis, hepatosplenomegaly, and pale tongue is fat, thin white fur of tongue, and stringy pulse sinks.Routine blood test: WBC:91.8 × l0 9/ L, Hb:113g/L, PLT:80 × l0 9/ L.Wear inspection through bone again, be diagnosed as leukemia.Take the present embodiment gained and prevent and treat leukemic Chinese medicine preparation pill, three times on the one, each 6 balls, warm water takes.After taking 1 month, the state of an illness is clearly better.Continue to take 2 months, reach complete incidence graph state.Follow up a case by regular visits to without rebound phenomenon.
embodiment 4the leukemic Chinese medicine preparation of a kind of control, the primary raw material medicine getting following weight parts is prepared from (every part is 240g): Radix Pseudostellariae 11 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, flame grass 12 parts, Chinese fanpalm seed 10 parts, Herba Andrographis 13 parts, Rhizoma Menispermi 9 parts, Caulis Spatholobi 12 parts, Herba Patriniae 12 parts, Herba Hedyotidis Diffusae 12 parts, Herba Cyathulae Prostratae 10 parts, Herba Cistanches 10 parts, bright and beautiful Rhizoma et radix valerianae 9 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Polygoni sinensis 7 parts.
The preparation method of the leukemic Chinese medicine preparation granule of above-mentioned control is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot and makes popular, add mixed four kinds of Chinese crude drugs and stir with fluvial sand, stir-fry in 135 DEG C, fry 14 minutes, take out, sieve removes fluvial sand, cools, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 38g, puts in tank airtight, sits in kettle, and it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 50 DEG C of baking ovens, dry 9.5 hours, takes out, be ground into fine powder, cross No. six sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 7.4 times of water gagings, decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, join step (4) and fill in the pot of medicinal residues, decoct with water twice, add the water of 13 taste Chinese crude drug 9 times at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the clear paste that relative density is 1.15, adds step (3) gained, stir, add soluble starch and maltodextrin, the weight of soluble starch is 1.1 times of gained weight after mixing, and the weight of maltodextrin is 38% of gained weight after mixing, first make the soft material of " hands is pinched agglomerating, flicking and namely fallen apart ", uniform granule is made by 16 eye mesh screens again with fashion of extrusion, dry, granulate, subpackage, to obtain final product.
model case three:yuan XX, female, 28 years old.Before more than 3 years, there is pale complexion in patient, fatigue and weak symptom.Through local hospital inspection, examine as leukemia.Through repeatedly chemotherapy, the state of an illness fails to control, and occurs serious side effect.By making some inquiries about, here diagnosis and treatment of coming.Take the present embodiment gained and prevent and treat leukemic Chinese medicine preparation granule, three times on the one, each 15g, boiled water is taken after mixing it with water.After taking 3 months, the state of an illness is clearly better.After taking half a year, every laboratory indexes is all tending towards normal.Follow up a case by regular visits to without rebound phenomenon.
embodiment 5the leukemic Chinese medicine preparation of a kind of control, the primary raw material medicine getting following weight parts is prepared from (every part is 240g): Radix Pseudostellariae 10 parts, Radix Et Caulis Acanthopanacis Senticosi 7 parts, flame grass 11 parts, Chinese fanpalm seed 9 parts, Herba Andrographis 12 parts, Rhizoma Menispermi 8 parts, Caulis Spatholobi 11 parts, Herba Patriniae 10 parts, Herba Hedyotidis Diffusae 11 parts, Herba Cyathulae Prostratae 9 parts, Herba Cistanches 9 parts, bright and beautiful Rhizoma et radix valerianae 7 parts, Radix Angelicae Sinensis 8 parts, Rhizoma Polygoni sinensis 6 parts.
The preparation method of the leukemic Chinese medicine preparation powder of above-mentioned control is:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot and makes popular, add mixed four kinds of Chinese crude drugs and stir with fluvial sand, stir-fry in 135 DEG C, fry 14 minutes, take out, sieve removes fluvial sand, cools, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 38g, puts in tank airtight, sits in kettle, and it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 50 DEG C of baking ovens, dry 9.5 hours, takes out, be ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 7.4 times of water gagings, decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, join step (4) and fill in the pot of medicinal residues, decoct with water twice, add the water of 13 taste Chinese crude drug 9 times at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste that relative density is 1.34, vacuum drying, takes out, is ground into fine powder, crosses No. eight sieves, adds the mixing of step (3) gained, with 5g/ bag sterile packaged, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Pseudostellariae: base is former: be the tuber of pinkwort Radix Ginseng.The property of medicine: sweet, micro-hardship, cold nature.Return spleen, lung meridian.Function cures mainly: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Main weakness of the spleen and stomach, inappetence, lassitude, impairment of both QI and YIN, dry cough expectorant is few, and spontaneous perspiration is breathed hard, and the convalescent stage of febrile disease deficiency of vital energy Tianjin wound, and interior-heat is thirsty, or neurasthenia, palpitation and insomnia, dizzy forgetful, Infantile Summer Fever.
Radix Et Caulis Acanthopanacis Senticosi: base is former: be the root of Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf.The property of medicine: mildly bitter flavor; Pungent; Warm in nature.Return spleen; Kidney; Heart channel.Function cures mainly: replenishing kidney, strengthening waist; Benefiting vital QI for tranquillizing; Promoting blood circulation to remove obstruction in the collateral.Main kidney deficiency and bodily weakness; Soreness of the waist and knees; Children's's walking retardation in children; Insufficiency of the spleen weak; Deficiency of vital energy edema; Inappetence; Insomnia and dreamful sleep; Forgetful; Thoracic obstruction pain; Anemofrigid-damp arthralgia; Treating swelling and pain by traumatic injury.
Flame grass: base is former: be the herb of crassulaceae plants flame grass.The property of medicine: micro-hardship; Cool.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main pathopyretic ulcer; Acute mastitis; Erysipelas; Innominate toxic swelling; Burn due to hot liquid or fire; Laryngopharynx swelling and pain; Gingivitis; Heat in blood is spitted blood; Spitting of blood; Epistaxis; Traumatic hemorrhage.
Chinese fanpalm seed: another name seed of Livistona chinensis R.Br..Base is former: be the seed of babassu Semen livistonae chinensis.Chemical analysis: seed contains phenols, reducing sugar, tannin, triacylglycerol, aminoacid: lysine, serine, arginine, proline, tyrosine, valine, isoleucine, phenylalanine, sugar, vitamin C and ascorbic acid.The oil of shell and kernel is mainly containing oleic acid.The property of medicine: sweet, bitter, flat, mild toxicity.Function cures mainly: blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Guangzhou army " conventional Chinese herbal medicine handbook ": " seed of Livistona chinensis R.Br. is anticancer." main chronic hepatitis, lump in the abdomen.
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.The property of medicine: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." " Quanzhou book on Chinese herbal medicine ": " enter the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Rhizoma Menispermi: base is former: be the rhizome of menispermaceae plant Caulis menispermi.The property of medicine: bitter; Cold; Slightly poisonous.Return lung, stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing; Reducing swelling and alleviating pain; Dampness removing.Main laryngopharynx swelling and pain; Cough due to lung-heat; Mumps; Dysentery; Jaundice; Rheumatic arthralgia; Swelling and pain of hemorrhoid; Snake bite and insect sting.
Caulis Spatholobi: base is former: be the rattan of leguminous plant spatholobus suberectus, Mucuna birdwoodiana, fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan or bright leaf Moghania fluminalis(C. B. Clarke) Li rattan etc.Chemical analysis: fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan is containing milletol.The property of medicine: bitter sweet, temperature." book on Chinese herbal medicine is new again ": " enter the heart, spleen two warp." function cures mainly: to invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.
Herba Patriniae: base is former: be the herb of Valerianaceae plant Patrinia scabiosaefolia Fisch and patrima villosa.The property of medicine: acrid in the mouth; Bitter; Cold nature.Function cures mainly: heat-clearing and toxic substances removing; To invigorate blood circulation evacuation of pus.Main intestinal carbuncle; Lung abscess; Carbuncle; Dysentery; The stagnant stomachache of the stasis of blood in puerperal.
Herba Hedyotidis Diffusae: base is former: be the whole herb with root of Radix Rubiae kind of plant Herba Hedyotidis Diffusae.Chemical analysis: separate 1 alkane, stigmasterol, ursolic acid, oleanolic acid in herb, cupreol, cupreol-D-Glucose glycoside, P-coumaric acid etc.The property of medicine: bitter, sweet, cold." Guangxi Chinese medicinal herbal ": " entering the heart, liver, spleen three warp ".Function cures mainly: heat clearing away, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Pharyngolaryngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom, tumor.Also can be used for alimentary tract cancer.
Herba Cyathulae Prostratae: base is former: be the aerial parts of amaranthaceous plant Herba Cyathulae Prostratae.The property of medicine: bitter, cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation to remove blood stasis.Main carbuncle pyogenic infections from tumour or sore; Venom; Traumatic injury congestive edema.
Herba Cistanches: base is former: be the fleshy stem of orobanchaceae plant cistanche.The property of medicine: sweet in the mouth; Salty; Warm in nature.Return kidney, large intestine channel.Function cures mainly: kidney-replenishing, benefiting essence-blood, intestine moistening road.Main kidney yang deficiency, the sexual impotence of asthenia of essence and blood, seminal emission, nebulousurine, the frequent micturition heeltap, lumbago flaccidity of the lower limbs, tinnitus order flower, menstruation is spread out the phase, infertility, dryness of the intestine constipation.
Brocade Rhizoma et radix valerianae: base is former: be herb or the root of Melastomateae plants brocade Rhizoma et radix valerianae.The property of medicine: bitter in the mouth; Pungent; Cold in nature.Function cures mainly: clearing away heat and cooling blood; Dampness removing.Main toxic-heat and blood stasis; Damp-heat vaginal discharge; Menoxenia; Metrorrhagia due to blood-heat; The hot hemorrhoidal bleeding of intestinal; The enlargement of children's's scrotum.
Radix Angelicae Sinensis: base is former: this product is the dry root of umbelliferae angelica.The property of medicine: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores.
Rhizoma Polygoni sinensis: base is former: for the rhizome of stem knotweed is embraced by polygonaceae plant China.The property of medicine: acid; Bitter; Property is put down; Poisonous.Function cures mainly: heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation; Promoting the circulation of QI to relieve pain; Hemostasia and promoting granulation.Main cold, fever; Laryngopharynx swelling and pain; Have loose bowels; Dysentery; Traumatic injury; Gastric abscess; Dysmenorrhea; Metrorrhagia; Traumatic hemorrhage.
test example 1gained of the present invention prevents and treats the clinical practice of leukemic Chinese medicine preparation (embodiment 5): in February ,-2009 in February, 2007, screens 180 routine leukaemics carry out clinical observation in 5 hospitals.Wherein male 95 example, women 85 example, 15 years old ~ 68 years old age.All cases are all taken gained of the present invention and are prevented and treated leukemic Chinese medicine preparation, instructions of taking: oral, one day twice, and each 5g, boiled water is taken after mixing it with water.
The standard of curative effect evaluation: complete incidence graph: (1) bone marrow smear: single or former pouring+young lymphocyte number≤5% of myeloblast (I type+II type) or former list+children, erythrocyte and megakaryocytic series normal.Wherein M2b neutrophilic myelocyte ratio is in normal range; In M3 type original grain+morning young grain≤5%; M4 type Central Plains grain I type+II type+former list+children's list≤5%; M6 type Central Plains grain I type+II type≤5%, former red+children's red and red system ratio is normal; In M7, grain, red two is that ratio is normal, former huge and young huge basic disappearance.(2) hemogram: hemoglobin (Hb)>=100g/L(man) or>=90g/L(women and child), neutrophilic granulocyte absolute value>=1.5 × l0 9/ L, platelet count>=100 × l0 9/ L, point apoplexy due to endogenous wind is without leukaemia.(3) clinical manifestation: without the sings and symptoms caused by leukemic infiltration, life is normal or close normal.Partial rcsponse: myeloblast I type+II type in bone marrow (or former list+children is single or former pouring+children pouring) > 5% ,≤20%, or have one not reach complete incidence graph standard person in clinical, hemogram two.Do not alleviate: bone marrow smear, hemogram and clinical three all do not reach above-mentioned standard person.Result is as shown in table 1.
Table 1: gained of the present invention prevents and treats leukemic Chinese medicine preparation compliance test result
As can be seen from Table 1, take medicine in 2 months, complete incidence graph 58 example, partial rcsponse 94 example, do not alleviate 28 examples; Take medicine in 4 months, complete incidence graph 105 example, partial rcsponse 63 example, do not alleviate 12 examples; Take medicine in 6 months, complete incidence graph 176 example, partial rcsponse 3 example, do not alleviate 1 example.As shown in Table 1, gained of the present invention prevents and treats leukemic Chinese medicine preparation Be very effective, determined curative effect.
The present invention, through scientific compatibility, with pure natural Chinese herbal medicine such as Radix Pseudostellariae, Radix Et Caulis Acanthopanacis Senticosi, flame grass and Chinese fanpalm seeds for primary raw material, makes the leukemic Chinese medicine preparation of control.In side, Radix Pseudostellariae mends strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Radix Et Caulis Acanthopanacis Senticosi replenishing kidney, strengthening waist; Benefiting vital QI for tranquillizing; Promoting blood circulation to remove obstruction in the collateral.Flame grass heat-clearing and toxic substances removing; Cooling blood for hemostasis.Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Rhizoma Menispermi heat-clearing and toxic substances removing; Reducing swelling and alleviating pain; Dampness removing.Caulis Spatholobi is invigorated blood circulation, relaxing muscles and tendons.Herba Patriniae heat-clearing and toxic substances removing; To invigorate blood circulation evacuation of pus.Herba Hedyotidis Diffusae heat clearing away, dampness removing, removing toxic substances.Herba Cyathulae Prostratae heat-clearing and toxic substances removing; Promoting blood circulation to remove blood stasis.Herba Cistanches kidney-replenishing, benefiting essence-blood, intestine moistening road.Brocade Rhizoma et radix valerianae clearing away heat and cooling blood; Dampness removing.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Rhizoma Polygoni sinensis heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation; Promoting the circulation of QI to relieve pain; Hemostasia and promoting granulation.Many medicines share, phase and coordination, play heat-clearing and toxic substances removing altogether, mend strengthening spleen and lung, blood circulation promoting and blood stasis dispelling, replenishing kidney, strengthening waist, benefiting vital QI for tranquillizing, hard masses softening and resolving, dampness removing hemostasis, benefiting essence-blood, the effect of invigorating blood circulation of enriching blood, regulate body immune level, impel body recovery immunologic function, the leukaemia in patient body can be killed completely, thus reach and prevent the leukemic object recurred once again.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. prevent and treat a leukemic Chinese medicine preparation, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Pseudostellariae 7-12, Radix Et Caulis Acanthopanacis Senticosi 4-10, flame grass 9-13, Chinese fanpalm seed 6-12, Herba Andrographis 8-14, Rhizoma Menispermi 6-10, Caulis Spatholobi 8-13, Herba Patriniae 7-14, Herba Hedyotidis Diffusae 6-13, Herba Cyathulae Prostratae 5-11, Herba Cistanches 7-11, brocade Rhizoma et radix valerianae 5-12, Radix Angelicae Sinensis 6-11, Rhizoma Polygoni sinensis 3-8.
2. the leukemic Chinese medicine preparation of control as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Pseudostellariae 9-11, Radix Et Caulis Acanthopanacis Senticosi 6-8, flame grass 10-12, Chinese fanpalm seed 8-10, Herba Andrographis 11-13, Rhizoma Menispermi 7-9, Caulis Spatholobi 9-12, Herba Patriniae 9-12, Herba Hedyotidis Diffusae 10-12, Herba Cyathulae Prostratae 7-10, Herba Cistanches 8-10, brocade Rhizoma et radix valerianae 6-9, Radix Angelicae Sinensis 7-10, Rhizoma Polygoni sinensis 5-7.
3. the leukemic Chinese medicine preparation of control as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Pseudostellariae 10, Radix Et Caulis Acanthopanacis Senticosi 7, flame grass 11, Chinese fanpalm seed 9, Herba Andrographis 12, Rhizoma Menispermi 8, Caulis Spatholobi 11, Herba Patriniae 10, Herba Hedyotidis Diffusae 11, Herba Cyathulae Prostratae 9, Herba Cistanches 9, brocade Rhizoma et radix valerianae 7, Radix Angelicae Sinensis 8, Rhizoma Polygoni sinensis 6.
4. the preparation method of the thick paste agent of the leukemic Chinese medicine preparation of control as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the clear paste (preferred slow fire is concentrated into the clear paste that relative density is 1.26) that relative density is 1.2-1.3, add step (3) gained, stir, add clear paste weight 1-1.5 Mel (preferably adding the Mel of clear paste weight 1.2 times) doubly, stir, boil 1-4 minute (preferably boiling 2 minutes), foam removal, seals in dress aseptic bottle, to obtain final product.
5. the preparation method of the powder of the leukemic Chinese medicine preparation of control as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot and makes popular, add mixed four kinds of Chinese crude drugs and stir with fluvial sand, stir-fry in 125-150 DEG C, fry 11-16 minute, take out, sieve removes fluvial sand, cools, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g, puts in tank airtight, sits in kettle, and it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. eight sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste (preferred slow fire is concentrated into the thick paste that relative density is 1.34) that relative density is 1.32-1.35, vacuum drying, take out, be ground into fine powder, cross No. eight sieves, add the mixing of step (3) gained, with 5g/ bag sterile packaged, to obtain final product.
6. the preparation method of the pill of the leukemic Chinese medicine preparation of control as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. six sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the thick paste (preferred slow fire is concentrated into the thick paste that relative density is 1.34) that relative density is 1.32-1.35, vacuum drying, takes out, be ground into fine powder, cross No. six sieves, add the mixing of step (3) gained, with water pill, make the pill that particle diameter is 3mm, 50 DEG C of water content being dried to pill are lower than 2%, and subpackage, to obtain final product.
7. the preparation method of the granule of the leukemic Chinese medicine preparation of control as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) by Radix Pseudostellariae, Rhizoma Menispermi, Radix Angelicae Sinensis and Rhizoma Polygoni sinensis mixing, fluvial sand is put into pot make popular, add mixed four kinds of Chinese crude drugs to stir with fluvial sand, in 125-150 DEG C stir-fry (being preferable over 135 DEG C to stir-fry), fry 11-16 minute (preferably frying 14 minutes), take out, sieve removes fluvial sand, cool, for subsequent use;
(2) get Chinese fanpalm seed, mix thoroughly with yellow wine, every 100g Chinese fanpalm seed yellow wine 28-45g(is every 100g Chinese fanpalm seed yellow wine 38g preferably), put in tank airtight, sit in kettle, it is degree to the greatest extent that water proof heating is steamed to wine, takes out, dries;
(3) Herba Cistanches is placed in 40-55 DEG C of baking oven (being preferably placed in 50 DEG C of baking ovens), dry 7.5-11 hour (preferably dry 9.5 hours), take out, are ground into fine powder, cross No. six sieves;
(4) by Radix Et Caulis Acanthopanacis Senticosi, flame grass, Herba Andrographis, Caulis Spatholobi, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Cyathulae Prostratae and the mixing of bright and beautiful Rhizoma et radix valerianae, add 6.5-8 times of water gaging (preferably adding 7.4 times of water gagings), decoct 1 hour, leach medicinal liquid;
(5) by step (1) and the mixing of step (2) gained, joining step (4) fills in the pot of medicinal residues, decocts with water twice, adds 13 taste Chinese crude drug 8-10 water (preferably at every turn adding the water of 13 taste Chinese crude drug 9 times) doubly at every turn, each decoction 1.2 hours, merges twice medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, slow fire is concentrated into the clear paste (preferred slow fire is concentrated into the clear paste that relative density is 1.15) that relative density is 1.12-1.18, add step (3) gained, stir, add soluble starch and maltodextrin, the weight of soluble starch is the 1-1.3 of gained weight after mixing doubly (weight of preferred soluble starch is 1.1 times of gained weight after mixing), the weight of maltodextrin is the weight of the preferred maltodextrin of 32%-45%(of gained weight after mixing is 38% of gained weight after mixing), first make that " hands is pinched agglomerating, namely flicking falls apart " soft material, uniform granule is made by 16 eye mesh screens again with fashion of extrusion, dry, granulate, subpackage, obtain.
8. the preparation method of the powder of the leukemic Chinese medicine preparation of control as claimed in claim 5, it is characterized in that, step stir-fries in 135 DEG C in (1).
9. the preparation method of the powder of the leukemic Chinese medicine preparation of control as claimed in claim 5, is characterized in that, fries 14 minutes in step (1).
10. the preparation method of the powder of the leukemic Chinese medicine preparation of control as claimed in claim 5, is characterized in that, every 100g Chinese fanpalm seed yellow wine 38g in step (2).
CN201510866495.0A 2015-12-02 2015-12-02 Traditional Chinese medicine preparation for preventing and treating leukemia and preparing method thereof Pending CN105362556A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075387A (en) * 2016-06-26 2016-11-09 张伟强 A kind of oral formulations treating chronic leukemia and preparation method thereof
WO2022079090A1 (en) * 2020-10-13 2022-04-21 Tilman Sa Composition comprising at least one labdane diterpene and method for manufacturing same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103127295A (en) * 2013-03-01 2013-06-05 郭华 Traditional Chinese medicine formula for treating leukemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103127295A (en) * 2013-03-01 2013-06-05 郭华 Traditional Chinese medicine formula for treating leukemia

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075387A (en) * 2016-06-26 2016-11-09 张伟强 A kind of oral formulations treating chronic leukemia and preparation method thereof
WO2022079090A1 (en) * 2020-10-13 2022-04-21 Tilman Sa Composition comprising at least one labdane diterpene and method for manufacturing same
BE1028699B1 (en) * 2020-10-13 2022-05-16 Eleonor Composition comprising at least one labdanum diterpene and process for its manufacture

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