CN105012734A

CN105012734A - Chinese herbal preparation for treating lymphatic leukemia and preparation method of Chinese herbal preparation

Info

Publication number: CN105012734A
Application number: CN201510433302.2A
Authority: CN
Inventors: 鄢明亮; 周培林
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-22
Filing date: 2015-07-22
Publication date: 2015-11-04

Abstract

The invention discloses a Chinese herbal preparation for treating lymphatic leukemia and a preparation method of the Chinese herbal preparation. The Chinese herbal preparation is prepared from the following Chinese traditional medicines by weight: 15-20g of antelope's horn, 20-30g of oldenlandia diffusa, 20-30g of sculellaria barbata, 20-30g of cremastra appendiculata, 10-15g of radix scrophulariae, 20-30g of lithospermum, 20-30g of nacre mother of pearl, 3-5g of cinnabar, 20-30g of trimeresurus stejnegeri, 10-15g of ground beeltle, 10-15g of indigo naturalis, 5-10g of pseudo-ginseng, 20-30g of lalang grass rhizome, 10-15g of rhizoma bletillae, 15-20g of rhizoma acori graminei, 12-18g of rhinoceros horn, and 40-60g of buffalo horn. The Chinese herbal preparation for treating lymphatic leukemia has the efficacies of rapidly killing leukemia cell, inhibiting and eliminating related cancer cells and tumour cells, softening hard mass and freeing gate, promoting blood circulation to remove blood stasis, removing toxicity for detumescence, improving the hematopoietic function, and boosting the immunity, has rapid improving and treating effects for clinical symptoms related to leukemia, and has an extraordinary treatment effect for Leukemia patients who are difficult to treat.

Description

A kind of Chinese medicine preparation and preparation method for the treatment of main lymphoid leukemia

Technical field

The present invention relates to a kind of Chinese medicine preparation, especially provide a kind of Chinese medicine preparation and preparation method for the treatment of main lymphoid leukemia.

Background technology

Lymphocytic leukemia (chronic lymphocytic leukemia, CLL) is a kind of lymphocyteclonal expansion tumorproperty disease, lymphocyte exists bone marrow, lymph node, blood, spleen, liverand other organs are assembled.The CLL of more than 95% is b cellclonal expansion (i.e. B-CLL), less than the case of 5% be only t cellphenotype (i.e. T-CLL).Paraplasm germinal cell can be assembled at bone marrow and suppress normal hematopoiesis function, also can invade and extraperiosteal tissue, as meninges, lymph node, gonad, liver etc. simultaneously.China once carried out the investigation of leukemia incidence, and ALL sickness rate is about 0.67/10 ten thousand.In oil field, contaminated area sickness rate is apparently higher than national sickness rate.The childhood period of ALL, (0 ~ 9 years old) is onset peak, can account for more than 70% of leukemia of children.ALL accounts for about 20% of adult leukemia in adult.The current biological characteristics different according to ALL is formulated corresponding therapeutic scheme and is obtained good therapeutic effect, and the child of about 80% and the adult of 30% can obtain long-term disease-free survival, and have the possibility of healing.

Lymphocytic leukemia is the same with other leukemia, and the generation of leukaemia and development origin are hemopoietic progenitor cell or stem cell.At present, for its cause of disease and pathogenesis not yet completely clear, but relevant with some risk factors.

1. heredity and familial factor

About 5%ALL is relevant to inherited genetic factors.The syndromic Patient leukemic's sickness rate of genetic predisposition is more particularly had to increase.

2. environmental effect

Ionizing radiation is affirmed as one of human leukemia inducement, but mechanism is not bright, the crowd ALL morbidity showed increased especially after suffering radioprotective.Chemical substance such as benzene and benzene congener, alkylating agent are considered to closely related with human leukemia.

3. gene alteration

All ALL cells have acquired gene alteration, the change such as comprise chromosome number and structure transposition, inversion, disappearance, point mutation and repeat.

The leukemic many medicines of current treatment and method, effect is all more single, and has certain or suitable toxic and side effects.Adverse effect and catastrophic collapse are brought to patient's normal organ or function.Many patients have controlled this disease produce again that disease vicious cycle experience, some patients even this disease do not control, that disease produces again, how distressed these are the nightmares making people, main flow Therapeutic Method gets more and more, common are electrotherapy, chemotherapy, X-ray therapy, the qigong, psychotherapy, Chinese and Western medication, the method for operation etc. many treatments " leukemia ".Wherein " bone marrow transplantation " has broken the deified invention of " leukemia " uncurable disease.But Gonna breakthrough deifies thing that neither be so easy, " bone marrow " pairing is a difficult problem, 100,000/; Expense be difficult problem 200,000 yuan to 500,000 yuan not etc.There are how many patients can bear these difficult problems.Some health body constitution is poor, advanced age leukaemic find " bone marrow " suitable pairings not also to be applicable to performing an operation, therefore provide pure Chinese medicine formula specially to control lymphoid leukemia, therapeutic effect significantly meets clinical practice and popularization.

Summary of the invention

The object of the present invention is to provide to have and kill leukaemia fast, can limit and remove relevant cancerous cell and tumor cell, the clearance of energy softening the hard mass, blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling, improves hemopoietic function, enhancing immunity; Have leukemic pertinent clinical symptom and improve faster and a kind of Chinese medicine preparation of therapeutical effect, especially provide a kind of treat main lymphoid leukemia Chinese medicine preparation and the problem that proposes to meet above-mentioned background technology of preparation method.

To achieve these goals, the invention provides following technical scheme:

The Chinese medicine preparation of the main lymphoid leukemia for the treatment of of the present invention, it is mixed with by the raw material of Chinese medicine of following weight proportioning: Cornu Saigae Tataricae 15 ~ 20g, Herba Hedyotidis Diffusae 20 ~ 30g, Herba Scutellariae Barbatae 20 ~ 30g, Pseudobulbus Cremastrae Seu Pleiones 20 ~ 30g, Radix Scrophulariae 10 ~ 15g, Radix Arnebiae (Radix Lithospermi) 20 ~ 30g, Concha Margaritifera 20 ~ 30g, Cinnabaris 3 ~ 5g, Trimeresurus stejnegeri 20 ~ 30g, Eupolyphaga Seu Steleophaga 10 ~ 15g, Indigo Naturalis 10 ~ 15g, Radix Notoginseng 5 ~ 10g, Rhizoma Imperatae 20 ~ 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15g, Rhizoma Acori Graminei 15 ~ 20g, Cornu rhinocerotis 12 ~ 18g, Cornu Bubali 40 ~ 60g.

As the further scheme of the present invention: preferred to be mixed with by the raw material of Chinese medicine of following weight proportioning: Cornu Saigae Tataricae 18g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Pseudobulbus Cremastrae Seu Pleiones 30g, Radix Scrophulariae 15g, Radix Arnebiae (Radix Lithospermi) 30g, Concha Margaritifera 30g, Cinnabaris 5g, Trimeresurus stejnegeri 30g, Eupolyphaga Seu Steleophaga 15g, Indigo Naturalis 15g, Radix Notoginseng 10g, Rhizoma Imperatae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Acori Graminei 20g, Cornu rhinocerotis 15g, Cornu Bubali 50g.

Medical material used in the present invention has following characteristic:

Cornu Saigae Tataricae: [another name] saiga tatarica, [source] this product is the angle of bovid sahilite Saiga tatarica Linnaeus.[nature and flavor] are salty, cold.[return through] returns liver, heart channel.[function cures mainly] suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, loose blood removing toxic substances.For the hot infantile convulsion of height, coma convulsion is fainted, and eclamposia is twitched, and epilepsy is gone mad, and has a headache dizzy, cataract, maculae caused by violent heat pathogen, carbuncle sore tumefacting virus.

Herba Hedyotidis Diffusae: [another name] Herba Hedyotidis Diffusae, tang Huang, Serpentis needle grass, Radix Picriae felterrae, two leaf humulus, spend in vain cross grass, sharp knife grass, JIAMENGCAO, Herba Otteliae Alismoidis, Serpentis Lei grass, crane SHECAO, [source] this product is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].[nature and flavor] are sweet, light, cool.[return through] enters stomach, large intestine, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.

Herba Scutellariae Barbatae: [another name] careless, the narrow leaf Herba Scutellariae indicae of head, toothbrush are careless, Herba Scutellariae Darbatae, [source] this product is the dry herb of labiate Herba Scutellariae Barbatae Scutellaria barbata Don [S. rivularis Wall].[nature and flavor] are pungent, bitter, cold.[return through] returns lung, liver, kidney channel.[function cures mainly] heat-clearing and toxic substances removing, blood stasis dispelling diuresis.

Pseudobulbus Cremastrae Seu Pleiones: be the dry pseudobulb of orchid Cremastra appendiculata, pleione bulbocodioides or Pleione yunnanensis.The former practises title " hair Rhizoma sagittariae sagittifoliae ", and the latter two are practised and claim " pleionebulbocodioides rolfe ", and another name also has golden lamp, aunt Zhu, Herba pyrolae japonicae, nonsense grass etc.Summer, Qiu Erji excavate.Pseudobulbus Cremastrae Seu Pleiones sweet in the mouth, micro-pungent, cool in nature.Have heat-clearing and toxic substances removing, the effects such as eliminating carbuncle eliminating stagnation, are usually used in carbuncle furunculosis, scrofula sucutaneous nodule, snake bite and insect sting, lame abdominal mass mass in the abdomen.

Radix Scrophulariae: [another name] Radix Scrophulariae, black Radix Scrophulariae, black ginseng, [source] this product is goatweed radix Scrophulariaethe dry root of Scrophularia ningpoensis Hemsl..[nature and flavor] are sweet, bitter, salty, are slightly cold.[return through] returns lung, stomach, kidney channel.

[function cures mainly] removing heat from blood yIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.

Radix Arnebiae (Radix Lithospermi): [another name] gromwell root, Radix Arnebiae, [source] this product is the dry root of comfrey lithospermum euchromum Royle Arnebia euchroma (Royle) Johnst., Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb. et Zucc. or arnebia guttata Bunge Arnebia guttata Bunge.[nature and flavor] are sweet, salty, cold.[return through] GUIXIN, Liver Channel.

[function cures mainly] removing heat from blood, invigorates blood circulation, removing toxic substances rash.

Concha Margaritifera: [another name] natural pearls are female, jewel is female, [source] this product is the shell of Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea), cristaria plicata Cristaria plicata (Leach) or Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker).[nature and flavor] are salty, cold.[return through] returns liver, heart channel.[function cures mainly] suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.

Cinnabaris: [another name] cinnabar, cinnabar, [source] this product is sulfide-based mineral cinnabar race cinnabar, and master contains cinnabar( hgS).[nature and flavor] are sweet, are slightly cold; Poisonous.[ gui Jing] return heart channel.[function cures mainly] clears away heart-fire relieving convulsion, removing toxic substances of calming the nerves.For palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsygo mad, infantile convulsion, blurring of vision, aphtha, sore throat, sore swollen toxin.

Trimeresurus stejnegeri: Trimeresurus stejnegeri (Trimeresurus stejnegeri) is crotalinaeone, belong to Trimeresurus stejnegeri belong to.Have another name called trimeresurus stejnegeri, burnt tail.Trimeresurus stejnegeri is a kind of beauty poisonous snake! Whole body is emerald green, eyesmajority is yellow or red, and pupil is a vertical line, and a little as the eyes of cat, tail is burnt red, and ornamental value is high.Head is large, triangle, and neck is thin, and head and neck is distinguished obviously.The thin squama of crown tool; Between the nose of left and right, squama is not tangent, by thin squama separately; The equal delamination except outermost a line of back of the body squama, stage casing 19-21(is even 23) OK.Except minority is oviparityoutward, most kind is ovoviviparity.Effect: sore-toxin dispersing, wind dispelling insecticide, heat reliving and toxin-eliminating, nebula removing.

Eupolyphaga Seu Steleophaga: [source] this product is Corydiidae insecticide eupolyphoge sinensis Eupolyphaga sinensis Walker or Ji eupolyphoge sinensis Steleophaga plancyi(Boleny) female worm dry body.[nature and flavor] are salty, cold; Slightly poisonous.[return through] returns Liver Channel.[function cures mainly] removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.

Indigo Naturalis: [another name] indigo, indigo flower, indigo foam, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait), [source] this product is that the leaf of acanthaceous vegetable acanthaceous indigo Baphicacanthus cusia (Nees) Bremek., polygonaceae plant polygonum tinctorium ait. Polygonum tinctorium Ait. or cruciferae isatis Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.[character] this product is navy blue powder, and body is light, easily flies upward; Or in irregular porous agglomerate, with hand rubbing twist with the fingers smalls.Micro-have careless stink smell, lightly seasoned.

Radix Notoginseng: [source] this product is the dry root of panax araliaceae plant Panax notoginseng (Burk.) F. H. Chen.[nature and flavor] sweet, micro-hardship, temperature.[return through] returns liver, stomach warp.[function cures mainly] dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.

Rhizoma Imperatae: [another name] silk rhizoma Imperatae, Rhizoma Imperatae, rhizoma Imperatae, root of couch grass[source] this product is grass Herba Imperataethe dry rhizome of Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb..[nature and flavor] are sweet, cold.[ gui Jing] return lung, stomach, bladderwarp.[function cures mainly] cooling blood for hemostasis, heat clearing awaydiuresis.For heat in bloodspit blood, epistaxis, hematuria, calenturaexcessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Pseudobulbus Bletillae (Rhizoma Bletillae): [another name] Bletilla striata (Thunb.ex A.Murray)Rchb.f., Pseudobulbus Bletillae (Rhizoma Bletillae), Cold boiled chicken, Cold boiled chicken baby, Lian Jicao, YANGJIAOQI, [source] this product is orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata(Thunb.) dry tuber of Reichb. f..[nature and flavor] are bitter, sweet, puckery, are slightly cold.[return through] returns lung, liver, stomach warp.[function cures mainly] astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.

Rhizoma Acori Graminei: [another name] Folium Acori graminei, mountain Rhizoma Acori Graminei, water Rhizoma Acori Graminei, white flag, medicine Rhizoma Acori Graminei, [source] this product is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.[nature and flavor] are pungent, bitter, temperature.

[return through] GUIXIN, stomach warp.[function cures mainly] removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.

Cornu rhinocerotis: [another name] Cornu rhinocerotis [source] Rhinocerotidae animal Rhinoceros unicornis Rhinoceros unicornis L., rhinoceros sondaicus R. sondaicus Desmarest, rhinoceros sumatrensis R. sumatrensis Cuvier, black rhinoceros R. bicornis L. and white rhinoceros R. simus Cottoni etc., is used as medicine with angle.[nature and flavor] are bitter, sour, salty, cold.[function cures mainly] clearing away heat and cooling blood, removing toxic substances arresting convulsion.For calentura unconsciousness and delirium, macule, spits blood, epistaxis.[extracts] " national Chinese herbal medicine compilation ".

Cornu Bubali: [source] this product is the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.[nature and flavor] are bitter, cold.[return through] GUIXIN, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For the high heat of epidemic febrile disease, unconsciousness and delirium, sends out speckle dermexanthesis, hematemesis and epistaxis, infantile convulsion, demented.

The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and the method usually adopting people to know in the art comprises the steps:

1) each raw material weight proportioning is taken by following: Cornu Saigae Tataricae 15 ~ 20g, Herba Hedyotidis Diffusae 20 ~ 30g, Herba Scutellariae Barbatae 20 ~ 30g, Pseudobulbus Cremastrae Seu Pleiones 20 ~ 30g, Radix Scrophulariae 10 ~ 15g, Radix Arnebiae (Radix Lithospermi) 20 ~ 30g, Concha Margaritifera 20 ~ 30g, Cinnabaris 3 ~ 5g, Trimeresurus stejnegeri 20 ~ 30g, Eupolyphaga Seu Steleophaga 10 ~ 15g, Indigo Naturalis 10 ~ 15g, Radix Notoginseng 5 ~ 10g, Rhizoma Imperatae 20 ~ 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15g, Rhizoma Acori Graminei 15 ~ 20g, Cornu rhinocerotis 12 ~ 18g, Cornu Bubali 40 ~ 60g;

2) first Trimeresurus stejnegeri to be soaked in water 24 ~ 48 hours stand-by;

3) Cornu Saigae Tataricae, Cornu rhinocerotis, Cornu Bubali are put in warm water and soaked, pull out, dry, be ground into fine powder, mix thoroughly, removal of contamination;

4) by step 2) in soaked Trimeresurus stejnegeri take out and decoct with water secondary with step 3) gained fine powder together with Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Pseudobulbus Cremastrae Seu Pleiones, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Concha Margaritifera, Cinnabaris, Eupolyphaga Seu Steleophaga, Indigo Naturalis, add water 5 times amount for the first time, decoct 4 hours, add water 3 times amount for the second time, decoct 2 hours, merge extractive liquid, filter, it is 1.15 ~ 1.20 that filtrate is concentrated into relative density, adding ethanol to alcohol content is 65%, stirs, and cold preservation leaves standstill, filter, decompression filtrate recycling ethanol is to being concentrated into thick paste without alcohol taste;

5) Radix Notoginseng weighed up, Rhizoma Imperatae, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Acori Graminei are added 75% alcohol reflux secondary, first time adds alcohol 6 times amount, refluxes 1.5 hours, second time adds alcohol 4 times amount, refluxes 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, to without alcohol taste, continues to be concentrated into thick paste;

6) above-mentioned two kinds of thick pastes are merged, dry, pulverize, obtain the active component of medicine of the present invention, by polyethylene glycol 6000 heating and melting in a water bath, after whole melting, add gained active component, stirring and dissolving, 80 mesh screen, keep 60 DEG C of instillations to be chilled in the liquid paraffin of less than 10 DEG C and make pill.

Instructions of taking: medicine of the present invention can according to according to the body weight of patient and disease condition with 8 ~ 18g/ people/sky administration, these dosage can natural gift be taken for 2 times, each 1 time sooner or later, a course for the treatment of three Mondays, after the course for the treatment of inactive 1 week.

beneficial effect

The present invention is a kind of, and to treat the formula of Chinese materia medica preparation of main lymphoid leukemia scientific and reasonable, can make that its drug effect is not fully exerted, side effect is low, particularly pill, has therapeutical effect to have the remarkable result of extending life to patients with terminal to early metaphase lymphoid leukemia.Efficacy of drugs is remarkable, and Therapeutic Method is easy, is applicable to patient's self-medication.And Chinese medicine preparation of the present invention is reach medical circle " can eliminate leukemia tumor cells, normal tissue again without fatal toxic and side effects, and can recover the function of each hemopoietic system to the ideal scheme of the expection process of leukemia treating." there is wide rosy prospect to treatment leukemia, greatly reduce the ability to shoulder economically of " leukemia " patient, allow most of patient have the chance of disease therapy.In addition the leukemic sickness rate of China and even the world is higher, therefore can produce good economic benefit and social benefit, wide market.

Detailed description of the invention

Embodiment 1

Raw material: Cornu Saigae Tataricae 18g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Pseudobulbus Cremastrae Seu Pleiones 30g, Radix Scrophulariae 15g, Radix Arnebiae (Radix Lithospermi) 30g, Concha Margaritifera 30g, Cinnabaris 5g, Trimeresurus stejnegeri 30g, Eupolyphaga Seu Steleophaga 15g, Indigo Naturalis 15g, Radix Notoginseng 10g, Rhizoma Imperatae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Acori Graminei 20g, Cornu rhinocerotis 15g, Cornu Bubali 50g.

Preparation:

1) each raw material weight proportioning is taken by following: Cornu Saigae Tataricae 18g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Pseudobulbus Cremastrae Seu Pleiones 30g, Radix Scrophulariae 15g, Radix Arnebiae (Radix Lithospermi) 30g, Concha Margaritifera 30g, Cinnabaris 5g, Trimeresurus stejnegeri 30g, Eupolyphaga Seu Steleophaga 15g, Indigo Naturalis 15g, Radix Notoginseng 10g, Rhizoma Imperatae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Acori Graminei 20g, Cornu rhinocerotis 15g, Cornu Bubali 50g;

2) first Trimeresurus stejnegeri to be soaked in water 24 ~ 48 hours stand-by;

embodiment 2

Raw material: Cornu Saigae Tataricae 20g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Pseudobulbus Cremastrae Seu Pleiones 30g, Radix Scrophulariae 15g, Radix Arnebiae (Radix Lithospermi) 30g, Concha Margaritifera 30g, Cinnabaris 5g, Trimeresurus stejnegeri 30g, Eupolyphaga Seu Steleophaga 15g, Indigo Naturalis 15g, Radix Notoginseng 10g, Rhizoma Imperatae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Acori Graminei 20g, Cornu rhinocerotis 18g, Cornu Bubali 60g.

Prepare identical with embodiment 1 with instructions of taking.

embodiment 3

Raw material: Cornu Saigae Tataricae 15g, Herba Hedyotidis Diffusae 20g, Herba Scutellariae Barbatae 20g, Pseudobulbus Cremastrae Seu Pleiones 20g, Radix Scrophulariae 10g, Radix Arnebiae (Radix Lithospermi) 20g, Concha Margaritifera 20g, Cinnabaris 3g, Trimeresurus stejnegeri 20g, Eupolyphaga Seu Steleophaga 10g, Indigo Naturalis 10g, Radix Notoginseng 5g, Rhizoma Imperatae 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Rhizoma Acori Graminei 15g, Cornu rhinocerotis 12g, Cornu Bubali 40g.

Prepare identical with embodiment 1 with instructions of taking.

In order to show the therapeutic effect of Chinese medicine preparation of the present invention, invention has been clinical trial.

A kind of clinical trial for the treatment of the Chinese medicine preparation of main lymphoid leukemia proposed by the invention is as follows:

Select age 9-55 year patient example, the course of disease 3 months-6 months, average course of disease 4 months.The Chinese medicine preparation therapeutic modality of the present invention that 20 routine patients adopt is treated simultaneously, after one month, carry out symptom score.In 20 routine patients, oral during treatment, amount to 18g 2 times on the one, each 1 time of point morning and evening, each 9g takes one month continuously.

Therapeutic effect (see table):

[(80-44)/80]*100％＝45％。

As shown in Table 1, Chinese medicine preparation of the present invention, after 20 routine patients take, all takes an evident turn for the better to bone joint pain, liver spleen and lymphadenectasis, hemorrhage, anemia.

model case

Case 1 chapter, male, 50 years old, occupation: be engaged in agriculture, [main suit] because of pale complexion, cardiopalmus, breathe hard, bone joint pain, lower limbs edema, after swollen, food, the symptom such as glutted is admitted to hospital.Be diagnosed as afterwards: chronic lymphocytic leukemia, have a medical check-up through [physical examination]: skin is dispersed in petechia, superficial lymph knot (-), liver spleen do not lay one's hand on and, remaining (-).[auxiliary examination] is admitted to hospital routine of having a blood test: wbc:280*10 9/L, Hb:105g/L, plt:25*10 9/L.Bone Marrow Cell Morphology: nucleated cell polar hyperplasia, grain system 95%, former grain 35% of classifying, all the other are that red is suppressed, and megalokaryocyte has no with next stage (middle late children and shaft-like equal showed increased).Because of the non-row streaming of patient's economic cause, introduce through others afterwards and use Chinese medicine preparation of the present invention, every natural gift are taken for 2 times, each 1 time sooner or later, each 9g, within 3 weeks, be 1 course for the treatment of, after taking 2 courses for the treatment of, lower limbs edema, swollen disappear after through hospital's B ultrasonic no abnormality seen, coagulation function is all normal, adhere to taking again 2 the course for the treatment of stable disease, be still living and in good health so far.

Case 2 what certain, female, 18 years old, student, people from Zhenghai, Zhejiang, patient accompanied more than melena June because arranging epigastrium pain stomachache continuously several times.There is epigastrium pain without obvious inducement, in discontinuity pain, without the molding of acid regurgitation belch, become thin over the past half year obviously.After local hospital inspection, leukemia is diagnosed as in May, 2013, with the radiotherapy of After-market the People's Hospital, temporarily take a turn for the better after chemotherapy, but rise in November, 2013 occur that defecation blocks, bone and arthralgia, perineal position pain, lower limb the most common with skin, gingiva, nasal bleeding edema, bring into use Chinese medicine preparation of the present invention with in November, 2013 received treatment of Chinese herbs, every natural gift are taken for 2 times, and each 1 time sooner or later, each 9g 3 weeks is 1 course for the treatment of.After two courses for the treatment of, do not block without melena, defecation; There is not bleeding in skin, gingiva, nasal cavity, the mental status is good always, can also take care of oneself, and current stable disease, is still living and in good health so far.

Case 3 weeks certain, female, 45 years old, patient's in JIUYUE, 2012 is unfortunate was diagnosed as acute lymphatic leukemia, liver spleen and lymphadenectasis, heating, pharyngalgia, the dermal ecchymosis petechia 3 weeks, gross hematuria 1 week; And then done chemotherapeutic treatment, occur headache, leg osteoarthrosis pain after chemotherapy, stomach discomfort, blood pressure height waits side effect, and health is quickly in the flue many, and spirit is not good enough.Therefore abandon western medical treatment, after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention on October 5th, 2012, the state of an illness takes a turn for the better to some extent, and bone joint pain reduces, pale complexion, cardiopalmus, breathe hard, lower limb edemaalso have obvious change, the mental status takes a turn for the better to some extent, death in November, 14, with this medicine extending life more than 2 years.

Claims

1. treat the Chinese medicine preparation of main lymphoid leukemia for one kind, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight proportioning: Cornu Saigae Tataricae 15 ~ 20g, Herba Hedyotidis Diffusae 20 ~ 30g, Herba Scutellariae Barbatae 20 ~ 30g, Pseudobulbus Cremastrae Seu Pleiones 20 ~ 30g, Radix Scrophulariae 10 ~ 15g, Radix Arnebiae (Radix Lithospermi) 20 ~ 30g, Concha Margaritifera 20 ~ 30g, Cinnabaris 3 ~ 5g, Trimeresurus stejnegeri 20 ~ 30g, Eupolyphaga Seu Steleophaga 10 ~ 15g, Indigo Naturalis 10 ~ 15g, Radix Notoginseng 5 ~ 10g, Rhizoma Imperatae 20 ~ 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15g, Rhizoma Acori Graminei 15 ~ 20g, Cornu rhinocerotis 12 ~ 18g, Cornu Bubali 40 ~ 60g.

2. the Chinese medicine preparation of the main lymphoid leukemia for the treatment of according to claim 1, it is characterized in that, it is mixed with by the raw material of Chinese medicine of following weight proportioning: Cornu Saigae Tataricae 18g, Herba Hedyotidis Diffusae 30g, Herba Scutellariae Barbatae 30g, Pseudobulbus Cremastrae Seu Pleiones 30g, Radix Scrophulariae 15g, Radix Arnebiae (Radix Lithospermi) 30g, Concha Margaritifera 30g, Cinnabaris 5g, Trimeresurus stejnegeri 30g, Eupolyphaga Seu Steleophaga 15g, Indigo Naturalis 15g, Radix Notoginseng 10g, Rhizoma Imperatae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Rhizoma Acori Graminei 20g, Cornu rhinocerotis 15g, Cornu Bubali 50g.

3. the preparation method of the Chinese medicine preparation of the main lymphoid leukemia for the treatment of according to claim 1, it is characterized in that, the method comprises the steps:

2) first Trimeresurus stejnegeri to be soaked in water 24 ~ 48 hours stand-by;

6) merge above-mentioned two kinds of thick pastes, dry, pulverize, obtain the active component of medicine of the present invention, by polyethylene glycol 6000 heating and melting in a water bath, after whole melting, add gained active component, stirring and dissolving, 80 mesh screen, keep 60 DEG C of instillations to be chilled in the liquid paraffin of less than 10 DEG C and make pill.