CN104491182A - Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method - Google Patents

Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method Download PDF

Info

Publication number
CN104491182A
CN104491182A CN201510008523.5A CN201510008523A CN104491182A CN 104491182 A CN104491182 A CN 104491182A CN 201510008523 A CN201510008523 A CN 201510008523A CN 104491182 A CN104491182 A CN 104491182A
Authority
CN
China
Prior art keywords
parts
chemotherapy
radix astragali
fructus
fine powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510008523.5A
Other languages
Chinese (zh)
Inventor
李宏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510008523.5A priority Critical patent/CN104491182A/en
Publication of CN104491182A publication Critical patent/CN104491182A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine for reducing the side effects of chemotherapy and a preparation method. The traditional Chinese medicine is prepared from the following major active pharmaceutical ingredients in parts by weight: 20-30 parts of radix astragali, 10-20 parts of fructus lycii, 9-15 parts of fructus leonuri, 10-16 parts of radix puerariae, 10-16 parts of concha arcae, 8-12 parts of fructus aurantii, 6-15 parts of trichosanthes kirilowii, 8-16 parts of drumfish bladder, 9-12 parts of herba salviae chinensis, 9-15 parts of hedyotis diffusa, 10-15 parts of radix glycyrrhizae, 6-10 parts of japonese pearlwort herb and 5-9 parts of hericium erinaceus. Through the traditional Chinese medicine disclosed by the invention, the pain of a patient can be relieved, the survival time of the patient is effectively prolonged, and the quality of life is improved; the immune function of the body can be enhanced, and general conditions of the patient can be obviously improved; and in cooperation with chemotherapy, the toxic and side reactions of chemotherapy can be obviously relieved so as to improve the tolerance of the patient to the chemotherapy and promote successful implementation of chemotherapy.

Description

Alleviate Chinese drugs agentia and the preparation method of chemotherapy side effect
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese drugs agentia and the preparation method that alleviate chemotherapy side effect.
Background technology
Current treatment of cancer is main or treat based on " operation, chemotherapy, radiotherapy ", operation is the first-selection treatment way of Therapeutic cancer, but, it has been late period time a lot of Finding case obtains cancer, lose the chance of operation, chemicotherapy can only be selected to treat, but the toxic and side effects of chemotherapy is very large, how alleviating the toxic and side effects that chemotherapy is brought, has been the puzzlement of a lot of patient.Normal cell also can kill by chemotherapy while killing cancerous cell, can also cause the side effect such as gastrointestinal dysfunction, bone marrow depression, greatly reduces the life quality of patient.The side effect of chemotherapy mainly contains: one, bone marrow depression, refers to the activity decrease of the blood cell precursors in bone marrow, cannot proper splitting, makes the hemoglobin in blood, leukocyte, all subnormal scope of granulocyte and platelet etc.Two, digestive tract reaction, gastral symptom is all quite common as loss of appetite, nausea,vomiting,diarrhea etc., and what have even can continue more than 1 week.Three, neural murder by poisoning, relevant with total amount, heavy dose of and repeatedly medication time obvious, damage ear Ke, for the hair cell of mouthpart, causes high frequency to lose and listens, at the giddy of some patients, tinnitus, deafness, high frequency hearing disability; A few peoples show as retrobulbar neuritis, paraesthesia, gustatory anesthesia.Four, lesions of liver and kidney, chemotherapeutics can cause injury of kidney sometimes, occurs that transaminase raises.Other side effect such as health is weak, and whole body fatigue and weak, lethargy, cold perspiration, drowsiness etc. can appear in patient.Immunologic function also can decline to a great extent in addition.
In order to the toxic and side effects alleviating chemotherapeutics can use many kinds of measures.Change route of administration, in some tumor, on other occasions, breast, intraperitoneal administration can be adopted, arterial perfusion, local injection in tumor, " the half body chemotherapy " of limbs Cardiopulmonary bypass or blocking-up ventral aorta, to hope the drug level improving tumor by local, reduce the blood drug level of systemic circulation system, reduce the general toxicity of chemotherapeutics.Component blood transfusion, in chemotherapy of tumors, hematological toxicity leukocyte and thrombocytopenia the most common, can cause time serious infecting and hemorrhage, the leukocyte that infusion is concentrated if desired or platelet component blood can prevent and treat seriously infection and hemorrhage.Bone marrow transplantation, peripheral stem cell transplantation.The autologous bone alkali of the many employings of solid-tumor chemotherapy is transplanted, Autologous peripheral blood stem cell transplantation.Dietary adjustments, during chemotherapy, appetite is often poor, has again feeling sick grade for reaction, requires dining number of times more than usual, preferably rare soft digestible food, but reach high protein, vitamin enriches, the requirement of heat energy abundance, Here it is " fewer but better " that people say, if food-intake is inadequate, by supplementary glucose, vitamin, the aminoacid of infusing, give albumin if desired.Chinese medicine regulates, and Chinese medicine is ginsenoside rh2 such as, Ganoderma and some other material that can strengthen body immunity, and use the Traditional Chinese Medicine methods such as determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, combined with chemotherapy, radiotherapy etc. reach increase curative effect, can alleviate radiotherapy, chemical therapy toxic side effect.
Application publication number CN 104055802 A(application number 201410243030.5) Chinese patent literature disclose a kind of medicine reducing tumor chemoradiotherapy side effect.The medicine of this reduction tumor chemoradiotherapy side effect, is made by certain parts by weight for active component with Zinc-enriched selenium-enriched dried whole-egg, lentinan, Cordyceps militaris (L.) Link. and vitamin E.Publication number CN 101411843A(application number 200710189792.1) Chinese patent literature disclose a kind of medicine eliminating toxic and side effects of chemoradiotherapy, be prepared from by the raw material of following weight: Rhizoma Atractylodis Macrocephalae (parched) 10-20, Radix Ginseng Rubra 10-20, Poria 10-20, Fructus Crataegi (parched to brown) 10-20, Fructus Setariae Germinatus (parched) 10-20, Massa Medicata Fermentata 10-20, Endothelium Corneum Gigeriae Galli 5-10, Pericarpium Citri Reticulatae 10-20, Fructus Amomi 5-10, Radix Aucklandiae 10-20.Publication number CN 101199596A(application number 200710303706.5) Chinese patent literature disclose and a kind ofly alleviate Chinese medicine composition of cancer Radiotherapy chemotherapy toxic and side effects and preparation method thereof, it is made primarily of Cordyceps, Ganoderma, Radix Ginseng Rubra, Radix Angelicae Sinensis, the Radix Astragali and Fructus Schisandrae Chinensis.
Chemotherapy both can anticancer, but also can kill and wound normal cell, and quality of life is declined, and Chang Yin toxic and side effects in various degree, cause some patients and can not complete each course for the treatment of smoothly, have impact on curative effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese drugs agentia and the preparation method that alleviate chemotherapy side effect.The present invention can alleviate patient suffering, effectively extends the survival of patients time, promotes quality of life; Can enhancing human body immunity function, obviously can improve the general status of patient; Combined with chemotherapy of the present invention obviously can alleviate chemotherapy toxic side effect, and then improves patient to the toleration of chemotherapy, helps chemotherapy to complete smoothly.
Technical scheme of the present invention is:
Alleviate the Chinese drugs agentia of chemotherapy side effect, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Astragali 20-30, Fructus Lycii 10-20, Fructus Leonuri 9-15, Radix Puerariae 10-16, Concha Arcae 10-16, Fructus Aurantii 8-12, Fructus Trichosanthis 6-15, Shishou Air Bladder pseudosciaenae seu Acipenser 8-16, Herba Salviae Chinensis 9-12, Herba Hedyotidis Diffusae 9-15, Radix Glycyrrhizae 10-15, Herba Saginae Japonicae 6-10, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-9.
Alleviate the Chinese drugs agentia of chemotherapy side effect, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Astragali 23-26, Fructus Lycii 13-17, Fructus Leonuri 11-13, Radix Puerariae 12-15, Concha Arcae 11-14, Fructus Aurantii 9-11, Fructus Trichosanthis 8-12, Shishou Air Bladder pseudosciaenae seu Acipenser 10-14, Herba Salviae Chinensis 9.5-11, Herba Hedyotidis Diffusae 11-14, Radix Glycyrrhizae 11-14, Herba Saginae Japonicae 7-9, Hericium erinaceus (Bull. Ex Fr.) Pers. 6-8.
Alleviate the Chinese drugs agentia of chemotherapy side effect, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: the Radix Astragali 25, Fructus Lycii 15, Fructus Leonuri 12, Radix Puerariae 14, Concha Arcae 12, Fructus Aurantii 10, Fructus Trichosanthis 10, Shishou Air Bladder pseudosciaenae seu Acipenser 12, Herba Salviae Chinensis 10, Herba Hedyotidis Diffusae 13, Radix Glycyrrhizae 13, Herba Saginae Japonicae 8, Hericium erinaceus (Bull. Ex Fr.) Pers. 7.
Present invention also offers the preparation method above-mentioned Chinese drugs agentia alleviating chemotherapy side effect being made pharmaceutically acceptable decoction, powder and pill.
The preparation method of described decoction is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, is ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds the preferred every 100kg Radix Astragali of yellow wine 20-28kg(and adds yellow wine 24kg), mix thoroughly, in tank filling, airtight, put in water-bath, water intaking is stewed, and midway is stirred once, is sucked to wine, and taking-up, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12-25 minute (preferably put in food steamer and steam 17 minutes), flatten, be cut into block, dry, be ground into fine powder;
(4) Concha Arcae is smashed, put into marmite, add water, amount of water is 2.5-3.5 times (preferred amount of water is 3 times of Concha Arcae weight) of Concha Arcae weight, first boil with high heat to boiling, after turn slow fire boiling 60-80 minute (preferably, turning slow fire boiling 70 minutes), leach medicinal liquid;
(5) all the other the 9 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali, Fructus Trichosanthis and Concha Arcae are cleaned respectively, put into above-mentioned marmite, add water, amount of water is 4-6 times (preferred amount of water is 5 times of 9 taste medical material gross weights) of 9 taste medical material gross weights, first boil with high heat to boiling, after turn slow fire boiling 40-55 minute (preferably then turn slow fire boiling 45 minutes), leach medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, then step (1), step (2) and step (3) gained fine powder are added.
The preparation method of powder is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve Pulvis Talci, cools, be ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds the preferred every 100kg Radix Astragali of yellow wine 20-28kg(and adds yellow wine 24kg), mix thoroughly, in tank filling, airtight, put in water-bath, water intaking is stewed, and midway is stirred once, is sucked to wine, and taking-up, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12-25 minute (preferably put in food steamer and steam 17 minutes), flatten, be cut into block, dry, be ground into fine powder;
(4) all the other the 10 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali and Fructus Trichosanthis are ground into fine powder respectively;
(5) step (1), step (2), step (3) and step (4) gained fine powder are mixed, sterile packaged and get final product.
The preparation method of described pill is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve Pulvis Talci, cools, be ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds the preferred every 100kg Radix Astragali of yellow wine 20-28kg(and adds yellow wine 24kg), mix thoroughly, in tank filling, airtight, put in water-bath, water intaking is stewed, and midway is stirred once, is sucked to wine, and taking-up, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12-25 minute (preferably put in food steamer and steam 17 minutes), flatten, be cut into block, dry, be ground into fine powder;
(4) all the other the 10 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali and Fructus Trichosanthis are ground into fine powder respectively;
(5) step (1), step (2), step (3) and step (4) gained fine powder are fully mixed;
(6) first the little fire of Mel is heated to micro-boiling, removes the foam on the upper strata of boiling out, stop heating, and while hot step (5) gained medicated powder is added in Mel, the weight of Mel is 1.6-2 times (weight of preferred Mel is 1.7 times of medicated powder weight) of medicated powder weight, stirs, after cooling, with become dough, be twisted into strip, cutting, group's ball, drying, the heavy 0.2-0.4g(of every ball is the heavy 0.3g of every ball preferably).
The Chinese drugs agentia alleviating chemotherapy side effect provided by the invention adopts the Chinese crude drug of pure natural, and medicine source is easy to get, and the preparation method of various dosage form is simple, products obtained therefrom taking convenience.In addition, excellent results of the present invention also shows:
1, alleviate patient suffering, effectively extend the survival of patients time, promote quality of life;
2, there is the effects such as invigorating QI to consolidate the body surface resistance, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, can enhancing human body immunity function, obviously can improve the general status of patient;
3, combined with chemotherapy of the present invention obviously can alleviate chemotherapy toxic side effect, and then improves patient to the toleration of chemotherapy, side
Chemotherapy is helped to complete smoothly;
, effectively, have no side effect 4, safely.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Astragali: base is former: be the dry root of leguminous plant Radix Astagali or Radix Astragali.The property of medicine: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Fructus Lycii: base is former: be the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.The property of medicine: sweet, flat.Return liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Fructus Leonuri: base is former: be the fruit of Labiatae mother wort plant Herba Leonuri and Herba Leonuri Sibirici.Composition: leonuri,fructus contains allene class fatty acid containing alkaloid, herb containing phenolic glycoside class, Herba Leonuri Sibirici fruit kind oil.Pharmacology: have hypotensive effect, has the effect of stimulon palace excitement.The property of medicine: sweet, pungent, is slightly cold, mild toxicity.Return Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.
Radix Puerariae: base is former: be the dry root of legume pueraria lobata.The property of medicine: sweet, pungent, cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, hypertension neck pain.
Concha Arcae: base is former: be the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa or Scapharca subcrenata.The property of medicine: sweet, salty, flat.Return liver, spleen channel.Function cures mainly: reduce phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Control accumulation of phlegm, stomachache, noisy, acid regurgitation, lump in the abdomen, scrofula, ulcerative gingivitis.
Fructus Aurantii: base is former: be the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..The property of medicine: bitter, sour, is slightly cold.Return lung, spleen, liver, stomach, large intestine channel.Function cures mainly: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.
Fructus Trichosanthis: another name Fructus Trichosanthis, Gua Lou, medicine melon is the fruit of Cucurbitaceae Trichosanthes Fructus Trichosanthis and trichosanthes rosthornii Harms.The property of medicine: sweet, micro-hardship, cold.Return lung, stomach, large intestine channel.Function cures mainly: removing heat-phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.Cure mainly cough due to lung-heat, the thoracic obstruction, blocked-up chest, quench one's thirst, constipation, carbuncle sore tumefacting virus.
Shishou Air Bladder pseudosciaenae seu Acipenser: base is former: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.The property of medicine: sweet, flat.Return kidney, Liver Channel.Function cures mainly: the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Control spermatorrhea of suffering from a deficiency of the kidney, puerperal puerperal tetanus, tetanus, spit blood, metrorrhagia, wound hemorrhage, hemorrhoid.
Herba Salviae Chinensis: base is former: be the herb of labiate Herba Salviae Chinensis.Chemical analysis: herb is containing sterol, Triterpenoid, aminoacid.Root is containing stachyose.The property of medicine: pungent, bitter, is slightly cold.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating.Main menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, has blood in stool, jaundice due to damp-heat, hot toxic-heat and blood stasis, drenches pain, leukorrhagia, rheumatic ostalgia, scrofula, and skin ulcer swells, acute mastitis, herpes zoster, leprosy, and traumatic injury wound is swollen.
Herba Hedyotidis Diffusae: base is former: be the whole herb with root of Radix Rubiae kind of plant Herba Hedyotidis Diffusae.Chemical analysis: separate 1 alkane, stigmasterol, ursolic acid, oleanolic acid in herb, cupreol, cupreol-D-Glucose glycoside, P-coumaric acid etc.The property of medicine: bitter, sweet, cold." Guangxi Chinese medicinal herbal ": " entering the heart, liver, spleen three warp " function cures mainly: heat clearing away, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Pharyngolaryngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom, tumor.Also can be used for alimentary tract cancer.
Radix Glycyrrhizae: base is former: be the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..The property of medicine: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Saginae Japonicae: base is former: be the herb of Caryophyllaceae sagina Herba Saginae Japonicae.Composition: containing volatile oil, the sweet and flavone of soap.Pharmacology: the effect with low anticancer, has antitussive, clears phlegm.The property of medicine: bitter, pungent, cool.Return liver, stomach warp.Function cures mainly: removing pathogenic heat from blood and toxic substance from the body, killing parasites for relieving itching.Main dermatitis rhus, tinea alba, eczema, erysipelas, scrofula, innominate toxic swelling, venom, nasal sinusitis, caries pain, internal traumatic injury.
Hericium erinaceus (Bull. Ex Fr.) Pers.: another name monkey mushroom, hedgehog bacterium, Rrinaceus earopaeus bacterium, Hericium caput-medusae, Hericium erinaceus (Bull. Ex Fr.) Pers. are the sporophore of hedgehog fungus section fungus Hericium erinaceus (Bull. Ex Fr.) Pers., Hydnum.The property of medicine: sweet, flat.Return spleen, stomach warp.Function cures mainly: strengthening the spleen and nourishing the stomach, calms the nerves, anticancer.Main body void is weak, dyspepsia, insomnia, gastroduodenal ulcer, chronic gastritis, digestive tract tumor.
embodiment 1alleviate the Chinese drugs agentia of chemotherapy side effect, the primary raw material medicine getting following weight parts is prepared from (every part is 50g): the Radix Astragali 20 parts, Fructus Lycii 10 parts, Fructus Leonuri 9 parts, Radix Puerariae 10 parts, Concha Arcae 10 parts, Fructus Aurantii 8 parts, Fructus Trichosanthis 6 parts, 8 parts, Shishou Air Bladder pseudosciaenae seu Acipenser, Herba Salviae Chinensis 9 parts, Herba Hedyotidis Diffusae 9 parts, 10 parts, Radix Glycyrrhizae, Herba Saginae Japonicae 6 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 5 parts.
The above-mentioned preparation method alleviating the Chinese drugs agentia decoction of chemotherapy side effect is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, is ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds yellow wine 20kg, mixes thoroughly, in tank filling, airtight, puts in water-bath, and water intaking is stewed, and midway is stirred once, is sucked to wine, takes out, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12 minutes, flatten, be cut into block, dry, be ground into fine powder;
(4) smashed by Concha Arcae, put into marmite, add water, amount of water is 2.5 times of Concha Arcae weight, first boils with high heat to boiling, after turn slow fire boiling 60 minutes, leach medicinal liquid;
(5) cleaned respectively by all the other the 9 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali, Fructus Trichosanthis and Concha Arcae, put into above-mentioned marmite, add water, amount of water is 4 times of 9 taste medical material gross weights, first boils with high heat to boiling, after turn slow fire boiling 40 minutes, leach medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, then step (1), step (2) and step (3) gained fine powder are added.
The present invention alleviates the using method of the Chinese drugs agentia decoction of chemotherapy side effect: every day twice, and each 230mL(is warm).
embodiment 2alleviate the Chinese drugs agentia of chemotherapy side effect, the primary raw material medicine getting following weight parts is prepared from (every part is 50g): the Radix Astragali 30 parts, Fructus Lycii 20 parts, Fructus Leonuri 15 parts, Radix Puerariae 16 parts, Concha Arcae 16 parts, Fructus Aurantii 12 parts, Fructus Trichosanthis 15 parts, 16 parts, Shishou Air Bladder pseudosciaenae seu Acipenser, Herba Salviae Chinensis 12 parts, Herba Hedyotidis Diffusae 15 parts, 15 parts, Radix Glycyrrhizae, Herba Saginae Japonicae 10 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 9 parts.
The above-mentioned preparation method alleviating the Chinese drugs agentia decoction of chemotherapy side effect is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, is ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds yellow wine 28kg, mixes thoroughly, in tank filling, airtight, puts in water-bath, and water intaking is stewed, and midway is stirred once, is sucked to wine, takes out, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 25 minutes, flatten, be cut into block, dry, be ground into fine powder;
(4) smashed by Concha Arcae, put into marmite, add water, amount of water is 3.5 times of Concha Arcae weight, first boils with high heat to boiling, after turn slow fire boiling 80 minutes, leach medicinal liquid;
(5) cleaned respectively by all the other the 9 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali, Fructus Trichosanthis and Concha Arcae, put into above-mentioned marmite, add water, amount of water is 6 times of 9 taste medical material gross weights, first boils with high heat to boiling, after turn slow fire boiling 55 minutes, leach medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, then step (1), step (2) and step (3) gained fine powder are added.
model case one:xXX, man, 54 years old.There is hoarseness without obvious inducement before 2 years, do not give attention, do not treat further, occur chest pain and sputum mixed with blood afterwards, without fear of cold, heating, without becoming thin, night sweat, without uncomfortable in chest, out of breath, occur without feed sense of choking with sobs.Look into gastroscopy pathology to show: (gastric antrum) pyloric gland mucosa chronic inflammation accompanies slight atrophy HP(+).CT shows: two pulmonary metastases, and PET-CT shows: the two multiple transfer of lung of right lung medial segment primary carcinoma companion, vertical diaphragm, right lung door and right side diaphram lymphatic metastasis.Fibre bronchus mirror+biopsy is shown: find cancerous cell (non-small cell type).Final diagnosis: the 1. two lung of right lung companion, vertical diaphragm, right lung door and the multiple transfer of right side diaphram lymph node.After carrying out chemotherapy, side effect is obvious: numeration of leukocyte is reduced to 2.68 × 10 9/ L, neutrophilic granulocyte 35%, platelet count 100 × 10 9/ L, hemoglobin 91g/L; Namely feeling sick appears in patient's first day, and vomits twice; Without appetite, 3-4 days defecations once; Without oral ulcer.Within one week before chemotherapy, use the Chinese drugs agentia decoction that the present embodiment gained alleviates chemotherapy side effect, every day twice, each 230mL(is warm).There is not side effect after carrying out chemotherapy in another, the obvious health of patient takes a turn for the better.Be embodied in: numeration of leukocyte rises to 4.0 × 10 9/ L, neutrophilic granulocyte reaches 60%, platelet 107 × 10 9/ L, erythrocyte 111g/L.Not there is the situation of feeling sick in patient, appetite starts to recover, and defecation is normal again.
embodiment 3alleviate the Chinese drugs agentia of chemotherapy side effect, the primary raw material medicine getting following weight parts is prepared from (every part is 50g): the Radix Astragali 23 parts, Fructus Lycii 13 parts, Fructus Leonuri 11 parts, Radix Puerariae 12 parts, Concha Arcae 11 parts, Fructus Aurantii 9 parts, Fructus Trichosanthis 8 parts, 10 parts, Shishou Air Bladder pseudosciaenae seu Acipenser, Herba Salviae Chinensis 9.5 parts, Herba Hedyotidis Diffusae 11 parts, 11 parts, Radix Glycyrrhizae, Herba Saginae Japonicae 7 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 6 parts.
The above-mentioned preparation method alleviating the Chinese drugs agentia powder of chemotherapy side effect is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve Pulvis Talci, cools, be ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds yellow wine 24kg, mixes thoroughly, in tank filling, airtight, puts in water-bath, and water intaking is stewed, and midway is stirred once, is sucked to wine, takes out, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 17 minutes, flatten, be cut into block, dry, be ground into fine powder;
(4) all the other the 10 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali and Fructus Trichosanthis are ground into fine powder respectively;
(5) step (1), step (2), step (3) and step (4) gained fine powder are mixed, sterile packaged and get final product.
model case two:xXX, female, 59 years old.Patient's private prosecution was diagnosed as pulmonary carcinoma before 4 years, oneself can feel feeling funny after operation, chemotherapy.After undergoing surgery, receive again the chemotherapy of 9 courses for the treatment of.Beat first 3 days of chemotherapy each time free, just can't have dinner afterwards.Examine and see that patient's face blue, both sides tongue fur are all blue.Take the Chinese drugs agentia powder that the present embodiment gained alleviates chemotherapy side effect, every day twice, each 4g, boiled water is taken after mixing it with water.Take 5 days, can meal be eaten.After taking 1 month, health is clearly better, and again accepts chemotherapy, after chemotherapy, has no adverse reaction.
embodiment 4alleviate the Chinese drugs agentia of chemotherapy side effect, the primary raw material medicine getting following weight parts is prepared from (every part is 50g): the Radix Astragali 26 parts, Fructus Lycii 17 parts, Fructus Leonuri 13 parts, Radix Puerariae 15 parts, Concha Arcae 14 parts, Fructus Aurantii 11 parts, Fructus Trichosanthis 12 parts, 14 parts, Shishou Air Bladder pseudosciaenae seu Acipenser, Herba Salviae Chinensis 11 parts, Herba Hedyotidis Diffusae 14 parts, 14 parts, Radix Glycyrrhizae, Herba Saginae Japonicae 9 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 8 parts.
The above-mentioned preparation method alleviating the Chinese drugs agentia pill of chemotherapy side effect is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve Pulvis Talci, cools, be ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds yellow wine 24kg, mixes thoroughly, in tank filling, airtight, puts in water-bath, and water intaking is stewed, and midway is stirred once, is sucked to wine, takes out, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 17 minutes, flatten, be cut into block, dry, be ground into fine powder;
(4) all the other the 10 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali and Fructus Trichosanthis are ground into fine powder respectively;
(5) step (1), step (2), step (3) and step (4) gained fine powder are fully mixed;
(6) first the little fire of Mel is heated to micro-boiling, removes the foam on the upper strata of boiling out, stop heating, and while hot step (5) gained medicated powder is added in Mel, the weight of Mel is 1.7 times of medicated powder weight, stirs, after cooling, with become dough, be twisted into strip, cutting, group's ball, drying, the heavy 0.3g of every ball.
model case three:xXX, man, 65 years old.Before 1 year, patient is diagnosed as rectal cancer, Lung metastases.After accepting 1 course for the treatment of chemotherapy, not only have no interest in anything, also diarrhoea all day, stool band pink colour blood, stomach-ache, likes cold perspiration.Take the Chinese drugs agentia pill agent that the present embodiment gained alleviates chemotherapy side effect, every day three times, each 12 balls, warm water delivery service.Take 10 days, belly is pain no longer.After taking 20 days, stool is only with a little blood, does not originally weigh, also not original pain.After taking 1 month, again carry out chemotherapy, after chemotherapy, do not occur side effect.To local hospital check after 2 wheat harvesting periods, routine blood test, routine urinalysis are all normal.Nowadays patient can have a meal, cold perspiration, pain in the lumbar region do not alleviate, defecate and be not with blood.
embodiment 5alleviate the Chinese drugs agentia of chemotherapy side effect, the primary raw material medicine getting following weight parts is prepared from (every part is 50g): the Radix Astragali 25 parts, Fructus Lycii 15 parts, Fructus Leonuri 12 parts, Radix Puerariae 14 parts, Concha Arcae 12 parts, Fructus Aurantii 10 parts, Fructus Trichosanthis 10 parts, 12 parts, Shishou Air Bladder pseudosciaenae seu Acipenser, Herba Salviae Chinensis 10 parts, Herba Hedyotidis Diffusae 13 parts, 13 parts, Radix Glycyrrhizae, Herba Saginae Japonicae 8 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 7 parts.
The above-mentioned preparation method alleviating the Chinese drugs agentia decoction of chemotherapy side effect is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, is ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds yellow wine 24kg, mixes thoroughly, in tank filling, airtight, puts in water-bath, and water intaking is stewed, and midway is stirred once, is sucked to wine, takes out, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 17 minutes, flatten, be cut into block, dry, be ground into fine powder;
(4) smashed by Concha Arcae, put into marmite, add water, amount of water is 3 times of Concha Arcae weight, first boils with high heat to boiling, after turn slow fire boiling 70 minutes, leach medicinal liquid;
(5) cleaned respectively by all the other the 9 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali, Fructus Trichosanthis and Concha Arcae, put into above-mentioned marmite, add water, amount of water is 5 times of 9 taste medical material gross weights, first boils with high heat to boiling, after turn slow fire boiling 45 minutes, leach medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, then step (1), step (2) and step (3) gained fine powder are added.
test examplegained of the present invention alleviates the clinical practice of the Chinese drugs agentia decoction (embodiment 5) of chemotherapy side effect: in February ,-2013 in April, 2009,246 routine Patients with Middle-late Malignant Tumors are screened in 6 hospitals, and have visible focus through proved by pathology, also accept chemotherapy in hospital after making a definite diagnosis, Ka Shi scoring (KPS) is more than 60 points, more than March life cycle, wherein male 126 example, women 120 example, oldest 75 years old, minimum 32 years old of age, 61 years old mean age.Diagnosing tumor standard and by stages see " Chinese common cancer diagnosis and treatment specification " that Ministry of Health of the People's Republic of China issues.Exclusion standard: 1. do not meet above-mentioned standard; 2. psychotic; 3. allergic constitution or to multi-medicament allergy sufferers.Be divided into two groups at random, treatment group and matched group (often organizing 123 people), treatment group uses products obtained therefrom combined with chemotherapy of the present invention, matched group chemotherapy.The Chinese drugs agentia decoction that treatment group brings into use gained of the present invention to alleviate chemotherapy side effect for 1 week before chemotherapy, using method: oral, every day twice, each 230mL(is warm), within 1 month, be 1 course for the treatment of, share two courses for the treatment of.
Curative effect is observed: the leading indicator of attenuation: 1. chemicotherapy completion rate; 2. symptom improves situation; 3. radiation injury; 4. animation evaluation (Ka Shi scoring); 5. the infringement of the heart, liver, kidney and hemopoietic system.Secondary index: 1. changes in immune function; 2. other chemicotherapy untoward reaction.Efficacy determination: (1) Ka Shi marks: treatment is front and terminate to mark each course for the treatment of, after all courses for the treatment of terminate, comparatively the front scoring for the treatment of increases >=10 points of persons for " improving improvement ", it is " reduction " that scoring reduces by >=10 points of persons, and scoring increase and decrease≤10 points of persons are " stablizing ".Effectively comprise and improve and stablize.Two groups of treatments Life For The Residents of Three Gorges Reservoir Before evaluation (KPS) change as shown in table 1.(2) Evaluation of Immunity: 1. improve: after treatment, comparatively treatment is front improves >=10%, or is normal by abnormal restoring; 2. decline: after treatment, comparatively treatment is front by abnormal decline >=10%, or from normally becoming exception; 3. stablize: rise before comparatively treating after treatment, decline is less than 10% or maintain normal range.Two groups of White blood cell situations compare, as shown in table 2.(3) hepatic and renal function grade scale: grade of liver function adopts child grade scale; Endogenous creatinine clearance rate (Ccr) assessment is pressed in renal function classification, i.e. the 1st phase: Ccr51 ~ 80 ml/min, the 2nd phase: Ccr50 ~ 20 ml/min, the 3rd phase: Ccr19 ~ 10 ml/min, 4th phase: Ccr < 10 ml/min, 0 phase was the normal person of hepatic and renal function.Two groups of hepatic and renal function situations of change compare, as shown in table 3.
Table 1 liang group treatment Life For The Residents of Three Gorges Reservoir Before evaluation (KPS) change
From table 1, treatment group KPS scoring effective percentage is 97.56%, and matched group is 61.79%.Two groups are compared, and treatment group is obviously better than matched group (P < 0.05).
A table 2 liang group White blood cell situation compares
From table 2, treatment group leukocyte stablize and raise account for 96.75%, apparently higher than matched group (51.21%), difference has significance (P < 0.05).
A table 3 liang group hepatic and renal function situation of change compares
From table 3, compared with matched group, after treatment, treatment group hepatic and renal function obviously improves, and difference has significance (P < 0.05).
The present invention selects the Radix Astragali, Fructus Lycii, Fructus Leonuri and Radix Puerariae etc. to be primary raw material, makes the Chinese drugs agentia alleviating chemotherapy side effect.Radix Astragali invigorating QI to consolidate the body surface resistance in side, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Fructus Lycii nourishing kidney, lung moistening, tonifying liver, improving eyesight.Fructus Leonuri blood circulation promoting and blood stasis dispelling, liver heat removing and eyesight improving.Radix Puerariae expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Concha Arcae reduces phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Fructus Trichosanthis removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.Shishou Air Bladder pseudosciaenae seu Acipenser the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Herba Salviae Chinensis blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating.Herba Hedyotidis Diffusae heat clearing away, dampness removing, removing toxic substances.Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Herba Saginae Japonicae removing pathogenic heat from blood and toxic substance from the body, killing parasites for relieving itching.Hericium erinaceus (Bull. Ex Fr.) Pers. promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, Fructus Alpiniae Oxyphyllae of calming the nerves.All medicines share, and have the effects such as invigorating QI to consolidate the body surface resistance, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, can enhancing human body immunity function, obviously can improve the general status of patient.Combined with chemotherapy of the present invention obviously can alleviate chemotherapy toxic side effect, and then improves patient to the toleration of chemotherapy, helps chemotherapy to complete smoothly.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. alleviate the Chinese drugs agentia of chemotherapy side effect, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Astragali 20-30, Fructus Lycii 10-20, Fructus Leonuri 9-15, Radix Puerariae 10-16, Concha Arcae 10-16, Fructus Aurantii 8-12, Fructus Trichosanthis 6-15, Shishou Air Bladder pseudosciaenae seu Acipenser 8-16, Herba Salviae Chinensis 9-12, Herba Hedyotidis Diffusae 9-15, Radix Glycyrrhizae 10-15, Herba Saginae Japonicae 6-10, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-9.
2. alleviate the Chinese drugs agentia of chemotherapy side effect as claimed in claim 1, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Astragali 23-26, Fructus Lycii 13-17, Fructus Leonuri 11-13, Radix Puerariae 12-15, Concha Arcae 11-14, Fructus Aurantii 9-11, Fructus Trichosanthis 8-12, Shishou Air Bladder pseudosciaenae seu Acipenser 10-14, Herba Salviae Chinensis 9.5-11, Herba Hedyotidis Diffusae 11-14, Radix Glycyrrhizae 11-14, Herba Saginae Japonicae 7-9, Hericium erinaceus (Bull. Ex Fr.) Pers. 6-8.
3. alleviate the Chinese drugs agentia of chemotherapy side effect as claimed in claim 1, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: the Radix Astragali 25, Fructus Lycii 15, Fructus Leonuri 12, Radix Puerariae 14, Concha Arcae 12, Fructus Aurantii 10, Fructus Trichosanthis 10, Shishou Air Bladder pseudosciaenae seu Acipenser 12, Herba Salviae Chinensis 10, Herba Hedyotidis Diffusae 13, Radix Glycyrrhizae 13, Herba Saginae Japonicae 8, Hericium erinaceus (Bull. Ex Fr.) Pers. 7.
4. the Chinese drugs agentia alleviating chemotherapy side effect as described in as arbitrary in claims 1 to 3, it is characterized in that, this is made pharmaceutically acceptable decoction to the Chinese drugs agentia alleviating chemotherapy side effect, and the preparation method of described decoction is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, is ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds the preferred every 100kg Radix Astragali of yellow wine 20-28kg(and adds yellow wine 24kg), mix thoroughly, in tank filling, airtight, put in water-bath, water intaking is stewed, and midway is stirred once, is sucked to wine, and taking-up, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12-25 minute (preferably put in food steamer and steam 17 minutes), flatten, be cut into block, dry, be ground into fine powder;
(4) Concha Arcae is smashed, put into marmite, add water, amount of water is 2.5-3.5 times (preferred amount of water is 3 times of Concha Arcae weight) of Concha Arcae weight, first boil with high heat to boiling, after turn slow fire boiling 60-80 minute (preferably, turning slow fire boiling 70 minutes), leach medicinal liquid;
(5) all the other the 9 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali, Fructus Trichosanthis and Concha Arcae are cleaned respectively, put into above-mentioned marmite, add water, amount of water is 4-6 times (preferred amount of water is 5 times of 9 taste medical material gross weights) of 9 taste medical material gross weights, first boil with high heat to boiling, after turn slow fire boiling 40-55 minute (preferably then turn slow fire boiling 45 minutes), leach medicinal liquid;
(6) step (4) and step (5) gained medicinal liquid are merged, then step (1), step (2) and step (3) gained fine powder are added.
5. the Chinese drugs agentia alleviating chemotherapy side effect as described in as arbitrary in claims 1 to 3, it is characterized in that, this is made pharmaceutically acceptable powder to the Chinese drugs agentia alleviating chemotherapy side effect, and the preparation method of described powder is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve Pulvis Talci, cools, be ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds the preferred every 100kg Radix Astragali of yellow wine 20-28kg(and adds yellow wine 24kg), mix thoroughly, in tank filling, airtight, put in water-bath, water intaking is stewed, and midway is stirred once, is sucked to wine, and taking-up, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12-25 minute (preferably put in food steamer and steam 17 minutes), flatten, be cut into block, dry, be ground into fine powder;
(4) all the other the 10 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali and Fructus Trichosanthis are ground into fine powder respectively;
(5) step (1), step (2), step (3) and step (4) gained fine powder are mixed, sterile packaged and get final product.
6. the Chinese drugs agentia alleviating chemotherapy side effect as described in as arbitrary in claims 1 to 3, it is characterized in that, this is made pharmaceutically acceptable pill to the Chinese drugs agentia alleviating chemotherapy side effect, and the preparation method of described pill is:
(1) getting Pulvis Talci puts in pot, makes popular with slow fire, puts into Shishou Air Bladder pseudosciaenae seu Acipenser, and when stirring to tympanites pine bubble, take out, sieve Pulvis Talci, cools, be ground into fine powder;
(2) get the Radix Astragali, clean, add yellow wine, every 100kg Radix Astragali adds yellow wine 20-28kg, mixes thoroughly, in tank filling, airtight, puts in water-bath, and water intaking is stewed, and midway is stirred once, is sucked to wine, takes out, dries, be ground into fine powder;
(3) Fructus Trichosanthis is removed handle, clean, put in food steamer and steam 12-25 minute, flatten, be cut into block, dry, be ground into fine powder;
(4) all the other the 10 taste medical materials except Shishou Air Bladder pseudosciaenae seu Acipenser, the Radix Astragali and Fructus Trichosanthis are ground into fine powder respectively;
(5) step (1), step (2), step (3) and step (4) gained fine powder are fully mixed;
(6) first the little fire of Mel is heated to micro-boiling, removes the foam on the upper strata of boiling out, stop heating, and while hot step (5) gained medicated powder is added in Mel, the weight of Mel is 1.6-2 times of medicated powder weight, stirs, after cooling, with become dough, be twisted into strip, cutting, group's ball, drying, the heavy 0.2-0.4g of every ball.
7. alleviate the preparation method of the Chinese drugs agentia pill of chemotherapy side effect as claimed in claim 6, it is characterized in that, in step (2), every 100kg Radix Astragali adds yellow wine 24kg.
8. alleviate the preparation method of the Chinese drugs agentia pill of chemotherapy side effect as claimed in claim 6, it is characterized in that, steam 17 minutes in step (3) mid-food steamer.
9. alleviate the preparation method of the Chinese drugs agentia pill of chemotherapy side effect as claimed in claim 6, it is characterized in that, in step (3), the weight of Mel is 1.7 times of medicated powder weight.
10. alleviate the preparation method of the Chinese drugs agentia pill of chemotherapy side effect as claimed in claim 6, it is characterized in that, the heavy 0.3g of every ball in step (6).
CN201510008523.5A 2015-01-08 2015-01-08 Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method Pending CN104491182A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510008523.5A CN104491182A (en) 2015-01-08 2015-01-08 Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510008523.5A CN104491182A (en) 2015-01-08 2015-01-08 Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method

Publications (1)

Publication Number Publication Date
CN104491182A true CN104491182A (en) 2015-04-08

Family

ID=52932696

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510008523.5A Pending CN104491182A (en) 2015-01-08 2015-01-08 Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method

Country Status (1)

Country Link
CN (1) CN104491182A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104996526A (en) * 2015-08-06 2015-10-28 王永卿 Pastry suitable for gastric cancer patients to eat postoperatively and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1357354A (en) * 2001-05-24 2002-07-10 解建国 Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn
CN1453027A (en) * 2003-03-13 2003-11-05 红桃开集团股份有限公司 Medicine prepn for preventing and retarding side effect of chemotherapy and its prepn process
CN102327390A (en) * 2011-10-18 2012-01-25 周国生 Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills
CN103908579A (en) * 2014-04-12 2014-07-09 陈欣 Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1357354A (en) * 2001-05-24 2002-07-10 解建国 Medicine for eliminating side effect of radiotherapy and chemotherapy to treat malignant tumor and its prepn
CN1453027A (en) * 2003-03-13 2003-11-05 红桃开集团股份有限公司 Medicine prepn for preventing and retarding side effect of chemotherapy and its prepn process
CN102327390A (en) * 2011-10-18 2012-01-25 周国生 Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills
CN103908579A (en) * 2014-04-12 2014-07-09 陈欣 Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
孙安迪: "《孙安迪健康直通车.中草药篇》", 31 July 2007, 漓江出版社 *
张晓宇等: ""中药减轻化疗毒性反应研究进展"", 《辽宁中医药大学学报》 *
徐永前等: "《卵巢恶性肿瘤的中西医结合治疗对策》", 31 January 2009, 化学工业出版社 *
朱秀美等: ""国内中药防治化疗药物毒副作用的研究概况"", 《解放军药学学报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104996526A (en) * 2015-08-06 2015-10-28 王永卿 Pastry suitable for gastric cancer patients to eat postoperatively and preparation method thereof

Similar Documents

Publication Publication Date Title
CN104288651A (en) Medicine for treating postpartum hypogalactia and preparation method thereof
CN105920514A (en) Traditional Chinese medicinal composition for treating metabolic syndrome
CN103920034A (en) Traditional Chinese medicine composition for alleviating side effects of chemotherapy of cancer patient and preparation method traditional Chinese medicine composition
CN103432412B (en) Medicament for treating hyperplasia of mammary glands and preparation method thereof
CN104606580A (en) Traditional Chinese medicine preparation with synergistic effect on chemotherapy and preparation method of traditional Chinese medicine preparation traditional Chinese medicine preparation
CN103330837B (en) Traditional Chinese medicine composition for curing osteoporosis of menopausal women
CN104491529A (en) Traditional Chinese medicine granule for treating II diabetes and preparation method thereof
CN114748603A (en) Medicine-food homologous composition for preventing and treating new coronavirus pneumonia variation or compound yang and application
CN104162093A (en) Traditional Chinese medicinal preparation for treating breast cancer, and preparation method thereof
CN102614466B (en) Traditional Chinese medical preparation for treatment of lung adenocarcinoma
CN104491182A (en) Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method
WO2017101154A1 (en) Stomach-nourishing traditional chinese medicine composition and preparation method therefor
CN104840902A (en) Traditional Chinese medicine preparation for treating ovarian tumor
CN104306847A (en) Six-ingredient qi-tonifying capsule and preparation process thereof
CN103520686A (en) Medicine for curing diarrhea caused by acquired immune deficiency syndrome
CN106266334A (en) A kind of Chinese medicine composition treating fat concurrent hyperlipemia and acupuncture and drugs application
CN105194484A (en) Chinese herb preparation for preventing and treating ovarian cancer and preparation method
CN105250749A (en) Traditional Chinese medicine for treating thyroid adenoma and preparation method thereof
CN104873854A (en) Traditional Chinese medicine preparation for rteriolar nephrosclerosis and preparation method thereof
CN105748911A (en) Side reaction resisting capsule for postoperative tumor patients and preparation method thereof
CN104623451A (en) Traditional Chinese medicine composition for treating breast cancer
CN105535185A (en) Heart and spleen tonifying capsules for treating rheumatic heart diseases
CN104606537A (en) Qi-reinforcing and blood-nourishing medicated diet for improving chemotherapy-induced myocardial ischemic injury and preparation method
CN105582301A (en) Side reaction-resistant paste for postoperative patient with tumor
CN104606581A (en) Traditional Chinese medicine diet for reducing side effects of chemotherapy and preparation method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: 338000 Jiangxi Province, Xinyu City Yushui District Station Road No. 125 Xinhua 4 floor residential building 1-1001

Applicant after: Li Hong

Address before: 250000 Jianshe Road, Ji'nan, Shandong, No. 85

Applicant before: Li Hong

COR Change of bibliographic data
RJ01 Rejection of invention patent application after publication

Application publication date: 20150408

RJ01 Rejection of invention patent application after publication