CN102614466B - Traditional Chinese medical preparation for treatment of lung adenocarcinoma - Google Patents
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Abstract
The invention discloses a traditional Chinese medical preparation for treatment of lung adenocarcinoma, which is prepared based on years of clinical trials and repeated verification and complies with the theory of traditional Chinese medicine. In the formula, traditional Chinese herbs are used as raw materials, the required ingredients are separated via soaking, crushing, extraction and the like, and drugs, tablets and capsules are prepared via complexing. The formula includes 28 traditional Chinese herbs, such as lucid ganoderma, folium ilicis cornutae, barberry, lotus plumule, oldenlandia diffusa, hericium erinaceus, rhizoma sparganii, colla corii asini, pericarpium citri reticulatae, caulis lonicerae, white canary tree fruits, semen armeniacae amarae, pegaeophyton scapiflora and the like. Based on the treatment principles of removing stasis, detoxifying, replenishing qi, tonifying the lung, strengthening the spleen and improving the appetite, the whole-body mechanism can be conditioned, lesions can be removed, diseases can be treated completely, the cachexia and the quality of life can be improved, and the life can be prolonged. Studies show that the medicine has the effect of inducing apoptosis of A549 cells (human lung adenocarcinoma cells). Moreover, the medicine has the effects of no toxic or side effects, easy carrying and easy taking, and has broad prospects in clinical applications.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung.
Background technology
The adenocarcinoma of lung early symptom: adenocarcinoma of lung is what characteristic symptom not in early days, only is the common symptom of general respiratory system disease, as cough, expectorant blood, low grade fever, chest pain, unhappy etc., is easy to be ignored by patient and doctor.
Adenocarcinoma is diffused as the master with lymphatic vessel and blood vessel.Air flue is sent out and is common in bronchioloalveolar carcinoma, and its feature shows as tumor cell and sends out along air flue, forms the pathological changes of separating with main lump.Air flue is sent out the infringement that comprises homonymy and/or the same lobe of the lung of offside or the different lobes of the lung, causes the multicentricity focus, is found in bronchioloalveolar carcinoma.Peripheral adenocarcinoma can spread along pleural surface sometimes, is similar to mesothelioma.About 1/5 New Development adenocarcinoma case performance metastasis, brain, skeleton, adrenal gland and liver are modal metastasis sites.It is more rare than non-small cell carcinoma that local recurrence takes place behind the adenocarcinoma excision.Adenocarcinoma is carried out by stages according to international TNM method.
I phase and II phase pulmonary carcinoma belong to the early stage of lung cancer, and the early stage of lung cancer can allow the patient obtain long term survival by surgical operation, and medium and advanced lung cancer can make the patient obtain to be with for a long time cancer existence by surgical operation and chemicotherapy treatment.III phase nonsmall-cell lung cancer, pulmonary carcinoma have after the mediastinal lymph node metastasis N2, and simple surgical resection just dying will be with operation, adjuvant chemotherapy and radiotherapy technology combination.We are 1B-III phase nonsmall-cell lung cancer, as " systemic disease " at present.Since be systemic disease, simple outer section " cutter " excision is not all right, be with the Drug therapy of whole body, in the hope of prolonging patient's survival rate.
Summary of the invention
The present invention provides a kind of and can effectively improve the adenocarcinoma of lung patients ' life quality and improve cachexia and can prolong the Chinese medicine preparation of the treatment adenocarcinoma of lung of life cycle in order to solve the deficiencies in the prior art part.
A kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung of the present invention forms by clinic tests and repeated verification for many years configuration, meets the theory of Chinese medicine.Prescription is to be raw material with Chinese medicine, isolates required composition through immersion, pulverizing and extraction etc., makes medicament, tablet, capsule again after composite.Prescription is: 28 flavor Chinese medicines such as Ganoderma, Folium Ilicis Cornutae, Radix Berberidis, Plumula Nelumbinis, Herba Hedyotidis Diffusae, Hericium erinaceus (Bull. Ex Fr.) Pers., rhizoma sparganic, Colla Corii Asini, Pericarpium Citri Reticulatae, Caulis Lonicerae, Fructus Canarii, Semen Armeniacae Amarum, high mountain Radix Cochleariae officinalis dish; It is the Therapeutic Principle that the present invention regulates the flow of vital energy, mends stomach with dissolving blood stasis and detoxication, invigorating the lung and benefiting vital QI, spleen invigorating, from conditioning whole body health mechanism, arrive except focus, and treating both the principal and secondary aspects of a disease, thus improve cachexia, the quality of making the life better prolongs life cycle.Confirm that after deliberation this medical instrument induces the A549(human lung adenocarcinoma cell) cell
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Effect of apoptosis, and do not have toxicity, compare with Chinese medicine, portable, the advantage of easily taking has wide clinical practice scene.
A kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung is to be made by following weight portion raw material:
Ganoderma 20-30 part, Folium Ilicis Cornutae 20-30 part, Radix Berberidis 20-30 part, Plumula Nelumbinis 20-30 part, Herba Hedyotidis Diffusae 20-30 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 20-30 part, rhizoma sparganic 20-30 part, Colla Corii Asini 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Caulis Lonicerae 15-25 part, Fructus Canarii 15-25 part, Semen Armeniacae Amarum 15-25 part, high mountain Radix Cochleariae officinalis dish 15-25 part, Germinatus Phragmitis 15-25 part, Folium Eriobotryae 10-20 part, Radix Curcumae 10-20 part, Semen Platycladi 10-20 part, Fructus Citri 10-20 part, Semen Melo 10-20 part, Flos Inulae 10-20 part, Rhizoma Dioscoreae Bulbiferae 10-20 part, Radix Codonopsis 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Endothelium Corneum Gigeriae Galli 5-15 part, Olibanum 5-15 part, Flos Farfarae 5-15 part, Radix seu Herba Gei aleppici 5-15 part, Semen Coicis 5-15 part;
Preparation method:
1, it is standby by formula proportion 300 order fine powders are dried → be ground into to Ganoderma, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Codonopsis respectively;
2, will remain Chinese medicine according to formula proportion and choose only, screening is put into marmite and is added doubling dose pure water decoction 30-40 minute, extracts supernatant and is cooled to room temperature, filtrate for later use; With the slag amount of doubling pure water again, decoct and after boiling, pour filtrate into, until being boiled into the thick paste shape, dry → be crushed to 300 order fine powders after being cooled to room temperature;
3, with preparation method 1 and 2 gained fine powders, mix homogeneously incapsulates and places the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, and gets product.
Instructions of taking: take with warm water half an hour ante cibum, takes 15g every day three times at every turn, warm water delivery service, a month course for the treatment of.The avoid cold and uncooked food thing of pungent stimulation.
A kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung is to be made by following weight portion raw material:
Ganoderma 22-28 part, Folium Ilicis Cornutae 22-28 part, Radix Berberidis 22-28 part, Plumula Nelumbinis 22-28 part, Herba Hedyotidis Diffusae 22-28 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 22-28 part, rhizoma sparganic 22-28 part, Colla Corii Asini 16-24 part, Pericarpium Citri Reticulatae 16-24 part, Caulis Lonicerae 16-24 part, Fructus Canarii 16-24 part, Semen Armeniacae Amarum 16-24 part, high mountain Radix Cochleariae officinalis dish 16-24 part, Germinatus Phragmitis 16-24 part, Folium Eriobotryae 12-18 part, Radix Curcumae 12-18 part, Semen Platycladi 12-18 part, Fructus Citri 12-18 part, Semen Melo 12-18 part, Flos Inulae 12-18 part, Rhizoma Dioscoreae Bulbiferae 12-18 part, Radix Codonopsis 6-14 part, Radix Aconiti Lateralis Preparata 6-14 part, Endothelium Corneum Gigeriae Galli 6-14 part, Olibanum 6-14 part, Flos Farfarae 6-14 part, Radix seu Herba Gei aleppici 6-14 part, Semen Coicis 6-14 part.
A kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung is to be made by following weight portion raw material:
25 parts of Ganodermas, 25 parts of Folium Ilicis Cornutaes, 25 parts of Radix Berberidis, 25 parts of Plumula Nelumbiniss, 25 parts of Herba Hedyotidis Diffusaes, 25 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 25 parts of rhizoma sparganic, 20 parts in Colla Corii Asini, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Caulis Loniceraes, 20 parts of Fructus Canariis, 20 parts of Semen Armeniacae Amarums, 20 parts of high mountain Radix Cochleariae officinalis dishes, 20 parts of Germinatus Phragmitiss, 15 parts of Folium Eriobotryaes, 15 parts of Radix Curcumaes, 15 parts of Semen Platycladi, 15 parts of Fructus Citris, 15 parts of Semen Melos, 15 parts of Flos Inulaes, 15 parts of Rhizoma Dioscoreae Bulbiferaes, 10 parts of Radix Codonopsis, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Olibanums, 10 parts of Flos Farfaraees, 10 parts of Radix seu Herba Gei aleppici, 10 parts of Semen Coiciss.
The present invention relates to raw material of Chinese medicine pharmacology and the property of medicine:
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Ganoderma:
[nature and flavor] are sweet, and are flat, GUIXIN, lung, liver, kidney channel.
[curing mainly] asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.
Folium Ilicis Cornutae:
[meridian distribution of property and flavor] hardship, cold.Return liver, kidney channel.
[function cures mainly] clearing away heat and nourishing YIN, suppressing the hyperactive liver, kidney tonifying.Be used for the pulmonary tuberculosis spitting of blood, osteopyrexia and fever is had a dizzy spell; Hypertension.Cold in nature, the weakness of the spleen and stomach person needs compatibility to use.
Radix Berberidis:
[nature and flavor] hardship, cold.
[effect] heat clearing and damp drying, eliminating fire and detoxication.
[application] mainly is applicable to colorectal cancer, tumor etc.
(1) be used for colon, the rectal cancer of hyperactivity of toxic heat, disease sees that times of defecation increases, and has pus and blood mucus in the time of just, abdominal part distending pain, burning sensation of the anus etc., fit applications such as normal and Herba Patriniae, Herba Hedyotidis Diffusae, Cortex Phellodendri.
(2) be used for expectorant heat and stop up the pulmonary carcinoma of containing, disease is seen heating, chest pain, out of breath, thirsty, constipation, cough with copious phlegm etc., often cooperates and should have with Herba Taraxaci, Cortex Lycii, Folium Pyrrosiae, Herba Gnaphalii Affinis etc.
(3) be used for tumor patient through radiotherapy, after the chemotherapy leukopenia normal with the blood medicine compatibility application just of supplementing QI and nourishing YIN such as the Radix Astragali, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Radix Scrophulariae.
Plumula Nelumbinis:
[nature and flavor] hardship, cold, nontoxic;
[effect] clears away heart-fire, and reduces phlegm and internal heat hemostasis, arresting seminal emission.Control vexedly, thirsty, spit blood seminal emission, conjunctival congestion and swelling pain." book on Chinese herbal medicine is new again ": clearing away heart-fire, the suppressing the hyperactive liver fire, lung-fire falls in the purgation of spleen excess fire.The relieving restlessness of relieving summer heat, promoting the production of body fluid to quench thirst is controlled the order redness.
Herba Hedyotidis Diffusae:
[meridian distribution of property and flavor] bitter but sweet flavor, warm in nature, nontoxic.Go into the heart, liver, spleen three warps.
[function cures mainly] hyoscine has the function of heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Cure mainly diseases such as malignant tumor, appendicitis, hepatitis, bronchitis, tonsillitis, laryngitis, urinary system infection, pelvic inflammatory disease, adnexitis; Furuncle carbuncle, venom are controlled in external.The clinical multiple cancers such as gastric cancer, the esophageal carcinoma, intestinal cancer, uterus carcinoma, nasopharyngeal carcinoma that are used for the treatment of of modern Chinese medicine.
Hericium erinaceus (Bull. Ex Fr.) Pers.:
[nature and flavor] property is flat, sweet in the mouth.
[function cures mainly] sharp the five internal organs are aid digestion; Have stomach invigorating, tonify deficiency, anticancer, the effect of kidney tonifying essence; Cure mainly diseases such as anorexia and loose stool, gastric and duodenal ulcers, neurasthenia, esophageal carcinoma, gastric cancer, dizzy, sexual impotence.The edible Hericium erinaceus (Bull. Ex Fr.) Pers. of old person has the effect of nourishing and fit keeping function.
Rhizoma sparganic:
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[another name] a kind of reed mentioned in ancient books root (" the Master of Preserving Simplicity "), RHZOMA SPARGANII (" Kaibao Bencao "), red Rhizoma typhae (" Bencao Tujing "), RHIZOMA SPARGANII (" medical material compilation of data "), rhizoma scirpi (herbal for Relief of Famines), a kind of reed mentioned in ancient books grass (" word woods "), Herba Caricis Phacotae (supplement to Thousand Golden Prescriptions)
[nature and flavor] bitter in the mouth, property is flat.
[effect] removing blood stasis, circulation of qi promoting, removing food stagnancy pain relieving.
[clinical practice] is applicable to kinds of tumors, as ovarian cancer, cervical cancer, hepatocarcinoma etc.Normal and the ovarian cancer that compatibility treatment QI and blood knot is long-pending, the blood stasis stasis of blood is stagnant, cervical cancers etc. such as Rhizoma Cyperi, Rhizoma Curcumae, Radix Arnebiae (Radix Lithospermi), Fructus Fici Pumilae.The hepatocarcinoma that compatibility treatment qi depression to blood stasis, pyretic toxicity such as Herba Hedyotidis Diffusae commonly used, Pericarpium Arecae, Poria, Rhizoma Curcumae pent up.These product also are applicable to stagnation of QI and blood, abdominal part caking, hepatosplenomegaly, amenorrhea stomachache, food stagnation distending pain etc. in addition.
Colla Corii Asini:
[nature and flavor, return through] are sweet, and are flat.Return lung, liver, kidney channel.
[effect] enriches blood, and hemostasis is nourshing Yin and drynsessmoistening prescription.
[composition] donkey skin.Adjuvant: crystal sugar, yellow wine, Oleum Glycines.
[character] this product is rectangle or square block, and pitchy is glossy.Matter is hard and crisp, and section light, fragment are looked illumination and be brown translucent.Feeble QI, it is little sweet to distinguish the flavor of.
[function cures mainly] YIN nourishing of enriching blood is moisturized, hemostasis.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, dysphoria and insomnia, xeropulmonary cough.
Pericarpium Citri Reticulatae:
[meridian distribution of property and flavor] is bitter, hot, temperature; Return lung, spleen channel.
[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Caulis Lonicerae:
[meridian distribution of property and flavor] is sweet, and be cold; Attach to the lung and stomach meridians.
[effect] heat-clearing and toxic substances removing, the dispelling wind collateral dredging.Be used for the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, rheumatism pyretic arthralgia, redness and swelling of joints burning pain.
Fructus Canarii:
[nature and flavor] nature and flavor are flat, sweet in the mouth, acid.
[function cures mainly] heat clearing away, sore-throat relieving promotes the production of body fluid, detoxifcation.Be used for laryngopharynx swelling and pain, cough, excessive thirst, the poisoning of fish Eriocheir sinensis.
Semen Armeniacae Amarum:
[meridian distribution of property and flavor] hardship, temperature, poisonous lung, spleen; Return large intestine channel.
[function] Shennong's Herbal: main cough with dyspnea is thunderous, sore throat, the therapeutic method to keep the adverse QI flowing downwards, galactopoiesis incised wound, bitterly disappointed renal mass.Compendium of Material Medica: parasite killing, control all skin ulcer scabies, detumescence, all pathogenic wind Zha of the face of decaptitating bleb.
High mountain Radix Cochleariae officinalis dish:
[property of medicine] is bitter, hot, and is cold.Return lung, Liver Channel.
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[function cures mainly] heat-clearing and toxic substances removing, clearing away lung-heat to relieve cough, hemostasis, detumescence.Be used for the epidemic febrile disease heating, cough due to lung-heat, hemoptysis, wound hemorrhage, extremity edema.
Germinatus Phragmitis:
[pharmacology value] 1, help to stabilize the blood pressure blood fat reducing; 2, help to suppress cardiovascular disease; 3, help prevention and anticancer; 4, help to prevent and treat senile constipation, diuresis is recovered from fatigue; 5, help to suppress and resist viral bacterium; 6, help the health invigorating allaying tiredness.
[nutritive value] 1, homovitamin, high-cellulose, high protein 2, low sugar, low fat 3, a great number of elements that contains multiple needed by human and trace element
[health-care effect] 1, cancer-resisting effect can suppress the topoisomerase enzymatic activity, directly kill cancerous cell, and the destruction of cancer cells telomerase makes the cancerous cell can not multiple fission and wither it, activates the antioncogene adjustment signal, transfer cell growth normalization.2, to the therapeutical effect of cardiovascular disease, Germinatus Phragmitis can suppress hypertension, prevents sclerosis of blood vessels, blood fat reducing and cholesterol.3, to human immune system's influence, Germinatus Phragmitis can reduce circulating immune complex CIC content, can produce thymosin, promotes the generation of T cell, thereby improves immunologic function, regulates immunologic mechanism.4, the effect aspect defying age can reduce the lipid peroxide of human organ, the content of LOP, thereby the activity slow down aging of raising superoxide dismutase SOD.
Folium Eriobotryae:
[meridian distribution of property and flavor] bitter, be slightly cold; Return lung, the stomach warp.
[function] Folium Eriobotryae fermented product: ursolic acid 25%, ursolic acid 30%, ursolic acid 90%, ursolic acid 95%, ursolic acid 98.Folium Eriobotryae extractum has effects such as heat clearing away, lung moistening, relieving cough and resolving phlegm; Steam its leaf again and get dew, be named " Liquor Folium Eriobotryae Distillata ", heat clearing away is arranged, separate effects such as summer-heat, stomach function regulating; Be fabulous nectariferous plant again, in Mel, " Loquat Honey " is of fine quality.Leaf contains soap twenty, amygdaloside, maloic acid, oleanolic acid, tannin, vitamin B l, vitamin C etc.
Radix Curcumae:
[meridian distribution of property and flavor] is hot, bitter, and be cold; GUIXIN, lung, Liver Channel.
[effect] promoting blood circulation and stopping pain, dispersing the stagnated live-QI to relieve the stagnation of QI, removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Semen Platycladi:
[nature and flavor]: sweet, flat.GUIXIN, kidney, large intestine channel.
[function cures mainly]: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Be used for restlessness of asrhenia type and insomnia, severe palpitation, diseases such as dryness of the intestine constipation.
Fructus Citri:
[meridian distribution of property and flavor] suffering; Bitter; Acid; Temperature.Return liver; Lung; Spleen channel. ?
[effect cures mainly] breast abdominal distention is vexed; Distending pain over the hypochondrium; Cough with copious phlegm.1. supplement to the Herbal: degas, except expectorant water in mind.2. principle of Correct Diet: the therapeutic method to keep the adverse QI flowing downwards, open chest and diaphragm.3. " explaining abstruseness of the canon of materia medica ": the gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is contrary, feed, spleen invigorating.4. " herbal classic is met former ": control cough gas and stop up.5. " the medical center bun is wanted ": control gastric abscess, alleviating distention in middle-JIAO is pleasant, dissipating depression of QI.6. " book on Chinese herbal medicine is new again ": suppressing the hyperactive liver Shu Yu, the reason lung qi, the diuretic that stimulates the menstrual flow is controlled the waist beriberi.7. " it is former that book on Chinese herbal medicine is asked ": except roaring for a long time.8. " explaining abstruseness of the canon of materia medica ": the neutralization of fragrant circle property, single using
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Many with also decreasing healthy energy, going together with ginseng, art does not then have fraud yet.9. " herbal classic is met former ": the Citrus chachiensis Hort. rafter is two kinds of Fructus Citri Sarcodactylis, Fructus Citris, and nature and flavor phase class is regardless of so " detailed outline " mixes opinion.Cover Citrus chachiensis Hort. person Fructus Citri Sarcodactylis also, rafter person Fructus Citri is also held concurrently and breaks expectorant water, controls cough gas modern times and stops up, and also gets old person.Remove flesh nuclear and use it, the trouble of multitudinous anacidity receipts.10. " book on Chinese herbal medicine is just read ": fragrant circle skin, therapeutic method to keep the adverse QI flowing downwards expectorant, the fast diaphragm of alleviating distention in middle-JIAO.Though there is not the temperature of Pericarpium Citri tangerinae, belong to fragrant dry product and study carefully, the dry people of deficiency of YIN blood still works as the forbidding ear.
Semen Melo:
[meridian distribution of property and flavor] is sweet, cold.Nontoxic.
[function cures mainly] reduces phlegm, evacuation of pus, eliminating stagnation repercussive, lung heat clearing intestine moistening.Be used for poly-, the chronic bronchitis of knot in lung abscess, the abdomen, stool is smooth, cough due to lung-heat, appendicitis etc.
Flos Inulae:
[effect classification] antitussive; Expectorant; The softening the hard mass medicine; The diuretic medicine.
[meridian distribution of property and flavor] bitter in the mouth; Hot; Salty; Tepor.Return lung; Stomach; Large intestine channel.
[effect cures mainly] sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.Be used for the cough due to wind and cold, phlegm retention is held knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, epigastric oppression and rigidity.
Rhizoma Dioscoreae Bulbiferae:
[meridian distribution of property and flavor] is bitter, hot, cold; Slightly poisonous.
[function cures mainly] removing toxic substances and promoting subsidence of swelling, dissipating phlegm and resolving masses, cooling blood for hemostasis.Be used for thyromegaly, tuberculous lymphadenitis, laryngopharynx swelling and pain is spitted blood, spitting of blood, pertussis, cancerous protuberance; Furuncle is controlled in external.
Radix Codonopsis:
[meridian distribution of property and flavor] sweet in the mouth, little acid, flat.Return spleen, lung meridian.
[function cures mainly] invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Radix Aconiti Lateralis Preparata:
[nature and flavor] are hot, sweet, big heat; Poisonous; GUIXIN, kidney, spleen channel.
[function] recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, dispersing cold for relieving pain." for the recuperating depleted YANG and rescuing the patient from collapse first product medicine "
[curing mainly] is used for excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, and vomiting and diarrhoea is fainted contrary, the cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, the beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.
Endothelium Corneum Gigeriae Galli:
[meridian distribution of property and flavor] sweet in the mouth, property are put down, and go into spleen, stomach, kidney, urinary bladder channel;
[effect] strengthening the spleen to promote digestion, arresting seminal emission, eliminating mass fossil.Cure mainly: dyspepsia, eating accumulation, vomiting regurgitation, the dysentery of having loose bowels, infantile malnutrition, seminal emission, the enuresis, frequent micturition, urinary system calculus and cholelithiasis, lump in the abdomen amenorrhea, sore throat tonsillitis; The ulcerative gingivitis aphtha.
-6-
Olibanum: regulating QI, to invigorate blood circulation, pain relieving chases after poison.Antibiotic, the flatulence that restrains, dispels, promote that wound scabs, promotes cytoactive, sharp digestion, diuresis, calmness, benefit body, sharp uterus, controls wound.
Flos Farfarae:
[effect]: nourishing the lung to keep the adverse QI downward, antitussive reduces phlegm.
[curing mainly]: control cough with dyspnea and pant, sore throat.
[meridian distribution of property and flavor]: suffering, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " be sweet, nontoxic." 3. " medicine origin ": " is arduous." 4. " medicine justice ": " mildly bitter flavor is slightly hot, and property is flat."
Semen Coicis:
[nature and flavor] are cool in nature, sweet in the mouth, light.
[function cures mainly] spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.Semen Coicis can be used for treating edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.
The specific embodiment:
Embodiment 1, prescription:
20 parts of Ganodermas, 20 parts of Folium Ilicis Cornutaes, 20 parts of Radix Berberidis, 20 parts of Plumula Nelumbiniss, 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 20 parts of rhizoma sparganic, 15 parts in Colla Corii Asini, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Caulis Loniceraes, 15 parts of Fructus Canariis, 15 parts of Semen Armeniacae Amarums, 15 parts of high mountain Radix Cochleariae officinalis dishes, 15 parts of Germinatus Phragmitiss, 10 parts of Folium Eriobotryaes, 10 parts of Radix Curcumaes, 10 parts of Semen Platycladi, 10 parts of Fructus Citris, 10 parts of Semen Melos, 10 parts of Flos Inulaes, 10 parts of Rhizoma Dioscoreae Bulbiferaes, 5 parts of Radix Codonopsis, 5 parts of Radix Aconiti Lateralis Preparatas, 5 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Olibanums, 5 parts of Flos Farfaraees, 5 parts of Radix seu Herba Gei aleppici, 5 parts of Semen Coiciss;
Preparation method:
1, it is standby by formula proportion 300 order fine powders are dried → be ground into to Ganoderma, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Codonopsis respectively;
2, will remain Chinese medicine according to formula proportion and choose only, screening is put into marmite and is added doubling dose pure water decoction 30-40 minute, extracts supernatant and is cooled to room temperature, filtrate for later use; With the slag amount of doubling pure water again, decoct and after boiling, pour filtrate into, until being boiled into the thick paste shape, dry → be crushed to 300 order fine powders after being cooled to room temperature;
3, with preparation method 1 and 2 gained fine powders, mix homogeneously incapsulates and places the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, and gets product.
Instructions of taking: take with warm water half an hour ante cibum, takes 15g every day three times at every turn, warm water delivery service, a month course for the treatment of.The avoid cold and uncooked food thing of pungent stimulation.
Embodiment 2, prescription:
22 parts of Ganodermas, 22 parts of Folium Ilicis Cornutaes, 22 parts of Radix Berberidis, 22 parts of Plumula Nelumbiniss, 22 parts of Herba Hedyotidis Diffusaes, 22 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 22 parts of rhizoma sparganic, 16 parts in Colla Corii Asini, 16 parts of Pericarpium Citri Reticulataes, 16 parts of Caulis Loniceraes, 16 parts of Fructus Canariis, 16 parts of Semen Armeniacae Amarums, 16 parts of high mountain Radix Cochleariae officinalis dishes, 16 parts of Germinatus Phragmitiss, 12 parts of Folium Eriobotryaes, 12 parts of Radix Curcumaes, 12 parts of Semen Platycladi, 12 parts of Fructus Citris, 12 parts of Semen Melos, Flos Inulae
-7-
12 parts, 12 parts of Rhizoma Dioscoreae Bulbiferaes, 6 parts of Radix Codonopsis, 6 parts of Radix Aconiti Lateralis Preparatas, 6 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Olibanums, 6 parts of Flos Farfaraees, 6 parts of Radix seu Herba Gei aleppici, 6 parts of Semen Coiciss.
Preparation method is identical with embodiment 1 with usage and dosage.
Embodiment 3, prescription:
25 parts of Ganodermas, 25 parts of Folium Ilicis Cornutaes, 25 parts of Radix Berberidis, 25 parts of Plumula Nelumbiniss, 25 parts of Herba Hedyotidis Diffusaes, 25 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 25 parts of rhizoma sparganic, 20 parts in Colla Corii Asini, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Caulis Loniceraes, 20 parts of Fructus Canariis, 20 parts of Semen Armeniacae Amarums, 20 parts of high mountain Radix Cochleariae officinalis dishes, 20 parts of Germinatus Phragmitiss, 15 parts of Folium Eriobotryaes, 15 parts of Radix Curcumaes, 15 parts of Semen Platycladi, 15 parts of Fructus Citris, 15 parts of Semen Melos, 15 parts of Flos Inulaes, 15 parts of Rhizoma Dioscoreae Bulbiferaes, 10 parts of Radix Codonopsis, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Olibanums, 10 parts of Flos Farfaraees, 10 parts of Radix seu Herba Gei aleppici, 10 parts of Semen Coiciss.
Preparation method is identical with embodiment 1 with usage and dosage.
Embodiment 4, prescription:
28 parts of Ganodermas, 28 parts of Folium Ilicis Cornutaes, 28 parts of Radix Berberidis, 28 parts of Plumula Nelumbiniss, 28 parts of Herba Hedyotidis Diffusaes, 28 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 28 parts of rhizoma sparganic, 24 parts in Colla Corii Asini, 24 parts of Pericarpium Citri Reticulataes, 24 parts of Caulis Loniceraes, 24 parts of Fructus Canariis, 24 parts of Semen Armeniacae Amarums, 24 parts of high mountain Radix Cochleariae officinalis dishes, 24 parts of Germinatus Phragmitiss, 18 parts of Folium Eriobotryaes, 18 parts of Radix Curcumaes, 18 parts of Semen Platycladi, 18 parts of Fructus Citris, 18 parts of Semen Melos, 18 parts of Flos Inulaes, 18 parts of Rhizoma Dioscoreae Bulbiferaes, 14 parts of Radix Codonopsis, 14 parts of Radix Aconiti Lateralis Preparatas, 14 parts of Endothelium Corneum Gigeriae Galli, 14 parts of Olibanums, 14 parts of Flos Farfaraees, 14 parts of Radix seu Herba Gei aleppici, 14 parts of Semen Coiciss.
Preparation method is identical with embodiment 1 with usage and dosage.
Embodiment 5, prescription:
30 parts of Ganodermas, 30 parts of Folium Ilicis Cornutaes, 30 parts of Radix Berberidis, 30 parts of Plumula Nelumbiniss, 30 parts of Herba Hedyotidis Diffusaes, 30 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 30 parts of rhizoma sparganic, 25 parts in Colla Corii Asini, 25 parts of Pericarpium Citri Reticulataes, 25 parts of Caulis Loniceraes, 25 parts of Fructus Canariis, 25 parts of Semen Armeniacae Amarums, 25 parts of high mountain Radix Cochleariae officinalis dishes, 25 parts of Germinatus Phragmitiss, 20 parts of Folium Eriobotryaes, 20 parts of Radix Curcumaes, 20 parts of Semen Platycladi, 20 parts of Fructus Citris, 20 parts of Semen Melos, 20 parts of Flos Inulaes, 20 parts of Rhizoma Dioscoreae Bulbiferaes, 15 parts of Radix Codonopsis, 15 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Olibanums, 15 parts of Flos Farfaraees, 15 parts of Radix seu Herba Gei aleppici, 15 parts of Semen Coiciss;
Preparation method is identical with embodiment 1 with usage and dosage.
Quality standard of the present invention (character, discriminating, inspection, assay, pharmaceutical hygiene inspection):
Fine powder degree: 200-300 order
Moisture: do not have, need fully dry
Melting: all melt, foreign bodies such as breeze must not be arranged,
Assorted bacterium :≤1000/gram
Mycete :≤100/gram
Pathogenic bacterium: must not detect
It is full to live: must not detect.
-8-
The present invention through the animal acute toxicity test result is:
Do not see acute toxic symptoms behind continuous 3 oral administration gavages in the mice one day, the same day was not seen dead mouse in administration, and relatively, the mice each side is reported situations and do not seen notable difference for the 2nd day to the 14th day administration group and matched group (simple chemotherapy group) after the administration.Viewing duration, all mices are quick on the draw, by hair gloss, body weight gain, diet and defecation are all normal.All mices are all dissected during off-test in the 15th day, macroscopy, and each internal organs such as cardiopulmonary, liver,spleen,kidney, thymus, gastrointestinal are not seen obvious pathological changes, administration group and matched group (simple chemotherapy group) weight of mice does not have difference on the statistics (P＞0.05).Test draws that mice is oral to be gavaged thus, shows that the acute toxicity of this preparation is very little, oral safety.
Chinese medicine preparation of the present invention is fed tumor bearing nude mice, observe the influence of herb induction apoptosis of tumor cells, experimental result show matched group (simple chemotherapy group) after one month gross tumor volume obviously greater than the administration group, tissue slice shows because tumor body blood supply insufficiency, a large amount of tissue necrosiss occurs and with the part apoptosis.Can see apoptosis of tumor cells in early days in the administration group, apoptotic cell is consistent with the gross tumor volume minimum.The original position apoptosis detects the display part cell volume and dwindles, and occurs vesicle and peplos shrinkage on the cell membrane, the endochylema obvious pyknosis of nucleus that tails off, and chromatin is dense to be dyed, and what have is crescent shape limit collection, and the parts of fine cellular lysate is the fragment shape.
Induce the apoptotic experimental result of nude mice human lung adenocarcinoma A549 transplanted tumor to show, the apoptosis quantity that adds cell in this preparation Chinese drug-treated group tumor tissue is significantly higher than matched group (simple chemotherapy group) P＜0.05, and have significant difference P＜0.05 between each group of the quantity of its apoptosis, confirm that this compound preparation has the A549(of inducing human lung adenocarcinoma cell in nude mouse) apoptotic effect.
To sum up state, adopt preparation of the present invention to carry out the adenocarcinoma of lung clinical observation, establish treatment by Chinese herbs group and simple each 100 example of chemotherapy group, 1 year, 2 years, 3 years survival rates of drug treatment group are respectively 96.67%; 79.55%; 68.75%, median survival interval 26 months; 1 year, 2 years, 3 years survival rates of simple chemotherapy group are respectively 55.56%; 27.78%; 4.42%, median survival interval 15 months.
The present invention confirms that after deliberation regulating the flow of vital energy, mend stomach with dissolving blood stasis and detoxication, invigorating the lung and benefiting vital QI, spleen invigorating is the Therapeutic Principle, from conditioning whole body health mechanism, arrives except focus, and treating both the principal and secondary aspects of a disease, thus improve cachexia, the quality of making the life better prolongs life cycle.This medical instrument is induced the A549(human lung adenocarcinoma cell) apoptotic effect, and do not have toxicity, portable, the advantage of easily taking has wide clinical practice scene.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the description just illustrates principle of the present invention; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (3)
1. a Chinese medicine preparation for the treatment of adenocarcinoma of lung is characterized in that, is to be made by following weight portion raw material:
Ganoderma 20-30 part, Folium Ilicis Cornutae 20-30 part, Radix Berberidis 20-30 part, Plumula Nelumbinis 20-30 part, Herba Hedyotidis Diffusae 20-30 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 20-30 part, rhizoma sparganic 20-30 part, Colla Corii Asini 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Caulis Lonicerae 15-25 part, Fructus Canarii 15-25 part, Semen Armeniacae Amarum 15-25 part, high mountain Radix Cochleariae officinalis dish 15-25 part, Germinatus Phragmitis 15-25 part, Folium Eriobotryae 10-20 part, Radix Curcumae 10-20 part, Semen Platycladi 10-20 part, Fructus Citri 10-20 part, Semen Melo 10-20 part, Flos Inulae 10-20 part, Rhizoma Dioscoreae Bulbiferae 10-20 part, Radix Codonopsis 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Endothelium Corneum Gigeriae Galli 5-15 part, Olibanum 5-15 part, Flos Farfarae 5-15 part, Radix seu Herba Gei aleppici 5-15 part, Semen Coicis 5-15 part;
Preparation method:
⑴ it is standby that dry → be ground into 300 order fine powders by formula proportion respectively with Ganoderma, Hericium erinaceus (Bull. Ex Fr.) Pers., Radix Codonopsis;
⑵ will remain Chinese medicine according to formula proportion and choose only, and screening is put into marmite and added doubling dose pure water decoction 30-40 minute, extracts supernatant and is cooled to room temperature, filtrate for later use; With the slag amount of doubling pure water again, decoct and after boiling, pour filtrate into, until being boiled into the thick paste shape, dry → be crushed to 300 order fine powders after being cooled to room temperature;
⑶ with preparation method 1 and 2 gained fine powders, and mix homogeneously incapsulates and places the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, and gets product.
2. a kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung according to claim 1 is characterized in that, is to be made by following weight portion raw material:
Ganoderma 22-28 part, Folium Ilicis Cornutae 22-28 part, Radix Berberidis 22-28 part, Plumula Nelumbinis 22-28 part, Herba Hedyotidis Diffusae 22-28 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 22-28 part, rhizoma sparganic 22-28 part, Colla Corii Asini 16-24 part, Pericarpium Citri Reticulatae 16-24 part, Caulis Lonicerae 16-24 part, Fructus Canarii 16-24 part, Semen Armeniacae Amarum 16-24 part, high mountain Radix Cochleariae officinalis dish 16-24 part, Germinatus Phragmitis 16-24 part, Folium Eriobotryae 12-18 part, Radix Curcumae 12-18 part, Semen Platycladi 12-18 part, Fructus Citri 12-18 part, Semen Melo 12-18 part, Flos Inulae 12-18 part, Rhizoma Dioscoreae Bulbiferae 12-18 part, Radix Codonopsis 6-14 part, Radix Aconiti Lateralis Preparata 6-14 part, Endothelium Corneum Gigeriae Galli 6-14 part, Olibanum 6-14 part, Flos Farfarae 6-14 part, Radix seu Herba Gei aleppici 6-14 part, Semen Coicis 6-14 part.
3. a kind of Chinese medicine preparation for the treatment of adenocarcinoma of lung according to claim 2 is characterized in that, is to be made by following weight portion raw material:
25 parts of Ganodermas, 25 parts of Folium Ilicis Cornutaes, 25 parts of Radix Berberidis, 25 parts of Plumula Nelumbiniss, 25 parts of Herba Hedyotidis Diffusaes, 25 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 25 parts of rhizoma sparganic, 20 parts in Colla Corii Asini, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Caulis Loniceraes, 20 parts of Fructus Canariis, 20 parts of Semen Armeniacae Amarums, 20 parts of high mountain Radix Cochleariae officinalis dishes, 20 parts of Germinatus Phragmitiss, 15 parts of Folium Eriobotryaes, 15 parts of Radix Curcumaes, 15 parts of Semen Platycladi, 15 parts of Fructus Citris, 15 parts of Semen Melos, 15 parts of Flos Inulaes, 15 parts of Rhizoma Dioscoreae Bulbiferaes, 10 parts of Radix Codonopsis, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Olibanums, 10 parts of Flos Farfaraees, 10 parts of Radix seu Herba Gei aleppici, 10 parts of Semen Coiciss.
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| CN102335374A (en) * | 2011-10-09 | 2012-02-01 | 许俊斋 | Medicine special for treating lung cancer |
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