CN104491529A - Traditional Chinese medicine granule for treating II diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine granule for treating II diabetes and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses a traditional Chinese medicine granule for treating II diabetes, which comprises the following active pharmaceutical ingredients in parts by weight: 3-9 parts of medical stone, 6-12 parts of purple lythrum herb, 12-25 parts of sticky rice, 8-16 parts of radish, 6-12 parts of ophiopogon japonicus, 5-15 parts of ligusticum wallichii, 3-7 parts of celery, 7-15 parts of fructus cannabis, 10-20 parts of panax quinquefolium, 3-9 parts of fragrant peony, 9-15 parts of semen cuscutae, 5-15 parts of herba eupatorii, 3-12 parts of water chestnut, 3-8 parts of bohadschia marmorata and 10-20 parts of radix angelicae sinensis. The traditional Chinese medicine granule not only can be used for treating II diabetes, but also can play a role in regulating blood glucose, the effect of treating the II diabetes is obvious, no side effects exist, the practicability is wide, not only can the disease be well controlled, the occurrence of heart, brain, kidney, eyes, feet and other complications can be favorably prevented, but also the restoration to the damaged organism can be achieved.
Description
Technical field
The invention belongs to traditional Chinese medicine field, especially relate to a kind of Chinese medicine granules for the treatment of type ii diabetes and preparation method thereof.
Background technology
Diabetes (diabetes) are the diseases of the easy overheap of glucose in a kind of blood, domestic to its symptom so-called " hyperglycemia ", together be called " three-hypers " with hypertension, hyperlipidemia, be by the various virulence factor such as inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors act on body cause hypoinsulinism, insulin resistant etc. and cause a series of metabolism disorder syndrome such as sugar, protein, fat, water and eletrolytes.External its another name of giving is " silent killer ", and particularly " adult diabetes mellitus ", it is high especially that the middle age of more than 40 years old catches rate.
Diabetes divide the diabetes of type i diabetes, type ii diabetes, gestational diabetes and other specific types.1. I type patients with type Ⅰ DM is a kind of autoimmune disease.Autoimmune disease is because the immune system of health is attacked self making.The pancreas beta cell of immune system to self excreting insulin of diabetics is made and is attacked and kill them, and result pancreas can not secrete enough insulins.Because insulin secretion lacks, patient need rely on exogenous insulin and supplement to sustain life.
2. type ii diabetes is Adult Onset's patients with type Ⅰ DM, how the sequela of 35 ~ 40 years old, accounts for diabetics more than 90%.The ability producing insulin in patient body not completely loses, and in some patient bodies, insulin even produces too much, but the action effect of insulin is had a greatly reduced quality, and the insulin therefore in patient body is a kind of shortage relatively.3. gestational diabetes refers to the diabetes that women suffers from phenolics.Can there are diabetes at phenolics in the women of clinical data display nearly 2 ~ 3%, patient's diabetes after gestation disappear automatically.Gestational diabetes more easily occurs in obesity and lying-in woman advanced in years.Type ii diabetes may be developed into after having the gestational diabetes women of 30% nearly.The performances such as wherein type ii diabetes has very strong heritability and environmental factors, and in significant heterogeneous, and polyuria, polydipsia, polyphagia can appear in its model case, become thin, i.e. " three-many-one-little " symptom, namely so-called type ii diabetes.
In the prescription of existing treatment type ii diabetes, Authorization Notice No. CN 102772630 B(application number 201210284045.7) patent discloses a kind of medicine for the treatment of II patients with type Ⅰ DM, be crude drug mix homogeneously by the Chinese medicine of following portions by weight, be ground into 100-120 object medicated powder, add excipient, sterilization prepares tablet according to a conventional method: Radix Rehmanniae 10-14, Radix Scrophulariae 10-14, Fructus Ligustri Lucidi 10-14, Herba Epimedii 10-14, Gecko 1-4, Semen Cuscutae 3-5, Rhizoma Coptidis 3-5, Radix Panacis Quinquefolii 1-4, Ramulus Euonymi 10-14, Radix Arnebiae (Radix Lithospermi) 1-4, Radix Notoginseng 1-4, Rhizoma Polygoni Cuspidati 10-14, Fructus Gardeniae 3-5, Spica Prunellae 10-14, Radix Astragali 10-14, Rhizoma Atractylodis 10-14, Rhizoma Atractylodis Macrocephalae 10-14, Semen Plantaginis 10-14.Authorization Notice No. CN 103110815 B(application number 201310038151.1) patent discloses a kind of preparation method for the treatment of the Chinese medicine composition of type Ⅱdiabetes mellitus, it is characterized in that, take off the crude drug stating weight proportion: Radix Astragali 10-30 part, Radix Codonopsis 9-30 part, Radix Rehmanniae 12-30 part, Rhizoma Dioscoreae 15-30 part, Rhizoma Polygonati Odorati 6-12 part, Fructus Lycii 5-15 part, Radix Asparagi 10-20 part, Radix Scrophulariae 10-15 part, Fructus Ligustri Lucidi 6-15 part, Radix Puerariae 7-15 part, Fructus Momordicae charantiae powder 20-50 part, Radix Linderae 3-9 part, Fructus Mori 9-15 part, Cortex Lycii 15-30 part
As can be seen here, Chinese medicine achieves good curative effect in treatment type ii diabetes, but its preparation method all more complicated, and great majority are decoctions, and as everyone knows, decoction is inconvenient to carry, and pure Chinese medicine decoction hardship very, are not easy to swallow.
Summary of the invention
For the deficiency of existing treatment type ii diabetes method, an object of the present invention is to provide a kind of Chinese medicine granules for the treatment of type ii diabetes, taking in this medicine therapeutic process, instant effect, and have no side effect, while improving polydipsia, polyuria symptom, can also regulate blood glucose, be a kind of ideal Chinese medicine granule for the treatment of type ii diabetes.
Another object of the present invention is just to provide the preparation method of the Chinese medicine granules of above-mentioned treatment type ii diabetes.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine granules for type ii diabetes, each crude drug is as follows, is weight portion: Maifanitum 3-9, Herba Lythri Salicariae 6-12, Oryza glutinosa 12-25, Radix Raphani 8-16, Radix Ophiopogonis 6-12, Rhizoma Chuanxiong 5-15, Herba Apii graveolentis 3-7, Fructus Cannabis 7-15, Radix Panacis Quinquefolii 10-20, Radix Paeoniae 3-9, Semen Cuscutae 9-15, Herba Eupatorii 5-15, Corm Eleocharitis 3-12, Bai Nican 3-8, Radix Angelicae Sinensis 10-20.
Treat a Chinese medicine granules for type ii diabetes, preferred scheme, each crude drug is as follows, be weight portion: Maifanitum 5-7, Herba Lythri Salicariae 8-10, Oryza glutinosa 16-21, Radix Raphani 12-14, Radix Ophiopogonis 8-10, Rhizoma Chuanxiong 8-13, Herba Apii graveolentis 4-6, Fructus Cannabis 10-12, Radix Panacis Quinquefolii 13-18, Radix Paeoniae 5-7, Semen Cuscutae 11-13, Herba Eupatorii 8-13, Corm Eleocharitis 5-10, Bai Nican 4-6, Radix Angelicae Sinensis 13-18.
Treat a Chinese medicine granules for type ii diabetes, better preferred scheme, each crude drug is as follows, be weight portion: Maifanitum 6, Herba Lythri Salicariae 9, Oryza glutinosa 18, Radix Raphani 13, Radix Ophiopogonis 9, Rhizoma Chuanxiong 10, Herba Apii graveolentis 5, Fructus Cannabis 11, Radix Panacis Quinquefolii 15, Radix Paeoniae 6, Semen Cuscutae 12, Herba Eupatorii 11, Corm Eleocharitis 8, Bai Nican 5, Radix Angelicae Sinensis 15.
Treat a preparation method for the Chinese medicine granules of type ii diabetes, step is as follows:
1. Maifanitum is placed in the hot water of 80-100 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 10-30 minute (preferably 20 minutes), taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 1-5 minute, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts in the hot pot that dryouies and fries 3-8 minute with low baking temperature, take out, and when placing room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 10-30 minute slowly, dries in the air coolly to grind to form smalls, crosses 80-120 mesh sieve (preferably 100 mesh sieves);
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 1-3 centimetre after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 1-3 time, add Oryza glutinosa weight 8-12 water doubly, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 4-8 minute, be blended into cold water, turn slow fire boiling 20-40 minute, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste at 50-70 DEG C of dry 10-18 hour, make granule.
The preparation method of above-mentioned Chinese medicine granules, step 1. Maifanitum is placed in the hot water (preferred Maifanitum is placed in the hot water of 90 DEG C) of 85-95 DEG C.
The preparation method of above-mentioned Chinese medicine granules, step 2. high temperature sterilization 2-4 minute (preferred high temperature sterilization 3 minutes).
The preparation method of above-mentioned Chinese medicine granules, step 3. little fire is dried 15-25 minute (preferred little fire dries 20 minutes slowly) slowly.
The preparation method of above-mentioned Chinese medicine granules, 5. step adds Oryza glutinosa weight 9-11 water (preferably adding the water of Oryza glutinosa weight 10 times) doubly.
The preparation method of above-mentioned Chinese medicine granules, step after 5. big fire boils 5-7 minute, is blended into cold water, turns slow fire boiling 25-35 minute (preferred big fire boil 6 minutes after, be blended into cold water, turn slow fire boiling 30 minutes).
The preparation method of above-mentioned Chinese medicine granules, step 6. thick paste, at 55-65 DEG C of dry 12-16 hour, makes granule (preferred thick paste, 60 DEG C of dryings 14 hours, makes granule).
The present invention is to the Be very effective of type ii diabetes, and be the therapeutic effect making the present invention reach best, every day 3 times, take respectively at half an hour after breakfast, lunch and dinner, each 2g, boiled water is taken after mixing it with water, and within 10 days, is a course for the treatment of.
The pharmacological effect of each crude drug is respectively:
Maifanitum: base is former: be Acid-intermediate igneous rock rocks beschtauite.Composition: Maifanitum main component has silicon dioxide, aluminium oxide, ferrum oxide, ferrous oxide, magnesium oxide, calcium oxide, sodium oxide, potassium oxide, titanium dioxide, phosphorus pentoxide, manganese oxide, carbon dioxide, and the trace element such as fluorine, sulfur, strontium, barium, copper, zinc.The property of medicine: " detailed outline ": " sweet, temperature, nontoxic." function cures mainly: removing toxic substances and promoting granulation, damp eliminating spleen invigorating.Cure mainly carbuncle carbuncle on the back, acne, eczema, beriberi, miliaria, finger is chapped, chloasma, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.Generally make health product.
Herba Lythri Salicariae: have another name called Purple Loosestrife, Herba pteridis vittatae, to tooth grass, be the herb of Lythraceae Lythrum plant Herba Lythri Salicariae.The property of medicine: bitter in the mouth, cold in nature.Composition: herb contains Salicarin, choline, gallotannin, orientin, chlorogenic acid etc.Find according to modern pharmacological research, this medical instrument has blood sugar lowering, antibacterial, heat-clearing and toxic substances removing, anastaltic effect, and for hyperglycemia, spit blood, epistaxis, has loose bowels, and skin infection festers.
Oryza glutinosa: base is former: be the kernel that shells of grass family oryza plant Oryza sativa L. var. glutinosa Matsum..The property of medicine: sweet, temperature.Return spleen, stomach, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, invigorating the spleen to arrest diarrhea, reducing urination, arresting sweating, removing toxic substances.Cure mainly Deficiency and coldness of spleen and stomach to have loose bowels, cholera is told inverse, frequent micturition of quenching one's thirst, spontaneous perspiration, variola, hemorrhoid.
Radix Raphani: base is former: be fresh of Cruciferae Radix Raphani platymiscium Radix Raphani.Composition: root contains glycoside glucosinolate, glucose raphanin, raphanusin.Phenolic acids: P-coumaric acid, caffeic acid, ferulic acid, phenylpyruvic acid, gentisic acid etc.The property of medicine: acrid, sweet, cool; Ripe person is sweet, flat.Return spleen, stomach, lung, large intestine channel.Function cures mainly: help digestion, and the therapeutic method to keep the adverse QI flowing downwards is reduced phlegm, hemostasis.Cure mainly dyspepsia, food stagnation distension, acid regurgitation, regurgitation of food from the stomach, tells food, and hemorrhoidal hamorrhage is had loose bowels, dysentery, constipation, phlegm-heat cough, discomfort in the throat, hemoptysis, and spit blood, epistaxis, has blood in stool, and quenches one's thirst, and drenches worm.Outer treatment skin ulcer abscess, damage congestive edema, scalds and chilblain.
Radix Ophiopogonis: Radix Ophiopogonis (Ophiopogon japonicus) has another name called dwarf lilyturf, book band grass, Radix Ophiopogonis, Radix Ophiopogonis is Liliaceae Ophiopogon perennial evergreen herbaceous plant.Fibrous root is more sturdy, and the top of root or middle part are often expanded becomes fusiform meat fritter.Be used as medicine with tuber.Sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp., micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.[function with cure mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Herba Apii graveolentis: Herba Apii graveolentis, belongs to samphire.Have Herba Oenanthes Javanicae, Herba Apii graveolentis, Herba Apii graveolentis three kinds, function is close, and medicinal is good with Herba Apii graveolentis.Herba Apii graveolentis fragrance is denseer, claims " medicine celery ".But with Herba Coriandri is not a kind, Herba Apii graveolentis rich in proteins, carbohydrate, carotene, vitamin B group, calcium, phosphorus, ferrum, sodium etc., simultaneously, have and have calming liver and clearing heat, expelling wind and removing dampness, relieving restlessness is subsided a swelling, cooling blood for hemostasis, removing toxic substances lung qi dispersing, stomach invigorating profit blood, bowel relieving is convenient, nourishing the lung to arrest cough, reduce blood pressure, effect of brain-strengthening calmness.Apiin also containing active ingredient in base of leaf, majudin and volatile oil, have blood pressure lowering, blood fat reducing, the atherosclerotic effect of control; Also certain auxiliary dietary function is had to neurasthenia, menoxenia, gout, anti-muscle spasm; It can also promote gastric secretion, increases appetite.Particularly old people, easily suffers from because body movement amount is little, dietary amount is few, amount of drinking water is not enough and being hard and dry, and often has some Herba Apii graveolentis and can be beneficial to defecation by stimulating gastrointestinal wriggling.
Fructus Cannabis: base is former: be the kernel of Moraceae Cannabis plant Fructus Cannabis.Composition: seed contains trigonelline, L-dextrorotation isoleucine Glycocoll betaine.Seed fatty acids and lipid: stearic acid, arachidic acid, lignoceric acid, Palmic acid, palmitoleic acid etc.The property of medicine: sweet, flat.Return spleen, stomach, large intestine channel.Function cures mainly: moisturize laxation, and diuretic is invigorated blood circulation.Cure mainly dryness of the intestine constipation, migratory arthralgia, quench one's thirst, edema due to wind pathogen, beriberi, pyretic stranguria, dysentery, menoxenia, skin ulcer tinea, erysipelas.
Radix Panacis Quinquefolii: Radix Panacis Quinquefolii is Araliaceae Panax perennial grass wood plant, another name Radix Panacis Quinquefolii, Radix Panacis Quinquefolii, Western Radix Ginseng, cool in nature, sweet in the mouth, micro-hardship.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, and dry mouth larynx is done.Consumption 3 ~ 6g.Lung benefiting is cloudy, clear asthenic fire, promoting the production of body fluid to quench thirst.Control deficiency of the lung chronic cough, lose blood, dry throat and mouth, deficiency-heat is tired of tired.
Radix Paeoniae: the fresh and crisp succulence of root of Radix Paeoniae, can hyoscine (be used as medicine time-division Radix Paeoniae Rubra, the Radix Paeoniae Alba two kinds).According to analysis, Peony Root contains paeoniflorin and benzoic acid, and purposes is different because of kind.The traditional Chinese medical science is thought: the Radix Paeoniae Alba in Chinese medicine mainly refers to the root of Radix Paeoniae, and it has spasmolytic, eases pain, the effect of stimulating the menstrual flow.Effective to diseases such as the stomachache of women, stomach spasm, dizzy, gout, diuresis.
Herba Eupatorii: base is former: be the aerial parts of Compositae feverwort Herba Eupatorii.Composition: 1. Herba Eupatorii herb is containing volatile oil: to P-cymene, neryl acetate, thymol methyl ether.Taraxasterol is contained, taraxasterylacetate, taraxasterol cetylate etc. in flower and leaf.2. Taiwan Herba Eupatorii is containing sesquiterpenoids composition: eupatolide, Herba Euptatorii formosani lactone, 4-hydroxyl-2-methylol-2-butylene acyl Herba Euptatorii formosani lactone.The property of medicine: pungent, flat.Return spleen, stomach warp.Function cures mainly: expelling summer-heat and damp, be amusing and in.Cure mainly heat-damp in summer or hygropyrexia from the beginning of, generate heat nose heave, abdominal distention uncomfortable in chest, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, sweet greasy in mouth, quenches one's thirst.
Corm Eleocharitis: another name Horse hoof, black taro, Di Li.Flavor efficacy: sweet, cold.Function heat clearing away, reduce phlegm, removing food stagnancy, change wart.Be applicable to that epidemic febrile disease is quenched one's thirst, jaundice, pyretic stranguria, mass in the abdomen, conjunctival congestion, laryngopharynx swelling and pain, wart etc.Prevention acute infectious disease, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, diuresis relieving constipation is eliminated the phlegm, help digestion de-swelling, conditioning hemorrhoid or dysentery is had blood in stool, woman uterine bleeding, lung-dryness syndrome due to deficiency of YIN, phlegm-heat cough, discomfort in the throat, mass in the abdomen are gathered, conjunctival congestion is hidden from view, auxiliary effect such as to bring down a fever.In addition, Corm Eleocharitis contains a kind of antiviral substance can suppress epidemic encephalitis, influenza virus, can be used for the propagation preventing epidemic encephalitis and influenza.
Bai Nican: for Holothuriidae Bu Shi joins the entirety belonging to animal Bohadschia argus Jaeger and figure stricture of vagina Bai Nican (removing internal organs).The property of medicine: taste is micro-sweet, warm in nature.Composition: main containing triterpene glycosides, also has the elements such as sodium, potassium, calcium, phosphorus, magnesium, ferrum, zinc.Find according to modern pharmacological research, this medical instrument has effect of sterilization, nourishing YIN to lower pathogenic fire, the kidney invigorating, for diseases such as edema.
Semen Cuscutae: base is former: be the herb of Convolvulaceae Hellweed Semen Cuscutae.Composition: Semen Cuscutae is containing alkaloid, anthraquinone, coumarin, flavone, glycoside, sterol, tannic acid, saccharide etc.Flavonoid has: Quercetin, astragalin, hyperin; Sterols has: cholesterol, campesterol, cupreol, stigmasterol, β-Amyrin.Also trace element is contained as strontium, molybdenum, calcium, magnesium, ferrum, manganese, zinc, copper etc. and several amino acids (free amino acid in seed and the total amino acids after being hydrolyzed are 5.3%, and wherein the content of essential amino acids accounts for 42.8%).The property of medicine: micro-pungent, sweet, flat, nontoxic.Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Rhizoma Chuanxiong: activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Radix Angelicae Sinensis: sweet, pungent, warm, enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Chinese medicine granules of the present invention can not only treat type ii diabetes shape, the effect regulating blood glucose can also be played, treatment type ii diabetes Be very effective, have no side effect, practicality is wide, the state of an illness not only can be made to be well controlled, to be conducive to the generation preventing many-sided complication such as the heart, brain, kidney, eye, foot, and repair can be played to the body of damage.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1: a kind of Chinese medicine granules for the treatment of type ii diabetes, each crude drug is as follows, is weight portion (getting 10g for every part): Maifanitum 3, Herba Lythri Salicariae 6, Oryza glutinosa 12, Radix Raphani 8, Radix Ophiopogonis 6, Rhizoma Chuanxiong 5, Herba Apii graveolentis 3, Fructus Cannabis 7, Radix Panacis Quinquefolii 10, Radix Paeoniae 3, Semen Cuscutae 9, Herba Eupatorii 5, Corm Eleocharitis 3, Bai Nican 3, Radix Angelicae Sinensis 10.
Treat a Chinese medicine granules for type ii diabetes, preparation process is as follows:
1. Maifanitum is placed in the hot water of 80 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 10 minutes, taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 1 minute, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts interior the low baking temperature of hot pot dryouied and fry 3 minutes, takes out, and during placement room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 10 minutes slowly, dries in the air coolly to grind to form smalls, crosses 80 mesh sieves;
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 1 centimetre after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 1 time, add the water of Oryza glutinosa weight 8 times, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 4 minutes, be blended into cold water, turn slow fire boiling 20 minutes, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste 50 DEG C of dryings 10 hours, make granule.
model case one:king XX, female, 45 years old, people from Liaocheng of Shandong Province.Symptom: patient suffers from type ii diabetes, the symptom of have polydipsia, polyuria, polyphagia, becoming thin, has a meal a lot every day, and health although do not have pain, but made the huge mental pressure of patient's back not as one day in one day.Drinking YUQUAN WAN during one's sickness, but effect is not fine always, in nearest half a year, eats YUQUAN WAN and does not substantially have onset, malaise symptoms aggravates, and household asks about everywhere, learns Chinese medicine granules of the present invention always.
Take embodiment 1 gained Chinese medicine granules, take 5 days, sensation appetite reduces to some extent, polyuria, and polydipsia symptom alleviates; Take 15 days, appetite recovers normal substantially, and polydipsia symptom is alleviated further; Take 15 days, polydipsia transference cure, appetite recovers normal, and patient has laid down psychological burden, and the mental status of people might as well be a lot.
embodiment 2: a kind of Chinese medicine granules for the treatment of type ii diabetes, each crude drug is as follows, is weight portion (getting 10g for every part): Maifanitum 9, Herba Lythri Salicariae 12, Oryza glutinosa 25, Radix Raphani 16, Radix Ophiopogonis 12, Rhizoma Chuanxiong 15, Herba Apii graveolentis 7, Fructus Cannabis 15, Radix Panacis Quinquefolii 20, Radix Paeoniae 9, Semen Cuscutae 15, Herba Eupatorii 15, Corm Eleocharitis 12, Bai Nican 8, Radix Angelicae Sinensis 20.
Treat a Chinese medicine granules for type ii diabetes, preparation process is as follows:
1. Maifanitum is placed in the hot water of 100 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 30 minutes, taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 5 minutes, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts interior the low baking temperature of hot pot dryouied and fry 8 minutes, takes out, and during placement room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 30 minutes slowly, dries in the air coolly to grind to form smalls, crosses 120 mesh sieves;
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 1-3 centimetre after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 3 times, add the water of Oryza glutinosa weight 12 times, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 8 minutes, be blended into cold water, turn slow fire boiling 40 minutes, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste 70 DEG C of dryings 18 hours, make granule.
model case two:zhu XX, man, 58 years old, Donga County, Liaocheng of Shandong Province.Symptom: patient suffers from type ii diabetes, eats four meals every day, still often has hunger sensation, although have an enormous appetite, but lean body mass, drink large water gaging every day and can not alleviate thirsty symptom.On ordinary days brew diabetic tea, effect is undesirable, removes examination in hospital, and doctor advised takes gained Chinese medicine granules of the present invention.
Take embodiment 2 gained Chinese medicine granules, take 5 days, thirsty symptom alleviates; Take 15 days, blood glucose is steady, and patient has stopped the blood sugar lowering Western medicine always taken; Take 20 days, thirsty symptom disappears substantially, and patient's appetite also recovers normal, and body weight also increases to some extent; Take 40 days, take period, patient blood glucose is held stationary always, still adheres to so far taking for keeping blood glucose.
embodiment 3:treat a Chinese medicine granules for type ii diabetes, each crude drug is as follows, is weight portion (getting 10g for every part): Maifanitum 5, Herba Lythri Salicariae 8, Oryza glutinosa 16, Radix Raphani 12, Radix Ophiopogonis 8, Rhizoma Chuanxiong 8, Herba Apii graveolentis 4, Fructus Cannabis 10, Radix Panacis Quinquefolii 13, Radix Paeoniae 5, Semen Cuscutae 11, Herba Eupatorii 8, Corm Eleocharitis 5, Bai Nican 4, Radix Angelicae Sinensis 13.
Treat a Chinese medicine granules for type ii diabetes, preparation process is as follows:
1. Maifanitum is placed in the hot water of 85 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 15 minutes, taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 2 minutes, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts interior the low baking temperature of hot pot dryouied and fry 5 minutes, takes out, and during placement room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 15 minutes slowly, dries in the air coolly to grind to form smalls, crosses 90 mesh sieves;
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 1.5 centimetres after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 1 time, add the water of Oryza glutinosa weight 9 times, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 5 minutes, be blended into cold water, turn slow fire boiling 25 minutes, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste 55 DEG C of dryings 12 hours, make granule.
embodiment 4:treat a Chinese medicine granules for type ii diabetes, each crude drug is as follows, is weight portion (getting 10g for every part): Maifanitum 7, Herba Lythri Salicariae 10, Oryza glutinosa 21, Radix Raphani 14, Radix Ophiopogonis 10, Rhizoma Chuanxiong 13, Herba Apii graveolentis 6, Fructus Cannabis 12, Radix Panacis Quinquefolii 18, Radix Paeoniae 7, Semen Cuscutae 13, Herba Eupatorii 13, Corm Eleocharitis 10, Bai Nican 6, Radix Angelicae Sinensis 18.
Treat a Chinese medicine granules for type ii diabetes, preparation process is as follows:
1. Maifanitum is placed in the hot water of 95 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 25 minutes, taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 4 minutes, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts interior the low baking temperature of hot pot dryouied and fry 7 minutes, takes out, and during placement room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 25 minutes slowly, dries in the air coolly to grind to form smalls, crosses 110 mesh sieves;
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 2.5 centimetres after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 3 times, add the water of Oryza glutinosa weight 11 times, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 7 minutes, be blended into cold water, turn slow fire boiling 35 minutes, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste 65 DEG C of dryings 16 hours, make granule.
model case three:poplar XX, man, 50 years old, people from Jiyang County, Jinan City, Shandong Province.Symptom: patient suffers from II type glycosuria, often feel thirsty, drink a large amount of water every day and still can not alleviate thirsty symptom, number of times of going to toilet every day reaches 20 times, although there is no slight illness, life is brought inconvenience, take other drug and be all of no curative effect, household is very worried, finds gained Chinese medicine granules of the present invention online being not intended to.
Take embodiment 4 gained Chinese medicine granules, take 3 days, thirsty symptom is alleviated to some extent, no longer occurs the sensation of very dry cough after drinking water in a large number; Take 8 days, blood glucose declines, and every day drinks discharge reduction, and number of times of going to toilet decreases many, substantially remains on every day 10 times; Take 30 days, thirsty transference cure, total urination time recovers normal, and blood glucose can held stationary.Have no side effect during taking appearance.
embodiment 5: a kind of Chinese medicine granules for the treatment of type ii diabetes, each crude drug is as follows, is weight portion (getting 10g for every part): Maifanitum 6, Herba Lythri Salicariae 9, Oryza glutinosa 18, Radix Raphani 13, Radix Ophiopogonis 9, Rhizoma Chuanxiong 10, Herba Apii graveolentis 5, Fructus Cannabis 11, Radix Panacis Quinquefolii 15, Radix Paeoniae 6, Semen Cuscutae 12, Herba Eupatorii 11, Corm Eleocharitis 8, Bai Nican 5, Radix Angelicae Sinensis 15.
Treat a Chinese medicine granules for type ii diabetes, preparation process is as follows:
1. Maifanitum is placed in the hot water of 90 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 20 minutes, taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 3 minutes, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts interior the low baking temperature of hot pot dryouied and fry 6 minutes, takes out, and during placement room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 20 minutes slowly, dries in the air coolly to grind to form smalls, crosses 100 mesh sieves;
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 2 centimetres after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 2 times, add the water of Oryza glutinosa weight 10 times, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 6 minutes, be blended into cold water, turn slow fire boiling 30 minutes, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste 60 DEG C of dryings 14 hours, make granule.
test example 1the clinical practice of the Chinese medicine granules of embodiment 5 gained treatment type ii diabetes: screen 200 routine patients in 4 hospitals, wherein women 100 example, male 100 example.Before test 1 week, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes products obtained therefrom of the present invention, and matched group takes the medicine (as conventional medicines such as YUQUAN WAN) of other treatment type ii diabetes.Curative effect situation criterion: cure: after taking this product, malaise symptoms disappears completely; Effective: after taking this product, malaise symptoms alleviates or partial disappearance; Invalid: after taking this product, malaise symptoms is unchanged or recur.Total effectively comprising cures with effective, and result is as shown in table 1.
The checking of embodiment 5 products obtained therefrom therapeutic effect taken by table 1
Therapeutic effect: as apparent from table 1 can, take healing 88 example (88%) of experimental group of the Chinese medicine granules of the embodiment of the present invention 3 gained treatment type ii diabetes, effective 11 examples (11%), invalid 1 example (1%), total effective rate 99%.And the cure rate of matched group only reaches 45%, inefficiency is but up to 32%, and the experimental group taking the Chinese medicine granules of gained of the present invention treatment type ii diabetes is obviously better than taking the matched group of other drug.Chinese medicine granules of the present invention can not only treat the diabetes caused by diabetes, can also regulate blood glucose in the lump, alleviates the body burden of patient, is a kind of ideal Chinese medicine granule for the treatment of type ii diabetes.
Claims (10)
1. treat a Chinese medicine granules for type ii diabetes, it is characterized in that: each crude drug is as follows, is weight portion: Maifanitum 3-9, Herba Lythri Salicariae 6-12, Oryza glutinosa 12-25, Radix Raphani 8-16, Radix Ophiopogonis 6-12, Rhizoma Chuanxiong 5-15, Herba Apii graveolentis 3-7, Fructus Cannabis 7-15, Radix Panacis Quinquefolii 10-20, Radix Paeoniae 3-9, Semen Cuscutae 9-15, Herba Eupatorii 5-15, Corm Eleocharitis 3-12, Bai Nican 3-8, Radix Angelicae Sinensis 10-20.
2. the Chinese medicine granules for the treatment of type ii diabetes according to claim 1, is characterized in that: each crude drug is as follows, is weight portion: Maifanitum 5-7, Herba Lythri Salicariae 8-10, Oryza glutinosa 16-21, Radix Raphani 12-14, Radix Ophiopogonis 8-10, Rhizoma Chuanxiong 8-13, Herba Apii graveolentis 4-6, Fructus Cannabis 10-12, Radix Panacis Quinquefolii 13-18, Radix Paeoniae 5-7, Semen Cuscutae 11-13, Herba Eupatorii 8-13, Corm Eleocharitis 5-10, Bai Nican 4-6, Radix Angelicae Sinensis 13-18.
3. the Chinese medicine granules for the treatment of type ii diabetes according to claim 1, is characterized in that: each crude drug is as follows, is weight portion: Maifanitum 6, Herba Lythri Salicariae 9, Oryza glutinosa 18, Radix Raphani 13, Radix Ophiopogonis 9, Rhizoma Chuanxiong 10, Herba Apii graveolentis 5, Fructus Cannabis 11, Radix Panacis Quinquefolii 15, Radix Paeoniae 6, Semen Cuscutae 12, Herba Eupatorii 11, Corm Eleocharitis 8, Bai Nican 5, Radix Angelicae Sinensis 15.
4. the preparation method of the Chinese medicine granules of the treatment type ii diabetes according to any one of claim 1-3, is characterized in that: step is as follows:
1. Maifanitum is placed in the hot water of 80-100 DEG C, when water temperature is cooled to room temperature, adds Sal, after Sal melts completely, soak 10-30 minute (preferably 20 minutes), taking-up is placed on clean gauze stand-by;
2. get Radix Angelicae Sinensis and Rhizoma Chuanxiong to clean, drain away the water, high temperature sterilization 1-5 minute, section, uses rice vinegar uniform spraying, slightly vexed 10 minutes, puts in the hot pot that dryouies and fries 3-8 minute with low baking temperature, take out, and when placing room temperature, it is stand-by to grind to form smalls;
3. be placed on tile by Herba Lythri Salicariae, Radix Ophiopogonis, Fructus Cannabis, Radix Panacis Quinquefolii, Radix Paeoniae, Semen Cuscutae, Herba Eupatorii, Corm Eleocharitis and Bai Nican, little fire dries 10-30 minute slowly, dries in the air coolly to grind to form smalls, crosses 80-120 mesh sieve (preferably 100 mesh sieves);
4. cleaned by Radix Raphani, the block being cut into coin-size and the Herba Apii graveolentis being cut into long 1-3 centimetre after cleaning mix stand-by;
5. Oryza glutinosa is eluriated 1-3 time, add Oryza glutinosa weight 8-12 water doubly, soak after 1 hour and add step 1. gained Maifanitum, big fire adds step 4. gains after boiling, after big fire boils 4-8 minute, be blended into cold water, turn slow fire boiling 20-40 minute, slowly stir with ferrum spoon, to be mixed when becoming thick liquid to Radix Raphani and Herba Apii graveolentis, Maifanitum is taken out, adds step 2. and 3. gained smalls, fully stir into thick paste;
6. by step 5. gained thick paste at 50-70 DEG C of dry 10-18 hour, make granule.
5. the preparation method of Chinese medicine granules according to claim 4, is characterized in that: step 1. Maifanitum is placed in the hot water (preferred Maifanitum is placed in the hot water of 90 DEG C) of 85-95 DEG C.
6. the preparation method of Chinese medicine granules according to claim 4, is characterized in that: step 2. high temperature sterilization 2-4 minute (preferred high temperature sterilization 3 minutes).
7. the preparation method of Chinese medicine granules according to claim 4, is characterized in that: step 3. little fire is dried 15-25 minute (preferred little fire dries 20 minutes slowly) slowly.
8. the preparation method of Chinese medicine granules according to claim 4, is characterized in that: 5. step adds Oryza glutinosa weight 9-11 water (preferably adding the water of Oryza glutinosa weight 10 times) doubly.
9. the preparation method of Chinese medicine granules according to claim 4, is characterized in that: step after 5. big fire boils 5-7 minute, is blended into cold water, turns slow fire boiling 25-35 minute (preferred big fire boil 6 minutes after, be blended into cold water, turn slow fire boiling 30 minutes).
10. the preparation method of Chinese medicine granules according to claim 4, is characterized in that: step 6. thick paste, at 55-65 DEG C of dry 12-16 hour, makes granule (preferred thick paste, 60 DEG C of dryings 14 hours, makes granule).
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| CN105748981A (en) * | 2016-02-29 | 2016-07-13 | 鹿宁 | Combined medicine for treating diabetic nephropathy and preparation method thereof |
| CN105878796A (en) * | 2015-08-17 | 2016-08-24 | 张斌 | Vinegar beverage capable of treating type-II diabetes mellitus complicated with dyslipidemia and preparation method of vinegar beverage |
| CN106822652A (en) * | 2017-03-24 | 2017-06-13 | 成都海青生物科技有限公司 | It is a kind of to treat decoction medicine of diabetes and preparation method thereof |
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Application publication date: 20150408 |