CN104784587A - Traditional Chinese medicine composition for treating endocrine disorder type infertility and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating endocrine disorder type infertility and preparation method thereof Download PDF

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CN104784587A
CN104784587A CN201510231638.0A CN201510231638A CN104784587A CN 104784587 A CN104784587 A CN 104784587A CN 201510231638 A CN201510231638 A CN 201510231638A CN 104784587 A CN104784587 A CN 104784587A
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宋佳伦
郭艳艳
李召廷
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宋佳伦
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Abstract

The invention discloses a traditional Chinese medicine composition for treating endocrine disorder type infertility. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of ginseng, 15-25 parts of wolfberry, 10-20 parts of Chinese angelica, 2-8 parts of propolis, 7-10 parts of jasmine, 2-4 parts of malt, 3-5 parts of liquorice, 5-15 parts of honeysuckle, 2-6 parts of green onion, 10-15 parts of herba epimedii, 15-25 parts of radix bupleuri, 8-17 parts of artemisia anomala, and 20-30 parts of madder. The traditional Chinese medicine composition has the obvious effect for treating endocrine disorder type infertility, therefore, a patient can be pregnant and has the right of being a mother, and furthermore, the traditional Chinese medicine composition has the effects of nourishing uterus, conditioning an internal physiological system and recovering and supplying damaged internal energy and qi. The raw materials of the traditional Chinese medicine composition disclosed by the invention are mainly selected from local common medicinal materials, therefore, the cost is low, and the economical burden of patients can be lightened.

Description

A kind ofly treat infertile Chinese medicine composition of endocrine disturbance's type and preparation method thereof
Technical field
The invention discloses one and treat the infertile Chinese medicine composition of endocrine disturbance's type, especially a kind ofly treat infertile Chinese medicine composition of endocrine disturbance's type and preparation method thereof, the invention belongs to traditional Chinese medicine field.
Background technology
Endocrine is the regulation and control person of human physiological functions, and it is played a role in human body by secreting hormone.Such as, antibacterial enters human body, and thymosin just can increase secretion automatically, to resist pathogenic bacteria; Female menstrual period, progestogen also can increase, and estrogen is corresponding minimizing then.If because some cause of disease, the hormonosis causing endocrine gland to secrete or very few, metabolic function is disorderly, will cause endocrine disturbance, cause endocrinopathy to occur, comprise female acyesis.
Common manifestation: luteal phase defect is the infertile modal performance of dyscrinic.Women's luteal phase defect has many harm to health.Luteal phase defect main manifestations be menstrual cycle shorten but menstrual period normal, through to measure normally or slightly many, companion's history of spontaneous abortion.Often auxiliary examination need be relied on to make a definite diagnosis.In fact, the Recurrent spontaneous abortion of nearly 35% ~ 40% is caused by luteal phase defect.During normal pregnancy, ovum starts the implantation of film implantation in uterus at after fertilization 5 ~ 7d, and trophoblastic cell starts to secrete chorionic-gonadotropin hormone (HCG), and HCG stimulates corpus luteum continuation growth to grow up, and becomes corpus luteum of pregnancy, makes progesterone continue to produce.When gestation plays luteal function decline for 6 weeks, trophoblast synthesis progesterone starts.Therefore the most easily miscarry when pregnant 6 ~ 7 weeks.As luteal phase defect comprises the corpus luteum lost of life, and corpus luteum secretory function is low, so that progesterone secretion quantity not sufficient, after the bad or early pregnancy of endometrial secretory reaction, decidua reaction is bad, cause cytula not easily after implantation or implantation development of fertilized ovum be affected, cause miscarriage.Luteal phase defect is large on female pathology impact, and women occurs that the symptom of luteal phase defect needs timely hospital treatment.
Disease reason: 1, ovulation failure: the various endocrine function ovulation failure caused of lacking of proper care all can directly cause infertile.
2, congenital disorders of sex differentiation: mainly comprise Hyperandrogenism, hypoandrogenism, the diseases such as androgen dysfunction.3, the amenorrhea that causes of endocrine factors: amenorrhea is a kind of extremely form of infrequent menstruation.Primary amenorrhea and secondary amenorrhea can be divided into.Primary amenorrhea to refer to after women 18 one full year of life the still menolipsis person of rising; Secondary amenorrhea refers to once well-regulated menstruation, and causes for a certain reason and stop menstruation more than 3 months persons.4, polycystic ovary syndrome: there is menoxenia, amenorrhea, anovulation hirsutism, obesity, the increase of infertile merging bilateral ovaries in many capsule changes.5, hirsutism is with manlike: hirsutism refers to compared with women and its women of the same age of the same clan, or compared with before he or she's disease, hair undue growth, thicker, blackening.Manlike is a kind of clinical syndrome, refers to that women is except performance hirsutism, still have clitoridauxe, muscular, have a low and deep voice, facial acne, male pattern alopecia, women's secondary sex characteristics go down or disappear and amenorrhea etc.Hirsutism and butch be to increase in various degree or caused by whole non-organ increases androgenic sensitivity because a variety of causes causes body inner estrogen level.6, high lactogenic mass formed by blood stasis: Prolactin is abnormal too high infertilely or sterile comprises amenorrhea, galactorrhea, hypomenorrhea and rare, luteal phase defect and ovulation.7, thyroid: hyperthyroidism, go down, struma lymphomatosa etc. all can affect ovulation and cause infertile.9, luteal phase defect: menstruation in advance, dripping not to the utmost, palace blood forms anovulation type menstruation etc.10, other as: diabetes, adrenal gland's cryptorrhea etc. also can affect ovary ovulation.
Endocrine disturbance is the major reason causing female acyesis, and the foundation of normal ovulatory cycle needs hypothalamic-pituitary-ovarian s function normal in fact.Wherein any one position dysfunction all may cause not ovulating, and thus causes menolipsis, hypomenorrhea, anovulatory dysfunctional uterine hemorrhage etc., carries out causing infertility, the infertility caused due to this endocrine reason and dyscrinic infertile.Along with the development of Chinese Chinese medicine, on treatment dyscrinic is infertile, it is little that people appreciate the infertile side effect for the treatment of by Chinese herbs dyscrinic gradually, bear painful little advantage, and Chinese traditional treatment great attention to whole idea, pay attention to comprehensive control, pay attention to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therapeutic effect demonstrates treatment by Chinese herbs dyscrinic infertile advantage more.Chinese medicine has endocrine regulation, compensate qi and blood, improves qi-blood circulating, the special efficacy of hard masses softening and resolving, and persistent, treating both the principal and secondary aspects of a disease, has no side effect and efficacy consolidation, not easily to recur.
Summary of the invention
Along with the development of Chinese Chinese medicine, on Cure and control endocrine disturbance type is infertile, people gradually appreciate treatment by Chinese herbs endocrine disturbance type sterility treatment process and have no side effect, patient bears painful little, the advantage that cost is saved relatively, for the present situation that existing western medical treatment endocrine disturbance type is infertile, an object of the present invention is that providing a kind of treats the infertile Chinese medicine composition of endocrine disturbance's type, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, each raw material is as follows, be weight portion: Radix Ginseng 10-20, Fructus Lycii 15-25, Radix Angelicae Sinensis 10-20, propolis 2-8, Fructus Gardeniae 7-10, Fructus Hordei Germinatus 2-4, Radix Glycyrrhizae 3-5, Flos Lonicerae 5-15, Herba Alii fistulosi 2-6, Herba Epimedii 10-15, Radix Bupleuri 15-25, Herba Artemisiae Anomalae 8-17, Radix Rubiae 20-30.
A kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, preferred scheme, each raw material is as follows, is weight portion: Radix Ginseng 13-18, Fructus Lycii 18-23, Radix Angelicae Sinensis 13-18, propolis 4-6, Fructus Gardeniae 8-9, Fructus Hordei Germinatus 2.5-3.5, Radix Glycyrrhizae 3.5-4.5, Flos Lonicerae 8-13, Herba Alii fistulosi 3-5, Herba Epimedii 11-14, Radix Bupleuri 18-23, Herba Artemisiae Anomalae 10-15, Radix Rubiae 23-28.
A kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, better preferred scheme, each raw material is as follows, be weight portion: Radix Ginseng 15, Fructus Lycii 20, Radix Angelicae Sinensis 15, propolis 5, Fructus Gardeniae 8.5, Fructus Hordei Germinatus 3, Radix Glycyrrhizae 4, Flos Lonicerae 10, Herba Alii fistulosi 4, Herba Epimedii 12.5, Radix Bupleuri 20, Herba Artemisiae Anomalae 13, Radix Rubiae 25.
Another object of the present invention is just to provide the infertile preparation method of above-mentioned treatment endocrine disturbance type.
Treat a preparation method for the infertile Chinese medicine composition of endocrine disturbance's type, be prepared from primarily of following step:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir and fry 1-5 minute, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, the thick paste thing high temperature sterilize 3-7 smashed to pieces is placed on roasting 2-6 minute in microwave oven second, and taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get mixing medicamental pulverata 2-3 Mel doubly, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 2-6 minute with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 80-120 mesh sieve stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 90-100 DEG C, rapid ebuillition of heated 3-5 minute, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 20-40 minute, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 3-5 time, is placed in electric cooker, add Radix Rubiae weight 3-8 clear water doubly, boil to boiling, after boiling 10-20 minute, add step 3.-4. gains, turn slow fire boiling 30-50 minute, namely obtain compositions according to every part of 5-10ml subpackage.
The preparation method of above-mentioned Chinese medicine composition, 1. step drops into the Fructus Hordei Germinatus and Radix Glycyrrhizae that cut, constantly stirs and fries 2-4 minute (preferred, to drop into the Fructus Hordei Germinatus and Radix Glycyrrhizae that cut, constantly stir stir-fry 3 minutes).
The preparation method of above-mentioned Chinese medicine composition, 2. the thick paste thing high temperature sterilize 4-6 smashed to pieces is placed on roasting 3-5 minute (preferred, within 5 seconds, to be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and to bake 4 minutes) in microwave oven second by step.
The preparation method of above-mentioned Chinese medicine composition, 3. step gets mixing medicamental pulverata 2.3-2.8 Mel doubly (preferred, to get the Mel of mixing medicamental pulverata 2.5 times).
The preparation method of above-mentioned Chinese medicine composition, step is grinds 4., crosses 90-110 mesh sieve stand-by (preferred, grinds, crosses 100 mesh sieves stand-by).
The preparation method of above-mentioned Chinese medicine composition, step, 4. by Radix Angelicae Sinensis and propolis mixing, adds the hot water (preferred, by Radix Angelicae Sinensis and propolis mixing, to add the hot water of 95 DEG C) of 93-98 DEG C.
The preparation method of above-mentioned Chinese medicine composition, 5. step adds Radix Rubiae weight 4-7 clear water doubly, boils to boiling, treats boiling 13-18 minute (preferred, to add the clear water of Radix Rubiae weight 5.5 times, boil to boiling, treat boiling 15 minutes).
The infertile Be very effective of this Chinese medicine composition Endocrine dysfunctional, not only makes patient be pregnant to nurse a baby youngster to do the right of mother, maintains uterus in addition, nurse one's health effect of inherent physiological system, can recover and supplement the inherent true strength, the vital qi that have damaged.The local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Radix Ginseng: sweet in the mouth, micro-hardship is warm in nature, flat.Return spleen, lung meridian, heart channel.QI invigorating, Gu de-, promote the production of body fluid, calm the nerves, Fructus Alpiniae Oxyphyllae, weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.
Radix Angelicae Sinensis: it has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.
Fructus Lycii: the flat sweet in the mouth of Fructus Lycii property, has effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, lung moistening.Pass through chemical composition analysis, the fruit of Fructus Lycii detects containing nutritional labelings such as abundant carotene, vitamin C, Fructus Lycii proteoglycan, betanin, linoleic acid and ferrum, phosphorus, calcium, has tonify deficiency to calm the nerves, improving eyesight is dispeled the wind, the effect such as nourishing kidney lung moistening and hepatoprotective antitumor.Pharmacological action: have influence to immunologic function.Nature and flavor: Fructus Lycii: sweet are flat.Folium Lycii: bitter, sweet; Cool in nature.Function: Fructus Lycii: nourishing the liver, nourishing kidney, lung moistening.Folium Lycii: tonify deficiency benefit essence, clearing away heat to improve acuity of vision.
Propolis: antibacterial, the looks improving and the skin nourishing that propolis has, the effect of promotion cell regeneration, this has just been doomed the critical role of propolis in skin care item industry, it not only can eliminate fungal infection, pigment can also be decomposed, calm down wrinkle, delaying senility, accelerate the healing of histiocytic regeneration and wound, also have good curative effect to small pox left pox scar pox print.Recent studies proves, enriching and the bioactive substance of uniqueness contained by propolis, make it have the several functions such as antibacterial, antiinflammatory, antipruritic, antioxidation, enhancing immunity, blood sugar lowering, blood fat reducing, antitumor, medical treatment, health-care effect is widely had to human body, now become the focus of various countries' scientific research, and become emerging health product and extremely praise highly.Antibacterial action.The sterilizing of propolis energy, sterilization, sterilization, antibacterial, mildew-resistant, anticorrosion, solve the defect that antibiotic only works to single microorganism, and be free from side effects.Good therapeutic effect is had in daily life to dermatosis.Antivirus action.Propolis is natural antiviral substance, has very strong suppression and killing action to multiple virus.Antioxidation.Propolis is called as antioxidant and free radical scavenger, effectively can remove the refuses such as excess activated oxygen because the bad life habits such as fat, overworked, environmental pollution, smoking and extraneous factor produce and free radical.Enhancing immunity effect.The immune system of human body is easily infracting by virus, and propolis can strengthen body immunity, strengthens the ability of human body opposing virus infraction.Antitumaous effect.Both at home and abroad large quantifier elimination shows, propolis has good effect pressing down cancer anticancer aspect.Promote cell regeneration effect.Propolis can accelerate the healing of tissue regeneration and wound.Effects of beautification and nourishing face.Propolis can decompose pigment, calm down wrinkle, delaying senility etc., is women's cosmetic good merchantable brand.Analgesic activity.Propolis also has good effect in analgesia.Prophylaxis of tumours.Containing abundant cancer-resisting substance in propolis, research proves, endocrine disturbance's type infertile patient after taking propolis, can cancerous cell be reduced and chemotherapy can be alleviated, side effect that radiotherapy causes.Resisting hypertension.Suffering from hypertensive patient takes containing very many Flavonoid substances and the propolis with very strong anti-oxidation ability continuously, not only can reduce over the harm of lipid oxide to blood vessel, prevent sclerosis of blood vessels, and effectively can also reduce the content of triglyceride, reduce platelet aggregation, improve microcirculation, too high blood pressure can be reduced, prevent the generation of unexpected thing.Thus, middle-aged and elderly people, particularly hypertension, heart disease, arteriosclerosis patient, usually take propolis, quite has benifit to good health and a long life.
Fructus Gardeniae: the l belonging to Ministry of Public Health promulgation criticizes medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.The diseases such as treatment icterohepatitis, bruise, hypertension, diabetes are usually used in, heat clearing away, pathogenic fire purging, removing heat from blood at tcm clinical practice.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.
Fructus Hordei Germinatus: return spleen, stomach warp.Effect promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, galactopoiesis relieving distension.Cure mainly and do not disappear for food stagnation, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, and women weans, hypochondriac pain due to stagnation of liverQI, stomachache due to hyperactive liver-QI attacking the stomach.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Function of relieving cough and calming asthma enoxolone has obvious central antitussive effect, and heavy dose of enoxolone can make mouse breathing suppress.In addition glycyrrhizin, glycyrrhetate still have anti-inflammatory and antiallergic, anti-liver injury, anti-promoting, antibacterial, anti AIDS virus (glycyrrhizin) effect.
Flos Lonicerae: modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.
Herba Alii fistulosi: Herba Alii fistulosi: another name and thing grass, onion, dish primary, HUOCONG, the four seasons Herba Alii fistulosi.Flavor efficacy is pungent, and temperature, enters lung, stomach warp.Exterior-excess hollow, rise to fall more and lack, merit is specially dispersed and is activated yang, can expelling wind and cold pathogens, and diaphoresis expelling pathogenic factors from muscles, is used for the treatment of the mild of typhoid fever, cold and heat headache; Again can item, sharp key, relieving constipation, activate yang gas and loose YIN-cold, be used for the treatment of QI and blood cohesion, dizzy headache, QI stagnated by cold, abdominal distention is suffered from abdominal pain, and bladder qi dysfunction and dysuria etc.; In addition still tool removing toxic substances, hemostatic function.Energy activating yang to invigorate blood circulation, anthelmintic removing toxic substances, relieving the exterior syndrome by diaphoresis.Cure mainly the diseases such as anemofrigid cold mild, carbuncle sore tumefacting virus, dysentery faint pulse, cold coagulation stomachache, dysuria, have good therapeutical effect to flu, wind and cold, headache, YIN-cold stomachache, malnutrition due to parasitic infestation internal resistance, dysentery etc.1. antipyretic, eliminate the phlegm: the volatilization wet goods effective ingredient of Herba Alii fistulosi, have and stimulate health sweat gland, reach the effect of diaphoresis heat radiation; Scallion oil stimulates upper respiratory tract, makes sticky expectorant be easy to bring up.2. facilitating digestion absorbs: Herba Alii fistulosi also has the effect stimulating body digestive juice secretion, can spleen benefiting and stimulating the appetite, appetite stimulator.3. antibacterial, antiviral 4. cancer-resisting.
Herba Epimedii: Herba Epimedii nature and flavor are pungent, sweet, temperature, there is kidney invigorating and YANG supporting, bone and muscle strengthening, invigorate vital energy and reinforce the heart, effect of expelling wind and removing dampness, be applicable to the soft disease such as unable for the treatment of sexual impotence, seminal emission, premature ejaculation, sexual disorder, menoxenia, climacteric syndrome, hypertension, rheumatalgia, hemiplegia, numb limbs and tense tendons, knee joint.Modern medicine study is thought, Herba Epimedii has the gonepoietic effect of promotion; There is lasting hypotensive activity; There is the effect of anti-streptococcus pneumoniae, tubercule bacillus, staphylococcus aureus.
Radix Bupleuri: another name ground smoke, mountain dish, mushroom grass, faggot, nature and flavor hardship, be slightly cold, return liver, gallbladder meridian.There is reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Herba Artemisiae Anomalae: it has hemostasis of curing the wound, and removing blood stasis stimulates the menstrual flow, promoting digestion and removing stagnation, the effect of appetizing of being amusing.It can be used for acute icterohepatitis, toothache, chronic tracheitis, stomatitis, pharyngolaryngitis, tonsillitis, nephritis, malaria; Eye conjunctivitis is controlled in external, otitis media, skin infection, eczema, traumatic hemorrhage.
Radix Rubiae: removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulates the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.
1, Chinese medicine composition of the present invention " more holistic ", both endocrine disturbance's type can have been treated infertile, scalable endocrine again, most importantly the Chinese crude drug of different efficacies is combined, this is the large feature being different from Drug therapy, and this Chinese medicine composition is prepared from according to Chinese medicine principle completely, more safe and reliable, without any side effects, to matrix without any stimulation.
2, Chinese medicine composition of the present invention meets the infertile principle of Chinese traditional treatment endocrine disturbance type.The medical material selected has effect of endocrine regulation, and strongly fragrant depressed, the pain relieving of the heart of releiving, arresting convulsion of calming the nerves, Endocrine disorder type infertile patient has fabulous therapeutical effect, be treat the infertile ideal medicine of endocrine disturbance's type at present, and have unique curative effect to the disease such as uterine hypoplasia and ovarian hypofunction.
3, selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, and adopt modern advanced pharmaceutical technology to make, evident in efficacy, safe without toxic side effect, treating both the principal and secondary aspects of a disease, should be widely promoted application.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1a kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, each raw material is as follows, be weight portion (getting 10g for every part): Radix Ginseng 10, Fructus Lycii 15, Radix Angelicae Sinensis 10, propolis 3, Fructus Gardeniae 7, Fructus Hordei Germinatus 2, Radix Glycyrrhizae 3, Flos Lonicerae 5, Herba Alii fistulosi 13, Herba Epimedii 10, Radix Bupleuri 15, Herba Artemisiae Anomalae 8, Radix Rubiae 20.
The Chinese medicine composition that treatment endocrine disturbance type is infertile, preparation process is as follows:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir stir-fry 1 minute, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, within 3 seconds, be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and bake 2 minutes, taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get the Mel of mixing medicamental pulverata 2 times, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 2 minutes with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 80 mesh sieves stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 90 DEG C, rapid ebuillition of heated 3 minutes, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 20 minutes, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 3 times, is placed in electric cooker, add the clear water of Radix Rubiae weight 3 times, boil to boiling, until boiling after 10 minutes, add step 3.-4. gains, turn slow fire boiling 30 minutes, namely obtain compositions according to every part of 5ml subpackage.
model case one:zou XX, female, 30 years old, Jiyang County, Jinan City, Shandong Province personage, patient's first time is time conceived, because cause is in conversion period, so done abortion, after 2 years, patient's second pregnancy, because health does not adjust to optimum state, therefore second child does not also stay, and after 1 year, patient's third time is conceived, conceived 45 days time, vaginal hemorrhage, finds that there is the symptom of threatened abortion through examination in hospital, after suitable treatment, invalid, spontaneous abortion after conceived 50 days.After this all could not cherish upper child again more than 2 years, be the infertile symptom caused because repeatedly miscarrying through examination in hospital, because repeatedly miscarriage causes the frequent waist of patient to ache, and xerosis cutis, matt.Spirit depressing, body constitution declines, and goes examination in hospital to be the infertile and spontaneous abortion that endocrine disturbance causes.
Take embodiment 1 gained Chinese medicine composition, take 1 month, aching pain in waist and back symptom alleviates; Use 1 first quarter moon, skin starts to reappear gloss, flexible; Use 2 months, body constitution and complexion are obviously improved, and people has also become vigor; Use after 3 months, conceived, give birth to a girl baby smoothly afterwards, child is very healthy.
embodiment 2a kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, each raw material is as follows, be weight portion (getting 10g for every part): Radix Ginseng 20, Fructus Lycii 25, Radix Angelicae Sinensis 20, propolis 8, Fructus Gardeniae 10, Fructus Hordei Germinatus 4, Radix Glycyrrhizae 5, Flos Lonicerae 15, Herba Alii fistulosi 18, Herba Epimedii 15, Radix Bupleuri 25, Herba Artemisiae Anomalae 17, Radix Rubiae 30.
The Chinese medicine composition that treatment endocrine disturbance type is infertile, preparation process is as follows:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir stir-fry 5 minutes, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, within 7 seconds, be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and bake 6 minutes, taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get the Mel of mixing medicamental pulverata 3 times, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 6 minutes with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 120 mesh sieves stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 100 DEG C, rapid ebuillition of heated 5 minutes, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 40 minutes, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 5 times, is placed in electric cooker, add the clear water of Radix Rubiae weight 8 times, boil to boiling, until boiling after 20 minutes, add step 3.-4. gains, turn slow fire boiling 50 minutes, namely obtain compositions according to every part of 10ml subpackage.
embodiment 3:a kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, each raw material is as follows, be weight portion (getting 10g for every part): Radix Ginseng 13, Fructus Lycii 18, Radix Angelicae Sinensis 13, propolis 4, Fructus Gardeniae 8, Fructus Hordei Germinatus 2.5, Radix Glycyrrhizae 3.5, Flos Lonicerae 8, Herba Alii fistulosi 14, Herba Epimedii 11, Radix Bupleuri 18, Herba Artemisiae Anomalae 10, Radix Rubiae 23.
The Chinese medicine composition that treatment endocrine disturbance type is infertile, preparation process is as follows:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir stir-fry 2 minutes, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, within 4 seconds, be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and bake 3 minutes, taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get the Mel of mixing medicamental pulverata 2.3 times, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 3 minutes with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 90 mesh sieves stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 90-100 DEG C, rapid ebuillition of heated 3 minutes, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 25 minutes, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 5 times, is placed in electric cooker, add the clear water of Radix Rubiae weight 4 times, boil to boiling, until boiling after 13 minutes, add step 3.-4. gains, turn slow fire boiling 35 minutes, namely obtain compositions according to every part of 6ml subpackage.
embodiment 4a kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, each raw material is as follows, be weight portion (getting 10g for every part): Radix Ginseng 18, Fructus Lycii 23, Radix Angelicae Sinensis 18, propolis 7, Fructus Gardeniae 9, Fructus Hordei Germinatus 3.5, Radix Glycyrrhizae 4.5, Flos Lonicerae 13, Herba Alii fistulosi 17, Herba Epimedii 14, Radix Bupleuri 23, Herba Artemisiae Anomalae 15, Radix Rubiae 28.
The Chinese medicine composition that treatment endocrine disturbance type is infertile, preparation process is as follows:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir stir-fry 4 minutes, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, within 6 seconds, be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and bake 5 minutes, taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get the Mel of mixing medicamental pulverata 2.8 times, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 5 minutes with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 110 mesh sieves stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 98 DEG C, rapid ebuillition of heated 5 minutes, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 35 minutes, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 5 times, is placed in electric cooker, add the clear water of Radix Rubiae weight 7 times, boil to boiling, until boiling after 18 minutes, add step 3.-4. gains, turn slow fire boiling 45 minutes, namely obtain compositions according to every part of 9ml subpackage.
model case two:high XX, female, 528 years old, people from Jinan City, Shandong Province, patient marries, after marriage because of working principle for 25 years old, play small pox on the face, menstruation is postponed often, and sometimes and over two months once, pregnancy has all been artificial abortion twice, and Post operation does not have a good rest, when wanting baby afterwards, in 2 years, natural artificial abortion 3 times, is that dyscrinic is infertile through hospital diagnosis.
Take embodiment 4 gained Chinese medicine composition, after taking 2 months, undergo another pregnancy, phenolics, monthly take embodiment 2 gained Chinese medicine composition 2 days, through examination in hospital, do not find that there is miscarriage sign, the mature smooth production of rear child, period has no adverse reaction.
embodiment 5a kind ofly treat the infertile Chinese medicine composition of endocrine disturbance's type, each raw material is as follows, be weight portion (getting 10g for every part): Radix Ginseng 15, Fructus Lycii 20, Radix Angelicae Sinensis 15, propolis 5.5, Fructus Gardeniae 8.5, Fructus Hordei Germinatus 3, Radix Glycyrrhizae 4, Flos Lonicerae 10, Herba Alii fistulosi 15.5, Herba Epimedii 12.5, Radix Bupleuri 20, Herba Artemisiae Anomalae 13, Radix Rubiae 25.
The Chinese medicine composition that treatment endocrine disturbance type is infertile, preparation process is as follows:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir stir-fry 3 minutes, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, within 5 seconds, be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and bake 4 minutes, taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get the Mel of mixing medicamental pulverata 2.5 times, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 4 minutes with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 100 mesh sieves stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 95 DEG C, rapid ebuillition of heated 4 minutes, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 30 minutes, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 4 times, is placed in electric cooker, add the clear water of Radix Rubiae weight 5.5 times, boil to boiling, until boiling after 15 minutes, add step 3.-4. gains, turn slow fire boiling 40 minutes, namely obtain compositions according to every part of 8ml subpackage.
experimental example:clinical data: 1, physical data :be diagnosed as endocrine disturbance's type infertile patient through histopathology and cytolgical examination, the age is between 20-40; Important organ function of organization is normal.The patient meeting this research inclusion criteria is 200 examples.
2, Therapeutic Method: prepared Chinese medicine composition day takes 2 times, takes, each serving 5-10ml with meal
3, criterion of therapeutical effect: effective: common sympton alleviates substantially is invalid: malaise symptoms is all unchanged.In order to verify the effect of Chinese medicine composition of the present invention, We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis having been carried out to data.
Specific experiment result is as following table:
Table 1:
Prove through clinical trial, compared with the means using Chinese medicine composition of the present invention infertile with western medical treatment endocrine disturbance type, rapid-action, treatment means is more comprehensive thoroughly, have no side effect between the operating period, while treatment endocrine disturbance type is infertile, can alleviate by symptoms such as infertile infertile, the stomachache brought of endocrine disturbance's type.Prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 99%, good therapeutical effect is all had for endocrine disturbance's type is infertile, for endocrine disturbance's type infertile patient, use Chinese medicine composition of the present invention, while effective treatment endocrine disturbance type is infertile, can also blood pressure lowering, therefore Chinese medicine composition of the present invention a kind ofly treats the infertile medicine of endocrine disturbance's type safely and effectively.

Claims (10)

1. treat the infertile Chinese medicine composition of endocrine disturbance's type for one kind, it is characterized in that: each raw material is as follows, be weight portion: Radix Ginseng 10-20, Fructus Lycii 15-25, Radix Angelicae Sinensis 10-20, propolis 2-8, Fructus Gardeniae 7-10, Fructus Hordei Germinatus 2-4, Radix Glycyrrhizae 3-5, Flos Lonicerae 5-15, Herba Alii fistulosi 2-6, Herba Epimedii 10-15, Radix Bupleuri 15-25, Herba Artemisiae Anomalae 8-17, Radix Rubiae 20-30.
2. the Chinese medicine composition that treatment endocrine disturbance type according to claim 1 is infertile, it is characterized in that: each raw material is as follows, is weight portion: Radix Ginseng 13-18, Fructus Lycii 18-23, Radix Angelicae Sinensis 13-18, propolis 4-6, Fructus Gardeniae 8-9, Fructus Hordei Germinatus 2.5-3.5, Radix Glycyrrhizae 3.5-4.5, Flos Lonicerae 8-13, Herba Alii fistulosi 3-5, Herba Epimedii 11-14, Radix Bupleuri 18-23, Herba Artemisiae Anomalae 10-15, Radix Rubiae 23-28.
3. the Chinese medicine composition that treatment endocrine disturbance type according to claim 1 is infertile, it is characterized in that: each raw material is as follows, be weight portion: Radix Ginseng 15, Fructus Lycii 20, Radix Angelicae Sinensis 15, propolis 5, Fructus Gardeniae 8.5, Fructus Hordei Germinatus 3, Radix Glycyrrhizae 4, Flos Lonicerae 10, Herba Alii fistulosi 4, Herba Epimedii 12.5, Radix Bupleuri 20, Herba Artemisiae Anomalae 13, Radix Rubiae 25.
4. the preparation method of the Chinese medicine composition that the treatment endocrine disturbance type according to any one of claim 1-3 is infertile, is characterized in that: step is as follows:
1. Fructus Hordei Germinatus and Radix Glycyrrhizae are cleaned, cut into chunks, put by wheat bran in pot to add and propagandize ZHILING hotly and to live state, drop into the Fructus Hordei Germinatus that cuts and Radix Glycyrrhizae, constantly stir and fry 1-5 minute, sieve removes wheat bran, dries in the air the Fructus Hordei Germinatus fried and Radix Glycyrrhizae to crisp, and it is stand-by to grind to form smalls;
2. cleaned by fresh Herba Alii fistulosi, be cut into the block of soybean grain size, be pounded thick paste with rolling pin, the thick paste thing high temperature sterilize 3-7 smashed to pieces is placed on roasting 2-6 minute in microwave oven second, and taking-up cools stand-by;
3. by step 1.-2. gained medicamental pulverata mixing, get mixing medicamental pulverata 2-3 Mel doubly, Mel be placed in the hot pot that dryouies, when thawing fired completely by Mel, put into mixing medicamental pulverata, stir 2-6 minute with large ferrum spoon, dry in the air cool stand-by;
4. Radix Ginseng, Fructus Lycii, Fructus Gardeniae, Flos Lonicerae, Herba Epimedii, Radix Bupleuri and Herba Artemisiae Anomalae are picked impurity, grinds, cross 80-120 mesh sieve stand-by, fresh Radix Angelicae Sinensis is dried, is rolled into powder, by Radix Angelicae Sinensis and propolis mixing, add the hot water of 90-100 DEG C, rapid ebuillition of heated 3-5 minute, filters, pours in filtrate by the fine powder after sieving, said mixture is endured 20-40 minute, get clean plate, smear last layer Oleum sesami at tray bottom wall, cool stand-by;
5. Radix Rubiae is eluriated 3-5 time, is placed in electric cooker, add Radix Rubiae weight 3-8 clear water doubly, boil to boiling, after boiling 10-20 minute, add step 3.-4. gains, turn slow fire boiling 30-50 minute, namely obtain compositions according to every part of 5-10ml subpackage.
5. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: 1. step drops into the Fructus Hordei Germinatus and Radix Glycyrrhizae that cut, constantly stirs and fries 2-4 minute (preferred, to drop into the Fructus Hordei Germinatus and Radix Glycyrrhizae that cut, constantly stir stir-fry 3 minutes).
6. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that: 2. the thick paste thing high temperature sterilize 4-6 smashed to pieces is placed on roasting 3-5 minute (preferred, within 5 seconds, to be placed on by the thick paste thing high temperature sterilize smashed to pieces in microwave oven and to bake 4 minutes) in microwave oven second by step.
7. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: 3. step gets mixing medicamental pulverata 2.3-2.8 Mel doubly (preferred, to get the Mel of mixing medicamental pulverata 2.5 times).
8. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: step is grinds 4., crosses 90-110 mesh sieve stand-by (preferred, grinds, crosses 100 mesh sieves stand-by).
9. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: step, 4. by Radix Angelicae Sinensis and propolis mixing, adds the hot water (preferred, by Radix Angelicae Sinensis and propolis mixing, to add the hot water of 95 DEG C) of 93-98 DEG C.
10. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: 5. step adds Radix Rubiae weight 4-7 clear water doubly, boils to boiling, treat that boiling 13-18 minute is (preferred, add the clear water of Radix Rubiae weight 5.5 times, boil to boiling, treat boiling 15 minutes).
CN201510231638.0A 2015-05-08 2015-05-08 Traditional Chinese medicine composition for treating endocrine disorder type infertility and preparation method thereof Pending CN104784587A (en)

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Application publication date: 20150722