CN103908579A - Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof - Google Patents

Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof Download PDF

Info

Publication number
CN103908579A
CN103908579A CN201410144867.4A CN201410144867A CN103908579A CN 103908579 A CN103908579 A CN 103908579A CN 201410144867 A CN201410144867 A CN 201410144867A CN 103908579 A CN103908579 A CN 103908579A
Authority
CN
China
Prior art keywords
parts
hour
preparation
radix
spleen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410144867.4A
Other languages
Chinese (zh)
Inventor
陈欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510904009.XA priority Critical patent/CN105434862A/en
Priority to CN201510904258.9A priority patent/CN105395870A/en
Priority to CN201410144867.4A priority patent/CN103908579A/en
Priority to CN201510904259.3A priority patent/CN105412599A/en
Priority to CN201510904383.XA priority patent/CN105412600A/en
Priority to CN201510904486.6A priority patent/CN105395872A/en
Priority to CN201510904490.2A priority patent/CN105434863A/en
Priority to CN201510904350.5A priority patent/CN105395871A/en
Priority to CN201510904239.6A priority patent/CN105477336A/en
Priority to CN201510904489.XA priority patent/CN105412601A/en
Publication of CN103908579A publication Critical patent/CN103908579A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a spleen and stomach tonifying preparation for resisting side effects of chemotherapy. The preparation is prepared from the following main raw materials in parts by weight: 5-9 parts of radix paeoniae alba, 6-12 parts of salviae miltiorrhizae, 3-9 parts of rhizoma bletillae, 6-15 parts of poria cocos, 8-15 parts of eupatorium, 20-35 parts of puerarin, 4-12 parts of coptis chinensis, 6-15 parts of artemisia anomala, 4-9 parts of rhizoma atractylodis macrocephalae, 3-9 parts of semen Cuscutae, 3-7 parts of rhizoma atractylodis, 2-8 parts of fructus psoraleae (processed by salt), 2-6 parts of radix clematidis and 3-8 parts of pollen pini. The materials selected by the preparation are traditional Chinese medicinal materials which are free from any toxic and side effects, and the preparation has a good treatment effect to side effects caused by chemotherapy and has the function of tonifying spleen and stomach.

Description

Invigorating the spleen and regulating the stomach preparation and the method for making of anti-chemotherapy side effect
Technical field
The invention discloses a kind of invigorating the spleen and regulating the stomach preparation, invigorating the spleen and regulating the stomach preparation and the method for making of especially anti-chemotherapy side effect.The invention belongs to Chinese medicine field.
Background technology
Chemotherapy, is to treat disease by chemical substance, is one of Main Means for the treatment of at present tumor and some autoimmune disease.It is a kind of therapeutic modality that utilizes chemicals to kill the growth and breeding of tumor cell, inhibition tumor cell and promote the differentiation of tumor cell, it is that a kind of systemic treatment means all have therapeutical effect to primary tumor, metastasis and subclinical metastasis, but chemotherapeutic treatment tumor is in killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so be the Therapeutic Method of a kind of " destruction of all people good and bad alike ".
Tumor illness, is main mainly with chemotherapeutic treatment in early days, and mostly the course of disease is lasted longlyer, and prolonged illness easily consumes impairment of QI the moon, and the symptoms such as dry mouth and throat, health be weak easily appear in the therefore disease of the common deficiency of both QI and YIN of tumor patient; And chemotherapy mostly is chemistry poison, each radiotherapy all directs at taste, can cause following side effect to taste: weakness of the spleen and stomach, abnormal ascending-descending of QI and occur playing abdominal distention and pain, nausea and vomiting, health is tired, the symptoms such as lassitude, in addition, also normal with general reaction, the immunologic function degression etc. relevant with chemotherapy.Weakness of the spleen and stomach the foundation of acquired constitution is impaired, and insufficiency of vital energy and blood causes deficiency of qi and yin more.So move in circles, the state of an illness is difficult for taking a turn for the better more.The digestive tract reaction causing after chemotherapy of tumors belongs to the categories such as the traditional Chinese medical science " stomach painful abdominal mass ", " vomiting ", and, mainly at the five internal organs, there are much relations its sick position with taste: taste are become estranged, weakness of the spleen and stomach, deficiency of both QI and YIN are main pathologic basis.
Chemotherapy has certain therapeutic effect to tumor, the slight illness of reduction of patient to a certain extent, improve the curative effect of tumor, but the toxic and side effects of chemotherapy produces very large inhibitory action to taste, so develop the medicine of anti-chemotherapy side effect, make tumor patient can better the tool of receiving treatment be of great significance.Chinese medicine, aspect this reaction of improvement, has obvious advantage, and what be still really developed to new drug is not a lot, and the medication effect of having developed is also not obvious.Invigorating the spleen and regulating the stomach preparation of the present invention is to consult on the basis of a large amount of documents and materials and clinical trial, become estranged and the main pathogenesis of deficiency of both QI and YIN for weakness of the spleen and stomach, taste due to chemotherapy, in significantly improving the toxicity that chemotherapy causes taste, can also improve patient's immunologic function, hemopoietic function of bone marrow etc., improve patient thereby reach, the object that strengthens patient body quality, better receives treatment patient, to improve patient's cure rate.
Application publication number is CN 102327390A(application number 201110314905.2) Chinese patent literature a kind of by name " a kind of preparation method of Chinese prescription and the pill thereof of preventing and treating chemotherapy toxic side effect " disclosed, this Chinese prescription is made up of according to certain weight proportion Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Cistanches, Cornu Cervi Pantotrichum, Moschus, Stalactitum, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Stichopus japonicus, Radix Glycyrrhizae, Colla cornus cervi, yellow wine.Its formula medical material is numerous, and indivedual price of medicinal material is higher, has increased patient's financial burden.Application publication number is CN 103623338A(application number 201310275217.9) Chinese patent literature a kind of by name " Chinese medicine granules for the treatment of digestive tract side effects caused by cancer chemotherapy and preparation method thereof " disclosed, this Chinese medicine granules by Radix Astragali 600-800g, Radix Ophiopogonis 250-350g, Radix Ginseng Rubra 150-250g, Rhizoma Atractylodis Macrocephalae (parched with bran) 150-250g, Poria 150-250g, Radix Glycyrrhizae 200-300g, Radix Scrophulariae 200-300g, Radix Angelicae Sinensis 200-300g, Fructus Mume 250-350g, Rhizoma Pinelliae Preparatum 250-350g, Herba Pogostemonis 200-300g, Pericarpium Citri Reticulatae 200-300g, Rhizoma Curcumae 200-300g form.This Chinese medicine granules preparation method complexity, is not suitable for individual's operation.
Summary of the invention
For the slightly not enough present situation of existing anti-chemotherapy side effect, one of object of the present invention is to provide a kind of invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, there is the features such as easy to operate, evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost and without any side effects.
Another object of the present invention is just to provide the preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation.
Technical scheme of the present invention is:
The invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from: Radix Paeoniae Alba 5-9 part, Radix Salviae Miltiorrhizae 6-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 part, Poria 6-15 part, Herba Eupatorii 8-15 part, Radix Puerariae 20-35 part, Rhizoma Coptidis 4-12 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Rhizoma Atractylodis 3-7 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
The invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Radix Paeoniae Alba 6-8 part, Radix Salviae Miltiorrhizae 8-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7 part, Poria 8-11 part, Herba Eupatorii 10-13 part, Radix Puerariae 25-30 part, Rhizoma Coptidis 6-10 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Semen Cuscutae 5-7 part, Rhizoma Atractylodis 4-6 part, Fructus Psoraleae (salt is processed) 4-6 part, Radix Clematidis 3-5 part, Pollen Pini 5-7 part.
The invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from: 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The present invention also provides above-mentioned invigorating the spleen and regulating the stomach preparation has been made to pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 65-125 mesh sieve and (preferably, crossed 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably 0.8 part), add the Pollen Pini after step (1) is pulverized, mix, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably 6 parts) and appropriate amount of ethanol, granulation, dry.
The preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferred, 0.5-0.7g/ sheet; Be more preferably 0.6g/ sheet) measure, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.6-1.0g/ grain (preferred, 0.7-0.9g/ grain; Be more preferably 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Paeoniae Alba: nature and flavor: bitter in the mouth, acid, is slightly cold.Gui Jing: return liver, spleen channel.Effect: the joint venture of nourishing blood, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly: blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery is had loose bowels, and has a headache dizzy.
Radix Salviae Miltiorrhizae: nature and flavor: bitter in the mouth, is slightly cold.Gui Jing: GUIXIN, pericardium, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, removing heat from blood eliminating carbuncle.Cure mainly: menoxenia, dysmenorrhea, amenorrhea, the stomachache of being retarded by silt puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, heat enters nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor: bitter in the mouth, sweet, puckery, is slightly cold.Gui Jing: return lung, kidney channel.Effect: astringing to arrest bleeding, detumescence and promoting granulation.Cure mainly: spitting of blood, to spit blood, epistaxis, has blood in stool, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.
Poria: nature and flavor: sweet in the mouth, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Eupatorii: nature and flavor: acrid in the mouth is flat.Gui Jing: return spleen, stomach warp.Effect: expelling summer-heat and damp, be amusing and in.Cure mainly: heat-damp in summer or hygropyrexia from the beginning of, generate heat nose heave, abdominal distention uncomfortable in chest, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, mouthful in sweet greasy, quench one's thirst.
Radix Puerariae: nature and flavor: sweet in the mouth, pungent is flat.Gui Jing: return spleen, stomach warp.Effect: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly: typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.
Rhizoma Coptidis: nature and flavor: bitter in the mouth, cold.Gui Jing: GUIXIN, liver, stomach, large intestine channel.Effect: clearing away heat-fire, dampness, removing toxic substances.Cure mainly: calentura heresy enters the high heat of heart channel, agitation, delirium or the absurd row of intenseness of heat forcing blood tell nosebleed, damp and hot Bears painful abdominal mass is had loose bowels, dysentery, the vexed insomnia of hyperactivity of heart-fire, gastropyretic vomiting, rapid digestion of food and polyorexia, liver-fire conjunctival congestion and swelling pain, and pathopyretic ulcer, furunculosis septicemia, gingival swelling and pain, aphtha of the mouth and tongue, Ting ear, hemorrhoidal bleeding, eczema, scalds.
Herba Artemisiae Anomalae: nature and flavor: bitter in the mouth, temperature.Gui Jing: GUIXIN, lung meridian.Effect: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Cure mainly: amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter in the mouth, sweet, temperature.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Cure mainly: deficiency-weakness of spleen-QI weak, lack of appetite abdominal distention, the constipation of having loose bowels, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement.
Semen Cuscutae: nature and flavor: micro-pungent, sweet, flat.Gui Jing: return liver, kidney channel.Effect: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.Cure mainly: the waist knee joint muscles and bones that is applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Rhizoma Atractylodis: nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return spleen, stomach, Liver Channel.Effect: drying damp and strengthening spleen, wind-damp dispelling, improving eyesight.Cure mainly: the spleen and stomach being stranded by dampness, asthenia drowsiness, feeling of stuffiness in chest abdominal distention, inappetence, vomiting is had loose bowels, phlegm retention, damp-edema, exterior syndrome folder is wet, a heavy sensation of the body pain, arthromyodynia domination of damp pathogen, podomere is ached and is being weighed ， flaccidity of feet with lamenness, nyctalopia.
Fructus Psoraleae (salt is processed): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return kidney, spleen channel.Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.Cure mainly: main insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness, impotence and seminal emission, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency is more than, asthenia of both the spleen and kidney, stool chronic diarrhea, outward for vitiligo, alopecia areata, psoriasis.
Radix Clematidis: nature and flavor: pungent, salty, temperature.Gui Jing: return urinary bladder channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly: gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Pollen Pini: nature and flavor: sweet in the mouth, temperature.Gui Jing: return liver, spleen channel.Effect: the QI invigorating of dispeling the wind, removing dampness, hemostasis.Cure mainly: head revolves dizzy, and middle void has a stomach-ache, chronic dysentery, all skin ulcers are wet rotten, wound hemorrhage.
Invigorating the spleen and regulating the stomach preparation of the present invention is to make on the basis of having studied amount of literature data and clinical trial, has effect of invigorating the spleen and regulating the stomach, and the side reaction causing for chemotherapy has good therapeutic effect.And the medical material of selecting is Chinese medicine material, determined curative effect and without any side effects.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
embodiment 1the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from (getting 10g for every part): 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation powder is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed.
Powder instructions of taking of the present invention: divide 8g/ bag by powder, adopt every day 2-3 time, each one bag, use warm boiled water, 7 days courses for the treatment of.
model case oneyellow XX, the age: 80 years old, sex: female.Patient finds the increase of carrying out property of abdominal swelling thing in August, 2006, bilateral in May, 2007 thoracic cavity and seroperitoneum, and ascites finds adenocarcinoma cell, primary tumor is not quite clear, in June, 2007, emergency hospitalization required to put immediately ascites because of huge Abdominal mass companion severe ascites, after treat by chemotherapy.Chemotherapy causes the malaise symptoms such as weakness of the spleen and stomach, nausea and vomiting, dry mouth and tougue, health be tired.Take the present embodiment gained invigorating the spleen and regulating the stomach preparation powder, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patient's dry mouth and tougue symptom alleviates, and malaise symptoms is alleviated to some extent; Take 2 months, patient's malaise symptoms fades away, and spirit, muscle power strengthen; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 2the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from (getting 20g for every part): 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation unguentum is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 6-10g, takes 7 days courses for the treatment of according to the ratio bath of 1:10.
model case twoold XX, the age: 48 years old, sex: man.Patient's abdominal circumference 103cm, abdominal part has touched multiple things as swollen greatly in fist, and rectal sinuses touches transfer lump as large in egg.One's belly is tight as a drum, become thin, adenocarcinoma cell is found in weak, tachypnea, general pain ascites.Regularly accept chemotherapy and treat, but chemotherapy causes that taste discomfort, health are weak, inappetence with phenomenons such as nausea and vomiting, takes the medicine of anti-chemotherapy side effect, without positive effect, patient becomes thin extremely now.Take the present embodiment gained invigorating the spleen and regulating the stomach preparation unguentum, adopt every day 2 times, each 10g, takes 7 days courses for the treatment of according to the ratio bath of 1:10.Take 14 days, patient's malaise symptoms alleviates, and the food of receiving is gradually many; Take 1 month, patients ' vomiting alleviates, and muscle power strengthens, and malaise symptoms fades away; Continue to take the recovery from illness of patient's self-induction 2 months.
embodiment 3the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from (every part of 30g): 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation granules agent is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) 0.8 part of qinghuo reagent, adds the Pollen Pini after step (1) is pulverized, mixes, and with 6 parts of sucrose and appropriate amount of ethanol, granulation, dry.
Granule instructions of taking of the present invention: divide 10g/ bag by granule, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case threewu XX, the age: 45 years old, sex: female.Patient carries out right side defeated flexible pipe papillary adenocarcinoma excision in August, 2006, and carcinoma is invaded uterus, rectum, carries out a cycle chemotherapy and has produced serious side reaction: weakness of the spleen and stomach, appetite are low, drowsiness, nausea and vomiting, lassitude etc.Take the agent of the present embodiment gained invigorating the spleen and regulating the stomach preparation granules, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of.Take 1 month, patient's appetite strengthens, and malaise symptoms improves gradually; Take 2 months, patient's muscle power strengthens, and the mental status is clearly better, and malaise symptoms fades away; Continue to take 2 months, malaise symptoms disappears.
embodiment 4the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from (every part of 40g): 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation tablet is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to powder;
(4) step (3) gained powder is measured according to 0.6g/ sheet, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets method of the present invention: tablet adopts every day 3 times, each 5-8 sheet, with warm boiled water, 7 days courses for the treatment of.
model case fourlee XX, the age: 68 years old, sex: man.In February, 2008 stomach discomfort, certainly touching epigastrium has the swollen greatly thing of egg, gastroscopy pathology confirms malignant lymphoma, additional regular chemotherapy is received treatment, chemotherapy causes following side reaction :the malaise symptoms such as dry mouth and tougue, taste discomfort, lassitude, health are tired.Take the present embodiment gained invigorating the spleen and regulating the stomach preparation tablet, inferior to every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 10 days, dry mouth and tougue alleviates, and malaise symptoms is alleviated; Take 1 month, patient's appetite strengthens, and the mental status is improved, and malaise symptoms fades away; Continue to take 2 months, patient's malaise symptoms disappears completely.
embodiment 5the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from (every part of 50g): 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation capsule is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain to powder;
(4) step (3) gained powder is measured according to 0.8g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 4-6 grain, with warm boiled water, 7 days courses for the treatment of.
model case fiveking XX, the age: 53 years old, sex: man.Within 2007, suffer from Esophageal Middle Segment malignant tumor, accept chemotherapy in hospital, after chemotherapy, occur the symptoms such as acroanesthesia, nausea and vomiting, inappetence, health be tired, ate the medicine of many anti-chemotherapy side effects, all without positive effect.Take this enforcement gained invigorating the spleen and regulating the stomach preparation capsule, adopt every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 15 days, patient's appetite strengthens to some extent, and nausea and vomiting alleviates; Take 1 month, malaise symptoms is clearly better, and muscle power strengthens; Continue to take 2 months, patient's readme malaise symptoms disappears.
embodiment 6the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, takes off the primary raw material of stating weight proportion and is prepared from (every part of 60g): 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
The preparation method of above-mentioned invigorating the spleen and regulating the stomach preparation water preparation is:
(1) Pollen Pini is pulverized, crossed 120 mesh sieves;
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, (water consumption is 3 times of crude drug gross weight) decoction 3 times adds water, 2 hours for the first time, 0.8 hour for the second time, 0.8 hour for the third time, three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.
test example 1the clinical practice of embodiment 6 gained invigorating the spleen and regulating the stomach preparation water preparations: in October, 2008-2012 year March, screen 200 routine patients in 8 hospitals, wherein women's 106 examples, male's 94 examples.Test 3 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 6 products obtained therefroms, and matched group is taken other medicine (the conventional medicine such as safe peace oral liquid, holy liquid oral liquid, selenium Wei Kang).Using method is: take every day twice (warm), each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 6 products obtained therefrom therapeutic effect checkings
Experimental group Matched group
Number of cases 100 100
Male's number of cases 46 48
Women's number of cases 54 52
Clinical cure number of cases 71 20
Effectively number of cases 28 52
Invalid number of cases 1 28
Total effective rate 99% 72%
Therapeutic effect: cure 71 examples (71%), effective 28 examples (28%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
As shown in Table 2: take 10 days, more than 54% patients ' vomiting alleviates, malaise symptoms takes a turn for the better to some extent; Take 20 days, more than 73% patient feels to take a turn for the better to some extent, and weakness of the spleen and stomach symptom is improved, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 95% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, the recovery from illness of some patients were self-induction.In experimental group, take more than 30 days, effective percentage can reach 95%, and matched group is only 75%.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.

Claims (10)

1. the invigorating the spleen and regulating the stomach preparation of anti-chemotherapy side effect, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Paeoniae Alba 5-9 part, Radix Salviae Miltiorrhizae 6-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 part, Poria 6-15 part, Herba Eupatorii 8-15 part, Radix Puerariae 20-35 part, Rhizoma Coptidis 4-12 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Atractylodis Macrocephalae 4-9 part, Semen Cuscutae 3-9 part, Rhizoma Atractylodis 3-7 part, Fructus Psoraleae (salt is processed) 2-8 part, Radix Clematidis 2-6 part, Pollen Pini 3-8 part.
2. invigorating the spleen and regulating the stomach preparation according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Radix Paeoniae Alba 6-8 part, Radix Salviae Miltiorrhizae 8-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7 part, Poria 8-11 part, Herba Eupatorii 10-13 part, Radix Puerariae 25-30 part, Rhizoma Coptidis 6-10 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Atractylodis Macrocephalae 5-8 part, Semen Cuscutae 5-7 part, Rhizoma Atractylodis 4-6 part, Fructus Psoraleae (salt is processed) 4-6 part, Radix Clematidis 3-5 part, Pollen Pini 5-7 part.
3. invigorating the spleen and regulating the stomach preparation according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 7 parts of the Radix Paeoniae Albas, 9 parts of Radix Salviae Miltiorrhizaes, 6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts, Poria, 11 parts of Herba Eupatoriis, 28 parts of Radix Puerariaes, 8 parts of Rhizoma Coptidis, 10 parts of Herba Artemisiae Anomalaes, 7 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Semen Cuscutae, 5 parts of Rhizoma Atractylodis, 5 parts of Fructus Psoraleaes (salt is processed), 4 parts of Radix Clematidis, 6 parts of Pollen Pinis.
4. according to the arbitrary described invigorating the spleen and regulating the stomach preparation of claim 1-3, it is characterized in that, said preparation is made to pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
5. invigorating the spleen and regulating the stomach preparation according to claim 4, is characterized in that, the preparation method of described powder is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis co-grinding are crossed to 65-125 mesh sieve and (preferably, crossed 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
6. invigorating the spleen and regulating the stomach preparation according to claim 4, is characterized in that, the preparation method of described water preparation is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) Pollen Pini after step (1) pulverizing is added to step (2) gained medicinal liquid, sterile packaged.
7. invigorating the spleen and regulating the stomach preparation according to claim 4, is characterized in that, the preparation method of described unguentum is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) pulverizing is added to step (3) gained clear paste, sterile packaged.
8. invigorating the spleen and regulating the stomach preparation according to claim 4, is characterized in that, the preparation method of described granule is:
(1) Pollen Pini is pulverized, crossed 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Herba Eupatorii, Radix Puerariae, Rhizoma Coptidis, Herba Artemisiae Anomalae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Rhizoma Atractylodis, Fructus Psoraleae (salt is processed) and Radix Clematidis are placed in marmite, adding water, (water consumption is 2-4 times (preferably, 2.5-3.5 times of crude drug gross weight; Be more preferably 3 times)) decoct 1.5-2.5 hour for the first time (preferred 1.8-2.2 hour 3 times; Be more preferably 2 hours), 0.5-1.2 hour for the second time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), 0.5-1.2 hour for the third time (preferred, 0.7-1.0 hour; Be more preferably 0.8 hour), three gained filtrates are merged, leave standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 ℃) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably 0.8 part), add the Pollen Pini after step (1) is pulverized, mix, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably 6 parts) and appropriate amount of ethanol, granulation, dry.
9. invigorating the spleen and regulating the stomach preparation according to claim 4, is characterized in that, the preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferred, 0.5-0.7g/ sheet; Be more preferably 0.6g/ sheet) measure, be pressed into the lamellar dosage form of circle or other shapes according to the preparation for processing of tablet.
10. invigorating the spleen and regulating the stomach preparation according to claim 4, is characterized in that, the preparation method of described capsule is: by claim 5 gained powder according to 0.6-1.0g/ grain (preferred, 0.7-0.9g/ grain; Be more preferably 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
CN201410144867.4A 2014-04-12 2014-04-12 Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof Pending CN103908579A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN201510904009.XA CN105434862A (en) 2014-04-12 2014-04-12 Spleen-and-stomach strengthening powder for resisting side effects of chemotherapy
CN201510904258.9A CN105395870A (en) 2014-04-12 2014-04-12 Spleen invigorating and stomach harmonizing drug resisting chemotherapy side reaction
CN201410144867.4A CN103908579A (en) 2014-04-12 2014-04-12 Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof
CN201510904259.3A CN105412599A (en) 2014-04-12 2014-04-12 Preparation tablet capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904383.XA CN105412600A (en) 2014-04-12 2014-04-12 Preparation capsule capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904486.6A CN105395872A (en) 2014-04-12 2014-04-12 Spleen strengthening and stomach harmonizing oral liquid for resisting chemotherapy side reaction
CN201510904490.2A CN105434863A (en) 2014-04-12 2014-04-12 Spleen-and-stomach preparation granules for resisting side effects of chemotherapy
CN201510904350.5A CN105395871A (en) 2014-04-12 2014-04-12 Oral liquid resisting chemotherapy side reaction
CN201510904239.6A CN105477336A (en) 2014-04-12 2014-04-12 Spleen-strengthening stomach-harmonizing ointment resistant to side effects of chemotherapy
CN201510904489.XA CN105412601A (en) 2014-04-12 2014-04-12 Oral liquid used for resisting chemotherapy side reactions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410144867.4A CN103908579A (en) 2014-04-12 2014-04-12 Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof

Related Child Applications (9)

Application Number Title Priority Date Filing Date
CN201510904383.XA Division CN105412600A (en) 2014-04-12 2014-04-12 Preparation capsule capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904259.3A Division CN105412599A (en) 2014-04-12 2014-04-12 Preparation tablet capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904350.5A Division CN105395871A (en) 2014-04-12 2014-04-12 Oral liquid resisting chemotherapy side reaction
CN201510904490.2A Division CN105434863A (en) 2014-04-12 2014-04-12 Spleen-and-stomach preparation granules for resisting side effects of chemotherapy
CN201510904489.XA Division CN105412601A (en) 2014-04-12 2014-04-12 Oral liquid used for resisting chemotherapy side reactions
CN201510904486.6A Division CN105395872A (en) 2014-04-12 2014-04-12 Spleen strengthening and stomach harmonizing oral liquid for resisting chemotherapy side reaction
CN201510904258.9A Division CN105395870A (en) 2014-04-12 2014-04-12 Spleen invigorating and stomach harmonizing drug resisting chemotherapy side reaction
CN201510904009.XA Division CN105434862A (en) 2014-04-12 2014-04-12 Spleen-and-stomach strengthening powder for resisting side effects of chemotherapy
CN201510904239.6A Division CN105477336A (en) 2014-04-12 2014-04-12 Spleen-strengthening stomach-harmonizing ointment resistant to side effects of chemotherapy

Publications (1)

Publication Number Publication Date
CN103908579A true CN103908579A (en) 2014-07-09

Family

ID=51034783

Family Applications (10)

Application Number Title Priority Date Filing Date
CN201510904259.3A Withdrawn CN105412599A (en) 2014-04-12 2014-04-12 Preparation tablet capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904350.5A Withdrawn CN105395871A (en) 2014-04-12 2014-04-12 Oral liquid resisting chemotherapy side reaction
CN201510904489.XA Withdrawn CN105412601A (en) 2014-04-12 2014-04-12 Oral liquid used for resisting chemotherapy side reactions
CN201510904486.6A Withdrawn CN105395872A (en) 2014-04-12 2014-04-12 Spleen strengthening and stomach harmonizing oral liquid for resisting chemotherapy side reaction
CN201510904490.2A Withdrawn CN105434863A (en) 2014-04-12 2014-04-12 Spleen-and-stomach preparation granules for resisting side effects of chemotherapy
CN201410144867.4A Pending CN103908579A (en) 2014-04-12 2014-04-12 Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof
CN201510904383.XA Withdrawn CN105412600A (en) 2014-04-12 2014-04-12 Preparation capsule capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904009.XA Withdrawn CN105434862A (en) 2014-04-12 2014-04-12 Spleen-and-stomach strengthening powder for resisting side effects of chemotherapy
CN201510904239.6A Withdrawn CN105477336A (en) 2014-04-12 2014-04-12 Spleen-strengthening stomach-harmonizing ointment resistant to side effects of chemotherapy
CN201510904258.9A Withdrawn CN105395870A (en) 2014-04-12 2014-04-12 Spleen invigorating and stomach harmonizing drug resisting chemotherapy side reaction

Family Applications Before (5)

Application Number Title Priority Date Filing Date
CN201510904259.3A Withdrawn CN105412599A (en) 2014-04-12 2014-04-12 Preparation tablet capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904350.5A Withdrawn CN105395871A (en) 2014-04-12 2014-04-12 Oral liquid resisting chemotherapy side reaction
CN201510904489.XA Withdrawn CN105412601A (en) 2014-04-12 2014-04-12 Oral liquid used for resisting chemotherapy side reactions
CN201510904486.6A Withdrawn CN105395872A (en) 2014-04-12 2014-04-12 Spleen strengthening and stomach harmonizing oral liquid for resisting chemotherapy side reaction
CN201510904490.2A Withdrawn CN105434863A (en) 2014-04-12 2014-04-12 Spleen-and-stomach preparation granules for resisting side effects of chemotherapy

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201510904383.XA Withdrawn CN105412600A (en) 2014-04-12 2014-04-12 Preparation capsule capable of resisting chemical therapy side effects and strengthening spleen and stomach
CN201510904009.XA Withdrawn CN105434862A (en) 2014-04-12 2014-04-12 Spleen-and-stomach strengthening powder for resisting side effects of chemotherapy
CN201510904239.6A Withdrawn CN105477336A (en) 2014-04-12 2014-04-12 Spleen-strengthening stomach-harmonizing ointment resistant to side effects of chemotherapy
CN201510904258.9A Withdrawn CN105395870A (en) 2014-04-12 2014-04-12 Spleen invigorating and stomach harmonizing drug resisting chemotherapy side reaction

Country Status (1)

Country Link
CN (10) CN105412599A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491182A (en) * 2015-01-08 2015-04-08 李宏 Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101675989A (en) * 2008-09-18 2010-03-24 天津市中宝制药有限公司 Qi-supplementing, spleen-invigorating, kidney-tonifying and blood-generating traditional Chinese medicine composition
CN102302630A (en) * 2011-09-05 2012-01-04 黎淦森 Chinese patent medicine used for increasing leucocytes and enhancing immunity
CN102614442A (en) * 2012-01-01 2012-08-01 徐永波 Traditional Chinese drug capsules with effects of immunity enhancing, blood reinforcing and antiemesis
CN103536638A (en) * 2013-10-22 2014-01-29 第三军医大学第二附属医院 Medicament for treating gastrointestinal dysfunction and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101675989A (en) * 2008-09-18 2010-03-24 天津市中宝制药有限公司 Qi-supplementing, spleen-invigorating, kidney-tonifying and blood-generating traditional Chinese medicine composition
CN102302630A (en) * 2011-09-05 2012-01-04 黎淦森 Chinese patent medicine used for increasing leucocytes and enhancing immunity
CN102614442A (en) * 2012-01-01 2012-08-01 徐永波 Traditional Chinese drug capsules with effects of immunity enhancing, blood reinforcing and antiemesis
CN103536638A (en) * 2013-10-22 2014-01-29 第三军医大学第二附属医院 Medicament for treating gastrointestinal dysfunction and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
何耿劲: "益气健脾养阴方联合化疗治疗中晚期胃癌的临床疗效及体会", 《辽宁中医杂志》 *
杨宝印编著: "《癌症的中药治疗》", 28 February 1992 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491182A (en) * 2015-01-08 2015-04-08 李宏 Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method

Also Published As

Publication number Publication date
CN105434863A (en) 2016-03-30
CN105395872A (en) 2016-03-16
CN105434862A (en) 2016-03-30
CN105395871A (en) 2016-03-16
CN105412600A (en) 2016-03-23
CN105477336A (en) 2016-04-13
CN105412599A (en) 2016-03-23
CN105395870A (en) 2016-03-16
CN105412601A (en) 2016-03-23

Similar Documents

Publication Publication Date Title
CN103920034A (en) Traditional Chinese medicine composition for alleviating side effects of chemotherapy of cancer patient and preparation method traditional Chinese medicine composition
CN101607011B (en) Traditional Chinese medicine for treating cholecystitis post-operative complacation
CN105213974A (en) One treats lymphadenomatous Chinese medicine composition and application thereof
CN103690889A (en) Traditional Chinese medicine decoction for treating stomach cancer
CN104042981A (en) Medicament for treating postnatal constipation and preparation method thereof
CN103908616B (en) The medicament of tumor remission patient radiotherapy side effect and preparation method
CN103495103B (en) Medicament for promoting digestion and strengthening spleen
CN103908579A (en) Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof
CN103908495B (en) Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function
CN103908520A (en) Spleen-invigorating and kidney-nourishing preparation for relieving postoperative radiotherapy reaction of tumor patients and preparation method thereof
CN103919995A (en) Medicine for resisting side effects of postoperative cancer patients and preparation method
CN103585518A (en) Traditional Chinese medicinal preparation for treating lichen urticatus
CN102552619A (en) Medicine for treating tumor and preparation method thereof
CN105748911A (en) Side reaction resisting capsule for postoperative tumor patients and preparation method thereof
CN102416059B (en) Medicinal composition for treating colon cancer
CN105125817A (en) Preparation for treating abdominal distension and preparation method of preparation
CN104436053A (en) Traditional Chinese medicine composition for treating gastric body cancer
CN104825888A (en) Traditional Chinese medicine composition for treating intractable insomnia and preparation method thereof
CN103495104A (en) Medicament for promoting digestion and strengthening spleen
CN105641424A (en) Postoperative tumor patient side-effect-resistant granules
CN105641423A (en) Postoperative tumor patient side-effect-resistant tablets
CN104473983A (en) Health-care rice wine
CN104288692A (en) Traditional Chinese medicine decoction for treating hepatapostema
CN103479954A (en) Preparation method for digestion-helping spleen-tonifying medicines
CN102579764A (en) Traditional Chinese medicine for preventing and curing recurrent aphthae and preparing method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: Qujing City, Yunnan Province, 655000 West Road No. 6 Xiyuan District Feng kylin District 2-2-601

Applicant after: Chen Xin

Address before: 250014 Shandong City, Ji'nan province area of the liberation of East Road, No. 34, No. 5 modern Yi Building, unit 1001, 2

Applicant before: Chen Xin

COR Change of bibliographic data
RJ01 Rejection of invention patent application after publication

Application publication date: 20140709

RJ01 Rejection of invention patent application after publication