CN103908495B - Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function - Google Patents
Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition improving tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 8-16 part, Radix Cyathulae 3-12 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Thallus Laminariae (Thallus Eckloniae) 6-14 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Chuanxiong 6-15 part, Poria 6-12 part, Herba Centellae 3-6 part, Fructus Psoraleae (salt is processed) 2-8 part, Fructus Toosendan 3-9 part, Pollen Pini 5-9 part.Chinese medicine composition determined curative effect of the present invention and without any side effects, can improve the immunologic function of patient.
Description
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of Chinese medicine composition and the method for making that improve tumor patient Postoperative Immunity function.
Background technology
Tumor, especially malignant tumor have a strong impact on the life and health of people, for malignant tumor, generally adopt operative treatment, radiation treatment and chemotherapy.Radiotherapy is the roentgenization tumor with various different-energy, to suppress and to kill a kind of Therapeutic Method of cancerous cell.Chemotherapy, be treat malignant tumor by chemical substance, chemotherapeutics, with Formulations for systemic administration, can be attacked all cells of health, and be not only cancerous cell.Some chemotherapeutics are utilized separately for Therapeutic cancer, but several drugs therapeutic alliance often.
Because chemotherapy utilizes chemicals to kill tumor cell, the growth and breeding of inhibition tumor cell and the differentiation of promotion tumor cell, heavy dose of chemicals is while killing tumor cell, also normal cell and immunity (opposing) cell together being killed, is the Therapeutic Method of a kind of " destruction of all people good and bad alike ".Radiotherapy chemotherapy is while treatment tumor, and the side effect that also can produce human body, reduces the immunity of human body.These toxic and side effects main manifestations are, nausea and vomiting, alopecia, inappetence, headache and myalgia, malaise, bone marrow depression, anemia, thrombocytopenia, injury of lung, reproductive system damage, kidney and urinary injuries, liver dysfunction etc.These side effect have had a strong impact on the therapeutic effect of Radiotherapy chemotherapy, are even forced to stop treatment.
Malignant tumor belongs to that the traditional Chinese medical science " is amassed ", the category of " asthenia ", there is the performance of vital QI being weakened and pathogen being violent.And due to being continuous of the course of disease, the phenomenon of " the kidney usually involved in chronic disease " can be caused.After accepting Radiotherapy chemotherapy, disease that it is weakened body resistance is more obvious, causes because vigour is impaired further: lethargy, malaise, dysphoria with feverish sensation in the chest palms and soles, say lazy language etc. less.Hinder and then feel sick indigestion and loss of appetite in stomach, hinder in kidney then dizziness and tinnitus, dedentition loss of hairs, soreness of waist foot is soft, hinders in the heart then shortness of breath and palpitation.Therefore, alleviate the toxic and side effects of Radiotherapy chemotherapy, improve the immunity of patient, make patient better can accept treatment, tool has very important significance.
Chinese medicine has obvious advantage in the immunity improving these reactions, raising patient, but the new drug be really developed to not is a lot.Chinese medicine composition of the present invention is consulting on the basis of a large amount of TCM Document data and a large amount of clinical trial, the main hypertensive TCM pathogenesis of the toxicity produced for Radiotherapy chemotherapy and reduction patient immunity, while the toxicity that treatment is long-living by Radiotherapy chemotherapy, the immunity of patient can also be improved, strengthen the body constitution of patient, enable patient better accept treatment, avoid producing the phenomenon stopping because of the side reaction of Radiotherapy chemotherapy treating.
Application publication number is CN103272116A(application number 201310197270.1) Chinese patent literature disclose a kind of by name " medicine for radiation period adjustment body immunity ", this medicine is by the Radix Astragali 40 ~ 60, Radix Angelicae Sinensis 5 ~ 15, Radix Ophiopogonis 10 ~ 30, Radix Panacis Quinquefolii 1 ~ 3, Fructus Corni 5 ~ 15, Fructus Lycii 5 ~ 15, Radix Scrophulariae 5 ~ 15, Flos Chrysanthemi 5 ~ 10, Flos Carthami 5 ~ 10, monkey mushroom bacterium 30 ~ 60, Radix Actinidiae Chinensis 30 ~ 60, Fructificatio Amaurodermatis Rudae 10 ~ 15, Semen Cuscutae 15 ~ 25, Fructus Psoraleae 5 ~ 15, Fructus Ligustri Lucidi 15 ~ 25, Herba Ecliptae 15 ~ 25, Rhizoma Atractylodis Macrocephalae (parched) 15 ~ 25, Rhizoma Dioscoreae 15 ~ 25 forms.Application publication number is CN101926429A(application number 201010239490.2) Chinese patent literature disclose a kind of by name " nutritional solution and the preparation method of chemotherapeutic period immunity can be strengthened ", this nutritional solution is be the Carnis Haliotidis polysaccharide of 2%-20% and the mixed solution of fucoidan by solid content, according to Carnis Haliotidis polysaccharide 5-50mg/100ml, the proportioning mixing of fucoidan 100-1000mg/100ml, and in mixed solution, to add Pericarpium Citri Reticulatae boil and make.Application publication number is CN102327390A(application number 201110314905.2) Chinese patent literature disclose a kind of by name " a kind of prevent and treat the Chinese prescription of chemotherapy toxic side effect and the preparation method of pill thereof ", it is made up of according to certain weight proportion Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Cistanches, Cornu Cervi Pantotrichum, Moschus, Stalactitum, Radix Morindae Officinalis, Radix Aconiti Lateralis Preparata, Stichopus japonicus, Radix Glycyrrhizae, Colla cornus cervi, yellow wine.
In a word, Chinese medicine achieves certain effect in the side reaction for the treatment of Radiotherapy chemotherapy, but also there are some problems: desirable not enough to the therapeutic effect of the immunity aspect improving patient clinically; Some formula medical materials are numerous, and medical material cost is higher, are not suitable for most people and take, and therefore need perfect further.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide that one is prepared simply, taking convenience, portable Chinese medicine composition, has good therapeutic effect, can improve the immunologic function of patient to the toxicity that Radiotherapy chemotherapy causes.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Technical scheme of the present invention is:
Improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from: Radix Codonopsis 8-16 part, Radix Cyathulae 3-12 part, Fructus Ligustri Lucidi 6-12 part, Poria cum Radix Pini 6-9 part, Thallus Laminariae (Thallus Eckloniae) 6-14 part, Radix Puerariae 20-35 part, Herba Artemisiae Anomalae 6-15 part, Rhizoma Chuanxiong 6-15 part, Poria 6-12 part, Herba Centellae 3-6 part, Fructus Psoraleae (salt is processed) 2-8 part, Fructus Toosendan 3-9 part, Pollen Pini 5-9 part.
Improve the Chinese medicine composition of tumor patient Postoperative Immunity function, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Codonopsis 10-14 part, Radix Cyathulae 5-9 part, Fructus Ligustri Lucidi 8-10 part, Poria cum Radix Pini 6-8 part, Thallus Laminariae (Thallus Eckloniae) 8-12 part, Radix Puerariae 25-30 part, Herba Artemisiae Anomalae 9-12 part, Rhizoma Chuanxiong 9-13 part, Poria 8-10 part, Herba Centellae 3-5 part, Fructus Psoraleae (salt is processed) 4-6 part, Fructus Toosendan 5-7 part, Pollen Pini 6-8 part.
Improve the Chinese medicine composition of tumor patient Postoperative Immunity function, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
Present invention also offers and above-mentioned Chinese medicine composition is made pharmaceutically acceptable powder, water preparation, unguentum, granule, tablet or capsule.
The preparation method of described powder is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed 65-125 mesh sieve and (preferably, cross 80-110 mesh sieve; Be more preferably, cross 95 mesh sieves);
(3) step (1) and (2) gained are mixed.
The preparation method of described water preparation is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) be placed in marmite by Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) Pollen Pini after step (1) being pulverized adds step (2) gained medicinal liquid, sterile packaged.
The preparation method of described unguentum is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) be placed in marmite by Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) being pulverized adds step (3) gained clear paste, sterile packaged.
The preparation method of described granule is:
(1) Pollen Pini is pulverized, cross 100-140 mesh sieve and (preferably, cross 110-130 mesh sieve; Be more preferably, cross 120 mesh sieves);
(2) be placed in marmite by Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan, adding water, (water consumption is that doubly (preferred, 2.5-3.5 doubly for the 2-4 of crude drug gross weight; Be more preferably, 3 times)) decoct 3 times, first time 1.5-2.5 hour (preferred 1.8-2.2 hour; Be more preferably, 2 hours), second time 0.5-1.2 hour (preferably, 0.7-1.0 hour; Be more preferably, 0.8 hour), and 0.5-1.2 hour third time (preferred, 0.7-1.0 hour; Be more preferably, 0.8 hour), three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.5-1.2 part (preferably, 0.7-1.0 part; Be more preferably, 0.8 part), add the Pollen Pini after step (1) pulverizing, mixing, with sucrose 4-7 part (preferably, 5-7 part; Be more preferably, 6 parts) and appropriate amount of ethanol, make granule, dry.
The preparation method of described tablet is: by claim 5 gained powder according to 0.4-0.8g/ sheet (preferably, 0.5-0.7g/ sheet; Be more preferably, 0.6g/ sheet) metering, the tablet dosage form of circle or other shapes is pressed into according to the preparation for processing of tablet.
The preparation method of described capsule is: by claim 5 gained medicament powder according to 0.6-1.0g/ grain (preferably, 0.7-0.9g/ grain; Be more preferably, 0.8g/ grain) metering, be processed into capsule shape dosage form according to the preparation for processing of capsule.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Codonopsis: nature and flavor: property is sweet is flat.Gui Jing: return spleen, lung meridian.Effect: strengthening spleen, tonifying kidney, supplementing QI for promoting the production of body fluid.Cure mainly: weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, spontaneous perspiration of breathing hard, all diseases of deficiency of both QI and blood.
Radix Cyathulae: nature and flavor: sweet in the mouth, bitter in the mouth, flat.Gui Jing: return liver, kidney channel.Effect: promoting blood circulation to remove blood stasis, expelling wind and removing dampness.Cure mainly: blood stasis amenorrhea, difficult labour, retention of placenta, puerperal abdominalgia with blood stasis, pyretic stranguria, stranguria caused by urinary stone, dysmenorrhea, rheumatism lumbocrural pain, traumatic injury.
Fructus Ligustri Lucidi: nature and flavor: taste sweet, bitter, cold.Gui Jing: return liver, kidney channel.Effect: liver and kidney tonifying, clearind deficient heat you, improving eyesight.Cure mainly: Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Poria cum Radix Pini: nature and flavor: sweet in the mouth, light, flat.Gui Jing: GUIXIN, lung meridian.Effect: mind calming, calms the nerves, diuretic.Cure mainly: palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Thallus Laminariae (Thallus Eckloniae): nature and flavor: salty in the mouth, cold.Gui Jing: return liver, stomach, kidney channel.Effect: softening and eliminating sputum, inducing diuresis to remove edema.Cure mainly: goiter, scrofula, swelling of the scrotum, the cancer of the esophagus, beriberi edema.
Radix Puerariae: nature and flavor: sweet in the mouth, pungent is flat.Gui Jing: return spleen, stomach warp.Effect: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure mainly: typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.
Herba Artemisiae Anomalae: nature and flavor: bitter in the mouth, temperature.Gui Jing: GUIXIN, lung meridian.Effect: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Cure mainly: amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
Rhizoma Chuanxiong: nature and flavor: acrid in the mouth, temperature.Gui Jing: return liver, gallbladder pericardium channel.Effect: blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.Cure mainly: menoxenia, amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen lump, pain in chest and hypochondrium, has a headache dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores.
Poria: nature and flavor: sweet in the mouth, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Centellae: nature and flavor: taste bitter, acrid, cold.Gui Jing: return liver,spleen,kidney warp.Effect: heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Be the long-lived medicine of Asians, can refresh oneself by beneficial brain.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.Also effective in cure to leprosy, ulcer, there is activation to blood purification and immunity, because it can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviate mental fatigue; Also can blood pressure lowering, treatment hepatopathy etc.
Fructus Psoraleae (salt is processed): nature and flavor: acrid in the mouth, hardship, temperature.Gui Jing: return kidney, spleen channel.Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha.Cure mainly: main insufficiency of kidney-YANG, below element deficiency and cold, chills and pain of the waist and kness, impotence and seminal emission, frequent micturition, the enuresis, failure of the kidney in receiving QI, dyspnea due to deficiency is more than, asthenia of both the spleen and kidney, stool chronic diarrhea, outward for vitiligo, and alopecia areata, psoriasis.Fructus Toosendan: nature and flavor: bitter in the mouth, cold; Slightly poisonous.Gui Jing: return liver, small intestinal, urinary bladder channel.Effect: soothing the liver promoting the circulation of QI to relieve pain, anthelmintic.Cure mainly: for the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Pollen Pini: nature and flavor: sweet in the mouth, temperature.Gui Jing: return liver, spleen channel.Effect: QI invigorating of dispeling the wind, removing dampness, hemostasis.Cure mainly: head revolves dizzy, middle void has a stomach-ache, chronic dysentery, and all skin ulcers wet rotten, wound hemorrhage.
Chinese medicine composition scientific formula provided by the invention, the preparation method of various dosage form is simple, makes products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1. this prescription meets the body and mind feature of Chinese medicine principle and tumour patient completely, effectively can improve tumor patient Postoperative Immunity function.
2. selected materials is all Chinese medicine material, without any side effects.
3. medicine source is easy to get, and medical material is with low cost, the financial burden of energy ameliorate tumor patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
The preparation method of above-mentioned Chinese medicine powder is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed 95 mesh sieves;
(3) step (1) and (2) gained are mixed.
Powder instructions of taking of the present invention: powder is divided 10g/ bag, adopts every day 2-3 time, each one bag, with warm boiled water, and 7 days courses for the treatment of.
model case onebeam XX, age: 46 years old, sex: man.Suffer from the two metastasic cervical lymph nodes of rhinitis scale cancer in June, 2006, regularly treated by Radiotherapy chemotherapy.Radiotherapy chemotherapy causes some toxicities: immunologic function degression, nausea and vomiting, inappetence, dry mouth and tougue, malaise etc.Take the present embodiment gained Chinese medicine powder, adopt every day 3 times, each one bag, with warm boiled water, 7 days courses for the treatment of.Take 10 days, patient's dry mouth and tougue symptom alleviates, and appetite is cumulative; Take 1 month, patient's malaise symptoms fades away, and immunologic function improves; Continue to take 2 months, patient's self-induction is without malaise symptoms.
embodiment 2improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from (getting 20g for every part): Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
The preparation method of above-mentioned Traditional Chinese medicine composition paste is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, add water (water consumption is 3 times of crude drug gross weight) decoction 3 times, 2 hours first times, second time 0.8 hour, 0.8 hour third time, three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) Pollen Pini after step (1) being pulverized adds step (3) gained clear paste, sterile packaged.
Unguentum instructions of taking of the present invention: unguentum adopts every day 2 times, each 6-12g, takes according to the ratio bath of 1:10,7 days courses for the treatment of.
model case twopan XX, age: 58 years old, sex: man.Patient is because suffering from the low differentiated squamous-cell carcinomas of nasopharynx part, and in March, 2008 starts chemotherapy, occurs heating, xerostomia after chemotherapy, and weak weak, appetite is low, and the malaise symptoms such as immunity degradation, exception of now becoming thin, takes anti-chemotherapy side effect medicine, all ineffective.Take the present embodiment gained Traditional Chinese medicine composition paste, adopt every day 2 times, each 10g, take according to the ratio bath of 1:10,7 days courses for the treatment of.Take 14 days, patient's malaise symptoms alleviates; Take 2 months, patient's immunity strengthens, and muscle power strengthens, and malaise symptoms fades away; Continue to take 2 months, patient's self-induction is fully recovered.
embodiment 3improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from (every part of 30g): Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
The preparation method of above-mentioned Chinese medicinal composition granules is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, add water (water consumption is 3 times of crude drug gross weight) decoction 3 times, 2 hours first times, second time 0.8 hour, 0.8 hour third time, three gained filtrates are merged, leaves standstill, filter;
(3) step (2) gained filtrate being concentrated into relative density is 1.05-1.50(50 DEG C) clear paste, be cooled to room temperature;
(4) qinghuo reagent 0.8 part, add the Pollen Pini after step (1) pulverizing, mixing, with sucrose 6 parts and appropriate amount of ethanol, makes granule, dry.
Granule instructions of taking of the present invention: granule is divided 8g/ bag, every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
model case threewu XX, age: 52 years old, sex: female.Patient's in January, 2007 left newborn infiltrating duct carcinoma radical correction, axillary lymph is carried down and is moved, and postoperatively carries out chemotherapy two cycle and does radiotherapy again.Occur after Radiotherapy chemotherapy pale complexion, dizzy weak, become thin, immunity degradation, nausea and vomiting, without malaise symptoms such as appetite.Take the present embodiment gained Chinese medicinal composition granules, adopt every day 3 times, each 1 one bags, with warm boiled water, 7 days courses for the treatment of.Take 21 days, patient's appetite strengthens, and malaise symptoms improves gradually; Take 2 months, patient's immunity improves, and the mental status is clearly better, and malaise symptoms fades away; Continue to take 2 months, malaise symptoms disappears completely.
embodiment 4improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from (every part of 40g): Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
The preparation method of above-mentioned Chinese medicine composition tablet is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.6g/ sheet, be pressed into the tablet dosage form of circle or other shapes according to the preparation for processing of tablet.
Tablets instructions of taking: tablet adopts every day 3 times, each 6-10 sheet, with warm boiled water, 7 days courses for the treatment of.
model case fourwu XX, age: 55 years old, sex: female.In April, 2009 finds right tonsil malignant lymphoma, through chemotherapy, radiotherapy, swollen thing disappears, in July, 2010 grows multiple swollen thing as large in Ovum Columba livia-egg again in right groin, right neck, left oxter, row chemotherapy is alleviated to some extent again, but Radiotherapy chemotherapy causes symptoms such as health is tired, drowsiness, night sweat, lassitude, weakness of the spleen and stomach.Take the present embodiment gained Chinese medicine composition tablet, secondary to every day 3 times, each 8, with warm boiled water, 7 days courses for the treatment of.Take 15 days, night sweat, drowsiness symptom alleviate, and malaise symptoms is alleviated; Take 1 month, patient's appetite strengthens, and the mental status is improved, and malaise symptoms fades away; Continue to take 2 months, patient's malaise symptoms disappears completely.
embodiment 5improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from (every part of 50g): Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
The preparation method of above-mentioned Chinese medicinal composition capsules agent is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan co-grinding are crossed 95 mesh sieves;
(3) step (1) and (2) gained are mixed to obtain powder;
(4) step (3) gained powder is measured according to 0.8g/ grain, be processed into capsule shape dosage form according to the preparation for processing of capsule.
Capsule instructions of taking of the present invention: capsule adopts every day 3 times, each 5-8 grain, with warm boiled water, 7 days courses for the treatment of.
model case fiveliu XX, age: 63 years old, sex: man.Within 2008, suffer from malignant tumor of esophagus, accept chemotherapy in hospital, occur the symptoms such as acroanesthesia, nausea and vomiting, xerosis cutis, inappetence, health be tired after chemotherapy, ate the medicine of many anti-chemotherapy side effects, all without positive effect.Take the agent of this enforcement Chinese medicinal composition capsules, adopt every day 3 times, each 6, with warm boiled water, 7 days courses for the treatment of.Take 7 days, patient's appetite strengthens to some extent, and nausea and vomiting symptom alleviates; Take 1 month, malaise symptoms is clearly better, and muscle power strengthens; Continue to take 2 months, immunity strengthens, and patient's readme malaise symptoms disappears.
embodiment 6improve the Chinese medicine composition of tumor patient Postoperative Immunity function, take off the primary raw material stating weight proportion and be prepared from (every part of 60g): Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, Fructus Psoraleae (salt is processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts.
The preparation method of above-mentioned Chinese medicine composition water preparation is:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, Fructus Psoraleae (salt is processed) and Fructus Toosendan are placed in marmite, add water (water consumption is 3 times of crude drug gross weight) decoction 3 times, 2 hours first times, second time 0.8 hour, 0.8 hour third time, three gained filtrates are merged, leaves standstill, filter;
(3) Pollen Pini after step (1) being pulverized adds step (2) gained medicinal liquid, sterile packaged.
Water preparation instructions of taking of the present invention: water preparation adopts every day 2 times (warm), each 300-500ml, 7 days courses for the treatment of.
test example 1the clinical practice of embodiment 6 gained Chinese medicine composition water preparation: in April ,-2012 in May, 2009, screen 100 routine patients in 6 hospitals, wherein women 43 example, male 57 example.Before test 2 weeks, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups at random, experimental group and matched group, experimental group takes embodiment 6 products obtained therefrom, and matched group takes other medicine (conventional medication such as safe peace oral liquid, holy liquid oral liquid).Using method is: daily twice (warm), and each 300m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, malaise symptoms alleviates or partial disappearance, energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take the checking of embodiment 6 products obtained therefrom therapeutic effect
| Experimental group | Matched group | |
| Number of cases | 50 | 50 |
| Male's number of cases | 30 | 27 |
| Women's number of cases | 20 | 23 |
| Clinical cure number of cases | 35 | 11 |
| Effective number of cases | 14 | 24 |
| Invalid number of cases | 1 | 15 |
| Total effective rate | 98% | 72% |
Therapeutic effect: cure 35 examples (70%), effective 14 examples (28%), invalid 1 example (2%), total effective rate 98%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
The present invention selects Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae) etc. to carry out compatibility, makes medicine produce synergism, and the side reaction of energy more effective treatment Radiotherapy chemotherapy, improves the immunity of patient.Take 20 days, patient's immunity of more than 53% strengthens, malaise symptoms takes a turn for the better to some extent; Take 40 days, the patient of more than 74% feels to take a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 60 days, more than 95% feel takes a turn for the better to some extent, and immunity obviously strengthens, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and some patients self-induction is fully recovered.Take more than 30 days in experimental group, effective percentage can reach 95%, and matched group is only 75%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (1)
1. improve the Chinese medicine composition of tumor patient Postoperative Immunity function, it is characterized in that, take off the crude drug stating weight proportion: Radix Codonopsis 12 parts, Radix Cyathulae 7 parts, Fructus Ligustri Lucidi 9 parts, Poria cum Radix Pini 7 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Puerariae 28 parts, Herba Artemisiae Anomalae 10 parts, Rhizoma Chuanxiong 11 parts, 9 parts, Poria, Herba Centellae 4 parts, salt Fructus Psoraleae (processed) 5 parts, Fructus Toosendan 6 parts, Pollen Pini 7 parts; Preparation method:
(1) Pollen Pini is pulverized, cross 120 mesh sieves;
(2) Radix Codonopsis, Radix Cyathulae, Fructus Ligustri Lucidi, Poria cum Radix Pini, Thallus Laminariae (Thallus Eckloniae), Radix Puerariae, Herba Artemisiae Anomalae, Rhizoma Chuanxiong, Poria, Herba Centellae, salt Fructus Psoraleae (processed) and Fructus Toosendan are placed in marmite, decoct with water 3 times, water consumption is 3 times of crude drug gross weight, 2 hours first times, three gained filtrates, are merged 0.8 hour third time by second time 0.8 hour, leave standstill, filter;
(3) Pollen Pini after step (1) being pulverized adds step (2) gained medicinal liquid, sterile packaged.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510209505.3A CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
| CN201510209545.8A CN104815008A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine powder for improving postoperative immune functions of tumor patients |
| CN201510209504.9A CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209544.3A CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
| CN201410144866.XA CN103908495B (en) | 2014-04-12 | 2014-04-12 | Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function |
| CN201510209341.4A CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
Applications Claiming Priority (1)
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|---|---|---|---|
| CN201410144866.XA CN103908495B (en) | 2014-04-12 | 2014-04-12 | Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510209341.4A Division CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
| CN201510209544.3A Division CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
| CN201510209504.9A Division CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209505.3A Division CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
| CN201510209545.8A Division CN104815008A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine powder for improving postoperative immune functions of tumor patients |
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| Publication Number | Publication Date |
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| CN103908495A CN103908495A (en) | 2014-07-09 |
| CN103908495B true CN103908495B (en) | 2015-09-30 |
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| CN201510209545.8A Withdrawn CN104815008A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine powder for improving postoperative immune functions of tumor patients |
| CN201510209504.9A Withdrawn CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209505.3A Withdrawn CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
| CN201510209544.3A Withdrawn CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
| CN201510209341.4A Withdrawn CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
| CN201410144866.XA Expired - Fee Related CN103908495B (en) | 2014-04-12 | 2014-04-12 | Improve Chinese medicine composition and the method for making of tumor patient Postoperative Immunity function |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510209545.8A Withdrawn CN104815008A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine powder for improving postoperative immune functions of tumor patients |
| CN201510209504.9A Withdrawn CN104784259A (en) | 2014-04-12 | 2014-04-12 | Capsules for improving postoperative immunologic function of tumor patient |
| CN201510209505.3A Withdrawn CN104784260A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine tablets for improving postoperative immunologic function of tumor patient and preparation method |
| CN201510209544.3A Withdrawn CN104771449A (en) | 2014-04-12 | 2014-04-12 | Traditional Chinese medicine ointment capable of improving post-operation immunity of cancer patient |
| CN201510209341.4A Withdrawn CN104771448A (en) | 2014-04-12 | 2014-04-12 | Method for preparing traditional Chinese medicine drug granule improving postoperative immune function of tumor patient |
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| CN104489516A (en) * | 2014-12-03 | 2015-04-08 | 姜秀清 | Health-preserving porridge capable of improving postoperative immune function of cancer paint and preparation method for health-preserving porridge |
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| CN1840036A (en) * | 2005-03-29 | 2006-10-04 | 上海围城自由基生物工程研究所 | Chinese medicinal composite preparation capable of inhibiting growth of tumor cell |
| CN102861236B (en) * | 2012-09-24 | 2015-01-07 | 天津鑫瑞生物医药科技有限公司 | Anti-tumor preparation made of pure traditional Chinese medicines |
| CN103127485A (en) * | 2013-03-07 | 2013-06-05 | 孙文娟 | Medicine for treating tumors |
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- 2014-04-12 CN CN201510209504.9A patent/CN104784259A/en not_active Withdrawn
- 2014-04-12 CN CN201510209505.3A patent/CN104784260A/en not_active Withdrawn
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- 2014-04-12 CN CN201510209341.4A patent/CN104771448A/en not_active Withdrawn
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Also Published As
| Publication number | Publication date |
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| CN104771449A (en) | 2015-07-15 |
| CN104784260A (en) | 2015-07-22 |
| CN104815008A (en) | 2015-08-05 |
| CN103908495A (en) | 2014-07-09 |
| CN104784259A (en) | 2015-07-22 |
| CN104771448A (en) | 2015-07-15 |
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