CN114652785A - Application for primary cold-dampness stagnation type dysmenorrhea and preparation method thereof - Google Patents

Application for primary cold-dampness stagnation type dysmenorrhea and preparation method thereof Download PDF

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CN114652785A
CN114652785A CN202210399926.7A CN202210399926A CN114652785A CN 114652785 A CN114652785 A CN 114652785A CN 202210399926 A CN202210399926 A CN 202210399926A CN 114652785 A CN114652785 A CN 114652785A
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parts
fried
patch
cold
production method
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郑文兰
文晓敏
张鑫
黄李梅
龙金桃
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First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
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First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention relates to a plaster for primary cold-damp stagnation type dysmenorrhea and a preparation method thereof, the formula consists of white atractylodes rhizome fried with bran, fried Chinese yam, morinda officinalis, crushed ginkgo, lotus seed, Chinese angelica, Szechuan lovage rhizome, dried orange peel, white poria, nutgrass galingale rhizome, cassia twig and fried hyacinth bean, and the plaster is prepared by crushing the materials into fine powder by an ultrafine pulverizer, wherein the total effective rate of the plaster for treating the dysmenorrhea is up to 93 percent, and the plaster has a remarkable treatment effect on the primary cold-damp stagnation type dysmenorrhea.

Description

Application for primary cold-dampness stagnation type dysmenorrhea and preparation method thereof
Technical Field
The invention relates to the field of medicine invention, in particular to a patch for primary cold-dampness stagnation type dysmenorrhea and a preparation method thereof.
Background
Dysmenorrhea is one of the most common gynecological symptoms, and refers to those with lower abdominal pain, sagging and distension before and after menstruation or during menstruation, accompanied by soreness of waist or other discomforts, and the symptoms seriously affect the quality of life. Dysmenorrhea is divided into primary dysmenorrhea and secondary dysmenorrhea, wherein primary dysmenorrhea refers to dysmenorrhea caused by genital organ anergy lesion, and accounts for more than 90% of dysmenorrhea. The cold-damp stagnation type is one of the main types of dysmenorrhea, and is mostly caused by invasion of cold and moisture, the cold and the damp are often accumulated in the environment of daily life and work, or the cold and the moisture are suddenly cooled and suddenly heated, so that the cold and the moisture can not be smoothly discharged to form the symptom of blood stasis, the lower jiao is injured by cold and dampness, the blood is congealed by the cold and the blood is not smooth, and the pain is caused, and the menstrual blood is dark and blocky; obstruction of cold-dampness in the middle energizer, obstruction of yang-qi, failure of water-dampness, aversion to cold, loose stool, nausea and vomiting.
At present, western medicines mainly take treatments of analgesia, sedation, spasmolysis, contraception and the like, need to be taken for a long time, have large side effect, are easy to generate tolerance, treat the symptoms and root causes but not treat the symptoms, are easy to repeat, and lack medicines specially aiming at cold-damp stagnation type dysmenorrhea. The traditional Chinese medicine is more and more accepted by people because of the advantages of emphasizing holism, coordinating yin and yang, treating both principal and secondary aspect of disease, having small toxic and side effect and the like.
The existing Chinese patent medicines for treating the dysmenorrhea of women are more, but are mainly oral preparations, although the short-time relieving and the treatment effect are better, the oral preparations need to be taken orally, the first pass effect on the liver and the stimulation on the gastrointestinal tract are also aggravated, the burden on the liver and the kidney of a patient is also increased, and the duration of the action of the medicines is short. Compared with oral administration, the external patch has the advantages of convenient use, small side effect and the like, and is popular with patients with dysmenorrhea. However, the existing external patch for treating dysmenorrhea has the defects of not ideal effect, slow response, complex preparation method and uncertain treatment effect on primary cold-dampness stagnation type dysmenorrhea.
In order to solve the problems, the invention group bases on the holistic concept and dialectical treatment of the traditional Chinese medicine according to the characteristics of the basic theory of the traditional Chinese medicine, takes cold-damp stagnation type dysmenorrhea as a research object, does not contain five traditional Chinese medicines of rhizoma cyperi, ligusticum wallichii, angelica sinensis, cassia twig and dried orange peel in the clinical application at first, finds that the curative effect can be seen from the beginning of the treatment from the angle of warming channels, dispelling cold and relieving pain in the treatment process of cold-damp stagnation type primary dysmenorrhea patients, but the curative effect is not maintained for a long time. According to the traditional Chinese medicine pathogenesis of the primary dysmenorrhea with congealing cold-dampness stagnation, the primary dysmenorrhea is caused by obstruction and pain caused by the invasion of exogenous pathogenic factors, and the later clinical treatment discovers that the primary dysmenorrhea is caused by cold dampness, not only needs to treat the cold but also needs to promote the dampness, dissolves the stasis, takes qi to move blood and takes qi to move blood, and takes qi to move dampness, so that the application of the patch is added with the medicines for promoting the circulation of qi and activating blood, strengthening spleen and clearing damp, and a large amount of clinical exploration proves that the five traditional Chinese medicines of rhizoma cyperi, ligusticum wallichii, angelica sinensis, cassia twig and dried orange peel can obviously improve the curative effect and have good persistence, so that the patch special for treating the primary dysmenorrhea with congealing cold-dampness stagnation is prepared by bran-fried bighead atractylodes rhizome, fried Chinese yam, morinda root meat, crushed ginkgo, lotus seed (without removing the heart), angelica sinensis, ligusticum wallichii, dried orange peel, white poria cocos, rhizoma cyperi, cassia twig and fried hyacinth beans, the preparation method is simple, and has obvious curative effect on treating the primary dysmenorrhea with congealing cold-dampness and congealing stagnation, is safe and convenient and has small side effect.
Disclosure of Invention
The invention aims to provide a patch for primary cold-damp stagnation type dysmenorrhea.
The invention also aims to provide a preparation method of the primary cold-damp stagnation type dysmenorrhea patch.
The formula of the plaster provided by the invention is as follows: 20-40 parts of bran-fried bighead atractylodes rhizome, 10-20 parts of fried Chinese yam, 10-20 parts of morinda officinalis, 10-20 parts of smashed ginkgo, 10-20 parts of lotus seed, 10-20 parts of angelica, 10-20 parts of ligusticum wallichii, 10-20 parts of dried orange peel, 5-15 parts of white poria, 5-15 parts of rhizoma cyperi, 5-15 parts of cassia twig and 5-15 parts of fried hyacinth bean.
Preferably, the first and second liquid crystal materials are,
the formula of the plaster provided by the invention is as follows: 25-35 parts of bran-fried bighead atractylodes rhizome, 12-18 parts of fried Chinese yam, 12-18 parts of morinda officinalis, 12-18 parts of smashed ginkgo, 12-18 parts of lotus seed, 12-18 parts of angelica, 12-18 parts of ligusticum wallichii, 12-18 parts of dried orange peel, 8-12 parts of white poria, 8-12 parts of rhizoma cyperi, 8-12 parts of cassia twig and 8-12 parts of fried hyacinth bean.
It is further preferred that the first and second liquid crystal compositions,
the formula of the plaster provided by the invention is as follows: 30 parts of bran-fried bighead atractylodes rhizome, 15 parts of fried Chinese yam, 15 parts of morinda officinalis, 15 parts of smashed ginkgo seed, 15 parts of Jian lotus seed, 15 parts of Chinese angelica, 15 parts of ligusticum wallichii, 15 parts of dried orange peel, 10 parts of white poria, 10 parts of rhizoma cyperi, 10 parts of cassia twig and 10 parts of fried hyacinth bean.
The preparation method of the plaster comprises the following steps: (1) taking the traditional Chinese medicines according to the formula amount, respectively crushing the traditional Chinese medicines into fine powder which is sieved by a 380-plus-420-mesh sieve by using a traditional Chinese medicine ultrafine crusher, uniformly mixing the fine powder, and then sterilizing the mixture for 35 to 45min at the sterilization pressure of 95 to 105kPa and the temperature of 110-plus-120 ℃ for later use; (2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 7-10cm and thickness of 2-4 mm; (3) placing 15-25g of the medicinal cake on a gas-permeable adhesive plaster, and preparing a patch with proper size according to the position of the acupuncture point.
Preferably, the first and second liquid crystal materials are,
the application preparation method comprises the following steps (1): pulverizing the Chinese medicinal materials into fine powder of 400 mesh by a Chinese medicinal micronizer, mixing, and sterilizing at 116 deg.C under 101kPa for 40 min.
Preferably, the first and second liquid crystal materials are,
the application preparation method comprises the following steps (2): mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 8-9cm and thickness of 2.5-3.5 mm.
It is further preferred that the first and second liquid crystal compositions,
the application preparation method comprises the following steps (2): mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 8cm and thickness of 3 mm.
Preferably, the first and second liquid crystal materials are,
the application preparation method comprises the following steps (3): placing 20g of the medicinal cake on a breathable adhesive plaster, and preparing a patch with a proper size according to the position of the acupuncture point.
It is further preferred that the first and second liquid crystal compositions,
the application preparation method of the invention comprises the steps of 3), the acupuncture points are qi sea, guanyuan and Zhongji of the lower abdomen; mingmen, Yaoyangguan and Xialiao in the lumbosacral region.
The application of the patch provided by the invention in preparation of medicines for treating primary cold-damp stagnation type dysmenorrhea is disclosed.
The traditional Chinese medicine lotus seed is the lotus seed without removing the core.
The parts by weight referred to in the present invention may be units conventional in the art, and may be g, kg, etc.
Advantageous effects
1. The formula of the application is based on the characteristics of the basic theory of the traditional Chinese medicine, the holistic concept and dialectical treatment of the traditional Chinese medicine are taken as the basis, the pathogenic mechanism analysis of the primary cold-dampness stagnation type dysmenorrhea is taken as the research object, the five traditional Chinese medicines of rhizoma cyperi, ligusticum wallichii, angelica sinensis, cassia twig and dried orange peel are not used in the clinical application at first, the curative effect can be seen from the aspect of 'warming channels, dispelling cold and relieving pain' in the treatment process of the primary dysmenorrhea with the cold-dampness stagnation type, but the maintenance time of the curative effect is short. According to the traditional Chinese medicine pathogenesis of dysmenorrheal cold-dampness stagnation syndrome in the traditional Chinese medicine, the main reason of dysmenorrheal is that dysmenorrheal is caused by careless breathing and cold-dampness is confined in cells, and dysmenorrheal is caused, the cold is treated in later-stage clinical treatment, the dampness is better to be removed, stasis is dissolved, qi is taken to be moved to be blood, and qi is moved to be damp, so that the medicine for promoting qi and activating blood circulation, tonifying spleen and clearing damp is added in the application of the formula, and the five traditional Chinese medicines of nutgrass galingale rhizome, szechuan lovage rhizome, Chinese angelica, cassia twig and dried orange peel are added after clinical exploration, so that the curative effect is obviously improved, and the risk of relapse and aggravation of dysmenorrheal is reduced, therefore, the formula is finally determined to be composed of bran-fried bighead atractylodes rhizome, fried lotus seed, morinda officinalis, ginkgo seed, medicinal herbs for building (without removing heart), Chinese angelica, szechuan lovage rhizome, dried orange peel, white poria cocos, nutgrass galingale rhizome, cassia twig and stir-fried hyacinth bean.
2. The prescription of the invention is explained by the definition, wherein the bighead atractylodes rhizome is the monarch drug in the prescription, dampness is eliminated to benefit qi of navel and waist, and the tuckahoe and the dried orange peel are used together to promote spleen qi to eliminate dampness, so that the effect of the bighead atractylodes rhizome is enhanced and dampness can be prevented from being dissipated into heat for a long time; morinda officinalis, radix Morindae officinalis, rhizoma Dioscoreae, semen lablab album, and semen Nelumbinis can warm kidney yang to relieve cold pain in lower abdomen, and ramulus Cinnamomi can warm channels and promote spleen yang to eliminate cold dampness(not to remove the heart)The spleen invigorating, qi benefiting, dampness removing, constitution strengthening and pulse protecting medicine is ministerialThe medicine and the ginkgo seed are used as assistant medicines to serve as a channel-guiding medicine, the morinda officinalis is sweet and warm to enter the conception vessel, the rhizoma cyperi is used as a medicine for warming cold and dampness in blood and regulating qi to alleviate pain, the qi is used for promoting blood circulation, and the ligusticum wallichii and the angelica sinensis are used as assistant medicines for promoting blood circulation, removing blood stasis and relieving pain, so that the basic theory and the dialectical treatment of the traditional Chinese medicine are met.
3. The points selected by the invention are the lower abdomen and the lumbosacral part with serious primary menstrual pain according to the applied positions. Qi sea, Guanyuan and Zhongji are all acupoints on the ren channel, and qi sea generates qi and primordial qi, so qi sea is got to supplement qi and strengthen yang. Guanyuan and Zhongji are the intersections of liver meridian of foot jueyin, spleen meridian of foot taiyin, kidney meridian of foot shaoyin and ren meridian, so it can tonify spleen, sooth liver, warm kidney, strengthen yang, regulate Chong and ren meridians and warm uterus. The application area of the lumbosacral part is mainly the acupoint on the governor vessel and the bladder meridian of foot taiyang, the governor vessel is the sea of the yang pulse, the bladder meridian governs the exterior yang of the body, the acupoint on the meridian is selected to stimulate the yang qi of the human body, to exert the effects of warming yang and dispelling cold, to strengthen the wei-defensive yang and prevent the invasion of cold-damp evil, and the Mingmen, the waist yang guan and the Xialiao on the two meridians to exert the effects of warming kidney, tonifying yang, dispelling cold and dredging stagnation. Therefore, the effects of warming and invigorating can be cooperatively exerted, so that yang qi is vigorous, blood and vessel are ventilated, cold and dampness is removed, and the curative effects are mutually complemented.
4. The basic situation of the invention refers to the 8 th edition of teaching material "gynaecology and obstetrics", the standard of traditional Chinese medicine syndrome differentiation: according to the 3 rd edition of teaching materials of traditional Chinese medicine gynecology and the clinical research guide principle of new traditional Chinese medicines, 58 cases are randomly divided into an observation group and a control group, 29 cases are respectively taken in each group, the age is 15-28 years, the course of disease is 2-7 years, and the difference of the general data of two groups of patients has no statistical significance and has comparability.
5. The treatment standard of the invention refers to the 'curative effect standard of traditional Chinese medicine symptoms' (the national traditional Chinese medicine administration, the standard of curative effect for diagnosing traditional Chinese medicine symptoms and signs [ S ]. Nanjing: Nanjing university publisher, 1994:61.), and the result shows that the total effective rate of the traditional Chinese medicine application for treating the dysmenorrhea is up to 93 percent and is obviously higher than that of a control group, which indicates that the effect of treating the primary dysmenorrhea by local percutaneous absorption is obvious.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1 formulation
30g of bran-fried bighead atractylodes rhizome, 15g of fried Chinese yam, 15g of morinda officinalis, 15g of smashed ginkgo, 15g of jianlian, 15g of angelica, 15g of ligusticum wallichii, 15g of dried orange peel, 10g of white poria, 10g of rhizoma cyperi, 10g of cassia twig and 10g of fried hyacinth bean.
Example 2 formulation
20g of bran-fried bighead atractylodes rhizome, 10g of fried Chinese yam, 10g of morinda officinalis, 10g of smashed ginkgo, 10g of jianlian lotus seed, 10g of angelica, 10g of ligusticum wallichii, 10g of dried orange peel, 5g of white poria, 5g of rhizoma cyperi, 5g of cassia twig and 5g of fried hyacinth bean.
Example 3 formulation
40g of bran-fried bighead atractylodes rhizome, 20g of fried Chinese yam, 20g of morinda officinalis, 20g of smashed ginkgo, 20g of jianlian, 20g of angelica, 20g of ligusticum wallichii, 20g of dried orange peel, 15g of white poria, 15g of rhizoma cyperi, 15g of cassia twig and 15g of fried hyacinth bean.
Example 4 formulation
25g of bran-fried bighead atractylodes rhizome, 12g of fried Chinese yam, 12g of morinda officinalis, 12g of smashed ginkgo, 12g of jianlian lotus seed, 12g of Chinese angelica, 12g of szechuan lovage rhizome, 12g of tangerine peel, 8g of white poria, 8g of nutgrass galingale rhizome, 8g of cassia twig and 8g of fried hyacinth bean.
Example 5 formulation
35g of bran-fried bighead atractylodes rhizome, 18g of fried Chinese yam, 18g of morinda officinalis, 18g of smashed ginkgo seed, 18g of jian lotus seed, 18g of angelica, 18g of ligusticum wallichii, 18g of dried orange peel, 12g of white poria, 12g of rhizoma cyperi, 12g of cassia twig and 12g of fried hyacinth bean.
The formulations of examples 1-5 were prepared according to the methods of any of the following examples.
EXAMPLE 6 preparation method
(1) Pulverizing the Chinese medicinal materials into fine powder of 400 mesh by a Chinese medicinal micronizer, mixing, and sterilizing at 116 deg.C under 101kPa for 40 min;
(2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 8cm and thickness of 3 mm;
(3) placing 20g of the medicinal cake on a breathable adhesive tape, and placing the medicinal cake on the abdomen: Qihai-Zhongji 8cm, inner diameter of the medicine cake is designed to be 8 x 4cm, waist: the distance between Mingmen and Xialiao is 9cm, the distance between Xialiao and Xialiao is 4cm, and the inner diameter of the medicated cake is 9 × 4 cm.
Example 7 preparation method
(1) Respectively pulverizing the traditional Chinese medicines into fine powder passing through a 380-mesh sieve by using a traditional Chinese medicine ultrafine pulverizer, uniformly mixing, and sterilizing at the sterilization pressure of 101kPa and the temperature of 116 ℃ for 40min for later use;
(2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 7cm and thickness of 2 mm;
(3) taking 15g of the medicine cake, placing on a breathable adhesive tape, and placing on the abdomen: Qihai-Zhongji 7cm, inner diameter of the medicine cake is designed to be 7 x 2cm, waist: the distance between Mingmen and Xialiao is 7cm, the distance between Xialiao and Xialiao is 2cm, and the inner diameter of the medicated cake is 7 × 2 cm.
EXAMPLE 8 preparation method
(1) Pulverizing the Chinese medicinal materials into fine powder of 420 mesh by a Chinese medicinal micronizer, mixing, and sterilizing at 110 deg.C under 95kPa for 35 min;
(2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 10cm and thickness of 4 mm;
(3) taking 25g of the medicine cake, placing on a breathable adhesive tape, and placing on the abdomen: Qihai-Zhongji 10cm, inner diameter of the medicine cake is 10 x 4cm, waist: the distance between Mingmen and Xialiao is 10cm, the distance between Xialiao and Xialiao is 4cm, and the inner diameter of the medicated cake is 10 × 4 cm.
Example 9 preparation method
(1) Pulverizing the Chinese medicinal materials into fine powder of 400 mesh by a Chinese medicinal micronizer, mixing, and sterilizing at 105kPa and 120 deg.C for 45 min;
(2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 9cm and thickness of 3 mm;
(3) placing 18g of the medicinal cake on a breathable adhesive tape, and placing the medicinal cake on the abdomen: Qihai-Zhongji 9cm, inner diameter of the medicine cake is designed to be 8 x 3cm, waist: the distance between Mingmen and Xialiao is 8cm, the distance between Xialiao and Xialiao is 3cm, and the inner diameter of the medicated cake is 8 × 3 cm.
EXAMPLE 10 preparation method
(1) Pulverizing the Chinese medicinal materials into fine powder of 400 mesh by a Chinese medicinal micronizer, mixing, and sterilizing at 98kPa and 115 deg.C for 38 min;
(2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 10cm and thickness of 2 mm;
(3) placing 20g of the medicinal cake on a breathable adhesive tape, and placing the medicinal cake on the abdomen: Qihai-Zhongji 10cm, inner diameter of the medicine cake is designed to be 8 x 2cm, waist: the distance between Mingmen and Xialiao is 8cm, the distance between Xialiao and Xialiao is 4cm, and the inner diameter of the medicated cake is 10 × 2 cm.
To further verify the effectiveness of the present invention, the inventors performed a series of verification tests, specifically as follows:
1. application formulation screening
The study takes cold-dampness stagnation type dysmenorrhea as a study object, the formula does not contain five traditional Chinese medicines of rhizoma cyperi, ligusticum wallichii, angelica sinensis, cassia twig and dried orange peel in clinical application at first, and in the treatment process of primary dysmenorrhea patients with cold-dampness stagnation type, the treatment effect can be seen from the aspect of warming channels, dispelling cold and relieving pain at the beginning, but the persistence is not good. According to the traditional Chinese medicine pathogenesis of dysmenorrheal cold-dampness stagnation syndrome in the traditional Chinese medicine, the main reason is that the dysmenorrheal is caused by careless nature of the body, cold-dampness is confined in cells, obstruction leads to pain, and the dysmenorrheal is discovered in later-stage clinical treatment, the cold-dampness is treated, the dampness is removed, the stasis is dissolved, and the idea that' qi circulation leads to blood circulation and qi circulation leads to dampness is taken, so that the medicine for promoting qi circulation and activating blood circulation and tonifying spleen and clearing damp is added in the application of the formula, and the five traditional Chinese medicines of rhizoma cyperi, ligusticum wallichii, angelica sinensis, cassia twig and dried orange peel are added after clinical exploration, so that the curative effect is obviously increased, and the risk of relapse and aggravation of the dysmenorrheal is reduced, and the formula is finally determined to be composed of bran-fried bighead atractylodes rhizome, fried Chinese yam, morinda officinalis, ginkgo, medicinal materials for building up without mashing, angelica sinensis, ligusticum wallichii, dried orange peel, white poria cocos, rhizoma cyperi, cassia twig and fried hyacinth beans.
2. Explanation of prescription of application
In the formula, the largehead atractylodes rhizome is the monarch drug, dampness is eliminated to benefit qi of the navel and the waist, and the tuckahoe and the tangerine peel are used together to strengthen the efficacy of the largehead atractylodes rhizome and prevent dampness from transforming into heat for a long time; morinda officinalis warms up kidney yang and relieves cold pain in lower abdomen, cassia twig warms up channel and helps spleen yang to eliminate cold dampness, Chinese yam, white hyacinth bean and lotus seed (without removing heart) are used as ministerial drugs for invigorating spleen, tonifying qi, promoting diuresis, strengthening and protecting thoroughfare and conception vessel, ginkgo seed is used as an assistant and guide drug for leading channels, Morinda officinalis is used for enabling sweet taste and warm in conception vessel, warming and resolving cold dampness, Cyperus rotundus is used for regulating qi in blood, regulating qi to relieve pain, and qi circulation is used for promoting blood circulation, and Ligusticum wallichii and Chinese angelica are used as assistant drugs for promoting blood circulation, removing blood stasis and relieving pain.
3. Application recipe confirmation
Combining the screening of the application formula and the explanation of the prescription, the dosage and the efficacy of each Chinese medicament are determined as follows: 30g of bran-fried bighead atractylodes rhizome, 15g of fried Chinese yam, 15g of morinda officinalis, 15g of smashed ginkgo, 15g of jianlian (without removing the core), 15g of angelica, 15g of ligusticum wallichii, 15g of dried orange peel, 10g of poria alba, 10g of rhizoma cyperi, 10g of cassia twig and 10g of fried hyacinth bean.
4. Confirmation of application preparation method
4.1 Point selection
Qihai, guanyuan, Zhongji, Mingmen, Yaoyangguan, and Xialiao; gas sea: on the midline of the abdomen, 1.5 cun below the umbilicus, guanyuan: on the anterior midline, 3 cun below the umbilicus: 4 cun below the umbilicus on the anterior midline, Mingmen: in the inferior depression of the spinous process of lumbar vertebra, on the posterior midline, in the lumbar region: in the inferior depression of the spinous process of lumbar vertebra 4, on the posterior midline, xialiao: opposite the posterior sacral foramen 2 in the sacral region.
4.2 the basis of selection of acupoints
The application sites are the lower abdomen and lumbosacral region with severe primary menstrual pain. Qi sea, Guanyuan and Zhongji are all acupoints on the ren channel, and qi sea generates qi and primordial qi, so qi sea is got to supplement qi and strengthen yang. Guanyuan and Zhongji are the intersections of liver meridian of foot jueyin, spleen meridian of foot taiyin, kidney meridian of foot shaoyin and ren meridian, so it can tonify spleen, sooth liver, warm kidney, strengthen yang, regulate Chong and ren meridians and warm uterus. The application area of the lumbosacral part is mainly the acupoint on the governor vessel and the bladder meridian of foot taiyang, the governor vessel is the sea of the yang pulse, the bladder meridian governs the exterior yang of the body, the acupoint on the meridian is selected to stimulate the yang qi of the human body, exert the efficacy of warming yang and dispelling cold, strengthen the wei-yang and prevent the invasion of cold-damp evil qi, and the Mingmen, the waist yang guan and the Xialiao on the two meridians exert the efficacy of warming kidney, tonifying yang, dispelling cold and dredging stagnation. Therefore, the effects of warming and invigorating can be cooperatively exerted, so that yang qi is vigorous, blood and vessel are ventilated, cold and dampness is removed, and the curative effects are mutually complemented.
4.3 application size design
Abdomen: qihai-medium pole about 8cm, inner diameter of the medicine cake is designed to be 8 x 4cm, waist: the distance between Mingmen and Xialiao is 9cm, the distance between Xialiao and Xialiao is about 4cm, and the inner diameter of the cake is 9 × 4 cm.
4.4 preparation method of application
Grinding into fine powder with a Chinese medicinal ultrafine pulverizer, sieving with 400 mesh sieve, sterilizing at 116 deg.C under 101kPa for 40min, sealing, storing in a sealed bottle, storing in dark place, adding appropriate amount of yellow wine and Mel, concocting into paste, making into pill, and pressing into oval medicinal cake with diameter of 8-9cm and thickness of 3 mm. Placing the obtained medicinal cake on gas-permeable adhesive plaster.
5. Case analysis
5.1 case criteria
Western medicine standard: referring to the 8 th edition of teaching materials, gynecology and obstetrics, the standard of traditional Chinese medicine syndrome differentiation: according to the 3 rd edition of teaching materials of 'traditional Chinese medicine gynecology' and 'clinical research guiding principle of new traditional Chinese medicines', 58 cases are randomly divided into an observation group and a control group, 29 cases are respectively taken in each group, the age is 15-28 years, the course of disease is 2-7 years, and compared with general data of two groups of patients, the difference has no statistical significance and is comparable.
5.2 criteria for treatment
Reference is made to "therapeutic standard for disease of traditional Chinese medicine" (national administration of traditional Chinese medicine, standard for therapeutic treatment for diagnosis of disease of traditional Chinese medicine [ S ]. Nanjing: Nanjing university Press, 1994: 61.).
5.3 application operation
The prepared medicated cake is placed on air-permeable adhesive plaster, and applied to the above acupuncture points 7 days before menstruation, 1 time per day, 4-6 hours per time, and 7 times for 1 treatment course (two applications at one time, 14 applications in 1 treatment course, and ordering the patient to put a hot water bag on the application, and heat for 1 hour to aid the efficacy of medicine).
5.4 methods of treatment
5.4.1 treatment groups
The plaster is prepared by coating 20g of the ointment containing the medicine on a designed plaster, wherein the acupuncture points of the abdomen and the lumbosacral part are selected from the acupuncture points of the abdomen and the lumbosacral part, the plaster is applied 7 days before menstruation, 1 time is taken every day, each time is 4-6 hours, the application time is 7 times, 1 treatment course is used continuously for 7 days, the plaster is repeatedly used 7 days before the next menstruation, and the 3-month menstruation period is continuously treated.
5.4.2 control group
The tablets (made by Shaanxi Dongtai pharmaceutical Co., Ltd., national Standard Z20050410) for relieving pain are administered orally 3 tablets/time (0.6 g/tablet) for 3 times/day. The medicine is taken 7 days before menstruation, and is stopped for 7 days continuously, and is taken 7 days before next menstruation. Treatment was continued for a 3 month period.
5.4.3 treatment results statistics of clinical observations after 3 months of continuous treatment are shown in Table 1.
Table 1 comparative examples of therapeutic effects of two methods (%)
Figure BDA0003599407000000071
As can be seen from Table 1, the total effective rate of treating dysmenorrhea by applying the traditional Chinese medicine is as high as 93%, which is significantly higher than that of the control group, and the result shows that the effect of treating primary dysmenorrhea by local percutaneous absorption is significant.
5.5 typical cases
Case 1
Patient li, woman, age 27, address: guizhou province Guiyang city Huaxi district
In 5+ year, abdominal pain during menstruation appears after raining in menstrual period, which is 1-2 days later, accompanied by scanty menstrual flow, dark purple color, blood clots and cold limbs. After the patch is used for 3 months, the abdominal pain of a patient during menstruation is basically improved, and the menstruation amount is increased compared with the former menstruation amount. Supplementary survey (2020.11.19) E2: 34.72pg/ml, P:1.01nmol/l, (2021.01.20) E2: 21.79pg/ml, P2.56 nmol/l.
Case 2
Patient dudi, woman, age 28, address: chenjin county, Bijie city, Guizhou province
The patient prefers to eat cold drink because of Pingxing, the abdominal pain during menstruation appears 6+ years ago, even 1-2 days in the menstrual period, the menstrual volume is normal, the color is purple dark, a little blood clot is included, the waist is sore, and the sleep is affected when the abdominal pain occurs. After the patch is used for 3 months, the abdominal pain of a patient during menstruation is obviously improved, and menstrual blood basically has no blood clot. Supplementary survey (2021.02.26) E2: 41.73pg/ml, P:0.56nmol/l, (2021.05.28) E2: 23.45pg/ml, P3.55 nmol/l.
Case 3
Patient liu, woman, 24 years old, address: south Ming district of Guizhou Guiyang City
The patient feels cold and likes eating cold drink, the abdominal pain during menstruation appears 4+ years ago, the menstrual period is 1 day, the menstrual volume is normal, the color is purple dark, blood clots do not exist, the waist is sore, and the patient is restless in sitting and lying during the attack. After the patch is used for 3 months, the abdominal pain of a patient during menstruation is obviously improved. Supplementary survey (2021.02.07) E2: 37.06pg/ml, P:1.23nmol/l,
(2021.04.12)E2：22.72pg/ml，P:3.48nmol/l。
case 4
Patient old, female, 24 years old, address: south Ming district of Guizhou Guiyang City
The patient suffers from abdominal pain during menstruation after feeling cold in 6+ year, the pain is more than 2 days, the menstrual blood volume is normal, the color is purple dark, a large number of blood clots exist, the patient is intolerant of cold, and the work and the study are influenced during the attack. After using the patch for 3 months, the abdominal pain of the patient completely disappears during menstruation. Supplementary survey (2021.03.15) E2: 27.80pg/ml, P:4.49nmol/l, (2021.05.12) E2: 24.57pg/ml, P3.48 nmol/l.
Case 5
Patient is Yuan-Chi, female, age 26, address: south Ming district of Guizhou Guiyang City
The patient is happy to eat raw or cold food, abdominal pain appears in menstruation 5+ years ago, the pain is 1-2 days, the menstrual flow is normal, the color is purple dark, blood clots exist, the patient is feared of cold, cold sweat is dribbling, and the patient needs to take the analgesic orally when the pain occurs. After the patch is used for 3 months, abdominal pain of a patient basically disappears during menstruation. Supplementary survey (2021.01.28) E2: 46.28pg/ml, P:1.82nmol/l,
(2021.03.26)E2：27.95pg/ml，P:3.51nmol/l。
case 6
Patient zhangzhi, woman, age 21, address: the province of Guizhou province, Bijie city
The patient is happy to eat raw or cold food, the menstrual abdominal pain appears 4+ years ago, the pain is more than 2 days, the menstrual flow is less, the color is purple and dark, the blood clot exists, the complexion is pale, and the waist is sore and painful. After using the patch for 3 months, abdominal pain of the patient disappears during menstruation. Supplementary survey (2020.07.13) E2: 24.28pg/ml, P:0.99nmol/l, (2020.10.16) E2: 20.56pg/ml, P:2.98 nmol/l.
Case 7
Patient poppy, female, age 22, address: guizhou province Anshun college
The patient prefers to eat raw or cold food, has abdominal pain during menstruation 3+ years ago, pain for 1-2 days, normal menstrual flow, dark purple color, little blood clot, intolerance of cold and soreness of waist. After the patch is used for 3 months, the abdominal pain of the patient can be cured after menstruation. Supplementary survey (2020.01.11) E2: 17.05pg/ml, P:1.40nmol/l, (2020.03.13) E2: 23.1pg/ml, P:3.52 nmol/l.
Case 8
Patient li, woman, age 27, address: university of Guizhou province
The patient feels cold and likes eating raw or cold, and has abdominal pain during menstruation, pain for 1-2 days, normal menstrual flow, dark purple color, blood clot and cold limbs 4+ years ago. After the patch is used for 3 months, the abdominal pain of the patient can be cured after menstruation. Supplementary survey (2020.04.04) E2: 16.71pg/ml, P:0.96nmol/l, (2020.07.02) E2: 22.05pg/ml, P:2.96 nmol/l.
Case 9
Patient yellow certain, female, age 17, address: a high school in Qingzhen city of Guizhou province
The patient feels cold and likes to eat raw or cold, has abdominal pain during menstruation 3+ years ago, is painful for 1-2 days, has little menstrual flow, is dark purple, has blood clots, is accompanied by cold limbs, and needs to lie in bed for rest when the patient is attacked. After the patch is used for 3 months, the abdominal pain of the patient is basically cured during menstruation. Supplementary survey (2021.01.29) E2: 25.93pg/ml, P:3.11nmol/l,
(2021.04.02)E2：20.76pg/ml，P:4.12nmol/l。
case 10
Patient, any, woman, age 20, address: guiyang city cloud rock area of Guizhou province
The patient prefers to eat raw or cold food, has abdominal pain during menstruation 2+ years ago, pain for 1-2 days, less menstrual flow, dark purple color, blood clot, cold limbs and pale complexion, and needs to take analgesic orally when the patient attacks. After the patch is used for 3 months, abdominal pain of a patient basically disappears during menstruation. Supplementary survey (2021.02.24) E2: 39.06pg/ml, P:1.21nmol/l, (2021.05.26) E2: 25.55pg/ml, P2.72 nmol/l.
Although the invention has been described in detail in the foregoing by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that various modifications and improvements can be made thereto without departing from the spirit of the invention.

Claims (10)

1. A patch for primary cold-dampness stagnation type dysmenorrhea is characterized in that the patch comprises the following components: 20-40 parts of bran-fried bighead atractylodes rhizome, 10-20 parts of fried Chinese yam, 10-20 parts of morinda officinalis, 10-20 parts of smashed ginkgo, 10-20 parts of lotus seed, 10-20 parts of angelica, 10-20 parts of ligusticum wallichii, 10-20 parts of dried orange peel, 5-15 parts of white poria, 5-15 parts of rhizoma cyperi, 5-15 parts of cassia twig and 5-15 parts of fried hyacinth bean.
2. A patch according to claim 1, wherein said patch is of a composition comprising: 25-35 parts of white atractylodes rhizome stir-fried with bran, 12-18 parts of stir-fried Chinese yam, 12-18 parts of morinda officinalis, 12-18 parts of smashed ginkgo, 12-18 parts of jianlian lotus seed, 12-18 parts of angelica, 12-18 parts of ligusticum wallichii, 12-18 parts of dried orange peel, 8-12 parts of white poria, 8-12 parts of rhizoma cyperi, 8-12 parts of cassia twig and 8-12 parts of stir-fried hyacinth bean.
3. A patch according to claim 2, wherein said patch is of the formula: 30 parts of bran-fried bighead atractylodes rhizome, 15 parts of fried Chinese yam, 15 parts of morinda officinalis, 15 parts of smashed ginkgo, 15 parts of jianlian, 15 parts of angelica, 15 parts of ligusticum wallichii, 15 parts of dried orange peel, 10 parts of white poria, 10 parts of rhizoma cyperi, 10 parts of cassia twig and 10 parts of fried hyacinth bean.
4. A method of producing a patch according to claims 1-3, characterized in that the production method comprises the steps of: (1) taking the traditional Chinese medicines according to the formula amount, respectively crushing the traditional Chinese medicines into fine powder which is sieved by a 380-plus-420-mesh sieve by using a traditional Chinese medicine ultrafine crusher, uniformly mixing the fine powder, and then sterilizing the mixture for 35 to 45min at the sterilization pressure of 95 to 105kPa and the temperature of 110-plus-120 ℃ for later use; (2) mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 7-10cm and thickness of 2-4 mm; (3) placing 15-25g of the medicinal cake on a gas-permeable adhesive plaster, and preparing a patch with proper size according to the position of the acupuncture point.
5. The production method according to claim 4, characterized in that the production method step (1) is: pulverizing the Chinese medicinal materials into fine powder of 400 mesh by a Chinese medicinal micronizer, mixing, and sterilizing at 116 deg.C under 101kPa for 40 min.
6. The production method according to claim 4, characterized in that the production method step (2) is: mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 8-9cm and thickness of 2.5-3.5 mm.
7. The production method according to claim 6, characterized in that the production method step (2) is: mixing the sterilized mixed fine powder with appropriate amount of yellow wine and Mel to obtain paste, making into pill, and pressing into oval medicinal cake with diameter of 8cm and thickness of 3 mm.
8. The production method according to claim 4, characterized in that the production method step (3) is: placing 20g of the medicinal cake on a breathable adhesive plaster, and preparing a patch with a proper size according to the position of the acupuncture point.
9. A patch according to claim 4, wherein said acupoints of step 3) are qi sea, guanyuan and Zhongji of the lower abdomen; mingmen, Yaoyangguan and Xiliao at the lumbosacral region.
10. A patch according to claims 1-3, for use in the preparation of a medicament for the treatment of primary dysmenorrhea of the cold-damp stagnation type.
CN202210399926.7A 2022-04-15 2022-04-15 Application for primary cold-dampness stagnation type dysmenorrhea and preparation method thereof Pending CN114652785A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106880827A (en) * 2017-04-09 2017-06-23 张鹏 A kind of Chinese medicine composition for treating the sluggish type dysmenorrhoea of cold-dampness
CN108653680A (en) * 2018-07-28 2018-10-16 遵义医学院珠海校区 A kind of navel paster for treating menorrhalgia of cold-stagnation and blood-stasis type

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106880827A (en) * 2017-04-09 2017-06-23 张鹏 A kind of Chinese medicine composition for treating the sluggish type dysmenorrhoea of cold-dampness
CN108653680A (en) * 2018-07-28 2018-10-16 遵义医学院珠海校区 A kind of navel paster for treating menorrhalgia of cold-stagnation and blood-stasis type

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朱坤福: "《中医外治特效疗法》", 31 May 2019 *
龙金桃 等: "加味温脐化湿汤治疗寒湿凝滞型原发性痛经疗效", 《现代中西医结合杂志》 *

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